Gene PFKFB4 in Homo sapiens

Synonym: PFKFB4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP149_AA protein Get Run
HsapP149_AA_242-466 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 35-249 2.1e-105 341.0 Pfam-A 9-223 (223) alignment 
Range on Protein: 35-249
Range on HMM: 9-223/223.0
MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTT
..|....||.|||||||||||||||||||.|.||.|. ||||.|||..||.....||| |||||.||.|...|||||.|....|.||.|.||.|||||||
lknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtNtt

RERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHI
||||..|..| |.|..|..|.||.| |.|.|..|| .|||.|||| .....||..||..|.|.||..||.||.. |..|||||..|||.|.|||.|....
rerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqgyl

QSRIVYYLMNIHVTP
||||||||.|||..|
qsrivyyllNihlkp
subfamily_PFKFB_pd Subfamily PFKFB 244-439 2.9e-103 335.5 In-house 1-197 (198) alignment 
Range on Protein: 244-439
Range on HMM: 1-197/198.0
NIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDN
|||..||.|||.|||||| | |||||||  |..||.|.||.||.||...|.|.|.||||..||||||||.||.|.||||.|.|.|||.|...|||||...
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELER-QENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNV
.| ||. |..||||||||.|||||||||||||||.|||| |||||.|.||||.|.||||.||| ||.|||||.|||||.||||||||||||.. |.|
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
0035570 Phosphoglycerate mutase-like 252-466 1.9e-64 209.2 In-house 2-216 (219) alignment 
Range on Protein: 252-466
Range on HMM: 2-216/219.0
IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR
.||.||||.| ||.||. ||..|..|||| |. |.....|..|.  .|..| ..|.|||||..|.|.|... |.|||.|..| .|..||.. || |.|..
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN
 .|.|.||.|.|||..|.|.|..|...|||..|||||..|..|.|.||||.|.  .|....|..| ..|..|.. ..|.|.. ..||  .. ... .. .
lrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllelll

VDISRPPEEALVTVP
... ....  |..||
lslllvealllldvp
0039931 Phosphoglycerate mutase-like 252-456 8.5e-63 203.8 In-house 2-206 (219) alignment 
Range on Protein: 252-456
Range on HMM: 2-206/219.0
IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR
.||.||||.| |..||. ||..|..|||| |. |.....|....   |..| ..|.|||||..|.|.|... |.|||.|..| .|.|||...|| |.|..
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN
 .|.|.||.|.|||..|.|.|..|...||...|||||..|..|.|.||||.|.   |....|..| ..|..|.. ..|...... |.    ...| .. .
lrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllllt

VDISR
... .
lelll
0053607 Phosphoglycerate mutase-like 249-433 4.8e-56 181.4 In-house 1-185 (191) alignment 
Range on Protein: 249-433
Range on HMM: 1-185/191.0
PRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEF
.. .||.||||.| |..||. ||..|...||| |. ||... ....|  .|..| ..|..||||..|.|.|... |.|||.|..| .|.||....|| |.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVE
|.. .|.. ||.|.|||..|...|..|...|| ...||||..|..|.|.||||.|.   |.|..|..| ..|..|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0036777 Phosphoglycerate mutase-like 250-438 4.7e-54 175.8 In-house 3-230 (247) alignment 
Range on Protein: 250-438
Range on HMM: 3-230/247.0
RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEI
. .||.||||.| |. ||. |  |..|...||| || |..........  .|..| ..|.|||||    |||   .|..... |.|.| |..| .|..||
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

QDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQL
.. || |.... .|.| ||.                         | |||..|.|.|..|...|| ..     |||||..|..|.|.||||.|.   |..
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

PYLKCPLHTVLKLTPVAYGCKVESIFLN
..|..| .....|.  ..| ..  ..||
lrlnlpngsitvleldddgklwvlesln
0037864 Phosphoglycerate mutase-like 243-434 5.1e-54 175.1 In-house 1-206 (211) alignment 
Range on Protein: 243-434
Range on HMM: 1-206/211.0
MNIHVTPRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCE
|....... .||.||||.| |..||. |  |..|...||| |. |.... |....   |..| ..|.|||||..    |   .|.|... |.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

EMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAY
 .|.|||.. || |.. . .|.| .|.|.|||..|.|.|..|...|| ..     |||||..|..|.|.||||.|.   |.|..|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKVES
|....|
gwvlvs
0043909 Phosphoglycerate mutase-like 249-432 3.7e-53 172.8 In-house 2-228 (249) alignment 
Range on Protein: 249-432
Range on HMM: 2-228/249.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.||||.| |..||. |  |..|...||| |. |........|.  .|..| .||.|||||    .||   .|.|... |.|.| |..| .|..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQDNYPLEFALRDQ-----------------------------DKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDK
| . || |.... .                             |.. .|.|.|||..|.|.|..|...|| ..     .|||...|..|.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

AAEQLPYLKCPLHTVLKLTPVAYGCKV
  |....|..| .....|.. ..|..|
sledilrlnlpngsitvlelddggkpv
0051064 Phosphoglycerate mutase-like 249-439 8.9e-53 171.9 In-house 3-232 (241) alignment 
Range on Protein: 249-439
Range on HMM: 3-232/241.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.|||||| |. ||. |  |..|...||| |. |.....|..||  .|..| ..|.|||||    |||   .|..... |.||| |..| .|.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQ
|.. .| |......|.. .|.                         | |||..|...|..|.. || ..     .||||..|..|.|.||||.|.   |.
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLKCPLHTVLKLTPVAYGCKVESIFLNV
|..|..| ..|..|.  ..|..|  ..|| 
llrlnlpngsvtvleldddgkrvvlvllnd
0049178 Phosphoglycerate mutase-like 249-433 7.3e-52 168.7 In-house 3-224 (243) alignment 
Range on Protein: 249-433
Range on HMM: 3-224/243.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.||||.| |..||. |  |..|...||| |. |.........|   |..| .||.|||||..    |   .|..... |.|.| |..| .|..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQDNYPLEFALRDQDKYRYRY-----------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLP
|...|| |.... .|.| .|.                       | |||..|...|..|...|| ..     ..|||..|..|.|.|||..|.   |.|.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVLKLTPVAYGCKVE
.|..| ..|..|.   .|....
rlnlpngsvtvlelddggwvlv
0048955 Phosphoglycerate mutase-like 252-428 2.4e-51 167.2 In-house 3-218 (240) alignment 
Range on Protein: 252-428
Range on HMM: 3-218/240.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEIQD
.||.|||||| |..||. |  |..|...||| |. |.....|..||  .|..| ..|.|||||    |||   .|....  |.|.| |..| .|..||..
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

NYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELE-----RQENVLVICHQAVMRCLLAYFLDKAAEQLPY
..| |..|. .|.. .|.                         | |||..|...|..... ||      ...||||..|..|.|.||||.|.   |....
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr

LKCPLHTVLKLTPVAY
|..| . |..|.   .
lnipngsvtvlelddg
0036887 Phosphoglycerate mutase-like 250-434 3.1e-51 166.1 In-house 2-194 (202) alignment 
Range on Protein: 250-434
Range on HMM: 2-194/202.0
RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISdqNIKDLKVWTSQMKRTIQTAEAL----GVPYEQWKVLNEIDAGVCEEMTYEEIQDN
. .||.||||.| |..||. |  |..|...||| |. |.....  ...   |..| ..|.|||||..    |.|..... |.||| |..| .|.|||.. 
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ---ENVLVICHQAVMRCLLAYFLDKAAEQLPYLK-CPLHTVLKLTPVAYGCKVES
|| |.| . .|.| .|.|.|||..|.|.|......|| ..   .||||..|..|.|.||||.|.   |.|..|. .| ..|..|.  ..|.....
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
0050036 Phosphoglycerate mutase-like 252-423 7.1e-44 141.3 In-house 3-165 (171) alignment 
Range on Protein: 252-423
Range on HMM: 3-165/171.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFIsdqniKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLefa
.||.||||.| ||.||. |  |..|...||. |. |....     .   |..| ..|..||||....|..... |.|.| |..| .|..||.. ||    
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype...

lRDQDKYRYRYPKGESYEDLVQRLEPVIMELErqENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKL
 ...|......| |||..|...|. |.. ||   .||||..|..|.|.|||..|.  .|....|..| ..|| |
.wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 252-398 5.4e-39 126.6 Pfam-A 2-158 (158) alignment 
Range on Protein: 252-398
Range on HMM: 2-158/158.0
IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP
.||.||||||.| .||. |.    |...||| |..|.. .......  .|.||..||.|||||.|     .|... . |.|.|.|..|....||.....|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
 |.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 252-398 5.4e-39 126.6 In-house 2-158 (158) alignment 
Range on Protein: 252-398
Range on HMM: 2-158/158.0
IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP
.||.||||||.| .||. |.    |...||| |..|.. .......  .|.||..||.|||||.|     .|... . |.|.|.|..|....||.....|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
 |.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_TIGAR_pd Subfamily TIGAR 251-404 6.8e-12 37.5 In-house 2-175 (222) alignment 
Range on Protein: 251-404
Range on HMM: 2-175/222.0
SIYLCRHGESELNLKGRIGGD--PGLSPRGREFAKSLAQFISDQNIKdlKVWTSQMKRTIQTAEALG--------VPYEQWKVLNEIDAGVCEEMTYEEI
.... ||||.| | .. . |     ||..|.| ||..|...|...|.   . .|  .|. ||||.           . |. | | | . || | ....|.
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

QDNYpleFALRdqDKYRYRYPKGESYEDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVMRCLLAYFLD
..     .| .  .  .   . ||| | | .|| . . ||     ...             .|||..|....| ||.... 
rell...kaag..nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhv
subfamily_PGAM_pd Subfamily PGAM 252-333 8.3e-12 36.9 In-house 3-93 (248) alignment 
Range on Protein: 252-333
Range on HMM: 3-93/248.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL-------GVPYEQWKVLNEIDAGVCE
. | |||||||| . .. |  |  ||..|.| || ... . ..|..  .|.||..||..||.|..        .| |.   |||   |. .
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGalt
AAA_33 AAA domain 41-196 1.3e-11 35.0 Pfam-A 1-141 (143) alignment 
Range on Protein: 41-196
Range on HMM: 1-141/143.0
LIVMVGLPARGKTYISKKLTRYLNWIGVPTREfnvgqYRRDVVKtyksfefF-----LpdneEGLKIRKQCALAALRDVRRFLsEEGGHvAVFDATNTTR
|...||||. ||.. ...| . | .. . . .     .|| . .                  .  . .|..  . .. .|. | ..|.. ...||||..|
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg.......tdqqslt....dytrvlkrlyqilnklarkal.sagrs.vivdatnlsr

ERRATIFNFGEQNGYKTFFVeSICVDPEVIAANIVQVKLGSPDYVNrDSDEATEDFMRRIE
|.|| . .. .. |..   |  . |..|..|... . .  . | ..   .|| ... .|.|
eerarfvklakrlgvpvriv.ylevpeetlaeRlakRerngddrse.vpeealdrmlarfe
subfamily_STS_pd Subfamily STS 270-398 3e-10 31.9 In-house 51-193 (245) alignment 
Range on Protein: 270-398
Range on HMM: 51-193/245.0
GDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEqWKVLNEIDAGVCEEMTYEEIQ------DNYPLEFALRDQDKYR-----Y
 || |. ||   || |.. .....||   .. | . |.||||.|.    .  |.  ... |..| . ... .       .   .| .. . .|.     .
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls

RYPKGESYEDLVQRLEPVIMEL----ERQENVLVICHQAVMRCL
.  ..||.|.|..| . |. |.    ....|.|.. | | .  |
elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal
subfamily_TFC7_pd Subfamily TFC7 252-403 2.1e-09 28.4 In-house 3-178 (255) alignment 
Range on Protein: 252-403
Range on HMM: 3-178/255.0
IYLCRHGESELN---------LKGrIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTA----EALGVPYEQWK-VLNEID----AGVCE
||..|||  .           |.| |  |. || || | || ||....  ..|   . .| ..| ..|.    |.| .|    . | . .       . |
iyiarhGyrsnwlpkgpypdpltg.idsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile

EMTYEEIQDNYPLEFAlRDQDKYRYRYPKGESYEDLVQRLE---PV-----IMELERQENVLVICHQAVMRCLLAYFL
 ...|...  .|     .| .      .|||. |.| .|..   ||     . . . .| .|.. | | .  |   .|
PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll
0053031 Phosphoglycerate mutase-like 252-385 2.6e-08 26.7 In-house 7-164 (342) alignment 
Range on Protein: 252-385
Range on HMM: 7-164/342.0
IYLCRHG----ESELNLKGRI-----GGDPGLSPRGREFAKSLAQFISDQ---------NIKDLKVWTSQMKRTIQTAEALGV---PYEQWKVLNEIDAG
|.| |||    .| ..|  ..      |.. |.|.||| |. | ... .          | ....|..| . ||.|.|.|.     | | ...|| .   
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgw

VCEEMTYEEIQDNYPL---EFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQEN
.  .. .|.   .. |          ||.. .....| ...| .|..... .| .  .
qpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglg
Prefoldin Prefoldin subunit 148-211 1.2e-07 17.8 Pfam-A 37-102 (120) alignment 
Range on Protein: 148-211
Range on HMM: 37-102/120.0
NGYKTFF--VESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDR
.|.....   ... |  ||.  . | |.||.  || ....||.| . ...| .|.. |.| |.|. 
egkevlvplgaglyvkaevkdtdkvlvdlGagyyveksleeAiellkkkleelekqlekleeelek
0047369 Phosphoglycerate mutase-like 252-342 3.3e-07 22.9 In-house 48-175 (438) alignment 
Range on Protein: 252-342
Range on HMM: 48-175/438.0
IYLCRHGES-----------------------------ELNLKGRIGGDPGLSPRGREFAKSLAQFISDQ----NIKDL-KVWTSQMKRTIQTAEALGV-
..| |||.                               ||    . | . |.|.||| |. | ... .     | .|. .|..| . ||.|.|.|.   
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqaflaG

--PYEQWKVLNEIDAGVCEEMTYEEIQD
  | | ...|..|   .    |  | .|
lfppegtgelapilwqpipihtipesdd
0049059 Phosphoglycerate mutase-like 252-315 4.7e-07 22.2 In-house 47-144 (435) alignment 
Range on Protein: 252-315
Range on HMM: 47-144/435.0
IYLCRHGE-----------------------------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD-----QNIKDLKVWTSQMKRTIQTAEALG
..| |||.                             |.||    . |.. |.|.||| |. |.... .      | ....|..| . ||.|.|.|. 
qvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl
KTI12 Chromatin associated protein KTI12 41-160 1.1e-06 18.0 Pfam-A 3-108 (270) alignment 
Range on Protein: 41-160
Range on HMM: 3-108/270.0
LIVMVGLPARGKTYISKKLTRYLNWigvptREFNVGQYRRDVVKtYKSFEFFLPDNEEglKIRKQcalaALRDVRRFLSEEggHVAVFDATNTTRERRAT
|.|. |||. ||. ..|.| ..|.      .. .|   . . ..  .. ..    .|.  ..|..      ..|.| ||.|  .| . |..| ..  |  
LvvltGlPssGKstvakeLakalee.....egrsvvvisdeslg.iekdsykdskkek..alRss....lrsavkrdLske..kvVIvDslnYikgfRye

IFNFGEQNGYKTFFVESICV
...   .   .   |. .. 
Lyclakeakttlcvvyvvap
0048439 Phosphoglycerate mutase-like 252-373 2.2e-06 20.4 In-house 13-169 (391) alignment 
Range on Protein: 252-373
Range on HMM: 13-169/391.0
IYLCRHG------------ESELNLKGRI--GGDPGLSPRGREFAKSLAQFISD----------Q---NIKDLKVWTSQMKRTIQTAEALGV---PYEQW
..| |||            .  ||.  ..   |.. |.|.||| .  | ... .          .   | ....|..| . ||.|.|.|.     | ...
qvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgl

KVLNEIDAGVCEEMTYEEIQDNYPL-----EFALRDQDKYRYRYPKGESYEDLVQRL
.|.. |..   ... .. . . .||       . ...  . |  ...|.......|.
tvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrv
0046349 Phosphoglycerate mutase-like 252-330 4.5e-06 19.2 In-house 11-118 (409) alignment 
Range on Protein: 252-330
Range on HMM: 11-118/409.0
IYLCRHGE----------SELNLKGRIGGD---PGLSPRGREFAKSLAQFISD-------------QNIKDLKVWTSQMKRTIQTAEALGV---PYEQWK
..| |||.           . ... .. |.   . |.|.||| |  | ... .              | ....|..| . ||.|.|.|.     | ....
qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplgge

VLNEIDAG
.   .. .
ivpllrqd
subfamily_PGAM5_pd Subfamily PGAM5 250-399 5.6e-06 17.6 In-house 2-142 (189) alignment 
Range on Protein: 250-399
Range on HMM: 2-142/189.0
RSIYLCRHGESELNLKgriGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEiDAGVCEEMTyeeIQDNYPLEFA
| . | |||. .|. .     .  |...||. |. . . . . |.|  |. .| | |...||. .    .. ..  .  . ..|      |. . . .  
rhlilvrhgqyvlddd...sdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk.tellreGaP...ikpePavkhw

LRDQDKYRYRYPKGE-SYEDLVQRLEPvimELERQENVLVICHQAVMRCLL
  .. ..    .. | ..  .. | .|   | ...   |..||  |.| |.
kpealqfyedgarieaafrkyfhrasp...eqkedsyelivchanvirylv
AAA_17 AAA domain 42-100 7.8e-06 17.3 Pfam-A 2-58 (121) alignment 
Range on Protein: 42-100
Range on HMM: 2-58/121.0
IVMVGLPARGKTYISKKLTRYLNWIGvptreFNVGQ--YRRDVVKTYKSF-EFFLPDNEEGL
|. .| |. ||....|.| ..|...      .. ..  ..... .. . . |..  |...  
iaitGppGsGKsTlakeLaerlglpv.....lslddllreeglkelddgereskdadadlla
subfamily_PGAM_pd Subfamily PGAM 354-403 8.3e-06 17.3 In-house 141-195 (248) alignment 
Range on Protein: 354-403
Range on HMM: 141-195/248.0
DKYRYRYPKGESYEDLVQRLEPVIME-----LERQENVLVICHQAVMRCLLAYFL
.. . ..|. || ...|.||.||. |     ......||.. |  ..|.|| .  
elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvle
0049226 Phosphoglycerate mutase-like 252-316 9.3e-06 18.2 In-house 7-89 (342) alignment 
Range on Protein: 252-316
Range on HMM: 7-89/342.0
IYLCRHGE---------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD---------QNIKDLKVWTSQMKRTIQTAEALGV
..| |||.         ..|| .    |.. |.|.||| |  |.... .          | ....|..| . ||.|.|.|.  
qvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqafla