Gene PFKFB4 in Homo sapiens

Synonym: PFKFB4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP149_AA protein Get Run
HsapP149_AA_242-466 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 35-249 2.1e-105 341.0 Pfam-A 9-223 (223) alignment
Range on Protein: 35-249
Range on HMM: 9-223/223.0
MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTT
..|....||.|||||||||||||||||||.|.||.|. ||||.|||..||.....||| |||||.||.|...|||||.|....|.||.|.||.|||||||
lknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtNtt

RERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHI
||||..|..| |.|..|..|.||.| |.|.|..|| .|||.|||| .....||..||..|.|.||..||.||.. |..|||||..|||.|.|||.|....
rerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqgyl

QSRIVYYLMNIHVTP
||||||||.|||..|
qsrivyyllNihlkp

subfamily_PFKFB_pd Subfamily PFKFB 244-439 2.9e-103 335.5 In-house 1-197 (198) alignment
Range on Protein: 244-439
Range on HMM: 1-197/198.0
NIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDN
|||..||.|||.|||||| | |||||||  |..||.|.||.||.||...|.|.|.||||..||||||||.||.|.||||.|.|.|||.|...|||||...
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELER-QENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNV
.| ||. |..||||||||.|||||||||||||||.|||| |||||.|.||||.|.||||.||| ||.|||||.|||||.||||||||||||.. |.|
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv

0035570 Phosphoglycerate mutase-like 252-466 1.9e-64 209.2 In-house 2-216 (219) alignment
Range on Protein: 252-466
Range on HMM: 2-216/219.0
IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR
.||.||||.| ||.||. ||..|..|||| |. |.....|..|.  .|..| ..|.|||||..|.|.|... |.|||.|..| .|..||.. || |.|..
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN
 .|.|.||.|.|||..|.|.|..|...|||..|||||..|..|.|.||||.|.  .|....|..| ..|..|.. ..|.|.. ..||  .. ... .. .
lrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllelll

VDISRPPEEALVTVP
... ....  |..||
lslllvealllldvp

0039931 Phosphoglycerate mutase-like 252-456 8.5e-63 203.8 In-house 2-206 (219) alignment
Range on Protein: 252-456
Range on HMM: 2-206/219.0
IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR
.||.||||.| |..||. ||..|..|||| |. |.....|....   |..| ..|.|||||..|.|.|... |.|||.|..| .|.|||...|| |.|..
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN
 .|.|.||.|.|||..|.|.|..|...||...|||||..|..|.|.||||.|.   |....|..| ..|..|.. ..|...... |.    ...| .. .
lrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllllt

VDISR
... .
lelll

0053607 Phosphoglycerate mutase-like 249-433 4.8e-56 181.4 In-house 1-185 (191) alignment
Range on Protein: 249-433
Range on HMM: 1-185/191.0
PRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEF
.. .||.||||.| |..||. ||..|...||| |. ||... ....|  .|..| ..|..||||..|.|.|... |.|||.|..| .|.||....|| |.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVE
|.. .|.. ||.|.|||..|...|..|...|| ...||||..|..|.|.||||.|.   |.|..|..| ..|..|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv

0036777 Phosphoglycerate mutase-like 250-438 4.7e-54 175.8 In-house 3-230 (247) alignment
Range on Protein: 250-438
Range on HMM: 3-230/247.0
RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEI
. .||.||||.| |. ||. |  |..|...||| || |..........  .|..| ..|.|||||    |||   .|..... |.|.| |..| .|..||
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

QDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQL
.. || |.... .|.| ||.                         | |||..|.|.|..|...|| ..     |||||..|..|.|.||||.|.   |..
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

PYLKCPLHTVLKLTPVAYGCKVESIFLN
..|..| .....|.  ..| ..  ..||
lrlnlpngsitvleldddgklwvlesln

0037864 Phosphoglycerate mutase-like 243-434 5.1e-54 175.1 In-house 1-206 (211) alignment
Range on Protein: 243-434
Range on HMM: 1-206/211.0
MNIHVTPRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCE
|....... .||.||||.| |..||. |  |..|...||| |. |.... |....   |..| ..|.|||||..    |   .|.|... |.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

EMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAY
 .|.|||.. || |.. . .|.| .|.|.|||..|.|.|..|...|| ..     |||||..|..|.|.||||.|.   |.|..|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKVES
|....|
gwvlvs

0043909 Phosphoglycerate mutase-like 249-432 3.7e-53 172.8 In-house 2-228 (249) alignment
Range on Protein: 249-432
Range on HMM: 2-228/249.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.||||.| |..||. |  |..|...||| |. |........|.  .|..| .||.|||||    .||   .|.|... |.|.| |..| .|..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQDNYPLEFALRDQ-----------------------------DKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDK
| . || |.... .                             |.. .|.|.|||..|.|.|..|...|| ..     .|||...|..|.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

AAEQLPYLKCPLHTVLKLTPVAYGCKV
  |....|..| .....|.. ..|..|
sledilrlnlpngsitvlelddggkpv

0051064 Phosphoglycerate mutase-like 249-439 8.9e-53 171.9 In-house 3-232 (241) alignment
Range on Protein: 249-439
Range on HMM: 3-232/241.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.|||||| |. ||. |  |..|...||| |. |.....|..||  .|..| ..|.|||||    |||   .|..... |.||| |..| .|.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQ
|.. .| |......|.. .|.                         | |||..|...|..|.. || ..     .||||..|..|.|.||||.|.   |.
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLKCPLHTVLKLTPVAYGCKVESIFLNV
|..|..| ..|..|.  ..|..|  ..|| 
llrlnlpngsvtvleldddgkrvvlvllnd

0049178 Phosphoglycerate mutase-like 249-433 7.3e-52 168.7 In-house 3-224 (243) alignment
Range on Protein: 249-433
Range on HMM: 3-224/243.0
PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCEEMTYEE
.. .||.||||.| |..||. |  |..|...||| |. |.........|   |..| .||.|||||..    |   .|..... |.|.| |..| .|..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQDNYPLEFALRDQDKYRYRY-----------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLP
|...|| |.... .|.| .|.                       | |||..|...|..|...|| ..     ..|||..|..|.|.|||..|.   |.|.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVLKLTPVAYGCKVE
.|..| ..|..|.   .|....
rlnlpngsvtvlelddggwvlv

0048955 Phosphoglycerate mutase-like 252-428 2.4e-51 167.2 In-house 3-218 (240) alignment
Range on Protein: 252-428
Range on HMM: 3-218/240.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEIQD
.||.|||||| |..||. |  |..|...||| |. |.....|..||  .|..| ..|.|||||    |||   .|....  |.|.| |..| .|..||..
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

NYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELE-----RQENVLVICHQAVMRCLLAYFLDKAAEQLPY
..| |..|. .|.. .|.                         | |||..|...|..... ||      ...||||..|..|.|.||||.|.   |....
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr

LKCPLHTVLKLTPVAY
|..| . |..|.   .
lnipngsvtvlelddg

0036887 Phosphoglycerate mutase-like 250-434 3.1e-51 166.1 In-house 2-194 (202) alignment
Range on Protein: 250-434
Range on HMM: 2-194/202.0
RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISdqNIKDLKVWTSQMKRTIQTAEAL----GVPYEQWKVLNEIDAGVCEEMTYEEIQDN
. .||.||||.| |..||. |  |..|...||| |. |.....  ...   |..| ..|.|||||..    |.|..... |.||| |..| .|.|||.. 
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ---ENVLVICHQAVMRCLLAYFLDKAAEQLPYLK-CPLHTVLKLTPVAYGCKVES
|| |.| . .|.| .|.|.|||..|.|.|......|| ..   .||||..|..|.|.||||.|.   |.|..|. .| ..|..|.  ..|.....
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl

0050036 Phosphoglycerate mutase-like 252-423 7.1e-44 141.3 In-house 3-165 (171) alignment
Range on Protein: 252-423
Range on HMM: 3-165/171.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFIsdqniKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLefa
.||.||||.| ||.||. |  |..|...||. |. |....     .   |..| ..|..||||....|..... |.|.| |..| .|..||.. ||    
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype...

lRDQDKYRYRYPKGESYEDLVQRLEPVIMELErqENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKL
 ...|......| |||..|...|. |.. ||   .||||..|..|.|.|||..|.  .|....|..| ..|| |
.wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl

His_Phos_1 Histidine phosphatase superfamily (branch 1) 252-398 5.4e-39 126.6 Pfam-A 2-158 (158) alignment
Range on Protein: 252-398
Range on HMM: 2-158/158.0
IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP
.||.||||||.| .||. |.    |...||| |..|.. .......  .|.||..||.|||||.|     .|... . |.|.|.|..|....||.....|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
 |.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

His_Phos_1 Histidine phosphatase superfamily (branch 1) 252-398 5.4e-39 126.6 In-house 2-158 (158) alignment
Range on Protein: 252-398
Range on HMM: 2-158/158.0
IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP
.||.||||||.| .||. |.    |...||| |..|.. .......  .|.||..||.|||||.|     .|... . |.|.|.|..|....||.....|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
 |.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

subfamily_TIGAR_pd Subfamily TIGAR 251-404 6.8e-12 37.5 In-house 2-175 (222) alignment
Range on Protein: 251-404
Range on HMM: 2-175/222.0
SIYLCRHGESELNLKGRIGGD--PGLSPRGREFAKSLAQFISDQNIKdlKVWTSQMKRTIQTAEALG--------VPYEQWKVLNEIDAGVCEEMTYEEI
.... ||||.| | .. . |     ||..|.| ||..|...|...|.   . .|  .|. ||||.           . |. | | | . || | ....|.
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

QDNYpleFALRdqDKYRYRYPKGESYEDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVMRCLLAYFLD
..     .| .  .  .   . ||| | | .|| . . ||     ...             .|||..|....| ||.... 
rell...kaag..nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhv

subfamily_PGAM_pd Subfamily PGAM 252-333 8.3e-12 36.9 In-house 3-93 (248) alignment
Range on Protein: 252-333
Range on HMM: 3-93/248.0
IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL-------GVPYEQWKVLNEIDAGVCE
. | |||||||| . .. |  |  ||..|.| || ... . ..|..  .|.||..||..||.|..        .| |.   |||   |. .
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGalt

AAA_33 AAA domain 41-196 1.3e-11 35.0 Pfam-A 1-141 (143) alignment
Range on Protein: 41-196
Range on HMM: 1-141/143.0
LIVMVGLPARGKTYISKKLTRYLNWIGVPTREfnvgqYRRDVVKtyksfefF-----LpdneEGLKIRKQCALAALRDVRRFLsEEGGHvAVFDATNTTR
|...||||. ||.. ...| . | .. . . .     .|| . .                  .  . .|..  . .. .|. | ..|.. ...||||..|
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg.......tdqqslt....dytrvlkrlyqilnklarkal.sagrs.vivdatnlsr

ERRATIFNFGEQNGYKTFFVeSICVDPEVIAANIVQVKLGSPDYVNrDSDEATEDFMRRIE
|.|| . .. .. |..   |  . |..|..|... . .  . | ..   .|| ... .|.|
eerarfvklakrlgvpvriv.ylevpeetlaeRlakRerngddrse.vpeealdrmlarfe

subfamily_STS_pd Subfamily STS 270-398 3e-10 31.9 In-house 51-193 (245) alignment
Range on Protein: 270-398
Range on HMM: 51-193/245.0
GDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEqWKVLNEIDAGVCEEMTYEEIQ------DNYPLEFALRDQDKYR-----Y
 || |. ||   || |.. .....||   .. | . |.||||.|.    .  |.  ... |..| . ... .       .   .| .. . .|.     .
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls

RYPKGESYEDLVQRLEPVIMEL----ERQENVLVICHQAVMRCL
.  ..||.|.|..| . |. |.    ....|.|.. | | .  |
elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal

subfamily_TFC7_pd Subfamily TFC7 252-403 2.1e-09 28.4 In-house 3-178 (255) alignment
Range on Protein: 252-403
Range on HMM: 3-178/255.0
IYLCRHGESELN---------LKGrIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTA----EALGVPYEQWK-VLNEID----AGVCE
||..|||  .           |.| |  |. || || | || ||....  ..|   . .| ..| ..|.    |.| .|    . | . .       . |
iyiarhGyrsnwlpkgpypdpltg.idsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile

EMTYEEIQDNYPLEFAlRDQDKYRYRYPKGESYEDLVQRLE---PV-----IMELERQENVLVICHQAVMRCLLAYFL
 ...|...  .|     .| .      .|||. |.| .|..   ||     . . . .| .|.. | | .  |   .|
PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll

0053031 Phosphoglycerate mutase-like 252-385 2.6e-08 26.7 In-house 7-164 (342) alignment
Range on Protein: 252-385
Range on HMM: 7-164/342.0
IYLCRHG----ESELNLKGRI-----GGDPGLSPRGREFAKSLAQFISDQ---------NIKDLKVWTSQMKRTIQTAEALGV---PYEQWKVLNEIDAG
|.| |||    .| ..|  ..      |.. |.|.||| |. | ... .          | ....|..| . ||.|.|.|.     | | ...|| .   
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgw

VCEEMTYEEIQDNYPL---EFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQEN
.  .. .|.   .. |          ||.. .....| ...| .|..... .| .  .
qpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglg

Prefoldin Prefoldin subunit 148-211 1.2e-07 17.8 Pfam-A 37-102 (120) alignment
Range on Protein: 148-211
Range on HMM: 37-102/120.0
NGYKTFF--VESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDR
.|.....   ... |  ||.  . | |.||.  || ....||.| . ...| .|.. |.| |.|. 
egkevlvplgaglyvkaevkdtdkvlvdlGagyyveksleeAiellkkkleelekqlekleeelek

0047369 Phosphoglycerate mutase-like 252-342 3.3e-07 22.9 In-house 48-175 (438) alignment
Range on Protein: 252-342
Range on HMM: 48-175/438.0
IYLCRHGES-----------------------------ELNLKGRIGGDPGLSPRGREFAKSLAQFISDQ----NIKDL-KVWTSQMKRTIQTAEALGV-
..| |||.                               ||    . | . |.|.||| |. | ... .     | .|. .|..| . ||.|.|.|.   
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqaflaG

--PYEQWKVLNEIDAGVCEEMTYEEIQD
  | | ...|..|   .    |  | .|
lfppegtgelapilwqpipihtipesdd

0049059 Phosphoglycerate mutase-like 252-315 4.7e-07 22.2 In-house 47-144 (435) alignment
Range on Protein: 252-315
Range on HMM: 47-144/435.0
IYLCRHGE-----------------------------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD-----QNIKDLKVWTSQMKRTIQTAEALG
..| |||.                             |.||    . |.. |.|.||| |. |.... .      | ....|..| . ||.|.|.|. 
qvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl

KTI12 Chromatin associated protein KTI12 41-160 1.1e-06 18.0 Pfam-A 3-108 (270) alignment
Range on Protein: 41-160
Range on HMM: 3-108/270.0
LIVMVGLPARGKTYISKKLTRYLNWigvptREFNVGQYRRDVVKtYKSFEFFLPDNEEglKIRKQcalaALRDVRRFLSEEggHVAVFDATNTTRERRAT
|.|. |||. ||. ..|.| ..|.      .. .|   . . ..  .. ..    .|.  ..|..      ..|.| ||.|  .| . |..| ..  |  
LvvltGlPssGKstvakeLakalee.....egrsvvvisdeslg.iekdsykdskkek..alRss....lrsavkrdLske..kvVIvDslnYikgfRye

IFNFGEQNGYKTFFVESICV
...   .   .   |. .. 
Lyclakeakttlcvvyvvap

0048439 Phosphoglycerate mutase-like 252-373 2.2e-06 20.4 In-house 13-169 (391) alignment
Range on Protein: 252-373
Range on HMM: 13-169/391.0
IYLCRHG------------ESELNLKGRI--GGDPGLSPRGREFAKSLAQFISD----------Q---NIKDLKVWTSQMKRTIQTAEALGV---PYEQW
..| |||            .  ||.  ..   |.. |.|.||| .  | ... .          .   | ....|..| . ||.|.|.|.     | ...
qvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgl

KVLNEIDAGVCEEMTYEEIQDNYPL-----EFALRDQDKYRYRYPKGESYEDLVQRL
.|.. |..   ... .. . . .||       . ...  . |  ...|.......|.
tvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrv

0046349 Phosphoglycerate mutase-like 252-330 4.5e-06 19.2 In-house 11-118 (409) alignment
Range on Protein: 252-330
Range on HMM: 11-118/409.0
IYLCRHGE----------SELNLKGRIGGD---PGLSPRGREFAKSLAQFISD-------------QNIKDLKVWTSQMKRTIQTAEALGV---PYEQWK
..| |||.           . ... .. |.   . |.|.||| |  | ... .              | ....|..| . ||.|.|.|.     | ....
qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplgge

VLNEIDAG
.   .. .
ivpllrqd

subfamily_PGAM5_pd Subfamily PGAM5 250-399 5.6e-06 17.6 In-house 2-142 (189) alignment
Range on Protein: 250-399
Range on HMM: 2-142/189.0
RSIYLCRHGESELNLKgriGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEiDAGVCEEMTyeeIQDNYPLEFA
| . | |||. .|. .     .  |...||. |. . . . . |.|  |. .| | |...||. .    .. ..  .  . ..|      |. . . .  
rhlilvrhgqyvlddd...sdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk.tellreGaP...ikpePavkhw

LRDQDKYRYRYPKGE-SYEDLVQRLEPvimELERQENVLVICHQAVMRCLL
  .. ..    .. | ..  .. | .|   | ...   |..||  |.| |.
kpealqfyedgarieaafrkyfhrasp...eqkedsyelivchanvirylv

AAA_17 AAA domain 42-100 7.8e-06 17.3 Pfam-A 2-58 (121) alignment
Range on Protein: 42-100
Range on HMM: 2-58/121.0
IVMVGLPARGKTYISKKLTRYLNWIGvptreFNVGQ--YRRDVVKTYKSF-EFFLPDNEEGL
|. .| |. ||....|.| ..|...      .. ..  ..... .. . . |..  |...  
iaitGppGsGKsTlakeLaerlglpv.....lslddllreeglkelddgereskdadadlla

subfamily_PGAM_pd Subfamily PGAM 354-403 8.3e-06 17.3 In-house 141-195 (248) alignment
Range on Protein: 354-403
Range on HMM: 141-195/248.0
DKYRYRYPKGESYEDLVQRLEPVIME-----LERQENVLVICHQAVMRCLLAYFL
.. . ..|. || ...|.||.||. |     ......||.. |  ..|.|| .  
elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvle

0049226 Phosphoglycerate mutase-like 252-316 9.3e-06 18.2 In-house 7-89 (342) alignment
Range on Protein: 252-316
Range on HMM: 7-89/342.0
IYLCRHGE---------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD---------QNIKDLKVWTSQMKRTIQTAEALGV
..| |||.         ..|| .    |.. |.|.||| |  |.... .          | ....|..| . ||.|.|.|.  
qvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqafla