Gene PPP1C-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP096_AA protein Get Run
MbreP096_AA_2-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 19-298 1.7e-163 535.5 In-house 2-281 (282) alignment 
Range on Protein: 19-298
Range on HMM: 2-281/282.0
SRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
|..||.|.|.||||. |. |.|||.|.||||||||||..|.|| ||||.||||.||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDR
|||||.|||||||||||||||||.|||||||||.|||||.|||.||||.|.||||||.|.|.||||.|.||..||..||||||||.||.|...||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADK
|||||||..||||||.|.|.|||.||||||||||||||||||||.|||||||||||||||..||||.|..||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 4-298 4e-139 456.2 In-house 1-296 (300) alignment 
Range on Protein: 4-298
Range on HMM: 1-296/300.0
VDVDKIISKLLEVR-GSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETIC
||.|.|| |||.    ..  | | | ..||  .|.|.||.||.|| ||||  ...| || |||| ||||.|   |||| .||||||||||||||||||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL
|||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||.||..  |||| |||||| |.||..||...||||||| ||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADK
|.||   |  | .|.||||. .    ..||| |  .||.|||| |||||||||  | |||.|||||||||||| ||.||| | |.|||..| | | 
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-299 7.4e-139 454.8 In-house 2-297 (298) alignment 
Range on Protein: 5-299
Range on HMM: 2-297/298.0
DVDKIISKLLEVRGSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||......|.|  |    |  ..|...  |. ....|| .|. |.|..||...||| |||| ||||.|. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||| ...|...| | || ||..||| ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKK
||||.  .|| || ||||..|| .||...|.| |.||..|||||| |||||||...||||||||.|||.|||. |.|.||| |..||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 4-301 8e-131 428.7 In-house 1-299 (299) alignment 
Range on Protein: 4-301
Range on HMM: 1-299/299.0
VDVDKIISKLLEVRGSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICL
.|||...||||.|  |    |  . | |.. ||  ....|..|. |||.|||...||| |||| ||||.|.  ||||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL
||..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. ||  .|.| |||||| ||...|.| . || | |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKKTK
||||..   .|  | ||||. ||..||.. ... |.||..||||||.|||||||...|||||||| |||.|||. |.| ||| |.|.|..|||..|. |
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 27-298 1.2e-122 401.4 In-house 6-277 (280) alignment 
Range on Protein: 27-298
Range on HMM: 6-277/280.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. ||.| ..  | ..|.. |  ..|..||...||| |||| ||||.|.  .|||..||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFGP
||| |||.||.||||. .|.. | . .. ||..||.  .|.| |||||..|.|........|| | .|  |  ||||||||.. |||.|| ||||  || 
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

EVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADK
.|| .. .| |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||| |. ||..|||| .
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
0045823 Metallo-dependent phosphatases 19-299 4.2e-118 387.9 In-house 35-327 (473) alignment 
Range on Protein: 19-299
Range on HMM: 35-327/473.0
SRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
..  |   |.| ... |. . .||. ..| ||||.... ..|| |||..||||..|  ||||| ...||||.|||| .|||...||||.|||||.|.|||
ehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPeKDSTG------
|||||.. .| .|||.||. ..|...|.. | .....||.||.|..||...||||||||....|||.| || ..|| |||.||||.||  .  |      
rGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrl

--WGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQ------LVTIFSAPNYCGEFDNAGAMMSVDESLmCSFQILKPADKK
  .| . ||....|||..||.||.|...|||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .|| | .||....|.. .
rffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp
PP2Ac_SM00156 28-296 2.6e-117 383.7 In-house 2-270 (271) alignment 
Range on Protein: 28-296
Range on HMM: 2-270/271.0
TEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. |.. |. ...||. ... |.|..||. ..||.|||..||||..| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFGPE
|.||||..|.||.|. .... |...|..||.|||.|.||.| ||||||.|.|...||.. |. . |. |||.||||.|||..  |.  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
.|..||.|....||.|||.||..||||||...|||||||||||.||.|..|...|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0049330 Metallo-dependent phosphatases 3-300 2.3e-116 381.1 In-house 6-303 (309) alignment 
Range on Protein: 3-300
Range on HMM: 6-303/309.0
SVDVDKIISKLLEVRGSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETIC
.......| .||..  ... |.. |.| |.. |. | .||....|.||||.... ..|| |||..||||..|  ||||| ...||||.|||| .|||...
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL
||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||.|..||.|.||||||||....|||...||...|..|||||||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdll

WADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKKT
|.||  .  |...|.||....||. .||.||.|...|||.|.|..|..||..|....|.|.||||||||...|.||.. .||.|..||....|.. ..
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
PPP_1 28-282 2.1e-115 377.5 In-house 2-264 (264) alignment 
Range on Protein: 28-282
Range on HMM: 2-264/264.0
TEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ....|||..... .|||.|||..|||..|..||..||.|||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL-------WADPEKDSTGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||||||||...||||||.|....|||...| |.||..| |||||       . |........ ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSV
....||..|.||||.|....||.|||.|.|.||||..||..||||||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 27-294 2.6e-114 373.8 In-house 2-270 (271) alignment 
Range on Protein: 27-294
Range on HMM: 2-270/271.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.| |.. |. | .||. ....|.|..||. .|||.|||..|||..|..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.|||||||....||||||...|..||... |...||..|.|.|||. ..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILK
|.|.|.||.|....||.|||...|.|||.......||.|||||||....||||.....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 27-295 1.1e-111 365.9 In-house 8-282 (284) alignment 
Range on Protein: 27-295
Range on HMM: 8-282/284.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| |.  ||...||.| .... ||.|||..|.|| |||. ||| ...  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| |||||.. .|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKP
  .||.. |..||.|...||. |||||| ||||||| |.|||||||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 31-299 1.1e-107 352.8 In-house 7-277 (284) alignment 
Range on Protein: 31-299
Range on HMM: 7-277/284.0
EIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
..  | ... .|| .||.|.| ..|. |||| |||. ||||.|.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYNI-KLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTG-LLCDLLWADPEKDSTGWGENDRGVSFTFGPEV
||||.||.||||   ....|   |  .|..||. ..|.| |||.|  || . |.| | || | |.   |  |.||.|| .   ||  | ||||. || . 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKK
. |.| . ..||. ||||||.|||||||.|.|||||||| |||.|||| |.| |.. |.||| .|.|  | 
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 6-296 2.5e-106 348.3 In-house 2-295 (297) alignment 
Range on Protein: 6-296
Range on HMM: 2-295/297.0
VDKIISKLLEVRGSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
||.||  .|         .  .||  .  |   . ..| .|  ..|..||...||| |||. ||||.|  ||.|| .||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDTGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. || .||.| ||||||   .  ... .|.| |.|.    .|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
|||||    .|. ||.||    || . | |   . ..||.|||||||.||||||| |.|||||||| |||.|||. |.||.|| | |||.||.|.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 9-295 1.1e-105 346.1 In-house 4-290 (293) alignment 
Range on Protein: 9-295
Range on HMM: 4-290/293.0
IISKLLEVRGSRPGKTVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYK
.|  ||..  ..  ... |.| |.. |. . .||....|.||||.... ..|| ||...|||...|. |||||....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPE
..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||||..||...|||||||| ...|||.|.||...|..|||.|||| || 
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKP
 . .||. . ||....||. .|..||.|...|||.|.|||| |||... ...|||.||||||.|...|.||.. .||.|...|....|
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP4C_pd Subfamily PPP4C 26-296 8.4e-104 339.8 In-house 15-285 (288) alignment 
Range on Protein: 26-296
Range on HMM: 15-285/288.0
DLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ..| |.. || |.|||....  . ....|  .||| |||.||||..|. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEkDSTGWGENDRGVSFTF
.| ..||||||| |.| ....|.  |. |. |..||.||.|||| ||||||.......|| | | ..||. | ||||||.||| | .||.   ||  . |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylf

GPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
| .|||.| .. |..|||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. |
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP2C_pd Subfamily PPP2C 24-299 8.6e-103 336.5 In-house 14-289 (290) alignment 
Range on Protein: 24-299
Range on HMM: 14-289/290.0
TVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.  |.|.|.. || | .||. ..  . |...|. .||| |||..||| .|  ||  |..||||||||||||  |.||..|| | |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEkDSTGWGENDRGVSF
   | ..||||||| |.| | ..|| ||| |..||..||.||.||| |||||| ......|| . |  .||. | ||||||.||. | .|||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKK
||| .. ||| .. .. || ||||.| .||..  .|..||||||||||    | .|.. .|..|  ||   .|| ..
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 25-297 8.3e-100 326.6 In-house 6-278 (281) alignment 
Range on Protein: 25-297
Range on HMM: 6-278/281.0
VDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
|..|. ||  .  . . || ..  | |...|  . || |.|. || |.||  | .||  ..|||||||||.||||.. ||...||.|... .||||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

ASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTF
||.|.||||| ||. .| ..||  |  ||| ||..|||.... | ||||||.| .....| . .| . .| ||. |||||||.... .| .  ||.||||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPAD
| .||..   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. |||.|  |.. | || 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 82-296 1e-98 323.5 In-house 101-315 (317) alignment 
Range on Protein: 82-296
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| ||||... .|. |  || .. ||.. |..||.|.|.||. |||||||||||||| |.||||||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDESLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 26-299 2e-97 318.6 In-house 9-285 (287) alignment 
Range on Protein: 26-299
Range on HMM: 9-285/287.0
DLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ... .|  .  | .||.   | |||.|||. |.||.|||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||. 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDT--GLLCDLLWADPEKDSTGWGEND-RGVSF
 ||..|||..| ||... .|.|.| | |. ||. | ....|.| |||.||.|.|..... . .||   .   ||  ||||||||||. .   |  |..| 
kinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

TFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKK
 || ..|...|.| |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |..||  ||  ||| | .
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfe
subfamily_PPP6C_pd Subfamily PPP6C 26-294 5.9e-93 304.2 In-house 14-282 (290) alignment 
Range on Protein: 26-294
Range on HMM: 14-282/290.0
DLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|.... || .  ...|..  .  ...|. .||| |||.|||. .|  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEkDSTGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |..||.|||...| |||||||.. ..||| | | ...|  | .|||.|.||| |   |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILK
| .|...|.|  ...|||||||.||.|.... . .|||..||||||    |  ........   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 28-296 2e-88 289.5 In-house 7-275 (280) alignment 
Range on Protein: 28-296
Range on HMM: 7-275/280.0
TEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
|  ||  .      ||...  | | |||... || | || |. |.|.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFGPE
|.||||| ||. .| . ||  |  ||| .|...|| ....| ||||||.|  .. || | || .  | ||| ||||.|| .   ||  . ||.|. ||  
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkg

VVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
|||.  .  ..||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
vveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPP3C_pd Subfamily PPP3C 27-287 1e-87 287.8 In-house 41-314 (452) alignment 
Range on Protein: 27-287
Range on HMM: 41-314/452.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.|...  .  .. ... ... |||.|||. ..|| |||.||||..|| || | ...|||||||||||  |.|..  |.| ||.||...|||||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDST------GWGEN-DRG
.   . | .||| .|. .........|..||.|||.... .|.||||||...|...|... |  ..| .|.||||||.|| .|         . .|  ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAK------RQLVTIFSAPNYCGEFDNAGAMMSVDESLM
 |. .. . | .||.| |.  | |||.. ..||. . |        |.|.||||||.. ..| .|.. ...  |
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPG1_pd Subfamily PPG1 27-296 5.2e-87 284.9 In-house 14-296 (300) alignment 
Range on Protein: 27-296
Range on HMM: 14-296/300.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
| |. .. |. | .|.....  . |...|. . || |||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRIYGFYDECKRRY--NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPE---------KDSTG--W
| ..|||| || |.|  | ..|| .|. |. | .||.|||.|.| ||||||. .|..||. . |  .||. | |.||||.|||          |  |  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
 . .||  ...| .||||||.. ||. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . |
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea
subfamily_PPP5C_pd Subfamily PPP5C 37-285 1e-85 280.6 In-house 44-298 (322) alignment 
Range on Protein: 37-285
Range on HMM: 44-298/322.0
VKSREIFLNQPILLELEAP----LRICGDTHGQYYDLLRMFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIY
....|.. ..| |.|.. .    | .|||.|||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKdSTGWGENDRGVSFTFGPEVVE
|| .|.| .|. |. . ||. || ||.| .|.||.. .|||| | |  .....|.| | .. |. |||..|||.||.. ..| ..  |||...|||.| .
GfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtk

KFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSV-DES
|||.. ...|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... .. 
kflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 24-296 3.4e-85 278.6 In-house 13-289 (290) alignment 
Range on Protein: 24-296
Range on HMM: 13-289/290.0
TVDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.  ... .|  .  | .||.   | |||.|||. | || |||  .|||.|.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDTGLLCDLLWADPEK--DSTGWGENDRG
.  .||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....| | .. . .|      | ||  |||||||..  | |   .  |.
vrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

VSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPA
.|  || ......|.|  ..|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |||  |. .||| 
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
PPP_2 57-247 1.1e-82 269.6 In-house 2-197 (198) alignment 
Range on Protein: 57-247
Range on HMM: 2-197/198.0
RICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFNC
..|||.|||..|||..|..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL----WADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQV
||.|||||||....|||||.......||... |....|..|.|.|||    . ||....... .. ||....|||.|.|..|.|....||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 57-247 5.4e-80 261.1 In-house 2-196 (197) alignment 
Range on Protein: 57-247
Range on HMM: 2-196/197.0
RICGDTHGQYYDL-LRMFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFN
 ..||.|||..|| |.....||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DTGLLCDL-LWADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQV
.||.|||||||....|||||..|.|...|.|| |....| . ....|| ||.||... .|. .. ||....|||.|.||||.|....||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-299 4.1e-77 252.6 In-house 121-337 (339) alignment 
Range on Protein: 83-299
Range on HMM: 121-337/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.|.. |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || ||||.    |.    || || |||  .  ||.| |.... | |||||||||||  |.||||||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DESLMCSFQILKPADKK
|. |  | ....|  . 
dkklkisinvfrpesrd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 49-299 1.3e-76 250.8 In-house 2-259 (263) alignment 
Range on Protein: 49-299
Range on HMM: 2-259/263.0
LLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||. ||||||||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDT-GLLCDLLWADPEKDSTGWGEND-RGVSFTFGPEVVEKFLHKHDMDLI
 ... | . |. .|..|.. ..|.| |||.|| |.|...|| |  | .   |  | |||||||||||. |.  |  | .|  || . |. . .. |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKK
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| | .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfe
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-295 1.8e-76 250.3 In-house 18-291 (307) alignment 
Range on Protein: 25-295
Range on HMM: 18-291/307.0
VDLTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
.. |  |.  .  ... ||  .  |.... |  . || |||. ||. ||   | |||. |.| |||||||  |||.| ||..||| ||||  ||||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

ASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWADPEKDSTGWGENDRGVS
| .|. ||||.||     .   ..|  |  ||| ||..|||  ||.| |||||| |  ....|   .|   |  |.. |.|||||.     |    ||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

FTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKP
|||| .|..   ..  ..|| ||||.. |||  .. |.|.|||||| ||  . |||... |||.|      . |
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp
PPP_5_Dcr2 58-248 4.3e-76 248.3 In-house 3-199 (199) alignment 
Range on Protein: 58-248
Range on HMM: 3-199/199.0
ICGDTHGQYYDL-LRMFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDCFN
.|||.|||..|| |..|. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|.
vcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvfd

CLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DTGLLCDL-LWADPEKDSTG-WGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVV
.||.|||||||....||||||...|.|....| |....| ..|  .|| ||.||... .| . .. ||....|||.|.||||.|....||.|.|...
wlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 27-295 4.7e-69 225.9 In-house 6-299 (302) alignment 
Range on Protein: 27-295
Range on HMM: 6-299/302.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
... |.  |. .  | . ..  | |. .|. | || |||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDTGLLCDLLWADPEK-
. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.|||. |||.| |||.|| |.|.|.|..| || ..| .  |  |||.|||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

-------DSTGWGEN-DRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKP
       .   . .|  ||.|..|    |... .. ...|| ||||..  |. |||...|.||||||.|  | || ||.. ||     | ..|..
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-294 1.1e-68 224.7 In-house 7-299 (302) alignment 
Range on Protein: 27-294
Range on HMM: 7-299/302.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
... |.  |. .  | . ..  | |. .|. | || |||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDTGLLCDLLWADPEK-
. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.|||. |||.| |||.|| |.|.|.|..| || ..| .  |  |||.|||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

-------DSTGWGEN-DRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILK
       .   . .|  ||.|..|    |... .. ...|| ||||..  |. |||...|.||||||.|  | || ||.. ||     | ..|.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 34-287 3.8e-58 190.1 In-house 4-280 (290) alignment 
Range on Protein: 34-287
Range on HMM: 4-280/290.0
GLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLR----MFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . || ||.| ||      ..  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIKL---WKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDTGLLCDLLWADPEKD-----------S
 . .. |.. ..  .|   |..|...|. ||.|| ||.|.||.|.|.    ..  .|   . |.   . |.  . |  |.||.||..|           .
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

TGWGEND-RGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAgAMMSVDESLM
 |. .|| || .  |. . .|.||.. ... . |||.| | |...  | .|.|.||. .|||  ..| |.. ||.. .
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkkl
Metallophos Calcineurin-like phosphoesterase 58-247 1.3e-45 149.1 Pfam-A 5-198 (200) alignment 
Range on Protein: 58-247
Range on HMM: 5-198/200.0
ICGDTHGQYYDL----LRMFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-------------
..||.||...||    |.... .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.              
vigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeey

---------------------RRYNIKLWKTFTDCFNCLPVAALIDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdtgllcdllwadpekdstgwgend
                      ... . .  . ..|..|| .||.| ||...||.||....| ..|                                  
enlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..................................

rgVSFTFGPEVVEKFLHKHDMDLICRAHQV
   |. |||...||.| |...||..|.|. 
..gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 56-188 5.7e-38 123.6 In-house 66-201 (383) alignment 
Range on Protein: 56-188
Range on HMM: 66-201/383.0
LRICGDTHGQYYDLLRMFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKLWKTFTD
. .||| ||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAALIDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|.||||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 198-303 2.3e-22 72.3 In-house 237-341 (383) alignment 
Range on Protein: 198-303
Range on HMM: 237-341/383.0
LCDLLWADPEKDSTGWGENDRGVSFTFGPEVVEKFLHKHDMDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPAd
. |.||.||....  . .  ||    |||.| .|.|.|....|. |.|.   .||||  .....||||| ||  |  | || . . ..|.  .   . . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas.

KKTKYS
|.|| .
katkkl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 27-80 2.6e-16 52.7 In-house 9-62 (317) alignment 
Range on Protein: 27-80
Range on HMM: 9-62/317.0
LTEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPP
..|.|.  || ..||.| ..|. ||||||. |.|| |||. ||| ...  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 28-81 3.2e-12 39.2 In-house 12-65 (339) alignment 
Range on Protein: 28-81
Range on HMM: 12-65/339.0
TEAEIRGLCVKSREIFLNQPILLELEAPLRICGDTHGQYYDLLRMFEYGGFPPE
  ||.  || ..||.   .||.|.||||. . || |||. ||| |..  |.|  
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 57-159 3.1e-07 23.1 In-house 13-121 (235) alignment 
Range on Protein: 57-159
Range on HMM: 13-121/235.0
RICGDTHGQYYDLLRMFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRYNIKLWKTFTDCFN
 . || || | .|.....   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .    ..|.. |.
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

CLP---------------VA
 |.                .
flesklskadmeyarelgfs