Gene PGAM2 in Homo sapiens

Synonym: GSD10, PGAM-M, PGAMM, PGAM2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP152_AA protein Get Run
HsapP152_AA_0-250 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM_pd Subfamily PGAM 5-251 1.1e-124 406.6 In-house 2-248 (248) alignment 
Range on Protein: 5-251
Range on HMM: 2-248/248.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETA
.||..|||||..|.||.||||.||.|||||.||||. .||.|.|..||||.||||||||..||..||. .||...||..||||||||||.||||||||.|
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva

AKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|.|||.|||||||.|..|||..|...|...|.|.|||. ||. |||..||||....|.||..||||...||.||||||.|||||.|...|.|||.||.|
kkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdea

IMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGK
|.||.||||||.||||...|||.|..|||||||.|.||.||||.|||
ikeldlptgiplvyeldenlkpvkkkqflgDeesvkkaaeavanqgk
0043909 Phosphoglycerate mutase-like 4-242 2e-76 248.8 In-house 3-243 (249) alignment 
Range on Protein: 4-242
Range on HMM: 3-243/249.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAET
 ||..|||||..||.|.||.||.|..|.|.| |.|.. ..|.|.... ||..|.| |||||.|...||.. ....|||....||.||..| |.||.|||.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

AAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMS
|.|..||.|...|||.|..||...| ....  ...  ..|   .    .| .|||.|..||.||...| . ...| |..||| |||..|| ....| |.|
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

DQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKA
...|..||||.|...|.||....||.. ...|.| . ... 
ledilrlnlpngsitvlelddggkpvvvlvllndtshleal
0036777 Phosphoglycerate mutase-like 4-250 5.6e-76 247.5 In-house 3-246 (247) alignment 
Range on Protein: 4-250
Range on HMM: 3-246/247.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAET
 ||..|||||..||.|.||.||.|..|.|.| |.||. ....|.... ||..|.| |.|||.|...||.. ....||||...||.||.|| |.||.|||.
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

AAKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQ
|.|..||.|..||...|..||.... ....  ... .||| |.  .|| .|||.|..||.||...| . ...| |..||. .||..|| ....|.|.|..
aekypeelvawwrdpydyrppllelllell..lldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle

AIMELNLPTGIPIVYELNKELKpTKPMQFLGDEETVRKAMEAVAAQG
.|..||||.|...|.||... | .  ...|.| . .....||||..|
dilrlnlpngsitvleldddgk.lwvleslndtshlelgleavadfg
0049178 Phosphoglycerate mutase-like 1-224 2e-70 229.3 In-house 1-220 (243) alignment 
Range on Protein: 1-224
Range on HMM: 1-220/243.0
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNK
| . ||..|||||..||.|.|..||.|..|.|.| |.|.. ......... ||..|.| |||||.|...||.......||||...||.||..| |.||.|
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk

AETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSIskERRYAGLKPgeLPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGM
||.|||..||.|..||...|..||..   ..... .   |..|.| .  ||  |||.|..||.||...| . .....||.||. |||...| ....| |.
aeiaakypeelvawwrdpydarppalllldlllpll..drlladldl..lpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllgl

SDQAIMELNLPTGIPIVYELNKEL
...... ||||.| ..|.||. ..
pleellrlnlpngsvtvlelddgg
0051064 Phosphoglycerate mutase-like 1-228 2.3e-68 222.9 In-house 1-226 (241) alignment 
Range on Protein: 1-228
Range on HMM: 1-226/241.0
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNK
|.. ||..||||||.|| |.|..||.|..|.|.| |.|.. .....|. . ||..|.| |.|||.|...|... ....|||| ..||.|...| |.||..
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl

AETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGM
.|.|.|..||.|...|...|..||...  ....  .  ..|||||... ||  |||.|..||.||...| . .....||.||. .||...| ....| |.
eeiaekfpeelvawlrdpldvrppllelldlll..llldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllgl

SDQAIMELNLPTGIPIVYELNKELKPTK
...... ||||.| ..|.||....|. .
pleellrlnlpngsvtvleldddgkrvv
0048955 Phosphoglycerate mutase-like 5-236 3.7e-68 222.1 In-house 2-231 (240) alignment 
Range on Protein: 5-236
Range on HMM: 2-231/240.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETA
||..||||||.|| |.|..||.|..|.|.| |.|.. .....|. . ||..|.| |.|||.|...|... ....|||| ..||.||..| |.||...|.|
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

AKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.|...|...|..||...  ....  .. ..|||.|... ||  |||.|..||.|....| . ...|.||.||. .||...| ....| |.....
ekfpeelvlwlrdpldvrppllelldell..llldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELNKELKPTKPMQFLGDE
|..||.|.| ..|.||...|.. . ...|.|.
ilrlnipngsvtvlelddglvslndtshlddl
0037864 Phosphoglycerate mutase-like 2-228 1.6e-63 206.1 In-house 2-205 (211) alignment 
Range on Protein: 2-228
Range on HMM: 2-205/211.0
A----THRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTG
.    . ||..|||||..||.|.|..||.|..|.|.| |.|.. ..|..|....||..|.| |.|||.|...||.. ....|||....||.||..| | |
slnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgaleg

LNKAETAAKHGEEQVKIWRRSFDIPPPPMdekhpyynsiskerryaglkpgelptcESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHL
|...|.|.|..||.|...|...|..||..                           |||.|..||.||...| . ...| |..||. .||..|| ....|
ltleeiaekypeelvawlrdpydfrppgg...........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl

EGMSDQAIMELNLPTGIPIVYELNKELKPTK
 |.|......||||.| ..|.||...... .
lglsleellrlnlpngsvtvlelddggwvlv
0035570 Phosphoglycerate mutase-like 5-224 4.6e-55 178.6 In-house 1-179 (219) alignment 
Range on Protein: 5-224
Range on HMM: 1-179/219.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..|  |..|.|.| |.|.. ..|..| ...||..|.| |.|||.|...|       .|||....||.|...| | ||...|.|
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia

AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEivpqiKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..|                           |  |||.|..||.||...|      . |..||. .||...| ....| |.....
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELNKEL
|. ||||.| ..|.||... 
ilrlnlpngsvtvleldggg
0039931 Phosphoglycerate mutase-like 5-224 4.6e-54 175.3 In-house 1-179 (219) alignment 
Range on Protein: 5-224
Range on HMM: 1-179/219.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..|  |..|.|.| |.|.. ....|| ...||..|.| |.|||.|...|       .|||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEiVPqikaGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..|                           |  |||.|..||.||...|  ..    |..||. .||...| ....| |.|...
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglslee

IMELNLPTGIPIVYELNKEL
|. ||||.| ..|.||... 
ilrlnlpngsvtvlelddgg
0036887 Phosphoglycerate mutase-like 4-223 4.5e-53 172.1 In-house 2-188 (202) alignment 
Range on Protein: 4-223
Range on HMM: 2-188/202.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKdaKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAET
 ||..|||||..||.|.|..|..|..|.|.| |.|.. .....  .. ||..|.| |.|||.|...|... .   |||....||.|...| | ||...|.
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleei

AAKHGEEQVKIWRRSFDIPPPPMdekhpyynsiskerryaglkpgelptcESLKDTIARALPFWNEEIVPQikAGKRVLIAAHGNSLRGIVKHLEGMSDQ
|.|..||.....|...|..||..                           |||.|..||.|....| . ..  .|..||. .||..|| ....| |.|..
aekypeelaawlrdpydfrppgg...........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsle

AIMELN-LPTGIPIVYELNKE
... |. ||.| ..|.||...
dllrlrklpngsvtvlelddg
0050036 Phosphoglycerate mutase-like 5-222 1.5e-50 163.0 In-house 2-169 (171) alignment 
Range on Protein: 5-222
Range on HMM: 2-169/171.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIkdakmEFDICYTSVLKRAIRTLWAILdgtdqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.||.|| | .|.|.| ..|.. ....     .||..|.| |.||..|...||       |||....||.||..| ..||...|.|
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia

AKHGEeqvkiwrrsfdippppmdekhpyynsiskerRYAGLKPGELPTCESLKDTIARALPFWNEEIvpqikagKRVLIAAHGNSLRGIVKHLEGMSDQA
||..|                               ... |    .|  |||.|..||.||...| .       ..||..|||...| ....| |.|...
akype...............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglslee

IMELNLPTGIPIVYELNK
|..|.||.|...|.||..
ilrlelpngsvlvleldd
0053607 Phosphoglycerate mutase-like 5-223 2.3e-50 163.0 In-house 3-180 (191) alignment 
Range on Protein: 5-223
Range on HMM: 3-180/191.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..|  |..|.|.| |.|.. |.....  ..||..|.| |.||..|...|       .|||....||.|...| ..||...|.|
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela

AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEIVpqikaGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..|                           |  |||.|..||.||...| .      |..||. |||...| ....| |.....
ekypeelaawlrdpldyrp...........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglplee

IMELNLPTGIPIVYELNKE
.. ||||.| ..|.||...
llrlnlpngsvtvlelddg
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 2.1e-43 141.0 Pfam-A 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||| ||.|.|..|| |..|.||| |.|.. .|..|.|. ..| .||| ||||| |....|.. |   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEEQVKIWRRSFDIPPPpmdekhpyynsiskerryaglkpgelpTCESLKDTIARALPFWNEEIVpQIKAGKRVLIAAHGNSLR
....||. |..|..... ||                             |||.|...|. ||..| |  . . |..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 2.1e-43 141.0 In-house 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||| ||.|.|..|| |..|.||| |.|.. .|..|.|. ..| .||| ||||| |....|.. |   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEEQVKIWRRSFDIPPPpmdekhpyynsiskerryaglkpgelpTCESLKDTIARALPFWNEEIVpQIKAGKRVLIAAHGNSLR
....||. |..|..... ||                             |||.|...|. ||..| |  . . |..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
subfamily_TIGAR_pd Subfamily TIGAR 5-105 1.3e-19 62.8 In-house 2-101 (222) alignment 
Range on Protein: 5-105
Range on HMM: 2-101/222.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDakMEFDICYTSVLKRAIRTLWAILDGTD-QMWLPVVRTWRLNERHYGGLTGLNKAET
.|..|||||. .|.|. . |  |  ||||| | ||| || ...  ....  ..| |.|| .|  .||     .  ..|.|. || || || . | ...| 
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

AA
 .
re
subfamily_PFKFB_pd Subfamily PFKFB 4-113 1.1e-14 46.4 In-house 7-107 (198) alignment 
Range on Protein: 4-113
Range on HMM: 7-107/198.0
HRLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIlDGTDQMWLPvvrtwrLNERHYGGLTGLNKAET
. ...|||||| .|...|  |  |.||.|.|.| ||. || ||. ...  . .|| |||.|.|  .. .  .. |        |.|.  | . ||.  |.
reiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.glpkeqwka......LdeldaGkcdgltyeei

AAKHGEEQVK
  |..||  .
kekfpeefke
subfamily_Dicty-HP1-1_pd Subfamily Dicty-HP1-1 6-66 2.5e-07 20.7 In-house 3-66 (210) alignment 
Range on Protein: 6-66
Range on HMM: 3-66/210.0
LVMVRHGESTWNQE-NRF--CGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRT
. ..||||||.|.. | .     ||| |.|.| ..|.. .. ...   . ..  .| | ||. |
vyiirhgestfnkaynekvdpylfdarlteegkkqanelsenvekllqdvelvisspltraldt
subfamily_PGAM5_pd Subfamily PGAM5 3-72 3.3e-06 18.4 In-house 1-65 (189) alignment 
Range on Protein: 3-72
Range on HMM: 1-65/189.0
THRLVMVRHGESTWNQENRfcgwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILD
| .|..||||. . ....      .  |.|.| . |..  | .|. ...|.. ..| . ||. |   |. 
trhlilvrhgqyvldddsd.....kkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiisk