Gene PPM1A in Homo sapiens

Synonym: PP2C-ALPHA, PP2CA, PP2Calpha, PPM1A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP174_AA protein Get Run
HsapP174_AA_75-367 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 81-366 2.2e-131 430.4 In-house 3-282 (282) alignment
PPM_PTC7 96-357 5.3e-94 307.5 In-house 2-259 (259) alignment
PP2C Protein phosphatase 2C 96-357 3.9e-92 301.4 Pfam-A 2-255 (255) alignment
PP2C Protein phosphatase 2C 96-357 3.9e-92 301.4 In-house 2-255 (255) alignment
0034914 PP2C-like 76-367 4.8e-92 300.7 In-house 2-293 (295) alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 78-364 1.2e-86 283.2 In-house 2-286 (287) alignment
PP2Cc_SM00332 87-362 1.1e-84 277.1 In-house 2-274 (274) alignment
0049733 PP2C-like 95-365 2.5e-63 206.4 In-house 3-234 (235) alignment
subfamily_PPM1E_pd Subfamily PPM1E 100-364 3.2e-55 180.1 In-house 9-262 (265) alignment
PPM_PTC7_SpoIIE 96-347 3.5e-51 167.2 In-house 2-220 (230) alignment
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 94-365 5.5e-50 163.0 In-house 5-254 (255) alignment
subfamily_PPM1G_pd Subfamily PPM1G 188-365 3.3e-49 161.1 In-house 286-471 (473) alignment
subfamily_ILKAP_pd Subfamily ILKAP 101-361 1.3e-42 139.0 In-house 11-289 (293) alignment
subfamily_PPM1L_pd Subfamily PPM1L 101-366 5.4e-42 136.9 In-house 11-268 (269) alignment
subfamily_PPM1K_pd Subfamily PPM1K 98-364 2e-40 131.6 In-house 7-258 (263) alignment
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 358-437 1.7e-38 120.2 Pfam-A 1-81 (81) alignment
subfamily_PPM1D_pd Subfamily PPM1D 100-258 1.1e-29 96.5 In-house 7-174 (309) alignment
subfamily_PPM1G_pd Subfamily PPM1G 77-186 1.2e-27 90.1 In-house 1-100 (473) alignment
subfamily_KAPP-like_pd Subfamily KAPP-like 107-362 2.2e-25 82.2 In-house 10-264 (266) alignment
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 108-362 7.2e-23 73.8 In-house 10-274 (276) alignment
subfamily_PP2D1_pd Subfamily PP2D1 193-333 5.2e-22 71.2 In-house 171-308 (492) alignment
PPM_PTC7_motif 308-357 3.3e-19 62.1 In-house 1-51 (51) alignment
subfamily_PDP_pd Subfamily PDP 167-349 1.3e-18 60.2 In-house 112-330 (398) alignment
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 122-273 7.9e-16 51.4 In-house 16-183 (292) alignment
subfamily_PPM1D_pd Subfamily PPM1D 264-364 2.5e-14 46.1 In-house 201-307 (309) alignment
PP2C_SIG_SM00331 182-362 1.9e-13 43.5 In-house 71-215 (217) alignment
subfamily_TAB1_pd Subfamily TAB1 197-347 1.2e-12 40.3 In-house 128-298 (333) alignment
subfamily_PPM1H_pd Subfamily PPM1H 258-338 4.5e-12 38.4 In-house 275-358 (404) alignment
Subfamily Dicty-PPM1L-like 259-364 3.2e-11 35.6 In-house 200-303 (305) alignment
PPM_PTC7_SpoIIE_motif 304-364 2.1e-10 34.2 In-house 12-80 (81) alignment
subfamily_PPM1H_pd Subfamily PPM1H 171-250 1.3e-09 30.3 In-house 137-212 (404) alignment
subfamily_PHLPP_pd Subfamily PHLPP 214-361 1.7e-08 26.6 In-house 109-242 (246) alignment
Subfamily Dicty-PPM1L-like 211-272 2e-07 23.1 In-house 227-294 (305) alignment
Subfamily Dicty-PPM1L-like 96-154 1.1e-06 20.7 In-house 8-64 (305) alignment
PP2C_2 Protein phosphatase 2C 125-332 3e-06 19.7 Pfam-A 23-196 (212) alignment
PP2C_2 Protein phosphatase 2C 125-332 3e-06 19.7 In-house 23-196 (212) alignment
subfamily_PP2D1_pd Subfamily PP2D1 105-150 8.4e-06 17.7 In-house 13-57 (492) alignment