Gene PPM1K in Homo sapiens

Synonym: BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07, PPM1K

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1K
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP184_AA protein Get Run
HsapP184_AA_82-350 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1K_pd Subfamily PPM1K 92-351 2.1e-146 479.0 In-house 3-263 (263) alignment 
Range on Protein: 92-351
Range on HMM: 3-263/263.0
LENVGCASQIGKRKENEDRFDFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARLS-ADATLLTSGTTA
||.||..|.||||.|||||.....|..|.||.||.|||.|.|||||.|...||....||.|||.||..|. ||.|.||........| |.|.||.|||||
lesvGkdsliGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGtta

TVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADD
||.|||||.|||.||.|||||||||.||..|||.||.||...||||||..||.|.|||||.|.||||||||||.||||||..||||.||||..|..||.|
tvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaad

SFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWGK
|||||.||||.|.|||||.||.|..||||.|||||.||||.|||.|||.||||||.|||||
sflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvplgawgk
0034914 PP2C-like 83-350 3.4e-73 238.9 In-house 11-294 (295) alignment 
Range on Protein: 83-350
Range on HMM: 11-294/295.0
YGKPIPKISLENVGCASQIGKRKENEDRFDFAQ----LTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMD--------LLPKEKNLETLLTLAFLEIDKA
. . .  . | .||.|| .|.||.|||.. .      |....|.|.|.||||| |||.... .. . ...        | . . ..|. |. |||..|..
llllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadee

FSSHARLsaDATLLTSGTTATVALLRDGIeLVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWnslgqPHVNGRLAMTRSIGDLDLK
. ..|.|  .  |..|||||.|||.|..  |.|| ||||||.|.|.|... ||.||.| . .|.|||...||.| .     ..||| ||.||..|| |||
llelall..rpelagsGtTavvalirgnk.lyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.....grvngvlavtRalGdfdlk

--------TSGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQ----CHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWG
          .|.|||... ..|.. || ||.| .||.  .....||.|.|..    ..|..|||......|...|  || |.||| .. .|
lllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlnglg
PP2Cc_SM00332 95-344 6e-64 209.1 In-house 12-274 (274) alignment 
Range on Protein: 95-344
Range on HMM: 12-274/274.0
VGCASQIGKRKENEDRFDFAQL---TDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKN-----LETLLTLAFLEIDKAFSSHARLSADATlLTS
 |..|. |.||..||..         ...|.|.|.|||||...|.|.  .. ... . | |.|.      | .|  |||..|...  ... . .    .|
ygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.als

GTTATVALLRDGIeLVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNslgqpHVNGRLAMTRSIGDLDLKT------SGVIAEPET
|.||.||||...  |.||.||||||.|||.||   |. ||.||..||..|||| ||.|...      ||| ||..|..|| .||.       ...|||..
Gstavvallkked.lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg.....rvngglavsrafGdhflkknkklkepyitaepdv

KRIKLhHADDSFLVLTTDGINFMVNSQEICDFVNQCH------DPNEAAHAVTEQAIQY-GTEDNSTAVVV
| ..|   .| ||.| .||.  ....||..|.|...       || |||  ..|.||.. | ||| |.|||
kvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 115-338 3.5e-59 193.4 Pfam-A 29-254 (255) alignment 
Range on Protein: 115-338
Range on HMM: 29-254/255.0
QLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKN--LETLLTLAFLE-IDKAFSSHARLsaDaTLLTSGTTATVALLRDGIeLVVASVGDSRA
.  ..| .|||.|||||  ||.....|.|...     ...   .| .|  .||. .|. . |..    .   ..||.||.|||.|.   | || ||||||
sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskan..t.epsksGstavvalirgkk.lyvAnvGDSra

ILCRKGKPM-KLTIDHTPERKDEKERIKKCGGFVAWnslgQPHVNGRLAMTRSIGDLDLKT---SGVIAEPETKRIKLHHAdDSFLVLTTDGINFMVNSQ
.||||...  .|| ||.|...||.|||.. ||.| .    .  ||| ||..|..||..||      |.|||... .||    |.||.| .||.  ....|
vLcrkdnakkeltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdq

EICDFVNQCHD----PNEAAHAVTEQAIQYGTEDN
|..|.|... .    |.||| .. ..||..|.|||
eavdlvrselskkkspmeaaeelvdeaiargsedn
PP2C Protein phosphatase 2C 115-338 3.5e-59 193.4 In-house 29-254 (255) alignment 
Range on Protein: 115-338
Range on HMM: 29-254/255.0
QLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKN--LETLLTLAFLE-IDKAFSSHARLsaDaTLLTSGTTATVALLRDGIeLVVASVGDSRA
.  ..| .|||.|||||  ||.....|.|...     ...   .| .|  .||. .|. . |..    .   ..||.||.|||.|.   | || ||||||
sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskan..t.epsksGstavvalirgkk.lyvAnvGDSra

ILCRKGKPM-KLTIDHTPERKDEKERIKKCGGFVAWnslgQPHVNGRLAMTRSIGDLDLKT---SGVIAEPETKRIKLHHAdDSFLVLTTDGINFMVNSQ
.||||...  .|| ||.|...||.|||.. ||.| .    .  ||| ||..|..||..||      |.|||... .||    |.||.| .||.  ....|
vLcrkdnakkeltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdq

EICDFVNQCHD----PNEAAHAVTEQAIQYGTEDN
|..|.|... .    |.||| .. ..||..|.|||
eavdlvrselskkkspmeaaeelvdeaiargsedn
0049733 PP2C-like 94-346 3e-58 189.8 In-house 4-233 (235) alignment 
Range on Protein: 94-346
Range on HMM: 4-233/235.0
NVGCASQIGK-RKENEDRFDFaqltdEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK--EKNLETLLTLAFLEIDKAFSSHARLSAdaTLLTSGTTA
.||.|| ||. ||.|||.. .     ..|.|||.||||| ||....  .. .....|| .  . .||..|. |||....|. ..|. |    | ..||||
svgaasdigrvrkvneDavlv.....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp..elagmgtTa

TVALLRDGiELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVawnslgqpHVNGRLAMTRSIGDLDLKtsgviaePETKRIKLHHADd
.||||..|  |.||.||||||.|.|.|| . || ||.| . .|..||...||.|        .|.||||.||..|||.||       |.. ...|.. | 
vvalldgg.klyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav........rvpgrlaltralGdlllk.......pdvtvlelepgd.

sFLVLTTDGINFMVNSQEICDFVNQcHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF
 ||.|..||.  .....||.|.... .|..|||....|.|...|. || |.||| .
.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
PPM_PTC7 104-338 6e-58 189.3 In-house 12-258 (259) alignment 
Range on Protein: 104-338
Range on HMM: 12-258/259.0
RKENEDRFDFAQ------LTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKN--LETLLTLAFLE--IDKAFSSHARLsaDaTLLTSGTTATVA
||..||.  ...        |.| .|||.|||||  ||.....|.|...     .|.   ||  |. .||.  .|. . |..    .   .|||.||.||
rksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelkssean..t.epstsGstAvva

LLRDGIeLVVASVGDSRAILCRKGKPM-KLTIDHTPERKDEKERIKKCGGFVAWNslGQPHVNGRLAMTRSIGDLDLKT-----SGVIAEPETKRIKLHH
|...   | || ||||||.|||.|..  .|| ||.|...||.|||.. ||.| .   |.  ||| ||..|..||..||        |.|||... .|.  
litgsk.lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv..gngrvngvlavsRafGdfelkpketeeqlvsaePdisstkide

AdDSFLVLTTDGINFMVNSQEICDFVNQCHD---PNEAAHAVTEQAIQYGTEDN
  | ||.| .||.  .|..||..|.|... .   |.||| .. . ||..|.|||
e.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedn
subfamily_PPM1A_pd Subfamily PPM1A 95-346 1.9e-56 184.5 In-house 14-280 (282) alignment 
Range on Protein: 95-346
Range on HMM: 14-280/282.0
VGCASQIGKRKENEDRFDFAQLTDE---VLYFAVYDGHGGPAAADFCHTHMEKCIMD---------LLPKEKNLETLLTLAFLEIDKAFSSHARLSADAt
.| .|. | |.|.||... ..   .     .|||.|||.|  .|.....|. . |..            ......  |  .||..|.| ... . .  | 
ygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlkta.

lLTSGTTATVALLRdGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAwnslgQPHVNGRLAMTRSIGDLDLKT--------SGV
 . ||.||...|..   .|..| .|||||.|||.|| . || || |.|..||.||.. ||.|         ||| ||..|..|| ..|.          |
.dksGsTavtvlvs.ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.....vsRvnGaLAvsRalGDyeykeeeekkaeeqlv

IAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQC----HDPNEAAHAVTEQAIQYGTEDNSTAVVVPF
.||||.. |. .. || ||||. |||  .....|....|..     ....| |.|. ..|.. |..|| ...|| |
saepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
subfamily_PPM1E_pd Subfamily PPM1E 105-344 4.4e-53 173.1 In-house 16-260 (265) alignment 
Range on Protein: 105-344
Range on HMM: 16-260/265.0
KENEDRF----DFAQLT-----DEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARlsadATLLTSGTTATVALL
.  |||.    |. .|      .|  .|||.|||||  ||..  .|. . ...    ... .. |  || ..|..| ..|        |.||.|| |.|.
rkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkae....reklksGstavvvli

RDGIeLVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNslGQPHVNGRLAMTRSIGDLDLKTSgVIAEPETKRIKLHHADDsFLVL
.    | || .|||.|.|.|||. ..|.  | |||.|||.||.. ||.| .   |.  ||| |...|.||| .||   |..|... ...|..... .|.|
ekdq.lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi..gawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgsee.ylil

TTDGINFMVNSQEICD----FVNQCH-DPNEAAHAVTEQAIQYGTEDNSTAVVV
..||.  .|| .|...    |... . | .|.|. . |.|.. | .|| |.|||
acDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 94-346 1.7e-46 151.6 In-house 7-253 (255) alignment 
Range on Protein: 94-346
Range on HMM: 7-253/255.0
NVGCASQIGKRKENEDRFD----FAQLTDEVlYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKN-LETLLTLAFLEIDKAFssharlsA--DatlLTS
.|| .  ||.|   ||..     | . .||  |.|..||||| |||.|.  ...| . .||  ..   .  |. |. ||.  .       .         
kvgfsdmiGrrptmedelviyGsfrdksded.yyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi.......serp...kfi

GTTATVALLRDGiELVVASVGDSRAILC-RKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNsLGQPHVNGRLAMTRSIGDLDLKtSGVIAEPETKRIKL
||||...|. .    ..| |||||..|| ..|   .|..|| |  ..|..||.. ||.|  .      ||| ||..|..||  |.   |...|. ..   
Gttaasvliied.kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst.vvtsrvnGtlavsralGdsfle.PfvvpdPdlsqsle

HHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF
 . .| ||.|. |||  ..  .| .. | .  ||..||  . ..| . |..|| . .|. .
iskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 94-346 2.9e-45 147.6 In-house 6-266 (269) alignment 
Range on Protein: 94-346
Range on HMM: 6-266/269.0
NVGCASQIGKRKENEDRFDFAQL-TDE--VLYFAVYDGHGGPAAADFCHTHMEKCIMDLL-----PKEKNL----ETLLTLAFLEIDKAFSSHARLSADa
.|   |  |.|.. ||||....  ...    .|||.|||||  ||.|..  . | |.. |      ||...    ..|||   | .|. .  .|. . | 
qvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed.

tllTSGTTATVALLRDgIELVVASVGDSRAILCR-KGKPMKLTIDHTPERKDEKERIKKCGGFVAWNslGQPHVNGRLAMTRSIGDLDLKTSG-VIAEPE
   ..|||| .||...  .|.|| ||||| .|.  .|| . |. || |..  |. |||| |||.|..  |   |.| ||..|..||  ||    |||.|.
...iaGttalialvqe.sdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafr..GvwrvaGvlatsralGdyplkdknlviadpd

TKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVN-QCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF
   ..|.. .  ||.|..||.      .| . |.  . ..|.  |.... .. . |. || | .|| .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
subfamily_PPM1G2_pd Subfamily PPM1G2 95-337 3.8e-43 140.5 In-house 21-267 (287) alignment 
Range on Protein: 95-337
Range on HMM: 21-267/287.0
VGCASQIGKRKENEDRFDF----AQ--LTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLL-PKEKNLETLLTLAFLEIDKAFSSHARLSADatllTSG
|| ..  | | . ||         .   .... .|||.||||| ..| .. ... | |.     || .||..|  ||||.|. . .. .|. .    ..|
vgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkde....saG

TTATVALLRDGIeLVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNslgqpHVNGRLAMTRSIGDLDLKTSG--------VIAEPE
.||.|.|...   |.|| .|||||.|. ||.  .|..|| |....||.||.. ||||. |      ||| ||. |..||   |..         | |.|.
stavvvlikeek.lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.....rvngnLalsralgDfefkknvkkkpeeqivtavPD

TKRIKLHhADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTED
    ||.  || ||||  |||  .....|..|.|..    . . ....|. .. .   
vlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclap
subfamily_ILKAP_pd Subfamily ILKAP 117-330 1.8e-42 138.5 In-house 40-256 (293) alignment 
Range on Protein: 117-330
Range on HMM: 40-256/293.0
TDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKE------KNLETLLTLAFLEIDKAFSSHARlsADATLLTSGTTATVALLRDGIeLVVASVGDSR
   | |.||.|||.|. |..|.  ...| |.. |||.      |..   |. .| . |. | . |.  ..      |.|||| |  | . | || .|||.
vsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklas..kakPvWkdGstatvvlvldnv.lyvanlGdsk

AILCRKGK------PMKLTIDHTPERKDEKERIKKCGGFVAwnslgQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHAdDSFLVLTTDGINFMV
|.|.|| .       ..|| |||| ...|..||.|.||.|      .  |.| | ..|||||   |..|||. |..|...| .  | |.||. ||.   .
avlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.....dgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLten.dlfvvlaCdGLwkvf

NSQEICDFVNQCHDPNEAAHAVTEQA
. .|. .|.... . .|  . . |. 
sadevvkfilkvledeeddrkikeee
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 102-280 1.6e-36 119.3 In-house 2-196 (292) alignment 
Range on Protein: 102-280
Range on HMM: 2-196/292.0
GKRKENEDRFDFAQLTDEVLY-FAVYDGHG--GPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFsshARLSADATlLTSGTTATVALLRDG
. .|||.|||   . .. . .  ||.||||  | . |..   ..|. ...| .. ..|   | |  |.|   .    .| .||  . ..|... |  ||.
ankkenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakl...dkltidar.esattavvcarvrdd

IELVVASVGDSRAILCR-----KGKPMKLTIDHTPERKDEKERIKKCGGFVA------WNSLGQPHV------NGRLAMTRSIGDLDLKTSGVIAEPET
 .|..| ||||||.| |     . ... |. || ||  ||..||.. ||.|       |   | . |      .| ||..|..||. |. .||.|||| 
ralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
subfamily_PPM1G_pd Subfamily PPM1G 185-318 8.3e-33 107.1 In-house 295-430 (473) alignment 
Range on Protein: 185-318
Range on HMM: 295-430/473.0
TSGTTATVALLRDGiELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlgqpHVNGRLAMTRSIGD--------LDLKTSGVIA
 |||||.||||..  .|.|| .||||..|.|.|| . | .|| || . |.|||.| || |  .      ||| | . | .||        |.||   . |
dsGttAvvaLlkek.klivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg....RvnGGLnlsRAlGDhaYkkneeLplkeqmisA

EPETKRIKLHHaDDSFLVLTTDGINFMVNSQEICDFVNQCHD
 |. |  .| . .| |||| .|||  ...|||. |||..   
lPDikvltlte.edeFlvlAcDGiWnvmesqevvdfvraklk
PPM_PTC7_SpoIIE 105-338 6.3e-30 97.7 In-house 13-229 (230) alignment 
Range on Protein: 105-338
Range on HMM: 13-229/230.0
KENEDRFDFAQ------LTDEVLYFAVYDGHGGPAaaDFCHTHMEKCIMDLLPKEKN-LETLLTLAFLEIDKAFSSHarlsadatLLTSGTTATVALLRD
|..||.  ...        . .|.....|||||.|   ...... ...  |  .. . .| .|. ..|...... .           .||.||.|||.. 
ksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede........psssgaTavvalidp

GI-ELVVASVGDSRAILCRK-GKpmkltidhtperkdEKERIkKCGGFVAwNSLGQPHVNGRLAMTRSIGDLDLK-TSGVI-AEPEtKRIKLHHADDSFL
   .| ||..|||...|.|. |.              |.||| . ||..   ...   |.| ||.....||| |. | ||. |||.    ..   .| ||
stgklyvanaGdsppllvrddgg..............ereri.vagglps.lGilpgrvfgvlavslapGdllllytDGvveaepd.tsdgelfgkdefl

VLTTDGINFMVNSQEICDFVNQCHDPNeAAHAVTEQAIQYGTEDN
.| .||.  ....||..|.| .. ... || .  | .| ... ..
ilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv
subfamily_PPM1D_pd Subfamily PPM1D 98-323 5.4e-29 94.3 In-house 7-271 (309) alignment 
Range on Protein: 98-323
Range on HMM: 7-271/309.0
ASQIGKRKENEDRFDFAQLT------DEVLYFAVYDGHGGPAAADFCHTHMEKCIMD---LLP-KEKNLETLLTLAFLEIDKAFSSHAR---LSADATLL
... | ||  ||..  .          || ..||.|||||  || | . |. . | .   .|  ..... . .  |||.. .|   . .     .. .| 
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksglls

TSGTTATVALLRDgIELVVASVGDSRAILCRKGK------PMKLTIDHTPERKDEKERIKKCGGFVA---------WNSLGQPhVNGR--------LAMT
|.||||.| ..|.  .| || ||||...|  | .      . .|| || ||  .|||||...|| ||         |.   .   ||.        ||..
taGttasvviirr.eklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprle.hngptvideiPFLava

RSIGDL---DLKTSGVI--AEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAA
||.|||   . |.   .   ||..|  .|. ... |..|..||.  ......  ..|.. .  .|  
RslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelk
subfamily_PP2D1_pd Subfamily PP2D1 189-316 2.5e-22 72.2 In-house 179-305 (492) alignment 
Range on Protein: 189-316
Range on HMM: 179-305/492.0
TATVALLRDGIeLVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQPHVNGRLAMTRS---IGDLDLKTSgVIAEPETKRIKL
.  | |   |. | .| .|. .|.|||.|| ..|| .|||. | |..|..| |. |  .   .  ||| |  ||    .||..|| | || ||.|. .||
gsevhleelgv.lyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkse.knglvnGildttRGLGnyGdpkLkks.vipePkttsvkl

HHAdDSFLVLTTDGINFMVNSQEICDFVNQC
 .| . |||| . |.  ... .|.   |.| 
dea.aqflvlAsnGlWevlseeevlsLvkqt
subfamily_KAPP-like_pd Subfamily KAPP-like 119-344 9.3e-22 70.3 In-house 33-264 (266) alignment 
Range on Protein: 119-344
Range on HMM: 33-264/266.0
EVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLtlAFLEIDKAFSSHARlSADATL---LTSGTTATVALL-RDGIE--LVVASVGDSRAI
..  |||.||| |  |||  .  ..| . .|| . |. .        .  | .    . . || |      |.|||.||. .||    | || |||| |.
nialfavfdGhaGkGaadaakklfpkelekllkstkqddGGd..niydqskllenafk.evdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaf

LCRKGKPMKLTIDHTPERKDEKERIKKCGGFVawnSLGQPHVNGrLAMTRSIGDLDLKT--SGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEIC
|.|  . ..|. ||  . ..|| |||. |  .   | .|  .|| ||..|..||  .|    |.|.||      |    |.||....||.  ... ..  
lsrGneslelskdhkakdpeekqrikddGitl...sdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdai

DFVNQCHDPNEAA----HAVTEQAIQYG-TEDNSTAVVV
. |.  .| ....     .. | |||   . || . .||
ekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_PHLPP_pd Subfamily PHLPP 113-345 1.1e-20 66.5 In-house 21-244 (246) alignment 
Range on Protein: 113-345
Range on HMM: 21-244/246.0
FAQLTDEVLYfAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSS-HARLSAdATLLTSGTTATVALLRDgIELVVASVGDSRA
 |.|..| ||  ..||.     .    . |.. ... . |.|| |  .   .| . .   .   .| . | ||.     .|  ..    | |||||   |
vaalsvealy.GlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgs.aallilirhdkvdPaks.fsLevAsvGtlqa

ILCRKGKPMKLTIDHTPErKDEKERIKKCGGFVAWNSlgqpHVNGRLAMTRSIGDLDLKTSgVIAEPETKRIKLHHaDDSFLVLTTDGINFMVNSQEICD
.|.|.||...|.  .. | ||| .|||.  ...  ..    ..|| .. || .| . |  . |. .|. . ..| . .| .|..  . .  ... .|. .
vliRngkklrlsksyvie.kdelkrikeakaiitedn....kingviestrllGytflfPv.vlPkphvrevlLte.qdellivGnkalWevlsideave

FVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVP
 | . .||  ||  ....|  ||..|.....|| 
avrkeedplvaAkklvdlaqsygaadsvsvlvvr
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 119-344 1.9e-18 59.4 In-house 32-274 (276) alignment 
Range on Protein: 119-344
Range on HMM: 32-274/276.0
EVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK--------------EKNLETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRDGIELVVA
..  |||.||| |  |||  .  . | .. ||                  . . ||  .| |.|. .. .    | |||    .       ..   | ||
nialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqva

SVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVawnSLGQPHVNGrLAMTRSIGDLDLKT--SGVIAEPETKRIKLHHADDSFLVLTTDGINF
 |||| |.|.|  . ..|. ||  .  .||.|||. |  .   | .|  .|| ||..|..||  .|    |.|.||      |    |.||....||.  
nvGdssaflsrGneslelskdhkatdpeekqrikddGitl...sdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwd

MVNSQEICDFVNQCHDPNEAA----HAVTEQAIQYG-TEDNSTAVVV
... ..  . |.  .| ....     .. | |||   . || . .||
visGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
PP2C_SIG_SM00331 101-345 1.3e-17 57.1 In-house 9-216 (217) alignment 
Range on Protein: 101-345
Range on HMM: 9-216/217.0
IGKRKEN--EDRFDFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAfssharlsadATLLTSGTTATVALL-RD
. .  ..  .| .|. .| .. | ..| ||.|. .||  .   . . .. || ....|...|  .   |..           ..   ...|...||.   
yyeeatqvsGDyydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee..........keekgmfaTlllalydfs

GIELVVASVGDSRAILCRKGKPMKLTIDhtperkdekerikkcggfvawnslgqphvngrlamtrsigdLDLKTSGVIAEPE--TKRIKLHHadDSFLVL
. .| .|..|||| .| |.||  . . |                                            .  |.. |..  .. ..|.   ...|.|
sgklsyanaGdsrpyllrdgklveilkd.........................................vegaplGlepevsvdirelelek..gdllll

TTDGINFMVNSQ---------EICDFVnqCHDPNEAAH----AVTEQAIQYGTEDNSTAVVVP
 |||.  .....          ..|.|  .. . | |.     . |.| ....||. | ||| 
ytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 169-344 2.2e-14 45.4 In-house 117-313 (317) alignment 
Range on Protein: 169-344
Range on HMM: 117-313/317.0
KAFSSHARLSADATLLTSGTTATVALLRDGIELVVASVGD--SRAILCRKGKPMK--------LTIDHTPERKDEKERIKKCGGFVAWN-------SLGQ
| .   .|  ...  |  ||||.||.. | . .|||  ||  .  .| .. .. .        |.. || . |.|..|...  .  |          | .
kgyvcisrddvptrPldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylailde

PHVNGRLAMTRSIGDLDLKTSGVIAEPETkRIKLHHADDSFLVL-TTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYG----TEDNSTAVVV
   . .| .|.|.|   ||. ||||.||  | .   .|. | |.  .|||   .. ... | | ..    ||.. . . | .|     . |..||||.
alaayelqltkslGhkllkraGviadPev.rsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvl
subfamily_TAB1_pd Subfamily TAB1 184-271 1.7e-13 43.1 In-house 127-214 (333) alignment 
Range on Protein: 184-271
Range on HMM: 127-214/333.0
LTSGTTATVALLRDGiELVVASVGDSRAILCR---KGKPMKLTIDHTPERKDEKERIKKCGgfVAWNSLGQPHVNGRLAMTRSIGDLDLKT
.. |||| |||.    .| || ||||||.|..   . |  .|  ||| . .|| .|.|. |  .  . . . .. |    ||||||. .|.
isgGttAvvalifnn.kLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvkk
subfamily_PPM1G_pd Subfamily PPM1G 94-176 4.6e-13 42.0 In-house 20-104 (473) alignment 
Range on Protein: 94-176
Range on HMM: 20-104/473.0
NVGCASQIGKRKENEDRFDF-AQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLL-PKEKNLETLLTLAFLEIDKAFSSHAR
..|...  | |...||      .|....  ||||||||| . | .. ... ... .    || ..|. |. |||..|.   ... 
sygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkaees
PP2C_2 Protein phosphatase 2C 98-323 4.4e-12 38.7 Pfam-A 3-201 (212) alignment 
Range on Protein: 98-323
Range on HMM: 3-201/212.0
ASQIGKRKENEDRFDFAQLTDEVLYfAVYDGHGGPAAAD-----FCHtHMEKCIMDLLPKEKNL--ETLLTLAFLEIDKAF-SSHARLSADATLLTSGTT
.| . |.| ..|.... .  |  |  || ||.|  . .|     ...  . ... .|| .|.    |.||  .  ||...   .  . .....|   .||
rshrrkgkpcqDalaireasdgwll.aVADGaGsakrSdkGarlave.aagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatT

ATVALLRDgIELVVASVGDSRA-ILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWnslgqphvngrlamtrsigdldlktsgviaepetKRIKLHHA
 ..|....  |.|....||... .  | |.   |..... | . |  ....   .  .                                  ....|   
lllavitp.geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..................................rirrlkle

DDSFLVLTTDGIN-FMVNSQEICDFVNQCHDPNEAA
. . |.|.|||.   ......  ..... ..  |..
pgdalllmTDGvsdslrkeepfrellaelletleee
PP2C_2 Protein phosphatase 2C 98-323 4.4e-12 38.7 In-house 3-201 (212) alignment 
Range on Protein: 98-323
Range on HMM: 3-201/212.0
ASQIGKRKENEDRFDFAQLTDEVLYfAVYDGHGGPAAAD-----FCHtHMEKCIMDLLPKEKNL--ETLLTLAFLEIDKAF-SSHARLSADATLLTSGTT
.| . |.| ..|.... .  |  |  || ||.|  . .|     ...  . ... .|| .|.    |.||  .  ||...   .  . .....|   .||
rshrrkgkpcqDalaireasdgwll.aVADGaGsakrSdkGarlave.aagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatT

ATVALLRDgIELVVASVGDSRA-ILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWnslgqphvngrlamtrsigdldlktsgviaepetKRIKLHHA
 ..|....  |.|....||... .  | |.   |..... | . |  ....   .  .                                  ....|   
lllavitp.geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..................................rirrlkle

DDSFLVLTTDGIN-FMVNSQEICDFVNQCHDPNEAA
. . |.|.|||.   ......  ..... ..  |..
pgdalllmTDGvsdslrkeepfrellaelletleee
subfamily_PDP_pd Subfamily PDP 155-240 1.6e-11 37.0 In-house 114-210 (398) alignment 
Range on Protein: 155-240
Range on HMM: 114-210/398.0
NLETLLTLAFLEIDKAFSSHARLS------AD-ATLLTSGTTATVALLrDGIELVVASVGDSRAILCRKG-----KPMKLTIDHTPERKDEKERIKKC
...  |. |||..|| .|. |  .      .. ..  .||..|..||. .| || ||..||.||.|...      . .||..|.| . ..| ||||| 
kvkealkkaFlklDkdistealkklkekslreallvalsGacallali.egtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke
Subfamily Dicty-PPM1L-like 250-346 1.1e-10 33.8 In-house 197-303 (305) alignment 
Range on Protein: 250-346
Range on HMM: 197-303/305.0
GQPHVNGRLAMTRSIGDLDLKTsGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQC-----------HDPNEAAHAVTEQAIQYGTEDN
|.  ||. |   ||.|| .||   || ... .   . .|.|.||||.|||.  ... |.. ..|..             |.||  . . |.|.. | .||
gellvnrllkksrskGdknlke.lviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDn

STAVVVPF
 | |....
itlviikl
subfamily_PPM1H_pd Subfamily PPM1H 160-240 3.7e-10 32.1 In-house 140-213 (404) alignment 
Range on Protein: 160-240
Range on HMM: 140-213/404.0
LTLAFLEIDKAFSSHArlsaDATLLTSGTTATVALLRDGiELVVASVGDSRAILCRKGKPMKLTIDHTPERkdEKERIKKC
|  ||||.|.  .       .|  .. | || |||. .|  | ||  |||||||.||.. ..|  |.|||   |..|... 
lesaflemDeqiarer....eayrikGGCtalvalvllg.klYvanaGDsRailvrkdeiiplsadftPet..eRqRlqel
PPM_PTC7_motif 294-338 7.7e-09 28.9 In-house 1-50 (51) alignment 
Range on Protein: 294-338
Range on HMM: 1-50/51.0
VLTTDGINFMVNSQEICDFVNQCHD-----PNEAAHAVTEQAIQYGTEDN
.| .||.  ....||..|.|... .     |.|||  . ..|...|.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 286-336 2.4e-07 23.6 In-house 243-291 (292) alignment 
Range on Protein: 286-336
Range on HMM: 243-291/292.0
HHADDSFLVLTTDGINFMVNSQEICDFVNQchDPNEAAHAVTEQAIQYGTE
 . || ||||..||.  .. ..|.  ....   .. |....||.|..||. 
ldsddaflvlasdGvldvllnaevvlllak..sqeaadkvitelaleygls
subfamily_PDP_pd Subfamily PDP 274-330 2.1e-06 20.1 In-house 270-325 (398) alignment 
Range on Protein: 274-330
Range on HMM: 270-325/398.0
VIAEPETKRIKLHHaDDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQA
..||||    ||.. .| |||| |||.  .....|. . |..  . ..... |. . 
ltaePevtshklre.ndkFLvlatDGLwdllsneevvslVgehlakkkekepvkvee