Gene PGAM1 in Homo sapiens

Synonym: HEL-S-35, PGAM-B, PGAMA, RP11-452K12.8, PGAM1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP151_AA protein Get Run
HsapP151_AA_0-250 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM_pd Subfamily PGAM 4-251 1.5e-124 406.2 In-house 1-248 (248) alignment 
Range on Protein: 4-251
Range on HMM: 1-248/248.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
.||||.|||||..| ||.|.||.||.||..|.||||. |.||..|..||||..|||.|||..||...|...||...||..||||||||||.||||||||.
iklvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaev

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEE
|.|.||..||||||||||.|||.| |......|.|||||..|.|..||..||||....|.||..||||...|||||||||.|||||.|...|.|||.|.|
akkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisde

AIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGK
||.||.||||||.|||||.||||.|..|||||||.|.||.||||.|||
aikeldlptgiplvyeldenlkpvkkkqflgDeesvkkaaeavanqgk
0043909 Phosphoglycerate mutase-like 4-242 2.8e-79 258.2 In-house 3-243 (249) alignment 
Range on Protein: 4-242
Range on HMM: 3-243/249.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||. ||.|.|| ||.|..|.. |.|.|.. |.||...|. ||....|  ||||.|.. .|.......|||....||.||..| |.||.|||.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYA--DLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLS
|.|..|..|...||||||.||..|...... ....| ..|  |.  |..| .|||.|..||.||...| . ...|.|..||| |||..|| ....| |||
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

EEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKA
 |.|..||||.|...|.|||...||.. ...|.| . ... 
ledilrlnlpngsitvlelddggkpvvvlvllndtshleal
0036777 Phosphoglycerate mutase-like 4-250 1.9e-77 252.3 In-house 3-246 (247) alignment 
Range on Protein: 4-250
Range on HMM: 3-246/247.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||. ||.|.|| ||.|..|.. |.|.||. |..|...|. ||....|  .|||.|.. .|.|.....||||...||.||.|| |.||.|||.
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEE
|.|..|..|..||..||..||..|......  .....|||.|. |.|| .|||.|..||.||...| . ...|.|..||. .||..|| ....|.||| |
aekypeelvawwrdpydyrppllelllell..lldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle

AIMELNLPTGIPIVYELDKNLKpIKPMQFLGDEETVRKAMEAVAAQG
.|..||||.|...|.|||.. | .  ...|.| . .....||||..|
dilrlnlpngsitvleldddgk.lwvleslndtshlelgleavadfg
0049178 Phosphoglycerate mutase-like 1-228 9.2e-72 233.7 In-house 1-224 (243) alignment 
Range on Protein: 1-228
Range on HMM: 1-224/243.0
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
|  ..|.|.||||. ||.|.|. ||.|..|.. |.|.|.. |..|...|. ||....|  ||||.|.. .|.|.....||||...||.||..| |.||.|
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk

AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNIskDRRYADLteDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGL
||.|||..|..|..||..||..||.......... .  ||..|||  |.||  |||.|..||.||...| . .....||.||. |||...| ....| ||
aeiaakypeelvawwrdpydarppalllldlllpll..drlladl..dllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllgl

SEEAIMELNLPTGIPIVYELDKNLKPIK
. |... ||||.| ..|.||| ..  ..
pleellrlnlpngsvtvlelddggwvlv
0051064 Phosphoglycerate mutase-like 1-230 2.2e-70 229.5 In-house 1-228 (241) alignment 
Range on Protein: 1-230
Range on HMM: 1-228/241.0
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
|. ..|.|.||||| ||.|.|. ||.|..|.. |.|.|.. |..|.|.|. ||....|  .|||.|.. ...|.....|||| ..||.|...| |.||..
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl

AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGL
.|.|.|..|..|...|...||.||..|......  .  |.|||.|..|.||  |||.|..||.||...| . .....||.||. .||...| ....| ||
eeiaekfpeelvawlrdpldvrppllelldlll..llldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllgl

SEEAIMELNLPTGIPIVYELDKNLKPIKPM
. |... ||||.| ..|.|||...|... .
pleellrlnlpngsvtvleldddgkrvvlv
0048955 Phosphoglycerate mutase-like 5-236 2.3e-70 229.3 In-house 2-231 (240) alignment 
Range on Protein: 5-236
Range on HMM: 2-231/240.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| ||.|.|. ||.|..|.. |.|.|.. |..|.|.|. ||....|  .|||.|.. ...|.....|||| ..||.||..| |.||...|.|
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

AKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|..|...|...||.||..|......  .. |.|||.|.||.||  |||.|..||.|....| . ...|.||.||. .||...| ....| ||. |.
ekfpeelvlwlrdpldvrppllelldell..llldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELDKNLKPIKPMQFLGDE
|..||.|.| ..|.|||..|.... ...|.|.
ilrlnipngsvtvlelddglvslndtshlddl
0037864 Phosphoglycerate mutase-like 3-231 6.2e-64 207.4 In-house 7-208 (211) alignment 
Range on Protein: 3-231
Range on HMM: 7-208/211.0
AYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAE
 ..|.|.||||. ||.|.|. ||.|..|.. |.|.|.. |.||.|.|..||....|  .|||.|.. .|.|.....|||....||.||..| | ||...|
mtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltlee

TAAKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpscESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSE
.|.|..|..|...|..||..||..                           |||.|..||.||...| . ...|.|..||. .||..|| ....| ||| 
iaekypeelvawlrdpydfrppgg...........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsl

EAIMELNLPTGIPIVYELDKNLKPIKPMQ
|....||||.| ..|.|||....... ..
eellrlnlpngsvtvlelddggwvlvsln
0035570 Phosphoglycerate mutase-like 5-224 3.8e-55 178.9 In-house 1-179 (219) alignment 
Range on Protein: 5-224
Range on HMM: 1-179/219.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||||.|. |  |..|.. |.|.|.. |.||.| |..||....|  .|||.|.. .       .|||....||.|...| | ||...|.|
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEivpqiKEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..|                           |  |||.|..||.||...|      ..|..||. .||...| ....| ||. |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELDKNL
|. ||||.| ..|.|||.. 
ilrlnlpngsvtvleldggg
0039931 Phosphoglycerate mutase-like 5-228 1.1e-53 174.1 In-house 1-183 (219) alignment 
Range on Protein: 5-228
Range on HMM: 1-183/219.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. |  |..|.. |.|.|.. |..|.| |..||....|  .|||.|.. .       .|||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEiVPqikeGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..|                           |  |||.|..||.||...|  ..    |..||. .||...| ....| ||| |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglslee

IMELNLPTGIPIVYELDKNLKPIK
|. ||||.| ..|.|||..   ..
ilrlnlpngsvtvlelddggwvlv
0036887 Phosphoglycerate mutase-like 5-225 4.3e-53 172.1 In-house 3-190 (202) alignment 
Range on Protein: 5-225
Range on HMM: 3-190/202.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRdaGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. |..|..|.. |.|.|.. |..|.  |. ||....|  .|||.|.. ...|..   |||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleeia

AKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpscESLKDTIARALPFWNEEIVPQikEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..||..                           |||.|..||.|....| . ..  .|..||. .||..|| ....| ||| |.
ekypeelaawlrdpydfrppgg...........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsled

IMELN-LPTGIPIVYELDKNLK
.. |. ||.| ..|.|||..  
llrlrklpngsvtvlelddggw
0050036 Phosphoglycerate mutase-like 5-222 1.6e-51 166.1 In-house 2-169 (171) alignment 
Range on Protein: 5-222
Range on HMM: 2-169/171.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALrdagyEFDICFTSVQKRAIRTLWTVLdaidqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||||.|| ||.| .|.. |...|.. |..|     .||....| ..||..|.. .|       |||....||.||..| ..||...|.|
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia

AKHGEaqvkiwrrsydvppppmepdhpfysniskdrRYADLTEDQLPSCESLKDTIARALPFWNEEIvpqikegKRVLIAAHGNSLRGIVKHLEGLSEEA
||..|                               ...||  ...|  |||.|..||.||...| .       ..||..|||...| ....| ||| |.
akype...............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglslee

IMELNLPTGIPIVYELDK
|..|.||.|...|.|||.
ilrlelpngsvlvleldd
0053607 Phosphoglycerate mutase-like 5-225 1.5e-50 163.6 In-house 3-182 (191) alignment 
Range on Protein: 5-225
Range on HMM: 3-182/191.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. |  |..|.. |.|.|.. ...|.. |..||....|  .||..|.. .       .|||....||.|...| ..||...|.|
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEIVpqikeGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|...|..|                           |  |||.|..||.||...| .      |..||. |||...| ....| ||. |.
ekypeelaawlrdpldyrp...........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglplee

IMELNLPTGIPIVYELDKNLK
.. ||||.| ..|.|||..  
llrlnlpngsvtvlelddggw
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 8e-43 139.1 Pfam-A 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|..|| |. |.. |.|.|.. |..|..|. ..| ..||  |||| |.. .|. .|   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSCESLKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLR
....|.. |..|..... ||                             |||.|...|. ||..| |  . ..|..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 8e-43 139.1 In-house 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|..|| |. |.. |.|.|.. |..|..|. ..| ..||  |||| |.. .|. .|   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSCESLKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLR
....|.. |..|..... ||                             |||.|...|. ||..| |  . ..|..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
subfamily_TIGAR_pd Subfamily TIGAR 6-105 8.6e-17 53.5 In-house 3-101 (222) alignment 
Range on Protein: 6-105
Range on HMM: 3-101/222.0
LVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDagYEFDICFTSVQKRAIRTLWTVLDAIDQ-MWLPVVRTWRLNERHYGGLTGLNKAETA
|...||||. .| |. . |  |  ||. | | ||| .. | .   ...  |.| ..|| .|   .| |. .   ..|.|. || || || . | ...|  
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

A
.
e
subfamily_PFKFB_pd Subfamily PFKFB 3-115 7.6e-12 37.1 In-house 6-109 (198) alignment 
Range on Protein: 3-115
Range on HMM: 6-109/198.0
AYKLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGY-EFdICFTSVQKRAIRTLWTVlDAIDQMWLPvvrtwrLNERHYGGLTGLNKA
 ....| ||||| .| ..| .|  |..|.. |.| ||. .. ...  . |. . .||  ||.|.|  .. .. .. |        |.|.  | . ||.  
preiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkel.rvwtselkrtiqTaell.glpkeqwka......LdeldaGkcdgltye

ETAAKHGEAQVKIW
|.  |..|   .  
eikekfpeefkerk
subfamily_PGAM5_pd Subfamily PGAM5 5-77 3.8e-06 18.2 In-house 3-70 (189) alignment 
Range on Protein: 5-77
Range on HMM: 3-70/189.0
KLVLIRHGESAWNLENRfsgwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQM
.|.|.|||.   . ..      .  |.. | . |.. |. |.. ...|..  .|   ||. |   ..  ... 
hlilvrhgqyvldddsd.....kkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdv
0053031 Phosphoglycerate mutase-like 6-116 7.3e-06 18.7 In-house 7-106 (342) alignment 
Range on Protein: 6-116
Range on HMM: 7-106/342.0
LVLIRHG----ESAWNLENRFS---GWYDADLSPAGHEEAKRGGQALRDA---------GYEFDICFTSVQKRAIRTLWTVLDAI--DQMWL---PVVRt
 ||.|||    .| ..|. .     .. . .|.| | |.|.  |..||.           ..    ..| . |.. .   .| ..  .. .    | .. 
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg.

wrlnerhyggltglnkaetaakhgeaqvkiwR
                                
...............................w