Gene PFKFB3 in Homo sapiens

Synonym: IPFK2, PFK2, RP11-298K24.3, PFKFB3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP148_AA protein Get Run
HsapP148_AA_253-459 phosphatase_domain Get Run
Domains
Summary
100200300400500MGEGGQKEGDSQQAGALPLLCQLDTFSPKATVFGVSINPACGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKHHP1Curated phosphatase domainD6PF2KHis_Phos_1Pfam Domainsubfamily_PFKFB_pd(1)0035570(2)0039931(3)0053607(4)0036777(5)Subfamily
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 41-260 3.3e-110 356.8 Pfam-A 5-223 (223) alignment
subfamily_PFKFB_pd Subfamily PFKFB 255-450 3.9e-101 328.5 In-house 1-197 (198) alignment
0035570 Phosphoglycerate mutase-like 262-459 9.8e-61 197.1 In-house 1-198 (219) alignment
0039931 Phosphoglycerate mutase-like 262-451 7.7e-60 194.1 In-house 1-190 (219) alignment
0053607 Phosphoglycerate mutase-like 260-445 4.7e-54 175.0 In-house 1-186 (191) alignment
0036777 Phosphoglycerate mutase-like 260-452 1.3e-52 171.1 In-house 2-233 (247) alignment
0037864 Phosphoglycerate mutase-like 254-446 6.2e-52 168.3 In-house 1-207 (211) alignment
0051064 Phosphoglycerate mutase-like 260-452 5.7e-51 166.0 In-house 3-234 (241) alignment
0043909 Phosphoglycerate mutase-like 260-443 6.6e-51 165.4 In-house 2-228 (249) alignment
0049178 Phosphoglycerate mutase-like 260-445 5.8e-50 162.4 In-house 3-225 (243) alignment
0036887 Phosphoglycerate mutase-like 260-446 9.1e-49 158.0 In-house 1-195 (202) alignment
0048955 Phosphoglycerate mutase-like 262-443 2.6e-48 157.3 In-house 2-222 (240) alignment
0050036 Phosphoglycerate mutase-like 262-434 2.6e-42 136.3 In-house 2-165 (171) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 Pfam-A 1-158 (158) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 262-409 1.8e-36 118.5 In-house 1-158 (158) alignment
AAA_33 AAA domain 51-173 1.1e-10 32.1 Pfam-A 1-110 (143) alignment
subfamily_TIGAR_pd Subfamily TIGAR 263-416 2.6e-09 29.1 In-house 3-176 (222) alignment
subfamily_PGAM_pd Subfamily PGAM 262-357 6e-09 27.6 In-house 2-106 (248) alignment
KTI12 Chromatin associated protein KTI12 52-181 2.3e-08 23.5 Pfam-A 4-117 (270) alignment
AAA_17 AAA domain 51-161 9.3e-08 23.5 Pfam-A 1-92 (121) alignment
subfamily_TFC7_pd Subfamily TFC7 262-413 1.2e-06 19.3 In-house 2-177 (255) alignment
subfamily_STS_pd Subfamily STS 281-412 3.9e-06 18.4 In-house 51-196 (245) alignment
Zeta_toxin Zeta toxin 47-98 5.9e-06 15.6 Pfam-A 14-62 (201) alignment
subfamily_PGAM_pd Subfamily PGAM 364-424 6.6e-06 17.6 In-house 140-205 (248) alignment