Gene PPM1L in Homo sapiens

Synonym: PP2C-epsilon, PP2CE, PPM1-LIKE, PPM1L

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1L
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP185_AA protein Get Run
HsapP185_AA_84-353 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1L_pd Subfamily PPM1L 87-354 1.7e-152 499.2 In-house 1-269 (269) alignment
Range on Protein: 87-354
Range on HMM: 1-269/269.0
EFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSV-LSYQTILEQQILSIDREMLEKLT
|.|...|||||..|||..||||||. .|..|||..|.|..|||||||.|||..|..|..|.|..|.....||||.. ......|...|||.|...|||..
eekkqqvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekak

VSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDIL
...|.||||.||||....||.|||||||||||.||.|.|||||.||||.|.|||||||.|||||.|.|.|||.|.||.||.|||||||. |.||.|||||
raediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdil

TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNS
|||||...|||.|||||||||.||||||||||||||.||.|||||.||.||.||..|||||.|||..|.
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklknd

0034914 PP2C-like 85-353 1e-76 250.5 In-house 15-292 (295) alignment
Range on Protein: 85-353
Range on HMM: 15-292/295.0
TWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLAN-KTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEK
...  ...|.|.|.||||...||.. |...| .  .. ..||.|||||| .|||.....|.|.|...|. .    ..|  .....|.. .|..|.|.||.
sslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

LTV--SYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngsWRVQGILAMSRSLGDYPLKNL------
.    ...  |||...||. .. |.|||||||| ||. ..| ...|..||||..  ||.||..|||..|.   .|| |.||..|.|||..||.|      
allrpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllsllll

-NVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKER---LDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN
  .|.. ||. ...|.  . .|..|||||||| .||||.|......    ....  |. .| ... ||. |||||.||....
eplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng

subfamily_PPM1A_pd Subfamily PPM1A 89-352 4.2e-69 226.0 In-house 10-281 (282) alignment
Range on Protein: 89-352
Range on HMM: 10-281/282.0
KNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQH--LQDyEKDKENSVLSYQTILEQQILSIDREMLEKLTV
..  ..| | ||.| .|||...| ..|.. .. | | .||||.|...|.|||. |.|.. ..  |.. .. ....  ...  |.|..|..| .. |. | 
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.aaleasekdevkealrqgfLaldeairelstd

SY--DEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISfngSWRVQGILAMSRSLGDYPLKN-------LNV
.   |..|.|.. .|.|.| | .||.||||.||| ..|.|. |..||||.. ||.|||. |||..      ||.| ||.||.|||| .|.          
lktadksGsTavtvlvsekhliianlGDsRavlc.rngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeql

VIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERL---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
|...|.. ... .. .  |..||.||.||  |.||.| ....||   ||..  ||..| ... .|  ||..|.|| | 
vsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

PP2Cc_SM00332 96-349 1.2e-68 224.5 In-house 15-274 (274) alignment
Range on Protein: 96-349
Range on HMM: 15-274/274.0
YSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensVLSYQTILEQQILSIDREMLEKLTVSYD---EAG
 | ||.|. |||.. | .|| ...  ..||.||||||. .|..|...||||||..|.  ....     . . .|.. .||.| |.||.  .. .    .|
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeileeeqskelenalsG

TTCLIALLSDKDLTVANVGDSRGVLCDKDGnAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLK-----NLNVVIPDPDILTF
.|...|||...|| |||||||| ||| ..  |..|| |||| . .||||||.|||.....   ||.| ||.||..||. ||     .  .....||. . 
stavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvv

DLdKLQPEFMILASDGLWDAFSNEEAVRFIKERL-----DEPHFGAKSIVLQSFYR-GCPDNITVMVV
.| . . ||.||||||||| .||.|.| .....|      .|.  |. .. .   | |. |||||.||
tl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

PP2C Protein phosphatase 2C 94-344 6.3e-63 205.7 Pfam-A 4-255 (255) alignment
Range on Protein: 94-344
Range on HMM: 4-255/255.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILS-IDRE------Mlek
 . ..||.|..|||.   | .|     | . ..|..||||||. ||.| ...|.| ||.  ...| .       .. .| ...|. .| |      .   
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskan...

lTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngSWRVQGILAMSRSLGDYPLKN--LNVVIPD
 | . .  |.|...||...|.| |||||||| |||.||...  |. ||||.. .||.||..|||..|    .||.| ||.||.|||. ||.    .|...
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsae

PDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE---PHFGAKSIVLQSFYRGCPDNI
||. ...|..   ||.||||||||| .|..||| .....|..   |   |. .| ..  ||. |||
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 94-344 6.3e-63 205.7 In-house 4-255 (255) alignment
Range on Protein: 94-344
Range on HMM: 4-255/255.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILS-IDRE------Mlek
 . ..||.|..|||.   | .|     | . ..|..||||||. ||.| ...|.| ||.  ...| .       .. .| ...|. .| |      .   
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskan...

lTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngSWRVQGILAMSRSLGDYPLKN--LNVVIPD
 | . .  |.|...||...|.| |||||||| |||.||...  |. ||||.. .||.||..|||..|    .||.| ||.||.|||. ||.    .|...
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsae

PDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE---PHFGAKSIVLQSFYRGCPDNI
||. ...|..   ||.||||||||| .|..||| .....|..   |   |. .| ..  ||. |||
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 93-344 7.4e-62 202.1 In-house 3-259 (259) alignment
Range on Protein: 93-344
Range on HMM: 3-259/259.0
VAVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILSI--------DREMl
. . ..||.|..|||.  .| .|.    | . ..|..|||||| .||.|....|.|.||.  ...| .       .. .|  ..|..        .... 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelkssean.

eklTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKN----LNV
   |   .  |.|...||.....| |||||||| |||...... .|. ||||.  .||.||..|||..|  | .|| | ||.||..||. ||.      .
...t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeql

VIPDPDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE--PHFGAKSIVLQSFYRGCPDNI
|...||| . ..|.   ||.||||||||| .|..||| .....|..  |   |. .|  .  ||. |||
vsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni

0049733 PP2C-like 91-352 5.1e-59 192.3 In-house 3-234 (235) alignment
Range on Protein: 91-352
Range on HMM: 3-234/235.0
HNVAVYSIQGR-RDHMEDRFEVltdlanktHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDyekdkeNSVLSYQTILEQQILSIDREMLEKLTVS--
 .|...|..|| |...||.. |        . ..|...|||||  |.|.. ..|.|.|...|..       . |.....|.. .| .....||. . |  
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspe

YDEAGTTCLIALLSDKDLTVANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFIsfngswRVQGILAMSRSLGDYPLKnlnvvipdPDILTF
..  |||...||| .. |.|||||||| .|.. ||....|..||.|..  ||.||..|||..      || |.||..|.|||..||        ||. ..
lagmgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk........pdvtvl

DLDKLQpeFMILASDGLWDAFSNEEAVRFIKErlDEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
.|..    |..|||||||| .|.||.|.....  ....  |. .| . . || .|||||.||...
elepgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelalarggrDNiTvvvvrld

subfamily_PPM1G2_pd Subfamily PPM1G2 89-325 3.8e-58 189.7 In-house 17-251 (287) alignment
Range on Protein: 89-325
Range on HMM: 17-251/287.0
KNHNVAVYSIQGRRDHMEDRFEV---LTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQhlqdyekD---KENSVlsyQTILEQQILSIDREMLE
.. .|.  ..|| | .|||   .   | .. .... ..|..||||||...|.|. ..| . ...           ||...   ..||.. .|..|.|.|.
altkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.......kksfkegal...eqilkdafletDeellk

KLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNLN------
. ... ..||.|....|.....| |||.|||| ||. | ||.  || |||| . .|.|||. ||||...|   ||.| ||.||.|||.  |. .      
deklkdesaGstavvvlikeeklyvanaGDsravlssk.gnvkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpee

-VVIPDPDILTFDLDkLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH
 .|   ||.|. .||  . ||..|| ||.|| ..|.| | ...||| . .
qivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsga

subfamily_PPM1E_pd Subfamily PPM1E 90-351 2.5e-56 183.8 In-house 3-262 (265) alignment
Range on Protein: 90-351
Range on HMM: 3-262/265.0
NHNVAVYSIQGRRDHMEDRFEVLTD------LANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensvlsyqTILEQQILSIDREMLEK
...| .......| .||||. .| |      | .... . |..||||||  ||.| ...|.| | .. .. |  .        . |.. .  .|...|.|
eyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqk

LTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNlnVVIPDPD
 .    ..|.|  ..|.. . | || .|||...|. ..|.|. | . ||| . .|.|||. |||.. . | ||| |.|..||..||. ||.   |. ..|
aereklksGstavvvliekdqlyvaWlGDsqallv.rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkp..yvsgead

ILTFDLDKLQpEFMILASDGLWDAFSNEEAVRFIKERLDEPH----FGAKSIVLQSFYRGCPDNITVMVVKF
. ...||. . |..|||.||||| . .||.|. ..| | ...      ||..| ..  .|  |||||.|| .
vaeveldgse.eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 92-351 1.2e-55 181.6 In-house 7-253 (255) alignment
Range on Protein: 92-351
Range on HMM: 7-253/255.0
NVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVL-SYQTIlEQQIlsidremleklT--Vsy
.|.   . |||  |||.. .     .|..  .. .||||||..||..   .|.  |.. |. .. . ..|.  .|..| . ||           .     
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykei.stqi...........serp..

DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRVQGILAMSRSLGDYPLKNlnVVIPDPDIL-T
   |||   .|. ..   .||||||| |||.||| |  || |||| . .|.|||...||..  .  . || | ||.||.|||  |.    |.||||.  .
kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfleP..fvvpdPdlsqs

FDLdKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVKF
..  . . .|.||| ||.||  |.||||  . .   .|.  |. .  ... .|  |||.|.|.|.
lei.skkdkflilacdGiwdlisdeeaveivag.isdpekaaeklrdlayssGstdnisvivikl

subfamily_PPM1K_pd Subfamily PPM1K 91-353 1.9e-50 164.5 In-house 4-260 (263) alignment
Range on Protein: 91-353
Range on HMM: 4-260/263.0
HNVAVYSIQGRRDHMEDRFEVlTDLANKTHpsIFGIFDGHGGETAAEYVKSRLPEALKQHLqDYEKDkensvlsYQTILEQQILSIDREMLEKLTVS---
..| . |..|.|   |||... ..| ..     ...||||.| .||..| ..| . ||. | . |||        ...| .  . .|...   |. |   
esvGkdsliGkraenedrikl.keldpell..yvavfdGhaGsaaadfvhdklekilkrll.ekekd.......leivlknafeeldkklkrylefsvae

--YDEAGTTCLIALLSD-KDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN--GSWRVQGILAMSRSLGDYPLKNLNvVIPDP
  . ..|||  ..|| | ..| .|..|||| .|| ..|.|  |..||.| . .|..|||.|||....|  |  .| | |||.|||||  ||.   || .|
aellssGttatvsllrdGtelvlaslGdsrailc.rnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG.viatP

DILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN
.  ....|. .  |..| .||. .  ...|   ...    .|.  |.... |..  |. || |..|| ...
etkslkvdhaadsflvlitdgisfvvnsqelcdlvrl.chdpeeaahalteqalqygsednatavvvplga

subfamily_ILKAP_pd Subfamily ILKAP 98-323 2.1e-42 138.3 In-house 12-245 (293) alignment
Range on Protein: 98-323
Range on HMM: 12-245/293.0
IQGRRDHMEDRFEVLTDLANK--------THPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDyeKDKENSVLSYQTILEQQILSIDREMLEKLTVSY-
 .| |..|.|   .| || ..        .. | ...||||.|. |.|.....| . ....|    .|  .   . .  | .     |.|.|.. . .  
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk..sdvsakekeikkclvdsfkktdeefLklaskakP

-DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG--N---AIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNLNVvIPDP
    |.|  . |  |. | |||.|||. ||. |.   .   ...|..||.| ...|||||..|||..  .   ||.|.| .|||.||   |.| | |  |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGv.istP

DILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE
|.   .|..    |..|| ||||..||..|.|.|| . |..
dvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvled

subfamily_PPM1D_pd Subfamily PPM1D 92-322 7.9e-40 129.8 In-house 3-266 (309) alignment
Range on Protein: 92-322
Range on HMM: 3-266/309.0
NVAVYSIQGRRDHMEDRFEVLTDLANKT---HPSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVLSY----QTILEQQILSIDREMLEKL
.|.. . || | .|||.. . ..  ...   . .....||||||. ||......| . .|.. ...  .....||.        .....    .|  .. 
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkq.kkflssepedvleAireaflatheamkkkleeWpktk

TVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG-----NAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRV---------QG--------IL
.  .  ||||. . .. ...| ||.||||. ||  |.      .| .| .|||| ...|..||...|| .. . |  ||         .|         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

AMSRSLGDY----PLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLD
|..|||||       ..  || |.||.  . ||  . .|.||||||||.  . |.||.....   
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeee

subfamily_PPM1G_pd Subfamily PPM1G 189-325 8.7e-38 123.5 In-house 294-433 (473) alignment
Range on Protein: 189-325
Range on HMM: 294-433/473.0
DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLKNLN-------VVIPD
 ..|||  .||| .|.|.|||.|||| ||. . |.|. || ||||   .|..||..||| .  .|  ||.| | .|| |||.  |. .       ..   
edsGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmisAl

PDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH
||| .  | . . ||..||.||.|.. . .| | |....| . .
PDikvltlte.edeFlvlAcDGiWnvmesqevvdfvraklkkge

PPM_PTC7_SpoIIE 94-349 5.5e-33 107.7 In-house 4-227 (230) alignment
Range on Protein: 94-349
Range on HMM: 4-227/230.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETaaEYVKSRLPEALKQHLqDYEKDkensvlsyqtILEQQILSIDREMLE----Kltv
 . ..||.|..|||.  .. ...    .    ..|..|||||     .. ..| .||.    . . .           .|. .  .....      .   
gasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..........kpeeilrrlnlalaadlede...

sYDEAGTTCLIALLSDKD--LTVANVGDSRGVLCDKDGNaiplshdhkpyqlkERKRIkRAGGFISfN----GswRVQGILAMSRSLGDYPLKN-LNVVI
  .. |.|...||.   .  |.|||.|||. .|...||               ||.||  |||..|      |  || | ||.|.. ||. |.    || 
.psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglps.lGilpg..rvfgvlavslapGdllllytDGvve

PDPDiLTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPhfgaksivlqsFY-RGCPDNITVMVV
. ||    ....   ||.|||||||||  |..|.|......|..|           .. ..  | ||. ||
aepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp...........aaeglleDDitllvv

subfamily_KAPP-like_pd Subfamily KAPP-like 114-350 1.3e-32 105.8 In-house 27-265 (266) alignment
Range on Protein: 114-350
Range on HMM: 27-265/266.0
DLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD-KENSVLSYQTILEQQILSIDREMLEkltVSYDEAG-TTCLIALL-SDKDLTVANV
.|.| .. ..|..|||| |  ||.  |  .|. |...|.  ..|   ...   . .||. . ..| .. .     |. |  | .|.      . | ||||
klsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkd...feyeGatatlalvwsdGqqrylqvanv

GDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISfNGSWRVQGIlAMSRSLGDYPLKNLNV-VIPDPDILTFDLDKLQPEFMILASDGLWDAFS
|||   |.    ... ||.|||  . .|..|||  |  .| ..  |..|. |.||.|||. .|.||. .| .| .    |   . .|.|.|||||||  |
Gdssaflsr.GneslelskdhkakdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvis

NEEAVRFIKERLDEPHFGA--KSIVLQSFYR--GCPDNITVMVVK
 ..|.  .|   |.        | .|..  .   . ||..|.|||
Gkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 114-350 2.1e-28 92.0 In-house 26-275 (276) alignment
Range on Protein: 114-350
Range on HMM: 26-275/276.0
DLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQD--YEKDK----ENSVLSYQTILEQQILSIDREMLEkltVSYDEAG-TTCLIALLS-----
||.| .. ..|..|||| |  ||.  |  .|. |.. |.   |   |     ...   . .| . .  .| .. .     |. |  | .|.         
dlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkd...feyeGatatlalvwsdGeeqqq

--DKDLTVANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISfNGSWRVQGIlAMSRSLGDYPLKNLNV-VIPDPDILTFDLDKLQPEFMI
  .. | |||||||   |.    ... ||.|||  . .|..|||  |  .| ..  |..|. |.||.|||. .|.||. .| .| .    |   . .|.|
qqqrylqvanvGdssaflsr.GneslelskdhkatdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkfli

LASDGLWDAFSNEEAVRFIKERLDEPHFGA--KSIVLQSFYR--GCPDNITVMVVK
.|||||||  | ..|.  .|   |.        | .|..  .   . ||..|.|||
vasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 107-284 2.9e-25 82.4 In-house 9-196 (292) alignment
Range on Protein: 107-284
Range on HMM: 9-196/292.0
DRFEVLTDlaNKTHPSIFGIFDGHG--GETAAEYVKSRLPEALkqhLQDYEKDKENSvlsyqTILEQQILSIDREmLEKLTVSYD-EAGTTCLIALLSDK
||| ..     .. . .  ..||||  |.  |.. ...|   |   |. . . .| |       | ..||.|  . |.|||.    .|.|.   |   | 
drfllveg..sealtflaavldGhGvnGdkvaqlaedtlevel...leltrqlqels.....ealllrildiaak.ldkltidaresattavvcarvrdd

-DLTVANVGDSRGVLCD----KDGNAIPLSHDHKPYQLKERKRIKRAGGFIS--------FNGSWRV------QGILAMSRSLGDYPLKNLNVvIPDPDI
  | .||||||| .|       | . ||||.||||    ||.||.||||..         |.|. ||      .| ||.||.|||. |..  | . .|..
ralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGv.vaePel





subfamily_PP2D1_pd Subfamily PP2D1 205-322 1.4e-24 79.7 In-house 190-307 (492) alignment
Range on Protein: 205-322
Range on HMM: 190-307/492.0
LTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGS-WRVQGILAMSRSLGDYPLKNLN-VVIPDPDILTFDLDKLQpEFMILASD
| .||.|. . ||| . |.|| | ..| |.  |||.|...||. .. ..   .|.|||   | || |   .|.  |||.| . .  ||. .  |..||| 
lyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaa.qflvlAsn

GLWDAFSNEEAVRFIKERLD
|||. .|.|| .  .|. | 
GlWevlseeevlsLvkqtla

subfamily_PHLPP_pd Subfamily PHLPP 122-352 6.8e-22 70.6 In-house 28-246 (246) alignment
Range on Protein: 122-352
Range on HMM: 28-246/246.0
SIFGIFDGHggetAAEYVKSRLPEALKQHLQ-DYEKDKENSVLSYQTILEQQilsidRemleKLTVSYDEAGTTCLIALL-SDK-------DLTVANVGD
...|.|||.    ..|.. | |.. .|. |. . .|||.. .   .|.|  |     |    ||    .  |.. |. |.  ||        |.||.|| 
alyGlfdGd....rneelssllqrlmkdvlkeevqkdkneeeymkntllvaq.....r....klGeaGeklgsaallilirhdkvdPaksfsLevAsvGt

SRGVLCDKDGnAIPLSHDHKpYQLKERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLknLNVVIPDPDILTFDLDKlQPEFMILASDGLWDAFSNEE
   ||. .    ..||. ..  .  | |||| | ..|. ..  ...|... .| || . |    ||.|.| .    | . | |..|. .. ||. .| .|
lqavliRngk.klrlsksyv.iekdelkrikeakaiitedn..kingviestrllGytfl..fPvvlPkphvrevlLte.qdellivGnkalWevlside

AVRFIKERlDEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
||. ...  ..|   || .| .    |. |...|.||..|
aveavrke.edplvaAkklvdlaqsygaadsvsvlvvrlr

PP2C_SIG_SM00331 116-351 9.2e-21 67.4 In-house 25-217 (217) alignment
Range on Protein: 116-351
Range on HMM: 25-217/217.0
ANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYekdkensvlsyqTILEQQILSIDREMLEKltVSYDEAGTTCLIALL--SDKDLTVANVGDS
... .  .. ..||.|.  ||. . |.| .||...|..             . |.| .  ..| . |.     .. ..|.|.||.  |.. | .||.|||
klnegrlllvvaDgmGkGlaAaaassqlrtalrellseg............eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGds

RGVLCDKDGNAIPLSHdhkpyqlkerkrikraggfisfngswrvqgilAMSRSLGDYPLKNlnvvipdPDILTFDLDKlqPEFMILASDGLWDA-----F
| .| ....   .|..                                 ... ||  |  .       .|| ...|.|   ....|..|||..|     |
rpyllrdgklveilkd................................vegaplGlepevs.......vdirelelek..gdllllytDGltearsekgf

SNEEAVRFIKERLDEPHFGAKS---IVLQSFYRGC--PDNITVMVVKF
 .|.  ..... .|...   ..     | .. .|.  .|.|||.|||.
aeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvkv

Subfamily Dicty-PPM1L-like 235-352 5.9e-16 51.2 In-house 179-304 (305) alignment
Range on Protein: 235-352
Range on HMM: 179-304/305.0
QLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLnvVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGA------
. ..| ||  ... .   |  .| ..|  ||| ||  || |  |||..|   . . | . .|..|| ||||...|... | ..|| | .   .       
ldeiririeslqaalynygellvnrllkksrskGdknlkel..viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdf

----KSIVLQSFYRGCPDNITVMVVKFR
    . || ..  ||  ||||....|..
neisrviveeavkrgsgDnitlviiklk

subfamily_PPM1G_pd Subfamily PPM1G 88-163 2.1e-15 49.7 In-house 16-88 (473) alignment
Range on Protein: 88-163
Range on HMM: 16-88/473.0
FKNHNVAVYSIQGRRDHMEDRFEVLTDLANKThpSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVL
 ....... . || |. .||  ...||| ..|  |.|...|||||.  |.|| ..||. ||.. . |.... .. |
neelsygasamqGwrvsqEDahncitdldedt..slfavyDGHGGkevakyvakklpdllkaq.kgykegdvekal

Subfamily Dicty-PPM1L-like 186-279 1.7e-12 39.8 In-house 209-300 (305) alignment
Range on Protein: 186-279
Range on HMM: 209-300/305.0
VSYDEAGTTCLIALLSDKDL-TVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFI--SFNGSWRVQGILAMSRSLGDyplkNLNVVI
 |  . ....|..   |. |  ||. .|...||. .|| .  ||..... ..||  |.|  .. |   ||  .|| ...|..|  ||    | ..||
rskGdknlkelviPnndspllvvakanDqflvla.tdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD....nitlvi

PP2C_2 Protein phosphatase 2C 125-323 2e-12 39.8 Pfam-A 28-197 (212) alignment
Range on Protein: 125-323
Range on HMM: 28-197/212.0
GIFDGHG----GETAAEYVKSRLPEALKQHLQDYEKDK-ENSVLSYQTILEQQILSIDREMLEklTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCD
 . ||.|    .. .|... . . |||...|.. .... |  . . .. .....   .... .    . .. .||.|.|..... . ....||.. |. |
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd

KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngswrvqgilamsrslgdyplknlnvvipdpDILTFDldKLQPEFMILASDGLWDAFSNEEA-VRFIK
.||.. .|.....     |  .....  . ..                               .| ...  . ...  .| .||..|....||.  ....
rdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfrella

ERLDE
|.|..
ellet

PP2C_2 Protein phosphatase 2C 125-323 2e-12 39.8 In-house 28-197 (212) alignment
Range on Protein: 125-323
Range on HMM: 28-197/212.0
GIFDGHG----GETAAEYVKSRLPEALKQHLQDYEKDK-ENSVLSYQTILEQQILSIDREMLEklTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCD
 . ||.|    .. .|... . . |||...|.. .... |  . . .. .....   .... .    . .. .||.|.|..... . ....||.. |. |
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd

KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngswrvqgilamsrslgdyplknlnvvipdpDILTFDldKLQPEFMILASDGLWDAFSNEEA-VRFIK
.||.. .|.....     |  .....  . ..                               .| ...  . ...  .| .||..|....||.  ....
rdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfrella

ERLDE
|.|..
ellet

PPM_PTC7_motif 298-344 2.3e-11 37.0 In-house 1-51 (51) alignment
Range on Protein: 298-344
Range on HMM: 1-51/51.0
ILASDGLWDAFSNEEAVRFIKERLDE----PHFGAKSIVLQSFYRGCPDNI
||||||||| .|..||| .....|..    |   |. .| ..  ||. |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

Subfamily Dicty-PPM1L-like 94-151 2.4e-11 36.0 In-house 10-67 (305) alignment
Range on Protein: 94-151
Range on HMM: 10-67/305.0
AVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHL
 .|  .. | . ||| .|   | .. . |.||.||||.|. |||||| .| | . ...
elyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyv

subfamily_PDP_pd Subfamily PDP 185-245 3.8e-11 35.7 In-house 146-210 (398) alignment
Range on Protein: 185-245
Range on HMM: 146-210/398.0
TVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNA----IPLSHDHKPYQLKERKRIKRA
..    .|...|.||.....| |||.||.| ||. .....    ..||.|.     .| .|||..
allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke

subfamily_PPM1H_pd Subfamily PPM1H 169-244 4.8e-11 35.1 In-house 140-212 (404) alignment
Range on Protein: 169-244
Range on HMM: 140-212/404.0
LEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYqlKERKRIKR
||.  |..|  . .  .   .. | | |.||. .. | ||| |||| .|. . .. ||||.|. |    ||.|...
lesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailv.rkdeiiplsadftPe..teRqRlqe

subfamily_TAB1_pd Subfamily TAB1 191-275 6.6e-11 34.6 In-house 129-215 (333) alignment
Range on Protein: 191-275
Range on HMM: 129-215/333.0
AGTTCLIALLSDKDLTVANVGDSRGVLCD--KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNL
 ||| ..||.  ..| |||||||| .|.   .  .   || ||.    .| .|.|. |  |    . .. |     ||.||| .|..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkg

subfamily_PP2D1_pd Subfamily PP2D1 104-157 3e-10 32.4 In-house 16-69 (492) alignment
Range on Protein: 104-157
Range on HMM: 16-69/492.0
HMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD
.|||.. .  . .|... . |||.||. | ||||   . |.| | ..|.  .. 
kmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvder

subfamily_PPM1H_pd Subfamily PPM1H 256-323 3e-09 29.1 In-house 276-353 (404) alignment
Range on Protein: 256-323
Range on HMM: 276-353/404.0
RVQGILAMSRSLGDYPLKNLN-------VVIPDPDILTFDLDKLQ---PEFMILASDGLWDAFSNEEAVRFIKERLDE
|. . ....| |||. || ..       .. | |.. ..||....    . .|||.|||||  ||||. . ..| |..
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk

subfamily_PDP_pd Subfamily PDP 281-324 1.6e-08 27.1 In-house 273-315 (398) alignment
Range on Protein: 281-324
Range on HMM: 273-315/398.0
DPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEP
.|....  | . .  |..||.||||| .||||.|. ..| |.. 
ePevtshklre.ndkFLvlatDGLwdllsneevvslVgehlakk

subfamily_TAB1_pd Subfamily TAB1 103-185 1.9e-07 23.2 In-house 12-87 (333) alignment
Range on Protein: 103-185
Range on HMM: 12-87/333.0
DHMEDRFEVLtdlANKTHPSIFGIFDGHGGETAAEYVKSRLPEA-LKQHLQDYEKDKEnsvlsYQTILEQQILSIDREMLEKLT
...||.. ..     . .| ....|||. |. ||..|. ||.   |...|.|  .. |      . .|.... ...|..||.. 
hevedkvflf...ktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeae.....vkevlkrafeeverkflesid

subfamily_PDP_pd Subfamily PDP 105-163 2.8e-07 23.0 In-house 11-69 (398) alignment
Range on Protein: 105-163
Range on HMM: 11-69/398.0
MEDRFEVLTDLanKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSVL
.|||  . . |  ...  .||.|||||| ..|| |. ||.. . ..| . ..  . |. . 
iEDrrseakll..esngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekale

PPM_PTC7_SpoIIE_motif 297-351 2.9e-06 20.9 In-house 15-80 (81) alignment
Range on Protein: 297-351
Range on HMM: 15-80/81.0
MILASDGLW-------DAFSNEEAVRFIKERldE---PHFGAKSIVLQSFYRG---CPDNITVMVVKF
..|..|||.       . |..||..|.....  |   .   |. .| .   .|   . |.||..|...
llLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlrv

SpoIIE Stage II sporulation protein E (SpoIIE) 126-320 9.9e-06 17.5 Pfam-A 9-149 (193) alignment
Range on Protein: 126-320
Range on HMM: 9-149/193.0
IFDGHGGETAAEYVKSRLPEALKQHLQDYEKdkensvlsyqtiLEQQILSIDREMLEKLTVSydEAGTTCLIAL--LSDKDLTVANVGDSRGVLCDKDGn
. |. |   .|  . ..| .||.. ...  .            ... .  ... . ..|. .  | ..|...|   .|.. |..||.|..  .|...|| 
vgDvvGhGleAalimgllrsalrelatagle............paevlerlnealarnleee..erfatavlaeydpstgkleyanaGhpppllvrpdg.

aiplshdhkpyqlKE---------------RkrikraggfisfngswrvqgilamsrslgdyplknlnvviPDPDILTFDLDKlqPEFMILASDGLWDAF
             ..                                                         |..  ...|..   . ..|..||. .| 
.............gtkfllvstglplGilpe........................................adyeeaelqlep..gdllllyTDGvtEar

sNEEAVRFIKER
 ...   | |||
.dpdgelfgker

SpoIIE Stage II sporulation protein E (SpoIIE) 126-320 9.9e-06 17.5 In-house 9-149 (193) alignment
Range on Protein: 126-320
Range on HMM: 9-149/193.0
IFDGHGGETAAEYVKSRLPEALKQHLQDYEKdkensvlsyqtiLEQQILSIDREMLEKLTVSydEAGTTCLIAL--LSDKDLTVANVGDSRGVLCDKDGn
. |. |   .|  . ..| .||.. ...  .            ... .  ... . ..|. .  | ..|...|   .|.. |..||.|..  .|...|| 
vgDvvGhGleAalimgllrsalrelatagle............paevlerlnealarnleee..erfatavlaeydpstgkleyanaGhpppllvrpdg.

aiplshdhkpyqlKE---------------RkrikraggfisfngswrvqgilamsrslgdyplknlnvviPDPDILTFDLDKlqPEFMILASDGLWDAF
             ..                                                         |..  ...|..   . ..|..||. .| 
.............gtkfllvstglplGilpe........................................adyeeaelqlep..gdllllyTDGvtEar

sNEEAVRFIKER
 ...   | |||
.dpdgelfgker