Gene PFKFB3 in Homo sapiens

Synonym: IPFK2, PFK2, RP11-298K24.3, PFKFB3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP148_AA protein Get Run
HsapP148_AA_253-459 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 41-260 3.3e-110 356.8 Pfam-A 5-223 (223) alignment 
Range on Protein: 41-260
Range on HMM: 5-223/223.0
CGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDA
....|.||..|||.|||||||||||||||||||.|.||.|||||||.|||||||..|...|||||||||.|.|...|||||.|...||..|.||.|.|||
tvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDA

TNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDpDKCDRDLSLIKVIDVGRRFLVNR
||||||||..||.|..||..|..|.||||.|......||.|||.|||||||....||..||.||...||..|.||| |..|..||.|||||||....||.
tNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyepld.deedeelsyIkvidvgkslvvnn

VQDHIQSRIVYYLMNIHVQP
||...||||||||.|||..|
vqgylqsrivyyllNihlkp
subfamily_PFKFB_pd Subfamily PFKFB 255-450 3.9e-101 328.5 In-house 1-197 (198) alignment 
Range on Protein: 255-450
Range on HMM: 1-197/198.0
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDT
|||..||.|||.|||| |.| .||||||| |..||...|..|.||..|.|||.||||||.|| ||||||.|.||.||||||.|.|||.|..||||||...
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELER-QENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNV
.|||.. |..||| ||||.||||.||||||||||.|||| |||||.|.||||||.||||.|||||||.||||.|||||.|||||||||.||.. |.|
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
0035570 Phosphoglycerate mutase-like 262-459 9.8e-61 197.1 In-house 1-198 (219) alignment 
Range on Protein: 262-459
Range on HMM: 1-198/219.0
TIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYAL
..||.|||| |.||.||. ||..|. ||.. | || ..  .....  .|..| |. .|||||.. ||.|....|.|||.|..| ||..||...||||.|.
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

REQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER
. .|.|.||.| |||..|.|.|..|...|||..|||||..|..|.|.||||.|. ..||...|..| ..|..|.. ..|.... ..||  |. .....
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlellle
0039931 Phosphoglycerate mutase-like 262-451 7.7e-60 194.1 In-house 1-190 (219) alignment 
Range on Protein: 262-451
Range on HMM: 1-190/219.0
TIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYAL
..||.|||| |.|..||. |||.|. ||.. | || ..  ...|.  .|..| |. .|||||.. ||.|....|.|||.|..| ||.|||...||||.|.
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

REQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVE
. .|.|.||.| |||..|.|.|..|...||...|||||..|..|.|.||||.|. | ||...|..| ..|..|.. ..|.......|. .
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltsh
0053607 Phosphoglycerate mutase-like 260-445 4.7e-54 175.0 In-house 1-186 (191) alignment 
Range on Protein: 260-445
Range on HMM: 1-186/191.0
PRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEY
....||.|||| |.|..||. ||..|. .|.. | || ..  |..||  .|..| |. ..||||.. ||.|....|.|||.|..| ||.||....||||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVES
|.. .|...||.| |||..|...|..|...|| ...||||..|..|.|.||||.|. . ||...|..| ..|..|..  .|.....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvl
0036777 Phosphoglycerate mutase-like 260-452 1.3e-52 171.1 In-house 2-233 (247) alignment 
Range on Protein: 260-452
Range on HMM: 2-233/247.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  |..|. .|.. | || ... |..|.  .|..| |. .|||||..        ||......|.|.| |..| ||..|
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

IRDTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEE
|...||||.... .|.|.||.                         | |||..|.|.|..|...|| ..     |||||..|..|||.||||.|. | |.
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

MPYLKCPLHTVLKLTPVAYGCRVESIYLNVES
...|..| .....|.  ..| ..  ..||  |
ilrlnlpngsitvleldddgklwvleslndts
0037864 Phosphoglycerate mutase-like 254-446 6.2e-52 168.3 In-house 1-207 (211) alignment 
Range on Protein: 254-446
Range on HMM: 1-207/211.0
MNIHVQPRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCE
|.........||.|||| |.|..||. |  |..|. .|.. | || ... ...|.  .|..| |. .|||||..        ||.|....|.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

ELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAY
 ||.|||...||||.. . .|.|..|.| |||..|.|.|..|...|| ..     |||||..|..|||.||||.|. | ||...|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCRVESI
|....|.
gwvlvsl
0051064 Phosphoglycerate mutase-like 260-452 5.7e-51 166.0 In-house 3-234 (241) alignment 
Range on Protein: 260-452
Range on HMM: 3-234/241.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAE----ALR---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  |..|. .|.. | || ..  ....|  .|..| |. .|||||    ||    ||......|.||| |..| ||.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IRDTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEE
|....|||.... .|....|.                         | |||..|...|..|.. || ..     .||||..|..|.|.||||.|. . ||
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

MPYLKCPLHTVLKLTPVAYGCRVESIYLNVES
...|..| ..|..|.  ..|.||  ..||  |
llrlnlpngsvtvleldddgkrvvlvllndts
0043909 Phosphoglycerate mutase-like 260-443 6.6e-51 165.4 In-house 2-228 (249) alignment 
Range on Protein: 260-443
Range on HMM: 2-228/249.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  ||.|. .|.. | || ... |....  .|..| || .|||||..        ||.|....|.|.| |..| ||..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IRDTYPEEYALREQ-----------------------------DKYYYRYPTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDK
|...||||.... .                             |....|.| |||..|.|.|..|...|| ..     .|||...|..|||.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

SAEEMPYLKCPLHTVLKLTPVAYGCRV
| |....|..| .....|.. ..|. |
sledilrlnlpngsitvlelddggkpv
0049178 Phosphoglycerate mutase-like 260-445 5.8e-50 162.4 In-house 3-225 (243) alignment 
Range on Protein: 260-445
Range on HMM: 3-225/243.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL----R---LPYEQWKALNEIDAGVCEELTYEE
....||.|||| |.|..||. |  ||.|. .|.. | || ..  |..||  .|..| || .|||||..        ||......|.|.| |..| ||..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IRDTYPEEYALREQDKYYYRY-----------------------PTGESYQDLVQRLEPVIMELERQ-----ENVLVICHQAVLRCLLAYFLDKSAEEMP
|.. ||||.... .|.|..|.                       | |||..|...|..|...|| ..     ..|||..|..|.|.|||..|. . ||..
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVLKLTPVAYGCRVES
.|..| ..|..|.   .|....|
rlnlpngsvtvlelddggwvlvs
0036887 Phosphoglycerate mutase-like 260-446 9.1e-49 158.0 In-house 1-195 (202) alignment 
Range on Protein: 260-446
Range on HMM: 1-195/202.0
PRTIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEeqNLKDLRVWTSQLKSTIQTAEAL----RLPYEQWKALNEIDAGVCEELTYEEIRD
....||.|||| |.|..||. |  |..|. .|.. | || ...   .|.  .|..| |. .|||||..     ||......|.||| |..| ||.|||..
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

TYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQ---ENVLVICHQAVLRCLLAYFLDKSAEEMPYLK-CPLHTVLKLTPVAYGCRVESI
.||||.| . .|.|..|.| |||..|.|.|......|| ..   .||||..|..|||.||||.|. | |....|. .| ..|..|.  ..|......
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvll
0048955 Phosphoglycerate mutase-like 262-443 2.6e-48 157.3 In-house 2-222 (240) alignment 
Range on Protein: 262-443
Range on HMM: 2-222/240.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAE----ALR---LPYEQWKALNEIDAGVCEELTYEEIR
..||.|||| |.|..||. |  |..|. .|.. | || ..  ....|  .|..| |. .|||||    ||    ||.... .|.|.| |..| ||..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

DTYPEEYALREQDKYYYRY-------------------------PTGESYQDLVQRLEPVIMELE-----RQENVLVICHQAVLRCLLAYFLDKSAEEMP
...|||..|. .|....|.                         | |||..|...|..... ||      ...||||..|..|.|.||||.|. . ||..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YLKCPLHTVLKLTPVAYGCRV
.|..| . |..|.   .. ..
rlnipngsvtvlelddglvsl
0050036 Phosphoglycerate mutase-like 262-434 2.6e-42 136.3 In-house 2-165 (171) alignment 
Range on Protein: 262-434
Range on HMM: 2-165/171.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVeeqnlKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEey
..||.|||| |.||.||. |  |..|. .|.. | || ..      .  .|..| |. ..||||.. ||......|.|.| |..| ||..||...|||  
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

alREQDKYYYRYPTGESYQDLVQRLEPVIMELErqENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
  . .|......| |||..|...|. |.. ||   .||||..|..|.|.|||..|. |.||...|..| ..|| |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 Pfam-A 1-158 (158) alignment 
Range on Protein: 262-409
Range on HMM: 1-158/158.0
TIYLCRHGENEHNLQGRIGGDSG--LSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRL----PYEQWKALNEIDAGVCEELTYEEIRDTY
..||.|||| |.| .||. |.|   |. .|.. | .| |  ....|.  .|.||.|| .|||||.|.     |... ..|.|.|.|..|.|..||.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELE----RQENVLVICHQAVLRCL
||||. . .||. .|.| |||..|...|..|...||     ..||||...|..|||.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 In-house 1-158 (158) alignment 
Range on Protein: 262-409
Range on HMM: 1-158/158.0
TIYLCRHGENEHNLQGRIGGDSG--LSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRL----PYEQWKALNEIDAGVCEELTYEEIRDTY
..||.|||| |.| .||. |.|   |. .|.. | .| |  ....|.  .|.||.|| .|||||.|.     |... ..|.|.|.|..|.|..||.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELE----RQENVLVICHQAVLRCL
||||. . .||. .|.| |||..|...|..|...||     ..||||...|..|||.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
AAA_33 AAA domain 51-173 1.1e-10 32.1 Pfam-A 1-110 (143) alignment 
Range on Protein: 51-173
Range on HMM: 1-110/143.0
VIVMVGLPARGKTYISKKLTRYLNWIGVPTKVfnvgeYRREAVKqyssynFFRPDNEEAMKVRKQCALAALRDVKSYLaKEGGQiAVFDATNTTRERRHM
....||||. ||.. ...| . | .. . . .     .||.  .        ... ..  .|.|..  . .. ....| ..|.. ...||||..||.|  
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg......tdqqsltdytrvlkrlyqilnklarkal.sagrs.vivdatnlsreerar

ILHFAKENDFKAFFIESVCDDPT
....||. ...   .   ... |
fvklakrlgvpvrivylevpeet
subfamily_TIGAR_pd Subfamily TIGAR 263-416 2.6e-09 29.1 In-house 3-176 (222) alignment 
Range on Protein: 263-416
Range on HMM: 3-176/222.0
IYLCRHGENEHNLQGRIGGD--SGLSSRGKKFASALSKFVEEQNLKdlRVWTSQLKSTIQTAEALRLPY--------EQWKALNEIDAGVCEELTYEEIR
... |||| | | .. . |   . || .| . | ...|........  .. .| |. . ||||. . .         |. | | | . || |  ...|.|
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

DTYPEEYalreqDKYYYRYPTGESYQDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVLRCLLAYFLDK
.    .      .      . ||| . | .|| . . ||     ...             .|||..|...|| ||.... .
ellkaag.....nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhve
subfamily_PGAM_pd Subfamily PGAM 262-357 6e-09 27.6 In-house 2-106 (248) alignment 
Range on Protein: 262-357
Range on HMM: 2-106/248.0
TIYLCRHGENEHNLQGRIGG--DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEAL-------RLPYEQWKALNEIDAGVCEELTYEEIR
.. | |||| |.| . .. |  |  ||..||. | ...| ....||.   |.||.|| ..||.|..        .| |.   |||   |. . |  .|. 
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva

DTYPE
. | |
kkyGe
KTI12 Chromatin associated protein KTI12 52-181 2.3e-08 23.5 Pfam-A 4-117 (270) alignment 
Range on Protein: 52-181
Range on HMM: 4-117/270.0
IVMVGLPARGKTYISKKLTRYLNWigvptkvfnvgE------YRREAVKqyssynfFRPDNEEAMKVRKQCALAALRDVKSYLAKEggQIAVFDATNTTR
.|. |||. ||. ..|.| ..|.            |       . |...       .. |. . .|  |.   .  ..||  | ||  .. . |..| ..
vvltGlPssGKstvakeLakalee...........egrsvvvisdeslg.......iekdsykdskkekalRsslrsavkrdLske..kvVIvDslnYik

ERRHMILHFAKENDFKAFFIESVCDDPTVVASNimE
  |  .   ||| . .   .. |..  |.|  |  |
gfRyeLyclakeakttlcvvyvvapletlvkwn..e
AAA_17 AAA domain 51-161 9.3e-08 23.5 Pfam-A 1-92 (121) alignment 
Range on Protein: 51-161
Range on HMM: 1-92/121.0
VIVMVGLPARGKTYISKKLTRYLNWIgvptkVFNVGEY-RREAVKQYSsYNFFrpdneEAmkvrKQCALAALRDVKSYLA-KEGGQIAVFDAtntTRErR
||. .| |. ||....|.| ..|...     |.. ... |.|..|    ....     |.    |.. . .|...   || |..... |.|    ..|  
viaitGppGsGKsTlakeLaerlglp.....vlslddllreeglkeld.dger.....es....kdadadllaaildglaakkdtlswvidg...ale.v

HMILHFAkeNDFK
 . |...  ... 
eldlrle..eade
subfamily_TFC7_pd Subfamily TFC7 262-413 1.2e-06 19.3 In-house 2-177 (255) alignment 
Range on Protein: 262-413
Range on HMM: 2-177/255.0
TIYLCRHGENEHNLQG--------RIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQT----AEALRLPYEQWKALNEI---D--AGVCE
|||..|||  .. |.          |  |  || || . |  |...... .||   . .| |.  ..|    ||.| .|    . . |    |    . |
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile

ELTYEEIRDTYPEEYAlREQDKYYYRYPTGESYQDLVQRLE---PVI-----MELERQENVLVICHQAVLRCLLAYF
 ...|...  .|.    .. .      ..||. ..| .|..   ||       . . .| .|.. | |    |   .
PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsl
subfamily_STS_pd Subfamily STS 281-412 3.9e-06 18.4 In-house 51-196 (245) alignment 
Range on Protein: 281-412
Range on HMM: 51-196/245.0
GDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEqWKALNEIDAGVCEELTYEEIR-DTYPEEYALREQ----DKYY----YRY
 |. |..||.  |  | .   |...|   .. |    .||||.|.    .  |.  ... |..| | ...    ....  .| .     |. |      .
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls

P--TGESYQDLVQRLEPVIMEL----ERQENVLVICHQAVLRCLLAY
.  ..||...|..| . |. |.    ....|.|.. | | |  |   
elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldalsrq
Zeta_toxin Zeta toxin 47-98 5.9e-06 15.6 Pfam-A 14-62 (201) alignment 
Range on Protein: 47-98
Range on HMM: 14-62/201.0
NSPTVIVMVGLPARGKTYISKKLTRYLNwiGVPTKVFNVGEYRREAvKQYSS
 .|......| |. |||.....| . |.  .  . ...  |.|..   .|..
ekpkavllgGqpGAGKtslaellleela..agnivridaDelrkfh.peyre
subfamily_PGAM_pd Subfamily PGAM 364-424 6.6e-06 17.6 In-house 140-205 (248) alignment 
Range on Protein: 364-424
Range on HMM: 140-205/248.0
QDKYYYRYPTGESYQDLVQRLEPVIME-----LERQENVLVICHQAVLRCLLAYFLDKSAEEMPYL
...   ..|. || ...|.||.||. |     ......||.. |  ..|.|| .  . | |..  |
eelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaikel