Gene PPM1E in Homo sapiens

Synonym: CaMKP-N, POPX1, PP2CH, caMKN, PPM1E

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP178_AA protein Get Run
HsapP178_AA_226-491 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 229-490 1.5e-133 437.0 In-house 3-263 (265) alignment 
Range on Protein: 229-490
Range on HMM: 3-263/265.0
YYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRC
.||.||.|.||.||||||.||...|.|.||.|.|..|.|.||||||||||.|| ||. ||| .|||||....||||||..||..|||||.|||.||.|..
eyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklks

GTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTED
|.|.||..|....|.|||.||||..|||||.||.|||||||.|||||.|||..||.||..|||||||.|||||||||...|||..|.|| |.. |||.|.
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsee

YLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLrD
||||||||..|.||..|.||.|...|.....|.|.||..||..|..|||||||||.|||| |
ylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl.d
0034914 PP2C-like 227-491 1.4e-72 236.8 In-house 18-293 (295) alignment 
Range on Protein: 227-491
Range on HMM: 18-293/295.0
QLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNledqeEQAYFAVFDGHGGVDAAIYASIHLHVNLVR--------QEMFPHDPAEALCRAFRVTDERFV
 |..  ... ....|...|| .........|..     ....|.||||||| .|| .|| .|. .|..         .....|..||| .||  .||...
llllrvgvasdqGrrksneDavlvvlnllslle.....dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeell

QKAAR--ESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWfgaWRVNGSLSVSRAIGDAEHK-------
..| .  | ...||| || .||||.|.||.||||...|.|.|..| | . |||..|.|..||...||.|..   .||||.| |.||.|| ..|       
elallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslll

--PYICGDADSASTVLD-GTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDM
  |..    |  .. |. .  |.|.||.||..|.....|.|..|...|. .. | ...|..||  | ..||.|||||.||.|...
leplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
PP2Cc_SM00332 227-486 3e-68 223.2 In-house 9-274 (274) alignment 
Range on Protein: 227-486
Range on HMM: 9-274/274.0
QLYYETsiHAIKNMRRKMEDKHVCIPDFNmlfnleDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD-----PAEALCRAFRVTDERFVQKA
.| | .  .. ...|..||| ||...|..       .|. ..|.||||||| ..| ..| .|. .| ..  .  |     ..||| .||. |||......
glsygk..ssmqgwrksmeDahvvvvdlv......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

ARESL---RCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGcvvWFGAWRVNGSLSVSRAIGDAEHK-------PY
 .. |   ..|.| || ..... |.||.||||...|.|.|.||.| . |||..|||..||.. ||   .   .||||.|.||||.|| . |       ||
qskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg...vvekgrvngglavsrafGdhflkknkklkepy

ICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHL-KENNGDSSMVAHKLVASARDA-GSSDNITVIVV
|  . |   . |.  .. ||||.|| .| ....|.|..| ..| |... | . .| .|.. |... ||.|||||.||
itaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 233-481 8e-67 218.5 Pfam-A 4-255 (255) alignment 
Range on Protein: 233-481
Range on HMM: 4-255/255.0
SIHAIKNMRRKMEDKHVCIPDFNMLfnlEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD--PAEALCRAFRV-TDERFVQKAAR-ESLRC
. ......|..|||.|.......     ..... |.||||||||| .|| ||. ||.  | .|..|. .    .|| ..|.  |||.. ...|. | ...
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks

GTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAV-ELMKPHKPDREDEKQRIEALGGCVVWfgAWRVNGSLSVSRAIGDAEHKP----YICGDADSASTVL
|.| ||..|||. |.||.||||...|.||..|. ||.. |||..|||..|||..|| | .   .||||||.||||.|| | ||    ..  . |. |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl

DGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNgDSSMVAHKLVASARDAGSSDNI
.  ...||||.||..| ....||| .| ..|.... . ...| .||  | . ||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 233-481 8e-67 218.5 In-house 4-255 (255) alignment 
Range on Protein: 233-481
Range on HMM: 4-255/255.0
SIHAIKNMRRKMEDKHVCIPDFNMLfnlEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD--PAEALCRAFRV-TDERFVQKAAR-ESLRC
. ......|..|||.|.......     ..... |.||||||||| .|| ||. ||.  | .|..|. .    .|| ..|.  |||.. ...|. | ...
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks

GTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAV-ELMKPHKPDREDEKQRIEALGGCVVWfgAWRVNGSLSVSRAIGDAEHKP----YICGDADSASTVL
|.| ||..|||. |.||.||||...|.||..|. ||.. |||..|||..|||..|| | .   .||||||.||||.|| | ||    ..  . |. |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl

DGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNgDSSMVAHKLVASARDAGSSDNI
.  ...||||.||..| ....||| .| ..|.... . ...| .||  | . ||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PPM_PTC7 233-481 6.1e-65 212.2 In-house 4-259 (259) alignment 
Range on Protein: 233-481
Range on HMM: 4-259/259.0
SIHAIKNMRRKMEDKHVCIPDFNMLfnlEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD--PAEALCRAFRV--TDERFVQKAAR-ESLR
. .|... |..|||.|.. ....     ..... |.|||||||||  || ||. ||.  | ....|. .  . .||  .|.   |||.. ...|. |...
gasafqgfrksmedahialanless...sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepst

CGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAV-ELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKP------YICGDADSAS
.|.| || .|.|. |.||.||||...|.|.|.|| .| . |||..|||..|||..|| | . | .||||.| ||||.|| | ||      ..  . |  |
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdiss

TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENngDSSMVAHKLVASARDAGSSDNI
| .|  ...||||.||..| |...||| .| ..|...  | ...| |||  | . ||.|||
tkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
subfamily_PPM1A_pd Subfamily PPM1A 230-488 6.8e-58 189.2 In-house 12-280 (282) alignment 
Range on Protein: 230-488
Range on HMM: 12-280/282.0
YETSIHAIKNMRRKMEDKHVCIPDFNmlfnleDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMF---------PHDPAEALCRAFRVTDERFVQK
.  .. . ...|..|||.|... ...       ......|||||||.| ..| |.. ||. |....| .          ..  ||| ..|  .||.  ..
lrygvssmqgwrvemEDahtvvaslg......alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel

AARES--LRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVwfgAWRVNGSLSVSRAIGDAEHKP--------
 .. .  ...|.| |. ... . | .| .|||  .|.|.|.|. | . |||.|..||.|||. || ||     ||||.| ||||.|| | |         
stdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaee

-YICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENnGDSSMVAHKLVASARDAGSSDNITVIVVFL
  . .... .|.  .  .|.|.||||| .|... .|.|..| ..|. .  . ..||..||  |  .|| ||..|.||..
qlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlf
0049733 PP2C-like 235-489 1.4e-54 177.8 In-house 8-234 (235) alignment 
Range on Protein: 235-489
Range on HMM: 8-234/235.0
HAIK-NMRRKMEDKHVCipdfnmlfnledqeEQAYFAVFDGHGGVDAAIYASIHLHVNLVR--QEMFPHDPAEALCRAFRVTDERFVQKAAR--ESLRCG
. .. ..|. .|| ...              ....|||.|||||  |. .|| .|. .|..  .|....|..||| .||. ..|.....| .  |  ..|
asdigrvrkvneDavlv..............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

TTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVvwfgawRVNGSLSVSRAIGDAEHKpyicgdADSASTVLDGTEdY
|| || ...|..|.||.|||| ..|.|.|..| | ..|.| .|.|.|||...|| |      ||.|.| ..||.|| ..|      .|  .. |.  . .
tTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlelepgd.f

LILACDGFYDTVNPDEAVKVVSDhlkennGDSSMVAHKLVASARDAGSSDNITVIVVFLR
|.||.||..| ....|.|.....       | ...|..||  |...|. |||||.||.|.
lllasDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 239-488 9.8e-51 165.5 In-house 15-253 (255) alignment 
Range on Protein: 239-488
Range on HMM: 15-253/255.0
NMRRKMEDKHVCIPDFNmlfnleDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ-EMFPHDPAEALCRAFRVTDERFvqkaAR-EsLRCGTTGVVTF
  |  |||. |    |.      |.... |.|.|||||| .|| .|| .|.  |    .... .| ..| .|.. .. ..    .     ..||| .. .
GrrptmedelviyGsfr......dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serp.kfiGttaasvl

IRGNMLHVAWVGDSQVMLV-RKGQAVELMKPHKPDREDEKQRIEALGGCVVWF-GAWRVNGSLSVSRAIGDAEHKPYICGDADSA-STVLDGTEDYLILA
| ...  .| ||||.|.|  ..| |. |   |||  |.|..||..||| ||    . |||| |.||||.||.  .|..  | |   |     .. .||||
iiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflila

CDGFYDTVNPDEAVKVVSdhlkeNNGDSSMVAHKLVASARDAGSSDNITVIVVFL
||| .| .  .|||..|      .  |.   | ||   |   ||.|||.|||. |
cdGiwdlisdeeaveiva.....gisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1G2_pd Subfamily PPM1G2 233-488 2.2e-47 154.4 In-house 22-286 (287) alignment 
Range on Protein: 233-488
Range on HMM: 22-286/287.0
SIHAIKNMRRKMEDKHVCIPDfnmLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPA-EALCRAFRVTDERFVQKAARESLRCGTT
.  |..  |..||| |.  ..   |....|... |.||||||||| ..| ||. .|.  ..... | ..   ..|  ||  ||| .... . .   .|.|
gssamqGyrlnmeDahilene...lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaGst

GVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVwfgAWRVNGSLSVSRAIGDAEHKPYI-CGDA--------DSASTV
 ||. |. . | || .|||. .|  ||..  |   |||..|.||.||.| || |      ||||.|..|||.|| |.|     .          |   . 
avvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkk

LDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENnGDSSMVAHKLVASARDAGSS------DNITVIVVFL
||  ...|.||||| .| .. .| |..|  .|...  . . ....|. ..    ||      ||.||..| |
ldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1L_pd Subfamily PPM1L 231-489 2.4e-43 141.4 In-house 6-267 (269) alignment 
Range on Protein: 231-489
Range on HMM: 6-267/269.0
ETSIHAIKNMRRKMEDKhvcipdFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ---------EMFPHDPAEALCRAFRVTDERFVQKA
........  | .|||.      |..  ..... .. .|||||||||  || .|   |  .. ..         .  | . .. |       ||....||
qvavysvlGrrprmedr......feieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklleka

ARESLRCGTTGVVTFIRGNMLHVAWVGDSQ-VMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAE--HKPYICGDADS
 |.    ||| ........ | || ||||. |.  ..|.|. |   ||| .  |..||.  || . . |.|||.| |..|||.||    .|  .  | | 
kraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdi

ASTVLDGT-EDYLILACDGFYDTVNPDEAVKVVSDHLKENNgdssMVAHKLVASARDAGSSDNITVIVVFLR
 .  ||    ..||||.||..||   .|||. . ..||| .    . |. ||  .   || |||||.|| |.
ltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd....fGakslvlesfkrGsvdnitvlvvklk
subfamily_ILKAP_pd Subfamily ILKAP 237-487 1.7e-40 132.0 In-house 12-291 (293) alignment 
Range on Protein: 237-487
Range on HMM: 12-291/293.0
IKNMRRKMEDKHVCIPDFNMLFNLEDQ--EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQemFPH--------DPAEALCRAFRVTDERFVQKAARE--
 |  | .|.|.|| . |..   .||..  .  .|.||||||.|  |. .|. .|| .....  .|.        .   .|  .|. ||| |...|...  
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktdeefLklaskakP

SLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQ------AVELMKPHKPDREDEKQRIEALGGCVvWFGawRVNGSLSVSRAIGDAEHKPY-ICGDAD
. . |.| .| ..  |.|.|| .|||. .|||| .      .| | | |.| ...|..||.  || | . |  ||.| | |||.||| ..|   .    |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdg..rvlGvlevsrsiGdgrfkrlGvistPd

SASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKEN-----------NGDS----SMVAHKLVASARDAGSSDNITVIVVF
     |.  . ...|||||...... ||.|| ... |...           . ..     .....| . |   |||||.||..| 
vkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
subfamily_PPM1K_pd Subfamily PPM1K 263-491 2.3e-38 124.8 In-house 28-261 (263) alignment 
Range on Protein: 263-491
Range on HMM: 28-261/263.0
QEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKA-----ARESLRCGTTGVVTFIR-GNMLHVAWVGDSQVMLVR
..|  |.||||||.|. || ..  .|.  | |     .|  . | .||   |... . .      .| |  |||  |...| |. | .| .|||. .| |
dpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcr

KGQAVELMKPHKPDREDEKQRIEALGGCVVW--FGAWRVNGSLSVSRAIGDAEHKPY-ICGDADSASTVL-DGTEDYLILACDGFYDTVNPDEAVKVVSD
.|.|  | . |.|..|.||.|| | || | |   |  .||| |...|..|| . |.| .  . .. |  .  ... .|.|  ||  . ||  |  ..|. 
nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl

HLkenngDSSMVAHKLVASARDAGSSDNITVIVVFLRDM
       |    || |.  | . || || |..|| |.  
ch.....dpeeaahalteqalqygsednatavvvplgaw
subfamily_PPM1D_pd Subfamily PPM1D 238-489 4e-33 107.8 In-house 10-308 (309) alignment 
Range on Protein: 238-489
Range on HMM: 10-308/309.0
KNMRRKMEDKHVCIPDFNMLFNledQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAE----ALCRAFRVTDERF-------VQKAARESL
.  |. |||  .   . .   .   . |.|..|||||||| .|| .|. ||  .. .|. |  .. |    |. .||  | |         ....  .  
qGgrkymeDvvaivleeeesae...elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksglls

RCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQ------AVELMKPHKPDREDEKQRIEALGGCVVWF-GAWR---------VNGS--------LSVSRA
  |||  | .||.. |.|| ||||...|  | .      | ||.| |||.  .||.||| ||| |    |  |          ||         |.|.|.
taGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRs

IGD-----AEHKPYICG-DADSASTVLDGTED-YLILACDGFYDTVNPDEAVKVVSDHLKENNG---DSSMVAHKLVASARDAGSS-----DNITVIVVF
.||     |. . ..   . |   ..||. |. ..||| ||... ..|..||.||... . .      |. ||..|| .| .  .|     ||..||||.
lGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvivvi

LR
|.
le
PPM_PTC7_SpoIIE 233-485 6e-33 107.6 In-house 4-226 (230) alignment 
Range on Protein: 233-485
Range on HMM: 4-226/230.0
SIHAIKNMRRKMEDKHVCIPDFNMLfnlEDQEEQAYFAVFDGHGGVDaaIYASIHLHVNLVRQEmFPHD--PAEALCRAFRVTDERFVQKaareSLRCGT
. .|... |..|||.|.. ....      ..   ......|||||     .|. .|.  | ..  |.    |.|.| |...  . ..  .       .|.
gasaaqgarksmedahispanseks...sggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssga

TGVVTFIRGNM--LHVAWVGDSQVMLVRK-GQavelmkphkpdredEKQRIeALGGCV-VWFGAWRVNGSLSVSRAIGDAEHKP---YICGDADSASTVL
| ||  |...   |.||..||| ..|||. |.              |. || ..|| . . .. .||.|.|.||.|.||   ..   ..   .|.  . |
TavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel

DGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENngdssmvahklvasARDAGSSDNITVIV
.| ...||||.||..| ..|.|.|  | |.|...              | ... .| ||..|
fgkdeflilasdglwdvlspqelvdlvrdelekp..............aaeglleDDitllv
subfamily_PPM1G_pd Subfamily PPM1G 327-490 1.9e-28 92.7 In-house 295-472 (473) alignment 
Range on Protein: 327-490
Range on HMM: 295-472/473.0
RCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGawRVNGSLSVSRAIGDAEHKP---------YICGDAD
  ||| ||. .... | || .|||  .| |.|.|..|   |||. | |..|||. || |   |  |||| | .|||.||   |           |    |
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPD

SASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGD-SSMVAHKLVA-----SA-RDAGSSDNITVIVVFLRD
   ..|   ...|.||||| ..... .| |  | ..||... .  | . ..|.      .   |    || |||.| |..
ikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_KAPP-like_pd Subfamily KAPP-like 242-488 5e-24 77.7 In-house 10-266 (266) alignment 
Range on Protein: 242-488
Range on HMM: 10-266/266.0
RKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLvRQEMF----------PHDPAEALCRAFRVTDERFvQKAAREslRCGTT
 .||| ...|  .    .| .  . | ||||||| |  ||  |.  .  .|  . .            .|  . |  ||.  |... ..   |   . .|
temedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkel.ekllkstkqddGGdniydqskllenafkevdakl.kdfeye..Gatat

GVVTFI--RGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGgCVVWFGAWRVNGsLSVSRAIGDAEHKPYICGDAD----SASTVLDG
 .. .   .  .| || ||||  .| |  ...|| | || . ..|||||   |   .  .  |.|| | ||||.||   |   .| .     |   .|  
lalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltp

TEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFL
 ...||.| ||..| .. ..|...|.    ... . .| .  | .. . . . ||..|||| |
fdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 268-406 3e-20 65.9 In-house 21-183 (292) alignment 
Range on Protein: 268-406
Range on HMM: 21-183/292.0
YF--AVFDGHG--GVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGN-MLHVAWVGDSQVMLVR-----K
 |  ||.||||  |   | .|  .| |.|.       . .|||      .  .. .  . . ....|. | . .| .  | .| ||||...| |     .
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GQAVELMKPHKPDREDEKQRIEALGGCVV--------WFGAWRV------NGSLSVSRAIGDA
 . . | . |||.  ||..|| . || |         . |. ||      .| |..|||.|| 
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 341-488 5.7e-19 61.0 In-house 127-276 (276) alignment 
Range on Protein: 341-488
Range on HMM: 127-276/276.0
MLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGgCVVWFGAWRVNGsLSVSRAIGDAEHKPYICGDAD----SASTVLDGTEDYLILACDG
 | || ||||  .| |  ...|| | || .  .|||||   |   .  .  |.|| | ||||.||   |   .| .     |   .|   ...||.| ||
ylqvanvGdssaflsrGneslelskdhkatdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

FYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFL
..| .. ..|...|.    ... . .| .  | .. . . . ||..|||| |
lwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
PP2C_SIG_SM00331 253-487 1.1e-16 54.1 In-house 19-216 (217) alignment 
Range on Protein: 253-487
Range on HMM: 19-216/217.0
DFNMLFNLEDQeeQAYFAVFDGHG-GVDAAIYASIHlhVNLVRQEMFP-HDPAEALCRAFRVTDERfvqkaaRESLRCGTTGVVTFI--RGNMLHVAWVG
|.  .. |...  .  ..|.||.| |..|| ..|    ....|...   .....|| |. |. .|.       |  . ..| ... .  ... |..| .|
Dyydvvklneg..rlllvvaDgmGkGlaAaaassql..rtalrellsegeelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaG

DSQVMLVRKGQAVELMKPhkpdredekqriealggcvvwfgawrvngslSVSRAIGDAEHKPyicgdADSASTVLDGtEDYLILACDGFYDTVNPDE---
|| . |.|.|. ||  |                                  ....|  .. .     .|.... |.  .| |.|. ||  . .....   
dsrpyllrdgklveilkd...............................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfae

--AVKVVSDHLKENNGDSSM-VAHKLVASARDAGSSDNITVIVVF
    ... |....   . .     .|...|.... .|.|||.||.
erleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PP2D1_pd Subfamily PP2D1 336-455 9.1e-16 50.6 In-house 184-307 (492) alignment 
Range on Protein: 336-455
Range on HMM: 184-307/492.0
FIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGA-WRVNGSLSVSRA---IGDAEHKPYICGDADSASTVLDGTEDYLI
 .   .|..| .|. | .|.|.|.|. | . | |  . |..|.|  |. ||  .   .||| |.. |    .|| . |  .  .    |. || .  .|.
leelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflv

LACDGFYDTVNPDEAVKVVSDHLK
||  | .. .. .| ...| . |.
lAsnGlWevlseeevlsLvkqtla
subfamily_PHLPP_pd Subfamily PHLPP 340-488 2.5e-15 49.1 In-house 105-245 (246) alignment 
Range on Protein: 340-488
Range on HMM: 105-245/246.0
NMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREdEKQRIEALGGCVVwfGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYD
 .|.|| ||  | .|.|.|. . | |... ... | .||    . .      ..|| .. .| .|     |..  .    ...|   ...||.  . ...
fsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiit..ednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWe

TVNPDEAVKVVsdhlkENNGDSSMVAHKLVASARDAGSSDNITVIVVFL
... ||||. |      .. |. ..| |||  |   | .|...|.|| |
vlsideaveav.....rkeedplvaAkklvdlaqsygaadsvsvlvvrl
Subfamily Dicty-PPM1L-like 372-489 1.2e-14 46.8 In-house 180-304 (305) alignment 
Range on Protein: 372-489
Range on HMM: 180-304/305.0
EDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTED-YLILACDGFYDTVNPDEAVKVVSDHLKENNGD------SSMV
.... ||| |..... .|  .||. |..|| .|| . | ..  . ||   |.  ..| .|.|| || .. .. .. |. | . |...  .         .
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei

AHKLVASARDAGSSDNITVIVVFLR
 .  |  |   || ||||.....|.
srviveeavkrgsgDnitlviiklk
PPM_PTC7_motif 431-481 9e-12 38.3 In-house 1-51 (51) alignment 
Range on Protein: 431-481
Range on HMM: 1-51/51.0
ILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNI
|||.||..| ....||| .| |.|......  ..| |||  |.  ||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PPM1G_pd Subfamily PPM1G 235-326 1.5e-11 37.0 In-house 24-108 (473) alignment 
Range on Protein: 235-326
Range on HMM: 24-108/473.0
HAIKNMRRKMEDKHVCIPDFnmlfnledQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD-PAEALCRAFRVTDERFVQKAARESL
 | .  | ..|| | ||.|.        .|. . |||.||||| . | | . .|   |  |. . ..  ..||. ||   ||. ..... . |
samqGwrvsqEDahncitdl........dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkaeeslkel
subfamily_TAB1_pd Subfamily TAB1 324-409 5.5e-11 34.8 In-house 125-213 (333) alignment 
Range on Protein: 324-409
Range on HMM: 125-213/333.0
ESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVR---KGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK
| .. ||| ||  |  | |.|| ||||. .||.   . . . | . |. | ||| .|.. ||  .      .. ||    |.||| . |
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvk
subfamily_PDP_pd Subfamily PDP 410-471 1.3e-08 27.3 In-house 268-329 (398) alignment 
Range on Protein: 410-471
Range on HMM: 268-329/398.0
PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVAS
||.  . .  |  |  .. .|.|| || .|.....|.|..|..||.... .... ...  ..
PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeaklt
PPM_PTC7_SpoIIE_motif 427-486 4.5e-08 26.7 In-house 12-78 (81) alignment 
Range on Protein: 427-486
Range on HMM: 12-78/81.0
EDYLILACDGFY-------DTVNPDEAVKVVSDHlkENNGdSSMVAHKLVASARDAG---SSDNITVIVV
 | |.|..|| .       ......|........  | ..    .|.|||.... .|   ..|.||..|.
gdvllLyTDGltEardsdgelfgkeellrladra..egks.lqeladklvdevlengsgereDDitllvl
subfamily_PPM1H_pd Subfamily PPM1H 305-381 2.3e-07 22.9 In-house 139-213 (404) alignment 
Range on Protein: 305-381
Range on HMM: 139-213/404.0
ALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPdrEDEKQRIEAL
||  ||   ||   .   .  .. | | .|. .  . |.||  |||. .||||.. ..| . . |  | |.||.  |
alesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRlqel
subfamily_PP2D1_pd Subfamily PP2D1 461-489 1.6e-06 20.1 In-house 462-490 (492) alignment 
Range on Protein: 461-489
Range on HMM: 462-490/492.0
SSMVAHKLVASARDAGSSDNITVIVVFLR
  .....|| ||  ||| |||||.|..|.
AealserlvqsALlAGsrDnitvmvilLk
subfamily_PPTC7_pd Subfamily PPTC7 426-481 1.7e-06 20.6 In-house 166-221 (252) alignment 
Range on Protein: 426-481
Range on HMM: 166-221/252.0
TEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNI
..| ..|| ||..| . .|| ......  .... .  ..|.||.. ||  . . ..
kgDiivlatDGlfDNlledeileilkelkeseksslqslakklaekarelsldpey
Subfamily Dicty-PPM1L-like 236-293 2.6e-06 19.5 In-house 13-63 (305) alignment 
Range on Protein: 236-293
Range on HMM: 13-63/305.0
AIKNMRRKMEDKHvcipdfNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLhVNLV
. .| |.. ||..      .    ||...|. .| |||||.|  || |.  .| |..|
vsansrkyqedrn......kvkislessqelslfGvfdGhnGdiaaeyvkkkl.veiv
subfamily_PP2D1_pd Subfamily PP2D1 239-295 6.5e-06 18.1 In-house 10-62 (492) alignment 
Range on Protein: 239-295
Range on HMM: 10-62/492.0
NMRRK--MEDKHVCIPDFNmlfnleDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ
| | |  ||||..   .|       .. ....|...||. |  ||  |. .||. |...
nsrWKskmeDkrtlqdyfg......ndvnscFfgiyDGynGataAeiaakelhevllee
subfamily_PPM1H_pd Subfamily PPM1H 261-294 7.7e-06 17.9 In-house 57-90 (404) alignment 
Range on Protein: 261-294
Range on HMM: 57-90/404.0
EDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVR
|.. . |||..||||.|  ||. ||  ||  | .
eeklplayfglfDGhaGsgaalvaskllhkhlke
subfamily_PDP_pd Subfamily PDP 314-409 8.3e-06 18.1 In-house 139-241 (398) alignment 
Range on Protein: 314-409
Range on HMM: 139-241/398.0
DERFVQKAARESlRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRK---G--QAVELMKPHKPDREDEKQRIEALG-----GCVVWFGawRVNGSLSVSRAI
.|. ...|.. .   |.. ....|.|. |||| .||.. .| ..   |  .||.| | .  | |.| .||..         |.  |  |. |.|  .|| 
kekslreallva.lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirng..RlLgeLqPlRAF

GDAEHK
||...|
GdvryK