Gene PPM1N in Homo sapiens

Synonym: PPM1N

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP176_AA protein Get Run
HsapP176_AA_61-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 62-327 3.1e-98 321.6 In-house 9-281 (282) alignment 
Range on Protein: 62-327
Range on HMM: 9-281/282.0
SGGLRFGASAAQGWRARMEDAHCTWLSLPgLPPGWALFAVLDGHGGARAARFGARHLPGHVLQ-----ELGPEPSEPEGVREALRRAFLSADERLRSLWP
  |||.| |..||||..|||||... ||.   ..|..|||.|||.|...|.. ..||....|.     |   | || . |.||||..||..||..|.|. 
gnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

RVET---GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSA
...|    |.|||..|||.. |..|..|||||||.| |..||.||||.| ||.|..||..|||..  .||.|.|||||||||..|||.. ...| |||||
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFP
||||... |. ||.|..||.||.||..| . .. ||..||. .  .| ....|.|..|.||| ||.....|.|.
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
0034914 PP2C-like 62-328 4.7e-77 251.5 In-house 18-292 (295) alignment 
Range on Protein: 62-328
Range on HMM: 18-292/295.0
SGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGP----EPSEPEGVREALRRAFLSADERLRSLWPR
   ||.|..  ||.|  .|||....|.|. | ....||.| ||||| .||.. ...|. ..|..|       ....| ..||||.|||.|||.|..|. .
llllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall

---VETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAE
   . ..|.||||.|. ...||.|..|||||||.| | . . |.||.| .. ||||| .|||...  || |.|||.|||||| .|  . .... .|||||
rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsae

PEVAALARQ-AEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPG
|.|  | ..  .|.|.||||||.||..|   .. .|.|.|. || .| .. .|.| .| .|| ||.|...|...|
PdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 64-326 4.5e-70 228.8 In-house 18-286 (287) alignment 
Range on Protein: 64-326
Range on HMM: 18-286/287.0
GLRFGASAAQGWRARMEDAHCT---WLSLPGlPPGWALFAVLDGHGGARAARFGARHLPGHVLQelgPEPSEPEGVREALRRAFLSADERLRSL-WPRVE
  ..|.|| ||.|  ||||| .    |...   .  |||||.||||||..|......|   . .    .  . . ....|. |||. || |..    . |
ltkvgssamqGyrlnmeDahilenelleksd.dkslalfavfDGhGGakvakyagkklikkiak...kksfkegaleqilkdafletDeellkdeklkde

TGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAA
. |.|||| |.. . || | .|||||||| .| |   . ||.| .  |..|| ||||..   || |.||.|||||||..|.    .|| |.| |.|.|  
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlv

LARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSL------DNMTCILVCF
  .. .|||..|| ||.|| .. . .  || .||. | ... .. .|||.|| . |       ||||...|..
kkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2Cc_SM00332 63-324 6e-69 225.5 In-house 8-274 (274) alignment 
Range on Protein: 63-324
Range on HMM: 8-274/274.0
GGLRFGASAAQGWRARMEDAHCTWLSLPgLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSE-PEGVREALRRAFLSADERLRS----LWPR
 ||..| |. |||| .|||||.. ..|     .|..|.| |||||...|.| ...|| .. .||  . .|  . | |||..||||.||...     ....
lglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele

VETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKEAPgrPPELQLVSAEPEV
 .. |.|||| |..   ||.|..|||||||.|.| .   ..||.| ...||.||..|||.....|| |.||||||.||. .|..   ... . ..|||.|
nalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaepdv

AALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGL------APELLCAQLLDTclcKGSLDNMTCILV
  ..   ||||..|||||.|| .|   . ..| ..|. |       | |||.......   .|| ||.|...|
kvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr...ggseDniTvvvv
PP2C Protein phosphatase 2C 66-319 3.3e-65 213.2 Pfam-A 2-255 (255) alignment 
Range on Protein: 66-319
Range on HMM: 2-255/255.0
RFGASAAQGWRARMEDAHCTWLSLP--GLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEpeGVREALRRAFLS-ADERLRSLWPR--VET
..|||..||.|  |||||.   .|   .    .|.||| ||||| .||.. . ||.... .    ...|   |..|||..||. .||.|.|   .   ..
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskantepsk

GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVA-FSTEDHRPLRPRERERIHAAGGTIR-RRRVEGSLAVSRALGDFTYKEAPgrppeLQLVSAEPEVA
 |.|||| |...  ||.|..|||||||.|..  . . ||||.| ...||||| .|||..    || |||||||||||| .|. .      |||||||.| 
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvt

ALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNM
   .. ||||..|||||.|| .|   .. || |.|  . .|. .. .|.| .. .|| ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 66-319 3.3e-65 213.2 In-house 2-255 (255) alignment 
Range on Protein: 66-319
Range on HMM: 2-255/255.0
RFGASAAQGWRARMEDAHCTWLSLP--GLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEpeGVREALRRAFLS-ADERLRSLWPR--VET
..|||..||.|  |||||.   .|   .    .|.||| ||||| .||.. . ||.... .    ...|   |..|||..||. .||.|.|   .   ..
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskantepsk

GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVA-FSTEDHRPLRPRERERIHAAGGTIR-RRRVEGSLAVSRALGDFTYKEAPgrppeLQLVSAEPEVA
 |.|||| |...  ||.|..|||||||.|..  . . ||||.| ...||||| .|||..    || |||||||||||| .|. .      |||||||.| 
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvt

ALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNM
   .. ||||..|||||.|| .|   .. || |.|  . .|. .. .|.| .. .|| ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 66-319 3.8e-65 212.9 In-house 2-259 (259) alignment 
Range on Protein: 66-319
Range on HMM: 2-259/259.0
RFGASAAQGWRARMEDAHCTWLSLP--GLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEpeGVREALRRAFLS--ADERLRSLWP--RVE
..||||.||.|  |||||.    |   .    .|.||| ||||| .||.. . ||.... ..   |..|   . .||| .||.  .||.|.|       .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelksseanteps

TGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVA-FSTEDHRPLRPRERERIHAAGGTIR---RRRVEGSLAVSRALGDFTYKEAPGrppELQLVSAEP
|.|.||||.|...  || |..|||||||.| | .. . ||||.| ...||||| .|||..    . || |.||||||.||| .|. .    | |||||||
tsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaeP

EVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGlAPELLCAQLLDTCLCKGSLDNM
..   ....||||..|||||.|| ||   .. || |.|  . .|. .. .|.|... .|| ||.
disstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
0049733 PP2C-like 65-326 3.1e-58 189.7 In-house 3-233 (235) alignment 
Range on Protein: 65-326
Range on HMM: 3-233/235.0
LRFGASAAQGW-RARMEDAHCTwlslpglppGWALFAVLDGHGGARAARFGARHLPGHVLQELGPepSEPEGVREALRRAFLSADERLRSLWPR---VET
|..||.  .|. |  .|||..          |..|||| |||||..|... ...|. ..|..| .   ......||||.||| |.|.|..|. .   . .
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspelag

GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIrrrRVEGSLAVSRALGDFTYKeapgrppelqlvsaePEVAAL
.|.||||.|. ...||.|..|||||.| | | . . ||||.| .. ||.||..||| .   || |.||..|||||...|               |.|  |
mgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvl

ARQAEDeFMLLASDGVWDTVSGAALAGLVASrlrlgLAPELLCAQLLDTCLCKGSLDNMTCILVCF
  ...| |.||||||.|| .|   ...|..|     | .| .. .|....| .|. ||.|...|..
elepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 70-326 1.5e-46 151.8 In-house 9-262 (265) alignment 
Range on Protein: 70-326
Range on HMM: 9-262/265.0
SAAQGWRARMEDAHCTWLSLPGL-----PPGWALFAVLDGHGGARAARFGARHLPGHVLQELGpEPSEPEgvrEALRRAFLSADERLRSL-WPRVETGGC
 | .. | .||| | .  .|  |      .  | |||.|||||  ||.. |.||. .. ..    ...|.   |||..||  .|||. .       ..|.
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqek.lkedpa...ealkeafkltDerflqkaereklksGs

TAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIR---RRRVEGSLAVSRALGDFTYKeapgrppelQLVSAEPEVAAL
|||| |.. . ||.|  |||.|.| | | .   .. |.| |..|..|| .|||..      || |.|.||||.|| ..|         . ||.|..|| .
tavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvaev

ARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGL-APELLCAQLLDTCLCKGSLDNMTCILVCF
. . ..|...||.||.||.|    .  || . |. |    . .  .|...   .|| ||.| ..| .
eldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 161-326 2.5e-44 145.1 In-house 296-470 (473) alignment 
Range on Protein: 161-326
Range on HMM: 296-470/473.0
GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIR-RRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAA
 |.|||| |.  . |. |  ||||.||||.|      .||.|  . |.|||..|||..    ||.| | .||||||..||.    |.. |..|| |..  
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv

LARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGL--APELLCAQLLDTCLCKG------SLDNMTCILVCF
|. . ||||. ||.||.|....       | ..|. |     . .. .|||.|| .         ||||.|.|..
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 66-326 2.1e-40 131.6 In-house 7-253 (255) alignment 
Range on Protein: 66-326
Range on HMM: 7-253/255.0
RFGASAAQGWRARMEDAHCTWLSLPGLpPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEgvrEALRRAFLSADERLrSLWPrvETGGCTA
. | |   | |. |||    . |  .  ..  ..|..||||| .||.| . .|.  . . |  ....|.   ..|..|. . . .. | .|     |.||
kvgfsdmiGrrptmedelviyGsfrdk.sdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi.serp..kfiGtta

VVLLVSPRFLYLAHCGDSRAVLS-RAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR----RVEGSLAVSRALGDFTYKeapgrPpelqLVSAEPEVA-A
...|.   . |.|  ||||.||. . |     . ||.|  ..|..||...|||.       ||.| |||||||||   .     |     | ..|..  .
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P....fvvpdPdlsqs

LARQAEDEFMLLASDGVWDTVSGAALAGLVASRLrlglAPELLCAQLLDTCLCKGSLDNMTCILVCF
|  . .|.|..|| ||.|| .|      .||.       ||  . .| |    .|| ||.. |.. .
leiskkdkflilacdGiwdlisdeeaveivagis....dpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 71-326 2.2e-34 111.9 In-house 11-266 (269) alignment 
Range on Protein: 71-326
Range on HMM: 11-266/269.0
AAQGWRARMEDAHCTWLSLPGlPPGWALFAVLDGHGGARAARFGARHLPGHVLQEL-----GPEPSEPEGVREALRRAFLSADERLR-SLWPRVETGGCT
. .| | ||||       .     |  .||| |||||  || |    |.  ....|       | .||    . |    ||.||.|   .    .. |.|
svlGrrprmedrfeieedikn.ktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtt

AVVLLVSPRFLYLAHCGDSRAVLSRA-GAVAFSTEDHRPLRPRERERIHAAGGTIRRR---RVEGSLAVSRALGDFTYKEapgrppeLQLVSAEPEVAAL
|.. ||. . | .|  |||| ||    |     . ||.| ...|| ||. ||| |  |   ||.| ||.||||||.  |.        .|| |.|.. ..
alialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadpdiltf

AR-QAEDEFMLLASDGVWDTVSGAALAGLVASRLRlglAPELLCAQLLDTCLCKGSLDNMTCILVCF
   . . ||..|||||.||| |       .  ||     |..    |   .  .||.||.| ..| .
dlddhkpeflilasdGlwdtfsneeavrfikerlk...epdfGakslvlesfkrGsvdnitvlvvkl
PPM_PTC7_SpoIIE 66-318 8.1e-34 110.4 In-house 2-229 (230) alignment 
Range on Protein: 66-318
Range on HMM: 2-229/230.0
RFGASAAQGWRARMEDAHCTWLSLP--GLPPGWALFAVLDGHGGARaaRFGARHLPgHVLQELGPEPSEpeGVREALRRAFLSADERLRSLwprVETGGC
..|||||||.|  |||||.    .   .    ...... |||||     . ...|   .|.||  . .|   . |.|||..| .. .|..    ....|.
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrelafagle..kpeeilrrlnlalaadlede...psssga

TAVVLLVSPRF--LYLAHCGDSRAVLSRAGAVafstedhrplrprERERIhAAGGTIR----RRRVEGSLAVSRALGDFTYKEapgrppELQLVSAEPEv
||||.|. |    ||.|..|||...|.|...              ||||| .||| ..      || |.||||.| ||. ..       . ..|.|||. 
TavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.

AALARQA-EDEFMLLASDGVWDTVSGAALAGLVASRLRLGlapelLCAQLLDTCLCKGSLDN
    .   .|||. |||||.|| .| . |. || ..|        .. .||. ... .....
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDitllvvrv
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 320-398 1.8e-33 104.1 Pfam-A 1-81 (81) alignment 
Range on Protein: 320-398
Range on HMM: 1-81/81.0
TCILVCFPGAPRPSEEAIRRELALDAALGCRIAELC--ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQ
..|||||||||..||||...| .||.|| .|..|..  .|... |.|..|..||||||||.|||||||..|..||..||..
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavykk
subfamily_PPM1D_pd Subfamily PPM1D 68-291 2.7e-33 108.4 In-house 5-263 (309) alignment 
Range on Protein: 68-291
Range on HMM: 5-263/309.0
GASAAQGWRARMEDAHCTWLSL--PGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGVREALRRAFLSADERL---RSLWPRVE---
 ..| || |  |||  .  |.    ... ..| .|| |||||  ||.|  .|| . . .. .   |||| |.||.|.|||.  | .   .. ||. .   
tseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgl

--TGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGA------VAFSTEDHRPLRPRERERIHAAGGTIRRR----RV---------EGS--------LAVS
  | | || |...  . ||.|| |||..||.              |.||.|  |.|.|||. .|| .  .    ||         .|         |||.
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLava

RALGDF-TYKEAPGRppelQLVSAEPEVAALARQAEDE-FMLLASDGVWDTVSGAALAGLVAS
|.|||.  |... |.     .|| ||.|    .. ..| |..|||||.|. .....   .| .
RslGDlWsynaksge....fvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvek
subfamily_ILKAP_pd Subfamily ILKAP 96-285 6.4e-32 103.9 In-house 43-235 (293) alignment 
Range on Protein: 96-285
Range on HMM: 43-235/293.0
WALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEP--EGVREALRRAFLSADERLRSLWPRV---ETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRA
 . .|| |||.| ||..| |..|  ..|..|  .      . .. .|  .|   || . .|  .       |.||.|.||    || |  |||.||| | 
vsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrk

GA------VAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKEApGrppelqlVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAA
        .   | || | .  ||.||. |||..|  || | | |||..||  .|.. |       |.. |.|  .  .  | |..|| ||.|...|  .
keegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl.G.......vistPdvkkceLtendlfvvlaCdGLwkvfsade

L
 
v
subfamily_PPM1K_pd Subfamily PPM1K 68-326 8.6e-31 100.0 In-house 7-258 (263) alignment 
Range on Protein: 68-326
Range on HMM: 7-258/263.0
GASAAQGWRARMEDAHCtwlsLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELgpePSEpEGVREALRRAFLSADERLRSLWPR------VETG
|  . .| ||  ||  .    |  | |    .|| |||.|. || |   .|  .. . |   . | . ... |..||.  |..|..           .. 
GkdsliGkraenedrik....lkeldpellyvavfdGhaGsaaadfvhdklekilkrll...eke.kdleivlknafeeldkklkrylefsvaeaellss

GCTA-VVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIR-----RRRVEGSLAVSRALGDFTYKEApGrppelqlVSAEP
| || |.||     | ||  |||||.| | |     |.|| | .  |.|||.||||..      . .|.| ||..|.|||.. |.  |       | |.|
GttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry.G.......viatP

EVAALAR-QAEDEFMLLASDGVWDTVSGAALAGLVasrlRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCF
|   |    |.| |..| .||. . |.   |. ||    ||   ||     | .. |  || || |...| .
etkslkvdhaadsflvlitdgisfvvnsqelcdlv....rlchdpeeaahalteqalqygsednatavvvpl
subfamily_KAPP-like_pd Subfamily KAPP-like 97-324 2.9e-23 75.2 In-house 35-264 (266) alignment 
Range on Protein: 97-324
Range on HMM: 35-264/266.0
ALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGV-REALRRAFLSADERLRSLWPRVETGGCTAVVLLVS----PRFLYLAHCGDSRAVLSRAG
|||||.||| |  ||    . .|  . . |     .  |      .. .. | . . .     |  |.|| . ||      |.|  |  ||| | |||  
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaflsrGn

AVAFSTEDHRPLRPRERERIHAAGGTIR--RRRVEGsLAVSRALGDFTYKEApgrppELQLvSAEPEVAA-LARQAEDEFMLLASDGVWDTVSGAALAGL
   . . ||.   |.|. ||.  | |.   . |..| |||||||||   ||      .. | ..|| |.  ..    |.|...||||.|| .||      
eslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel.....niGl.isepyvsnrilltpfdkflivasdGlwdvisGkdaiek

VASRLRLGLAPELLCAQLLDTCLCK-GSLDNMTCILV
| |    . . . ... ||.| .    . ||.. |.|
vkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 97-324 3e-20 65.2 In-house 34-274 (276) alignment 
Range on Protein: 97-324
Range on HMM: 34-274/276.0
ALFAVLDGHGGARAARFGARHLPGHVLQELGP----EPSEPEGV--REALRRAFLSADERLRSLWPRVETGGCTAVVLLV----------SPRFLYLAHC
|||||.||| |  ||    . .|  ... |         . .|       .. .| . . . .     |  |.|| . ||            |.|  |  
alfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvanv

GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIR--RRRVEGsLAVSRALGDFTYKEApgrppELQLvSAEPEVAA-LARQAEDEFMLLASDGVW
||| | |||     . . ||.   | |..||.  | |.   . |..| |||||||||   ||      .. | ..|| |.  ..    |.|...||||.|
GdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel.....niGl.isepyvsnrilltpfdkflivasdGlw

DTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCK-GSLDNMTCILV
| .||      | |    . . . ... ||.| .    . ||.. |.|
dvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 98-249 9e-20 64.4 In-house 23-197 (292) alignment 
Range on Protein: 98-249
Range on HMM: 23-197/292.0
LFAVLDGHG--GARAARFGARHLpGHVLQELGPEPSEpegVREALRRAFLSADERLRSLWPRVETGGCTAVVLLVSP--RFLYLAHCGDSRAVLSR-AG-
| |||||||  | . | . . .| .. | || ..  |   . |||    |.   .|. |       . ||||  . .  | |.||. |||||.| |  | 
laavldGhGvnGdkvaqlaedtl.evelleltrqlqe...lsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclgg

---AVAFSTEDHRPLRPRERERIHAAGGTIR-----------RRRV------EGSLAVSRALGDFTYKEAPG-RPPELQ
    .   . ||.|  | ||.|| .||| .              ||      || ||.|||||||  .||     ||||
sdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelq
subfamily_PPM1G_pd Subfamily PPM1G 61-152 7.7e-18 57.7 In-house 15-100 (473) alignment 
Range on Protein: 61-152
Range on HMM: 15-100/473.0
ASGGLRFGASAAQGWRARMEDAHCTwlsLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQElgpEPSEPEGVREALRRAFLSADERLR
.. .|..|||| ||||. .|||| .   .. |   ..|||| |||||.  |.. |..||. . ..   .  . . |..||. |||. ||.|.
sneelsygasamqGwrvsqEDahnc...itdldedtslfavyDGHGGkevakyvakklpdllkaq...kgykegdvekaleeaflalDeklk
subfamily_PP2D1_pd Subfamily PP2D1 169-294 1e-17 57.0 In-house 184-307 (492) alignment 
Range on Protein: 169-294
Range on HMM: 184-307/492.0
LVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIR----RRRVEGSLAVSRALGDFtykeapGRPPELQLVSAEPEVAALARQA
|. .  ||.|. |. .||| |.|     | .| |  ..||.|.. ||...       .|.| | . | || .      | |   . |  ||.. .   . 
leelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny......GdpkLkksvipePkttsvklde

EDEFMLLASDGVWDTVSGAALAGLVASRLR
.. |..||| |.|. .|    . || . |.
aaqflvlAsnGlWevlseeevlsLvkqtla
subfamily_PDP_pd Subfamily PDP 157-291 5.2e-15 48.4 In-house 148-310 (398) alignment 
Range on Protein: 157-291
Range on HMM: 148-310/398.0
RVETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAV---AFS--TEDHRPLRPRERERIHAA---GG---TIRRRRVEGSLAVSRALGDFTYKEAP---
.| . | .|.. |.... |..|  ||.|||| .            ..|.    ..| |||...         ||. |. |.|. .|| ||. ||      
lvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelq

----------GRPP-ELQ---LVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVAS
           ..| ...    ..|||||     . .| |..||.|| ||..|  . . ||  
kkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVge
PP2C_SIG_SM00331 95-324 6.8e-14 44.9 In-house 29-215 (217) alignment 
Range on Protein: 95-324
Range on HMM: 29-215/217.0
GWALFAVLDGHG-GARAARFGARHLpGHVLQELGPEpsepEGVREALRRAFLSADERlrslwPRVETGGCTAVVLLV--SPRFLYLAHCGDSRAVLSRAG
|  |..| ||.| |..|| . .. . . . ..|  .    | . .||.|.   ..|.       .. ...|....|.  | . |..|..|||| .| | |
grlllvvaDgmGkGlaAaaassqlr.talrellseg....eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllrdg

AVAFSTEDhrplrprererihaaggtirrrrvegslavsralgdfTYKEAPGRPPELQlvsaePEVAALARQAeDEFMLLASDGVWDTVSGAA-----LA
   . ..|                                     .   . |  ||..     .... |  .. ....||..||... .| .      | 
klveilkd.....................................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerle

GLVASRLrlGLAPELLCA----QLLDTCLCKGSLDNMTCILV
..... .  . ... | .    .|| .   ..  |..| ..|
eiledlv..dseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PPM1H_pd Subfamily PPM1H 136-208 5.1e-12 38.2 In-house 136-209 (404) alignment 
Range on Protein: 136-208
Range on HMM: 136-209/404.0
VREALRRAFLSADERLRSLWPR-VETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRER
|  ||  |||. || ..    .   .|||||.| ||    ||.|  |||||.|.| ...    .|. |   |.|
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqR
PP2C_2 Protein phosphatase 2C 94-280 2.1e-11 36.5 Pfam-A 23-181 (212) alignment 
Range on Protein: 94-280
Range on HMM: 23-181/212.0
PGWALfAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGV-REALRRAFLSADE--------RLRSlWPRVETGGCTAVVLLVSPRFLYLAHCGDSR
 || | || ||.| |. .. ||| .   ... |    .| .    |||.|..... .        .  . .  ..  ..| ......|........||..
dgwll.aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGDga

A-VLSRAGAVAFSTEDHRPLRPRErerihaaggtirrrrvEGS---------LavsralgdftykeapgrppelqlvsaepEVAALARQAEdEFMLLASD
. | .|.| |   .|..     .|                  .         |                            ..  | ...  .  || .|
ivvrdrdgevqllgepdsgeyane................ttfltsedaeeel............................rirrlklepg.dalllmTD

GVWDTV
||.| .
Gvsdsl
PP2C_2 Protein phosphatase 2C 94-280 2.1e-11 36.5 In-house 23-181 (212) alignment 
Range on Protein: 94-280
Range on HMM: 23-181/212.0
PGWALfAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGV-REALRRAFLSADE--------RLRSlWPRVETGGCTAVVLLVSPRFLYLAHCGDSR
 || | || ||.| |. .. ||| .   ... |    .| .    |||.|..... .        .  . .  ..  ..| ......|........||..
dgwll.aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGDga

A-VLSRAGAVAFSTEDHRPLRPRErerihaaggtirrrrvEGS---------LavsralgdftykeapgrppelqlvsaepEVAALARQAEdEFMLLASD
. | .|.| |   .|..     .|                  .         |                            ..  | ...  .  || .|
ivvrdrdgevqllgepdsgeyane................ttfltsedaeeel............................rirrlklepg.dalllmTD

GVWDTV
||.| .
Gvsdsl
subfamily_TAB1_pd Subfamily TAB1 149-280 2.4e-10 32.7 In-house 118-260 (333) alignment 
Range on Protein: 149-280
Range on HMM: 118-260/333.0
ERLRSLWPRVeTGGCTAVVLLVSPRFLYLAHCGDSRAVLSR---AGAVAFSTEDHRPLRPRERERIHAAG---GTIRRRRVEGSLAVSRALGDFTYKEAP
|||..| . . .|| |||| |.    || | .|||||.| .      |     ||    . | .|..  |    .|.| .. ||    |..||.. |.  
erlqeleeei.sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgy

GRPPELQLVSAEPEVAAL------ARQAEDEFMLLASDGVWDTV
     |.  . || .|          .    |..| ||||  |.
kdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktL
PPM_PTC7_motif 270-319 1.2e-08 28.3 In-house 1-51 (51) alignment 
Range on Protein: 270-319
Range on HMM: 1-51/51.0
LLASDGVWDTVSGAALAGLVASRLRL-GLAPELLCAQLLDTCLCKGSLDNM
.|||||.|| .|   . .|| ..|   || |. .. .| |..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PPM1H_pd Subfamily PPM1H 216-293 1.2e-07 23.8 In-house 270-351 (404) alignment 
Range on Protein: 216-293
Range on HMM: 270-351/404.0
GTIRRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAAL----ARQAEDEFMLLASDGVWDTVSGAALAGLVASRL
|. .. |. . ..|.| |||   |    .     ..|..|||  |      . ||. ..||.||.|| .|  . | .|.. |
gegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevl
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 249-327 4.7e-07 21.3 In-house 237-316 (317) alignment 
Range on Protein: 249-327
Range on HMM: 237-316/317.0
QLVSAEPEVAALARQAEDEFMLL-ASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFP
  |.|.||| . . .... | ..  |||. | ...  .   |.       | | ||    | .| . | |. | .....|
aGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlllp
PPM_PTC7_SpoIIE_motif 266-326 1.3e-06 22.0 In-house 12-80 (81) alignment 
Range on Protein: 266-326
Range on HMM: 12-80/81.0
DEFMLLASDGVW-------DTVSGAALAGLVASRlrLGLAPELLCAQLLDTCLCKG---SLDNMTCILVCF
.. .||..||..       ....  .|. |....   |  ...|. .|.|..|  |   . |..| .....
gdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlrv