Gene PPM1L in Homo sapiens

Synonym: PP2C-epsilon, PP2CE, PPM1-LIKE, PPM1L

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1L
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP185_AA protein Get Run
HsapP185_AA_84-353 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1L_pd Subfamily PPM1L 87-354 1.7e-152 499.2 In-house 1-269 (269) alignment 
Range on Protein: 87-354
Range on HMM: 1-269/269.0
EFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSV-LSYQTILEQQILSIDREMLEKLT
|.|...|||||..|||..||||||. .|..|||..|.|..|||||||.|||..|..|..|.|..|.....||||.. ......|...|||.|...|||..
eekkqqvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekak

VSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDIL
...|.||||.||||....||.|||||||||||.||.|.|||||.||||.|.|||||||.|||||.|.|.|||.|.||.||.|||||||. |.||.|||||
raediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdil

TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNS
|||||...|||.|||||||||.||||||||||||||.||.|||||.||.||.||..|||||.|||..|.
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklknd
0034914 PP2C-like 85-353 1e-76 250.5 In-house 15-292 (295) alignment 
Range on Protein: 85-353
Range on HMM: 15-292/295.0
TWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLAN-KTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEK
...  ...|.|.|.||||...||.. |...| .  .. ..||.|||||| .|||.....|.|.|...|. .    ..|  .....|.. .|..|.|.||.
sslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

LTV--SYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngsWRVQGILAMSRSLGDYPLKNL------
.    ...  |||...||. .. |.|||||||| ||. ..| ...|..||||..  ||.||..|||..|.   .|| |.||..|.|||..||.|      
allrpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllsllll

-NVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKER---LDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN
  .|.. ||. ...|.  . .|..|||||||| .||||.|......    ....  |. .| ... ||. |||||.||....
eplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1A_pd Subfamily PPM1A 89-352 4.2e-69 226.0 In-house 10-281 (282) alignment 
Range on Protein: 89-352
Range on HMM: 10-281/282.0
KNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQH--LQDyEKDKENSVLSYQTILEQQILSIDREMLEKLTV
..  ..| | ||.| .|||...| ..|.. .. | | .||||.|...|.|||. |.|.. ..  |.. .. ....  ...  |.|..|..| .. |. | 
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.aaleasekdevkealrqgfLaldeairelstd

SY--DEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISfngSWRVQGILAMSRSLGDYPLKN-------LNV
.   |..|.|.. .|.|.| | .||.||||.||| ..|.|. |..||||.. ||.|||. |||..      ||.| ||.||.|||| .|.          
lktadksGsTavtvlvsekhliianlGDsRavlc.rngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeql

VIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERL---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
|...|.. ... .. .  |..||.||.||  |.||.| ....||   ||..  ||..| ... .|  ||..|.|| | 
vsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PP2Cc_SM00332 96-349 1.2e-68 224.5 In-house 15-274 (274) alignment 
Range on Protein: 96-349
Range on HMM: 15-274/274.0
YSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensVLSYQTILEQQILSIDREMLEKLTVSYD---EAG
 | ||.|. |||.. | .|| ...  ..||.||||||. .|..|...||||||..|.  ....     . . .|.. .||.| |.||.  .. .    .|
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeileeeqskelenalsG

TTCLIALLSDKDLTVANVGDSRGVLCDKDGnAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLK-----NLNVVIPDPDILTF
.|...|||...|| |||||||| ||| ..  |..|| |||| . .||||||.|||.....   ||.| ||.||..||. ||     .  .....||. . 
stavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvv

DLdKLQPEFMILASDGLWDAFSNEEAVRFIKERL-----DEPHFGAKSIVLQSFYR-GCPDNITVMVV
.| . . ||.||||||||| .||.|.| .....|      .|.  |. .. .   | |. |||||.||
tl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 94-344 6.3e-63 205.7 Pfam-A 4-255 (255) alignment 
Range on Protein: 94-344
Range on HMM: 4-255/255.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILS-IDRE------Mlek
 . ..||.|..|||.   | .|     | . ..|..||||||. ||.| ...|.| ||.  ...| .       .. .| ...|. .| |      .   
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskan...

lTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngSWRVQGILAMSRSLGDYPLKN--LNVVIPD
 | . .  |.|...||...|.| |||||||| |||.||...  |. ||||.. .||.||..|||..|    .||.| ||.||.|||. ||.    .|...
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsae

PDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE---PHFGAKSIVLQSFYRGCPDNI
||. ...|..   ||.||||||||| .|..||| .....|..   |   |. .| ..  ||. |||
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 94-344 6.3e-63 205.7 In-house 4-255 (255) alignment 
Range on Protein: 94-344
Range on HMM: 4-255/255.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILS-IDRE------Mlek
 . ..||.|..|||.   | .|     | . ..|..||||||. ||.| ...|.| ||.  ...| .       .. .| ...|. .| |      .   
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskan...

lTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngSWRVQGILAMSRSLGDYPLKN--LNVVIPD
 | . .  |.|...||...|.| |||||||| |||.||...  |. ||||.. .||.||..|||..|    .||.| ||.||.|||. ||.    .|...
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsae

PDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE---PHFGAKSIVLQSFYRGCPDNI
||. ...|..   ||.||||||||| .|..||| .....|..   |   |. .| ..  ||. |||
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 93-344 7.4e-62 202.1 In-house 3-259 (259) alignment 
Range on Protein: 93-344
Range on HMM: 3-259/259.0
VAVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDkensvlSYQTILEQQILSI--------DREMl
. . ..||.|..|||.  .| .|.    | . ..|..|||||| .||.|....|.|.||.  ...| .       .. .|  ..|..        .... 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelkssean.

eklTvSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKN----LNV
   |   .  |.|...||.....| |||||||| |||...... .|. ||||.  .||.||..|||..|  | .|| | ||.||..||. ||.      .
...t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeql

VIPDPDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE--PHFGAKSIVLQSFYRGCPDNI
|...||| . ..|.   ||.||||||||| .|..||| .....|..  |   |. .|  .  ||. |||
vsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
0049733 PP2C-like 91-352 5.1e-59 192.3 In-house 3-234 (235) alignment 
Range on Protein: 91-352
Range on HMM: 3-234/235.0
HNVAVYSIQGR-RDHMEDRFEVltdlanktHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDyekdkeNSVLSYQTILEQQILSIDREMLEKLTVS--
 .|...|..|| |...||.. |        . ..|...|||||  |.|.. ..|.|.|...|..       . |.....|.. .| .....||. . |  
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspe

YDEAGTTCLIALLSDKDLTVANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFIsfngswRVQGILAMSRSLGDYPLKnlnvvipdPDILTF
..  |||...||| .. |.|||||||| .|.. ||....|..||.|..  ||.||..|||..      || |.||..|.|||..||        ||. ..
lagmgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk........pdvtvl

DLDKLQpeFMILASDGLWDAFSNEEAVRFIKErlDEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
.|..    |..|||||||| .|.||.|.....  ....  |. .| . . || .|||||.||...
elepgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G2_pd Subfamily PPM1G2 89-325 3.8e-58 189.7 In-house 17-251 (287) alignment 
Range on Protein: 89-325
Range on HMM: 17-251/287.0
KNHNVAVYSIQGRRDHMEDRFEV---LTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQhlqdyekD---KENSVlsyQTILEQQILSIDREMLE
.. .|.  ..|| | .|||   .   | .. .... ..|..||||||...|.|. ..| . ...           ||...   ..||.. .|..|.|.|.
altkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.......kksfkegal...eqilkdafletDeellk

KLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNLN------
. ... ..||.|....|.....| |||.|||| ||. | ||.  || |||| . .|.|||. ||||...|   ||.| ||.||.|||.  |. .      
deklkdesaGstavvvlikeeklyvanaGDsravlssk.gnvkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpee

-VVIPDPDILTFDLDkLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH
 .|   ||.|. .||  . ||..|| ||.|| ..|.| | ...||| . .
qivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsga
subfamily_PPM1E_pd Subfamily PPM1E 90-351 2.5e-56 183.8 In-house 3-262 (265) alignment 
Range on Protein: 90-351
Range on HMM: 3-262/265.0
NHNVAVYSIQGRRDHMEDRFEVLTD------LANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensvlsyqTILEQQILSIDREMLEK
...| .......| .||||. .| |      | .... . |..||||||  ||.| ...|.| | .. .. |  .        . |.. .  .|...|.|
eyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqk

LTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNlnVVIPDPD
 .    ..|.|  ..|.. . | || .|||...|. ..|.|. | . ||| . .|.|||. |||.. . | ||| |.|..||..||. ||.   |. ..|
aereklksGstavvvliekdqlyvaWlGDsqallv.rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkp..yvsgead

ILTFDLDKLQpEFMILASDGLWDAFSNEEAVRFIKERLDEPH----FGAKSIVLQSFYRGCPDNITVMVVKF
. ...||. . |..|||.||||| . .||.|. ..| | ...      ||..| ..  .|  |||||.|| .
vaeveldgse.eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 92-351 1.2e-55 181.6 In-house 7-253 (255) alignment 
Range on Protein: 92-351
Range on HMM: 7-253/255.0
NVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVL-SYQTIlEQQIlsidremleklT--Vsy
.|.   . |||  |||.. .     .|..  .. .||||||..||..   .|.  |.. |. .. . ..|.  .|..| . ||           .     
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykei.stqi...........serp..

DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRVQGILAMSRSLGDYPLKNlnVVIPDPDIL-T
   |||   .|. ..   .||||||| |||.||| |  || |||| . .|.|||...||..  .  . || | ||.||.|||  |.    |.||||.  .
kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfleP..fvvpdPdlsqs

FDLdKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVKF
..  . . .|.||| ||.||  |.||||  . .   .|.  |. .  ... .|  |||.|.|.|.
lei.skkdkflilacdGiwdlisdeeaveivag.isdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1K_pd Subfamily PPM1K 91-353 1.9e-50 164.5 In-house 4-260 (263) alignment 
Range on Protein: 91-353
Range on HMM: 4-260/263.0
HNVAVYSIQGRRDHMEDRFEVlTDLANKTHpsIFGIFDGHGGETAAEYVKSRLPEALKQHLqDYEKDkensvlsYQTILEQQILSIDREMLEKLTVS---
..| . |..|.|   |||... ..| ..     ...||||.| .||..| ..| . ||. | . |||        ...| .  . .|...   |. |   
esvGkdsliGkraenedrikl.keldpell..yvavfdGhaGsaaadfvhdklekilkrll.ekekd.......leivlknafeeldkklkrylefsvae

--YDEAGTTCLIALLSD-KDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN--GSWRVQGILAMSRSLGDYPLKNLNvVIPDP
  . ..|||  ..|| | ..| .|..|||| .|| ..|.|  |..||.| . .|..|||.|||....|  |  .| | |||.|||||  ||.   || .|
aellssGttatvsllrdGtelvlaslGdsrailc.rnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG.viatP

DILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN
.  ....|. .  |..| .||. .  ...|   ...    .|.  |.... |..  |. || |..|| ...
etkslkvdhaadsflvlitdgisfvvnsqelcdlvrl.chdpeeaahalteqalqygsednatavvvplga
subfamily_ILKAP_pd Subfamily ILKAP 98-323 2.1e-42 138.3 In-house 12-245 (293) alignment 
Range on Protein: 98-323
Range on HMM: 12-245/293.0
IQGRRDHMEDRFEVLTDLANK--------THPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDyeKDKENSVLSYQTILEQQILSIDREMLEKLTVSY-
 .| |..|.|   .| || ..        .. | ...||||.|. |.|.....| . ....|    .|  .   . .  | .     |.|.|.. . .  
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk..sdvsakekeikkclvdsfkktdeefLklaskakP

-DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG--N---AIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNLNVvIPDP
    |.|  . |  |. | |||.|||. ||. |.   .   ...|..||.| ...|||||..|||..  .   ||.|.| .|||.||   |.| | |  |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGv.istP

DILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE
|.   .|..    |..|| ||||..||..|.|.|| . |..
dvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvled
subfamily_PPM1D_pd Subfamily PPM1D 92-322 7.9e-40 129.8 In-house 3-266 (309) alignment 
Range on Protein: 92-322
Range on HMM: 3-266/309.0
NVAVYSIQGRRDHMEDRFEVLTDLANKT---HPSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVLSY----QTILEQQILSIDREMLEKL
.|.. . || | .|||.. . ..  ...   . .....||||||. ||......| . .|.. ...  .....||.        .....    .|  .. 
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkq.kkflssepedvleAireaflatheamkkkleeWpktk

TVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG-----NAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRV---------QG--------IL
.  .  ||||. . .. ...| ||.||||. ||  |.      .| .| .|||| ...|..||...|| .. . |  ||         .|         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

AMSRSLGDY----PLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLD
|..|||||       ..  || |.||.  . ||  . .|.||||||||.  . |.||.....   
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeee
subfamily_PPM1G_pd Subfamily PPM1G 189-325 8.7e-38 123.5 In-house 294-433 (473) alignment 
Range on Protein: 189-325
Range on HMM: 294-433/473.0
DEAGTTCLIALLSDKDLTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLKNLN-------VVIPD
 ..|||  .||| .|.|.|||.|||| ||. . |.|. || ||||   .|..||..||| .  .|  ||.| | .|| |||.  |. .       ..   
edsGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmisAl

PDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH
||| .  | . . ||..||.||.|.. . .| | |....| . .
PDikvltlte.edeFlvlAcDGiWnvmesqevvdfvraklkkge
PPM_PTC7_SpoIIE 94-349 5.5e-33 107.7 In-house 4-227 (230) alignment 
Range on Protein: 94-349
Range on HMM: 4-227/230.0
AVYSIQGRRDHMEDRFEVLTDLA---NKTHPSIFGIFDGHGGETaaEYVKSRLPEALKQHLqDYEKDkensvlsyqtILEQQILSIDREMLE----Kltv
 . ..||.|..|||.  .. ...    .    ..|..|||||     .. ..| .||.    . . .           .|. .  .....      .   
gasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..........kpeeilrrlnlalaadlede...

sYDEAGTTCLIALLSDKD--LTVANVGDSRGVLCDKDGNaiplshdhkpyqlkERKRIkRAGGFISfN----GswRVQGILAMSRSLGDYPLKN-LNVVI
  .. |.|...||.   .  |.|||.|||. .|...||               ||.||  |||..|      |  || | ||.|.. ||. |.    || 
.psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglps.lGilpg..rvfgvlavslapGdllllytDGvve

PDPDiLTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPhfgaksivlqsFY-RGCPDNITVMVV
. ||    ....   ||.|||||||||  |..|.|......|..|           .. ..  | ||. ||
aepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp...........aaeglleDDitllvv
subfamily_KAPP-like_pd Subfamily KAPP-like 114-350 1.3e-32 105.8 In-house 27-265 (266) alignment 
Range on Protein: 114-350
Range on HMM: 27-265/266.0
DLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD-KENSVLSYQTILEQQILSIDREMLEkltVSYDEAG-TTCLIALL-SDKDLTVANV
.|.| .. ..|..|||| |  ||.  |  .|. |...|.  ..|   ...   . .||. . ..| .. .     |. |  | .|.      . | ||||
klsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkd...feyeGatatlalvwsdGqqrylqvanv

GDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISfNGSWRVQGIlAMSRSLGDYPLKNLNV-VIPDPDILTFDLDKLQPEFMILASDGLWDAFS
|||   |.    ... ||.|||  . .|..|||  |  .| ..  |..|. |.||.|||. .|.||. .| .| .    |   . .|.|.|||||||  |
Gdssaflsr.GneslelskdhkakdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvis

NEEAVRFIKERLDEPHFGA--KSIVLQSFYR--GCPDNITVMVVK
 ..|.  .|   |.        | .|..  .   . ||..|.|||
Gkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 114-350 2.1e-28 92.0 In-house 26-275 (276) alignment 
Range on Protein: 114-350
Range on HMM: 26-275/276.0
DLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQD--YEKDK----ENSVLSYQTILEQQILSIDREMLEkltVSYDEAG-TTCLIALLS-----
||.| .. ..|..|||| |  ||.  |  .|. |.. |.   |   |     ...   . .| . .  .| .. .     |. |  | .|.         
dlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkd...feyeGatatlalvwsdGeeqqq

--DKDLTVANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISfNGSWRVQGIlAMSRSLGDYPLKNLNV-VIPDPDILTFDLDKLQPEFMI
  .. | |||||||   |.    ... ||.|||  . .|..|||  |  .| ..  |..|. |.||.|||. .|.||. .| .| .    |   . .|.|
qqqrylqvanvGdssaflsr.GneslelskdhkatdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkfli

LASDGLWDAFSNEEAVRFIKERLDEPHFGA--KSIVLQSFYR--GCPDNITVMVVK
.|||||||  | ..|.  .|   |.        | .|..  .   . ||..|.|||
vasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 107-284 2.9e-25 82.4 In-house 9-196 (292) alignment 
Range on Protein: 107-284
Range on HMM: 9-196/292.0
DRFEVLTDlaNKTHPSIFGIFDGHG--GETAAEYVKSRLPEALkqhLQDYEKDKENSvlsyqTILEQQILSIDREmLEKLTVSYD-EAGTTCLIALLSDK
||| ..     .. . .  ..||||  |.  |.. ...|   |   |. . . .| |       | ..||.|  . |.|||.    .|.|.   |   | 
drfllveg..sealtflaavldGhGvnGdkvaqlaedtlevel...leltrqlqels.....ealllrildiaak.ldkltidaresattavvcarvrdd

-DLTVANVGDSRGVLCD----KDGNAIPLSHDHKPYQLKERKRIKRAGGFIS--------FNGSWRV------QGILAMSRSLGDYPLKNLNVvIPDPDI
  | .||||||| .|       | . ||||.||||    ||.||.||||..         |.|. ||      .| ||.||.|||. |..  | . .|..
ralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGv.vaePel
subfamily_PP2D1_pd Subfamily PP2D1 205-322 1.4e-24 79.7 In-house 190-307 (492) alignment 
Range on Protein: 205-322
Range on HMM: 190-307/492.0
LTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGS-WRVQGILAMSRSLGDYPLKNLN-VVIPDPDILTFDLDKLQpEFMILASD
| .||.|. . ||| . |.|| | ..| |.  |||.|...||. .. ..   .|.|||   | || |   .|.  |||.| . .  ||. .  |..||| 
lyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaa.qflvlAsn

GLWDAFSNEEAVRFIKERLD
|||. .|.|| .  .|. | 
GlWevlseeevlsLvkqtla
subfamily_PHLPP_pd Subfamily PHLPP 122-352 6.8e-22 70.6 In-house 28-246 (246) alignment 
Range on Protein: 122-352
Range on HMM: 28-246/246.0
SIFGIFDGHggetAAEYVKSRLPEALKQHLQ-DYEKDKENSVLSYQTILEQQilsidRemleKLTVSYDEAGTTCLIALL-SDK-------DLTVANVGD
...|.|||.    ..|.. | |.. .|. |. . .|||.. .   .|.|  |     |    ||    .  |.. |. |.  ||        |.||.|| 
alyGlfdGd....rneelssllqrlmkdvlkeevqkdkneeeymkntllvaq.....r....klGeaGeklgsaallilirhdkvdPaksfsLevAsvGt

SRGVLCDKDGnAIPLSHDHKpYQLKERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLknLNVVIPDPDILTFDLDKlQPEFMILASDGLWDAFSNEE
   ||. .    ..||. ..  .  | |||| | ..|. ..  ...|... .| || . |    ||.|.| .    | . | |..|. .. ||. .| .|
lqavliRngk.klrlsksyv.iekdelkrikeakaiitedn..kingviestrllGytfl..fPvvlPkphvrevlLte.qdellivGnkalWevlside

AVRFIKERlDEPHFGAKSIVLQSFYRGCPDNITVMVVKFR
||. ...  ..|   || .| .    |. |...|.||..|
aveavrke.edplvaAkklvdlaqsygaadsvsvlvvrlr
PP2C_SIG_SM00331 116-351 9.2e-21 67.4 In-house 25-217 (217) alignment 
Range on Protein: 116-351
Range on HMM: 25-217/217.0
ANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYekdkensvlsyqTILEQQILSIDREMLEKltVSYDEAGTTCLIALL--SDKDLTVANVGDS
... .  .. ..||.|.  ||. . |.| .||...|..             . |.| .  ..| . |.     .. ..|.|.||.  |.. | .||.|||
klnegrlllvvaDgmGkGlaAaaassqlrtalrellseg............eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGds

RGVLCDKDGNAIPLSHdhkpyqlkerkrikraggfisfngswrvqgilAMSRSLGDYPLKNlnvvipdPDILTFDLDKlqPEFMILASDGLWDA-----F
| .| ....   .|..                                 ... ||  |  .       .|| ...|.|   ....|..|||..|     |
rpyllrdgklveilkd................................vegaplGlepevs.......vdirelelek..gdllllytDGltearsekgf

SNEEAVRFIKERLDEPHFGAKS---IVLQSFYRGC--PDNITVMVVKF
 .|.  ..... .|...   ..     | .. .|.  .|.|||.|||.
aeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvkv
Subfamily Dicty-PPM1L-like 235-352 5.9e-16 51.2 In-house 179-304 (305) alignment 
Range on Protein: 235-352
Range on HMM: 179-304/305.0
QLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLnvVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGA------
. ..| ||  ... .   |  .| ..|  ||| ||  || |  |||..|   . . | . .|..|| ||||...|... | ..|| | .   .       
ldeiririeslqaalynygellvnrllkksrskGdknlkel..viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdf

----KSIVLQSFYRGCPDNITVMVVKFR
    . || ..  ||  ||||....|..
neisrviveeavkrgsgDnitlviiklk
subfamily_PPM1G_pd Subfamily PPM1G 88-163 2.1e-15 49.7 In-house 16-88 (473) alignment 
Range on Protein: 88-163
Range on HMM: 16-88/473.0
FKNHNVAVYSIQGRRDHMEDRFEVLTDLANKThpSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVL
 ....... . || |. .||  ...||| ..|  |.|...|||||.  |.|| ..||. ||.. . |.... .. |
neelsygasamqGwrvsqEDahncitdldedt..slfavyDGHGGkevakyvakklpdllkaq.kgykegdvekal
Subfamily Dicty-PPM1L-like 186-279 1.7e-12 39.8 In-house 209-300 (305) alignment 
Range on Protein: 186-279
Range on HMM: 209-300/305.0
VSYDEAGTTCLIALLSDKDL-TVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFI--SFNGSWRVQGILAMSRSLGDyplkNLNVVI
 |  . ....|..   |. |  ||. .|...||. .|| .  ||..... ..||  |.|  .. |   ||  .|| ...|..|  ||    | ..||
rskGdknlkelviPnndspllvvakanDqflvla.tdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD....nitlvi
PP2C_2 Protein phosphatase 2C 125-323 2e-12 39.8 Pfam-A 28-197 (212) alignment 
Range on Protein: 125-323
Range on HMM: 28-197/212.0
GIFDGHG----GETAAEYVKSRLPEALKQHLQDYEKDK-ENSVLSYQTILEQQILSIDREMLEklTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCD
 . ||.|    .. .|... . . |||...|.. .... |  . . .. .....   .... .    . .. .||.|.|..... . ....||.. |. |
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd

KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngswrvqgilamsrslgdyplknlnvvipdpDILTFDldKLQPEFMILASDGLWDAFSNEEA-VRFIK
.||.. .|.....     |  .....  . ..                               .| ...  . ...  .| .||..|....||.  ....
rdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfrella

ERLDE
|.|..
ellet
PP2C_2 Protein phosphatase 2C 125-323 2e-12 39.8 In-house 28-197 (212) alignment 
Range on Protein: 125-323
Range on HMM: 28-197/212.0
GIFDGHG----GETAAEYVKSRLPEALKQHLQDYEKDK-ENSVLSYQTILEQQILSIDREMLEklTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCD
 . ||.|    .. .|... . . |||...|.. .... |  . . .. .....   .... .    . .. .||.|.|..... . ....||.. |. |
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd

KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFngswrvqgilamsrslgdyplknlnvvipdpDILTFDldKLQPEFMILASDGLWDAFSNEEA-VRFIK
.||.. .|.....     |  .....  . ..                               .| ...  . ...  .| .||..|....||.  ....
rdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfrella

ERLDE
|.|..
ellet
PPM_PTC7_motif 298-344 2.3e-11 37.0 In-house 1-51 (51) alignment 
Range on Protein: 298-344
Range on HMM: 1-51/51.0
ILASDGLWDAFSNEEAVRFIKERLDE----PHFGAKSIVLQSFYRGCPDNI
||||||||| .|..||| .....|..    |   |. .| ..  ||. |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
Subfamily Dicty-PPM1L-like 94-151 2.4e-11 36.0 In-house 10-67 (305) alignment 
Range on Protein: 94-151
Range on HMM: 10-67/305.0
AVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHL
 .|  .. | . ||| .|   | .. . |.||.||||.|. |||||| .| | . ...
elyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyv
subfamily_PDP_pd Subfamily PDP 185-245 3.8e-11 35.7 In-house 146-210 (398) alignment 
Range on Protein: 185-245
Range on HMM: 146-210/398.0
TVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNA----IPLSHDHKPYQLKERKRIKRA
..    .|...|.||.....| |||.||.| ||. .....    ..||.|.     .| .|||..
allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke
subfamily_PPM1H_pd Subfamily PPM1H 169-244 4.8e-11 35.1 In-house 140-212 (404) alignment 
Range on Protein: 169-244
Range on HMM: 140-212/404.0
LEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYqlKERKRIKR
||.  |..|  . .  .   .. | | |.||. .. | ||| |||| .|. . .. ||||.|. |    ||.|...
lesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailv.rkdeiiplsadftPe..teRqRlqe
subfamily_TAB1_pd Subfamily TAB1 191-275 6.6e-11 34.6 In-house 129-215 (333) alignment 
Range on Protein: 191-275
Range on HMM: 129-215/333.0
AGTTCLIALLSDKDLTVANVGDSRGVLCD--KDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNL
 ||| ..||.  ..| |||||||| .|.   .  .   || ||.    .| .|.|. |  |    . .. |     ||.||| .|..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkg
subfamily_PP2D1_pd Subfamily PP2D1 104-157 3e-10 32.4 In-house 16-69 (492) alignment 
Range on Protein: 104-157
Range on HMM: 16-69/492.0
HMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD
.|||.. .  . .|... . |||.||. | ||||   . |.| | ..|.  .. 
kmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvder
subfamily_PPM1H_pd Subfamily PPM1H 256-323 3e-09 29.1 In-house 276-353 (404) alignment 
Range on Protein: 256-323
Range on HMM: 276-353/404.0
RVQGILAMSRSLGDYPLKNLN-------VVIPDPDILTFDLDKLQ---PEFMILASDGLWDAFSNEEAVRFIKERLDE
|. . ....| |||. || ..       .. | |.. ..||....    . .|||.|||||  ||||. . ..| |..
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk
subfamily_PDP_pd Subfamily PDP 281-324 1.6e-08 27.1 In-house 273-315 (398) alignment 
Range on Protein: 281-324
Range on HMM: 273-315/398.0
DPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEP
.|....  | . .  |..||.||||| .||||.|. ..| |.. 
ePevtshklre.ndkFLvlatDGLwdllsneevvslVgehlakk
subfamily_TAB1_pd Subfamily TAB1 103-185 1.9e-07 23.2 In-house 12-87 (333) alignment 
Range on Protein: 103-185
Range on HMM: 12-87/333.0
DHMEDRFEVLtdlANKTHPSIFGIFDGHGGETAAEYVKSRLPEA-LKQHLQDYEKDKEnsvlsYQTILEQQILSIDREMLEKLT
...||.. ..     . .| ....|||. |. ||..|. ||.   |...|.|  .. |      . .|.... ...|..||.. 
hevedkvflf...ktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeae.....vkevlkrafeeverkflesid
subfamily_PDP_pd Subfamily PDP 105-163 2.8e-07 23.0 In-house 11-69 (398) alignment 
Range on Protein: 105-163
Range on HMM: 11-69/398.0
MEDRFEVLTDLanKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSVL
.|||  . . |  ...  .||.|||||| ..|| |. ||.. . ..| . ..  . |. . 
iEDrrseakll..esngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekale
PPM_PTC7_SpoIIE_motif 297-351 2.9e-06 20.9 In-house 15-80 (81) alignment 
Range on Protein: 297-351
Range on HMM: 15-80/81.0
MILASDGLW-------DAFSNEEAVRFIKERldE---PHFGAKSIVLQSFYRG---CPDNITVMVVKF
..|..|||.       . |..||..|.....  |   .   |. .| .   .|   . |.||..|...
llLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlrv
SpoIIE Stage II sporulation protein E (SpoIIE) 126-320 9.9e-06 17.5 Pfam-A 9-149 (193) alignment 
Range on Protein: 126-320
Range on HMM: 9-149/193.0
IFDGHGGETAAEYVKSRLPEALKQHLQDYEKdkensvlsyqtiLEQQILSIDREMLEKLTVSydEAGTTCLIAL--LSDKDLTVANVGDSRGVLCDKDGn
. |. |   .|  . ..| .||.. ...  .            ... .  ... . ..|. .  | ..|...|   .|.. |..||.|..  .|...|| 
vgDvvGhGleAalimgllrsalrelatagle............paevlerlnealarnleee..erfatavlaeydpstgkleyanaGhpppllvrpdg.

aiplshdhkpyqlKE---------------RkrikraggfisfngswrvqgilamsrslgdyplknlnvviPDPDILTFDLDKlqPEFMILASDGLWDAF
             ..                                                         |..  ...|..   . ..|..||. .| 
.............gtkfllvstglplGilpe........................................adyeeaelqlep..gdllllyTDGvtEar

sNEEAVRFIKER
 ...   | |||
.dpdgelfgker
SpoIIE Stage II sporulation protein E (SpoIIE) 126-320 9.9e-06 17.5 In-house 9-149 (193) alignment 
Range on Protein: 126-320
Range on HMM: 9-149/193.0
IFDGHGGETAAEYVKSRLPEALKQHLQDYEKdkensvlsyqtiLEQQILSIDREMLEKLTVSydEAGTTCLIAL--LSDKDLTVANVGDSRGVLCDKDGn
. |. |   .|  . ..| .||.. ...  .            ... .  ... . ..|. .  | ..|...|   .|.. |..||.|..  .|...|| 
vgDvvGhGleAalimgllrsalrelatagle............paevlerlnealarnleee..erfatavlaeydpstgkleyanaGhpppllvrpdg.

aiplshdhkpyqlKE---------------RkrikraggfisfngswrvqgilamsrslgdyplknlnvviPDPDILTFDLDKlqPEFMILASDGLWDAF
             ..                                                         |..  ...|..   . ..|..||. .| 
.............gtkfllvstglplGilpe........................................adyeeaelqlep..gdllllyTDGvtEar

sNEEAVRFIKER
 ...   | |||
.dpdgelfgker