Gene UBASH3B in Homo sapiens

Synonym: STS-1, STS1, TULA-2, TULA2, p70, UBASH3B

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily STS
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP156_AA protein Get Run
HsapP156_AA_382-635 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_STS_pd Subfamily STS 384-634 2e-97 317.4 In-house 1-244 (245) alignment 
Range on Protein: 384-634
Range on HMM: 1-244/245.0
RCLFVCRHGERMDVVFGKyWLSqCFDaKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILK
|.....|||||.|.|||| ||. .|| .|.| |..||.|..||.|..|..||..| |.| .|..||.|.|.||||... |.|..|||||||.|||..|||
rtiyivRhgeRvdevfgk.Wlk.sfd.egkyerkdlnlpkelprrpdglkdyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailk

GLQqeNHLKIRVEPGLFEWTKWVAGStLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISECkSKGNNILIVAHASSLEAC
||.  ...||.|||||.||.|. ... .| ...|.||. .....|..|.|... |.|. .||......|...|.||||... .. .||||||||..|.|.
glg..kkikikvepgllewlkldrkp.ipellspeelkkffpqidedYkpvlslselkskeseeelyeRikkvvkeiiekv.pedgniliVahaatldal

TCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTH
..||.||||..|.|. ..|.|.||......||  |.. |.|||..||.|..
srqllglspresedlkklvikspycslakleenkeerkwkltdsgilsllk
subfamily_Cele-STS-like_pd Subfamily Cele-STS-like 387-634 9.8e-51 163.3 In-house 3-228 (229) alignment 
Range on Protein: 387-634
Range on HMM: 3-228/229.0
FVCRHGERMDVVFGKyWLSQcFDAKGRYIRTNLNMPHSLPQRSggfRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQ
.| |..||.| |||| |. . .| ...|  ...|.|..||.|.   . |. |.|.|  | ....|.| ||..   .. .|.||| ||.||||. .|||| 
vvirsaervdevfgk.Wiks.adletkyrpldinvPkelpkra...ksykldpPlteiGkiaskligRaLrdrgiepsvvFCSPdlrsvqtaalllkglG

QeNHLKIRVEPGLFEwtkwvAGSTLPAWIPPSELAAANLSVDTTYRPHipiSKLVVSESYDTYISRSFQVTKEIISECKSKgnNILIVAHASSLEACTCQ
. .  .|.|||||.|     .  . . ..|| .. . .  || .| |     .|  .|| . .  |.... |...|... |  .||.||.. ||| .. .
l.kraaisvePgLle.....yrkarevllppkafkklgypvdekYkPl...kelsmaeslsdfvariqaafkkllskveqk..lilvvadnvsleltrre

lqglSPQNSKDFVQMVRKIPYlgfCSCEELG-ETGIWQLTDPPILPLTH
      .  .|......| |.   .|. ..    | ... | |.|.|..
....dvesvddllvllkktpa...lsvvivnlkkGearivdspvlllsk
0036777 Phosphoglycerate mutase-like 385-635 4.4e-38 123.6 In-house 4-240 (247) alignment 
Range on Protein: 385-635
Range on HMM: 4-240/247.0
CLFVCRHGERMDVVfgkywlsqcfdakgryirtnlnmphslpqrSGGFRDYeKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKG
 |...|||| .. .                              .| | .   |.|.|  | .||...||.| | .  .|.||.|| ||..|||. ||..
rlyLvRHGetewna..............................egrfqgw.lDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilea

LQQEnHLKIRVEPGLFEW---------------------TKWVAGStLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISE
|... .|...|.|.| |.                      .| ... .....|..||  ..| .|.......|. .|   ||.  .. |  .. .|.. .
lgls.llpvvvdprLrErdyGalegltkaeiaekypeelvawwrdp.ydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellar

CKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFvqmvrKIPYLGFCSCEELGETGIWQLT---DPPILPLTHG
.  .|.|.|.|.|. .| |....| |||...  ..     ..|. ... .|  .....|.|.   |...|.|.. 
llkdgenvlvVsHggvlrallayllglsledilrl.....nlpngsitvleldddgklwvleslndtshlelgle
0043909 Phosphoglycerate mutase-like 384-607 4.3e-36 117.0 In-house 3-213 (249) alignment 
Range on Protein: 384-607
Range on HMM: 3-213/249.0
RCLFVCRHGERMDVVFGKYwlsqcfdakgryirtnlnmphslpqrsggfrDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILK
. |...|||| .. . |..                                   |.|.|  | .|||..|||| | .  .|.||.|| .|..|||. ||.
krlyLvRHGetewnaegrf...............................qgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiile

GLQQENhLKIRVEPGLFEW-----------------------TKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKLVV-SESYDTYISRSFQVTKE
.|.... |...|.|.| |.                        ...  ..|| ..... .  ..|..|.......| .  .   ||.  .. |  .. .|
elgldk.lpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpalee

IISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFvqmvrKIPY
.. ..  .|.|.|||||. .| |....| |||...  ..     ..|.
llarllkdggnvliVaHggvlrallayllglsledilrl.....nlpn
0051064 Phosphoglycerate mutase-like 384-625 5.2e-33 107.4 In-house 4-228 (241) alignment 
Range on Protein: 384-625
Range on HMM: 4-228/241.0
RCLFVCRHGERMDVVFGKYWLsqcfdakgryirtnlnmphslpqrsggfrdyEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILK
. |...||||... . |...                                  |.|.|  |  ||| .||.| . .  .|.||.|| ||..|||. |..
krlyLvRHGesewnaegrlqg...............................wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiae

GLQQEnHLKIRVEPGLFEWTKWV-AGSTLPAWIP--PSELAAANLSVDTTYRPHIPISKL-----------------VVSESYDTYISRSFQVTKEIISE
.|... .|...|.|.| |.   .  | ||. .    | ||.|   .  ... |.. ...|                    ||.. .. |  .. .|....
alglp.llpvvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellar

CKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFvqmvrKIPYLGFCSCEELGETGIWQLT
.  .|.|.|.|.|. .. |....| ||...   ..     ..|. ... .|  .... ..| 
llldgknvlvVsHggvirallayllglpleellrl.....nlpngsvtvleldddgkrvvlv
0048955 Phosphoglycerate mutase-like 386-632 6.3e-33 107.0 In-house 3-230 (240) alignment 
Range on Protein: 386-632
Range on HMM: 3-230/240.0
LFVCRHGERMDVVFGKYWLsqcfdakgryirtnlnmphslpqrsggfrdyEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGL
|...||||... ..|...                                  |.|.|  |  ||| .||.| . .  .|.||.|| ||..|||. |...|
lyLvRHGesewnaegrlqg...............................wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaeal

QQENhLKIRVEPGLFEW---------------------TKWVAGSTLPAWIPPSELAAANLSVDTTYRpHIPISKLVVSESYDTYISRSFQVTKEIISEC
.... |...|.|.| |.                      .| ...  ... . . |    |..|..|  ... . |   ||.. .. |  .. .|.....
glpl.lpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlrya.lldedllpggEsladvaaRvlaaleellara

KSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFvqmvrKIPYLGFCSCEELGEtgIWQLTDPPILPL
  .|.|.|.|.|. .. |....| ||...   ..     .||. ... .|  ..  .. | | ..|. 
lkpgknvlvVsHggvirallayllglpleeilrl.....nipngsvtvlelddg..lvslndtshldd
0049178 Phosphoglycerate mutase-like 416-599 1.4e-31 102.4 In-house 24-205 (243) alignment 
Range on Protein: 416-599
Range on HMM: 24-205/243.0
RtnlnmphslpqrsggfrdyEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQENhLKIRVEPGLFEW-------------
                      |.| |  |  |||..||.| | .  .|.||.|| .|..|||. ||..|.... |...|.|.| |.             
g...................wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpl.lpvvvdprLrErdfGalegltkaei

-----TKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKD
       .||  . | ...|  |   .| .....| ....  |   ||.. .. |  .. .|.. |.  .|...|.|||  .. | ...| ||...   .
aakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellr

FV
. 
ln
0037864 Phosphoglycerate mutase-like 383-613 4.3e-31 100.4 In-house 7-195 (211) alignment 
Range on Protein: 383-613
Range on HMM: 7-195/211.0
KRCLFVCRHGERMDVVFGKYWlsqcfdakgryirtnlnmphslpqrsgGfrdyEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNIL
 . |...||||... . |...                           |      |.|.|  | .|||..|||| . .  .|.||.|| ||..|||. ||
mtrlyLvRHGetewnaegrlq...........................g....wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiil

KGLQQEnHLKIRVEPGLFEWTKWVAGSTLPAWIPP---SELAAANLSVDTTYRPHIpisklvvsESYDTYISRSFQVTKEIISECKSKGNNILIVAHASS
..|... .|...|.|.| |.  ..      . |      ||.|   .  ... |.         ||.  .. |  .. .|.. .. ..|.|.|.|.|. .
ealglp.llpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrppgg........EsladvvaRvlpaleellarllkdgenvlvVsHggv

LEACTCQLQGLSPQNSKDFvqmvrKIPYLGFCSC
| |....| |||...  ..     ..|. ... .
lrallayllglsleellrl.....nlpngsvtvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 386-583 4.5e-27 87.9 Pfam-A 2-158 (158) alignment 
Range on Protein: 386-583
Range on HMM: 2-158/158.0
LFVCRHGERMdvvfgkywlsqcfdakgryirtnlnmpHSLPQRsggfRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGL
|...||||.                            .. ..|     . ..|.|.|  |  ||| .|..| ...  ||.||.||..|..|||. .|..|
lylvRHGese...........................wnkegr....lqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleel

QqenhLKIRVEPGLFEWTK--WvagSTLPAWIPPSELAAANLSVDT---TYRPHipisklvVSESYDTYISRSFQVTKEIISeCKSKGNNILIVAHASSL
.    ..|. ||.| |.    |     || .  ..|. ... . ..    .||.         ||.. .. |  .. .|.|.  |.||.|.|||.|...|
d....ipiikeprLrerdfgew...eglpkeevkeefpeeyekwkrdkkefrpp.......egesladvyeRvapfleelie.akdkgenvlivsHggvl

EAC
.|.
ral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 386-583 4.5e-27 87.9 In-house 2-158 (158) alignment 
Range on Protein: 386-583
Range on HMM: 2-158/158.0
LFVCRHGERMdvvfgkywlsqcfdakgryirtnlnmpHSLPQRsggfRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGL
|...||||.                            .. ..|     . ..|.|.|  |  ||| .|..| ...  ||.||.||..|..|||. .|..|
lylvRHGese...........................wnkegr....lqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleel

QqenhLKIRVEPGLFEWTK--WvagSTLPAWIPPSELAAANLSVDT---TYRPHipisklvVSESYDTYISRSFQVTKEIISeCKSKGNNILIVAHASSL
.    ..|. ||.| |.    |     || .  ..|. ... . ..    .||.         ||.. .. |  .. .|.|.  |.||.|.|||.|...|
d....ipiikeprLrerdfgew...eglpkeevkeefpeeyekwkrdkkefrpp.......egesladvyeRvapfleelie.akdkgenvlivsHggvl

EAC
.|.
ral
0036887 Phosphoglycerate mutase-like 385-599 1.6e-26 85.6 In-house 3-173 (202) alignment 
Range on Protein: 385-599
Range on HMM: 3-173/202.0
CLFVCRHGERMDVVFGKYWLSQcfdakgryirtnlnmphslpqrsggfrdyekDAPITVFGCMQARLVGEALLesNTIIDHVYCSPSLRCVQTAHNILKG
 |...||||... | |..                                   |.|.|  | .||| .||.|.  .  .|.||.|| ||..|||. |...
rlyLvRHGetewnvegrlqgdl...............................dvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaea

LQqenhLKIRVEPGLFEWTKWVAGSTLPAWIPP---SE---------------LaaanlsvdttyrphipisklvvsESYDTYISRSFQVTKEIISECks
|.    |...|.|.| |.  ..      . |      |                                       ||.  .. |  .. .|.. ..  
lg....lpvivdprlrEidfgalegltleeiaekypeelaawlrdpydfrppgg.......................EsladvvaRvlaaleellarl..

KGNNILIVAHASSLEACTCQLQGLSPQNSKDFV
.|.|.|.|.|. .| |. ..| |||...  .. 
dggnvlvVsHggvlrallayllglsledllrlr
0035570 Phosphoglycerate mutase-like 386-624 2.8e-25 81.5 In-house 2-184 (219) alignment 
Range on Protein: 386-624
Range on HMM: 2-184/219.0
LFVCRHGERMDVVfgkywlsqcfdakgryirtnlnmphslpqrS---GGfrdyekDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNIl
|...||||... .                              .    |      |.|.|  |  ||| .|||| . .  .|.||.|| ||..|||. | 
lyLvRHGetewnl..............................egrlqg......dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.

kglqqenHLKIRVEPGLFEWTKWVAGSTLPAWIPP---SELAAANLSvDTTYRPHipisklvVSESYDTYISRSFQVTKEIiseckSKGNNILIVAHASS
       .|.....|.| |.   .      ..|      ||||   . . .|||.         ||.  .. |  .. .|.      .|.|.|.|.|. .
.......glpveidprLrEidfgdlegltldeiaekypeelaawlrd.pydyrpp.......ggEsladvvaRvlpaleel.....edgenvlvVsHggv

LEACTCQLQGLSPQNSKDFVqmvrkIPYLGFCSCEELGETGIWQL
. | ...| ||....  ..      .|. ...  |  |..| |.|
irallayllglpleeilrln.....lpngsvtvleldggggkwvl
0039931 Phosphoglycerate mutase-like 387-598 6.6e-24 77.0 In-house 3-163 (219) alignment 
Range on Protein: 387-598
Range on HMM: 3-163/219.0
FVCRHGERMDVVfgkywlsqcfdakgryirtnlnmphslpqrS---GGfrdyekDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNIlk
...|||| .. |                                   |      |.|.|  |  ||| .||.| . .  .|.||.|| ||..|||. |  
yLvRHGetewnv..............................egrlqg......dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii..

glqqenHLKIRVEPGLFEWTKWVAGSTLPAWIPP---SELAAANLSvDTTYRPhipiSKlvvSESYDTYISRSFQVTKEIISeckskGNNILIVAHASSL
      .|.....|.| |.   .      ..|      ||||   . . .|||    ..    ||.  .. |  .. .|...     |.|.|.|.|. ..
......glpveidprLrEidfgdlegltleeiaekypeelaawlrd.pydyrp....pg...gEsladvvaRvlpaleella.....genvlvVsHggvi

EACTCQLQGLSPQNSKDF
 | ...| |||..   ..
rallayllglsleeilrl
0053607 Phosphoglycerate mutase-like 434-595 1.2e-21 69.6 In-house 22-162 (191) alignment 
Range on Protein: 434-595
Range on HMM: 22-162/191.0
DyekDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNIlkglqqenHLKIRVEPGLFEWTKWVAGSTLPAWIPPS--ELAAANLSVDTTY
    |.|.|  |  |||...|.| | .  .|.||.|| ||..|||. |        .|...|.|.| |.   .      ...     |. || |  . .|
g...dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii........glpvevdprlrEidfgdwegltleelaekypeelaawlrdpldy

RPhiPisklvVSESYDTYISRSFQVTKEIISeckskGNNILIVAHASSLEACTCQLQGLSPQNS
||  |       ||.. .. |  .. .|...     |.|.|.|||. .. | ...| ||.... 
rp..p.....ggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglpleel
SH3_9 Variant SH3 domain 261-315 4.9e-20 60.1 Pfam-A 1-49 (49) alignment 
Range on Protein: 261-315
Range on HMM: 1-49/49.0
VIYPYTPQNDDELELVPGDFIFMSPMeqtsTSEGWIYGTsLtTGCSGLLPENYIT
..|.|.|..||||.| .||.|....     |..||..|. | ||..||.|.||..
AlydyepkdddELslskGdvitvlee....tedgWllGe.l.tGrtGlvPanyVe
0050036 Phosphoglycerate mutase-like 437-595 3.8e-18 57.9 In-house 23-152 (171) alignment 
Range on Protein: 437-595
Range on HMM: 23-152/171.0
KDAPITVFGCMQARLVGEALlesntIIDHVYCSPSLRCVQTAHNILkglqqenhLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAaanlsvdttYRPHIP
 | |.|  | .||| .||.|      .|.||.|| ||..|||. ||        |...|.|.| |.   .      . |.              .  ...
tdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil........lpvivdprLrErdfGawegltldeiaakype.........wlldll

ISKLVVSESYDTYISRSFQVTKEIIseckskgNNILIVAHASSLEACTCQLQGLSPQNS
   .   ||.  .. |  .. .|..       .|.|.|||. .. |  ..| |||..  
dlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglsleei
0047369 Phosphoglycerate mutase-like 386-593 4.6e-11 35.6 In-house 48-252 (438) alignment 
Range on Protein: 386-593
Range on HMM: 48-252/438.0
LFVCRHGERM------DvvfGKYWLSQCFDAKGRYIRTNLNMPHSLPqRSGGFRDyekdapITVFGCMQARLVGEALLE-----SNTIIDHVYCSPSLRC
  . |||.|       .   . ..| ..... . |.. .|.. ....  . |. .       | .|  ||. .|. | .     ..  . .|..|.. |.
qvlfRHGaRtPtksklk...kleplwellenattypsgplsflndwl.gpcgagq......LTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRt

VQTAHNILKGLQQENHLKIRVEPGLFewtkwvagstlpawipPSELAAANLSVDTTYR--PHIPISKLVV--------SESYDTYISRSFQVTKEIISEC
.|.| . |.|| .... ... .. .                 |  .   . |.|. ..  |. . ...          .|  ... ..  .. |.... .
lqSAqaflaGlfppegtgelapilwq................pipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpgl

KSKGNNILIVAHASSLEACTCQLQGL--SPQ
.   ...| . .  . . . ..  ||  || 
nltpsdvldlydlcaydtlangyaglplspf
subfamily_TIGAR_pd Subfamily TIGAR 437-502 4.7e-11 34.8 In-house 23-86 (222) alignment 
Range on Protein: 437-502
Range on HMM: 23-86/222.0
KDAPITVFGCMQARLVGEALLesNTIIDHVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEW
 | |..  |  || .|.. |   |  |.... |. ||  |||. ||| |........ ... | |.
tdtpLsekGveQakrvakrLs..nekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEr
0053031 Phosphoglycerate mutase-like 387-592 3.7e-10 32.8 In-house 8-193 (342) alignment 
Range on Protein: 387-592
Range on HMM: 8-193/342.0
FVCRHGERMDVVFGK-------YWlsqcfdakgryirtnlnmphslpqrsggfrdyeK--DAPITVFGCMQARLVGEALLES----------NTIIdHVY
.. |||.|  ...|.       ..                                 .  . . | .|  ||. .|..| .           .... .|.
vlvRHGaRtPlskgpldplnewfy.................................pcgageLTplGreqayelGrrlrkrYlgllpstynpdev.yvr

CSPSLRCVQTAHNILKGLQQENH------------LKIRVEPGLFEWTKWVAGSTLPAwippselaaanlsvdttyrPHIPISKLVVSESYDTYISRSFQ
 |.. |..|.| ..|.|| ....            ..| .||  ....     .. ||                       ...   || ......|  .
ssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpa...................fdkllkealaseevkelleryle

VTKEIISECKSKGNNIL--IVAHASSLEACTCQLQGLSP
. ..... .. . .. |  .    ..| . ...  .|.|
llqklskglgltlsdlldlvsdlydlllyelahglplpp
0049059 Phosphoglycerate mutase-like 386-570 2.7e-09 29.6 In-house 47-225 (435) alignment 
Range on Protein: 386-570
Range on HMM: 47-225/435.0
LFVCRHGERM---DVVFGKYWLSQCFDAKGRYIRtnlnmphslpqrsG------------GfrdyekDAPITVFGCMQARLVGEALLE------SNTIId
  . |||.|     .  .   | ...    .| .             |            |      .   | .|  ||.  |. | .      ... . 
qvlfRHGaRtPtsklikklealwekllslltypn.............gplsflndwnyplg......ageLTplGreqayelGkrlrkrYgfLynpdev.

HVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEWTKWVAGsTLPAWIP---PSELAAANLSVDTTYrphipisklVVSESYDTYISRSFQVTKEII
.|. |.. |..|.| . |.|| ....|.......| ...  .   | .....   ..  .| . ...  .           .|  ... .|  .. .|..
yvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpie.tvdsdndtlpydscpafdellkell.........asdeflelflerilkllqell

SECKSKGNN
.... . ..
pglgltpsd
2_5_RNA_ligase2 2'-5' RNA ligase superfamily 107-234 3.3e-09 25.3 Pfam-A 8-135 (153) alignment 
Range on Protein: 107-234
Range on HMM: 8-135/153.0
FWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKvDALGEALQTTVSRWKCkfsapLPLELYTSSNFIG----LFVKEDSAEVLKKFAADFAAEAASKTEV
.... .. ..  ....  |||||.  |  ...  ..| |.|........      ....|   . | .    .... .. | |... |. ... .   ..
piealrrslydkayprwppHiTLlypfvepedl.qdlaellsrlaaetep.....fevrldgvgvFehkksvvylevspseslsaLraallealpeaglk

HVEPHKKQLHVTLAYHF-QASHLPTLEKL-AQNI
. . .. . |.|.|.   ..|.   ||||  .. 
edstgeftPHlTiaqsedstsakelleklagalp
subfamily_TFC7_pd Subfamily TFC7 431-590 5.7e-09 26.9 In-house 23-180 (255) alignment 
Range on Protein: 431-590
Range on HMM: 23-180/255.0
GFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQqenhLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLS-VDT
  .  ..|.|..  |  ||. ... |.. ..  . ...||  ||..|.. | . |.    . ..|. |. || |      ..  .   .|     | ...
pltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeele....iPvyvdrGvgewykpdrrPvilePasnevlskffPsvisl

TYRPHI-PISKLVVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGL
 | . . |. |    |     . . . |  . . .   . . ||||.||..  |   .| . 
dyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsllky
0049226 Phosphoglycerate mutase-like 387-565 7.4e-09 28.4 In-house 8-164 (342) alignment 
Range on Protein: 387-565
Range on HMM: 8-164/342.0
FVCRHGERMDVVFGKYWLSQCFDakgryirtnlnmphslpqrsggfrdyeK---DAPITVFGCMQARLVGEALLES---------NTIIDHVYCSPSLRC
.. |||.|  ...|...  .                                  . . | .|  ||. .|..| .          |  . .|. |.. |.
vliRHGdRtPlakgpldflnewf...........................wgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRt

VQTAHNILKGLQQENHLKIRVEPGLfewtkwvagstlpawippselA------AANLSVDTTYRP--------HIPISKLVVSESYDTYISRSFQVTKEI
.|.| ..|.|| ....  | |                                  . | ||. ..        .  ...|  || .. ....  .. |..
lqSaqaflaGlfppeltpilvplld.....................wqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkkl

ISECK
 . ..
skllg
UBA UBA/TS-N domain 42-73 9.1e-09 23.5 Pfam-A 7-37 (37) alignment 
Range on Protein: 42-73
Range on HMM: 7-37/37.0
DVLLSMGFPRARAQKALASTGGrSVQAACDWL
  |. |||.| .|.||| .|.. .|..| ..|
qqLreMGfsreeakkALratnn.nverAveyL
SH3_1 SH3 domain 261-310 1.1e-08 23.6 Pfam-A 2-47 (48) alignment 
Range on Protein: 261-310
Range on HMM: 2-47/48.0
VIYPYTPQNDDELELVPGDFIFMSPMEQTstseGWIYGTSLTTGCSGLLP
..|.|.....||| . .|| |.   .. .    ||  | . .||  || |
AlYDYearesdELsfkkGDviivleksed....gWwkgrlkgtgkeGliP
subfamily_PGAM_pd Subfamily PGAM 437-489 6.7e-08 24.1 In-house 23-75 (248) alignment 
Range on Protein: 437-489
Range on HMM: 23-75/248.0
KDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQEN
.|| ..  |  .|. .|.|| ..|  .| ||.|   |..||.. ||. |.||.
vDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqek
0048439 Phosphoglycerate mutase-like 387-502 1.7e-07 24.1 In-house 14-123 (391) alignment 
Range on Protein: 387-502
Range on HMM: 14-123/391.0
FVCRHGERMDV---V--FGKYWLSqcfdakgryirtnlnmphslpqrsgGFRDYEKD-APITVFGCMQARLVGEALLE--------------SNTIIdHV
 . |||.|  .      . ... .                          .. .. .  . | .|  |..  |..| .              ..... .|
vlfRHGaRtPtssypnkldpllnk.........................llpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsev.yv

YCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEW
..|.. |..|.| . |.|| ....|.. . . . ..
rssdvdRtlqSAqaflaGlfpplgltvilvivvese
0048946 Phosphoglycerate mutase-like 386-508 2.3e-07 23.2 In-house 45-160 (447) alignment 
Range on Protein: 386-508
Range on HMM: 45-160/447.0
LFVCRHGERM---DVVFGKYWLSQCFDAKgryirtnlNmPHSLPQRSGGFRDYEKD-----------APITVFGCMQARLVGEALLE-------SNTIID
  . |||.|    .. .| ..| .....         | .. |.   ....|....              | .|  |.. .|..| .       ... | 
qvlfRHGaRtPtkkylkgleplldllkna........n.vlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllpnpseiy

hVYCSPSLRCVQTAHNILKGLQQENhlkirvepglfewtkwvaG
 |. |.. |..|.| . |.|| . .                  .
.vrssdvdRtlqSaqaflaGlfppe..................p
0046349 Phosphoglycerate mutase-like 387-499 6.1e-07 22.1 In-house 12-117 (409) alignment 
Range on Protein: 387-499
Range on HMM: 12-117/409.0
FVCRHGERMDVVF--------GKYWLsqcfdakgryirtnlnmphslpqrsggfrDYEKD-APITVFGCMQARLVGEALLES---NTI----------ID
.. |||.|  ..         |..|                               .. .  . | .|  ||. .|..| .      .          . 
vlfRHGaRtPtkklsflpnwpginwt.............................ngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdei

HVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGL
.|. |.. |..|.| ..|.|| .... .|   .  
yvrssdvdRtlqSAqaflaGlfpplggeivpllrq
subfamily_PGAM_pd Subfamily PGAM 526-597 2.4e-06 19.0 In-house 134-204 (248) alignment 
Range on Protein: 526-597
Range on HMM: 134-204/248.0
SVDTTYRpHIPISKLVVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKD
. |. |  ... ..|  ||| .  ..|   | .| | .   .|...||||| .|. |    |.|.| .. |.
nkdrrye.elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaike