Gene PGAM4 in Homo sapiens

Synonym: PGAM-B, PGAM1, PGAM3, dJ1000K24.1, PGAM4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP153_AA protein Get Run
HsapP153_AA_0-249 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM_pd Subfamily PGAM 4-251 2.4e-120 392.4 In-house 1-248 (248) alignment 
Range on Protein: 4-251
Range on HMM: 1-248/248.0
YKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
.||||.|||||..| ||.|..|.||.||..|.||||. |.||..|..||||. |||.|| ..||...|...||...||..||||||||||.||||||||.
iklvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaev

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSEE
|.|.||..||||||||||.|||.| |......|.|||||..|.|..||..|| |....|.||..||||...|||||||||.|||||.... |..||.|.|
akkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisde

AIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVCKAIEAVAAQGK
||.||.||||||.|||||.||||.|..|||||||.| ||.||||.|||
aikeldlptgiplvyeldenlkpvkkkqflgDeesvkkaaeavanqgk
0043909 Phosphoglycerate mutase-like 4-237 6.2e-74 240.7 In-house 3-238 (249) alignment 
Range on Protein: 4-237
Range on HMM: 3-238/249.0
YKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||..||.|.||  |.|..|.. |.|.|.. |.||...|. ||....|  || |.|.. .|.......|||....||.||..| |.||.|||.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYA--DLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLS
|.|..|..|...||||||.||..|...... ....| ..|  |.  |..|  || .|..||.||...| . ...|.|..||| |||..|  ....  |||
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

EEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEE
 |.|..||||.|...|.|||...||.. ...|.| .
ledilrlnlpngsitvlelddggkpvvvlvllndts
0036777 Phosphoglycerate mutase-like 4-249 1e-71 233.6 In-house 3-245 (247) alignment 
Range on Protein: 4-249
Range on HMM: 3-245/247.0
YKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||..||.|.||  |.|..|.. |.|.||. |..|...|. ||....|  .| |.|.. .|.|.....||||...||.||.|| |.||.|||.
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSEE
|.|..|..|..||..||..||..|......  .....|||.|. |.||  || .|..||.||...| . ...|.|..||. .||..|  ......||| |
aekypeelvawwrdpydyrppllelllell..lldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle

AIMELNLPTGIPIVYELDKNLKpIKPMQFLGDEETVCKAIEAVAAQ
.|..||||.|...|.|||.. | .  ...|.| . . ...||||..
dilrlnlpngsitvleldddgk.lwvleslndtshlelgleavadf
0049178 Phosphoglycerate mutase-like 1-228 2.4e-67 219.2 In-house 1-224 (243) alignment 
Range on Protein: 1-228
Range on HMM: 1-224/243.0
MAAYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
|  ..|.|.||||..||.|.|.  |.|..|.. |.|.|.. |..|...|. ||....|  || |.|.. .|.|.....||||...||.||..| |.||.|
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk

AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNIskDRRYADLteDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGL
||.|||..|..|..||..||..||.......... .  ||..|||  |.||  || .|..||.||...| . .....||.||. |||...  ..... ||
aeiaakypeelvawwrdpydarppalllldlllpll..drlladl..dllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllgl

SEEAIMELNLPTGIPIVYELDKNLKPIK
. |... ||||.| ..|.||| ..  ..
pleellrlnlpngsvtvlelddggwvlv
0048955 Phosphoglycerate mutase-like 5-236 3.2e-65 212.5 In-house 2-231 (240) alignment 
Range on Protein: 5-236
Range on HMM: 2-231/240.0
KLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.|||||.||.|.|.  |.|..|.. |.|.|.. |..|.|.|. ||....|  .| |.|.. ...|.....|||| ..||.||..| |.||...|.|
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

AKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSEEA
.|..|..|...|...||.||..|......  .. |.|||.|.||.||  || .|..||.|....| . ...|.||.||. .||...  . ... ||. |.
ekfpeelvlwlrdpldvrppllelldell..llldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELDKNLKPIKPMQFLGDE
|..||.|.| ..|.|||..|.... ...|.|.
ilrlnipngsvtvlelddglvslndtshlddl
0051064 Phosphoglycerate mutase-like 1-229 3.6e-65 212.4 In-house 1-227 (241) alignment 
Range on Protein: 1-229
Range on HMM: 1-227/241.0
MAAYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
|. ..|.|.|||||.||.|.|.  |.|..|.. |.|.|.. |..|.|.|. ||....|  .| |.|.. ...|.....|||| ..||.|...| |.||..
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl

AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGL
.|.|.|..|..|...|...||.||..|......  .  |.|||.|..|.||  || .|..||.||...| . .....||.||. .||...  . ... ||
eeiaekfpeelvawlrdpldvrppllelldlll..llldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllgl

SEEAIMELNLPTGIPIVYELDKNLKPIKP
. |... ||||.| ..|.|||...|... 
pleellrlnlpngsvtvleldddgkrvvl
0037864 Phosphoglycerate mutase-like 3-231 2.8e-59 192.2 In-house 7-208 (211) alignment 
Range on Protein: 3-231
Range on HMM: 7-208/211.0
AYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAE
 ..|.|.||||..||.|.|.  |.|..|.. |.|.|.. |.||.|.|..||....|  .| |.|.. .|.|.....|||....||.||..| | ||...|
mtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltlee

TAAKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpsyESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSE
.|.|..|..|...|..||..||..                           || .|..||.||...| . ...|.|..||. .||..|  ..... ||| 
iaekypeelvawlrdpydfrppgg...........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsl

EAIMELNLPTGIPIVYELDKNLKPIKPMQ
|....||||.| ..|.|||....... ..
eellrlnlpngsvtvlelddggwvlvsln
0035570 Phosphoglycerate mutase-like 5-224 6.5e-51 165.1 In-house 1-179 (219) alignment 
Range on Protein: 5-224
Range on HMM: 1-179/219.0
KLVLIRHGESTWNLENRFSCwyDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||..||||.|.    |..|.. |.|.|.. |.||.| |..||....|  .| |.|.. .       .|||....||.|...| | ||...|.|
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSYESPKDTIARALPFWNEEivpqiKEGKRVLIAAHGNSLQGIAKHVEGLSEEA
.|..|......|..||..|                           |  || .|..||.||...|      ..|..||. .||.... ..... ||. |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglplee

IMELNLPTGIPIVYELDKNL
|. ||||.| ..|.|||.. 
ilrlnlpngsvtvleldggg
0039931 Phosphoglycerate mutase-like 5-228 2.3e-49 160.0 In-house 1-183 (219) alignment 
Range on Protein: 5-228
Range on HMM: 1-183/219.0
KLVLIRHGESTWNLENRFSCwyDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||..||.|.|.    |..|.. |.|.|.. |..|.| |..||....|  .| |.|.. .       .|||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSYESPKDTIARALPFWNEEiVPqikeGKRVLIAAHGNSLQGIAKHVEGLSEEA
.|..|......|..||..|                           |  || .|..||.||...|  ..    |..||. .||.... ..... ||| |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglslee

IMELNLPTGIPIVYELDKNLKPIK
|. ||||.| ..|.|||..   ..
ilrlnlpngsvtvlelddggwvlv
0036887 Phosphoglycerate mutase-like 5-225 1.6e-48 157.2 In-house 3-190 (202) alignment 
Range on Protein: 5-225
Range on HMM: 3-190/202.0
KLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRdaGYEFDICLTSVQKRVIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||..||.|.|.  ..|..|.. |.|.|.. |..|.  |. ||....|  .| |.|.. ...|..   |||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleeia

AKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpsyESPKDTIARALPFWNEEIVPQikEGKRVLIAAHGNSLQGIAKHVEGLSEEA
.|..|......|..||..||..                           || .|..||.|....| . ..  .|..||. .||..|  ..... ||| |.
ekypeelaawlrdpydfrppgg...........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsled

IMELN-LPTGIPIVYELDKNLK
.. |. ||.| ..|.|||..  
llrlrklpngsvtvlelddggw
0050036 Phosphoglycerate mutase-like 5-222 7.1e-47 151.0 In-house 2-169 (171) alignment 
Range on Protein: 5-222
Range on HMM: 2-169/171.0
KLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALrdagyEFDICLTSVQKRVIRTLWTVLdaidqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||..||||.||  |.| .|.. |...|.. |..|     .||....| ..| ..|.. .|       |||....||.||..| ..||...|.|
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia

AKHGEaqvkiwrrsydvppppmepdhpfysniskdrRYADLTEDQLPSYESPKDTIARALPFWNEEIvpqikegKRVLIAAHGNSLQGIAKHVEGLSEEA
||..|                               ...||  ...| .|| .|..||.||...| .       ..||..|||...  ..... ||| |.
akype...............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglslee

IMELNLPTGIPIVYELDK
|..|.||.|...|.|||.
ilrlelpngsvlvleldd
0053607 Phosphoglycerate mutase-like 5-225 1.4e-46 150.7 In-house 3-182 (191) alignment 
Range on Protein: 5-225
Range on HMM: 3-182/191.0
KLVLIRHGESTWNLENRFSCwyDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||..||.|.|.    |..|.. |.|.|.. ...|.. |..||....|  .| ..|.. .       .|||....||.|...| ..||...|.|
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela

AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSYESPKDTIARALPFWNEEIVpqikeGKRVLIAAHGNSLQGIAKHVEGLSEEA
.|..|......|...|..|                           |  || .|..||.||...| .      |..||. |||.... ..... ||. |.
ekypeelaawlrdpldyrp...........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglplee

IMELNLPTGIPIVYELDKNLK
.. ||||.| ..|.|||..  
llrlnlpngsvtvlelddggw
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 1.1e-38 125.6 Pfam-A 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|.. | |. |.. |.|.|.. |..|..|. ..| . ||  || | |.. .|. .|   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSYESPKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLQ
....|.. |..|..... ||                             || .|...|. ||..| |  . ..|..||| .||..|.
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-191 1.1e-38 125.6 In-house 1-156 (158) alignment 
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|.. | |. |.. |.|.|.. |..|..|. ..| . ||  || | |.. .|. .|   .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk

AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSYESPKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLQ
....|.. |..|..... ||                             || .|...|. ||..| |  . ..|..||| .||..|.
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
subfamily_TIGAR_pd Subfamily TIGAR 6-105 4.1e-14 44.8 In-house 3-101 (222) alignment 
Range on Protein: 6-105
Range on HMM: 3-101/222.0
LVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDagYEFDICLTSVQKRVIRTLWTVLDAIDQ-MWLPVVRTWRLNERHYGGLTGLNKAETA
|...||||. .| |. .    |  ||. | | ||| .. | .   ...  ..| ..|  .|   .| |. .   ..|.|. || || || . | ...|  
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

A
.
e
subfamily_PFKFB_pd Subfamily PFKFB 3-114 9.1e-10 30.3 In-house 6-108 (198) alignment 
Range on Protein: 3-114
Range on HMM: 6-108/198.0
AYKLVLIRHGESTWNLENRFSCwyDADLSPAGHEEAKRGGQALRDAGY-EFdICLTSVQKRVIRTLWTVlDAIDQMWLPvvrtwrLNERHYGGLTGLNKA
 ....| ||||| .| ..| .   |..|.. |.| ||. .. ...  . |. .  ||  || |.|  .. .. .. |        |.|.  | . ||.  
preiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkel.rvwtselkrtiqTaell.glpkeqwka......LdeldaGkcdgltye

ETAAKHGEAQVKI
|.  |..|   . 
eikekfpeefker
LysM LysM domain 187-218 2.2e-06 14.0 Pfam-A 6-28 (44) alignment 
Range on Protein: 187-218
Range on HMM: 6-28/44.0
GNSLQGIAKHVeGLSEEAIMELNlptgipivY
| .|  ||. . ||||....|||         
GDTLwkIAsry.glseqeltelN........e
0053031 Phosphoglycerate mutase-like 6-167 7.1e-06 18.7 In-house 7-156 (342) alignment 
Range on Protein: 6-167
Range on HMM: 7-156/342.0
LVLIRHG----ESTWNLENRFSCWYD---ADLSPAGHEEAKRGGQALRDA---------GYEFDICLTSVQKRVIRTLWTVLDAI--DQMWL---PVVRt
 ||.|||    .|...|. .    |.    .|.| | |.|.  |..||.           ..     .| . |.. .   .| ..  .. .    | .. 
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg.

wrlnerhyggltglnkaetaakhgeaqvkiwrrsydVPPPP-----MEPDHPFYSNISKdRRYADLTEDQLPSYESPKDTIARALPFW
                                      |.|       .|. .. | .  . ..|   .. ...|  |... |.|...
....................................wqpipihtepessdalllpnydp.cpafdkllkealaseevkellerylell