PGAM5, Gene Page

Gene PGAM5 in Homo sapiens

Synonym: BXLBV68, PGAM5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level	Class	Gene list	Wiki page
Fold	HP
Superfamily	HP
Family	HP1
Subfamily	PGAM5

Protein sequence

ID	Type	Fasta	BLAST phosphatome	Note
HsapP154_AA	protein	Get	Run
HsapP154_AA_95-284	phosphatase_domain	Get	Run

Domains

Summary

Details

Domain	Domain Description	Range	Significance	Score	Source	Profile Range (length)	Alignment
subfamily_PGAM5_pd	Subfamily PGAM5	97-285	2.1e-101	328.8	In-house	1-189 (189)	alignment
Range on Protein: 97-285 Range on HMM: 1-189/189.0 TRHIFLIRHSQYHVDGSLEKdRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVS-TDLLREGAPIEPDPPVSHWKPEAV \|\|\|..\|.\|\|.\|\|..\|.. .\| ..\|\|.\|\|\|.\|\|\|\|\|\| \|\|..\|.\|\|\|.\|.\|.\|.\|.\|\|.\|\|.\|\|\|\|..\|\|.\|.\| . \|.\|\|\|\|\|\|\|\|.\|.\|.\|.\|\|\|\|\|\|. trhlilvrhgqyvldddsdk.kiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktktellreGaPikpePavkhwkpeal QYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDK \|.\|\|\|\|\|\|\|\|\|\|\|\|.\|.\|\|\|...\|.\|\|\|\|\|...\|\|\|\|\|\|\|\|.\|\|\|\|\|\|.\|\|\|.\|\|\|\|\|\|\|\|\|\|\|\|.\|.\|\|\|.\|\|\|.\|\|.\|\|\|.\|\|.\|..\| qfyedgarieaafrkyfhraspeqkedsyelivchanvirylvcralqlPpeawlrlslnngsitklsirPsGrvslrelGdvgflPaek
0051064	Phosphoglycerate mutase-like	97-282	5.5e-34	110.5	In-house	3-237 (241)	alignment
Range on Protein: 97-282 Range on HMM: 3-237/241.0 TRHIFLIRHSQ--YHVDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLRE-------GAPIE- .....\|.\|\| . ....\| \| \|. \|\|.\|\|\|\|\|\|. .\| \|\|\|.\|\|.\|\|.....\| ..\|\|\|.\| .\|\| ..\|. . \| .. \|\|\| \| ..\| mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee -----PDPPVSHWK--------------------------------PEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFP \|. \| .. \| . . . \|\|...\|.. ...\|. .... ....\|..\|\|\|......\|..\| iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll...ldgknvlvVsHggvirallayllglp PEGWLRLSLNNGSITHLVIRPNG-RVALRTLGDTGFMP .\|..\|\|\|.\|.\|\|\|.\|.\|.....\| \|\| \|..\|.\|\|.... leellrlnlpngsvtvleldddgkrvvlvllndtshle
0036777	Phosphoglycerate mutase-like	97-283	1.1e-33	109.3	In-house	2-237 (247)	alignment
Range on Protein: 97-283 Range on HMM: 2-237/247.0 TRHIFLIRHSQYH--VDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREG------------ .....\|.\|\| . ..\| . \|. \|\|.\|\|\|\|\|\|...\| .\|..\|\|\|.\|.... \| ..\|\|\|.\| .\|\| ..\|. . \| .. \|\|\| mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae --------------APIEPDPPVSHWK-------------------PEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFP \|. ..\|\|.... \|.. . . \|\|...\|......\|. .... . ..\|..\|.\|......\|... iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll...kdgenvlvVsHggvlrallayllgls PEGWLRLSLNNGSITHLVIRPNGR-VALRTLGDTGFMPP .\| .\|\|\| \|.\|\|\|\|\|.\|.....\| . \|..\|.\|\|.... ledilrlnlpngsitvleldddgklwvleslndtshlel
0043909	Phosphoglycerate mutase-like	97-284	2.3e-33	108.1	In-house	2-243 (249)	alignment
Range on Protein: 97-284 Range on HMM: 2-243/249.0 TRHIFLIRHSQYHV--DGSL--EKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLREG------------ .....\|.\|\| . .\| . \|. \|\|.\|\|\|\|\|\|...\| .\|..\|\|..\|.... \| ..\|\|\|.\| \|\| ..\|. . . .. \|\|\| mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae -------------------------------APIEPD------PPVSHWKPEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRA . . .\| \| .. \|.. . . \|\|...\|......\|.. .... . ..\|..\|.\|...... iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll...kdggnvliVaHggvlrallayl LQFPPEGWLRLSLNNGSITHLVIRPNGR--VALRTLGDTGFMPPD \|....\| .\|\|\|.\|.\|\|\|\|\|.\|.. ..\|. \| \|..\|.\|\|..... lglsledilrlnlpngsitvlelddggkpvvvlvllndtshleal
0035570	Phosphoglycerate mutase-like	100-282	4.6e-32	103.6	In-house	2-194 (219)	alignment
Range on Protein: 100-282 Range on HMM: 2-194/219.0 IFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIEPD ..\|.\|\| . . ..\| \| \|. \|\|..\|\|\|\|\|. .\| .\|\|.\|\|..\| ....\| ..\|\|\|.\| .\|\| \|. . .. \|\|\| \| \|. lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.....glpveidprLrEidfgdlegltldeiaekype PPVSHWKPEAVQYYEDG-------ARIEAAFRNYihradarqEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNG-RVALRTLG . .. . .. .\| \|\|...\|.. . \|... . ..\|..\|\|\|......\|..\|.\| .\|\|\|.\|.\|\|\|.\|.\| ....\| .. \|..\|. elaawlrdpydyrppggEsladvvaRvlpaleel........edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvlln DTGFMP \|\|.... dtshle
0039931	Phosphoglycerate mutase-like	99-283	8.8e-32	102.6	In-house	1-193 (219)	alignment
Range on Protein: 99-283 Range on HMM: 1-193/219.0 HIFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIEP ...\|.\|\| . . \|.\| \| \|. \|\|..\|\|\|\|\|. .\| \|\|..\|\|\|.\| ...\| ..\|\|\|.\| .\|\| \|. . .. \|\|\| \| \| rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.....glpveidprLrEidfgdlegltleeiaekyp DPPVSHWK-------PEAVQYYEDGARIEAAFRNYIHradarqeeDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPnGRVALRTLG . . ... \|.. . . \|\|...\|.. ... .. . ..\|..\|\|\|......\|....\| .\|\|\|.\|.\|\|\|.\|.\| ... \|.. \|..\|. eelaawlrdpydyrppggEsladvvaRvlpaleella........genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.ggwvlvlln DTGFMPP .\|..... ltshldd
0048955	Phosphoglycerate mutase-like	100-283	1.3e-31	102.7	In-house	3-230 (240)	alignment
Range on Protein: 100-283 Range on HMM: 3-230/240.0 IFLIRHSQYH--VDGSLE--KDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLLREG-------APIE---- ..\|.\|\| . ..\| \| \|. \|\|.\|\|\|\|\|\|. .\| \|\|\|.\|\|.\|\| ....\| ..\|\|\|.\| .\|\| ..\|. . \| .. \|\|\| ... lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae --PDPPVSHWK--------------------------------PEAVQYYEDGARIEAAFRNYIHRADArqeEDSYEIFICHANVIRYIVCRALQFPPEG \|. \| .. \|.. . . \|\|..\|\|.. ...\|\| .... ....\|..\|\|\|......\|..\|.\| kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk...pgknvlvVsHggvirallayllglplee WLRLSLNNGSITHLVIRPNgrvaLRTLGDTGFMPP .\|\|\|...\|\|\|.\|.\|..... \|..\|.\|\| .... ilrlnipngsvtvlelddg....lvslndtshldd
0037864	Phosphoglycerate mutase-like	96-277	1.4e-30	98.7	In-house	6-209 (211)	alignment
Range on Protein: 96-277 Range on HMM: 6-209/211.0 ATRHIFLIRHSQYHV--DGSLEK--DRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPG--VCKVSTDLL-------------R ......\|.\|\| . . .\| \| \|. \|\|.\|\|\|\|\|\|...\| .\|\|.\|\|\|.\|. ...\| ..\|\|\|.\| .\|\| ..\|. . . .. \| lmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltle EGAPIEPDPPVSHWKPEAVQYYEDG-------ARIEAAFRNYIHRAdarQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPnGR \| \| \|. .\| .. . ....\| \|\|...\|......\|. ...... . ..\|..\|.\|......\|....\| .\|\|\| \|.\|\|\|.\|.\| ... \|. eiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarl...lkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd.gg VALRTLGD . \|..\|.. wvlvslnl
0036887	Phosphoglycerate mutase-like	97-281	4.3e-29	93.9	In-house	1-201 (202)	alignment
Range on Protein: 97-281 Range on HMM: 1-201/202.0 TRHIFLIRHSQYH--VDGSLEK--DRTLTPLGREQAELTGLRLAslGLKFNKIVHSSMTRAIETTDIISRHLPgVCKVSTDLLRE-------------GA .....\|.\|\| . . \|.\| \| \|. \|\|.\|\|\|\|\|\|. .\| \|\|\| \|\|.\| ...\| ..\|\|\|.\| .\|\|...\|. . . .. \|\|\| \| mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg.lpvivdprlrEidfgalegltleeia PIEPDPPVSHWKPEAVQYYEDG-------ARIEAAFRNYIHRAdarqeEDSYEIFICHANVIRYIVCRALQFPPEGWLRLS-LNNGSITHLVIrPNGRVA \|. . .. . .. .\| \|\|..\|\|......\|. ... ....\|..\|.\|......\|....\| .\|\|\| \|.\|\|\|.\|.\| . ..\|.. ekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl.....dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel.ddggwv LRTLGDTGFM \|..\|.\|\|... lvllndtshL
0049178	Phosphoglycerate mutase-like	97-281	3.4e-28	91.3	In-house	3-232 (243)	alignment
Range on Protein: 97-281 Range on HMM: 3-232/243.0 TRHIFLIRHSQ-----YHVDGSLeKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREGA---------- .....\|.\|\| . ... . \|. \|\|.\|\|\|\|\|\|...\| .\|\|.\|\|\|\|\|. .. \| ..\|\|\|.\| .\|\| ..\|. . \| .. \|\|\| mtrlyLvRHGetewnaegrlqgw.tDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka ----------------PIEPDPPVSHW-----------------KPEAVQYYEDGARIEAAFRNYIHRADarqEEDSYEIFICHANVIRYIVCRALQFPP \| . \|\|. .. \|.. . . \|\|...\|........ ... . ..\| .\|\|\|......\|. \|. eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell...hdgktvlvVaHggvirallalllglpl EGWLRLSLNNGSITHLVIRPnGRVALRTLGDTGFM \| .\|\|\| \|.\|\|\|.\|.\| . . \|.. \|..\|.\|\|... eellrlnlpngsvtvleldd.ggwvlvslndtshl
0053607	Phosphoglycerate mutase-like	98-270	3.7e-28	90.8	In-house	2-183 (191)	alignment
Range on Protein: 98-270 Range on HMM: 2-183/191.0 RHIFLIRHSQYH--VDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIIsrhlpGVCKVSTDLLREG-------------APIE ....\|.\|\| . . ..\| \| \|. \|\|.\|\|\|\|\|\|.... .\|\|.\|\|\|\|\| ....\| ..\|\|..\| .\|\| \|. . .. \|\|\| \| trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.....glpvevdprlrEidfgdwegltleelaeky PDPPV-------SHWKPEAVQYYEDGARIEAAFRNYIHradarqeeDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRV \|. . .. \|.. ... \|\|...\|...... .. . ..\|..\|\|\|......\|..\|.\| .\|\|\|.\|.\|\|\|.\|.\| ....\| \| peelaawlrdpldyrppggEsladvaaRvlpaleella........ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwv
0050036	Phosphoglycerate mutase-like	100-266	8.6e-20	63.2	In-house	3-169 (171)	alignment
Range on Protein: 100-266 Range on HMM: 3-169/171.0 IFLIRHSQYHVD--GSLE--KDRTLTPLGREQAELTGLRLaslglKFNKIVHSSMTRAIETTDIISrhlpgVCKVSTDLLRE----------------GA ..\|.\|\| . . . \| . \| \|\|.\|\|\|.\|\|. .\| .\| .\| ...\| ..\|\|..\| ..\| . . .. \|\|\| lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.....lpvivdprLrErdfGawegltldeiaaky PIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIhradarqeedSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRP \| .. .. \|.. ... \|\|. .\|..... . . ..\|..\|\|\|......\|. ..\| .\|\|\| \|.\|\|\|...\| . . pewlldlldlappggEsladvlaRvlpaleell..........gnvlvvaHggvirallalllglsleeilrlelpngsvlvleldd
His_Phos_1	Histidine phosphatase superfamily (branch 1)	99-236	6.1e-17	55.0	Pfam-A	1-157 (158)	alignment
Range on Protein: 99-236 Range on HMM: 1-157/158.0 HIFLIRHSQ--YHVDGSLEKDRT--LTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP-------GVCKVSTD----LLREGAPIEP ...\|.\|\| . .. .\|.\|... \|\|. \|\|\|\|\|. .\| .\|.. .\|...... \| ..\|\|\|.\|..\|.. .\| .. ... . \| .\| .. \| rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef DPPVSHWKP--------EAVQYYEDGARIEAAFRNYIHradARQEEDSYeIFICHANVIRY . . .\|\| \|. .. . .\|........\|. \|...... . ..\|..\|.\| peeyekwkrdkkefrppegesladvyeRvapfleelie...akdkgenv.livsHggvlra
His_Phos_1	Histidine phosphatase superfamily (branch 1)	99-236	6.1e-17	55.0	In-house	1-157 (158)	alignment
Range on Protein: 99-236 Range on HMM: 1-157/158.0 HIFLIRHSQ--YHVDGSLEKDRT--LTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP-------GVCKVSTD----LLREGAPIEP ...\|.\|\| . .. .\|.\|... \|\|. \|\|\|\|\|. .\| .\|.. .\|...... \| ..\|\|\|.\|..\|.. .\| .. ... . \| .\| .. \| rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef DPPVSHWKP--------EAVQYYEDGARIEAAFRNYIHradARQEEDSYeIFICHANVIRY . . .\|\| \|. .. . .\|........\|. \|...... . ..\|..\|.\| peeyekwkrdkkefrppegesladvyeRvapfleelie...akdkgenv.livsHggvlra
subfamily_STS_pd	Subfamily STS	113-219	4.2e-08	24.9	In-house	48-153 (245)	alignment
Range on Protein: 113-219 Range on HMM: 48-153/245.0 SLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLP--GVCKVSTDLLREGAPIEPDpPVSHWKPEAVQyyEDGARIEAAFRN ....\| \|\| \| \|\|.\|.\| .\| . \|.\| . \|. \| ..\| \|.\|. \| \| \|\| . \|\| .. . . ..\|\|... . . .\|. .. dyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglgkkikikvepgllewlkldrkp.ipellspeelk..kffpqidedYkp YIHRADARQ . . .. vlslselks
subfamily_TIGAR_pd	Subfamily TIGAR	116-164	8.8e-08	24.1	In-house	23-69 (222)	alignment
Range on Protein: 116-164 Range on HMM: 23-69/222.0 KDRTLTPLGREQAELTGLRLAslGLKFNKIVHSSMTRAIETTDIISRHL \| \|.. \|.\|\|\|.... \|\|. \|.\| \|. \| \|\| .\|..\|\| ..\| tdtpLsekGveQakrvakrLs..nekinyifsSdllRAkqTaeiilkal
subfamily_PGAM_pd	Subfamily PGAM	100-164	1.9e-07	22.6	In-house	3-71 (248)	alignment
Range on Protein: 100-164 Range on HMM: 3-71/248.0 IFLIRHSQYHVDGSL----EKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHL ..\|.\|\| . ... .\| \|.. \|.\|.\|. .\| \| . .\|.\|.... \| ..\|\|..\|...\| .\| lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileel
0053031	Phosphoglycerate mutase-like	99-178	7.7e-06	18.6	In-house	6-105 (342)	alignment
Range on Protein: 99-178 Range on HMM: 6-105/342.0 HIFLIRHS----QYHVDGSLEKD-------RTLTPLGREQAELTGLRLASL---------GLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREG \|.\|.\|\| ... . . .. \|\|\|\|\|\|\|\|\| .\| \|\| .. . .. \|.. \|.... . . \| . .. . . . \| vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg

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