PFKFB4, Gene Page

Gene PFKFB4 in Homo sapiens

Synonym: PFKFB4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level	Class	Gene list	Wiki page
Fold	HP
Superfamily	HP
Family	HP1
Subfamily	PFKFB

Protein sequence

ID	Type	Fasta	BLAST phosphatome	Note
HsapP149_AA	protein	Get	Run
HsapP149_AA_242-466	phosphatase_domain	Get	Run

Domains

Summary

Details

Domain	Domain Description	Range	Significance	Score	Source	Profile Range (length)	Alignment
6PF2K	6-phosphofructo-2-kinase	35-249	2.1e-105	341.0	Pfam-A	9-223 (223)	alignment
Range on Protein: 35-249 Range on HMM: 9-223/223.0 MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTT ..\|....\|\|.\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|.\|.\|\|.\|. \|\|\|\|.\|\|\|..\|\|.....\|\|\| \|\|\|\|\|.\|\|.\|...\|\|\|\|\|.\|....\|.\|\|.\|.\|\|.\|\|\|\|\|\|\| lknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtNtt RERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHI \|\|\|\|..\|..\| \|.\|..\|..\|.\|\|.\| \|.\|.\|..\|\| .\|\|\|.\|\|\|\| .....\|\|..\|\|..\|.\|.\|\|..\|\|.\|\|.. \|..\|\|\|\|\|..\|\|\|.\|.\|\|\|.\|.... rerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqgyl QSRIVYYLMNIHVTP \|\|\|\|\|\|\|\|.\|\|\|..\| qsrivyyllNihlkp
subfamily_PFKFB_pd	Subfamily PFKFB	244-439	2.9e-103	335.5	In-house	1-197 (198)	alignment
Range on Protein: 244-439 Range on HMM: 1-197/198.0 NIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDN \|\|\|..\|\|.\|\|\|.\|\|\|\|\|\| \| \|\|\|\|\|\|\| \|..\|\|.\|.\|\|.\|\|.\|\|...\|.\|.\|.\|\|\|\|..\|\|\|\|\|\|\|\|.\|\|.\|.\|\|\|\|.\|.\|.\|\|\|.\|...\|\|\|\|\|... nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELER-QENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNV .\| \|\|. \|..\|\|\|\|\|\|\|\|.\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|.\|\|\|\| \|\|\|\|\|.\|.\|\|\|\|.\|.\|\|\|\|.\|\|\| \|\|.\|\|\|\|\|.\|\|\|\|\|.\|\|\|\|\|\|\|\|\|\|\|\|.. \|.\| fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
0035570	Phosphoglycerate mutase-like	252-466	1.9e-64	209.2	In-house	2-216 (219)	alignment
Range on Protein: 252-466 Range on HMM: 2-216/219.0 IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR .\|\|.\|\|\|\|.\| \|\|.\|\|. \|\|..\|..\|\|\|\| \|. \|.....\|..\|. .\|..\| ..\|.\|\|\|\|\|..\|.\|.\|... \|.\|\|\|.\|..\| .\|..\|\|.. \|\| \|.\|.. lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaaw DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN .\|.\|.\|\|.\|.\|\|\|..\|.\|.\|..\|...\|\|\|..\|\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. .\|....\|..\| ..\|..\|.. ..\|.\|.. ..\|\| .. ... .. . lrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllelll VDISRPPEEALVTVP ... .... \|..\|\| lslllvealllldvp
0039931	Phosphoglycerate mutase-like	252-456	8.5e-63	203.8	In-house	2-206 (219)	alignment
Range on Protein: 252-456 Range on HMM: 2-206/219.0 IYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALR .\|\|.\|\|\|\|.\| \|..\|\|. \|\|..\|..\|\|\|\| \|. \|.....\|.... \|..\| ..\|.\|\|\|\|\|..\|.\|.\|... \|.\|\|\|.\|..\| .\|.\|\|\|...\|\| \|.\|.. lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaaw DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQN .\|.\|.\|\|.\|.\|\|\|..\|.\|.\|..\|...\|\|...\|\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|....\|..\| ..\|..\|.. ..\|...... \|. ...\| .. . lrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllllt VDISR ... . lelll
0053607	Phosphoglycerate mutase-like	249-433	4.8e-56	181.4	In-house	1-185 (191)	alignment
Range on Protein: 249-433 Range on HMM: 1-185/191.0 PRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEF .. .\|\|.\|\|\|\|.\| \|..\|\|. \|\|..\|...\|\|\| \|. \|\|... ....\| .\|..\| ..\|..\|\|\|\|..\|.\|.\|... \|.\|\|\|.\|..\| .\|.\|\|....\|\| \|. mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel ALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVE \|.. .\|.. \|\|.\|.\|\|\|..\|...\|..\|...\|\| ...\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|.\|..\|..\| ..\|..\|.. .\|.... aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0036777	Phosphoglycerate mutase-like	250-438	4.7e-54	175.8	In-house	3-230 (247)	alignment
Range on Protein: 250-438 Range on HMM: 3-230/247.0 RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEI . .\|\|.\|\|\|\|.\| \|. \|\|. \| \|..\|...\|\|\| \|\| \|.......... .\|..\| ..\|.\|\|\|\|\| \|\|\| .\|..... \|.\|.\| \|..\| .\|..\|\| krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei QDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQL .. \|\| \|.... .\|.\| \|\|. \| \|\|\|..\|.\|.\|..\|...\|\| .. \|\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|.. aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi PYLKCPLHTVLKLTPVAYGCKVESIFLN ..\|..\| .....\|. ..\| .. ..\|\| lrlnlpngsitvleldddgklwvlesln
0037864	Phosphoglycerate mutase-like	243-434	5.1e-54	175.1	In-house	1-206 (211)	alignment
Range on Protein: 243-434 Range on HMM: 1-206/211.0 MNIHVTPRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCE \|....... .\|\|.\|\|\|\|.\| \|..\|\|. \| \|..\|...\|\|\| \|. \|.... \|.... \|..\| ..\|.\|\|\|\|\|.. \| .\|.\|... \|.\|.\| \|..\| MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale EMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAY .\|.\|\|\|.. \|\| \|.. . .\|.\| .\|.\|.\|\|\|..\|.\|.\|..\|...\|\| .. \|\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|.\|..\|..\| ..\|..\|. . gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg GCKVES \|....\| gwvlvs
0043909	Phosphoglycerate mutase-like	249-432	3.7e-53	172.8	In-house	2-228 (249)	alignment
Range on Protein: 249-432 Range on HMM: 2-228/249.0 PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE .. .\|\|.\|\|\|\|.\| \|..\|\|. \| \|..\|...\|\|\| \|. \|........\|. .\|..\| .\|\|.\|\|\|\|\| .\|\| .\|.\|... \|.\|.\| \|..\| .\|..\| mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae IQDNYPLEFALRDQ-----------------------------DKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDK \| . \|\| \|.... . \|.. .\|.\|.\|\|\|..\|.\|.\|..\|...\|\| .. .\|\|\|...\|..\|.\|.\|\|\|\|.\|. iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl AAEQLPYLKCPLHTVLKLTPVAYGCKV \|....\|..\| .....\|.. ..\|..\| sledilrlnlpngsitvlelddggkpv
0051064	Phosphoglycerate mutase-like	249-439	8.9e-53	171.9	In-house	3-232 (241)	alignment
Range on Protein: 249-439 Range on HMM: 3-232/241.0 PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEE .. .\|\|.\|\|\|\|\|\| \|. \|\|. \| \|..\|...\|\|\| \|. \|.....\|..\|\| .\|..\| ..\|.\|\|\|\|\| \|\|\| .\|..... \|.\|\|\| \|..\| .\|.\|\| mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee IQDNYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQ \|.. .\| \|......\|.. .\|. \| \|\|\|..\|...\|..\|.. \|\| .. .\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|. iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee LPYLKCPLHTVLKLTPVAYGCKVESIFLNV \|..\|..\| ..\|..\|. ..\|..\| ..\|\| llrlnlpngsvtvleldddgkrvvlvllnd
0049178	Phosphoglycerate mutase-like	249-433	7.3e-52	168.7	In-house	3-224 (243)	alignment
Range on Protein: 249-433 Range on HMM: 3-224/243.0 PRSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL----G---VPYEQWKVLNEIDAGVCEEMTYEE .. .\|\|.\|\|\|\|.\| \|..\|\|. \| \|..\|...\|\|\| \|. \|.........\| \|..\| .\|\|.\|\|\|\|\|.. \| .\|..... \|.\|.\| \|..\| .\|..\| mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae IQDNYPLEFALRDQDKYRYRY-----------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKAAEQLP \|...\|\| \|.... .\|.\| .\|. \| \|\|\|..\|...\|..\|...\|\| .. ..\|\|\|..\|..\|.\|.\|\|\|..\|. \|.\|. iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell YLKCPLHTVLKLTPVAYGCKVE .\|..\| ..\|..\|. .\|.... rlnlpngsvtvlelddggwvlv
0048955	Phosphoglycerate mutase-like	252-428	2.4e-51	167.2	In-house	3-218 (240)	alignment
Range on Protein: 252-428 Range on HMM: 3-218/240.0 IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAE----ALG---VPYEQWKVLNEIDAGVCEEMTYEEIQD .\|\|.\|\|\|\|\|\| \|..\|\|. \| \|..\|...\|\|\| \|. \|.....\|..\|\| .\|..\| ..\|.\|\|\|\|\| \|\|\| .\|.... \|.\|.\| \|..\| .\|..\|\|.. lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae NYPLEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELE-----RQENVLVICHQAVMRCLLAYFLDKAAEQLPY ..\| \|..\|. .\|.. .\|. \| \|\|\|..\|...\|..... \|\| ...\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|.... kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr LKCPLHTVLKLTPVAY \|..\| . \|..\|. . lnipngsvtvlelddg
0036887	Phosphoglycerate mutase-like	250-434	3.1e-51	166.1	In-house	2-194 (202)	alignment
Range on Protein: 250-434 Range on HMM: 2-194/202.0 RSIYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISdqNIKDLKVWTSQMKRTIQTAEAL----GVPYEQWKVLNEIDAGVCEEMTYEEIQDN . .\|\|.\|\|\|\|.\| \|..\|\|. \| \|..\|...\|\|\| \|. \|..... ... \|..\| ..\|.\|\|\|\|\|.. \|.\|..... \|.\|\|\| \|..\| .\|.\|\|\|.. trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek YPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ---ENVLVICHQAVMRCLLAYFLDKAAEQLPYLK-CPLHTVLKLTPVAYGCKVES \|\| \|.\| . .\|.\| .\|.\|.\|\|\|..\|.\|.\|......\|\| .. .\|\|\|\|..\|..\|.\|.\|\|\|\|.\|. \|.\|..\|. .\| ..\|..\|. ..\|..... ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
0050036	Phosphoglycerate mutase-like	252-423	7.1e-44	141.3	In-house	3-165 (171)	alignment
Range on Protein: 252-423 Range on HMM: 3-165/171.0 IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFIsdqniKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLefa .\|\|.\|\|\|\|.\| \|\|.\|\|. \| \|..\|...\|\|. \|. \|.... . \|..\| ..\|..\|\|\|\|....\|..... \|.\|.\| \|..\| .\|..\|\|.. \|\| lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype... lRDQDKYRYRYPKGESYEDLVQRLEPVIMELErqENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKL ...\|......\| \|\|\|..\|...\|. \|.. \|\| .\|\|\|\|..\|..\|.\|.\|\|\|..\|. .\|....\|..\| ..\|\| \| .wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1	Histidine phosphatase superfamily (branch 1)	252-398	5.4e-39	126.6	Pfam-A	2-158 (158)	alignment
Range on Protein: 252-398 Range on HMM: 2-158/158.0 IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP .\|\|.\|\|\|\|\|\|.\| .\|\|. \|. \|...\|\|\| \|..\|.. ....... .\|.\|\|..\|\|.\|\|\|\|\|.\| .\|... . \|.\|.\|.\|..\|....\|\|.....\| lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL \|.. ...\|\|...\|.\|.\|\|\|..\|...\|..\|...\|\| ..\|\|\|\|...\|..\|.\|.\| eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1	Histidine phosphatase superfamily (branch 1)	252-398	5.4e-39	126.6	In-house	2-158 (158)	alignment
Range on Protein: 252-398 Range on HMM: 2-158/158.0 IYLCRHGESELNLKGRIGGDPG--LSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALG----VPYEQWKVLNEIDAGVCEEMTYEEIQDNYP .\|\|.\|\|\|\|\|\|.\| .\|\|. \|. \|...\|\|\| \|..\|.. ....... .\|.\|\|..\|\|.\|\|\|\|\|.\| .\|... . \|.\|.\|.\|..\|....\|\|.....\| lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp LEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL \|.. ...\|\|...\|.\|.\|\|\|..\|...\|..\|...\|\| ..\|\|\|\|...\|..\|.\|.\| eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_TIGAR_pd	Subfamily TIGAR	251-404	6.8e-12	37.5	In-house	2-175 (222)	alignment
Range on Protein: 251-404 Range on HMM: 2-175/222.0 SIYLCRHGESELNLKGRIGGD--PGLSPRGREFAKSLAQFISDQNIKdlKVWTSQMKRTIQTAEALG--------VPYEQWKVLNEIDAGVCEEMTYEEI .... \|\|\|\|.\| \| .. . \| \|\|..\|.\| \|\|..\|...\|...\|. . .\| .\|. \|\|\|\|. . \|. \| \| \| . \|\| \| ....\|. ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel QDNYpleFALRdqDKYRYRYPKGESYEDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVMRCLLAYFLD .. .\| . . . . \|\|\| \| \| .\|\| . . \|\| ... .\|\|\|..\|....\| \|\|.... rell...kaag..nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhv
subfamily_PGAM_pd	Subfamily PGAM	252-333	8.3e-12	36.9	In-house	3-93 (248)	alignment
Range on Protein: 252-333 Range on HMM: 3-93/248.0 IYLCRHGESELNLKGRIGG--DPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEAL-------GVPYEQWKVLNEIDAGVCE . \| \|\|\|\|\|\|\|\| . .. \| \| \|\|..\|.\| \|\| ... . ..\|.. .\|.\|\|..\|\|..\|\|.\|.. .\| \|. \|\|\| \|. . lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGalt
AAA_33	AAA domain	41-196	1.3e-11	35.0	Pfam-A	1-141 (143)	alignment
Range on Protein: 41-196 Range on HMM: 1-141/143.0 LIVMVGLPARGKTYISKKLTRYLNWIGVPTREfnvgqYRRDVVKtyksfefF-----LpdneEGLKIRKQCALAALRDVRRFLsEEGGHvAVFDATNTTR \|...\|\|\|\|. \|\|.. ...\| . \| .. . . . .\|\| . . . . .\|.. . .. .\|. \| ..\|.. ...\|\|\|\|..\| lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg.......tdqqslt....dytrvlkrlyqilnklarkal.sagrs.vivdatnlsr ERRATIFNFGEQNGYKTFFVeSICVDPEVIAANIVQVKLGSPDYVNrDSDEATEDFMRRIE \|.\|\| . .. .. \|.. \| . \|..\|..\|... . . . \| .. .\|\| ... .\|.\| eerarfvklakrlgvpvriv.ylevpeetlaeRlakRerngddrse.vpeealdrmlarfe
subfamily_STS_pd	Subfamily STS	270-398	3e-10	31.9	In-house	51-193 (245)	alignment
Range on Protein: 270-398 Range on HMM: 51-193/245.0 GDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEqWKVLNEIDAGVCEEMTYEEIQ------DNYPLEFALRDQDKYR-----Y \|\| \|. \|\| \|\| \|.. .....\|\| .. \| . \|.\|\|\|\|.\|. . \|. ... \|..\| . ... . . .\| .. . .\|. . sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls RYPKGESYEDLVQRLEPVIMEL----ERQENVLVICHQAVMRCL . ..\|\|.\|.\|..\| . \|. \|. ....\|.\|.. \| \| . \| elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal
subfamily_TFC7_pd	Subfamily TFC7	252-403	2.1e-09	28.4	In-house	3-178 (255)	alignment
Range on Protein: 252-403 Range on HMM: 3-178/255.0 IYLCRHGESELN---------LKGrIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTA----EALGVPYEQWK-VLNEID----AGVCE \|\|..\|\|\| . \|.\| \| \|. \|\| \|\| \| \|\| \|\|.... ..\| . .\| ..\| ..\|. \|.\| .\| . \| . . . \| iyiarhGyrsnwlpkgpypdpltg.idsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile EMTYEEIQDNYPLEFAlRDQDKYRYRYPKGESYEDLVQRLE---PV-----IMELERQENVLVICHQAVMRCLLAYFL ...\|... .\| .\| . .\|\|\|. \|.\| .\|.. \|\| . . . .\| .\|.. \| \| . \| .\| PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll
0053031	Phosphoglycerate mutase-like	252-385	2.6e-08	26.7	In-house	7-164 (342)	alignment
Range on Protein: 252-385 Range on HMM: 7-164/342.0 IYLCRHG----ESELNLKGRI-----GGDPGLSPRGREFAKSLAQFISDQ---------NIKDLKVWTSQMKRTIQTAEALGV---PYEQWKVLNEIDAG \|.\| \|\|\| .\| ..\| .. \|.. \|.\|.\|\|\| \|. \| ... . \| ....\|..\| . \|\|.\|.\|.\|. \| \| ...\|\| . ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgw VCEEMTYEEIQDNYPL---EFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQEN . .. .\|. .. \| \|\|.. .....\| ...\| .\|..... .\| . . qpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglg
Prefoldin	Prefoldin subunit	148-211	1.2e-07	17.8	Pfam-A	37-102 (120)	alignment
Range on Protein: 148-211 Range on HMM: 37-102/120.0 NGYKTFF--VESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDR .\|..... ... \| \|\|. . \| \|.\|\|. \|\| ....\|\|.\| . ...\| .\|.. \|.\| \|.\|. egkevlvplgaglyvkaevkdtdkvlvdlGagyyveksleeAiellkkkleelekqlekleeelek
0047369	Phosphoglycerate mutase-like	252-342	3.3e-07	22.9	In-house	48-175 (438)	alignment
Range on Protein: 252-342 Range on HMM: 48-175/438.0 IYLCRHGES-----------------------------ELNLKGRIGGDPGLSPRGREFAKSLAQFISDQ----NIKDL-KVWTSQMKRTIQTAEALGV- ..\| \|\|\|. \|\| . \| . \|.\|.\|\|\| \|. \| ... . \| .\|. .\|..\| . \|\|.\|.\|.\|. qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqaflaG --PYEQWKVLNEIDAGVCEEMTYEEIQD \| \| ...\|..\| . \| \| .\| lfppegtgelapilwqpipihtipesdd
0049059	Phosphoglycerate mutase-like	252-315	4.7e-07	22.2	In-house	47-144 (435)	alignment
Range on Protein: 252-315 Range on HMM: 47-144/435.0 IYLCRHGE-----------------------------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD-----QNIKDLKVWTSQMKRTIQTAEALG ..\| \|\|\|. \|.\|\| . \|.. \|.\|.\|\|\| \|. \|.... . \| ....\|..\| . \|\|.\|.\|.\|. qvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl
KTI12	Chromatin associated protein KTI12	41-160	1.1e-06	18.0	Pfam-A	3-108 (270)	alignment
Range on Protein: 41-160 Range on HMM: 3-108/270.0 LIVMVGLPARGKTYISKKLTRYLNWigvptREFNVGQYRRDVVKtYKSFEFFLPDNEEglKIRKQcalaALRDVRRFLSEEggHVAVFDATNTTRERRAT \|.\|. \|\|\|. \|\|. ..\|.\| ..\|. .. .\| . . .. .. .. .\|. ..\|.. ..\|.\| \|\|.\| .\| . \|..\| .. \| LvvltGlPssGKstvakeLakalee.....egrsvvvisdeslg.iekdsykdskkek..alRss....lrsavkrdLske..kvVIvDslnYikgfRye IFNFGEQNGYKTFFVESICV ... . . \|. .. Lyclakeakttlcvvyvvap
0048439	Phosphoglycerate mutase-like	252-373	2.2e-06	20.4	In-house	13-169 (391)	alignment
Range on Protein: 252-373 Range on HMM: 13-169/391.0 IYLCRHG------------ESELNLKGRI--GGDPGLSPRGREFAKSLAQFISD----------Q---NIKDLKVWTSQMKRTIQTAEALGV---PYEQW ..\| \|\|\| . \|\|. .. \|.. \|.\|.\|\|\| . \| ... . . \| ....\|..\| . \|\|.\|.\|.\|. \| ... qvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgl KVLNEIDAGVCEEMTYEEIQDNYPL-----EFALRDQDKYRYRYPKGESYEDLVQRL .\|.. \|.. ... .. . . .\|\| . ... . \| ...\|.......\|. tvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrv
0046349	Phosphoglycerate mutase-like	252-330	4.5e-06	19.2	In-house	11-118 (409)	alignment
Range on Protein: 252-330 Range on HMM: 11-118/409.0 IYLCRHGE----------SELNLKGRIGGD---PGLSPRGREFAKSLAQFISD-------------QNIKDLKVWTSQMKRTIQTAEALGV---PYEQWK ..\| \|\|\|. . ... .. \|. . \|.\|.\|\|\| \| \| ... . \| ....\|..\| . \|\|.\|.\|.\|. \| .... qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplgge VLNEIDAG . .. . ivpllrqd
subfamily_PGAM5_pd	Subfamily PGAM5	250-399	5.6e-06	17.6	In-house	2-142 (189)	alignment
Range on Protein: 250-399 Range on HMM: 2-142/189.0 RSIYLCRHGESELNLKgriGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEiDAGVCEEMTyeeIQDNYPLEFA \| . \| \|\|\|. .\|. . . \|...\|\|. \|. . . . . \|.\| \|. .\| \| \|...\|\|. . .. .. . . ..\| \|. . . . rhlilvrhgqyvlddd...sdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk.tellreGaP...ikpePavkhw LRDQDKYRYRYPKGE-SYEDLVQRLEPvimELERQENVLVICHQAVMRCLL .. .. .. \| .. .. \| .\| \| ... \|..\|\| \|.\| \|. kpealqfyedgarieaafrkyfhrasp...eqkedsyelivchanvirylv
AAA_17	AAA domain	42-100	7.8e-06	17.3	Pfam-A	2-58 (121)	alignment
Range on Protein: 42-100 Range on HMM: 2-58/121.0 IVMVGLPARGKTYISKKLTRYLNWIGvptreFNVGQ--YRRDVVKTYKSF-EFFLPDNEEGL \|. .\| \|. \|\|....\|.\| ..\|... .. .. ..... .. . . \|.. \|... iaitGppGsGKsTlakeLaerlglpv.....lslddllreeglkelddgereskdadadlla
subfamily_PGAM_pd	Subfamily PGAM	354-403	8.3e-06	17.3	In-house	141-195 (248)	alignment
Range on Protein: 354-403 Range on HMM: 141-195/248.0 DKYRYRYPKGESYEDLVQRLEPVIME-----LERQENVLVICHQAVMRCLLAYFL .. . ..\|. \|\| ...\|.\|\|.\|\|. \| ......\|\|.. \| ..\|.\|\| . elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvle
0049226	Phosphoglycerate mutase-like	252-316	9.3e-06	18.2	In-house	7-89 (342)	alignment
Range on Protein: 252-316 Range on HMM: 7-89/342.0 IYLCRHGE---------SELNLKGRIGGDPGLSPRGREFAKSLAQFISD---------QNIKDLKVWTSQMKRTIQTAEALGV ..\| \|\|\|. ..\|\| . \|.. \|.\|.\|\|\| \| \|.... . \| ....\|..\| . \|\|.\|.\|.\|. qvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqafla

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