Gene PPM1G in Homo sapiens

Synonym: PP2CG, PP2CGAMMA, PPP2CG, PPM1G

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP180_AA protein Get Run
HsapP180_AA_20-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-507 6.4e-210 691.1 In-house 1-472 (473) alignment
Range on Protein: 4-507
Range on HMM: 1-472/473.0
YLSQPNTVKCSGDGVgapRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDA
|||.|.. | | |.    .  | ||.|||||||||.|||||||..||..|..|.|||||||.||| |.||.|||..|.||.||||...||||.||||.|.
ylskpkvekesedes...neelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe

KLTTEEVIKELAQIAGrPTEDEDEKekvADEDDVDNEEAALLHEEATMTIEELLTRYgqnchkgpphskSGGGTGEEPGSQGLNGEAGPEDSTRETPSQE
||..||..|||..||. ..|||||.   ...|. |..|..||.|||.....|||.|.            .| |...|  || |. .|  ||...|....|
klkaeeslkelkeiae.aeededee...eeddeededeiellteeaeipldellkrl............dgdgsekeelsqallegaasedeedededee

NGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLprvakskffEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEE
. ...|.....|...|. ..|.. |.. . .... ........|          |..|||..|.|||||..|...||||....||.|.||||.|.||.||
eeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeeke.........eeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeee

DDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDH
|.|.||......|.|.|||||.||||||||||...|.||||||||||||.|..|||||.|.||||||||||.||..|||||..|||||||||||||.|||
dgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDh

FYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgelrLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIII
.||.|..||..||||||||||||||||...||.|.|||||||||.|||||||...|.....|.     ||.|||||||.|||||||||||||||||.||.
aYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtviiv

CFKP
..|.
llkk

PP2Cc_SM00332 22-503 1.4e-98 322.6 In-house 7-274 (274) alignment
Range on Protein: 22-503
Range on HMM: 7-274/274.0
RLPLPYGFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG----KLQKALEDAFLAIDAKLTTEEVIKELA
.| |.||.|.|||||.||||||.....|.  .....|.|.|||||.||| ...|.||...|... .|..    . ..||..|||..| ....||  ||| 
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele

Qiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptakaytgfs
.                                                                                                   
n...................................................................................................

snsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeeeemmvp
                                                                                                    
....................................................................................................

gmegkeepgSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGkVTMDGRVNGGLNLSRAIGDHFYKRNKnlPPEE
         ..||.||||||.....|.|||.||||.|....|||...|.|||||||.|..|||.||| |...|||||||..|||.||||.|.||  ...|
.........alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.vvekgrvngglavsrafGdhflkknk..klke

QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengeLRLLSSIVEELLDQCLAPDtsgdGTGCDNMTCIII
..|.|.||.||.|||...||...|.||.|.|.|.|||||.........      .   . ..||||......    |...||.|....
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairr....ggseDniTvvvv

0034914 PP2C-like 21-507 9.2e-76 247.3 In-house 17-292 (295) alignment
Range on Protein: 21-507
Range on HMM: 17-292/295.0
PRLPLPYGFSAMQGWRVSMEDAHNCIPEL---DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-------KAYKEGKLQKALEDAFLAIDAKLTTEEV
  | | .|.. .||.| |.|||. ....|   ......| |.||||| ..| .....|.......         . .  ...||..||||.| .| .. .
lllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelal

IKelaqiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptaka
 .                                                                                                  
lr..................................................................................................

ytgfssnsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeee
                                                                                                    
....................................................................................................

emmvpgmegkeEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMdGRVNGGLNLSRAIGDHFYKRNKN
              . ||||||||||||..|.|||.||||.|..  |... ...|||| .| | .||..||| |.. |||||.|...||.||...|....
...........pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlkllls

LPPEEQMISALPDIKVLTLT-DDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFKP
|...|...|| ||..||.|| .|..|...|.||.|.|.|..|.||...| ......      |. ..|||.|..||      . ..||.|........
lllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsrDNiTvvvvrlng

subfamily_PPM1G2_pd Subfamily PPM1G2 324-505 7.6e-69 224.8 In-house 112-286 (287) alignment
Range on Protein: 324-505
Range on HMM: 112-286/287.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDgRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPD
 ...|.||||.||. ..|.||||||||.|.|..|..  .|.||||..| |  ||..||| | .. |||| | ||||.||. .|.|....||||.. |.||
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtavPD

IKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF
. |  |..|.||.|.||||||.|....||||......... .      |..|.|||||.|||||.|  | ||||||..|...
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_PPM1A_pd Subfamily PPM1A 274-506 2.2e-59 194.1 In-house 85-281 (282) alignment
Range on Protein: 274-506
Range on HMM: 85-281/282.0
SEECSEEEDGYSSEEAENEEDEDDTEEAEEDdeeeeeemmvpgmegkeepgsdsGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVE
.|  .. ..|. . . . .|...|...|..                        |.|||..|.. |.||.||.|||| |... |||  ...||||... |
devkealrqgfLaldeairelstdlktadks.......................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkE

LARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELrlls
  ||..|||.|.  .|||| | .|||.||..||.......|||..|| |.....  .....|.|.|||||| |.|..|||......... ||  |.    
kkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev....

siVEELLDQCLAPDTSgdgtgcDNMTCIIICFK
  ...|.|..|  ..       ||.......|.
..akalvdkalekgsr......DNlsvlvvlfa

PP2C Protein phosphatase 2C 320-489 3.1e-59 193.6 Pfam-A 94-252 (255) alignment
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
..   |.||.||||||||||.|.|||.||||.|.. ...|   ...||||.|| | .||..|||.|   ||||| |..|||.||...|...     ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv

SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. .       .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 320-489 3.1e-59 193.6 In-house 94-252 (255) alignment
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
..   |.||.||||||||||.|.|||.||||.|.. ...|   ...||||.|| | .||..|||.|   ||||| |..|||.||...|...     ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv

SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. .       .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse

PPM_PTC7 323-489 2.8e-58 190.4 In-house 97-256 (259) alignment
Range on Protein: 323-489
Range on HMM: 97-256/259.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVT--MDGRVNGGLNLSRAIGDHFYKRNKNlppEEQMIS
  |.||.|||||||.|..|.|||.||||.|..  |.|   ...||||..| | .||..|||.|    .||||| |..|||.||...|...    |||..|
epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvs

ALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengelrLLSSIVEELLDQCLAPDTS
| |||.. ......||...|.||.|.|.|.||.||...| .|..        .. . |.|.| ..|....
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargse

0049733 PP2C-like 323-506 5e-39 127.0 In-house 88-234 (235) alignment
Range on Protein: 323-506
Range on HMM: 88-234/235.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVtmdgRVNGGLNLSRAIGDHFYKrnknlppeeqmisalP
. . .||||||||..|..|.|||.||||...   ||.. ...||.| .| | .||..||| |    ||.|.| |.||.||...|               |
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............p

DIKVLTLTDDHeFMVIACDGIWNVMSSQEVVDFIQSkisqrdengelRLLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFK
|. ||.|.... |...|.||.|.|.|..|.||...|             |. ..|.|....||      . |.||.|.......
dvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrld

subfamily_PPM1E_pd Subfamily PPM1E 288-478 2.4e-37 121.5 In-house 66-245 (265) alignment
Range on Protein: 288-478
Range on HMM: 66-245/265.0
EAENEEDEDDTEEAEEDDEEEEEEMMVPGmegKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD
....|....|..|| ..  .. .|...      |. .  ||.||||.||...|| ||  |||. .. . |.|. .   ||||.| | .||..||| | . 
lvrqeklkedpaealkeafkltDerflqk...aereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi

G--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgELRLLSSIVEE
|  |||| |..||||||  .|         ...|. .|.  ..|....|....||||.|.|.  .|||. ... ...  |. . ..  ..||.
gawRvnGvLsvsRaiGDvklk.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaed.lsevakllvea

subfamily_PPM1L_pd Subfamily PPM1L 326-462 4.4e-32 104.4 In-house 105-238 (269) alignment
Range on Protein: 326-462
Range on HMM: 105-238/269.0
DSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrNKNlppeeqMISALP
 .||||..||.....||||| |||| |.  . |||. .|.||||..  |  |||.||| ....|  ||.| |  |||.||.  | .||      .. | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.dkn......lviadp

DIKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQ
||  . | |   ||...|.||.|. .| .| | ||. ....
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlke

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 325-464 1.3e-31 102.8 In-house 93-227 (255) alignment
Range on Protein: 325-464
Range on HMM: 93-227/255.0
SDSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMD---GRVNGGLNLSRAIGDHFYKrnknlpPeeqMISA
   ||||...|| ... ..|| |||| |..   | |  .|.|||| .| |  ||...||.|  .    |||| | .|||.|| | .      |    . .
kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle......P...fvvp

LPDIK-VLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSkISQRD
 ||..  |. . ...|...||||||...| .| |. . . ||. .
dPdlsqsleiskkdkflilacdGiwdlisdeeaveivag.isdpe

subfamily_ILKAP_pd Subfamily ILKAP 320-467 2.2e-30 98.8 In-house 106-250 (293) alignment
Range on Protein: 320-467
Range on HMM: 106-250/293.0
KEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVV---SEAGK---ALDMSYDHKPEDEVELARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKnlpp
|..|    |.||.| |.  . | ||| |||..|.   .|.|.   .. .. ||.| .. |  ||. |||.|. ||||.| |. ||.|||  .||      
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlG....

eeqmISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
    ... ||.| ..||..  |.|.||||.|.|.| .|||.||.. . ..... 
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr

PPM_PTC7_SpoIIE 320-463 2.6e-28 92.4 In-house 87-212 (230) alignment
Range on Protein: 320-463
Range on HMM: 87-212/230.0
KeepGSDSGTTAVVALIRGKQ--LIVANAGDSRCVVSEA-GKaldmsydhkpedevELARIkNAGGKVT---MDGRVNGGLNLSRAIGDHFYKRnknlpp
.    |.||.|||||||.. .  | |||||||..... . |.              |  ||  ||| .    ..|||.| |..|.|.|| ...       
e...psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......

EEQMISALPDiKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQR
......| ||  . ..... .||...|.||.|.|.|.||.||.... ... 
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp

subfamily_PPM1K_pd Subfamily PPM1K 325-458 1.2e-26 86.4 In-house 96-227 (263) alignment
Range on Protein: 325-458
Range on HMM: 96-227/263.0
SDSGTTAVVALIR-GKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD----GRVNGGLNLSRAIGDHFYKRNKnlppeeqmIS
  ||||| |.|.| |..|..|. |||| ..   |||  .. ||.|| | |  |||.|||.|...     .||| | ..|..||   ||          . 
lssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........vi

ALPDIKVLTL-TDDHEFMVIACDGIWNVMSSQEVVDFIQS
| |. | | .  ..  |.|.  ||| .|..|||. |... 
atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl

subfamily_PPM1G2_pd Subfamily PPM1G2 27-113 1.4e-26 86.1 In-house 21-112 (287) alignment
Range on Protein: 27-113
Range on HMM: 21-112/287.0
YGFSAMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKE
 | |||||.|..|||||   .||     |...|.|.|.|||||..|| |..| |  .|. .|..|||.|...|.||||..| .|. .| .|.
vgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkd

subfamily_KAPP-like_pd Subfamily KAPP-like 327-467 1.1e-23 76.6 In-house 100-239 (266) alignment
Range on Protein: 327-467
Range on HMM: 100-239/266.0
SGTTAVVALIR--GKQ--LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAl
 |.|| .||.   |.|  | ||| |||   .|   ..| .|.||| .|. |  |||. |  .. .  |.| || .|||.|||| |.  |.     .||  
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.

PDI-KVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
| . . ..||  ..|...| ||.|.|.| .. .. ..|   |.. . 
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqated

subfamily_PDP_pd Subfamily PDP 324-469 4.5e-23 75.0 In-house 149-321 (398) alignment
Range on Protein: 324-469
Range on HMM: 149-321/398.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVS---EAG--KALDMSYDHKPEDEVELARIKNAGG-----KVTMDGRVNGGLNLSRAIGDHFYKRNKNLPP
 . ||..|..|||.|..| |||.||.|.|.    | |  .|  .| |.  . | |. |||..        | ..||. | |  .|| ||  || ...|  
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqk

-------------EE----QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGEL
             ..      ..| |..    |. .  |.|.| ||.|...|..|||. ..  .....|. ..
kvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 339-467 1.1e-21 69.9 In-house 126-249 (276) alignment
Range on Protein: 339-467
Range on HMM: 126-249/276.0
KQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAlPDI-KVLTLTDDHEFM
. | ||| |||   .|   ..| .|.||| .|  |  |||. |  .. .  |.| || .|||.|||| |.  |.     .||  | . . ..||  ..|.
rylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.pyvsnrilltpfdkfl

VIACDGIWNVMSSQEVVDFIQSKISQRDENG
..| ||.|.|.| .. .. ..|   |.. . 
ivasdGlwdvisGkdaiekvkslydqqated

subfamily_PPM1A_pd Subfamily PPM1A 23-111 1.7e-20 66.6 In-house 10-108 (282) alignment
Range on Protein: 23-111
Range on HMM: 10-108/282.0
LPLPYGFSAMQGWRVSMEDAHNCIPELDSE--TAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAY--------KEGKLQKALEDAFLAIDAKLTTEEVI
..| || |.||||||.|||||... .| .    ..|.|.|||.|.||| |..| |.. | .....        .. ....||...|||.| .. ...  
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

subfamily_PP2D1_pd Subfamily PP2D1 326-463 5.8e-18 57.8 In-house 175-309 (492) alignment
Range on Protein: 326-463
Range on HMM: 175-309/492.0
DSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKV---TMDGRVNGGLNLSRAIGDHfykRNKNLppeEQMISALP
..  .  | |.    | .||||. . |.  .|||  .  .| |... |  |...||. |      |.||| |.  | .| .    . .|   .. .   |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQR
 ..  .|..   |.|.|  |.|.|.| .||.  ... . . 
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy

PPM_PTC7 27-107 2.9e-17 56.0 In-house 3-91 (259) alignment
Range on Protein: 27-107
Range on HMM: 3-91/259.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA--IDAKLTT
.|.||.||.|.|||||| . .     . ... | |.|.||||| |.| |... |..|.| .|  .|. ||.||| ..|||  .| .|..
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks

PP2C Protein phosphatase 2C 27-107 3.2e-17 55.9 Pfam-A 3-90 (255) alignment
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ...     . .|. |.| |.|||||.|.| |... |..|.| ||  .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

PP2C Protein phosphatase 2C 27-107 3.2e-17 55.9 In-house 3-90 (255) alignment
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ...     . .|. |.| |.|||||.|.| |... |..|.| ||  .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

subfamily_TAB1_pd Subfamily TAB1 327-449 1.7e-15 49.6 In-house 129-262 (333) alignment
Range on Protein: 327-449
Range on HMM: 129-262/333.0
SGTTAVVALIRGKQLIVANAGDSRCVVSE---AGKALDMSYDHKPEDEVELARIKNAGG---KVTMDGRVnGGLNLSRAIGDHF----YKRNKNLP-PEE
 |||||||||  ..| |||.|||| .. .     |   .| ||. . | || |.|. |    ..   .|. |. .  |.|||.     || .. |   ..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QMISALPDIKVL-TLTDDHEFMVIACDGIWNVMSS
. . | |||.    ..|   |.|.  ||. . .  
ePviaePdiqgaypiddityflvlmSdGvyktLee

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 325-404 3.1e-15 49.5 In-house 83-184 (292) alignment
Range on Protein: 325-404
Range on HMM: 83-184/292.0
SDSGTTAVVALIRGK-QLIVANAGDSRCVVSE-----AGKALDMSYDHKPEDEVELARIKNAGGKVT----------MDGRV------NGGLNLSRAIGD
  ..|..| | .|   .||.|| ||||...         .   .| ||||||  | |||..|||.|.             ||      .|.| ||||.||
esattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd

HF
  
fh

PPM_PTC7_motif 437-489 1.1e-13 44.4 In-house 1-48 (51) alignment
Range on Protein: 437-489
Range on HMM: 1-48/51.0
VIACDGIWNVMSSQEVVDFIQSKIS-QRDengelrLLSSIVEELLDQCLAPDTS
..|.||.|.|.|.||.||.... .| ...       . .. |.| |..||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl......spqeaAeklvdealargse

subfamily_PHLPP_pd Subfamily PHLPP 340-458 1.8e-13 43.0 In-house 106-214 (246) alignment
Range on Protein: 340-458
Range on HMM: 106-214/246.0
QLIVANAGDSRCVVSEAGKALDMSYDHKPEDEvELARIKNAGGKVTMDGRVNGGLNLSRAIGdHFYKRNKNLPPeeqmisalPDIKVLTLTDDHEFMVIA
.| ||. |    |.   || | .|  .. |.. || |||.| . .| |...|| .. .| .| ...     ||         | .. ..||.. |.... 
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdellivG

CDGIWNVMSSQEVVDFIQS
 . .|.|.| .|.|. .. 
nkalWevlsideaveavrk

subfamily_PPM1D_pd Subfamily PPM1D 394-506 1.8e-13 43.2 In-house 201-308 (309) alignment
Range on Protein: 394-506
Range on HMM: 201-308/309.0
LNLSRAIGDHFyKRnkNLPPEEQMISALPDIKVLTLTDDHE-FMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRllSSIVEELLDQCLApDTSGDG
|...|..|| .     |   .| ..|  ||.|| ||. ..| |...| ||.|||......|...... ...  ..|    .|... |... |   ..   
LavaRslGDlW.sy..naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealq.rwrskk

TGCDNMTCIIICFK
  .||.. |.....
lraDnvsvivvile

subfamily_PPM1D_pd Subfamily PPM1D 324-387 1.1e-12 40.7 In-house 105-174 (309) alignment
Range on Protein: 324-387
Range on HMM: 105-174/309.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGK------ALDMSYDHKPEDEVELARIKNAGGKVTMD
 | .|||| | .||...| ||. |||. |..   .      |  .  |||||.  |  ||...||.|.. 
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak

0049733 PP2C-like 25-108 2.5e-12 39.9 In-house 3-82 (235) alignment
Range on Protein: 25-108
Range on HMM: 3-82/235.0
LPYGFSAMQGW-RVSMEDAHNCipeldsETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-KAYKEGKLQKALEDAFLAIDAKLTTE
| .|.. ..|. |  .|||. .      ....| |.||||| ... .....|....... ... . .|..||..||||... |  .
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel

subfamily_PPM1E_pd Subfamily PPM1E 30-108 5.4e-12 38.4 In-house 9-94 (265) alignment
Range on Protein: 30-108
Range on HMM: 9-94/265.0
SAMQGWRVSMEDAHNCIPEL----D----SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLqKALEDAFLAIDAKLTTE
 |... |  ||| | ....|    .    .|.|.|.|.||||| | | | |. |.  . .|.  ||  . .||..|| ..| .... 
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk

subfamily_PPM1K_pd Subfamily PPM1K 28-107 1e-11 37.4 In-house 7-84 (263) alignment
Range on Protein: 28-107
Range on HMM: 7-84/263.0
GFSAMQGWRVSMEDAhNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKaYKEGKLQKALEDAFLAIDAKLTT
|. ...| |   ||   .. ||| |   ..|.|||.|   | .. . |  |.|. .  || .|.. | .||. .| ||. 
GkdsliGkraenedr.iklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr

PPM_PTC7_SpoIIE 27-108 2.6e-11 36.8 In-house 3-87 (230) alignment
Range on Protein: 27-108
Range on HMM: 3-87/230.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEvaLYCAKYLPDIIKDQKaYKEGK-LQKALEDAFLAIDAKLTTE
.|.||.||.| |||||| . .       ..  ... ..||||| .   .... | .... .. ....  . ..|....||..|.|..|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede

subfamily_PPM1H_pd Subfamily PPM1H 244-372 9.1e-11 34.1 In-house 80-207 (404) alignment
Range on Protein: 244-372
Range on HMM: 80-207/404.0
ASDKLPRVAKSKFFEDSEdESDEAEEEEEDSEECSEEEDGYSSEEAENEED---EDDTEEAEEDDEEEEEEMMVpgmEGKEEPGSDSGTTAVVALIRGKQ
|| .| .. |.|. .  |    | ..|||.  |.|..|. .| .|  .|..   |.    | |.   | .|..    . .|.     | ||.|||.  ..
askllhkhlkekledvle.llleksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqia...rereayrikGGCtalvalvllgk

LIVANAGDSRCVVSEAGKALDMSYDHKPEDEV
| |||||||| .... ..  ..| |. || | 
lYvanaGDsRailvrkdeiiplsadftPeteR

subfamily_PPM1D_pd Subfamily PPM1D 31-106 1.1e-10 34.1 In-house 8-91 (309) alignment
Range on Protein: 31-106
Range on HMM: 8-91/309.0
AMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYK---EGKLQKALEDAFLAIDAKLT
| || |  |||      |      . | |...|.|||||.| | .  . |   ||.|| .    . ....|...||||.  .. 
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamk

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 28-107 2.1e-09 30.0 In-house 9-90 (255) alignment
Range on Protein: 28-107
Range on HMM: 9-90/255.0
GFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTT
||| | | | .|||      .    |.  .....|||||.. | .... |. |...    .. . .|.|..|. .|. ... 
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqise

PP2C_SIG_SM00331 323-503 2.1e-09 30.3 In-house 82-215 (217) alignment
Range on Protein: 323-503
Range on HMM: 82-215/217.0
PGSDSGTTAVVALI--RGKQLIVANAGDSRCVVSEAGKAL-DMSYdhkpedevelariknaggkvtmdgrvngglNLSRAIG-----Dhfykrnknlppe
  .....|...||.  ....| .|||||||...   ||   . .                               ......|     .            
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs............

eqmisalPDIKVLTLTDdHEFMVIACDGIWNVMSSQE-----VVDFIQSKIsqrdeNGELRLLSS-IVEELLDQCLAPDTsgdgtgCDNMTCIII
       .||. |.|    ...... ||.....|...     . ......      . |.. |.. |||||| .  .. .       |..| ...
.......vdirelelek.gdllllytDGltearsekgfaeerleeiledlv.....dseaqelaqkiveellelakgsng......eDdiTvvvv

subfamily_PPM1L_pd Subfamily PPM1L 31-119 4.6e-09 28.9 In-house 11-107 (269) alignment
Range on Protein: 31-119
Range on HMM: 11-107/269.0
AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPDIIKDQK----AYKEGKL----QKALEDAFLAIDAKLTTEevIKELAQIAG
...| |  |||  .   ... .|   .|.|.||||||  | .. . |.. ||..     | || ..    .| |.|  |..| || ..  .|   .|||
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek..akraediaG

Subfamily Dicty-PPM1L-like 389-506 2.4e-08 26.2 In-house 200-304 (305) alignment
Range on Protein: 389-506
Range on HMM: 200-304/305.0
RVNGGLNLSRAIGDHFYKRNKNlPPEEQMIsalpdiKVLTLTDDhEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDT
.||. |. || .||   |     |.... .      .|.. ..| .|.|.| ||.|.|.| |.||.... .. ..  .. .      . ..  .      
lvnrllkksrskGdknlkelvi.Pnndspl......lvvakanD.qflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrg

SGDgtgcdNMTCIIICFK
|||     |.| .|| .|
sgD.....nitlviiklk

subfamily_PPM1H_pd Subfamily PPM1H 389-470 2.6e-08 26.1 In-house 276-361 (404) alignment
Range on Protein: 389-470
Range on HMM: 276-361/404.0
RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDD----HEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELR
|. . .  .| .|||  |  ..      ..|. |...|| ||.      . ...| ||.|.|.| .||   ... .|. ... . |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkr

Subfamily Dicty-PPM1L-like 326-402 1.2e-07 23.8 In-house 213-294 (305) alignment
Range on Protein: 326-402
Range on HMM: 213-294/305.0
DSGTTAVVALIRGKQ-LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG----RVNGGLNLSRAIGD
| ... .|.    .. | ||.|.|.. |..  |..  .||....|.  || |.|  ..|.  |     || . . ..| .||
dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD

subfamily_ILKAP_pd Subfamily ILKAP 30-104 2.7e-07 23.0 In-house 10-99 (293) alignment
Range on Protein: 30-104
Range on HMM: 10-99/293.0
SAMQGWRVSMEDAHNCIPELD----------SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQK-----AYKEGKLQKALEDAFLAIDAK
.  .| |  |.|||  . .||          |  . ..|.|||.|.  . ..|. |   |...      . || ...|.| |.| . | .
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdee

PP2C_2 Protein phosphatase 2C 318-467 3.2e-06 19.6 Pfam-A 88-202 (212) alignment
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|..  .. ... | . |. ... .  ....                              
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................

eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
        .|. |. ... .  ..  ||... ....| . ....  ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg

PP2C_2 Protein phosphatase 2C 318-467 3.2e-06 19.6 In-house 88-202 (212) alignment
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|..  .. ... | . |. ... .  ....                              
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................

eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
        .|. |. ... .  ..  ||... ....| . ....  ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg

subfamily_PP2D1_pd Subfamily PP2D1 35-107 4.4e-06 18.7 In-house 13-86 (492) alignment
Range on Protein: 35-107
Range on HMM: 13-86/492.0
WRVSMEDAHNCIPEL--DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALeDAFLAIDAKLTT
|. .|||..    .   | ... |..|||. |   |  .|| |.... .. .  . ... .  .  |.....|| 
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervsltt.avnlidnndltd