Gene PFKFB3 in Homo sapiens

Synonym: IPFK2, PFK2, RP11-298K24.3, PFKFB3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP148_AA protein Get Run
HsapP148_AA_253-459 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 41-260 3.3e-110 356.8 Pfam-A 5-223 (223) alignment
Range on Protein: 41-260
Range on HMM: 5-223/223.0
CGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDA
....|.||..|||.|||||||||||||||||||.|.||.|||||||.|||||||..|...|||||||||.|.|...|||||.|...||..|.||.|.|||
tvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDA

TNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDpDKCDRDLSLIKVIDVGRRFLVNR
||||||||..||.|..||..|..|.||||.|......||.|||.|||||||....||..||.||...||..|.||| |..|..||.|||||||....||.
tNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyepld.deedeelsyIkvidvgkslvvnn

VQDHIQSRIVYYLMNIHVQP
||...||||||||.|||..|
vqgylqsrivyyllNihlkp

subfamily_PFKFB_pd Subfamily PFKFB 255-450 3.9e-101 328.5 In-house 1-197 (198) alignment
Range on Protein: 255-450
Range on HMM: 1-197/198.0
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDT
|||..||.|||.|||| |.| .||||||| |..||...|..|.||..|.|||.||||||.|| ||||||.|.||.||||||.|.|||.|..||||||...
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELER-QENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNV
.|||.. |..||| ||||.||||.||||||||||.|||| |||||.|.||||||.||||.|||||||.||||.|||||.|||||||||.||.. |.|
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv

0035570 Phosphoglycerate mutase-like 262-459 9.8e-61 197.1 In-house 1-198 (219) alignment
Range on Protein: 262-459
Range on HMM: 1-198/219.0
TIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYAL
..||.|||| |.||.||. ||..|. ||.. | || ..  .....  .|..| |. .|||||.. ||.|....|.|||.|..| ||..||...||||.|.
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

REQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER
. .|.|.||.| |||..|.|.|..|...|||..|||||..|..|.|.||||.|. ..||...|..| ..|..|.. ..|.... ..||  |. .....
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlellle

0039931 Phosphoglycerate mutase-like 262-451 7.7e-60 194.1 In-house 1-190 (219) alignment
Range on Protein: 262-451
Range on HMM: 1-190/219.0
TIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYAL
..||.|||| |.|..||. |||.|. ||.. | || ..  ...|.  .|..| |. .|||||.. ||.|....|.|||.|..| ||.|||...||||.|.
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

REQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVE
. .|.|.||.| |||..|.|.|..|...||...|||||..|..|.|.||||.|. | ||...|..| ..|..|.. ..|.......|. .
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltsh

0053607 Phosphoglycerate mutase-like 260-445 4.7e-54 175.0 In-house 1-186 (191) alignment
Range on Protein: 260-445
Range on HMM: 1-186/191.0
PRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEY
....||.|||| |.|..||. ||..|. .|.. | || ..  |..||  .|..| |. ..||||.. ||.|....|.|||.|..| ||.||....||||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVES
|.. .|...||.| |||..|...|..|...|| ...||||..|..|.|.||||.|. . ||...|..| ..|..|..  .|.....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvl

0036777 Phosphoglycerate mutase-like 260-452 1.3e-52 171.1 In-house 2-233 (247) alignment
Range on Protein: 260-452
Range on HMM: 2-233/247.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  |..|. .|.. | || ... |..|.  .|..| |. .|||||..        ||......|.|.| |..| ||..|
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

IRDTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEE
|...||||.... .|.|.||.                         | |||..|.|.|..|...|| ..     |||||..|..|||.||||.|. | |.
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

MPYLKCPLHTVLKLTPVAYGCRVESIYLNVES
...|..| .....|.  ..| ..  ..||  |
ilrlnlpngsitvleldddgklwvleslndts

0037864 Phosphoglycerate mutase-like 254-446 6.2e-52 168.3 In-house 1-207 (211) alignment
Range on Protein: 254-446
Range on HMM: 1-207/211.0
MNIHVQPRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCE
|.........||.|||| |.|..||. |  |..|. .|.. | || ... ...|.  .|..| |. .|||||..        ||.|....|.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

ELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAY
 ||.|||...||||.. . .|.|..|.| |||..|.|.|..|...|| ..     |||||..|..|||.||||.|. | ||...|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCRVESI
|....|.
gwvlvsl

0051064 Phosphoglycerate mutase-like 260-452 5.7e-51 166.0 In-house 3-234 (241) alignment
Range on Protein: 260-452
Range on HMM: 3-234/241.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAE----ALR---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  |..|. .|.. | || ..  ....|  .|..| |. .|||||    ||    ||......|.||| |..| ||.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IRDTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEE
|....|||.... .|....|.                         | |||..|...|..|.. || ..     .||||..|..|.|.||||.|. . ||
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

MPYLKCPLHTVLKLTPVAYGCRVESIYLNVES
...|..| ..|..|.  ..|.||  ..||  |
llrlnlpngsvtvleldddgkrvvlvllndts

0043909 Phosphoglycerate mutase-like 260-443 6.6e-51 165.4 In-house 2-228 (249) alignment
Range on Protein: 260-443
Range on HMM: 2-228/249.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  ||.|. .|.. | || ... |....  .|..| || .|||||..        ||.|....|.|.| |..| ||..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IRDTYPEEYALREQ-----------------------------DKYYYRYPTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDK
|...||||.... .                             |....|.| |||..|.|.|..|...|| ..     .|||...|..|||.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

SAEEMPYLKCPLHTVLKLTPVAYGCRV
| |....|..| .....|.. ..|. |
sledilrlnlpngsitvlelddggkpv

0049178 Phosphoglycerate mutase-like 260-445 5.8e-50 162.4 In-house 3-225 (243) alignment
Range on Protein: 260-445
Range on HMM: 3-225/243.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  ||.|. .|.. | || ..  |..||  .|..| || .|||||..        ||......|.|.| |..| ||..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IRDTYPEEYALREQDKYYYRY-----------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEEMP
|.. ||||.... .|.|..|.                       | |||..|...|..|...|| ..     ..|||..|..|.|.|||..|. . ||..
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVLKLTPVAYGCRVES
.|..| ..|..|.   .|....|
rlnlpngsvtvlelddggwvlvs

0036887 Phosphoglycerate mutase-like 260-446 9.1e-49 158.0 In-house 1-195 (202) alignment
Range on Protein: 260-446
Range on HMM: 1-195/202.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEeqNLKDLRVWTSQLKSTIQTAEAL----RLPYEQWKALNEIDAGVCEELTYEEIRD
....||.|||| |.|..||. |  |..|. .|.. | || ...   .|.  .|..| |. .|||||..     ||......|.||| |..| ||.|||..
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

TYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQ---ENVLVICHQAVLRCLLAYFLDKSAEEMPYLK-CPLHTVLKLTPVAYGCRVESI
.||||.| . .|.|..|.| |||..|.|.|......|| ..   .||||..|..|||.||||.|. | |....|. .| ..|..|.  ..|......
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvll

0048955 Phosphoglycerate mutase-like 262-443 2.6e-48 157.3 In-house 2-222 (240) alignment
Range on Protein: 262-443
Range on HMM: 2-222/240.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAE----ALR---LPYEQWKALNEIDAGVCEELTYEEIR
..||.|||| |.|..||. |  |..|. .|.. | || ..  ....|  .|..| |. .|||||    ||    ||.... .|.|.| |..| ||..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

DTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELE-----RQENVLVICHQAVLRCLLAYFLDKSAEEMP
...|||..|. .|....|.                         | |||..|...|..... ||      ...||||..|..|.|.||||.|. . ||..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YLKCPLHTVLKLTPVAYGCRV
.|..| . |..|.   .. ..
rlnipngsvtvlelddglvsl

0050036 Phosphoglycerate mutase-like 262-434 2.6e-42 136.3 In-house 2-165 (171) alignment
Range on Protein: 262-434
Range on HMM: 2-165/171.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVeeqnlKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEey
..||.|||| |.||.||. |  |..|. .|.. | || ..      .  .|..| |. ..||||.. ||......|.|.| |..| ||..||...|||  
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

alREQDKYYYRYPTGESYQDLVQRLEPVIMELErqENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
  . .|......| |||..|...|. |.. ||   .||||..|..|.|.|||..|. |.||...|..| ..|| |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl

His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 Pfam-A 1-158 (158) alignment
Range on Protein: 262-409
Range on HMM: 1-158/158.0
TIYLCRHGENEHNLQGRIGGDSG--LSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRL----PYEQWKALNEIDAGVCEELTYEEIRDTY
..||.|||| |.| .||. |.|   |. .|.. | .| |  ....|.  .|.||.|| .|||||.|.     |... ..|.|.|.|..|.|..||.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELE----RQENVLVICHQAVLRCL
||||. . .||. .|.| |||..|...|..|...||     ..||||...|..|||.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 In-house 1-158 (158) alignment
Range on Protein: 262-409
Range on HMM: 1-158/158.0
TIYLCRHGENEHNLQGRIGGDSG--LSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRL----PYEQWKALNEIDAGVCEELTYEEIRDTY
..||.|||| |.| .||. |.|   |. .|.. | .| |  ....|.  .|.||.|| .|||||.|.     |... ..|.|.|.|..|.|..||.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELE----RQENVLVICHQAVLRCL
||||. . .||. .|.| |||..|...|..|...||     ..||||...|..|||.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

AAA_33 AAA domain 51-173 1.1e-10 32.1 Pfam-A 1-110 (143) alignment
Range on Protein: 51-173
Range on HMM: 1-110/143.0
VIVMVGLPARGKTYISKKLTRYLNWIGVPTKVfnvgeYRREAVKqyssynFFRPDNEEAMKVRKQCALAALRDVKSYLaKEGGQiAVFDATNTTRERRHM
....||||. ||.. ...| . | .. . . .     .||.  .        ... ..  .|.|..  . .. ....| ..|.. ...||||..||.|  
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg......tdqqsltdytrvlkrlyqilnklarkal.sagrs.vivdatnlsreerar

ILHFAKENDFKAFFIESVCDDPT
....||. ...   .   ... |
fvklakrlgvpvrivylevpeet

subfamily_TIGAR_pd Subfamily TIGAR 263-416 2.6e-09 29.1 In-house 3-176 (222) alignment
Range on Protein: 263-416
Range on HMM: 3-176/222.0
IYLCRHGENEHNLQGRIGGD--SGLSSRGKKFASALSKFVEEQNLKdlRVWTSQLKSTIQTAEALRLPY--------EQWKALNEIDAGVCEELTYEEIR
... |||| | | .. . |   . || .| . | ...|........  .. .| |. . ||||. . .         |. | | | . || |  ...|.|
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

DTYPEEYalreqDKYYYRYPTGESYQDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVLRCLLAYFLDK
.    .      .      . ||| . | .|| . . ||     ...             .|||..|...|| ||.... .
ellkaag.....nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhve

subfamily_PGAM_pd Subfamily PGAM 262-357 6e-09 27.6 In-house 2-106 (248) alignment
Range on Protein: 262-357
Range on HMM: 2-106/248.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL-------RLPYEQWKALNEIDAGVCEELTYEEIR
.. | |||| |.| . .. |  |  ||..||. | ...| ....||.   |.||.|| ..||.|..        .| |.   |||   |. . |  .|. 
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva

DTYPE
. | |
kkyGe

KTI12 Chromatin associated protein KTI12 52-181 2.3e-08 23.5 Pfam-A 4-117 (270) alignment
Range on Protein: 52-181
Range on HMM: 4-117/270.0
IVMVGLPARGKTYISKKLTRYLNWigvptkvfnvgE------YRREAVKqyssynfFRPDNEEAMKVRKQCALAALRDVKSYLAKEggQIAVFDATNTTR
.|. |||. ||. ..|.| ..|.            |       . |...       .. |. . .|  |.   .  ..||  | ||  .. . |..| ..
vvltGlPssGKstvakeLakalee...........egrsvvvisdeslg.......iekdsykdskkekalRsslrsavkrdLske..kvVIvDslnYik

ERRHMILHFAKENDFKAFFIESVCDDPTVVASNimE
  |  .   ||| . .   .. |..  |.|  |  |
gfRyeLyclakeakttlcvvyvvapletlvkwn..e

AAA_17 AAA domain 51-161 9.3e-08 23.5 Pfam-A 1-92 (121) alignment
Range on Protein: 51-161
Range on HMM: 1-92/121.0
VIVMVGLPARGKTYISKKLTRYLNWIgvptkVFNVGEY-RREAVKQYSsYNFFrpdneEAmkvrKQCALAALRDVKSYLA-KEGGQIAVFDAtntTRErR
||. .| |. ||....|.| ..|...     |.. ... |.|..|    ....     |.    |.. . .|...   || |..... |.|    ..|  
viaitGppGsGKsTlakeLaerlglp.....vlslddllreeglkeld.dger.....es....kdadadllaaildglaakkdtlswvidg...ale.v

HMILHFAkeNDFK
 . |...  ... 
eldlrle..eade

subfamily_TFC7_pd Subfamily TFC7 262-413 1.2e-06 19.3 In-house 2-177 (255) alignment
Range on Protein: 262-413
Range on HMM: 2-177/255.0
TIYLCRHGENEHNLQG--------RIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQT----AEALRLPYEQWKALNEI---D--AGVCE
|||..|||  .. |.          |  |  || || . |  |...... .||   . .| |.  ..|    ||.| .|    . . |    |    . |
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile

ELTYEEIRDTYPEEYAlREQDKYYYRYPTGESYQDLVQRLE---PVI-----MELERQENVLVICHQAVLRCLLAYF
 ...|...  .|.    .. .      ..||. ..| .|..   ||       . . .| .|.. | |    |   .
PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsl

subfamily_STS_pd Subfamily STS 281-412 3.9e-06 18.4 In-house 51-196 (245) alignment
Range on Protein: 281-412
Range on HMM: 51-196/245.0
GDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEqWKALNEIDAGVCEELTYEEIR-DTYPEEYALREQ----DKYY----YRY
 |. |..||.  |  | .   |...|   .. |    .||||.|.    .  |.  ... |..| | ...    ....  .| .     |. |      .
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls

P--TGESYQDLVQRLEPVIMEL----ERQENVLVICHQAVLRCLLAY
.  ..||...|..| . |. |.    ....|.|.. | | |  |   
elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldalsrq

Zeta_toxin Zeta toxin 47-98 5.9e-06 15.6 Pfam-A 14-62 (201) alignment
Range on Protein: 47-98
Range on HMM: 14-62/201.0
NSPTVIVMVGLPARGKTYISKKLTRYLNwiGVPTKVFNVGEYRREAvKQYSS
 .|......| |. |||.....| . |.  .  . ...  |.|..   .|..
ekpkavllgGqpGAGKtslaellleela..agnivridaDelrkfh.peyre

subfamily_PGAM_pd Subfamily PGAM 364-424 6.6e-06 17.6 In-house 140-205 (248) alignment
Range on Protein: 364-424
Range on HMM: 140-205/248.0
QDKYYYRYPTGESYQDLVQRLEPVIME-----LERQENVLVICHQAVLRCLLAYFLDKSAEEMPYL
...   ..|. || ...|.||.||. |     ......||.. |  ..|.|| .  . | |..  |
eelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaikel