Gene TIGAR in Homo sapiens

Synonym: FR2BP, TIGAR, C12orf5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily TIGAR
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP157_AA protein Get Run
HsapP157_AA_3-265 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TIGAR_pd Subfamily TIGAR 4-266 4.5e-89 289.9 In-house 1-222 (222) alignment 
Range on Protein: 4-266
Range on HMM: 1-222/222.0
FALTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSEL
|.|.|||||||.||||||.||| .|.||||.|..||.... .|.| |....|||||.|.|||.. ||...|..|...|..|.|||||.|||.||.||.||
filivVrhGetefnkekilqgq.tdtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

RAMAKAAReECPVFTPPGGETLDQVKMRGIDFFEFLC-QLILKEADQKEqfsqgspsncletslaeifplgknhsskvnsdSGIPGLAASVLVVSHGAYM
|...|||. ..| |.|.|||...|...| ....|.|| ... .|||.|.                                .|..| ...|||||||...
rellkaag.nvpsfvpegGesieqlelrlvaaleelcakilhleadkkk................................dgaegelthvlvvshglal

RSLFDYFLTDLKCslpatlSRSELMSVTPNTGMSLFIInfEEGREVKPTVQCICMNLQDHLNGL
|.|.......|..      ....|.....||..| ...  |..|..|..||..|..|..|||||
rellnvlhvelsv......gklrlakgsrntdlstlvv..eierdgkqsvqvaclylkehlngl
0043909 Phosphoglycerate mutase-like 6-265 6.9e-42 135.9 In-house 5-242 (249) alignment 
Range on Protein: 6-265
Range on HMM: 5-242/249.0
LTVVRHGETRFNKEKIIQGqGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGILERSKFCKdMTVKYDSRLRERKYGVVEGKALSEL
| .|||||| .|.|...||  .| ||.|.| .||.|.| .|   ...|....||.| |..||.. |||  .. | . |..| ||||| .|. ||. ..|.
lyLvRHGetewnaegrfqg.wlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldk.lpvevdprLrErdfGalegltkaei

RAMAKAARE---------------------------------ECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADqkeqfsqgspsncletslaeif
...   .                                   . . ..|||||.| .|  | ....| |.. .||. .                      
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdgg......................

plgknhsskvnsdsgipglaaSVLVVSHGAYMRSLFDYFLtdlKCSLPATLSRselmsVTPNTGMSLFIInfeeGREVKPTVQCICMNLQDHLNG
                      ||.|.||. .|.|. |.|   ..||.. |.        ||.... . .      . ||.|.. ..|  .||. 
.....................nvliVaHggvlrallayll...glsledilrl.....nlpngsitvlel....ddggkpvvvlvllndtshlea
0036777 Phosphoglycerate mutase-like 6-264 4.9e-41 133.3 In-house 5-236 (247) alignment 
Range on Protein: 6-264
Range on HMM: 5-236/247.0
LTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGILERSKFCkDMTVKYDSRLRERKYGVVEGKALSEL
| .|||||| .|.|...||. .| ||.|.| .||.|.| .| .  ..|....||.|.|. ||.. |||. ..   . |..| ||||| ||. ||. ..|.
lyLvRHGetewnaegrfqgw.lDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealgls.llpvvvdprLrErdyGalegltkaei

RAMAKA----AREECPVFTP-------------------------PGGETLDQVKMRGIDFFEFLCQLILKEADqkeqfsqgspsncletslaeifplgk
...  .     .     ..|                         ||||.| .|  | ....| |.. .||. .                          
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdge..........................

nhsskvnsdsgipglaaSVLVVSHGAYMRSLFDYFLtdlkcS--LPATLSRselmsVTPNTGMSLFIINFEEGrevkpTVQCICMNLQDHLN
                  |||||||. .|.|. |.|     .  | . |.        ||.... . .. ...     .......|  .||.
.................nvlvVsHggvlrallayll.....glsledilrl.....nlpngsitvleldddgk.....lwvleslndtshle
0049178 Phosphoglycerate mutase-like 4-264 1.1e-40 132.1 In-house 4-233 (243) alignment 
Range on Protein: 4-264
Range on HMM: 4-233/243.0
FALTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGILERSKFCKdMTVKYDSRLRERKYGVVEGKALS
  | .|||||| .|.|...||. .| ||.|.| .||.|.| .|   ..||....||.| |..||.. |||. .. . ..|..| ||||| .|. ||. ..
trlyLvRHGetewnaegrlqgw.tDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpl.lpvvvdprLrErdfGalegltka

ELRAM----AKAAREECPVFTP-----------------------PGGETLDQVKMRGIDFFEFLCQLILKEADqkeqfsqgspsncletslaeifplgk
|..|.      | ..    ..|                       ||||.|..|  | ....| |.. .|.. .                          
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgk..........................

nhsskvnsdsgipglaaSVLVVSHGAYMRSLFDYFLtdlkcslpaTLSR------SelmsvTPNTGMSLFIInfEEGRevkptVQCICMNLQDHLN
                  ||||.||. .|.|  ..|          |.              ||.... . .  ..|.     ......|  .||.
.................tvlvVaHggvirallalll.........glpleellrln.....lpngsvtvlel..ddgg.....wvlvslndtshld
0051064 Phosphoglycerate mutase-like 5-265 1.9e-39 128.4 In-house 5-238 (241) alignment 
Range on Protein: 5-265
Range on HMM: 5-238/241.0
ALTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGILERSKFCkDMTVKYDSRLRERKYGVVEGKALSE
 | .|||||. .|.|...||.  | ||.|.| .||.|.| .| .  .||....||.| |. ||.. |.|. ..  ...|..| ||||. .|. ||. |.|
rlyLvRHGesewnaegrlqgw.tDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglp.llpvvvdprlrEidfgalegltlee

LRAMAKAAR----EECPVFTP-------------------------PGGETLDQVKMRGIDFFEFLCQLILKEADQkeqfsqgspsncletslaeifplg
.... . .     ..   ..|                         ||||.|..|  | ....| |.. .|.. .                         
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgkn........................

knhsskvnsdsgipglaasVLVVSHGAYMRSLFDYFLTdlkCSLPATLSRSelmsvTPNTGMSLFIINfeEGREvkpTVQCICMNLQDHLNG
                   |||||||. .|.|. |.|    ..| ..|. .      ||.... . ..  ..     .|.....| ..||..
...................vlvVsHggvirallayllg...lpleellrln.....lpngsvtvleld..ddgk...rvvlvllndtshled
0039931 Phosphoglycerate mutase-like 6-263 3.4e-39 126.8 In-house 2-191 (219) alignment 
Range on Protein: 6-263
Range on HMM: 2-191/219.0
LTVVRHGETRFNKEKIIQGqgvDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGIlerskfckDMTVKYDSRLRERKYGVVEGKALSEL
| .|||||| .|.|...||   | ||.|.| .||.|.| .| .  ..|....||.|.|. ||.. |        ...|..|.||||. .|. ||. |.|.
lyLvRHGetewnvegrlqg...dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltleei

RA---MAKAAREEC-PVFTPPGGETLDQVKMRGIDFFEFLCQlilkeaDQkeqfsqgspsncletslaeifplgknhsskvnsdsgipglaaSVLVVSHG
..   .. ||. .  . ..|||||.| .|  | ....| |..      ..                                          .|||||||
aekypeelaawlrdpydyrppggEsladvvaRvlpaleella......ge..........................................nvlvVsHg

AYMRSLFDYFLtDLKCSLPATLsrselmsVTPNTGMSLFIINfeEgrevkPTVQCICMNLQDHL
. .| |. |.| .| ..  ..|         ||.... . ..  .      .......|| .||
gvirallayll.glsleeilrl.......nlpngsvtvleld..d.....ggwvlvllnltshl
0037864 Phosphoglycerate mutase-like 4-211 9.4e-38 122.1 In-house 8-176 (211) alignment 
Range on Protein: 4-211
Range on HMM: 8-176/211.0
FALTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGILERSKFCkDMTVKYDSRLRERKYGVVEGKALS
  | .|||||| .|.|...||. .| ||.|.| .||.|.| .| .  ..|....||.|.|. ||.. |||. ..   ..|..| ||||| .|. ||. |.
trlyLvRHGetewnaegrlqgw.ldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglp.llpvevdprlrErdfgalegltle

ELRAM----AKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQLILkeadqkeqfsqgspsncletslaeifplgkN--HsskvnsdsgipglaaSVLV
|....      |       |.|||||.| .|  | ....| |..  |                              .  .                |||
eiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarll..............................kdge...............nvlv

VSHGAYMRSLFDYFLT
||||. .|.|. |.| 
VsHggvlrallayllg
0048955 Phosphoglycerate mutase-like 6-216 1.6e-37 122.0 In-house 3-198 (240) alignment 
Range on Protein: 6-216
Range on HMM: 3-198/240.0
LTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGILERSKFCKdMTVKYDSRLRERKYGVVEGKALSEL
|..|||||. .|.|...||.  | ||.|.| .||.|.| .| .  .||....||.| |. ||.. |.|. .. . ..| .| ||||| .|. ||. |.|.
lyLvRHGesewnaegrlqgw.tDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpl.lpvvvdprlrErdfgalegltldei

RAMAKAAREECPVFTP-----------------------------PGGETLDQVKMRGIDFFEFLCQLilkeadqkeqfsqgspsncletslaeifplgk
... . . . .    .                             ||||.|..|  |  ...| |..                                 
aekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellar................................

nhsskvnsdsgIPGLAASVLVVSHGAYMRSLFDYFLTdLKCS
            .     |||||||. .|.|. |.|  |. .
...........alkpgknvlvVsHggvirallayllg.lple
0036887 Phosphoglycerate mutase-like 6-214 4.6e-37 119.9 In-house 4-163 (202) alignment 
Range on Protein: 6-214
Range on HMM: 4-163/202.0
LTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKfckdMTVKYDSRLRERKYGVVEGKALSELRA
| .|||||| .|.|...||. .| ||.|.| .||.|.| .| ...|....||.|.|. ||.. |.|. .    ..|..| ||||. .|. ||. |.|...
lyLvRHGetewnvegrlqgd.ldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealg....lpvivdprlrEidfgalegltleeiae

MAKAAREE----CPVFTPPGGETLDQVKMRGIDFFEFLCQLIlkeA--DqkeqfsqgspsncletslaeifplgknhsskvnsdsgipglaasVLVVSHG
.  ..        . |.|||||.| .|  | ....| |..     .  .                                            |||||||
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarl...dggn............................................vlvVsHg

AYMRSLFDYFLtdlK
. .| |. |.|   .
gvlrallayll...g
0035570 Phosphoglycerate mutase-like 6-264 5.1e-37 119.8 In-house 2-194 (219) alignment 
Range on Protein: 6-264
Range on HMM: 2-194/219.0
LTVVRHGETRFNKEKIIQGqgvDEPLSETGFKQAAAAGIFLNN--VKFTHAFSSDLMRTKQTMHGIlerskfckDMTVKYDSRLRERKYGVVEGKALSEL
| .|||||| .|.|...||   | ||.|.| .||.|.| .| .  ..|....||.|.|. ||.. |        ...|..| ||||. .|. ||. |.|.
lyLvRHGetewnlegrlqg...dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltldei

RAMAKAARE----ECPVFTPPGGETLDQVKMRGIDFFEflcqlilkeadqkeqfsqgspsncletslaeifplgknhsskvnsdsGIPGlAASVLVVSHG
...   .        . ..|||||.| .|  | ....|                                                ...   .|||||||
aekypeelaawlrdpydyrppggEsladvvaRvlpale...............................................eled.genvlvVsHg

AYMRSLFDYFLtDLKCSLPATLSrselmsvTPNTGMSLFIINFEEGrevkpTVQCICMNLQDHLN
. .| |. |.| .| ..  . |.        ||.... . .. ..|     .......|  .||.
gvirallayll.glpleeilrln.......lpngsvtvleldgggg.....kwvlvllndtshle
0053607 Phosphoglycerate mutase-like 6-211 1.9e-35 114.5 In-house 4-156 (191) alignment 
Range on Protein: 6-211
Range on HMM: 4-156/191.0
LTVVRHGETRFNKEKIIQGqgvDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGIlerskfckDMTVKYDSRLRERKYGVVEGKALSEL
|..|||||| .|.|...||   | ||.|.| .||.|.. .|   ..||....||.|.|. ||.. |        ...|..|.||||. .|. ||. |.||
lyLvRHGetewnaegrlqg...dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii........glpvevdprlrEidfgdwegltleel

RAM----AKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQlilkeaDQkeqfsqgspsncletslaeifplgknhsskvnsdsgipglaaSVLVVSHG
...      | ..    ..|||||.|..|  | ....| |..      ..                                          .||||.||
aekypeelaawlrdpldyrppggEsladvaaRvlpaleella......gg..........................................nvlvVaHg

AYMRSLFDYFLT
. .| |  |.| 
gvirallayllg
0050036 Phosphoglycerate mutase-like 6-210 8.6e-35 111.9 In-house 3-145 (171) alignment 
Range on Protein: 6-210
Range on HMM: 3-145/171.0
LTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFLnnvKFTHAFSSDLMRTKQTMHGILerskfckdMTVKYDSRLRERKYGVVEGKALSELRA
|..|||||| .|.|...||. .| ||.|.| .||.|.| .|   .|....||.|.|. ||.. ||        ..| .| ||||| .|. ||. |.|..|
lyLvRHGetewnlegrfqgw.tdvpLtelgraqaralgell...pfdavysSpllRArqTaelil........lpvivdprLrErdfGawegltldeiaa

MAKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCqlilkeadqkeqfsqgspsncletslaeifplgknhsskvnsdsgipglaASVLVVSHGAYMRSL
.        . ..|||||.| .|  | ....| |.                                                    ||||.||. .|.|
kypewlldlldlappggEsladvlaRvlpaleell..................................................gnvlvvaHggviral

FDYFL
. ..|
lalll
His_Phos_1 Histidine phosphatase superfamily (branch 1) 6-146 2.3e-30 98.6 Pfam-A 2-139 (158) alignment 
Range on Protein: 6-146
Range on HMM: 2-139/158.0
LTVVRHGETRFNKEKIIQGQGVDePLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGILERSKfckdMTVKYDSRLRERKYGVVEGKALSEL
|..|||||. .|||...||.  . ||.|.| .|| ..|  |   .........|.| |. ||....||. .    . .. . ||||| .|..||.  .|.
lylvRHGesewnkegrlqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeev

RAMAK----AAREECPVFTPPGGETLDQVKMRGIDFFEFLCQlilkE
... .    . ....  |.||.||.|..|  |  .|.| | .    .
keefpeeyekwkrdkkefrppegesladvyeRvapfleelie....a
His_Phos_1 Histidine phosphatase superfamily (branch 1) 6-146 2.3e-30 98.6 In-house 2-139 (158) alignment 
Range on Protein: 6-146
Range on HMM: 2-139/158.0
LTVVRHGETRFNKEKIIQGQGVDePLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGILERSKfckdMTVKYDSRLRERKYGVVEGKALSEL
|..|||||. .|||...||.  . ||.|.| .|| ..|  |   .........|.| |. ||....||. .    . .. . ||||| .|..||.  .|.
lylvRHGesewnkegrlqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeev

RAMAK----AAREECPVFTPPGGETLDQVKMRGIDFFEFLCQlilkE
... .    . ....  |.||.||.|..|  |  .|.| | .    .
keefpeeyekwkrdkkefrppegesladvyeRvapfleelie....a
subfamily_PGAM_pd Subfamily PGAM 6-207 4.5e-23 73.8 In-house 3-192 (248) alignment 
Range on Protein: 6-207
Range on HMM: 3-192/248.0
LTVVRHGETRFNKEKIIQGQgVDEPLSETGFKQAAAAGIFL--NNVKFTHAFSSDLMRTKQTMHGILERSKFCKdMTVKYDSRLRERKYGVVEGKALSEL
| ..||||. .|||....|  ||  |||.| ..| .||  |  .|..|  ...|.| |..||.. |||...  | . |....||.||.||...|   .| 
lvllRhGeselnkenkfcgw.vDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqek.iPvektwrLnErhyGaltglnkaev

raMAKAAREECPVF------TPPGGETLDQVkmrgidfF-EFLCQLILKeADQKEQFSQgspSNCLETSLAEIFPLGKNHSSK-VNSdsgipglAASVLV
  ..|  .|.  ..      .||  |. ...       | |   .   .   ..|.. .   | .|.  .. . |. ...  | ...         .||.
..akkyGeekvkiwRRsydvkPPpveedkey.......fkeinkdrrye.elkeeelPe...sEslkevveRllpvlneeilkeike.......gkrvli

VSHGAYMRSLFD
|.||  .|.|  
vahgnsvrallk
subfamily_PFKFB_pd Subfamily PFKFB 6-128 2.7e-10 32.0 In-house 9-126 (198) alignment 
Range on Protein: 6-128
Range on HMM: 9-126/198.0
LTVVRHGETRFNKEKIIqgqGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSDLMRTKQTMHGIlerskfckDMTVKYDSRLRERKYGVVEGKALSEL
. .|||||.  ||.. |   | |. |.| | ..| ... |..  |.|  . ..| | || || . .        .. ..  . |.|.  |...|   .|.
iylvRhGeseknkkgri...ggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaell........glpkeqwkaLdeldaGkcdgltyeei

RAM----AKAAREECPVFTPPGGETLDQV
. .     |. ...   . .|.||.  ..
kekfpeefkerkkdkyryryprgEsyedl
subfamily_STS_pd Subfamily STS 18-90 3.7e-10 31.6 In-house 42-114 (245) alignment 
Range on Protein: 18-90
Range on HMM: 42-114/245.0
KEKIIQGQGVDEPLSETGFKQAAAAG--IFLNNVKFTHAFSSDLMRTKQTMHGILERSKfcKDMTVKYDSRLRER
... ...   |.||.|.|. ||   |  .. ...|  |.|.|  .|. || . ||.  .  | ...| .  | | 
rpdglkdyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg..kkikikvepgllew
0053031 Phosphoglycerate mutase-like 4-70 7.7e-07 21.9 In-house 5-88 (342) alignment 
Range on Protein: 4-70
Range on HMM: 5-88/342.0
FALTVVRHG----ETRFNKEKIIQGQGVD--EPLSETGFKQAAAAGIFLN-----------NVKFTHAFSSDLMRTKQTMHGIL
..  .||||    .  .... ... .  .  ..|...|..|| . | .|            | .  ...|||  || |..  .|
qvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqafl
subfamily_TFC7_pd Subfamily TFC7 22-72 2.6e-06 18.2 In-house 24-76 (255) alignment 
Range on Protein: 22-72
Range on HMM: 24-76/255.0
IQGQGVDEPLSETGFKQAAAAGIFLNNVKFTH--AFSSDLMRTKQTMHGILER
..|   | |||| |..||   .|.|...   .  .||| | |  .| . | | 
ltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaee
SSXRD SSXRD motif 86-95 9.3e-06 11.5 Pfam-A 13-22 (34) alignment 
Range on Protein: 86-95
Range on HMM: 13-22/34.0
RLRERKYGVV
|||||||.|.
RLRERKyrVi