Gene PPM1F in Homo sapiens

Synonym: CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2, PPM1F

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP179_AA protein Get Run
HsapP179_AA_150-416 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 153-416 7.2e-127 415.0 In-house 2-264 (265) alignment 
Range on Protein: 153-416
Range on HMM: 2-264/265.0
RQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQ
... |||.|..|.|||||||||.|...|.||.|.|  .||.||||||||||.||.|||.|.|....||..|..||. ||.|||..||..||.||.||.|.
seyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklk

SGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSE
||.|.|..||....|.||||||||..||..|..|.||.||.|||.|||.|||..||.| ....|||||.|.|||||||| .|||||||||.|. .|.|||
sGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgse

DYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLrDP
.||.|||||..|||...||| ||...|......  .||..||.||.|.||.|||||.|||| ||
eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl.dp
PPM_PTC7 158-406 7.8e-76 247.9 In-house 4-259 (259) alignment 
Range on Protein: 158-406
Range on HMM: 4-259/259.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR--TDQMFLRKAKR-ERLQ
. .|... |..|||.|..|. ...    |.  ..|.|||||||||  ||.||. |... ..........  .| |||..|..  ||... ..... | ..
gasafqgfrksmedahialanless...sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepst

SGTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKP------YVSGEADAAS
||.| |.||| | .|.||..|||...|...|..| .| | |.|...||..|||..||.||.....||||.||||||.||...||      .|| | |  |
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdiss

RALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgSGLRVAEELVAAARERGSHDNI
.... ....|.||.||..|||..||.| ||.|.|  .  .  ..||.||  | .|||.|||
tkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 158-406 1.1e-75 247.6 Pfam-A 4-255 (255) alignment 
Range on Protein: 158-406
Range on HMM: 4-255/255.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR-TDQMFLRKAKR-ERLQS
. ..... |..|||.|..|.....    |.  ..|.||||||||| .||.||. |... ...|......   | |||..|.. ||... ..... | ..|
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks

GTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHmdCWRVNGTLAVSRAIGDVFQKP----YVSGEADAASRAL
|.| |.||| | .|.||..|||...|..... . .|.| |.|...||..|||..||.||.  ..||||.||||||.||...||    .|| | |  |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl

TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSHDNI
| ....|.||.||..||...||.| ||.|.|. .. |  ..|||||  | .|||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 158-406 1.1e-75 247.6 In-house 4-255 (255) alignment 
Range on Protein: 158-406
Range on HMM: 4-255/255.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR-TDQMFLRKAKR-ERLQS
. ..... |..|||.|..|.....    |.  ..|.||||||||| .||.||. |... ...|......   | |||..|.. ||... ..... | ..|
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks

GTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHmdCWRVNGTLAVSRAIGDVFQKP----YVSGEADAASRAL
|.| |.||| | .|.||..|||...|..... . .|.| |.|...||..|||..||.||.  ..||||.||||||.||...||    .|| | |  |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl

TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSHDNI
| ....|.||.||..||...||.| ||.|.|. .. |  ..|||||  | .|||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
0034914 PP2C-like 151-416 1e-71 234.0 In-house 17-293 (295) alignment 
Range on Protein: 151-416
Range on HMM: 17-293/295.0
SQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGlsdpvNRAYFAVFDGHGGVDAARYAAVHVHTNAAR--------QPELPTDPEGALREAFRRTDQMF
.  .. |... ... |...||... ..... |..     . ..|.||||||| .||..|. ..... ..         .. ..|.| |||.|| ..|. .
lllllrvgvasdqGrrksneDavlvvlnllslle.....dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeel

LRKAKR--ERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHmdcWRVNGTLAVSRAIGDVFQK------
|..| .  |.. |||| |.||| | .|.||..|||...|. .|..| | . |.| ...|..||...||.|||   .||||.|||.||.||...|      
lelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllsll

---PYVSGEADAASRALT-GSEDYLLLACDGFFDVVPHQEVVGLVQSHLTrQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDP
   |.|| | |  .. || .. |.||||.||..||....|.| .|.|.|. .. .   .||||| .| .|||.|||||.||.|...
lleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
PP2Cc_SM00332 151-411 7.4e-70 228.4 In-house 6-274 (274) alignment 
Range on Protein: 151-411
Range on HMM: 6-274/274.0
SQRQWLVSIHAIRNTRRKMEDRHVSLPSFNqlfglsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD-----PEGALREAFRRTDQMFLRK
|. ..  . ..  . |..|||.||. ....         . ..|.||||||| ..|.... ... . .....  .|     .| ||..||..||. .| .
snlglsygkssmqgwrksmeDahvvvvdlv......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeilee

AKRERL---QSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDVFQK-------P
.....|    ||.| |.||... .|.||..|||...|...|..| | . |.||..||..||.. ||.|.     ||||.||||||.||.| |       |
eqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkep

YVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQ-QGSGLRVAEELVAAARER-GSHDNITVMVV
|.. | |    .|| ... |.||.|| .||. .||||..|...|... . .. ..||.|...|..| ||.|||||.||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 149-413 4e-58 190.0 In-house 6-280 (282) alignment 
Range on Protein: 149-413
Range on HMM: 6-280/282.0
RASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLfglsdpVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL---------PTDPEGALREAFRRTD
.|....  ... . .. |..|||.|.   |...|       . ..|||||||.| ..|.|.. |...|  .. ||           . . |||..| ..|
qaegnglrygvssmqgwrvemEDahtvvaslgal......kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLald

QMFLRKAKRER--LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVShmdCWRVNGTLAVSRAIGDVFQKP--
.   .. .. .  ..||.| |..|.  ..| .| ||||  .|...|... | | |.|.|..|| |||. ||.|      ||||.||||||.|| . |   
eairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeee

-------YVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqGSGLRVAEELVAAARERGSHDNITVMVVFL
        ||.|.. .|   . ..|.|.||||| .||.  .||| ||...|...     .||..||  | |.||.||..|.||..
ekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlf
0049733 PP2C-like 162-414 3.7e-54 176.4 In-house 11-234 (235) alignment 
Range on Protein: 162-414
Range on HMM: 11-234/235.0
IRNTRRKMEDRHVSlpsfnqlfglsdpvNRAYFAVFDGHGGVDAARYAAVHVHTNAAR--QPELPTDPEGALREAFRRTDQMFLRKAKR--ERLQSGTTG
| . |. .||...               ....|||.|||||  |...|. ..... ..  .. |..|.| |||.||.......|..|..  |.  .||| 
igrvrkvneDavlv..............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTa

VCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVshmdcwRVNGTLAVSRAIGDVFQKpyvsgeADAASRALTGSEdYLLL
|.||. | .|.||..||| ..|...|..| | |.|.| ...|..||...||.|      ||.| ||..||.|| . |      .|  .  |.  . .|||
vvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlelepgd.flll

ACDGFFDVVPHQEVVGLVQShltrqqGSGLRVAEELVAAARERGSHDNITVMVVFLR
|.||..||....|.|.|..|       .   .||.|| .|..||..|||||.||.|.
asDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G2_pd Subfamily PPM1G2 152-413 2.7e-49 160.6 In-house 16-286 (287) alignment 
Range on Protein: 152-413
Range on HMM: 16-286/287.0
QRQWLVSIHAIRNTRRKMEDRHVSLPSfnqLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD-PEGALREAFRRTDQMFLRKAKRER
...  |.  |..  |..||| |.  .    |. .||  . |.||||||||| ..|.||. ...   |.....  .  | .|..|| .||. .|.. | . 
naltkvgssamqGyrlnmeDahilene...lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkd

LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDV-FQKPY--------VSGEA
 ..|.| | .||    | ||  |||. .| ..|.| .|   |.|....|| ||.| ||||.     ||||.||.|||.||  |.|          |  . 
esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpeeqivtavP

DAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSH------DNITVMVVFL
|   . |. ....|.||||| .||.  .||| ||...|.... .  ...|||.  .  . |.      ||.||..| |
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsga.kldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 156-413 8.7e-49 159.1 In-house 7-253 (255) alignment 
Range on Protein: 156-413
Range on HMM: 7-253/255.0
LVSIHAIRNTRRKMEDRHVSLPSFNqlfglsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL-PTDPEGALREAFRRTDQMFlrkAKRErLQSG
 |.   .   |  |||. |   ||.      |  .  |.|.|||||| .||..|. ...   |   .| ...|. .|..|.. .. ..   ..|     |
kvgfsdmiGrrptmedelviyGsfr......dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi...serp.kfiG

TTGVCALIAGATLHVAWLGDSQVILV-QQGQVVKLMEPHRPERQDEKARIEALGGFVSHM-DCWRVNGTLAVSRAIGDVFQKPYVSGEADAA-SRALTGS
|| . .|| .    .| .|||.|.|  ..|  ..|   |.|  ..|. ||..|||.|       |||||||||||.||.| .|.|  . |   |   . .
ttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk

EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgsglRVAEELVAAARERGSHDNITVMVVFL
. .|.||||| .|..  .| | .| .    .     . ||.|   | ..|| |||.|.|. |
dkflilacdGiwdlisdeeaveivagisdpe.....kaaeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 156-414 6.8e-41 133.3 In-house 6-267 (269) alignment 
Range on Protein: 156-414
Range on HMM: 6-267/269.0
LVSIHAIRNTRRKMEDRhvslpsFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHV------HT---NAARQPELPTDPEGALREAFRRTDQMFLRKA
 |......  | .||||      |.   .... ..  .|||||||||  || .|   .      .    .|... ..| . .  | .     |. .| ||
qvavysvlGrrprmedr......feieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklleka

KRERLQSGTTGVCALIAGATLHVAWLGDSQVILV-QQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVF--QKPYVSGEADA
||.   .||| . ||...  | || .|||. .|. ..|. . |   |.|..  |. ||.  |||..   .|||.| ||.|||.||    .|  |  . | 
kraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdi

ASRALTGS-EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSglrvAEELVAAARERGSHDNITVMVVFLR
 .  |     ..|.||.||..|    .| |  .. .|   .      |  ||  .  ||| |||||.|| |.
ltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfG....akslvlesfkrGsvdnitvlvvklk
PPM_PTC7_SpoIIE 158-404 7.9e-41 133.3 In-house 4-220 (230) alignment 
Range on Protein: 158-404
Range on HMM: 4-220/230.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDaaRYAAVHVHTNAARQPELPTD-PEGALREAFRRT--DQMFLrkakreRLQSG
. .|... |..|||.|.|.. ...    |.   .......|||||     .|. ...|  ...    .. || .||.....   |            .||
gasaaqgarksmedahispanseks...sggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede......psssg

TTGVCALIAGAT--LHVAWLGDSQVILVQQ-GQvvklmephrperqdEKARIeALGGFVS-HMDCWRVNGTLAVSRAIGDVFQKP---YVSGEADaASRA
.| |.||| . |  |.||..||| ..||.. |.              |. || ..||..|  .. .||.|.||||.|.||.. ..   .|. |.|  |. 
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdg

LTGS-EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgsglrvaeelvaaARERGSHD
.. . ...| ||.||..||.. ||.| ||...| .               | |.. .|
elfgkdeflilasdglwdvlspqelvdlvrdelekp..............aaeglleD
subfamily_ILKAP_pd Subfamily ILKAP 158-412 4e-39 127.5 In-house 7-291 (293) alignment 
Range on Protein: 158-412
Range on HMM: 7-291/293.0
SIHAIRN-TRRKMEDRHVSLPSFNQLFGLSD-PVNR-AYFAVFDGHGGVDAARYAAVHVHTNAARQ-P--ELPT---DPEGALREAFRRTDQMFLRKAKR
...| |.  | .|.| || | ....  .|.. .|.| .|.||||||.|  |...|| ..| .  .. |  .. .   .   .| ..|..||. ||..|..
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask

ER--LQSGTTGVCALIAGATLHVAWLGDSQVILVQQ---GQ---VVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDV-FQKPYVSG
..   . |.| .. |.   .|.|| ||||. .||..   |.   .|.|   | | ...|. ||.  ||.| .    ||.| | |||.|||  |..  |. 
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGvis

EADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQ------QGSG--------LR-VAEELVAAARERGSHDNITVMVVF
  |     ||  . ...|||||...|.  .|||  ... |  .      ...         .. ... | . | .||| ||.||..| 
tPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
subfamily_PPM1K_pd Subfamily PPM1K 191-414 1.5e-36 118.9 In-house 31-259 (263) alignment 
Range on Protein: 191-414
Range on HMM: 31-259/263.0
RAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAK-----RERLQSGTTGVCALI-AGATLHVAWLGDSQVILVQQGQ
  |.||||||.|. || ..  ....   |  |   | |  |..||   |. . | ..     .| |.||||   .|.  |  | .| ||||. || ..|.
llyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk

VVKLMEPHRPERQDEKARIEALGGFVSH--MDCWRVNGTLAVSRAIGDVFQKPY-VSGEADAASRAL-TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLT
  || . | ||...|| || | ||.|.   ..  .||| ||..|..||.  |.| |  . .. |  .  ... .|.|  ||  .||  ||.  ||.    
akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchd

RQQgsglrVAEELVAAARERGSHDNITVMVVFLR
 ..      |. |. .| . ||.|| |..|| |.
pee.....aahalteqalqygsednatavvvplg
subfamily_PPM1D_pd Subfamily PPM1D 158-414 4.3e-31 101.1 In-house 5-308 (309) alignment 
Range on Protein: 158-414
Range on HMM: 5-308/309.0
SIHAIRNTRRKMEDRHVSLPSFNQLFGlsdPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPE----GALREAFRRTDQMFLR-------KA
. .| .  |. |||. .   . ..      ... |..|||||||| .||..|  |. ..  .| .. ....     |.||||  | .   .       ..
tseadqGgrkymeDvvaivleeeesae...elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktk

KRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQ------VVKLMEPHRPERQDEKARIEALGGFVSHM-----DCWRV-----NGT--------L
. .   .|||  . .| .  |.||  |||...| .. .        .|.. |.||  .|| ||| ||| |...      .|.      ||         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

AVSRAIGDVF-----QKPY-VSGEADAASRALTGSED-YLLLACDGFFDVVPHQEVVGLVQSHLTRQQG---SGLRVAEELVAAARERGSH-----DNIT
||.|..||..     .. . || | |   | |...|. ...|| ||...|.. ...| .|... . ..    ..  ||. ||  | .| ..     ||..
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvs

VMVVFLR
|.||.|.
vivvile
subfamily_PPM1G_pd Subfamily PPM1G 251-414 1.5e-28 93.0 In-house 294-471 (473) alignment 
Range on Protein: 251-414
Range on HMM: 294-471/473.0
LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVShMDCwRVNGTLAVSRAIGDVFQKP---------YVSGEA
 .|||| | ||. . .| ||  |||  .| ..|. . | . |.|| . |..|||. || |  .|  |||| | .|||.|| . |           .|   
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvd.edg.RvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGS-GLRVAEELVAAA-----RERGS-HDNITVMVVFLR
|   ..||  ...| ||||| ..|.  ||||  |...|. .. |   .. |||. |.        |.  || ||..| |.
DikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllk
subfamily_KAPP-like_pd Subfamily KAPP-like 167-412 1.9e-20 66.0 In-house 10-265 (266) alignment 
Range on Protein: 167-412
Range on HMM: 10-265/266.0
RKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL-----PTDPEGALREAFRRTDQMFLRKAKRERLqSGTTGVCAL
 .||| ...   . .   ||.  | | ||||||| |  ||  |   .  .  .. .        |.    .. .. . .    | |      |.|   ||
temedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfey.eGatatlal

IAG----ATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCwRVNGtLAVSRAIGDVFQKPYV---SGEADAASR-ALTGSED
.        | || .|||  .| .  . ..|   |. . ..|| ||   |  .|. .  |.|| ||||||.|| | |      ..|   ..| .||  ..
vwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdk

YLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGlRVAEEL-VAAARERGSHDNITVMVVF
.|..| ||..||.  .. .  |.|   .|. .  ..|. |  .| .   ..||..|.|| 
flivasdGlwdvisGkdaiekvkslydqqated.kmasslletaiqsikakdnvsvivvk
PP2C_SIG_SM00331 185-412 1.9e-19 63.1 In-house 24-216 (217) alignment 
Range on Protein: 185-412
Range on HMM: 24-216/217.0
LSDPVNRAYFAVFDGHG-GVDAARYAAVHVHTNAARQPELptdpeGALREAFRRTDQMFLRKakRERLQSGTTGVCALI--AGATLHVAWLGDSQVILVQ
....  |  ..|.||.| |..|| ...  ..       |       .| .|..|... . ..   |  ....| ..||.  ....|..| .||| ..|..
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr

QGQVVKLMEPhrperqdekariealggfvsH-----------MdcwrvngtlavsraigdvfqkpyvsgeadAASRALTGS-EDYLLLACDGFFDVVPH-
.|. |.  .                                 .                             . .| |. . .| |||. || .... . 
dgklveilkd....................vegaplGlepevs.............................vdirelelekgdllllytDGltearsek

----QEVVGLVQSHLTRQQGSGLR-VAEELVAAARERGSHDNITVMVVF
    ... ........       .   |||...|.... .|.|||.||.
gfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
PPM_PTC7_motif 356-406 8.9e-18 57.5 In-house 1-51 (51) alignment 
Range on Protein: 356-406
Range on HMM: 1-51/51.0
LLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNI
.||.||..||...||.|.||...|. . .|. ..||.||  |..|||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 194-331 3.8e-17 55.8 In-house 24-183 (292) alignment 
Range on Protein: 194-331
Range on HMM: 24-183/292.0
FAVFDGHG--GVDAARYAAVHVHTNAA-RQPELPTDPEGALREAFrRTDQMFLRKAKRERLQSGTTGVCALIAGA-TLHVAWLGDSQVILVQ-----QGQ
 ||.||||  |   | .|. ..  .     ..|   .|  |      .   . .    .|....|. ||| .     | .| .|||...| .     . .
aavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye

VVKLMEPHRPERQDEKARIEALGGFVS--HM------DCWRV------NGTLAVSRAIGDV
.. |   |.||  ||.||| . ||.|   ..         ||      .| ||.|||.||.
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
subfamily_PP2D1_pd Subfamily PP2D1 260-383 2.2e-15 49.3 In-house 183-310 (492) alignment 
Range on Protein: 260-383
Range on HMM: 183-310/492.0
ALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFV-SHMDCWRVNGTLAVSRAI---GDVFQKPYVSGEADAASRALTGSEDYL
 |.  ..|..|  |. | .|...|. ..|   | |. . |. |.|  |. | .   . .||| | . | .   ||   |  |  |    |  |.    .|
hleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqfl

LLACDGFFDVVPHQEVVGLVQSHLTRQQ
.||  | ..|. ..||. ||.. |.  .
vlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 267-412 2.3e-15 49.2 In-house 128-275 (276) alignment 
Range on Protein: 267-412
Range on HMM: 128-275/276.0
LHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCwRVNGtLAVSRAIGDVFQKPYV---SGEADAASR-ALTGSEDYLLLACDGF
| || .|||  .| .  . ..|   |. .  .|| ||   |  .|. .  |.|| ||||||.|| | |      ..|   ..| .||  ...|..| ||.
lqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGl

FDVVPHQEVVGLVQSHLTRQQGSGlRVAEEL-VAAARERGSHDNITVMVVF
.||.  .. .  |.|   .|. .  ..|. |  .| .   ..||..|.|| 
wdvisGkdaiekvkslydqqated.kmasslletaiqsikakdnvsvivvk
Subfamily Dicty-PPM1L-like 296-414 7.3e-14 44.3 In-house 179-304 (305) alignment 
Range on Protein: 296-414
Range on HMM: 179-304/305.0
RQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSED-YLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSG------LR
..... ||| |.. . ..   .||. | .|| .||   | .|  . |     .. ..| .|.|| ||  .|. .|.||. |.  |  .. ..        
ldeiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne

VAEELVAAARERGSHDNITVMVVFLR
. .  |  | .||| ||||.....|.
isrviveeavkrgsgDnitlviiklk
subfamily_PHLPP_pd Subfamily PHLPP 266-413 1.1e-11 37.1 In-house 106-245 (246) alignment 
Range on Protein: 266-413
Range on HMM: 106-245/246.0
TLHVAWLGDSQVILVQQGQVVKLMEPHRPERQdEKARIEALGGFVSHMDcwRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACDGFFDV
.|.||  |  | .|. .|. ..| ...  |.. |  ||    ....  .  ..|| .. .| .| .|  |.|  .    .  ||  ...|..  . ...|
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWev

VPHQEVVGLVqshltRQQGSGLRVAEELVAAARERGSHDNITVMVVFL
.  .|.|  |     |.. . | .|  ||  |   | .|...|.|| |
lsideaveav.....rkeedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_TAB1_pd Subfamily TAB1 249-334 1.3e-10 33.7 In-house 125-213 (333) alignment 
Range on Protein: 249-334
Range on HMM: 125-213/333.0
ERLQSGTTGVCALIAGATLHVAWLGDSQVILVQ---QGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQK
| .. ||| | |||    |.||  |||. .||.   . .|..|   |  . .||  |.. ||  . ..   .. |     |.|||   |
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvk
subfamily_PPM1H_pd Subfamily PPM1H 229-306 8.1e-10 31.0 In-house 138-213 (404) alignment 
Range on Protein: 229-306
Range on HMM: 138-213/404.0
GALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERqdEKARIEAL
||| .|| . |..  |  .. |.. | | . ||.    |.||  |||. |||.......| . . ||   |. |.  |
GalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlqel
subfamily_PDP_pd Subfamily PDP 333-384 1.2e-08 27.5 In-house 266-317 (398) alignment 
Range on Protein: 333-384
Range on HMM: 266-317/398.0
QKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQG
  ||.. | .  |. |. .. .|.|| || .|.. ..||| ||. ||.... 
tPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkke
PPM_PTC7_SpoIIE_motif 352-411 2.2e-08 27.7 In-house 12-78 (81) alignment 
Range on Protein: 352-411
Range on HMM: 12-78/81.0
EDYLLLACDGFF-------DVVPHQEVVGLVQSHltrQQGSGLRVAEELVAAARERG---SHDNITVMVV
 | |||..|| .       .... .|.. |....   ...|  ..|..||....|.|   ..|.||..|.
gdvllLyTDGltEardsdgelfgkeellrladra...egkslqeladklvdevlengsgereDDitllvl
PP2C_2 Protein phosphatase 2C 188-302 8.8e-08 24.7 Pfam-A 21-147 (212) alignment 
Range on Protein: 188-302
Range on HMM: 21-147/212.0
PVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPE-LPTDPEGA-LREAFRRTDQMFL--------RKA-KRERLQSGTTGVCALIAGATLHVAWLGDSQ
  .. ..|| ||.|    .. .|  . ..|... | | .. . .  ....|.. .  |        ..| . |  . .|| ..|.|.. .. ....||. 
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

VILV-QQGQVVKLMEPHRPERQDEKAR
.... ..|.|  | ||.  | . |  .
ivvrdrdgevqllgepdsgeyanettf
PP2C_2 Protein phosphatase 2C 188-302 8.8e-08 24.7 In-house 21-147 (212) alignment 
Range on Protein: 188-302
Range on HMM: 21-147/212.0
PVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPE-LPTDPEGA-LREAFRRTDQMFL--------RKA-KRERLQSGTTGVCALIAGATLHVAWLGDSQ
  .. ..|| ||.|    .. .|  . ..|... | | .. . .  ....|.. .  |        ..| . |  . .|| ..|.|.. .. ....||. 
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

VILV-QQGQVVKLMEPHRPERQDEKAR
.... ..|.|  | ||.  | . |  .
ivvrdrdgevqllgepdsgeyanettf
subfamily_PPM1G_pd Subfamily PPM1G 154-245 3.6e-07 22.6 In-house 18-102 (473) alignment 
Range on Protein: 154-245
Range on HMM: 18-102/473.0
QWLVSIHAIRNTRRKMEDRHVSLPSFNQlfglsdpvNRAYFAVFDGHGGVDAARYAAVHVHTN-AARQPELPTDPEGALREAFRRTDQMFLRK
.  ... |    | ..|| | ... ...        . . |||.||||| . |.| | ..     |..     | | ||.|||   |.    .
elsygasamqGwrvsqEDahncitdlde........dtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkae
SIP1 Survival motor neuron (SMN) interacting protein 1 (SIP1) 84-161 1.5e-06 14.1 Pfam-A 107-179 (233) alignment 
Range on Protein: 84-161
Range on HMM: 107-179/233.0
VSQLLQTDLSEFRKLPREEEEEEEdddEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARasQRQWLVSIHA
||. ...| ....|  .||| ..|   ...  | .| . ..| ||  ..| |.. .|.|.  |     ...||... |
vsppktedeekwkkfcleeelase...dktgfpplLtivsklnqsdvsslleylvkwekeeglese..lgrWlyalla
subfamily_PDP_pd Subfamily PDP 233-331 2e-06 20.2 In-house 133-238 (398) alignment 
Range on Protein: 233-331
Range on HMM: 133-238/398.0
EAFRRTDQMFLRKaKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQ---G--QVVKLMEPHRPERQDEKARIEALGGFVSH---MDCWRVNGTLAV
||......  ||. . .   ||.. ..||| | .||||  ||.. .| .|   |  ..||| . .  . ..|  ||..      .   .   |. |.|. 
ealkklkekslre.allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqP

SRAIGDV
.|| |||
lRAFGdv
subfamily_PP2D1_pd Subfamily PP2D1 163-219 4.5e-06 18.6 In-house 9-61 (492) alignment 
Range on Protein: 163-219
Range on HMM: 9-61/492.0
RNTRRK--MEDRHVslpsFNQLFGlsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAAR
.|.| |  |||...    . . ||  . ||...|...||. |  ||. || ..|.  ..
knsrWKskmeDkrt....lqdyfg..ndvnscFfgiyDGynGataAeiaakelhevlle
CaMBD Calmodulin binding domain 147-170 9.8e-06 11.9 Pfam-A 36-59 (77) alignment 
Range on Protein: 147-170
Range on HMM: 36-59/77.0
AARASQRQWLVSIHAIRNTRRKME
..|  ||. | .||..|... .. 
rlrkhQRklLkaihkfRkvklelr