Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_PDP_pd | Subfamily PDP | 172-586 | 1.2e-174 | 574.1 | In-house | 1-398 (398) | alignment | ||
Range on Protein: 172-586
Range on HMM: 1-398/398.0
DSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSL
|||||..|.|||||||.|..|...|.|.||||||.|.||..|||.||..|.|.|||....| |.|.|.|||.|||..|...||..|..|.||.||....|
dsnqLasNePiEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslsel
RTYWQELIDLNTGestdiDVKEALINAFKRLDNDISLEAQVGDPNSFLNYlVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN
..|.|||...... .||||| .||..||.||| ||. ... |.. .|.||.|||.|..|...| .||||||||.||.||||||.|||.||.||.
skylqelleaeve.....kvkealkkaFlklDkdistealkklkekslre.allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLsk
DHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESgpdqlndnEYTKFIPP-NYHTPPYLTAEPEVTYHRLRPQDK
|..|.||.|.||.| |||..|.|.|....|||| |.|.||||||..||| .|||.|.|. .|.|...| .|.||||||||||||.|.||..||
dqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlek........aylkvlepkdyktPPYltaePevtshklrendk
FLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSvfEDQNAATHLIRHAVGNNEFGtvDHERLSKMLSLPEELA
||||||||||.......||..|||.|.......|..| .|.|| |.. |.||..|... ||.||||||||||.|.||.| |.|..|..||.|||||
FLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkr..edknaAthLirhalggneag..dkekvsallsiPeela
RMYRDDITIIVVQFNS
||||||||..||.|||
RmyRDDitvtVvffns
|
|||||||||
| PP2Cc_SM00332 | 161-582 | 2.7e-70 | 229.9 | In-house | 4-274 (274) | alignment | |||
Range on Protein: 161-582
Range on HMM: 4-274/274.0
DGKNVSSILGFdSNQLPANAPIEDRRSAATCLQ--TRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLeienavesgrallpilqwhkhpndy
.|.| . . |. |.. ... ..||. ..|. ..... ||||||.| .... ||..|. ... .| ... |
sgsnlglsygk.ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.........................
fskeasklyfnslrtywqelidlntgestDIDVKEALINAFKRLDNDISLEAQVGDPNSflnylvlrvAFSGATACVAHVDGVDLHVANTGDSRAMLGVQ
. ||.||| .||...|..| |.|. .. | ||.||.||.... ||.|||.|||||.|. .
.............................eddveealkkaflstdeeileeeqskelen.........alsGstavvallkkedlyvanvGDSravlcrn
EEdgswsAVTLSNDHNAQNERELERLKLEHPkseaksVVKQDRLLGLLMPFRAFGDVKFKWSIdlqkrviesgpdqlndneytkfippnYHTPPYLTAEP
.. || ||.||....|.|..|.| ... ||...|. | |. |||||...|... ....||.||||
gk.....avqlsvdhkpedederkRikkagg......vvekgrvngglavsrafGdhflkknk..........................klkepyitaep
EVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMhhqqpiavggykvtlgqmhgllterrtkmsSVFEDQNAATHLIRHAVGNnefgtvdher
.|....|...|.||.||.||||. .. |.|| || . |. . . . |.||..|...| .
dvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg..............................ktndpqeaaelldeeairr..........
lskmlslpeelaRMYRDDITIIVV
....|.||..||
............ggseDniTvvvv
|
|||||||||
| 0034914 | PP2C-like | 177-585 | 5.3e-56 | 182.6 | In-house | 31-291 (295) | alignment | ||
Range on Protein: 177-585
Range on HMM: 31-291/295.0
PaNAPIEDRRSAATCL---QTRGMLLGVFDGHAGCACSQAVSERLFYYIAvsllphetlleI-----------Enavesgrallpilqwhkhpndyfske
. . ||. .. ..| .. ..|.|||||| |.|... .||.|..... .
r.rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelll...........ellekllllltls..........................
asklyfnslrtywqelidlntgestDIDVKEALINAFKRLDNDISLEAQVGdpnsflnylvLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGvqeEDG
. |..|||..||...|... .|. ..|.||.||.||.. | |.|||.|||||.| .|
.........................ledieealrkaflaadeellelallr..........pelagsGtTavvalirgnklyvanvGDSravll...rng
swSAVTLSNDHNAQNERELERLKLEHPkseaksVVKQDRLLGLLMPFRAFGDVKFKWSidlqkrviesgpdqlndneytkfiPPNYHTPPYLTAEPEVTY
.| |..||. || | ||.. ... .| .|..|.|. ||.||. .|.. .......|...|||.||.
..elvqltvdhkpvnelererilsagg......avshgrvngvlavtRalGdfdlkll........................lslllleplvsaePdvtv
HRLR-PQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHqqpiavggykvtlgqmhgllterrtkmssvfeDQNAATHLIRHAVGnnefgtvdherlsk
..| ..|.||.||.||||... ...|.|| ..|.. .. ..||..|...|.
leltledddfllLasDGlwdvlsneeivdivrsllakgld................................leeaaeeLvdlAla..............
mlslpeelaRMYRDDITIIVVQFN
|..||.||..||..|
.........rgsrDNiTvvvvrln
|
|||||||||
| PPM_PTC7 | 261-494 | 1.5e-37 | 122.5 | In-house | 46-232 (259) | alignment | |||
Range on Protein: 261-494
Range on HMM: 46-232/259.0
KEASKLYFNSLRTYWQELIDLNTGEstdiDVKEALINAFKRLDNDISLEAqvgD-PNsflnylVlRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQE
||.|. ..| . ..| ......| ....||...| .|| |..|. . | ||.|| || . | .|.|||.|||||.|. ..
reaakyarehleeilkerksfeele....klekalrksflaldtdeelks...sean......t.epstsGstAvvalitgsklyvAnvGDSravLcrsg
EDGswsaVTLSNDHNAQNERELERLKLEHPKSEAKsvvKQDRLLGLLMPFRAFGDVKFKWSIDlqkrviesgpdqlndneytkfippnyhTPPYLTAEPE
.. ..|..||...||.| ||.. .. . . . .. |. | | |||||...| ......|||.
nav....kqltedHkpsnedEreRiegaggsvsnv...gngrvngvlavsRafGdfelkpket...........................eeqlvsaePd
VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGE
.. . . ..|.||.||.||||. . |..| .| .
isstkideedefliLasdGlwdvvsdqeavdlvrs
|
|||||||||
| PP2C | Protein phosphatase 2C | 261-500 | 2.2e-37 | 122.0 | Pfam-A | 46-233 (255) | alignment | ||
Range on Protein: 261-500
Range on HMM: 46-233/255.0
KEASKLYFNSLRTYWQELIDLNTGEstdiDVKEALINAFKRlDNDISLEAqvgDP-NsflnylVlRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQE
||.|. ..|.. ..| ......| .|..||...| . | | .|. . | ||.|| || . | .|.|||.|||||.|. .
reaakyarehleeilkeqksflele....kvekalrksfla.dtdeelks...skan......t.epsksGstavvalirgkklyvAnvGDSravLcrkd
EDGswsaVTLSNDHNAQNERELERLKLEHPKSEAksvvkQDRLLGLLMPFRAFGDVKFKWSIdlqkrviesgpdqlndneytkfippnyhtPPYLTAEPE
.. ..|..|| ...|.| ||.. .. . . . |. | | ||.||...| ... .|||.
nak....keltedHkpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.............................eqlvsaePd
VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH
|| ..| ..|.||.||.||||. . |..| .| . |. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk
|
|||||||||
| PP2C | Protein phosphatase 2C | 261-500 | 2.2e-37 | 122.0 | In-house | 46-233 (255) | alignment | ||
Range on Protein: 261-500
Range on HMM: 46-233/255.0
KEASKLYFNSLRTYWQELIDLNTGEstdiDVKEALINAFKRlDNDISLEAqvgDP-NsflnylVlRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQE
||.|. ..|.. ..| ......| .|..||...| . | | .|. . | ||.|| || . | .|.|||.|||||.|. .
reaakyarehleeilkeqksflele....kvekalrksfla.dtdeelks...skan......t.epsksGstavvalirgkklyvAnvGDSravLcrkd
EDGswsaVTLSNDHNAQNERELERLKLEHPKSEAksvvkQDRLLGLLMPFRAFGDVKFKWSIdlqkrviesgpdqlndneytkfippnyhtPPYLTAEPE
.. ..|..|| ...|.| ||.. .. . . . |. | | ||.||...| ... .|||.
nak....keltedHkpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.............................eqlvsaePd
VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH
|| ..| ..|.||.||.||||. . |..| .| . |. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk
|
|||||||||
| 0049733 | PP2C-like | 183-585 | 9.3e-34 | 109.9 | In-house | 19-234 (235) | alignment | ||
Range on Protein: 183-585
Range on HMM: 19-234/235.0
EDRRSAatclqtRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPhE-TLLeienavesgrallpilqwhkhpndyfskeasklyfnslrtywqelidl
||. . ..|..|.||| |.|... .||.|. ... ||. .|
eDavlv......glllfavaDGhgghaagevasellvetllellle.lllld................................................
ntgestdidVKEALINAFKRLDNDISLEAQVGDpnsflnylvlRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVqeedgSWSAVTLSNDHNAQNEREL
..|||..||..... . .|. .| .|.||.|| .|| |.||| |||||.| . .| |. ||. || |
.........leealrkaflaaneallelalasp..........elagmgtTavvalldggklyvanvGDsrayllr.....dgklvqltedhspvneler
ERLKLEHPKSeaksvvkqdRLLGLLMPFRAFGDVKFKwsidlqkrviesgpdqlndneytkfippnyhtppyltaePEVTYHRLRPQDkFLVLATDGLWE
.|.. ... | .| |. ||.|| .| |.||...|.|.| ||.||.||||.
qriitaggav.........rvpgrlaltralGdlllk.......................................pdvtvlelepgd.flllasDGlwd
TMHRQDVVRIVGEylTGMhhqqpiavggykvtlgqmhgllterrtkmssvfedQNAATHLIRHAVGnnefgtvdherlskmlslpeelaRMYRDDITIIV
. ...|... . . . ..|| .|...|. | ||.||..|
vlsdeeivdllrs..ldl...................................eeaaerlvelala.......................rggrDNiTvvv
VQFN
|...
vrld
|
|||||||||
| subfamily_PPM1G2_pd | Subfamily PPM1G2 | 197-499 | 1.9e-28 | 92.2 | In-house | 53-250 (287) | alignment | ||
Range on Protein: 197-499
Range on HMM: 53-250/287.0
MLLGVFDGHAGCACSQAVSERLFYYIAVsllphetlleienavesgrallpilqwhkhpndyfskeasklyfnslrtywqelidlnTGESTDIDVKEALI
|..||||| | .... ....| .|| . .. ....|.
alfavfDGhGGakvakyagkklikkiak..........................................................kksfkegaleqilk
NAFKRLDNDISLEaqvgdpnsflnyLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEdgswsAVTLSNDHNAQNERELERLKlehpksEAKSV
.||...|... . |. .|.|| |. . .| |||.|||||.| .. . . .|| || |.| | .|.. .| .
dafletDeellkd............eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkrii......aagGf
VKQDRLLGLLMPFRAFGDVKFKWSIDlqkrviesgpdqlndneytkfIPPNYHtppYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL
|. .| | | ||.|| .|| . ..|. . ||.|.|. ..|...| ||||| ||.|. .. ..|| .| | |
velnrvngnLalsralgDfefkknvk.....................kkpeeq...ivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerl
TGM
.
vsg
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 329-497 | 2.3e-22 | 72.6 | In-house | 296-430 (473) | alignment | ||
Range on Protein: 329-497
Range on HMM: 296-430/473.0
SGATACVAHVDGVDLHVANTGDSRAMLGVQeedgsWSAVTLSNDHNAQNERELERLKlehpksEA-KSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRv
||.||.|| . . .| ||| ||||..| . |. || || ..| ||||.. .| | .. |. | | ||.|| .| .|...
sGttAvvaLlkekklivAnaGDsRcvlsrn.....GkAldlslDHkPeDevEleRie......kAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplk.
iesgpDQLndneytkfippnyhtppyLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLT
.|. ..| |.. . | ..|.|||||.||.| .|. |.|| | . |.
.....eqm..................isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklk
|
|||||||||
| subfamily_PPM1A_pd | Subfamily PPM1A | 178-432 | 9.9e-20 | 64.0 | In-house | 22-209 (282) | alignment | ||
Range on Protein: 178-432
Range on HMM: 22-209/282.0
ANAPIEDRRSAATCLQTR--GMLLGVFDGHAGCACSQAVSERLFYYIAVsllphetlleienavesgrallpilqwhkhpndyfskeasklyfnslrtyW
. ||. .....|... . . ||||||| ... |.. | |
wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..................................................e
QELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDP--NSflnylvlrvafsGATACVAHVDGVDLHVANTGDSRAMLGVQEedgswSAVTLSNDH
.|| . .. .|.. .||||| ..| .||..|. . . . .| |.|| .. | | .|| |||||.| .. .|. |..||
eelkeaaleasekdevkealrqgfLaldeairelstdlktadks............GsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDH
NAQNERELERLKlehpksEAKSVVKQDRLLGLLMPFRAFGDVKFKW--SIDLQKRVIESGP
.....| .|.. .| | .|. | | ||.|| ..| . . ... . . |
kpsrpkEkkRie......qAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaep
|
|||||||||
| PPM_PTC7_SpoIIE | 270-492 | 1.5e-19 | 63.7 | In-house | 53-205 (230) | alignment | |||
Range on Protein: 270-492
Range on HMM: 53-205/230.0
SLRTYWQELIdLNTGEstdiDVKEALINAFKRLDNDISLEaqvgdpnsflnylvlrVAFSGATACVAHVDGVD--LHVANTGDSRAMLGVQeEDGswsav
||| ..||. ...| ...|.|.... .|. |. | .. |||||.||..|. . |.||| |||...| . ..|
llrtalrela.fagle....kpeeilrrlnlalaadlede................psssgaTavvalidpstgklyvanaGdsppllvrd.dgg.....
tlsndhnaqnerelERLKLeHPKSEAKsV-VKQDRLLGLLMPFRAFGDVKFKWsidlqkrviesgpdqlndneytkfippnyhTPPYLTAEPEvTYHRLR
|| . . . . . .| | | .|.||. .. | . .|||. | . .
..............ereri.vagglps.lGilpgrvfgvlavslapGdlllly..............................tDGvveaepd.tsdgel
PQ-DKFLVLATDGLWETMHRQDVVRIV
.. |.||.||.||||. . |..|..|
fgkdeflilasdglwdvlspqelvdlv
|
|||||||||
| subfamily_TAB1_pd | Subfamily TAB1 | 329-418 | 1.8e-14 | 46.3 | In-house | 129-213 (333) | alignment | ||
Range on Protein: 329-418
Range on HMM: 129-213/333.0
SGATACVAHVDGVDLHVANTGDSRAMLGVQEEdgSWSAVTLSNDHNAQNERELERLKLEHPKSEaksVVKQDRLLGLLMPFRAFGDVKFK
|.|| || . .|.||| |||||.| ..| | . || ||. .|| ||.||| | .|. ..|| .. |. || | |
gGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLGldie...qikrnkrlgskentRsiGdykvk
|
|||||||||
| subfamily_ILKAP_pd | Subfamily ILKAP | 285-419 | 8.1e-14 | 44.4 | In-house | 79-198 (293) | alignment | ||
Range on Protein: 285-419
Range on HMM: 79-198/293.0
ESTDIDVKEALINAFKRLDNDISLEAQVGDPNsflnYlvlRvafSGATA-CVAHVDGVdLHVANTGDSRAMLGVQEEDGS-WSAVTLSNDHNAQNERELE
... ..| .|...||. |.. .|. . | . . |.|| .| .| | |.||| |||.|.| ..|.|. ..|.|. ||.. .. | .
sakekeikkclvdsfkktdeefLklaskakPv....W...k...dGstatvvlvldnv.lyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerk
RLKlehpksEAKSVVKQDRLLGLLMPFRAFGDVKFKW
|.. | .||...|.||.| |. || .||
riq......kaGgvvrdgrvlGvlevsrsiGdgrfkr
|
|||||||||
| subfamily_PPM1K_pd | Subfamily PPM1K | 288-418 | 2.9e-13 | 42.5 | In-house | 64-182 (263) | alignment | ||
Range on Protein: 288-418
Range on HMM: 64-182/263.0
DIDVKEALINAFKRLDNDISLEAQVGDPNSflnylvlRVAFSGATACVAHV-DGVDLHVANTGDSRAMLGVQeedGSwsAVTLSNDHNAQNERELERLKL
. |... | |||. ||.... .. ... ||.|| |. . ||..| .|..|||||.| . | | |..||. . | | ||.|
ekdleivlknafeeldkklkrylefsvaea.......ellssGttatvsllrdGtelvlaslGdsrailcrn...Gk..akkltrdhdPeleeekerika
EHPKSEAKSVvKQDRLLGLLMPFRAFGDVKFK
. | .|. . .. | | |..||...|
agGsvewnsl.gkplvngrlamtrslGdldlk
|
|||||||||
| subfamily_PPM1L_pd | Subfamily PPM1L | 183-418 | 3.7e-12 | 39.1 | In-house | 20-188 (269) | alignment | ||
Range on Protein: 183-418
Range on HMM: 20-188/269.0
EDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAvesgrallpilqwhkhpndyfskeasklyfnslrtywqelid
||| .. . .| ...||||| | .. . ..| | |. .. | .
edrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentep..........................................
lntgestdidvkealINAFKRLDNDIsLEAQvgdpNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLgvqeEDGSWSAVTLSNDHNAQNERE
|| | | ..| | .. . .|. . .|.|| .| |.. || ||| |||| .| | . |. || || |. .|
...............infsklltdei.lsvd....ekllekakraediaGttalialvqesdlivanvGdsrGvl....ydkrGkaiplsfdhkpqqvke
LERLKLEHPkseAKSVVKQDRLLGLLMPFRAFGDVKFK
|.| . |. |.| ||.|| .|
rkrikkaGG...fiafrGvwrvaGvlatsralGdyplk
|
|||||||||
| subfamily_PPM1H_pd | Subfamily PPM1H | 193-385 | 1.1e-10 | 33.8 | In-house | 59-214 (404) | alignment | ||
Range on Protein: 193-385
Range on HMM: 59-214/404.0
QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAvesgrallpilqwhkhPNDYFSKEASKLYFNSLRTYWqelidLNTGESTDIDVK
. .. |.|||||| . . . |. | . | || ..| .. . .| || .| .. . . |.. |.
klplayfglfDGhaGsgaalvaskllhkhlkekledvlellleksa................eeeenteesskespssvseiy.....eekeiskeeLvi
EALINAFKRLDNDISLEAQVgdpnsflnYLvlrvAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDgswsaVTLSNDHNAQNERE-LERLK
|| .||...|. |. | . | | ||.|| | |.||| |||||.| ..| . ||.|. . ||. | .|
GalesaflemDeqiarerea........yr....ikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPeteRqRlqela
|
|||||||||
| subfamily_PPM1D_pd | Subfamily PPM1D | 286-385 | 1.4e-10 | 33.8 | In-house | 70-165 (309) | alignment | ||
Range on Protein: 286-385
Range on HMM: 70-165/309.0
STDIDVKEALINAFKRLDNDISLEAQvgdpnSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEE-DGSWSAVTLSNDHNAQNERELERL
| . || ||. .|| . . . . . .. . .. .|.|| | . . .|.||. |||...|||.|. . .. | .| .|| .. .| ||.
sepedvleAireaflatheamkkkle.....eWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekeri
K
.
e
|
|||||||||
| subfamily_PPM1A_pd | Subfamily PPM1A | 454-584 | 3e-09 | 29.6 | In-house | 205-280 (282) | alignment | ||
Range on Protein: 454-584
Range on HMM: 205-280/282.0
LTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIavggykvtlgqmhgllterrtkmssvfedqnaathlirhavgnnefgt
..|||||| . .|.||||| ||.|... ..|| .| . |. .. . .
vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev................................................
vdherlSKMLsLPEELARMYRDDITIIVVQF
.| | . . | . || ....|| |
......akal.vdkalekgsrDNlsvlvvlf
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 450-500 | 8.5e-09 | 28.0 | In-house | 182-232 (265) | alignment | ||
Range on Protein: 450-500
Range on HMM: 182-232/265.0
TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH
. ||...|..|. .| ....|.||.||||.......||..| |.|. .
lkpyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladga
|
|||||||||
| subfamily_PPM1H_pd | Subfamily PPM1H | 450-502 | 1.7e-08 | 26.6 | In-house | 301-357 (404) | alignment | ||
Range on Protein: 450-502
Range on HMM: 301-357/404.0
TPPYLTAEPEVTYHRLR----PQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQ
|.|...|||. |. .|. |.|||||||. . ..| .|| | |. ....
ikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepe
|
|||||||||
| PP2C_SIG_SM00331 | 260-503 | 2.6e-08 | 26.7 | In-house | 45-188 (217) | alignment | |||
Range on Protein: 260-503
Range on HMM: 45-188/217.0
SKEASKLYFNSLRTYWQELidlntgestdidvkEALINAFKRLDNDISLEaqvgdpnsflnylvLRVAFSGATACVAHV--DGVDLHVANTGDSRAMLGV
. .||. . ||....| |.| .|.|||. | | . ..||...|.. . |..|| |||| |
Aaaassqlrtalrellseg..............eelsqalkrlnraiyee..............keekgmfaTlllalydfssgklsyanaGdsrpyllr
qeEDGSWSAVTLsndhnaqnerelerlklehpkseaksvvkqdrllgllmpfrafgdvkfkwsidlqkrviesgpdqlndneytkfippnyHTPPYLTAE
... .. ... | |
..dgklveilkd...............................................................................vegaplGle
PEV----TYHRLRPqDKFLVLATDGLWETM-----HRQDVVRIVGEYLtGMHHQQ
||| . | . . .|.|.||||.| . .... .|. ... ....|.
pevsvdirelelek.gdllllytDGltearsekgfaeerleeiledlv.dseaqe
|
|||||||||
| subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 325-415 | 7.2e-08 | 25.0 | In-house | 91-175 (255) | alignment | ||
Range on Protein: 325-415
Range on HMM: 91-175/255.0
RVAFSGATACVAHVDGVDLHVANTGDSRAMLGvqEEDGswSAVTLSNDHNAQNERELERLKLEhpKSEAKSVVKQDRLLGLLMPFRAFGDV
| | |.|| .. . . .|| ||||..|. . || |. || ||. ..|.| .|.. | |. |. | | ||.||.
rpkfiGttaasvliiedkvyianvGdsrvvlc..qkdg..takrlsldhkPseeseekrisel..GGtvvstvvtsrvnGtlavsralGds
|
|||||||||
| subfamily_PPM1D_pd | Subfamily PPM1D | 456-496 | 9.4e-08 | 24.5 | In-house | 224-265 (309) | alignment | ||
Range on Protein: 456-496
Range on HMM: 224-265/309.0
AEPEVTYHRLRPQDK-FLVLATDGLWETMHRQDVVRIVGEYL
||.|. ..| |... |..||.||||. . .|.|..| ..
PePdvkvrtldpneekfiilasDGlwnvltpedavsvvekee
|
|||||||||
| subfamily_ILKAP_pd | Subfamily ILKAP | 454-503 | 1.1e-07 | 24.3 | In-house | 201-250 (293) | alignment | ||
Range on Protein: 454-503
Range on HMM: 201-250/293.0
LTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQ
... |.|. .| . |.|.||| ||||.... ..||. . . | ....
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 328-419 | 1.2e-07 | 24.2 | In-house | 101-184 (265) | alignment | ||
Range on Protein: 328-419
Range on HMM: 101-184/265.0
FSGATACVAHVDGVDLHVANTGDSRAMLGVQEEdgswsAVTLSNDHNAQNERELERLklEHPKSeAKSVVKQDRLLGLLMPFRAFGDVKFKW
||.|| |. ... |.|| |||.|.| . | ||.| . |. ..|.| .|. |. |. . | | | || |||| |
ksGstavvvliekdqlyvaWlGDsqallvrkge.....avqlmkpHkPeredEkkRi..eeagG.lvvvigawRvnGvLsvsRaiGDvklkp
|
|||||||||
| subfamily_PP2D1_pd | Subfamily PP2D1 | 456-562 | 7e-07 | 21.3 | In-house | 266-371 (492) | alignment | ||
Range on Protein: 456-562
Range on HMM: 266-371/492.0
AEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH-HQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNaaTHLIRHAVGNNEFGTV
||..| | ...|||||. |||| . ..|. .| . |. .. . . | . .|| ..| .|.| .|.. . . .. . . .
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpdsdvttvgedylgEleakklsaryentg..fdkfvtseidldaaeg
DHERLSKM
|. | |.
desnlqkl
|
|||||||||
| Rod_C | Rough deal protein C-terminal region | 217-301 | 1.8e-06 | 12.8 | Pfam-A | 12-95 (551) | alignment | ||
Range on Protein: 217-301
Range on HMM: 12-95/551.0
RLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELidlNTGESTDIDVKE--ALINAFKR
|| . . . | ..|. | .||. . ||.. . | .|.. ..|.| .. |. .| . ||. . || ..... ..
RlPFhlllteqplkkilseelsvenfktllllvklmkvslDklymsavknvikelkpkllek...kkkeswhlqskevnkvlqsils
|
|||||||||
| subfamily_KAPP-like_pd | Subfamily KAPP-like | 261-388 | 3.1e-06 | 19.4 | In-house | 50-158 (266) | alignment | ||
Range on Protein: 261-388
Range on HMM: 50-158/266.0
KEASKLYFNSLRTYWQElIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFlnYLVLRVAfsgatacvahvDGVDLHVANTGDSRAMLGVQEE
. |.||. . | . .. . . | | .. | |||| .|. .. | . || . . | ||| ||| |.| .|
daakklfpkelekllks.tkqddGGdniydqskllenafkevdaklkdfeyeGatatl..alvwsdG...........qqrylqvanvGdssaflsrGne
dgswsAVTLSNDHNAQNERELERLKLEH
.. || ||.|....| |.| .
.....slelskdhkakdpeekqrikddG
|
|||||||||
| subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 451-493 | 3.3e-06 | 19.6 | In-house | 178-221 (255) | alignment | ||
Range on Protein: 451-493
Range on HMM: 178-221/255.0
PPYLTAEPEVT-YHRLRPQDKFLVLATDGLWETMHRQDVVRIVG
|.....|... . .||||.|| ||.|. . .. | ||
ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva
|
|||||||||
| subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 466-503 | 4.8e-06 | 18.6 | In-house | 233-270 (305) | alignment | ||
Range on Protein: 466-503
Range on HMM: 233-270/305.0
RPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQ
...|.||||||||||| .. |||| | | | .|.
kanDqflvlatdGlwevlsyqdvveevkellrdkssqk
|
|||||||||