Gene PPM1H in Homo sapiens

Synonym: ARHCL1, NERPP-2C, URCC2, PPM1H

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1H
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP181_AA protein Get Run
HsapP181_AA_62-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1H_pd Subfamily PPM1H 67-508 1.2e-199 656.1 In-house 2-403 (404) alignment 
Range on Protein: 67-508
Range on HMM: 2-403/404.0
ILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKK--AGAVTSTPnrnsskrrsslpngeglqlKENSESEGVSCHYWSLFDGHAGSGAAVVASR
...|.||||||.|||||||||||..|||||...||..||.  . .|||.|                   ||.||.|.....|..|||||||||||.|||.
vprelrrlPwaaGYaevinagkselneDqaaakvlllkkekkeksvtskp...................kekseeeklplayfglfDGhaGsgaalvask

LLQHHITEQLQDIVDILKNSAVlpptclgEEPENTPANSrtltraaslrggvgaPGSPSTPPTRFfTEKKIPHECLVIGALESAFKEMDLQIERERSSYN
||..|..|.|.|....|....        ||.|||...|               . |||...... .||.|..|.||||||||||.||| ||.|||..|.
llhkhlkekledvlellleksa.......eeeenteess...............kespssvseiy.eekeiskeeLviGalesaflemDeqiarereayr

ISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIE
|.||||||....||||||||||||||||..|..||||.|..|||||||||||.|||..|.|||.|||.|||..|...|.||...||||.|||||||||.|
ikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqRlqelaflkPeLlgkeftrlefqkRlkkkdlgqrvlyRdqnmtGWayktve

DEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDP
.||||||||.|||||||..||||||||||||.|||.|.|..||||||..||||..||..... .||||||||||||||||||||||.....|....|.|.
eeDlkfplisgegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedk

HRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLI
.||| .||.||..|||.|||.|||..... .|.|||||.||||.
krytavaqeLvaaarGklkdkgWrlkeekaasvDDisvfviPlk
0034914 PP2C-like 63-507 6.4e-56 182.3 In-house 6-290 (295) alignment 
Range on Protein: 63-507
Range on HMM: 6-290/295.0
RPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVltvkkkagavtstpnrnsskrrsslpngeglqlkeNSESEGVSCHYWSLFDGHAGSGAAVVA
.|.| |  .. |.. . .. . . |.. .|||. .. .                                   |  |   ..... .|||| |. || ||
lpllellllsslllllrvgvasdqGrrksneDavlvvl...................................nllslledlllfgvfDGhgGhaaaeva

SRLLQHHITEQLQDIVDILKNSavlpptclgeepentpansrtltraaslrggvgapgspstpptrfftekkiphECLVIGALESAFKEMDLQIERERSS
|.|| ... |.|. .. .| .|                                                     .  .. ||..||...| .. ..  .
sellvelllellekllllltls.....................................................ledieealrkaflaadeellelall

--YNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTP--ETERQRLQYLAfmqphllgnefthlefprrvqrkelgkkmlyrdfnmtgw
  . . .|.||....   .||||||.|||||...||||..... . .|  |.||.|.. .                                        
rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsag.......................................

ayktiededlkfpliyGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSkydHGSDDVLILATDGLWDVLSNEEVAEAITQFLPN
                |     ||. .. ||| |||.|||.. |.....|..|. |.|....|.   ...||.|.||.|||||||||||... ....| .
................gavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvlelt...ledddfllLasDGlwdvlsneeivdivrsllak

CDPddphrYTLAAQDLVMRARGvlkdrgwrisndrLGSGDDISVYVIPL
...     .. ||. || .|                || |.|.| |. |
gld.....leeaaeeLvdlAla.............rgsrDNiTvvvvrl
PP2Cc_SM00332 129-505 4.6e-45 147.1 In-house 35-274 (274) alignment 
Range on Protein: 129-505
Range on HMM: 35-274/274.0
EglqlkensesEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILknsavlpptclgeepentpansrtltraaslrggvgapgspstpptr
           |  . .. ..||||.|| .| ..|. | ... |.|.   | |                                               
v..........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...............................................

fftekkiphECLVIGALESAFKEMDLQIERERSSYNI---SGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTP--ETERQRLQYLAFmqp
         |  |  ||..||...| .|  | .| .    . |.||....   ..|||||.|||||...|||.....| . .|  |.||.|..  .    
.........eddveealkkaflstdeeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg...

hllgnefthlefprrvqrkelgkkmlyrdfnmtgwayktiededlkfpliygEGKKARVMATIGVTRGLGDHDLKVHDsnIYIKPFLSSAPEVRIYDLsk
                                                      .| ||  .. |.| .|||.||  .     .|.... |.| . .|  
....................................................vvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvvtl..

ydHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCdpdDPHRYTLAAQDLVMRARGVlkdrgwrisndrLGSGDDISVYVI
    .|..||||.|||||||||.|| . ....| .      .... ||..|.. |.               || |.|.| |.
..tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr............ggseDniTvvvv
0049733 PP2C-like 81-506 1.5e-37 122.2 In-house 6-232 (235) alignment 
Range on Protein: 81-506
Range on HMM: 6-232/235.0
AEVINAGK-STHNEDQASCevltvkkkagavtstpnrnsskrrsslpngeglqlkensesegvSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDivd
. .   |.  ..|||   .                                            ..... ..||| |. |. |||.|| ... |.|..   
gaasdigrvrkvneDavlv............................................glllfavaDGhgghaagevasellvetllellle...

I---LknsavlpptclgeepentpansrtltraaslrggvgapgspstpptrfftekkipheclVIGALESAFKEMDLQIERERSSY--NISGGCTALIV
                                                                .. ||..||.... .. ..  ..     .|.||...
lllld...........................................................leealrkaflaaneallelalaspelagmgtTavva

ICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTP--ETERQRlqylafmqphllgnefthlefprrvqrkelgkkmlyrdfnmtgwayktiededlkfpl
.   |||||||.|||||...|.|...... . .|  |.||||                                                          
lldggklyvanvGDsrayllrdgklvqltedhspvnelerqr..........................................................

IYGEGKKARVMATIGVTRGLGDHDLKvhdsniyikpflssapevriYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQflpncdpddpHRYTLAAQ
|. .|   ||.  . .|| |||..||                    .|.. ..  ..|.|.||.||||||||.||... ...          . .  ||.
iitaggavrvpgrlaltralGdlllk....................pdvtvlelepgdflllasDGlwdvlsdeeivdllrs..........ldleeaae

DLVMRARGvlkdrgwrisndrLGSGDDISVYVIP
 || .|.               |. |.|.| |. 
rlvelala.............rggrDNiTvvvvr
PPM_PTC7_SpoIIE 241-457 1.2e-17 57.5 In-house 69-210 (230) alignment 
Range on Protein: 241-457
Range on HMM: 69-210/230.0
VIGALESAFKEMDLQIERErssyNISGGCTALIVICLLGK--LYVANAGDSRAIIIRNGEIipmsseftpeterqrlqylafmqphllgnefthlefprr
.  .|. .. ... ..| |    ..|.|.||....    .  |||||||||.....|...                                        
peeilrrlnlalaadlede....psssgaTavvalidpstgklyvanaGdsppllvrddgg.......................................

vqrkelgkkmlyrdfnmtgwaykTIED-------------EdlkfpliygegkkaRVMATIGVTRGLGDHDLKVHDSNIyikpflssapEVRIYDLSKYD
                       ..|              .              ||  .  |..  ||  |.  |  .          | . ..  . .
.......................ererivagglpslGilpg..............rvfgvlavslapGdllllytDGvv..........eaepdtsdgel

HGSDDVLILATDGLWDVLSNEEVAEAITQFLP
 | |. ||||.||||||||..|..... . | 
fgkdeflilasdglwdvlspqelvdlvrdele
subfamily_PPM1G2_pd Subfamily PPM1G2 138-313 1.7e-17 56.3 In-house 46-161 (287) alignment 
Range on Protein: 138-313
Range on HMM: 46-161/287.0
ESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEqlqdivdilknsavlpptclgeepentpansrtltraaslrggvgapgspstpptrffteKKIPH
.|.  |. ....|||| |. .|  |.. |.. |..                                                            ||  .
ksddkslalfavfDGhGGakvakyagkklikkiak............................................................kksfk

ECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQ
|  .  .|. ||.|.| .. ....  . | |.||..|.    ||||||||||||..  .|..  .| .  |..|  
egaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeese
PPM_PTC7 239-314 5.6e-16 51.7 In-house 69-149 (259) alignment 
Range on Protein: 239-314
Range on HMM: 69-149/259.0
C-LVIGALESAFKEMDLQIERERSSYN---ISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEII-PMSSEFTPETERQR
. ... ||  .| ..|. .| ..|. |   ...|.||....    ||||||.|||||...|.|... ...  ..|. |. |
leklekalrksflaldtdeelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEr
subfamily_PPM1A_pd Subfamily PPM1A 379-459 3.8e-15 49.0 In-house 174-250 (282) alignment 
Range on Protein: 379-459
Range on HMM: 174-250/282.0
KARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKydhgSDDVLILATDGLWDVLSNEEVAEAITQFLPNC
. ||. .. |.| |||...| ...    .  .|. |||.. . |.    .|| |.|| ||.|||||.|||.| ... |   
vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierse....eddflvlacDGiwDvlsdeevvelvrkrleva
subfamily_PPM1D_pd Subfamily PPM1D 136-456 5.7e-15 48.2 In-house 27-265 (309) alignment 
Range on Protein: 136-456
Range on HMM: 27-265/309.0
NSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQlQDIVDIlKNSAVlpptclgeepentpansrtltraaslrggvgapgspstpptrfftekki
....| ..  . ..|||| |  ||  |.. | . |..| ....   ....|                                                 
eesaeelevafvavfDGHGGkeAakfarehlwsvikkq.kkflss.epedv.................................................

pheclvIGALESAFKEMDLQIERERSSY-------NISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEiipmsseftpetERQRLQYLAFMQPHLLgn
      . |...|| ..  .........           | || .||.   |||||. |||....  . .            . ..|.    .. |    
......leAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep............kekklrakeltkdHkP..

efTHLEFPRRVQrkEL-GKKMLYRDFNMTGWAYKTIEDEDLkfpliygegKKARVMATIGVTRGLGDHDLKVHDSNIYIkpfLSSAPEVRIYDLskyDHG
   ..|  .|..  || |. .  .  .   |  . .| ..          ..   .  . |.| |||     . |. ..    |  |.|  . |   |  
..espeekerie..elGGevaaksGvkRvvWkRprlehngp.........tvideiPFLavaRslGDlWsynaksgefv...vsPePdvkvrtl...dpn

SDDVLILATDGLWDVLSNEEVAEAITQFL
.....|||.||||.||. |.. . ...  
eekfiilasDGlwnvltpedavsvvekee
subfamily_PPM1A_pd Subfamily PPM1A 144-314 5.7e-15 48.4 In-house 42-164 (282) alignment 
Range on Protein: 144-314
Range on HMM: 42-164/282.0
CHYWSLFDGHAGSGAAVVASRLLQHHITEqlqdivdilknsavlpptclgeepentpansrtltraaslrggvgapgspstppTRFF--TEKKIPHECLV
  ....||||||| .| .... |...|.|                                                      .  .  ....  ..  |
wsfFavfDGHaGsevakyvkkhllenile......................................................eeelkeaaleasekdev

IGALESAFKEMDLQIERERSSYNI--SGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPET--ERQR
  ||...| ..| .|... ....     |.||. |.    .|..||.|||||...|||. . ....  |..  |..|
kealrqgfLaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkR
subfamily_PPM1L_pd Subfamily PPM1L 136-314 2.1e-14 46.4 In-house 27-154 (269) alignment 
Range on Protein: 136-314
Range on HMM: 27-154/269.0
NSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVlpptclgeepentpansrtltraaslrggvgapgspstpptrfftekkI
. ...... .. ..|||| |  ||  |  .| . | ..|...    .|.                                                  |
ediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentep................................................i

PHECLVIGALESAFKEMdlqIERERSSYNISgGCTALIVICLLGKLYVANAGDSRAIII-RNGEIIPMSSEFTPETERQR
 .. |.   . |. ...   .|. .....|. |.|||| .    .| ||| |||| ... ..|. ||.| .  |.  ..|
nfsklltdeilsvdekl...lekakraedia.GttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvker
PP2C Protein phosphatase 2C 379-458 2.1e-14 46.7 Pfam-A 161-231 (255) alignment 
Range on Protein: 379-458
Range on HMM: 161-231/255.0
KARVMATIGVTRGLGDHDLKVHDsniyiKPFLSSAPEVRiydLSKYDHGsDDVLILATDGLWDVLSNEEVAEAITQFLPN
. ||  .. |.| |||..||  .     ... |..|.|.     | .   |. ||||.||||||||..|... ....|  
ngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselsk
PP2C Protein phosphatase 2C 379-458 2.1e-14 46.7 In-house 161-231 (255) alignment 
Range on Protein: 379-458
Range on HMM: 161-231/255.0
KARVMATIGVTRGLGDHDLKVHDsniyiKPFLSSAPEVRiydLSKYDHGsDDVLILATDGLWDVLSNEEVAEAITQFLPN
. ||  .. |.| |||..||  .     ... |..|.|.     | .   |. ||||.||||||||..|... ....|  
ngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselsk
PP2C Protein phosphatase 2C 240-314 6.1e-14 45.2 Pfam-A 71-150 (255) alignment 
Range on Protein: 240-314
Range on HMM: 71-150/255.0
LVIGALESAFKE-MDLQIERERSS-YNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEII-PMSSEFTPET--ERQR
.|  || ..| . .| ...... .   .. |.||....    ||||||.|||||...|.....  ..   .|.   ||.|
kvekalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreR
PP2C Protein phosphatase 2C 240-314 6.1e-14 45.2 In-house 71-150 (255) alignment 
Range on Protein: 240-314
Range on HMM: 71-150/255.0
LVIGALESAFKE-MDLQIERERSS-YNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEII-PMSSEFTPET--ERQR
.|  || ..| . .| ...... .   .. |.||....    ||||||.|||||...|.....  ..   .|.   ||.|
kvekalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreR
PPM_PTC7 379-457 5.8e-13 41.9 In-house 164-235 (259) alignment 
Range on Protein: 379-457
Range on HMM: 164-235/259.0
KARVMATIGVTRGLGDHDLKVHDSniyIKPFLSSAPEVRiydLSKYDHGsDDVLILATDGLWDVLSNEEVAEAITQFLP
. ||  .. |.| .||..||   .    .. .|..|..      | |   |. ||||.||||||.|..|... ....| 
ngrvngvlavsRafGdfelkpket...eeqlvsaePdis...stkidee.defliLasdGlwdvvsdqeavdlvrsels
PP2C_SIG_SM00331 244-505 2.3e-12 40.0 In-house 65-215 (217) alignment 
Range on Protein: 244-505
Range on HMM: 65-215/217.0
ALESAFKEMDLQIERErsSYNISGGCTALIVI--CLLGKLYVANAGDSRAIIIR-NGEIIPMSSeftpeterqrlqylafmqphllgnefthlefprrvq
.|..|.|...  |..|  . . ....|.|. .     |||..||||||| ...| .... . ..                                    
elsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd....................................

rkelgkkmlyrdfnmtgwayktiededlkfpliygegkkarvmatigvtrglgdhdlkvhdsniYIKPFLSSAPEVRiYDLSKYDHGSDDVLILATDGLW
                                                                   . |.  |||. .| .. .   .|.|.|.||||.
................................................................vegaplGlepevs.vdirelelekgdllllytDGlt

DVL-----SNEEVAEAITQFLpNCDPDDPHRytLAAQDLVMRARGVLKdrgwrisndrlgsGDDISVYVI
..       .|.. |...... .. ... ..     ..|. .|.|  .              |||.| |.
earsekgfaeerleeiledlv.dseaqelaq..kiveellelakgsng.............eDdiTvvvv
subfamily_PPM1G_pd Subfamily PPM1G 252-313 2.8e-11 36.1 In-house 281-342 (473) alignment 
Range on Protein: 252-313
Range on HMM: 281-342/473.0
MDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQ
. |. . |. .   . |.|| ...    ||.||||||||... |||. . .| .  || |  
eeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevE
subfamily_PP2D1_pd Subfamily PP2D1 373-457 4.6e-11 35.1 In-house 233-307 (492) alignment 
Range on Protein: 373-457
Range on HMM: 233-307/492.0
IYGEGKKARVMATIGVTRGLGDH-DLKVHDSnIYIKPFLSSapeVRIydlSKydhgSDDVLILATDGLWDVLSNEEVAEAITQFLP
.. ..|...|   ...||||| . |.|.. | . ..| . |   | .    .     . .|.||. |||.|||.|||.. ..|.|.
vvkseknglvnGildttRGLGnyGdpkLkks.vipePktts...vkl...de....aaqflvlAsnGlWevlseeevlsLvkqtla
subfamily_PDP_pd Subfamily PDP 403-465 7.3e-11 34.8 In-house 263-321 (398) alignment 
Range on Protein: 403-465
Range on HMM: 263-321/398.0
NIYIKPFLSSAPEVRIYDLSKydhgSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPH
. .  |.|.. |||  . |..    .|  |.||||||||.||||||.. ....| . . ..| 
dyktPPYltaePevtshklre....ndkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PPM1E_pd Subfamily PPM1E 240-314 1.1e-10 34.2 In-house 77-149 (265) alignment 
Range on Protein: 240-314
Range on HMM: 77-149/265.0
LviGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQR
.   ||..|||..| .. .   . .. .|.|| .|.    .||||  |||.|...|.||.. . .   || |. .
a..ealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEk
subfamily_PPM1E_pd Subfamily PPM1E 380-459 6.8e-10 31.6 In-house 165-231 (265) alignment 
Range on Protein: 380-459
Range on HMM: 165-231/265.0
ARVMATIGVTRGLGDHDLkvhdsniyiKPFLSSAPEVRIYDLSkydhGSDDVLILATDGLWDVLSNEEVAEAITQFLPNC
 ||  .. |.| .|| .|         ||..|. ..|  ..|     ||...||||.||||||. .||| .....|| . 
wRvnGvLsvsRaiGDvkl.........kpyvsgeadvaeveld....gseeylilacDGlwDvvneeevvklveefladg
subfamily_TAB1_pd Subfamily TAB1 262-296 1.3e-09 30.3 In-house 124-158 (333) alignment 
Range on Protein: 262-296
Range on HMM: 124-158/333.0
SYNISGGCTALIVICLLGKLYVANAGDSRAIIIRN
  .|||| ||.... .  ||||||.|||||.....
eeeisgGttAvvalifnnkLyVaNvGdsrAllvkr
subfamily_PPM1L_pd Subfamily PPM1L 381-456 2.1e-09 30.0 In-house 171-236 (269) alignment 
Range on Protein: 381-456
Range on HMM: 171-236/269.0
RVMATIGVTRGLGDHDLKvhDSNIYIkpflsSAPEVRIYDLSKYDhgsDDVLILATDGLWDVLSNEEVAEAITQFL
||   . ..| |||. ||  | |. |     . |..  .|| ...    . ||||.||||| .||||  . | . |
rvaGvlatsralGdyplk..dknlvi.....adpdiltfdlddhk...peflilasdGlwdtfsneeavrfikerl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 379-454 4.9e-09 28.8 In-house 159-222 (255) alignment 
Range on Protein: 379-454
Range on HMM: 159-222/255.0
KARVMATIGVTRGLGDhdlkvhdsnIYIKPFLSSAPEVRIydlSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQ
 .||  |. |.| |||         ....||. . |..     |   . .|  |||| ||.||..|.||  | . .
tsrvnGtlavsralGd.........sflePfvvpdPdlsq...sleiskkdkflilacdGiwdlisdeeaveivag
subfamily_PPM1G2_pd Subfamily PPM1G2 379-454 5.5e-09 28.4 In-house 174-245 (287) alignment 
Range on Protein: 379-454
Range on HMM: 174-245/287.0
KARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSkydhGSDDVLILATDGLWDVLSNEEVAEAITQ
  ||  .. . | |||.  | ...           |.| . .|.     .|. |.|| ||.||||.|.|| . . .
lnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkld....eddeflvLaCDGiWDvltnkevvdlvre
PPM_PTC7_motif 433-476 1.9e-08 27.7 In-house 1-40 (51) alignment 
Range on Protein: 433-476
Range on HMM: 1-40/51.0
ILATDGLWDVLSNEEVAEAITQFLP-NCDpddphRYTLAAQDLVM
|||.||||||||..|. . ....|  . .     ... ||..|| 
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvd
subfamily_PPM1K_pd Subfamily PPM1K 245-314 2.2e-08 26.5 In-house 71-148 (263) alignment 
Range on Protein: 245-314
Range on HMM: 71-148/263.0
LESAFKEMDLQIERERSSY-----NISGGCTALIVICLLG-KLYVANAGDSRAIIIRNGEIIPMSSEFTPETE--RQR
|  ||.|.| ...|            | | || ...   | .| .|. ||||||. |||.   .... .|| |  ..|
lknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeeker
subfamily_ILKAP_pd Subfamily ILKAP 378-505 5.2e-08 25.4 In-house 177-290 (293) alignment 
Range on Protein: 378-505
Range on HMM: 177-290/293.0
KKARVMATIGVTRGLGDHDLKVHDsniyikpfLSSAPEVRIYDLSKYdhgsDDVLILATDGLWDVLSNEEVAEAITQFLPNCdpddPHRYTLAAQDLVMR
.. ||.  ..|.| .||   |           ..| |.|.  .|..     |  ..|| ||||.|.|..||.. |.. | .      .  ... .. . .
rdgrvlGvlevsrsiGdgrfkrlG........vistPdvkkceLten....dlfvvlaCdGLwkvfsadevvkfilkvlede....eddrkikeeekksk

ARGVLKDRGWRISND--RLGSGDDISVYVI
.   ..    |....  . ||.|...| ..
eevrfevacnrlaseavkrgssdnvtvllv
subfamily_PDP_pd Subfamily PDP 147-296 2.3e-07 23.3 In-house 28-181 (398) alignment 
Range on Protein: 147-296
Range on HMM: 28-181/398.0
WSLFDGHAGSGAAVVASRLLQHHITEQL---QDIVDI---LKNSAVLPP-TCLGEEPENTPANSRTLTRAASLRggvgapgspstppTRFFTEKKIPHEc
 ..||||.|  .|   |. | .... .|   |.....   |.... | . .   ...... ..... . ...|.             ...    ..  | 
fgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslsels.............kylqelleaeve.

LVIGALESAFKEMDLQIERERS------------SYNISGGCTALIVIcLLGKLYVANAGDSRAIIIRN
 |  ||..||...| .|  |                 .|| |. | .|    .|.|||.||.||.. ..
kvkealkkaFlklDkdistealkklkekslreallvalsGacallali.egtelhvAntGDcravlgvq
subfamily_PPM1G_pd Subfamily PPM1G 380-457 3.7e-07 22.5 In-house 357-430 (473) alignment 
Range on Protein: 380-457
Range on HMM: 357-430/473.0
ARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKydhgSDDVLILATDGLWDVLSNEEVAEAITQFLP
 ||   . . | ||||  |   .       .|  |....  | .     |. |.||.||.|.|.. .|| . ... | 
gRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlte....edeFlvlAcDGiWnvmesqevvdfvraklk
subfamily_PPTC7_pd Subfamily PPTC7 425-483 4.2e-07 22.6 In-house 163-217 (252) alignment 
Range on Protein: 425-483
Range on HMM: 163-217/252.0
DHGSDDVLILATDGLWDVLSNEEVAEAITQFLpncdPDDPHRYTLAAQDLVMRARGVLK
.  ..|...||||||.| |...|..|....        ....   .|..|...|| . .
avkkgDiivlatDGlfDNlledeileilkelk....eseksslqslakklaekarelsl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 244-314 4.9e-07 22.3 In-house 76-143 (255) alignment 
Range on Protein: 244-314
Range on HMM: 76-143/255.0
ALESAFKEMDLQIererSSYNISGGCTALIVICLLGKLYVANAGDSRAIII-RNGEIIPMSSEFTPETERQR
.|. |.||...||    | . .  |.||  |. .  | |.|| ||||...  ..|    .| .  |  |...
slkkaykeistqi....serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseesee
PPM_PTC7_SpoIIE_motif 428-505 6.6e-07 22.9 In-house 11-78 (81) alignment 
Range on Protein: 428-505
Range on HMM: 11-78/81.0
SDDVLILATDGLWDVL-------SNEEVAeaitQFLPNCdpdDPHRYTLAAQDLVMRARGvlkdrgwrisNDRLGSGDDISVYVI
 .|||.|.||||..         ..||..    ......   . ..  ..|. || ...           |.. .. |||.. |.
pgdvllLyTDGltEardsdgelfgkeell....rladra...egkslqeladklvdevle..........ngsgereDDitllvl
subfamily_ILKAP_pd Subfamily ILKAP 248-298 7.6e-07 21.6 In-house 92-144 (293) alignment 
Range on Protein: 248-298
Range on HMM: 92-144/293.0
AFKEMDLQIERE--RSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGE
.||. | .  ..  ..      |.|| .|. |   ||||| |||.|...|. |
sfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkke
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 384-454 9.6e-07 20.9 In-house 179-240 (276) alignment 
Range on Protein: 384-454
Range on HMM: 179-240/276.0
ATIGVTRGLGDHDLKVHDSNIYIKPFLSSApevriYDLSKYdhgsDDVLILATDGLWDVLSNEEVAEAITQ
  . |.| |||| .|  .  .  .|..|.      . |. .    |. ||.|.||||||.| ..  | .  
nGlavsralGdhfikelniGlisepyvsnr.....illtpf....dkflivasdGlwdvisGkdaiekvks
subfamily_KAPP-like_pd Subfamily KAPP-like 384-454 9.7e-07 21.1 In-house 169-230 (266) alignment 
Range on Protein: 384-454
Range on HMM: 169-230/266.0
ATIGVTRGLGDHDLKVHDSNIYIKPFLSSApevriYDLSKYdhgsDDVLILATDGLWDVLSNEEVAEAITQ
  . |.| |||| .|  .  .  .|..|.      . |. .    |. ||.|.||||||.| ..  | .  
nGlavsralGdhfikelniGlisepyvsnr.....illtpf....dkflivasdGlwdvisGkdaiekvks
subfamily_PPM1K_pd Subfamily PPM1K 379-454 1.1e-06 20.9 In-house 163-227 (263) alignment 
Range on Protein: 379-454
Range on HMM: 163-227/263.0
KARVMATIGVTRGLGDHDLKVHDsnIYikpflsSAPEVRIYdlsKYDHGSDDVLILATDGLWDVLSNEEVAEAITQ
| .| . . .|| ||| ||| .   .       . || .     | ||..|  |.| |||. .|....|... ...
kplvngrlamtrslGdldlkryG..vi......atPetksl...kvdhaadsflvlitdgisfvvnsqelcdlvrl
subfamily_PP2D1_pd Subfamily PP2D1 276-314 3e-06 19.2 In-house 185-225 (492) alignment 
Range on Protein: 276-314
Range on HMM: 185-225/492.0
CLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETE--RQR
  || ||.||||. .|...|.|. | .  | ||. .  |.|
eelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtR
PP2C_2 Protein phosphatase 2C 149-463 3.2e-06 19.6 Pfam-A 29-202 (212) alignment 
Range on Protein: 149-463
Range on HMM: 29-202/212.0
LFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAvlpptclgeepENTPANsRTLTRAA---Slrggvgapgspstpptrfftekkipheclvigal
  ||.     . ...||. . ..|.|.....  . ..           |.. .. ......    .                                  
VADGaGsakrSdkGarlaveaagealeklleeeseqe...........eeallr.qieneilasvk..................................

esafkemDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRA-IIIRNGEIIPMSSEFTPETERQrlqyLAFMQPHLLGNEFthlefprrvqrkel
       . | . .. .   . ..| |....  |...... ||... .. |.||. ..... . | ...    . |....  . |.              
.......lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane....ttfltsedaeeel..............

gkkmlyrdfnmtgwayktiededlkfpliygegkkarvmatigvtrglgdhdlkvhdsniyikpflssapevriyDLSKYDHGSDDVLILATDGLWDVLS
                                                                           .... .  . | |.| |||..| |.
...........................................................................rirrlklepgdalllmTDGvsdslr

NEE-VAEAITQFLPNCDPDD
.|| ..| ....| . ....
keepfrellaelletleeeg
PP2C_2 Protein phosphatase 2C 149-463 3.2e-06 19.6 In-house 29-202 (212) alignment 
Range on Protein: 149-463
Range on HMM: 29-202/212.0
LFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAvlpptclgeepENTPANsRTLTRAA---Slrggvgapgspstpptrfftekkipheclvigal
  ||.     . ...||. . ..|.|.....  . ..           |.. .. ......    .                                  
VADGaGsakrSdkGarlaveaagealeklleeeseqe...........eeallr.qieneilasvk..................................

esafkemDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRA-IIIRNGEIIPMSSEFTPETERQrlqyLAFMQPHLLGNEFthlefprrvqrkel
       . | . .. .   . ..| |....  |...... ||... .. |.||. ..... . | ...    . |....  . |.              
.......lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane....ttfltsedaeeel..............

gkkmlyrdfnmtgwayktiededlkfpliygegkkarvmatigvtrglgdhdlkvhdsniyikpflssapevriyDLSKYDHGSDDVLILATDGLWDVLS
                                                                           .... .  . | |.| |||..| |.
...........................................................................rirrlklepgdalllmTDGvsdslr

NEE-VAEAITQFLPNCDPDD
.|| ..| ....| . ....
keepfrellaelletleeeg
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 240-316 4.8e-06 19.3 In-house 63-142 (292) alignment 
Range on Protein: 240-316
Range on HMM: 63-142/292.0
LVIGALESAFKEMDLQIErerssYNISGGCTALIVICLLG-KLYVANAGDSRAIIIR-----NGEIIPMSSEFTPE--TERQRLQ
|. . |. | |  .| |.      . |.. ..   .   . .|..|| |||||.. |     . |.||.| .  ||   ||.|..
lllrildiaakldkltid.....aresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderaril
subfamily_PPTC7_pd Subfamily PPTC7 263-306 5.1e-06 19.1 In-house 83-128 (252) alignment 
Range on Protein: 263-306
Range on HMM: 83-128/252.0
YNISGGCTALIVICLLG--KLYVANAGDSRAIIIRNGEIIPMSSEF
 .. |..||.||.      ||..|| |||  ...|.|...  |.| 
vpvlGssTacivvldksdkklesanlGDSgflvvRkgkvvfrskeq
subfamily_KAPP-like_pd Subfamily KAPP-like 135-176 6.6e-06 18.3 In-house 25-66 (266) alignment 
Range on Protein: 135-176
Range on HMM: 25-66/266.0
ENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQD
|.  |.      ...|||||| |||. |..|... . ..|. 
ekklsncsnialfavfdGhaGkGaadaakklfpkelekllks