Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1G_pd | Subfamily PPM1G | 4-507 | 6.4e-210 | 691.1 | In-house | 1-472 (473) | alignment | ||
Range on Protein: 4-507
Range on HMM: 1-472/473.0
YLSQPNTVKCSGDGVgapRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDA
|||.|.. | | |. . | ||.|||||||||.|||||||..||..|..|.|||||||.||| |.||.|||..|.||.||||...||||.||||.|.
ylskpkvekesedes...neelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe
KLTTEEVIKELAQIAGrPTEDEDEKekvADEDDVDNEEAALLHEEATMTIEELLTRYgqnchkgpphskSGGGTGEEPGSQGLNGEAGPEDSTRETPSQE
||..||..|||..||. ..|||||. ...|. |..|..||.|||.....|||.|. .| |...| || |. .| ||...|....|
klkaeeslkelkeiae.aeededee...eeddeededeiellteeaeipldellkrl............dgdgsekeelsqallegaasedeedededee
NGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLprvakskffEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEE
. ...|.....|...|. ..|.. |.. . .... ........| |..|||..|.|||||..|...||||....||.|.||||.|.||.||
eeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeeke.........eeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeee
DDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDH
|.|.||......|.|.|||||.||||||||||...|.||||||||||||.|..|||||.|.||||||||||.||..|||||..|||||||||||||.|||
dgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDh
FYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgelrLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIII
.||.|..||..||||||||||||||||...||.|.|||||||||.|||||||...|.....|. ||.|||||||.|||||||||||||||||.||.
aYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtviiv
CFKP
..|.
llkk
|
|||||||||
PP2Cc_SM00332 | 22-503 | 1.4e-98 | 322.6 | In-house | 7-274 (274) | alignment | |||
Range on Protein: 22-503
Range on HMM: 7-274/274.0
RLPLPYGFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG----KLQKALEDAFLAIDAKLTTEEVIKELA
.| |.||.|.|||||.||||||.....|. .....|.|.|||||.||| ...|.||...|... .|.. . ..||..|||..| ....|| |||
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele
Qiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptakaytgfs
.
n...................................................................................................
snsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeeeemmvp
....................................................................................................
gmegkeepgSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGkVTMDGRVNGGLNLSRAIGDHFYKRNKnlPPEE
..||.||||||.....|.|||.||||.|....|||...|.|||||||.|..|||.||| |...|||||||..|||.||||.|.|| ...|
.........alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.vvekgrvngglavsrafGdhflkknk..klke
QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengeLRLLSSIVEELLDQCLAPDtsgdGTGCDNMTCIII
..|.|.||.||.|||...||...|.||.|.|.|.|||||......... . . ..||||...... |...||.|....
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairr....ggseDniTvvvv
|
|||||||||
0034914 | PP2C-like | 21-507 | 9.2e-76 | 247.3 | In-house | 17-292 (295) | alignment | ||
Range on Protein: 21-507
Range on HMM: 17-292/295.0
PRLPLPYGFSAMQGWRVSMEDAHNCIPEL---DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-------KAYKEGKLQKALEDAFLAIDAKLTTEEV
| | .|.. .||.| |.|||. ....| ......| |.||||| ..| .....|....... . . ...||..||||.| .| .. .
lllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelal
IKelaqiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptaka
.
lr..................................................................................................
ytgfssnsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeee
....................................................................................................
emmvpgmegkeEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMdGRVNGGLNLSRAIGDHFYKRNKN
. ||||||||||||..|.|||.||||.|.. |... ...|||| .| | .||..||| |.. |||||.|...||.||...|....
...........pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlkllls
LPPEEQMISALPDIKVLTLT-DDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFKP
|...|...|| ||..||.|| .|..|...|.||.|.|.|..|.||...| ...... |. ..|||.|..|| . ..||.|........
lllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsrDNiTvvvvrlng
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 324-505 | 7.6e-69 | 224.8 | In-house | 112-286 (287) | alignment | ||
Range on Protein: 324-505
Range on HMM: 112-286/287.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDgRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPD
...|.||||.||. ..|.||||||||.|.|..|.. .|.||||..| | ||..||| | .. |||| | ||||.||. .|.|....||||.. |.||
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtavPD
IKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF
. | |..|.||.|.||||||.|....||||......... . |..|.|||||.|||||.| | ||||||..|...
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 274-506 | 2.2e-59 | 194.1 | In-house | 85-281 (282) | alignment | ||
Range on Protein: 274-506
Range on HMM: 85-281/282.0
SEECSEEEDGYSSEEAENEEDEDDTEEAEEDdeeeeeemmvpgmegkeepgsdsGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVE
.| .. ..|. . . . .|...|...|.. |.|||..|.. |.||.||.|||| |... ||| ...||||... |
devkealrqgfLaldeairelstdlktadks.......................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkE
LARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELrlls
||..|||.|. .|||| | .|||.||..||.......|||..|| |..... .....|.|.|||||| |.|..|||......... || |.
kkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev....
siVEELLDQCLAPDTSgdgtgcDNMTCIIICFK
...|.|..| .. ||.......|.
..akalvdkalekgsr......DNlsvlvvlfa
|
|||||||||
PP2C | Protein phosphatase 2C | 320-489 | 3.1e-59 | 193.6 | Pfam-A | 94-252 (255) | alignment | ||
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
.. |.||.||||||||||.|.|||.||||.|.. ...| ...||||.|| | .||..|||.| ||||| |..|||.||...|... ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv
SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. . .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
|
|||||||||
PP2C | Protein phosphatase 2C | 320-489 | 3.1e-59 | 193.6 | In-house | 94-252 (255) | alignment | ||
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
.. |.||.||||||||||.|.|||.||||.|.. ...| ...||||.|| | .||..|||.| ||||| |..|||.||...|... ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv
SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. . .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
|
|||||||||
PPM_PTC7 | 323-489 | 2.8e-58 | 190.4 | In-house | 97-256 (259) | alignment | |||
Range on Protein: 323-489
Range on HMM: 97-256/259.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVT--MDGRVNGGLNLSRAIGDHFYKRNKNlppEEQMIS
|.||.|||||||.|..|.|||.||||.|.. |.| ...||||..| | .||..|||.| .||||| |..|||.||...|... |||..|
epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvs
ALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengelrLLSSIVEELLDQCLAPDTS
| |||.. ......||...|.||.|.|.|.||.||...| .|.. .. . |.|.| ..|....
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargse
|
|||||||||
0049733 | PP2C-like | 323-506 | 5e-39 | 127.0 | In-house | 88-234 (235) | alignment | ||
Range on Protein: 323-506
Range on HMM: 88-234/235.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVtmdgRVNGGLNLSRAIGDHFYKrnknlppeeqmisalP
. . .||||||||..|..|.|||.||||... ||.. ...||.| .| | .||..||| | ||.|.| |.||.||...| |
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............p
DIKVLTLTDDHeFMVIACDGIWNVMSSQEVVDFIQSkisqrdengelRLLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFK
|. ||.|.... |...|.||.|.|.|..|.||...| |. ..|.|....|| . |.||.|.......
dvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrld
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 288-478 | 2.4e-37 | 121.5 | In-house | 66-245 (265) | alignment | ||
Range on Protein: 288-478
Range on HMM: 66-245/265.0
EAENEEDEDDTEEAEEDDEEEEEEMMVPGmegKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD
....|....|..|| .. .. .|... |. . ||.||||.||...|| || |||. .. . |.|. . ||||.| | .||..||| | .
lvrqeklkedpaealkeafkltDerflqk...aereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi
G--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgELRLLSSIVEE
| |||| |..|||||| .| ...|. .|. ..|....|....||||.|.|. .|||. ... ... |. . .. ..||.
gawRvnGvLsvsRaiGDvklk.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaed.lsevakllvea
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 326-462 | 4.4e-32 | 104.4 | In-house | 105-238 (269) | alignment | ||
Range on Protein: 326-462
Range on HMM: 105-238/269.0
DSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrNKNlppeeqMISALP
.||||..||.....||||| |||| |. . |||. .|.||||.. | |||.||| ....| ||.| | |||.||. | .|| .. | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.dkn......lviadp
DIKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQ
|| . | | ||...|.||.|. .| .| | ||. ....
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 325-464 | 1.3e-31 | 102.8 | In-house | 93-227 (255) | alignment | ||
Range on Protein: 325-464
Range on HMM: 93-227/255.0
SDSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMD---GRVNGGLNLSRAIGDHFYKrnknlpPeeqMISA
||||...|| ... ..|| |||| |.. | | .|.|||| .| | ||...||.| . |||| | .|||.|| | . | . .
kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle......P...fvvp
LPDIK-VLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSkISQRD
||.. |. . ...|...||||||...| .| |. . . ||. .
dPdlsqsleiskkdkflilacdGiwdlisdeeaveivag.isdpe
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 320-467 | 2.2e-30 | 98.8 | In-house | 106-250 (293) | alignment | ||
Range on Protein: 320-467
Range on HMM: 106-250/293.0
KEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVV---SEAGK---ALDMSYDHKPEDEVELARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKnlpp
|..| |.||.| |. . | ||| |||..|. .|.|. .. .. ||.| .. | ||. |||.|. ||||.| |. ||.||| .||
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlG....
eeqmISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
... ||.| ..||.. |.|.||||.|.|.| .|||.||.. . .....
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr
|
|||||||||
PPM_PTC7_SpoIIE | 320-463 | 2.6e-28 | 92.4 | In-house | 87-212 (230) | alignment | |||
Range on Protein: 320-463
Range on HMM: 87-212/230.0
KeepGSDSGTTAVVALIRGKQ--LIVANAGDSRCVVSEA-GKaldmsydhkpedevELARIkNAGGKVT---MDGRVNGGLNLSRAIGDHFYKRnknlpp
. |.||.|||||||.. . | |||||||..... . |. | || ||| . ..|||.| |..|.|.|| ...
e...psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......
EEQMISALPDiKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQR
......| || . ..... .||...|.||.|.|.|.||.||.... ...
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 325-458 | 1.2e-26 | 86.4 | In-house | 96-227 (263) | alignment | ||
Range on Protein: 325-458
Range on HMM: 96-227/263.0
SDSGTTAVVALIR-GKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD----GRVNGGLNLSRAIGDHFYKRNKnlppeeqmIS
||||| |.|.| |..|..|. |||| .. ||| .. ||.|| | | |||.|||.|... .||| | ..|..|| || .
lssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........vi
ALPDIKVLTL-TDDHEFMVIACDGIWNVMSSQEVVDFIQS
| |. | | . .. |.|. ||| .|..|||. |...
atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 27-113 | 1.4e-26 | 86.1 | In-house | 21-112 (287) | alignment | ||
Range on Protein: 27-113
Range on HMM: 21-112/287.0
YGFSAMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKE
| |||||.|..||||| .|| |...|.|.|.|||||..|| |..| | .|. .|..|||.|...|.||||..| .|. .| .|.
vgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkd
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 327-467 | 1.1e-23 | 76.6 | In-house | 100-239 (266) | alignment | ||
Range on Protein: 327-467
Range on HMM: 100-239/266.0
SGTTAVVALIR--GKQ--LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAl
|.|| .||. |.| | ||| ||| .| ..| .|.||| .|. | |||. | .. . |.| || .|||.|||| |. |. .||
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.
PDI-KVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
| . . ..|| ..|...| ||.|.|.| .. .. ..| |.. .
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqated
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 324-469 | 4.5e-23 | 75.0 | In-house | 149-321 (398) | alignment | ||
Range on Protein: 324-469
Range on HMM: 149-321/398.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVS---EAG--KALDMSYDHKPEDEVELARIKNAGG-----KVTMDGRVNGGLNLSRAIGDHFYKRNKNLPP
. ||..|..|||.|..| |||.||.|.|. | | .| .| |. . | |. |||.. | ..||. | | .|| || || ...|
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqk
-------------EE----QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGEL
.. ..| |.. |. . |.|.| ||.|...|..|||. .. .....|. ..
kvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 339-467 | 1.1e-21 | 69.9 | In-house | 126-249 (276) | alignment | ||
Range on Protein: 339-467
Range on HMM: 126-249/276.0
KQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAlPDI-KVLTLTDDHEFM
. | ||| ||| .| ..| .|.||| .| | |||. | .. . |.| || .|||.|||| |. |. .|| | . . ..|| ..|.
rylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.pyvsnrilltpfdkfl
VIACDGIWNVMSSQEVVDFIQSKISQRDENG
..| ||.|.|.| .. .. ..| |.. .
ivasdGlwdvisGkdaiekvkslydqqated
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 23-111 | 1.7e-20 | 66.6 | In-house | 10-108 (282) | alignment | ||
Range on Protein: 23-111
Range on HMM: 10-108/282.0
LPLPYGFSAMQGWRVSMEDAHNCIPELDSE--TAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAY--------KEGKLQKALEDAFLAIDAKLTTEEVI
..| || |.||||||.|||||... .| . ..|.|.|||.|.||| |..| |.. | ..... .. ....||...|||.| .. ...
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 326-463 | 5.8e-18 | 57.8 | In-house | 175-309 (492) | alignment | ||
Range on Protein: 326-463
Range on HMM: 175-309/492.0
DSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKV---TMDGRVNGGLNLSRAIGDHfykRNKNLppeEQMISALP
.. . | |. | .||||. . |. .||| . .| |... | |...||. | |.||| |. | .| . . .| .. . |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP
DIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQR
.. .|.. |.|.| |.|.|.| .||. ... . .
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy
|
|||||||||
PPM_PTC7 | 27-107 | 2.9e-17 | 56.0 | In-house | 3-91 (259) | alignment | |||
Range on Protein: 27-107
Range on HMM: 3-91/259.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA--IDAKLTT
.|.||.||.|.|||||| . . . ... | |.|.||||| |.| |... |..|.| .| .|. ||.||| ..||| .| .|..
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks
|
|||||||||
PP2C | Protein phosphatase 2C | 27-107 | 3.2e-17 | 55.9 | Pfam-A | 3-90 (255) | alignment | ||
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ... . .|. |.| |.|||||.|.| |... |..|.| || .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
|
|||||||||
PP2C | Protein phosphatase 2C | 27-107 | 3.2e-17 | 55.9 | In-house | 3-90 (255) | alignment | ||
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ... . .|. |.| |.|||||.|.| |... |..|.| || .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 327-449 | 1.7e-15 | 49.6 | In-house | 129-262 (333) | alignment | ||
Range on Protein: 327-449
Range on HMM: 129-262/333.0
SGTTAVVALIRGKQLIVANAGDSRCVVSE---AGKALDMSYDHKPEDEVELARIKNAGG---KVTMDGRVnGGLNLSRAIGDHF----YKRNKNLP-PEE
||||||||| ..| |||.|||| .. . | .| ||. . | || |.|. | .. .|. |. . |.|||. || .. | ..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg
QMISALPDIKVL-TLTDDHEFMVIACDGIWNVMSS
. . | |||. ..| |.|. ||. . .
ePviaePdiqgaypiddityflvlmSdGvyktLee
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 325-404 | 3.1e-15 | 49.5 | In-house | 83-184 (292) | alignment | ||
Range on Protein: 325-404
Range on HMM: 83-184/292.0
SDSGTTAVVALIRGK-QLIVANAGDSRCVVSE-----AGKALDMSYDHKPEDEVELARIKNAGGKVT----------MDGRV------NGGLNLSRAIGD
..|..| | .| .||.|| ||||... . .| |||||| | |||..|||.|. || .|.| ||||.||
esattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
HF
fh
|
|||||||||
PPM_PTC7_motif | 437-489 | 1.1e-13 | 44.4 | In-house | 1-48 (51) | alignment | |||
Range on Protein: 437-489
Range on HMM: 1-48/51.0
VIACDGIWNVMSSQEVVDFIQSKIS-QRDengelrLLSSIVEELLDQCLAPDTS
..|.||.|.|.|.||.||.... .| ... . .. |.| |..||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl......spqeaAeklvdealargse
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 340-458 | 1.8e-13 | 43.0 | In-house | 106-214 (246) | alignment | ||
Range on Protein: 340-458
Range on HMM: 106-214/246.0
QLIVANAGDSRCVVSEAGKALDMSYDHKPEDEvELARIKNAGGKVTMDGRVNGGLNLSRAIGdHFYKRNKNLPPeeqmisalPDIKVLTLTDDHEFMVIA
.| ||. | |. || | .| .. |.. || |||.| . .| |...|| .. .| .| ... || | .. ..||.. |....
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdellivG
CDGIWNVMSSQEVVDFIQS
. .|.|.| .|.|. ..
nkalWevlsideaveavrk
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 394-506 | 1.8e-13 | 43.2 | In-house | 201-308 (309) | alignment | ||
Range on Protein: 394-506
Range on HMM: 201-308/309.0
LNLSRAIGDHFyKRnkNLPPEEQMISALPDIKVLTLTDDHE-FMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRllSSIVEELLDQCLApDTSGDG
|...|..|| . | .| ..| ||.|| ||. ..| |...| ||.|||......|...... ... ..| .|... |... | ..
LavaRslGDlW.sy..naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealq.rwrskk
TGCDNMTCIIICFK
.||.. |.....
lraDnvsvivvile
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 324-387 | 1.1e-12 | 40.7 | In-house | 105-174 (309) | alignment | ||
Range on Protein: 324-387
Range on HMM: 105-174/309.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGK------ALDMSYDHKPEDEVELARIKNAGGKVTMD
| .|||| | .||...| ||. |||. |.. . | . |||||. | ||...||.|..
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
|
|||||||||
0049733 | PP2C-like | 25-108 | 2.5e-12 | 39.9 | In-house | 3-82 (235) | alignment | ||
Range on Protein: 25-108
Range on HMM: 3-82/235.0
LPYGFSAMQGW-RVSMEDAHNCipeldsETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-KAYKEGKLQKALEDAFLAIDAKLTTE
| .|.. ..|. | .|||. . ....| |.||||| ... .....|....... ... . .|..||..||||... | .
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 30-108 | 5.4e-12 | 38.4 | In-house | 9-94 (265) | alignment | ||
Range on Protein: 30-108
Range on HMM: 9-94/265.0
SAMQGWRVSMEDAHNCIPEL----D----SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLqKALEDAFLAIDAKLTTE
|... | ||| | ....| . .|.|.|.|.||||| | | | |. |. . .|. || . .||..|| ..| ....
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 28-107 | 1e-11 | 37.4 | In-house | 7-84 (263) | alignment | ||
Range on Protein: 28-107
Range on HMM: 7-84/263.0
GFSAMQGWRVSMEDAhNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKaYKEGKLQKALEDAFLAIDAKLTT
|. ...| | || .. ||| | ..|.|||.| | .. . | |.|. . || .|.. | .||. .| ||.
GkdsliGkraenedr.iklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr
|
|||||||||
PPM_PTC7_SpoIIE | 27-108 | 2.6e-11 | 36.8 | In-house | 3-87 (230) | alignment | |||
Range on Protein: 27-108
Range on HMM: 3-87/230.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEvaLYCAKYLPDIIKDQKaYKEGK-LQKALEDAFLAIDAKLTTE
.|.||.||.| |||||| . . .. ... ..||||| . .... | .... .. .... . ..|....||..|.|..|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 244-372 | 9.1e-11 | 34.1 | In-house | 80-207 (404) | alignment | ||
Range on Protein: 244-372
Range on HMM: 80-207/404.0
ASDKLPRVAKSKFFEDSEdESDEAEEEEEDSEECSEEEDGYSSEEAENEED---EDDTEEAEEDDEEEEEEMMVpgmEGKEEPGSDSGTTAVVALIRGKQ
|| .| .. |.|. . | | ..|||. |.|..|. .| .| .|.. |. | |. | .|.. . .|. | ||.|||. ..
askllhkhlkekledvle.llleksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqia...rereayrikGGCtalvalvllgk
LIVANAGDSRCVVSEAGKALDMSYDHKPEDEV
| |||||||| .... .. ..| |. || |
lYvanaGDsRailvrkdeiiplsadftPeteR
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 31-106 | 1.1e-10 | 34.1 | In-house | 8-91 (309) | alignment | ||
Range on Protein: 31-106
Range on HMM: 8-91/309.0
AMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYK---EGKLQKALEDAFLAIDAKLT
| || | ||| | . | |...|.|||||.| | . . | ||.|| . . ....|...||||. ..
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamk
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 28-107 | 2.1e-09 | 30.0 | In-house | 9-90 (255) | alignment | ||
Range on Protein: 28-107
Range on HMM: 9-90/255.0
GFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTT
||| | | | .||| . |. .....|||||.. | .... |. |... .. . .|.|..|. .|. ...
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqise
|
|||||||||
PP2C_SIG_SM00331 | 323-503 | 2.1e-09 | 30.3 | In-house | 82-215 (217) | alignment | |||
Range on Protein: 323-503
Range on HMM: 82-215/217.0
PGSDSGTTAVVALI--RGKQLIVANAGDSRCVVSEAGKAL-DMSYdhkpedevelariknaggkvtmdgrvngglNLSRAIG-----Dhfykrnknlppe
.....|...||. ....| .|||||||... || . . ......| .
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs............
eqmisalPDIKVLTLTDdHEFMVIACDGIWNVMSSQE-----VVDFIQSKIsqrdeNGELRLLSS-IVEELLDQCLAPDTsgdgtgCDNMTCIII
.||. |.| ...... ||.....|... . ...... . |.. |.. |||||| . .. . |..| ...
.......vdirelelek.gdllllytDGltearsekgfaeerleeiledlv.....dseaqelaqkiveellelakgsng......eDdiTvvvv
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 31-119 | 4.6e-09 | 28.9 | In-house | 11-107 (269) | alignment | ||
Range on Protein: 31-119
Range on HMM: 11-107/269.0
AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPDIIKDQK----AYKEGKL----QKALEDAFLAIDAKLTTEevIKELAQIAG
...| | ||| . ... .| .|.|.|||||| | .. . |.. ||.. | || .. .| |.| |..| || .. .| .|||
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek..akraediaG
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 389-506 | 2.4e-08 | 26.2 | In-house | 200-304 (305) | alignment | ||
Range on Protein: 389-506
Range on HMM: 200-304/305.0
RVNGGLNLSRAIGDHFYKRNKNlPPEEQMIsalpdiKVLTLTDDhEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDT
.||. |. || .|| | |.... . .|.. ..| .|.|.| ||.|.|.| |.||.... .. .. .. . . .. .
lvnrllkksrskGdknlkelvi.Pnndspl......lvvakanD.qflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrg
SGDgtgcdNMTCIIICFK
||| |.| .|| .|
sgD.....nitlviiklk
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 389-470 | 2.6e-08 | 26.1 | In-house | 276-361 (404) | alignment | ||
Range on Protein: 389-470
Range on HMM: 276-361/404.0
RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDD----HEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELR
|. . . .| .||| | .. ..|. |...|| ||. . ...| ||.|.|.| .|| ... .|. ... . |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkr
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 326-402 | 1.2e-07 | 23.8 | In-house | 213-294 (305) | alignment | ||
Range on Protein: 326-402
Range on HMM: 213-294/305.0
DSGTTAVVALIRGKQ-LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG----RVNGGLNLSRAIGD
| ... .|. .. | ||.|.|.. |.. |.. .||....|. || |.| ..|. | || . . ..| .||
dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 30-104 | 2.7e-07 | 23.0 | In-house | 10-99 (293) | alignment | ||
Range on Protein: 30-104
Range on HMM: 10-99/293.0
SAMQGWRVSMEDAHNCIPELD----------SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQK-----AYKEGKLQKALEDAFLAIDAK
. .| | |.||| . .|| | . ..|.|||.|. . ..|. | |... . || ...|.| |.| . | .
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdee
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 318-467 | 3.2e-06 | 19.6 | Pfam-A | 88-202 (212) | alignment | ||
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|.. .. ... | . |. ... . ....
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................
eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
.|. |. ... . .. ||... ....| . .... ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 318-467 | 3.2e-06 | 19.6 | In-house | 88-202 (212) | alignment | ||
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|.. .. ... | . |. ... . ....
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................
eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
.|. |. ... . .. ||... ....| . .... ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 35-107 | 4.4e-06 | 18.7 | In-house | 13-86 (492) | alignment | ||
Range on Protein: 35-107
Range on HMM: 13-86/492.0
WRVSMEDAHNCIPEL--DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALeDAFLAIDAKLTT
|. .|||.. . | ... |..|||. | | .|| |.... .. . . ... . . |.....||
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervsltt.avnlidnndltd
|