Gene PPM1D in Homo sapiens

Synonym: PP2C-DELTA, WIP1, PPM1D

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP177_AA protein Get Run
HsapP177_AA_3-376 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 7-376 1.7e-153 503.1 In-house 2-308 (309) alignment 
Range on Protein: 7-376
Range on HMM: 2-308/309.0
LGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrrrsSVAFFAVCDG
| |....|||||||||||..||.|.|..|||.                                                          .|||.||.||
lsvtseadqGgrkymeDvvaivleeeesaeel..........................................................evafvavfDG

HGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDpKDD
|||.|||.|||||||..|||||.|.||||..|..|||..|||.| ||.|||.|||||..||.||.||||||||||..|.||||||||..|||.... |..
HGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep.kek

FVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPvrrsTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKH
..|| |.|.||||| |.|.|||| |||.|..||||.|||||||||.||||    ||||.||||||||.|||||||...|||||||||||..|.||||...
klrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngp....tvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpnee

KYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICIS
|.|||.||||||...|.||.|.....||||.|..|...|.||.||..||.|||...|||||.|.||....
kfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvivvile
PPM_PTC7 66-368 1.8e-94 309.0 In-house 2-259 (259) alignment 
Range on Protein: 66-368
Range on HMM: 2-259/259.0
KGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEpaKVCAAIRKGFLACHLAMWKKLaewPKTMT
.|.| |....|....|| ...|.........|||||||.|||||||||..|||||....|..| |...|  |...|.||.|||.......|.   ....|
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant

gLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKddfvraVEVTQDHKPELPKERERIEGLGGSVMNKsGVNRVVWKrprlthngpvrrstvidq
 .|||||.||.|..|.|.|.|||.||||..||.......      ...|.||||....|||||||.||||.|. |..||...                  
.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav......kqltedHkpsnedEreRiegaggsvsnv.gngrvngv..................

ipfLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEKKylmgehgqscAKMLVNRALGRWRQRMLRA
   |||.||.||.........|..||.|||.|....|.. ....||.|||||.....|.|.........||          ..| ....| ...... ..
...lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk..........dpmeaaeklvdeaiargse

DNT
||.
dni
PP2C Protein phosphatase 2C 67-368 2.3e-91 298.9 Pfam-A 3-255 (255) alignment 
Range on Protein: 67-368
Range on HMM: 3-255/255.0
GPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEpaKVCAAIRKGFLAcHLAMWKKLaewPKTMTg
..|.....||....|| ............||||||||.|||||||||..|||||....|.|| |...|  ||..|.||.||| ......|.   .|..| 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKddfvraVEVTQDHKPELPKERERIEGLGGSVMNksgVNRVVWKrprlthngpvrrstvidqi
.||.||.||.|..|||.|.|||.|||| .||...|..|      .|.|.||||. ..||||||..||||.|   ..||...                   
epsksGstavvalirgkklyvAnvGDSravLcrkdnak......keltedHkpsdedEreRIeeaggsvsn...ngrvngs...................

pfLAVARALGDLWSYDFFsgEFVVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYlmgehgqscAKMLVNRALGRWRQRMLRAD
  |||.|||||.......  |..||.|||.....|... ....||.|||||.....|.|.........||.         ..| ....| ...... ..|
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk.........spmeaaeelvdeaiargsed

NT
|.
ni
PP2C Protein phosphatase 2C 67-368 2.3e-91 298.9 In-house 3-255 (255) alignment 
Range on Protein: 67-368
Range on HMM: 3-255/255.0
GPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEpaKVCAAIRKGFLAcHLAMWKKLaewPKTMTg
..|.....||....|| ............||||||||.|||||||||..|||||....|.|| |...|  ||..|.||.||| ......|.   .|..| 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKddfvraVEVTQDHKPELPKERERIEGLGGSVMNksgVNRVVWKrprlthngpvrrstvidqi
.||.||.||.|..|||.|.|||.|||| .||...|..|      .|.|.||||. ..||||||..||||.|   ..||...                   
epsksGstavvalirgkklyvAnvGDSravLcrkdnak......keltedHkpsdedEreRIeeaggsvsn...ngrvngs...................

pfLAVARALGDLWSYDFFsgEFVVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYlmgehgqscAKMLVNRALGRWRQRMLRAD
  |||.|||||.......  |..||.|||.....|... ....||.|||||.....|.|.........||.         ..| ....| ...... ..|
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk.........spmeaaeelvdeaiargsed

NT
|.
ni
0034914 PP2C-like 4-376 6.7e-59 192.1 In-house 18-291 (295) alignment 
Range on Protein: 4-376
Range on HMM: 18-291/295.0
LYSLGVSVFSDQGGRKYMEDVTQIVVepeptaeekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsRCCRRRSSVAFFAV
|..| |.|.|||| ||..||   .|.                                                            ....  .....|.|
llllrvgvasdqGrrksneDavlvvl............................................................nllslledlllfgv

CDGHGGREAAQFAREHLWGFIKKQ----KGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWpktmtGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGi
.||||| .||..|.|.|. .....      ......  .. |.||.|||.. ...... ..        ..|||||.|..||| |.|||.|||| .||  
fDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr.....pelagsGtTavvalirgnklyvanvGDSravll.

QDDpkddfvRAVEVTQDHKPELPKERERIEGLGGSVMNksgvNRVVwkrprlthngpvrrstvidqiPFLAVARALGDLWSY---DFFSGEFVVSPEPDT
 ..      ..| .| ||||  . |||||. .|| |..    .||                      ..||| ||||| . .    ..  |..||.|||.
rng......elvqltvdhkpvnelererilsaggavsh....grvn.....................gvlavtRalGdfdlklllslllleplvsaePdv

SVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKkylmGEHGQSCAKMLVNRALGRWRQrmlraDNTSAIVICIS
.|..|.........|.|||||..............  .|    | . . .|..||..|| |. .     ||....|....
tvleltledddfllLasDGlwdvlsneeivdivrsllak....gldleeaaeeLvdlAlargsr.....DNiTvvvvrln
PPM_PTC7_SpoIIE 66-368 1.3e-56 185.0 In-house 2-230 (230) alignment 
Range on Protein: 66-368
Range on HMM: 2-230/230.0
KGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREaaQFAREHLWGFIKKQKgFTSSEpaKVCAAIRKGFLACHLAMWKKlaewpktmt
.|.|.||..||....||..|||.|...............||||||.  ..|...|........ |...|  |.....|...||.. .....         
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede.........

glPSTSGTTASVVIIRGMK--MYVAHVGDSGVVLGIQdDPKddfvravevtqdhkpelpkERERIeGLGGSVMnK-SGVNRVVWKrprlthngpvrrstv
  ||.||.||.|..|....  .|||..||| ..|  . |..                   ||||| ..|| ..    . .||...               
..psssgaTavvalidpstgklyvanaGdsppllvrd.dgg...................ereri.vagglps.lGilpgrvfgv...............

idqipfLAVARALGDLWSYDffsGEFVVSPEPDtSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKylmgehgqscakmlVNRALGRWRQRM
      |||..| |||. ..    ..||..||| ........|....||.|||||.. .||.......|..||.              ....|... ...
......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp..............aaeglleDDitl

LRADNT
|.....
lvvrvd
PP2Cc_SM00332 13-373 2.2e-56 184.2 In-house 16-274 (274) alignment 
Range on Protein: 13-373
Range on HMM: 16-274/274.0
SDQGGRKYMEDVTQIVVEPEptaeekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrRRSSVAFFAVCDGHGGREA
|.|| || |||....||.                                                                .....||.|.||||| |.
smqgwrksmeDahvvvvdlv.............................................................eeedwlffgvfDGhgGsev

AQFAREHLWGFIKKQKGFTSSE-PAKVCAAIRKGFLACHLAMWKKLAEWPKTMtglpSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDpkddfvrAV
|.|....|. ..|... . ..|   .| .|..|.||... .....   . . .    ..||.||.|..... ..|||.|||| .||. ...       ||
akfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen....alsGstavvallkkedlyvanvGDSravlcrngk.......av

EVTQDHKPELPKERERIEGLGGsvmnksgvnrvvwkrprlthngPVRRSTVIDQipfLAVARALGDLWSY--DfFSGEFVVSPEPDTSVHTLdPQKHKYI
....||||| ..||.||.  ||                       |..  | ..   ||| ||.|| .    .  . | ....|||..|.||  .... .
qlsvdhkpedederkRikkagg......................vvekgrvngg...lavsrafGdhflkknk.klkepyitaepdvkvvtl.tsedefl

ILGSDGLWNMIPPQDAISMCQDQEEKKylMGEHGQSCAKMLVNRALGRwrqrMLRADNTSAIVI
|| |||||... .|...........|.    . .| .|. |.. |. |       .||....|.
ilaSDGlwdvlsnqevvdivrkllakg..ktndpqeaaelldeeairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 96-375 2.6e-41 134.8 In-house 40-280 (282) alignment 
Range on Protein: 96-375
Range on HMM: 40-280/282.0
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGF-----TSSEPAKVCAAIRKGFLACHLAMWKKLaEWPKTMtglpSTSGTTASVVIIRGMKMYVAHV
.. .|||| |||.|.|.|... .|| . | ... .     ..||  .|  |.|.|||| . |. ..  .. ||.      ||.|| .|...  ....|..
kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels.tdlkta....dksGsTavtvlvsekhliianl

GDSGVVLGIQDdpkddfvRAVEVTQDHKPELPKERERIEGLGGSVMnksgVNRVVWKrprlthngpvrrstvidqipfLAVARALGDLWSYD---FFSGE
|||  ||  .        .|.  |.||||. |||..|||  ||||.    |.||  .                     |||.|||||    .     . |
GDsRavlcrng.......kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa.....................LAvsRalGDyeykeeeekkaee

FVVSPEPDTSVHTLDPQKHkYIILGSDGLWNMIPPQDAISMCQDQEEKKylmgEHGQSCAKMLVNRALGRWrqrmlRADNTSAIVICI
  ||.||.. .   . ... ...| .||.| ..  ...... ... |..    .. .. || ||..|| .        || |..|...
qlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva....deleevakalvdkalekg.....srDNlsvlvvlf
0049733 PP2C-like 6-375 3.7e-41 134.0 In-house 2-233 (235) alignment 
Range on Protein: 6-375
Range on HMM: 2-233/235.0
SLGVSVFSDQGG-RKYMEDVTQIvvepeptaeekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrrrsSVAFFAVC
.|.|...||.|  ||..||   .                                                                     ....|||.
rlsvgaasdigrvrkvneDavlv.....................................................................glllfava

DGHGGREAAQFAREHLWGFIKKQkgFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPktmtgLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDdpk
||||| .|...|.|.|. .....  . . .. ....|.|| |||.. |....  ..|       ...||||.|....| |.|||.|||| ..|  ..   
DGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp.....elagmgtTavvalldggklyvanvGDsrayllrdg...

ddfvRAVEVTQDHKPELPKERERIEGLGGSVmnksgvnrvvwkrprlthngpvrrstviDQIPFLAVARALGDLWSYdffsgefvvspePDTSVHTLDPQ
    ..| .|.||.|  . ||.||. .|| |                              .. ||. ||||||.              ||..|..|.|.
....klvqltedhspvnelerqriitaggav............................rvpgrlaltralGdlllk............pdvtvlelepg

KhkYIILGSDGLWNMIPPQDAISMCQDqeekkylmgEHGQSCAKMLVNRALGRWRQrmlraDNTSAIVICI
   ...| |||||..............          . . .|..||..|| |. .     ||....|...
d..flllasDGlwdvlsdeeivdllrs.........ldleeaaerlvelalarggr.....DNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 96-331 1.5e-32 105.9 In-house 34-222 (255) alignment 
Range on Protein: 96-331
Range on HMM: 34-222/255.0
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVcaaIRKGFLACHLAMwkklAEWPktmtglpSTSGTTASVVIIRGMKMYVAHVGDSGV
|   ..|. ||||||.||.|| |.|   ...     ...| |.   ..| . . .. .    .|.|          |||| .|.| . |.|.| |||| |
sdedyyalfdGhgGraaakfaseelykilaelldlnnanPvks...lkkaykeistqi....serp.......kfiGttaasvliiedkvyianvGdsrv

VLGiqddpK-DdfVRAVEVTQDHKPELPKERERIEGLGGSVMNKsgvnrvvwkrprlthngpVRRSTVIDQipfLAVARALGDLwsydfFSGEFVVsPEP
||.     . |    |. .. ||||  ..|..||. ||| |...                  |  | |  .   |||.|||||      |   ||| |.|
vlc.....qkd..gtakrlsldhkPseeseekriselGGtvvst..................vvtsrvnGt...lavsralGds.....flePfvv.pdP

DTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQD
| |      .|.|..||  ||.|..|  ..|...  .
dlsqsleiskkdkflilacdGiwdlisdeeaveivag
subfamily_PPM1E_pd Subfamily PPM1E 96-244 1e-27 90.0 In-house 38-167 (265) alignment 
Range on Protein: 96-244
Range on HMM: 38-167/265.0
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSsEPAkvcAAIRKGFLACHLAMWKKLAEwpKTMtglpsTSGTTASVVIIRGMKMYVAHVGDSGV
.  ||||| ||||| |||..| .||. .. .|. ... .||    |....| ..  .. .| ..  ...     .||.|| ||.|.. ..||| .||| .
keraffavfDGHgGveaakyaaahlhellvrqeklke.dpa...ealkeafkltDerflqkaer..ekl.....ksGstavvvliekdqlyvaWlGDsqa

VLGIQddpkddfVRAVEVTQDHKPELPKERERIEGLGGSVMNKsGVNRV
.|  .       ..||.... |||| ..|..||| .|| |..  |. ||
llvrk.......geavqlmkpHkPeredEkkRieeagGlvvvi.gawRv
subfamily_PPM1G2_pd Subfamily PPM1G2 96-236 2.1e-24 78.9 In-house 50-173 (287) alignment 
Range on Protein: 96-236
Range on HMM: 50-173/287.0
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTssePAKVCAAIRKGFLACHLAMWKKlaewpKTMTGlpSTSGTTASVVIIRGMKMYVAHVGDSGV
.|.|.||| |||||...|..| ..|  .|.|.| |.     ..  .....||..   . |.     ...    ...|.|| ||.|.  |.||| .|||  
kslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.....eklkd..esaGstavvvlikeeklyvanaGDsra

VLGIQDDPKdDFvravevTQDHKPELPKERERIEGLGGSVM
|| .. . |  .      . ||||.  .|..||.  || | 
vlsskgnvk.al......sfDhkPqeesekkriiaagGfve
subfamily_ILKAP_pd Subfamily ILKAP 91-358 2.9e-23 75.5 In-house 36-272 (293) alignment 
Range on Protein: 91-358
Range on HMM: 36-272/293.0
CCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQkgFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLpSTSGTTASVVIIRGMKMYVAHV
 . . |.|...|| |||.|. |..|| |.|   |...  ...|. ..    |.| ..  . .  ... .  .  .      |.|| ||..    .||| .
ekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktdeefLklaskakPv.WkdGstatvvlvldnvlyvanl

GDSGVVLGIQDdPKDDFVRAVEVTQDHKPElpkererieglggsvmnksgvnrVVWKRPRLTHNGPVRRSTVIDQIpfLAVARALGDLWsydfFSGEFvV
|||  ||  .. .. | . .| .|.||.|                           .| |.   | | |   .  .  | |.|..||      | .   |
Gdskavlvrkk.eegdkiasvvLtkdhtpv.......................kyeerkriqkaGgvvrdgrvlGv..levsrsiGdgr....fkrlG.v

SPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEK----KYLMGEHGQSCAKMLVNRALGRW
.  ||..  .|..   ....|  ||||. .  ..... .... |.    . . .| ..| ...  . |  | 
istPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrl
subfamily_PPM1L_pd Subfamily PPM1L 96-332 2.1e-22 72.7 In-house 33-235 (269) alignment 
Range on Protein: 96-332
Range on HMM: 33-235/269.0
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQK-GFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTglpSTSGTTASVVIIRGMKMYVAHVGDSG
 .  |||| |||||  ||.||.. |   ||..   . ..   ..  .  | .    |.. .|| |  |. .    ..|||| . .... .. || |||| 
tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakrae...diaGttalialvqesdlivanvGdsr

VVLgiqddpKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNkSGVNRVvwkrprlthNGpvrrstVidqipfLAVARALGDlwsYDFFSGEFVVsPEP
 ||       |   .|. .. ||||. .||| ||.  || .    || ||         .|      |      ||..|||||   | .   ..|. ..|
Gvl......ydkrGkaiplsfdhkpqqvkerkrikkaGGfiaf.rGvwrv.........aG......v......latsralGd...yplkdknlvi.adp

DTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQ
|     || .| ...|| |||||. .  ..|. . ...
diltfdlddhkpeflilasdGlwdtfsneeavrfiker
PPM_PTC7_motif 310-367 6.1e-20 64.5 In-house 1-50 (51) alignment 
Range on Protein: 310-367
Range on HMM: 1-50/51.0
ILGSDGLWNMIPPQDAISMCQDQEEKKYLmgeHGQSCAKMLVNRALGRWrqrmlRADN
||.|||||.....|.|.....||..||.|   ..|..|..||..||.|.     ..||
iLAsDGLWDvlsdqeavdlvrdqlskkgl...spqeaAeklvdealarg.....seDn
subfamily_PPM1K_pd Subfamily PPM1K 97-338 3e-19 62.2 In-house 30-237 (263) alignment 
Range on Protein: 97-338
Range on HMM: 30-237/263.0
SVAFFAVCDGHGGREAAQFAREHLWGFIKKQKgftsSEPAKVCAAIRKGFLACHLAMWKKLAEW-PKTmtgLPSTSGTTASVVIIR-GMKMYVAHVGDSG
 . ..|| |||.|  ||.|. ..|   .|. .     .  ..   ... |. .. .. . |    ...      .|||||.|...| |... .| .||| 
ellyvavfdGhaGsaaadfvhdklekilkrll....ekekdleivlknafeeldkklkrylefsvaea...ellssGttatvsllrdGtelvlaslGdsr

VVLGIQDDPKddfvravEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVwkrprlthNGpvrRstvidqipfLAVARALGDLwsyDFfsGEFVVSPEP
 .|  . ..|        .|.||.||| .|.|||   ||||  .|  .  |        ||   |         ||..|.||||   |.   .. |  .|
ailcrnGkak.......kltrdhdPeleeekerikaagGsvewnslgkplv........ng...r.........lamtrslGdl...dl..kryGviatP

DTSVHTLDPQKHKYIILGSDGLWNMIPPQ---DAISMCQDQEEKKYL
.|    .| ..  ...| .||. ...  |   | ...|.| ||    
etkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaaha
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 96-279 2e-16 53.4 In-house 18-184 (292) alignment 
Range on Protein: 96-279
Range on HMM: 18-184/292.0
SSVAF-FAVCDGHG--GREAAQFAREHLWGFIKKQKgftsSEPAKVCAAIRKGFLachlamwKKLAEWPKTMTGLPSTSGTTASVVIIRGM-KMYVAHVG
....|  || ||||  |.. ||.| ..|   . .       .  ..  |. .. |       .  |.. |..      ..|..   ..|   ....|.||
ealtflaavldGhGvnGdkvaqlaedtlevellelt....rqlqelsealllril.......diaakldkltidaresattavvcarvrddralilanvG

DSGVVLGIQDDPKDDfvRAVEVTQDHKPELPKERERIEGLGGSVMNkSGVNRVvwkrprlTHNGPVRRSTVIDQIPFLAVARALGDLW
|| ..||      |   . . ...||||| | ||.||   || |   . |           ..|. |     .|   ||..|||||. 
dsrallgrclggsdy..eliPlsrdhkPedPderarilraGGrvep.trvrgw.......gfrGtarvwrrrqqeGdlalsralGdfh
subfamily_PPM1G_pd Subfamily PPM1G 169-242 7.8e-15 47.8 In-house 294-360 (473) alignment 
Range on Protein: 169-242
Range on HMM: 294-360/473.0
STSGTTASVVIIRGMKMYVAHVGDSGVVLGIQddpkddfVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVN
. ||||| |..... |..|| .|||  ||  .        .|...  ||||| ..|.||||  || |     ||
edsGttAvvaLlkekklivAnaGDsRcvlsrn.......GkAldlslDHkPeDevEleRiekAGGkvdedgRvn
subfamily_KAPP-like_pd Subfamily KAPP-like 95-373 1.4e-11 37.0 In-house 31-264 (266) alignment 
Range on Protein: 95-373
Range on HMM: 31-264/266.0
RSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTS-SEPAKVCAAIRKGFLACHLAMWKKLAEWpktmtglpSTSGTTASVVII--RGMKMYVA--H
 | .|.||| ||| |. ||. |.. .   ..|.   |   .  .     .| ..     . .|| ..           |.||.....   | . |.    
csnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdf........eyeGatatlalvwsdGqqrylqvan

VGDSGVVLGIQDDpkddfvrAVEVTQDHKPELPKERERIEGLGGSVMNKSgvNRVvwkrprlthNGpvrrstvidqipfLAVARALGDLWSYDFFSGefv
||||   |   ..       ..|...||| . |.|. ||   | .. ..    |.         ||             |||.||||| .  .   |   
vGdssaflsrGne.......slelskdhkakdpeekqrikddGitlsdnq..tri.........nG.............lavsralGdhfikelniG...

VSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDqeekKYLMGEHGQSCAKMLVNRALgrwrQRMLRADNTSAIVI
.. ||  | . |   ..|..|. |||||..|  .||| . .      |  ..  .. |. |.. |.    | ..  || | ||.
lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks....lydqqatedkmasslletai....qsikakdnvsvivv
subfamily_PPM1E_pd Subfamily PPM1E 269-375 9.5e-11 34.4 In-house 171-262 (265) alignment 
Range on Protein: 269-375
Range on HMM: 171-262/265.0
LAVARALGDLWSYDFfsgefvVSPEPDTSVHTLDpQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKkylMGEHGQSCAKMLVNRALGRWrqrmlRADNT
|.|.||.||  . ..      || |.|..  .|| ....|.||..||||........... ..  ..     |. .. ||.||. |  .       .|| 
LsvsRaiGDvklkpy......vsgeadvaeveld.gseeylilacDGlwDvvneeevvklveeflad...gaedlsevakllveaakeag.....ssDni

SAIVICI
...|. .
tvvvvfl
subfamily_PPM1G2_pd Subfamily PPM1G2 269-375 2.5e-10 32.8 In-house 181-286 (287) alignment 
Range on Protein: 269-375
Range on HMM: 181-286/287.0
LAVARALGDLWSYDFF---SGEFVVSPEPDTSVHTLDpQKHKYIILGSDGLWNMIPPQDAISMCQDQeekkYLMGEHGQSCAKMLVNRALGRWRQ-RMLR
||..|||||    .     . | .|  .||  |. || ... ...|  ||.|...  .. . ... .      .| . .. .. |....| .  .   . 
LalsralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrer....lvsgakldeiieelldkclapdssntgvG

ADNTSAIVICI
.|| .......
cDnmtvvivvl
subfamily_PPM1G_pd Subfamily PPM1G 97-152 5.6e-10 31.8 In-house 46-98 (473) alignment 
Range on Protein: 97-152
Range on HMM: 46-98/473.0
SVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSepaKVCAAIRKGFLACHLA
 ...||| |||||.| |..  ..| ...|.|||.      .| .|... |||.   
dtslfavyDGHGGkevakyvakklpdllkaqkgykeg...dvekaleeaflalDek
PPM_PTC7_SpoIIE_motif 298-375 5.2e-09 29.7 In-house 4-80 (81) alignment 
Range on Protein: 298-375
Range on HMM: 4-80/81.0
VHTLDPQKHKYIILGSDGLW-------NMIPPQDAISMCQDQeeK--KylmgehGQSCAKMLVNRALGrwRQRMLRADNTSAIVICI
..... ..   ..|..|||.       ...............  .  .       |..|..||...|   .... |.|... .|...
eaefqLkpgdvllLyTDGltEardsdgelfgkeellrladra..egks......lqeladklvdevle..ngsgereDDitllvlrv
subfamily_PDP_pd Subfamily PDP 137-229 5.9e-09 28.5 In-house 114-208 (398) alignment 
Range on Protein: 137-229
Range on HMM: 114-208/398.0
KVCAAIRKGFLACHLAMWKK-LAEWPKTM---TGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDdfVRAVEVTQDHKPELPKERERIE
||. |..|.|| .   . .. |.. ....   . |...||..| .. |.| ...|| .||.  ||| |..     . ||....|.  . ..| |||.
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegs..weavkLskdqtadneeEveRik
PP2C_SIG_SM00331 100-372 2.3e-08 26.8 In-house 32-214 (217) alignment 
Range on Protein: 100-372
Range on HMM: 32-214/217.0
FFAVCDGHG-GREAAQFAREHLWGFIKKQKG--FTSSEPAKVCAAIRKGflachlamwkklaewpktmtGLPSTSGTTASVVII--RGMKMYVAHVGDSG
...|.||.| | .|| .... .  . .  .    .|. . ... ||..                        . ...|. . ..  .. |...|..||| 
llvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....................keekgmfaTlllalydfssgklsyanaGdsr

VVLGIqddpKDDFVR---AvevtqdhkpelpkererieglggsvmnksgvnrvvwkrprlthngpvrrstvidqipflavaralgdlwsydffSGEFVVS
..|      ... |    .                                                                             ....
pyllr....dgklveilkd..........................................................................vegaplG

PEPDTS--VHTLDPQKHKYIILGSDGLWNMIPPQDaismcQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRA---DNTSAIV
 ||. |  ...|. .|   ..| .|||...  ...      ..|. . .. .. .|.|. | .. . .  ... ..   |. . .|
lepevsvdirelelekgdllllytDGltearsekg.....faeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 265-373 1.2e-07 23.9 In-house 177-274 (276) alignment 
Range on Protein: 265-373
Range on HMM: 177-274/276.0
QIPFLAVARALGDLWSYDFFSGefvVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDqeekKYLMGEHGQSCAKMLVNRALgrwrQRMLR
.|  |||.||||| .  .   |   .. ||  | . |   ..|..|. |||||..|  .||| . .      |  ..  .. |. |.. |.    | .. 
rinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks....lydqqatedkmasslletai....qsika

ADNTSAIVI
 || | ||.
kdnvsvivv
subfamily_PDP_pd Subfamily PDP 290-352 1.8e-07 23.6 In-house 270-331 (398) alignment 
Range on Protein: 290-352
Range on HMM: 270-331/398.0
VSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVN
.. ||.   | | ..  |...|..||||... .....|. ..  .||    . ... ||. ..
ltaePevtshklren.dkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlk
subfamily_TAB1_pd Subfamily TAB1 171-232 8.7e-07 21.0 In-house 129-186 (333) alignment 
Range on Protein: 171-232
Range on HMM: 129-186/333.0
SGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDpkddFVRAVEVTQDHKPELPKERERIEGLG
 |||| |..|   |.||| ||||  .|  . .    . . . . .||. . ..| .|...||
gGttAvvalifnnkLyVaNvGdsrAllvkrke....sekvkqLsvdHttdNedEllRlkdLG
PP2C_2 Protein phosphatase 2C 94-199 3.5e-06 19.4 Pfam-A 20-125 (212) alignment 
Range on Protein: 94-199
Range on HMM: 20-125/212.0
RRSSVAFFAVCDGHGG----REAAQFAREHLWGFIKKQKgfT--SSE-PAKVCAAIRKGFLACHLamwkKLAEW--PktmTGLPSTSGTTASVVIIRGMK
. |.. ..||.||.|     ...|..| | .   ..|.   .  | .  .... .|... ||       . .|          ..  .|| ....|.. .
easdgwllaVADGaGsakrSdkGarlaveaagealekll..eeeseqeeeallrqieneilasvk....lkqeaeaq...qeelkdyatTlllavitpge

MYVAHVGDSGVVLGI
......||...|.  
ivffqiGDgaivvrd
PP2C_2 Protein phosphatase 2C 94-199 3.5e-06 19.4 In-house 20-125 (212) alignment 
Range on Protein: 94-199
Range on HMM: 20-125/212.0
RRSSVAFFAVCDGHGG----REAAQFAREHLWGFIKKQKgfT--SSE-PAKVCAAIRKGFLACHLamwkKLAEW--PktmTGLPSTSGTTASVVIIRGMK
. |.. ..||.||.|     ...|..| | .   ..|.   .  | .  .... .|... ||       . .|          ..  .|| ....|.. .
easdgwllaVADGaGsakrSdkGarlaveaagealekll..eeeseqeeeallrqieneilasvk....lkqeaeaq...qeelkdyatTlllavitpge

MYVAHVGDSGVVLGI
......||...|.  
ivffqiGDgaivvrd