Gene PPM1A in Homo sapiens

Synonym: PP2C-ALPHA, PP2CA, PP2Calpha, PPM1A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP174_AA protein Get Run
HsapP174_AA_75-367 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 81-366 2.2e-131 430.4 In-house 3-282 (282) alignment 
Range on Protein: 81-366
Range on HMM: 3-282/282.0
PkmekhNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPsGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFK-GSAGAPSVENVKNGIRTGFL
|     ..|..|||||||.|||||||||||||||.|. |. .|..||||||.||||||.||||. .|||..|......|  .. | . ..||...|.|||
p.....ksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfL

EIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVH
..||..| .|.....||.||||||.||.|..|....|.||||..||||.|..| |.|||||.| ||.||..|||||...||||.|||||||||..||. .
aldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeee

GKGPTEQLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPN
 |...|||||.||||. |||||||| |..|||||||||. .||....||.||||.|.||.|....||..| ||||||.||....|..
ekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak
PPM_PTC7 96-357 5.3e-94 307.5 In-house 2-259 (259) alignment 
Range on Protein: 96-357
Range on HMM: 2-259/259.0
RYGLSSMQGWRVEMEDAHTAVIGLP--SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAgapsveNVKNGIRTGFLEIDEHMRVMSEKKH
..| |..||.|..|||||.|  .|   || .|..||||.|||.|...|||..||| ... ....|. ..      ......|..||..|  .. .|....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelkssean

-GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH-FFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAVSRALGDFDYKCVHGkgpTEQLV
 . ..|||||| .||.... |. |.|||| .|||..... ..|.||||||. |.|||..|||||.    .||||.||||||.|||..|. .    .||||
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlv

SPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTdDLEKVCNEVVDTCLYKGSRDNM
|.||... ....|| |.|.|||.||.|||. ..|..|.|||.|. . |........||... .||.||.
saePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 96-357 3.9e-92 301.4 Pfam-A 2-255 (255) alignment 
Range on Protein: 96-357
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHTAVIGLP--SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAgapsveNVKNGIRTGFLE-IDEHMRVMSEKK
..| |..||.| .|||||.|   |   || .|..||||.|||.|...|||. ||| ... ....|....      .|....| .||. .||... .....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskant

hGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH-FFTQDHKPSNPLEKERIQNAGGSVM-IQRVNGSLAVSRALGDFDYKCVHgkgptEQLVSP
   ..|||||| .||.... |. |.|||| .|||... . ..|.|||||.. |.|||..|||||. ..|||||||||||||||..|. .     |||||.
.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsa

EPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNM
||.|. ....|| |.|.|||.||.|||. ..|..|.|||.|. .........|.|| .. .||.||.
ePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 96-357 3.9e-92 301.4 In-house 2-255 (255) alignment 
Range on Protein: 96-357
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHTAVIGLP--SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAgapsveNVKNGIRTGFLE-IDEHMRVMSEKK
..| |..||.| .|||||.|   |   || .|..||||.|||.|...|||. ||| ... ....|....      .|....| .||. .||... .....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskant

hGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH-FFTQDHKPSNPLEKERIQNAGGSVM-IQRVNGSLAVSRALGDFDYKCVHgkgptEQLVSP
   ..|||||| .||.... |. |.|||| .|||... . ..|.|||||.. |.|||..|||||. ..|||||||||||||||..|. .     |||||.
.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsa

EPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNM
||.|. ....|| |.|.|||.||.|||. ..|..|.|||.|. .........|.|| .. .||.||.
ePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
0034914 PP2C-like 76-367 4.8e-92 300.7 In-house 2-293 (295) alignment 
Range on Protein: 76-367
Range on HMM: 2-293/295.0
AFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIR
..|..|..|...   . . ||.| .|.||.| ..|||...|..|.|.||....|.|.||| |...|....|.|.... ..         .| |.... .|
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

TGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDY
..||..||... ......  ..||.||| .|| ... |. |.|||| .|.|| .... | ||||.|.||.|||..||| |.  ||||.|||.|||||||.
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNA
|...   ..|.|||.||.|. .|.. |||.|..||.||.|||. |||..|.|||.|. ..|||....|.|| .| .|||||..|....... 
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1G2_pd Subfamily PPM1G2 78-364 1.2e-86 283.2 In-house 2-286 (287) alignment 
Range on Protein: 78-364
Range on HMM: 2-286/287.0
LDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTA---VIGLPSGlESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKgsagapsVENVKNGI
|..| ..|..| .. .  . | |.|||.|..|||||.    .. ..   .| ..|||.||| |..||||. ..|   |.....||        ..... .
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksdd.kslalfavfDGhGGakvakyagkklikkiakkksfk.......egaleqil

RTGFLEIDEHMRVMseKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFD
. .|||.||...    .|   . .||||| |||. .. |  |.|||| .|. . .|. .. ||||..  ||.||..||| | ..||||.||.||||||| 
kdafletDeellkd..eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfe

YKCVHGKGPTEQLVSPEPEVHDIERSeEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSR------DNMSVILICF
.|  . |.| ||.|  .|.|   ... ||| |..|||||||||. |.|..|.||.||    .|.....|..|.|| . |.      |||.|.....
fkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2Cc_SM00332 87-362 1.1e-84 277.1 In-house 2-274 (274) alignment 
Range on Protein: 87-362
Range on HMM: 2-274/274.0
NAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPsGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGapsVENVKNGIRTGFLEIDEHMR
. .|...||.||.|||||||..|||||  |. |    |.|.||.|.|||.||.|||.....| ... ..  .| .      ..|.. ....||..|| ..
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeil

VMSEKKHGA-DRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHgkGPTE
 . ..|     .|||||| .|.. .. |. |.||||  ||||.|..  ..||||... |..||..|||.|. .||||.||||||.||...|     ...|
eeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klke

QLVSPEPEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRL--EVTDDLEKVCNEVVDTCLYK-GSRDNMSVILI
. ...||.|. ..   ..|.|.|||.||.|||. |.|..|.||..|  ..| | ......... .. . ||.||..|...
pyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 95-365 2.5e-63 206.4 In-house 3-234 (235) alignment 
Range on Protein: 95-365
Range on HMM: 3-234/235.0
LRYGLSSMQGW-RVEMEDAHTAviglpsgleSWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQ-DfkgsagaPSVENVKNGIRTGFLEIDEHMRVMSEKK
|..| .|..|. | ..|||. .         ....|||.||| |....... |.|.... .   .       .. ..... .|  ||...| .. .... 
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle.......lllldleealrkaflaaneallelalas

HGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVmiqRVNGSLAVSRALGDFDYKcvhgkgpteqlvspeP
.. ...|.||| .|. ... |..|.|||| .|.|. |... |.||.|.|.||..||..||| |   ||.|.||..|||||...|               |
pelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............p

EVHDIERSEEDdqFIILACDGIWDVMGNEELCDFVRSrlevtDDLEKVCNEVVDTCLYKGSRDNMSVILICFP
.|. .| ...|  |..||.||.|||. .||..|..||     .|||......|...| .|.|||..|......
dvtvlelepgd..flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1E_pd Subfamily PPM1E 100-364 3.2e-55 180.1 In-house 9-262 (265) alignment 
Range on Protein: 100-364
Range on HMM: 9-262/265.0
SSMQGWRVEMEDAHTAVIGLPSGL-----ESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGapsvenvkNGIRTGFLEIDEHMRVMSEKKhg
 .... |  ||| | |.  | . .     .  .||||.|||.|.. |||  .||  .. .....| ..         . .. .| ..||..   .|..  
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqkaere..

ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpteQLVSPE
. .|||||| |||. .. |    |||..||.|....  ... |||... ||.||..||| |.     ||||.|.||||.|| ..|         . || |
klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsge

PEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD-DLEKVCNEVVDTCLYKGSRDNMSVILICF
..| ..|  .......||||||.|||. .||... |.. |. .  ||..| ...|..   .||.||..|... .
advaevel.dgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
PPM_PTC7_SpoIIE 96-347 3.5e-51 167.2 In-house 2-220 (230) alignment 
Range on Protein: 96-347
Range on HMM: 2-220/230.0
RYGLSSMQGWRVEMEDAHTAVIGLP--SGLESWSFFAVYDGHAGSQvaKYCCEHLLDHITNNQdFKGSAgapsveNVKNGIRTGFLEIDEHMRVMsekkh
..| |..||.| .|||||..  ..   ||  .. .....||| |..  ... ..| . . ..  |.|.       .... .| ..|... ... .     
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle......kpeeilrrlnlalaadlede.....

gADRSGSTAVGVLISPQH--TYFINCGDSRGLLCRNRKVhfftqdhkpsnplEKERIqNAGGSVM----IQRVNGSLAVSRALGDFDYKCvhgkgpTEQL
  . ||.||| .|| |..   |..|.|||. ||.|. .              |.|||  ||| ..     .||.|.||||.| ||. ...      |...
.psssgaTavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGv

VSPEPEvHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTddlekVCNEVVDT
|..||. .. .. ...|.|.|||.||.|||. ..||.|.||..||       .... .. 
veaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleD
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 94-365 5.5e-50 163.0 In-house 5-254 (255) alignment 
Range on Protein: 94-365
Range on HMM: 5-254/255.0
GLRYGLSSMQGWRVEMEDAHTaVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSagaPSVENVKNgirtGFLEIDEHMrvmSEKKh
 .. | | | | |  |||  . . |   . .   ..|..|||.|.. ||...|.|   ...  | . .   . |. .|.     . ||.  .   ||.  
rfkvgfsdmiGrrptmedelv.iyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna...nPvkslkk....aykeistqi...serp.

gaDRSGSTAVGVLISPQHTYFINCGDSRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ----RVNGSLAVSRALGDFdYkcvhgkgpTEQLV
   . |.||. |||  ...|  | |||| .|| ..   .  . |||||.. |..||...|| |. .    |||| |||||||||  .         |  |
..kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfv

SPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSrlevTDDLEKVCNEVVDTCLYKGSRDNMSVILICFP
 |.|....  .  ..|.|.|||||||||.. .|| .. | .      | || .... |    .|| ||.|||.| ..
vpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls
subfamily_PPM1G_pd Subfamily PPM1G 188-365 3.3e-49 161.1 In-house 286-471 (473) alignment 
Range on Protein: 188-365
Range on HMM: 286-471/473.0
MSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM-IQRVNGSLAVSRALGDFDYKCVHGKGPTEQ
. || .    ||.||| .|.  .. .  | ||||  |.|| |   .  |||| .. |.|||..||| |    |||| | .||||||. ||  .  .. ||
seekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeq

LVSPEPEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD--DLEKVCNEVVDTCLYKGS------RDNMSVILICFP
..|  |...  .   |.|.|..|||||||.||  .|  ||||..|. ..   |.....|..|.|| .         |||.||.... 
misAlPDikvltl.teedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllk
subfamily_ILKAP_pd Subfamily ILKAP 101-361 1.3e-42 139.0 In-house 11-289 (293) alignment 
Range on Protein: 101-361
Range on HMM: 11-289/293.0
SMQGWRVEMEDAHTAVIGLP-------SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfKGSAGAPSvENVKNGIRTGFLEIDEHMRVMSEKKH
  .| | ||.|||. .  |        | ... |..||.||||||. .... |.|  .| ..   |..  |   ...|. .   | . ||..  ...|..
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklp.ksdvsake.keikkclvdsfkktdeefLklaskak

GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH------FFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVhGkgpteql
 . . ||||. ||.  .  |  | |||. .|.|. .         .|.||.| .  |..||| |||.|   ||.| | |||..||  .| . |       
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl.G.......

VSPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDL----------------EKVCNEVVDTCLYKGSRDNMSVIL
|.  |.|. .| .|  |.|..|||||.|.|. ..|  .|. . ||  .|                 | .|| .    . .|| ||..|.|
vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvll
subfamily_PPM1L_pd Subfamily PPM1L 101-366 5.4e-42 136.9 In-house 11-268 (269) alignment 
Range on Protein: 101-366
Range on HMM: 11-268/269.0
SMQGWRVEMEDAHTAVIGLPSGLEsWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQ-DFKGSAGAPSVENVKNGIRTGFLEIDEHMrvMSEKKHGADRSG
|..| | .|||  .   ..  . .  |||||.||| |   |... . | . | |.  ... .       | .. .    | .||..  . . |.  | .|
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekl..lekakraediaG

STAVGVLISPQHTYFINCGDSRGLLCRNRKV-HFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpTEQLVSPEPEVH
.||.  |.. ..    | |||||.|. .|     .. |||| .. |. ||..||| . .    ||.| ||.||||||.  |        ..|| ..|.. 
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadpdil

DIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKvcnEVVDTCLYKGSRDNMSVILICFPN
 ..  . . .|.|||.||.|| . ||| . |.. ||.  |   |    .|  . ..|| ||..|... . |
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGak...slvlesfkrGsvdnitvlvvklkn
subfamily_PPM1K_pd Subfamily PPM1K 98-364 2e-40 131.6 In-house 7-258 (263) alignment 
Range on Protein: 98-364
Range on HMM: 7-258/263.0
GLSSMQGWRVEMEDAHTaVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfkgsagapSVENVKNGIRTGFLEIDEHMRVMSEKK---HG
|  |..| | | ||  . .  |    .   ..||.||||||  |... ..|  ....  .          ....  ..  |.|.|....   | .   . 
GkdsliGkraenedrik.lkeld...pellyvavfdGhaGsaaadfvhdklekilkrlle........kekdleivlknafeeldkklkrylefsvaeae

ADRSGSTAVGVLISP-QHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI-----QRVNGSLAVSRALGDFDYKCVhGkgpteqlV
   ||.||  .|.   ..    . |||| .|||| | . .|.||.|.   |||||..|||||        .||| ||..|.|||.| |   |       |
llssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry.G.......v

SPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRsrleVTDDLEKVCNEVVDTCLYKGSRDNMSVILICF
  .|| . .. . ..| |..|  ||| .|. ..||||.||    .  | |.  . .... |  || || ..... .
iatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvpl
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 358-437 1.7e-38 120.2 Pfam-A 1-81 (81) alignment 
Range on Protein: 358-437
Range on HMM: 1-81/81.0
SVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKK-QGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNR
|.||.|||.||||| |||||||||||.||.||||||.| . |.||||..|..|||||.|| |||||.|||||.||||||..
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavykk
subfamily_PPM1D_pd Subfamily PPM1D 100-258 1.1e-29 96.5 In-house 7-174 (309) alignment 
Range on Protein: 100-258
Range on HMM: 7-174/309.0
SSMQGWRVEMEDAHTAVIGL-PSGL-ESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFkgsaGAPSVENVKNGIRTGFLEIDEHMRVMSE----KKH
.. || |  |||  . |.   .|..  ...|.||.||| | . ||.  |||.  |.....|     . . |.| . || .||.. | |.   |    .|.
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf....lssepedvleAireaflatheamkkkleeWpktks

G-ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK------VHFFTQDHKPSNPLEKERIQNAGGSVMIQ
|    .|.||  |.|  .. |  . |||. .|  . .       .  |.||||..| |||||...||.|...
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_PPM1G_pd Subfamily PPM1G 77-186 1.2e-27 90.1 In-house 1-100 (473) alignment 
Range on Protein: 77-186
Range on HMM: 1-100/473.0
FLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGsagapsvENVKNGIRT
.|.|||.||.. ..  ..|.|| |.||||||..||||.... |    | .|.||||||| |..||||. ..|.| ..... .|        ..|..... 
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgyke.......gdvekalee

GFLEIDEHMR
 ||..||...
aflalDeklk
subfamily_KAPP-like_pd Subfamily KAPP-like 107-362 2.2e-25 82.2 In-house 10-264 (266) alignment 
Range on Protein: 107-362
Range on HMM: 10-264/266.0
VEMEDAHTAVIGLPSGLE-----SWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDF-KGSAGAPSVENVKNGIRTGFLEIDEHMrvmseKKHGADRSGS
.|||| . |.  |    .       ..|||.|||||  .|.   . . . . .  .  |   |  .. . .. ..  | |.|...     |..  . . .
temedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdakl.....kdfeyeGata

TAVGVLISPQHTYFI--NCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM--IQRVNGsLAVSRALGDFDYKCVHGKgpteqlVSPEPEVHD
| . |  . |  |    | |||  .|.|  .  ....|||  .| || ||.. | ..     |.|| |||||||||   |           .. || | .
tlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG......lisepyvsn

IERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYK-GSRDNMSVILI
       |.|.|.| ||.|||.  ..  . |.|  .  .  .|... ...| .    ..||.|||..
rilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 108-362 7.2e-23 73.8 In-house 10-274 (276) alignment 
Range on Protein: 108-362
Range on HMM: 10-274/276.0
EMEDAHTAVIGLPSGLE-----SWSFFAVYDGHAGSQVAKYCCE----HLLDHITN--NQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGAD
|||| . |.  |    .       ..|||.|||||  .|.   .     |.  .        |   |  .. . .. .   | |.|....    .   | 
emedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatat

RSGSTAVGVLISPQHTYFI---NCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM--IQRVNGsLAVSRALGDFDYKCVHGKgpteqlVSPE
 .     |     |.  ..   | |||  .|.|  .  ....||| ..| ||.||.. | ..     |.|| |||||||||   |           .. |
lalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG......lise

PEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYK-GSRDNMSVILI
| | .       |.|.|.| ||.|||.  ..  . |.|  .  .  .|... ...| .    ..||.|||..
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_PP2D1_pd Subfamily PP2D1 193-333 5.2e-22 71.2 In-house 171-308 (492) alignment 
Range on Protein: 193-333
Range on HMM: 171-308/492.0
HGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM----IQRVNGSLAVSRALGDfdykcvHGKGPTEQLV
.| ... ..    |. .   |  | |. . .|||. |    |..| | |. |..|...||..|.      .||| | . | ||       .| .  .. |
eGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGn......yGdpkLkksv

SPEPEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRLEV
 |||... ..  .| .||..||  |.|.|. .||    |.. |..
ipePkttsvkl.deaaqflvlAsnGlWevlseeevlsLvkqtlai
PPM_PTC7_motif 308-357 3.3e-19 62.1 In-house 1-51 (51) alignment 
Range on Protein: 308-357
Range on HMM: 1-51/51.0
ILACDGIWDVMGNEELCDFVRSRLE-VTDDLEKVCNEVVDTCLYKGSRDNM
|||.||.|||. ..|..|.||..|.   ..........||..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PDP_pd Subfamily PDP 167-349 1.3e-18 60.2 In-house 112-330 (398) alignment 
Range on Protein: 167-349
Range on HMM: 112-330/398.0
VENVKNGIRTGFLEIDEHMRVMSE---KK------HGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQNAG
||.||. ....||..|. ..  .    |.        .  ||..|. .||.... .  | ||.| .|.....     .  ...|.  .|. | |||... 
vekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeH

---GS---VMIQRVNGSLAVSRALGDFDYKCVH--GKGPTE----------QL-----VSPEPEVHDIeRSEEDDQFIILACDGIWDVMGNEELCDFVRS
    |   .. .|. |.|. .|| ||. ||  .   | . |          ..     .. ||||    . .|.|.|..|| ||.||.. |||  . |  
PgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtsh.klrendkFLvlatDGLwdllsneevvslVge

RLEVTDDLEKVCNEVVDTCL
 |. ... |.|  |  .. |
hlakkkekepvkveeakltl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 122-273 7.9e-16 51.4 In-house 16-183 (292) alignment 
Range on Protein: 122-273
Range on HMM: 16-183/292.0
GLESWSF-FAVYDGHA--GSQVAKYCCEHLLDHITNNQdfkgsagaPSVENVKNGIRTGFLEIDEHMRvmsEKKHGADRSGSTAVGVLISPQH--TYFIN
| |. .|  ||.|||   | .||..  ..|  ....          .   .. . .  . |.|  ...   .    |  |..|||   . .     .  |
gsealtflaavldGhGvnGdkvaqlaedtlevellelt........rqlqelsealllrildiaakld...kltidaresattavvcarvrddralilan

CGDSRGLLCR-----NRKVHFFTQDHKPSNPLEKERIQNAGGSVM-----------IQRV------NGSLAVSRALGDF
 |||| || |     . ..   ..||||..| |..||..||| |              ||      .| ||.|||||||
vGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
subfamily_PPM1D_pd Subfamily PPM1D 264-364 2.5e-14 46.1 In-house 201-307 (309) alignment 
Range on Protein: 264-364
Range on HMM: 201-307/309.0
LAVSRALGDF-DYKCVHGkgptEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDD----LEKVCNEVVDTCLYKGSR----
|||.|.|||.  |.   |    | .|||||.| . ..  ....||||| ||.|.|.  |.  ..|..  |..       ..| . .|.. | . ..    
LavaRslGDlWsynaksg....efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr

-DNMSVILICF
 ||.|||....
aDnvsvivvil
PP2C_SIG_SM00331 182-362 1.9e-13 43.5 In-house 71-215 (217) alignment 
Range on Protein: 182-362
Range on HMM: 71-215/217.0
DEHMRVMSEKkHGADRSGSTAVGVL--ISPQHTYFINCGDSRGLLCRNRKVHFFTQDhkpsnplekeriqnaggsvmiqrvngslavsralgdfdykcvh
 . .|.. |. .. .... |..  |  .| .. ...|.|||| .| |..|  . ..|                                           
krlnraiyee.keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd...........................................

gkgPTEQLVSPEPEVH--DIERSEEDDQFIILACDGIWDVM-----GNEELCDFVRSRLevTDDLEK----VCNEVVDTCLYKGSRDNMSVILI
   .. .... ||||     |.. | . ...|. ||.....     ..|.|...... .  .. ...      .|.. .   .. .|...|...
...vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_TAB1_pd Subfamily TAB1 197-347 1.2e-12 40.3 In-house 128-298 (333) alignment 
Range on Protein: 197-347
Range on HMM: 128-298/333.0
RSGSTAVGVLISPQHTYFINCGDSRGLLCR---NRKVHFFTQDHKPSNPLEKERIQNAGG-SVMIQR--VNGSLAVSRALGDFDYKCVHG-----KGPTE
. |.||| .||  .. | .|.|||| ||..   . ||.   .||.  |. | .|... |     |.|  . ||    |..||.  |  .      .  ..
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakg

QLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNE--------E-LCDFVRSRLEVTDDLEKVCNEVVDT
. |  ||...     ..  .|..|  ||.   . .         | .   |  .||   .|..| ..||| 
ePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdk
subfamily_PPM1H_pd Subfamily PPM1H 258-338 4.5e-12 38.4 In-house 275-358 (404) alignment 
Range on Protein: 258-338
Range on HMM: 275-358/404.0
QRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVH--DIER-SEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLE
.|. . ..|.| ||| . | |. .     ..||.|||.  |..  ....|. .||| ||.|||. |||    ||. |. ... .
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskveped
Subfamily Dicty-PPM1L-like 259-364 3.2e-11 35.6 In-house 200-303 (305) alignment 
Range on Protein: 259-364
Range on HMM: 200-303/305.0
RVNGSLAVSRALGDFDYKCVHGkgpteqlvsPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD-------DLEKVCNEVVDTCLYK
.||. | .||  || . |..           |... .    .. .|||..|| ||.|.|. .... ..|.  |. .        | . . . .|   . .
lvnrllkksrskGdknlkelvi.........PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkr

GSRDNMSVILICF
||.||. ...| .
gsgDnitlviikl
PPM_PTC7_SpoIIE_motif 304-364 2.1e-10 34.2 In-house 12-80 (81) alignment 
Range on Protein: 304-364
Range on HMM: 12-80/81.0
DQFIILACDGIW-------DVMGNEELCDFVRSRlEVTDdLEKVCNEVVDTCLYKG---SRDNMSVILICF
.  ..|..||..       ...|.|||....... |. . |.... ..||..|  |   ..|.........
gdvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlrv
subfamily_PPM1H_pd Subfamily PPM1H 171-250 1.3e-09 30.3 In-house 137-212 (404) alignment 
Range on Protein: 171-250
Range on HMM: 137-212/404.0
KNGIRTGFLEIDEHMRvmSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNplEKERIQN
.  . . |||.|| ..   |...  .. | ||. .|.  .  |  | |||| .|.|..... . .|. |    |..|.|.
iGalesaflemDeqia..rereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlqe
subfamily_PHLPP_pd Subfamily PHLPP 214-361 1.7e-08 26.6 In-house 109-242 (246) alignment 
Range on Protein: 214-361
Range on HMM: 109-242/246.0
FINCGDSRGLLCRNRKVHFFTQDHKPSNPlEKERIQNAGGSVMI-QRVNGSLAVSRALGDFdykCVHgkgPteqLVSPEPEVHDIERSEeDDQFIILACD
  . |     |.|| |   ... .. ..  | .||..| . .   ...|| .. .| || .    ..   |    | |.|.|...  .| .| ..|.  .
vAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGyt...flf...P...vvlPkphvrevlLte.qdellivGnk

GIWDVMGNEELCDFVRSRlevTDDLeKVCNEVVDTCLYKGSRDNMSVIL
 .|.|.  .|. . ||      | |  .   .||     | .|..||. 
alWevlsideaveavrke...edpl.vaAkklvdlaqsygaadsvsvlv
Subfamily Dicty-PPM1L-like 211-272 2e-07 23.1 In-house 227-294 (305) alignment 
Range on Protein: 211-272
Range on HMM: 227-294/305.0
HTYFI-NCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG-----SVMIQRVNGSLAVSRALGD
. . . . .|....|... . . . ..... ...|. |..  ..        | || . .||.|  ||
pllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
Subfamily Dicty-PPM1L-like 96-154 1.1e-06 20.7 In-house 8-64 (305) alignment 
Range on Protein: 96-154
Range on HMM: 8-64/305.0
RYGLSSMQGWRVEMEDAHTAVIGLPSGLEsWSFFAVYDGHAGSQVAKYCCEHLlDHITN
.|.|   .. |   || .   |.| |  |  |.| |.||| | . |.|   .|  .| |
kyelyvsansrkyqedrnkvkislessqe.lslfGvfdGhnGdiaaeyvkkkl.veivn
PP2C_2 Protein phosphatase 2C 125-332 3e-06 19.7 Pfam-A 23-196 (212) alignment 
Range on Protein: 125-332
Range on HMM: 23-196/212.0
SWSFFAVYDGHAG---SQV-AKYCCEHLLDHITNNQDFKGSA-GAPSVENVKNGIRTGFLeideHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD
.....|| ||.     |.. |.. .| ........ . .  .  .  .....|.|..       .    ..... ..  ..| . ..|.|.. .|...||
dgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyatTlllavitpgeivffqiGD

SRG-LLCRNRKVHFFTQDHKpsnplekERIQNAggsvmiqrvNGS---------LavsralgdfdykcvhgkgpteqlvspepevhDIERSE-EDDQFII
..  .  |. .|. ......         ..|            .         |                               .|.| . |. . ..
gaivvrdrdgevqllgepds.......geyane.........ttfltsedaeeel...............................rirrlklepgdall

LACDGIWDVMG-NEELCDFVRSRLE
|  ||..| .  .|.. .... .||
lmTDGvsdslrkeepfrellaelle
PP2C_2 Protein phosphatase 2C 125-332 3e-06 19.7 In-house 23-196 (212) alignment 
Range on Protein: 125-332
Range on HMM: 23-196/212.0
SWSFFAVYDGHAG---SQV-AKYCCEHLLDHITNNQDFKGSA-GAPSVENVKNGIRTGFLeideHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD
.....|| ||.     |.. |.. .| ........ . .  .  .  .....|.|..       .    ..... ..  ..| . ..|.|.. .|...||
dgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyatTlllavitpgeivffqiGD

SRG-LLCRNRKVHFFTQDHKpsnplekERIQNAggsvmiqrvNGS---------LavsralgdfdykcvhgkgpteqlvspepevhDIERSE-EDDQFII
..  .  |. .|. ......         ..|            .         |                               .|.| . |. . ..
gaivvrdrdgevqllgepds.......geyane.........ttfltsedaeeel...............................rirrlklepgdall

LACDGIWDVMG-NEELCDFVRSRLE
|  ||..| .  .|.. .... .||
lmTDGvsdslrkeepfrellaelle
subfamily_PP2D1_pd Subfamily PP2D1 105-150 8.4e-06 17.7 In-house 13-57 (492) alignment 
Range on Protein: 105-150
Range on HMM: 13-57/492.0
WRVEMEDAHTAVIGLPSGLESwSFFAVYDGHAGSQVAKYCCEHLLD
|. .|||..| .       .| .||..|||. |.  |. . ..| .
WKskmeDkrtlqdyfgndvns.cFfgiyDGynGataAeiaakelhe