Gene PGAM5 in Homo sapiens

Synonym: BXLBV68, PGAM5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM5
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP154_AA protein Get Run
HsapP154_AA_95-284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM5_pd Subfamily PGAM5 97-285 2.1e-101 328.8 In-house 1-189 (189) alignment 
Range on Protein: 97-285
Range on HMM: 1-189/189.0
TRHIFLIRHSQYHVDGSLEKdRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVS-TDLLREGAPIEPDPPVSHWKPEAV
|||..|.||.||..|.. .| ..||.|||.|||||| ||..|.|||.|.|.|.|.||.||.||||..||.|.| . |.||||||||.|.|.|.||||||.
trhlilvrhgqyvldddsdk.kiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktktellreGaPikpePavkhwkpeal

QYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDK
|.||||||||||||.|.|||...|.|||||...||||||||.||||||.|||.||||||||||||.|.|||.|||.||.|||.||.|..|
qfyedgarieaafrkyfhraspeqkedsyelivchanvirylvcralqlPpeawlrlslnngsitklsirPsGrvslrelGdvgflPaek
0051064 Phosphoglycerate mutase-like 97-282 5.5e-34 110.5 In-house 3-237 (241) alignment 
Range on Protein: 97-282
Range on HMM: 3-237/241.0
TRHIFLIRHSQ--YHVDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLRE-------GAPIE-
.....|.|| .  ....| |    |. ||.||||||. .| |||.||.||.....| ..|||.| .|| ..|.   .  | .. |||       | ..| 
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

-----PDPPVSHWK--------------------------------PEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFP
     |.  | ..                                 | .  . .  ||...|.. ...|.     .... ....|..|||......|..|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll...ldgknvlvVsHggvirallayllglp

PEGWLRLSLNNGSITHLVIRPNG-RVALRTLGDTGFMP
.|..|||.|.|||.|.|.....| || |..|.||....
leellrlnlpngsvtvleldddgkrvvlvllndtshle
0036777 Phosphoglycerate mutase-like 97-283 1.1e-33 109.3 In-house 2-237 (247) alignment 
Range on Protein: 97-283
Range on HMM: 2-237/247.0
TRHIFLIRHSQYH--VDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREG------------
.....|.|| .    ..| .    |. ||.||||||...| .|..|||.|.... | ..|||.| .|| ..|.   .  | .. |||             
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

--------------APIEPDPPVSHWK-------------------PEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFP
               |. ..||....                    |..  . .  ||...|......|.     .... . ..|..|.|......|...
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll...kdgenvlvVsHggvlrallayllgls

PEGWLRLSLNNGSITHLVIRPNGR-VALRTLGDTGFMPP
.| .||| |.|||||.|.....|  . |..|.||.... 
ledilrlnlpngsitvleldddgklwvleslndtshlel
0043909 Phosphoglycerate mutase-like 97-284 2.3e-33 108.1 In-house 2-243 (249) alignment 
Range on Protein: 97-284
Range on HMM: 2-243/249.0
TRHIFLIRHSQYHV--DGSL--EKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLREG------------
.....|.|| .     .| .    |. ||.||||||...| .|..||..|.... | ..|||.|  || ..|.   .  . .. |||             
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

-------------------------------APIEPD------PPVSHWKPEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRA
                               . . .|       | ..  |..  . .  ||...|......|..    .... . ..|..|.|......
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll...kdggnvliVaHggvlrallayl

LQFPPEGWLRLSLNNGSITHLVIRPNGR--VALRTLGDTGFMPPD
|....| .|||.|.|||||.|.. ..|.  | |..|.||..... 
lglsledilrlnlpngsitvlelddggkpvvvlvllndtshleal
0035570 Phosphoglycerate mutase-like 100-282 4.6e-32 103.6 In-house 2-194 (219) alignment 
Range on Protein: 100-282
Range on HMM: 2-194/219.0
IFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIEPD
..|.|| . .  ..| |  |. ||..|||||. .| .||.||..| ....| ..|||.| .||     |.  . .. |||              |   |.
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.....glpveidprLrEidfgdlegltldeiaekype

PPVSHWKPEAVQYYEDG-------ARIEAAFRNYihradarqEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNG-RVALRTLG
  . ..   .  .. .|       ||...|.. .        |...  . ..|..|||......|..|.| .|||.|.|||.|.| ....| .. |..|.
elaawlrdpydyrppggEsladvvaRvlpaleel........edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvlln

DTGFMP
||....
dtshle
0039931 Phosphoglycerate mutase-like 99-283 8.8e-32 102.6 In-house 1-193 (219) alignment 
Range on Protein: 99-283
Range on HMM: 1-193/219.0
HIFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIEP
...|.|| . .  |.| |  |. ||..|||||. .| ||..|||.|  ...| ..|||.| .||     |.  . .. |||              |   |
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.....glpveidprLrEidfgdlegltleeiaekyp

DPPVSHWK-------PEAVQYYEDGARIEAAFRNYIHradarqeeDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPnGRVALRTLG
.  . ...       |..  . .  ||...|.. ...        ..  . ..|..|||......|....| .|||.|.|||.|.| ... |.. |..|.
eelaawlrdpydyrppggEsladvvaRvlpaleella........genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.ggwvlvlln

DTGFMPP
.|.....
ltshldd
0048955 Phosphoglycerate mutase-like 100-283 1.3e-31 102.7 In-house 3-230 (240) alignment 
Range on Protein: 100-283
Range on HMM: 3-230/240.0
IFLIRHSQYH--VDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLREG-------APIE----
..|.|| .    ..| |    |. ||.||||||. .| |||.||.|| ....| ..|||.| .|| ..|.   .  | .. |||         ...    
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

--PDPPVSHWK--------------------------------PEAVQYYEDGARIEAAFRNYIHRADArqeEDSYEIFICHANVIRYIVCRALQFPPEG
  |.  | ..                                 |..  . .  ||..||.. ...||     .... ....|..|||......|..|.| 
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk...pgknvlvVsHggvirallayllglplee

WLRLSLNNGSITHLVIRPNgrvaLRTLGDTGFMPP
.|||...|||.|.|.....    |..|.|| ....
ilrlnipngsvtvlelddg....lvslndtshldd
0037864 Phosphoglycerate mutase-like 96-277 1.4e-30 98.7 In-house 6-209 (211) alignment 
Range on Protein: 96-277
Range on HMM: 6-209/211.0
ATRHIFLIRHSQYHV--DGSLEK--DRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLL-------------R
......|.|| . .   .| |    |. ||.||||||...| .||.|||.|. ...| ..|||.| .|| ..|.   .  . .. |              
lmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltle

EGAPIEPDPPVSHWKPEAVQYYEDG-------ARIEAAFRNYIHRAdarQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPnGR
| |   |. .| ..   .  ....|       ||...|......|.   ...... . ..|..|.|......|....| .||| |.|||.|.| ... |.
eiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarl...lkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd.gg

VALRTLGD
. |..|..
wvlvslnl
0036887 Phosphoglycerate mutase-like 97-281 4.3e-29 93.9 In-house 1-201 (202) alignment 
Range on Protein: 97-281
Range on HMM: 1-201/202.0
TRHIFLIRHSQYH--VDGSLEK--DRTLTPLGREQAELTGLRLAslGLKFNKIVHSSMTRAIETTDIISRHLPgVCKVSTDLLRE-------------GA
.....|.|| . .  |.| |    |. ||.||||||. .| |||  ||.|  ...| ..|||.| .||...|. .  . .. |||              |
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg.lpvivdprlrEidfgalegltleeia

PIEPDPPVSHWKPEAVQYYEDG-------ARIEAAFRNYIHRAdarqeEDSYEIFICHANVIRYIVCRALQFPPEGWLRLS-LNNGSITHLVIrPNGRVA
   |.  . ..   .  .. .|       ||..||......|.     ...  ....|..|.|......|....| .|||  |.|||.|.| . ..|.. 
ekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl.....dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel.ddggwv

LRTLGDTGFM
|..|.||...
lvllndtshL
0049178 Phosphoglycerate mutase-like 97-281 3.4e-28 91.3 In-house 3-232 (243) alignment 
Range on Protein: 97-281
Range on HMM: 3-232/243.0
TRHIFLIRHSQ-----YHVDGSLeKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREGA----------
.....|.|| .     ...  .   |. ||.||||||...| .||.|||||. .. | ..|||.| .|| ..|.   .  | .. |||            
mtrlyLvRHGetewnaegrlqgw.tDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka

----------------PIEPDPPVSHW-----------------KPEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFPP
                | .  ||. ..                  |..  . .  ||...|........     ...  . ..| .|||......|. |.
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell...hdgktvlvVaHggvirallalllglpl

EGWLRLSLNNGSITHLVIRPnGRVALRTLGDTGFM
| .||| |.|||.|.| . . |.. |..|.||...
eellrlnlpngsvtvleldd.ggwvlvslndtshl
0053607 Phosphoglycerate mutase-like 98-270 3.7e-28 90.8 In-house 2-183 (191) alignment 
Range on Protein: 98-270
Range on HMM: 2-183/191.0
RHIFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIE
....|.|| . .  ..| |  |. ||.||||||.... .||.||||| ....| ..||..| .||     |.  . .. |||              |   
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.....glpvevdprlrEidfgdwegltleelaeky

PDPPV-------SHWKPEAVQYYEDGARIEAAFRNYIHradarqeeDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRV
|.  .        .. |..  ...  ||...|......        ..  . ..|..|||......|..|.| .|||.|.|||.|.| ....| |
peelaawlrdpldyrppggEsladvaaRvlpaleella........ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwv
0050036 Phosphoglycerate mutase-like 100-266 8.6e-20 63.2 In-house 3-169 (171) alignment 
Range on Protein: 100-266
Range on HMM: 3-169/171.0
IFLIRHSQYHVD--GSLE--KDRTLTPLGREQAELTGLRLaslglKFNKIVHSSMTRAIETTDIISrhlpgVCKVSTDLLRE----------------GA
..|.|| . . .  | .    |  ||.|||.||. .| .|     .|  ...| ..||..| ..|      .  . .. |||                  
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.....lpvivdprLrErdfGawegltldeiaaky

PIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIhradarqeedSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRP
|     .. .. |..  ...  ||. .|.....          .  . ..|..|||......|. ..| .||| |.|||...| . .
pewlldlldlappggEsladvlaRvlpaleell..........gnvlvvaHggvirallalllglsleeilrlelpngsvlvleldd
His_Phos_1 Histidine phosphatase superfamily (branch 1) 99-236 6.1e-17 55.0 Pfam-A 1-157 (158) alignment 
Range on Protein: 99-236
Range on HMM: 1-157/158.0
HIFLIRHSQ--YHVDGSLEKDRT--LTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP-------GVCKVSTD----LLREGAPIEP
...|.|| .  .. .|.|...    ||. |||||. .| .|.. .|...... | ..|||.|..|.. .|        .. ... .    | .| .. | 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

DPPVSHWKP--------EAVQYYEDGARIEAAFRNYIHradARQEEDSYeIFICHANVIRY
.  . .||         |. .. .  .|........|.   |......  . ..|..|.| 
peeyekwkrdkkefrppegesladvyeRvapfleelie...akdkgenv.livsHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 99-236 6.1e-17 55.0 In-house 1-157 (158) alignment 
Range on Protein: 99-236
Range on HMM: 1-157/158.0
HIFLIRHSQ--YHVDGSLEKDRT--LTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP-------GVCKVSTD----LLREGAPIEP
...|.|| .  .. .|.|...    ||. |||||. .| .|.. .|...... | ..|||.|..|.. .|        .. ... .    | .| .. | 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

DPPVSHWKP--------EAVQYYEDGARIEAAFRNYIHradARQEEDSYeIFICHANVIRY
.  . .||         |. .. .  .|........|.   |......  . ..|..|.| 
peeyekwkrdkkefrppegesladvyeRvapfleelie...akdkgenv.livsHggvlra
subfamily_STS_pd Subfamily STS 113-219 4.2e-08 24.9 In-house 48-153 (245) alignment 
Range on Protein: 113-219
Range on HMM: 48-153/245.0
SLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREGAPIEPDpPVSHWKPEAVQyyEDGARIEAAFRN
....|  ||  |  ||.|.| .| . |.| . |. | ..| |.|.  |   |      || . ||   .. .     . ..||...  . . .|.  .. 
dyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglgkkikikvepgllewlkldrkp.ipellspeelk..kffpqidedYkp

YIHRADARQ
 .   . ..
vlslselks
subfamily_TIGAR_pd Subfamily TIGAR 116-164 8.8e-08 24.1 In-house 23-69 (222) alignment 
Range on Protein: 116-164
Range on HMM: 23-69/222.0
KDRTLTPLGREQAELTGLRLAslGLKFNKIVHSSMTRAIETTDIISRHL
 |  |.. |.|||.... ||.    |.| |. |   || .|..|| ..|
tdtpLsekGveQakrvakrLs..nekinyifsSdllRAkqTaeiilkal
subfamily_PGAM_pd Subfamily PGAM 100-164 1.9e-07 22.6 In-house 3-71 (248) alignment 
Range on Protein: 100-164
Range on HMM: 3-71/248.0
IFLIRHSQYHVDGSL----EKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHL
..|.|| . ...        .|  |.. |.|.|. .|  | . .|.|.... | ..||..|...|  .|
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileel
0053031 Phosphoglycerate mutase-like 99-178 7.7e-06 18.6 In-house 6-105 (342) alignment 
Range on Protein: 99-178
Range on HMM: 6-105/342.0
HIFLIRHS----QYHVDGSLEKD-------RTLTPLGREQAELTGLRLASL---------GLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREG
 |.|.||     ... . .  ..         |||||||||  .| || ..           .  ..  |.. |....   . . | . .. . .  . |
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg