Gene PPP1C-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP098_AA protein Get Run
MbreP098_AA_494-806 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 493-807 3e-117 383.8 In-house 5-281 (282) alignment 
Range on Protein: 493-807
Range on HMM: 5-281/282.0
DKFTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPER
.| . .| ||.||||..|...|......|.. ||||..||||||.||||..|.|.|.|...       .|||.||.|||||.|||...|||..|..|||.
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes.......nylflGdyvdrGkqsletivlllaykikypen

VFLVRGNHEDGDVNAYFGFKDECLGRLGPTnghtIWERMNKVFGWLPLAALVDEKILCVHGGigkaslprvckgkgkgspvLNSEFTSVQQLRDIQRPLP
.||.|||||. ..|...||.|||  |.. .    .|.....||..|||||||||||||||||                   |..|..|..|.|.||||| 
lfllrGnhesasinriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGG...................lspelksleqirkiqrPle

QPMTssyaAILRDVLWADPtDNDySLGIHANTiRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTIN
.|..    ..|.|.||.|| |.. .||...|. ||... .||.|.||.|||.|.|..||||||.| .|||||||.||.|||||.||||...|.||.|...
vpek....gllcdllWsdp.dke.vlgwsend.rGvsf.tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvd

RELAVAFSVIRPGDM
.||.|.|....| ..
eellvsfqilkpakk
0045823 Metallo-dependent phosphatases 495-806 9.9e-86 281.2 In-house 40-325 (473) alignment 
Range on Protein: 495-806
Range on HMM: 40-325/473.0
FTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHhTgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVF
. |... .|  || .|   ||. ...|.. ... |.|||||||.|||  ..  | |.  .       ..| ||.|||| .||||. |||.||..||..||
egllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppe.d......rlvflGDlvDrGpdslevlelllalkikypgnvf

LVRGNHEDGDVNAYFGFKDECLGRLGPTnghtIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgkgkgspvlnsEFTSVQQLRDIQRPLPQP
|.|||||.  .|...||.||.| ..|      ..|...... .|||||....|||.||||.                     ......|.| |.|||  |
llrGNHElrllnglygfgdetlekyged....lyeeflewlrslPlaaviggkilfvHGGlsp...................dlplldqireierpleip

MtssyAAILRDVLWADPtDNDYSLGI-----HANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQ------LITVFSATNYCGRYG
       .| | ||.|| ..|   |.       |. ||   . |||| ||.||..|.|..|||.|..|  |||.. . .      .||||||.|||||.|
d....dgllldllwsdP.weddgdgllrlrffgnsprgagyl.FgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrgg

NDGAMLTINRELaVAFSVIRPGD
| .|.|.|. .| . | ...| .
nlaAvlvidedl.isfiqfdpsp
PPP_3 499-802 3.1e-85 278.5 In-house 3-269 (271) alignment 
Range on Protein: 499-802
Range on HMM: 3-269/271.0
KFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHhtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRG
.  ||. |. ...  |.. |..... |||.|.||||||| |||..|.. |....        .||| ||.|||||.||||..|||.||..||..|.|.||
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspe.......tkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRG

NHEDGDVNAYFGFKDECLgrlGPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKAS-LPRVCKGKGKGSPVLNSEFTSVQQlrdiqrplpqpmts
|||. ..|...|||.|.|     ..|.........|| .||||||.|||.|.||||. ..  .    | . .   | ... .  ..              
nhEsrqinkvYgFkkevl...kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll..............

syaailrdvlWADPTDNDyslGIHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAV
          . ......   .  .|. ||  .  |||| .|.||..|.|..|.|||... .|||........|||||.|||.|..| ||.|.....|  
..........lssdpeke...eglenskrGagl.lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealts

AFSVI
 | ..
efkql
PP2Ac_SM00156 502-804 1.6e-84 276.1 In-house 5-269 (271) alignment 
Range on Protein: 502-804
Range on HMM: 5-269/271.0
ELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFdtygspnHHTGDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHE
|. .||  ... |||......| ||| |.||||||| ||| ..       . .|  .   |.| ||.||||..|.||..||..||..|||.|.| |||||
evlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll.......elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHE

DGDVNAYFGFKDECLGRLgptnGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgkgkgspvlnsEFTSVQQLRDIQRplpqPMTSSYAA
. .|| ..||..|.  .     |. |.|.....| .||||||||.||||.|||. .                   | .|....| ..|    . ..    
sssvnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlsp...................eleslddirklkr....vkekpeeg

ILRDVLWADPtdNDYSLGIHANTiRGSeICNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSV
.| |.||.||  ..   |..... ||  .. ||.|.|..||..|||..|.|||..|  ||||||...|.|.|||.|||....| .|.|... .|   . .
llidllwsdp..eqkekgfqpsk.rgl.svvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieq

IRP
...
lke
0049330 Metallo-dependent phosphatases 495-806 4.8e-79 258.7 In-house 27-300 (309) alignment 
Range on Protein: 495-806
Range on HMM: 27-300/309.0
FTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPnhhtgdiHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVF
. |... ||  ||  | . ||. ...|.. ... |.||||||| |||  .. .| |        .  ..| ||.|||| .||||..|||.|||.||..||
lkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp.......pedrlvflGDlvdrGpdslevlllllalkllypdnvf

LVRGNHEDGDVNAYFGFKDECLGRLGPTnghtIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgkgkgspvlnsEFTSVQQLRDIQRPLPQP
|.|||||.  .|...||.||.| ..|.     .||...... .|||||....||||||||.                     ......|.|...|||  |
llrGNHElrllnglygfgdetlrkygae....lweefldwlrslplaaviggkilcvHgGlsp...................dlllldqirelerpleip

MTSsyaaILRDVLWADPTDNDYSlgIHANTiRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRE
...    .| | ||.||..  .   .. |. ||   . ||.. |||||. |.|..|.|.|..|  ||..|....|||||||.|||||.|| ||.|.|. .
ldg....llcdllwsdplpireg..fapnp.rglg.vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleided

LAVAFSVIRPGD
| . | ...| .
lvisfllfepvp
PPP_1 502-790 1.2e-78 257.1 In-house 5-263 (264) alignment 
Range on Protein: 502-790
Range on HMM: 5-263/264.0
ELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHE
|| .|.  ... |......|.| ....| ||||||. |||..| . |.....       .|||.||.|||||.|.|...|||.|||.||...||.|||||
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspet.......nYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHE

DGDVNAYFGFKDECLgrlGPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKAsLPRVCKGKGKGSPVLNSEFTSVQQLRDIQrplpqpmtssyaa
.  |. ..|||.|.|     . ...|.. . .|| .||||||.|||||.||||. .  |  . . . . .    .| . ...|.. .             
srqvtkvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspe.ldlldqirkerrktevpeegklcdllekd.............

ilRDVLWADPTDNDyslGIHANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLT
   | |. |.....   .  ||.|||   . ||.| .|.|||.|||..|.|||... .||||..|....|.|||.||. . .| ||...
..vdillsddkeqe...eavansiRGag.ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 493-806 1.7e-78 256.7 In-house 19-295 (298) alignment 
Range on Protein: 493-806
Range on HMM: 19-295/298.0
DKFTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPER
   . || ...| |.. |.  .|. .....| ||.|| |||||| .||| .||  | |...        |||.||.||||...|||..|||. |..||..
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppda.......nylflGdyvdrGrqnlevivlllaykvkypnn

VFLVRGNHEDGDVNAYFGFKDECLGRLGPTNghtIWERMNKVFGWLPLAALVDEKILCVHGGIGKASLprvckgkgkgspvlnseftSVQQLRDIQRPLP
.||.|||||   .|  .||..||  |   ..   ... ...|| .|||.||. ..|||.|||. |                      |..|||...||  
ffllrGnheceainrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskklk...................sldqlrelkrpfd

QPMTssyaAILRDVLWADPTDNdySLGIHANTiRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTIN
.. .    ..  |.|||||...    | ..|. ||   . || |.|. .|.. .. ..||||| |  ||||||...|.|.||| .|||.. |  |.....
skee....slaidllwadpena..vkgwaens.rGvs.vvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvd

RELAVAFSVIRPGD
 .| |.| |..| .
eklvvsfevlkpek
0053225 Metallo-dependent phosphatases 495-802 4.5e-71 232.7 In-house 19-288 (293) alignment 
Range on Protein: 495-802
Range on HMM: 19-288/293.0
FTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPnhhtgdiHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVF
. |... ||  ||  | . ||. ...|.. ... |.|||||.|.|||  .. .| |       ..  ..| ||.|||| .||||..|||.|||.||..|.
lkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp.......pedrlvflGDlvdrGpdslevlelllalkllypdnvv

LVRGNHEDGDVNAYFGFKDECLGRLGptnGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKASLprvckgkgkgspvlnseftSVQQLRDIQRPLPQP
|.|||||.  .|...||.||.| ..|   .  .|....... .||||||...|||.||||.                        ...|.|.|.|||  |
llrGNHElmllnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdls...................lldqireinrplrip

mtssYAAILRDVLWADPTdndYSLGIHANtIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRE
    .  .| | || ||.   .  |.. . .||   . ||.. |.|||. |.|..|.|.||.|  ||... ...|.|||||.||.||.|| ||.|... .
....legllldllwsdpd...lwsgwlps.yrglg.vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg

LAVAFSVI
| . | ..
lvwgfklf
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 497-804 8.3e-70 228.4 In-house 7-282 (284) alignment 
Range on Protein: 497-804
Range on HMM: 7-282/284.0
LIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHTgDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLV
|.|  ||  |   |  .. ...  |.. ||||. ||||||  |||...| .| |  .  . .   |||.||.|||| ||.||.|||...||..|..|||.
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfved.eakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHEDGDVNAYFGFKDECLGRLGptngHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgkgkgspvlnsEFTSVQQLRDIQRPLPQPmt
|||||   ||  .||  ||  |      ....| ..  |  .||.|.|..||.|.|||| .                   .. ...|| ...||.  |  
rgnhesrpvnmqygfyleckkrys....ealyeafqlafnamplcavvskkiicmhggise...................dlldlkqldklerpidip..

ssYAAILRDVLWADPtdnDYSLGIHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELA
     .. |. ||||   . ..  .... ||.    ||.. |..||.. .|...||||| |. |||||| ..|.|.|||  |||.. | .|.|....|| 
..digviadltwadp...eaevegykesprgagk.vfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelv

VAFSVIRP
..|.|..|
asftvlkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 503-807 1.6e-68 223.7 In-house 15-284 (287) alignment 
Range on Protein: 503-807
Range on HMM: 15-284/287.0
LEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHhtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHED
.  .|  .|  |.  ...|.| ||....||||||| ||| .|.  | . .       . |||.||.||||  ||||. ||..||..||..| |.||||| 
ilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapk.......vqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

GDVNAYFGFKDECLGRLGptngHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPvlnsEFTSVQQLRDIQRPlPQPMTSSyAAI
  .|  .|||.|   . .    . .... |.||  ||| | |...|||.||||               ||    .  |...|. ...|  .|..     .
kkinklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGi...............sp....klksldslkalkkp.ttplacd.egl

LRDVLWADPTDNdySLGIHANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVI
  |.|||||. .  . ... | ||.     ||  .|. .|.. ....|||||. .  ||.|.....|.|||||. |.|.  | ||...... | ..| |.
qvdllwadpekd..aktfelnkiraisvv.fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl

RPGDM
.| |.
kpedf
subfamily_PPP4C_pd Subfamily PPP4C 494-802 2.5e-67 220.1 In-house 12-282 (288) alignment 
Range on Protein: 494-802
Range on HMM: 12-282/288.0
KFTLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTygspnhhTGDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERV
.  |||  |..|| | |.  | ..| | .| .|| | ||||||. |||..|.        .||..  .|||.|||||||..|.| . |||.||.|||.|.
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkv.......ggdvpetnylflgdfvdrgfysvetfllllalkvrypdri

FLVRGNHEDGDVNAYFGFKDECLGRLGPTnghTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPvlnsEFTSVQQLRDIQRPLPQ
 |.|||||  ..   .|| |||| . | .   ..|.   .|| .|.|||..|.||.|||||.               ||    ........| |.|    
tlirgnhesrqitqvygfydeclrkygsa...nvwryctevfdylslaaiidgkifcvhggl...............sp....sistldeirsidrkqev

PMTssyaAILRDVLWADPTDNDyslgIHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINR
|       .| |.||.|| | .      | . ||.    || | ||.| ..|....|.|||| |. || .  .....||.|| ||| | ||  |.| .. 
phe....gplcdllwsdpedae....gwavsprgagy.lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailelde

ELAVAFSVI
||   |...
eldkdfkif
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 498-805 4.9e-65 212.4 In-house 6-275 (280) alignment 
Range on Protein: 498-805
Range on HMM: 6-275/280.0
IKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVR
|| |......   .  |. ..|...| |||.| ||.||| .||| .|.  . |  .        |||.||.||||.. |||. |||. |.|||.. ...|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdq.......nylflgdyvdrgrqqlevillllaykvrypnnflilr

GNHEDGDVNAYFGFKDECLGRlgptNGHTIWERMNKVFGWLPLAALVDEKILCVHGGigkaslprvckgkgkgspvLNSEFTSVQQLRDIQRPLpqpmTS
||||  ..|  .|||||.  |        ... .....  |||.|||  .|||.|||                   |  .. |...|....||.     |
gnhevisinrkygfkdevkrr....yslalynefqelldslplvalvsgrilcmhgg...................lsqklvslddlaelrrpf....ds

SYAAILRDVLWADPTDNDYslGIhANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAV
  ...  |.||||| ..    |  |.. ||  .  || ..|  . .  ....|.| || |  ||||||...|.||||| .|.| . |. |.| .. .| |
edeclamdllwadpenkvt..gw.aensrgvsv.ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderliv

AFSVIRPG
.| |..| 
sfevlkpa
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 497-806 2.2e-64 210.5 In-house 23-295 (299) alignment 
Range on Protein: 497-806
Range on HMM: 23-295/299.0
LIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHhtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLV
 .|  ||  | | | ... .....|.| ||..| |||||| .||| .||  | | .         .||.||.||||.  ||..||||| |..|||| |..
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppd.......vnflflgdyvdrgrqnlelitlllcfkikyperffml

RGNHEDGDVNAYFGFKDECLGRLGPTnghTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLnsefTSVQQLRDIQRPLPQPMT
|||||   .|  .|| .||  |   |    .|  ... | ..||. |.  .|||.|||.               || |    ....||||..||   |  
rgnhecpainrvygfyeecnkrykst...rlwsifqdafaampltgligsrilcmhggl...............spkl....qtldqlrdltrpqdppnp

SsyaaILRDVLWADPtdNDYSLGIHANTiRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELA
|    .  |.|||||  ...  . .||. ||     ||.| |.  ..  ..... |||| |  ||||||...|.|.|||  |||.. |  |.. .. .| 
s....lgidllwadp..dqsvkdwlanv.rgvsyv.fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlv

VAFSVIRPGD
..| |..| .
ctfvvlkptp
subfamily_PPP2C_pd Subfamily PPP2C 500-804 1.3e-62 204.7 In-house 19-285 (290) alignment 
Range on Protein: 500-804
Range on HMM: 19-285/290.0
FAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNhHTgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGN
 .|...|   |.  |...| | .| .|| | ||.|||. ||| .|   |.   .|       |||.||.|||| .|.| .||| .||.||.||. ..|||
esevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggksp.dt......nylflgdyvdrgyysvetvtllvalkvrykeritilrgn

HEDGDVNAYFGFKDECLGRLGPTNghtIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLnsefTSVQQLRDIQRPLPQPMTssy
||  ..   .|| |||| . | .|   .|. . ..| .|||.|||||.|.|.|||.               || .    ......|...|    |     
hesrqitqvygfydeclrkygnan...vwkyftdlfdylpltalvdeqifclhggl...............spsi....dtldkiraldrlqevphe...

aAILRDVLWADPTDNDyslGiHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAF
   | |.||.|| | .   | .. . ||.   .|| |  |.| ..|.|..|.|||| |. ||..  .....|.||| ||| | || .|.| .. .|  .|
.gplcdllwsdpddrg...g.wgisprgagy.tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysf

SVIRP
    |
lqfdp
PPP_2 527-757 4.3e-62 202.3 In-house 1-198 (198) alignment 
Range on Protein: 527-757
Range on HMM: 1-198/198.0
VKVFGDIHGQLADLLTFFDTYGSPNHhtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLgrlGPTNGHT
|.|.||.|||| |||..|.. .....        .||| ||.|||||.||||..|||.|||.||..|.|.|||||. .||...|||.|.|     ..|..
vtvcGDlHGqldDLlilfknglpspe.......rkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl...kkkggkk

IWERMNKVFGWLPLAALVDEKILCVHGGIGKASLpRVCKGKGKGSPVLNSEFTSVQQLRDIQRplpqpmtssyaailrdvlWADPTDNDyslGIHANTIR
.......|| .||||||.|||.|.||||. ..    . . | . ...   | .....|   ..                  . ||....   .. ||. |
vykklqevfelLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeek..................lsdpkeke...ellansar

GSEIcNFGPDQVERFLQENNLQMIVRAHQCV
|  .  |||| .|..|..|.|..|.|||...
Gagl.lfgpdvteelleknklkliiRaHevk
subfamily_PPP3C_pd Subfamily PPP3C 503-793 5.4e-62 203.0 In-house 46-311 (452) alignment 
Range on Protein: 503-793
Range on HMM: 46-311/452.0
LEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGspnhhtgDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHED
   ..  | . ||...|.|.| ||. | ||||||  ||| .|.  |       | .  .|||.||.|||| ||.|..  |..||. ||...||.||||| 
alkiieeaakllkkektlleveaPitviGdihGqfydllklfevgG.......dPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

GDVNAYFGFKDECLGRlgptNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGkaslprvckgkgkgspvlnSEFTSVQQLRDIQRPLPQPMTssyaAI
  .  || ||.||  .    ....... . . |  ||||||.... ||||||..                   .| .|........|    |..      
rhlteyftfkeeckik....yseevydacmesfdslPlaallnqqflcvhGGls...................peikslddikkldrfkeppas....Gp

LRDVLWADPTDnDYSL-----GIHANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAK------QQLITVFSATNYCGRYGNDGAMLTI
| |.||.||.. ||.          |..||   . ..   | .|||.|.|  |.|||..  |||. . |        |||.|||.||.. | | .|.| .
lcdllWsdPle.dygeekteekfvpnsvrGcs.yfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlky

NR
. 
en
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 498-805 1.1e-61 201.8 In-house 3-274 (284) alignment 
Range on Protein: 498-805
Range on HMM: 3-274/284.0
IKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPnhhtgdiHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVR
|   ..|.||  | . ....  ...| .|... ||||||..||| .||  | |       |   |||.||.|||||  || . ||.. |. .|...|..|
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfp.......hranylflgdyvdrgkhcletilllfaykvifpnhffmlr

GNHEDGDVNAYFGFKDECLGRLgptNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKAslprvckgkgkgspvlnseFTSVQQLRDIQRPLPQPMTS
||||   .|  .|| .||  |    |  ...  .. ||  .||.||| ..|||.|||. |                    .  | ||| |.||. .|   
gnhecslinkiygfyeecqrry...nkpsvyvsfegvfsvmpltalvgqrilcmhggvskm...................lqnvsqlraikrpfdnpepn

SYAAilrDVLWADPTDndYSLGIHANTiRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAV
. |    |.||.|||.  .  |   |. ||     || | . ..|.  .....||||| |  ||||||...|.|.|||  |||.. |  |.. .|..| .
tlai...dilwsdptn..fqkgwnpns.rgvsy.vfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvc

AFSVIRPG
.| |.|| 
sfvvlrpr
subfamily_PPP7C_pd Subfamily PPP7C 525-796 3.4e-61 200.1 In-house 64-326 (383) alignment 
Range on Protein: 525-796
Range on HMM: 64-326/383.0
APVKVFGDIHGQLADLLTFFDTYGSPNHHTgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRLgPTNG
  | | ||.||.| |||  .   | | ..       .|.| |||||||| |.|.. .||.| | ||. |.| ||||||  .|. .||  |   .  ...|
kevtvcGdlhGklddlllilyknGlpseen......pyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikevesky.kvhg

HTIWERMNKVFGWLPLAALVDEKILCVHGGIGKA-SLPRVCK-GKGKGSPVLNSEFTSVQQLRDIQRPLPQPMTSSYAAILRDVLWADPTDNDyslGIHA
. | . ...|| |||||.|.||||| ||||| .  .|  . |  . |   ||..  .. ..    ..    ... .    . |.||.||  ..   | ..
kkilrlledvfawlplatlidekilivhGGisdktdlelldkiersklvsvlrpplkegeeaekekeessvkvdkeewrqvldilwsdpkake...Gckp

NTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELA
||.||.  . ||||  ...||  ||....|.|.|   ||||  .....|.|||.||     | || . ....| 
ntlrGgG.syfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdlt
PPP_4 527-757 7e-61 198.7 In-house 1-197 (197) alignment 
Range on Protein: 527-757
Range on HMM: 1-197/197.0
VKVFGDIHGQLADL-LTFFDTYGSPNHHtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRlgptNGH
| |.||||||| || | .... | |...       ||.|.||.|||||.||||..|||.|||.||..|.|.|||||. ..|...|||.|.| .    .|.
vtvvGDiHGqlddlllkllkngglpsee......rsyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....hgk

TIWERMNKVFGWLPLAALVDEKILCVHGGIGKASLpRvCKGKGKG-SPvLNSEFtSVQQLRDIQrplpqpmtssyaailrdvLWADPTDNDYSlgiHANT
.|......|| .||||||.|||.|.||||. .    .  . . .   .  .|.. . ....|..                  ||.||....      ||.
eilkklqdvfdllplaalidekvlvvhgglsdele.s.ldkierierk.iespl.eeekrkdll..................lwsdpreaqeg...lans

IRGSEICnFGPDQVERFLQENNLQMIVRAHQCV
.||  .. |||| .|.||..|||..|.|.|...
vrGagll.Fgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 505-805 7.2e-61 199.1 In-house 30-295 (297) alignment 
Range on Protein: 505-805
Range on HMM: 30-295/297.0
ALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNhhtgdihALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGD
 ||  |   .|.. ....| ||.|| ||||||. ||| .|   | |        .  |||.||.||||.||.| . |||. |...|  .||.|||||   
klldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpp.......tanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

VNAYFGFKDECLGRLGPTnghTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLNSEFTsVQQLRDIQRPlpqpmTSSYAAILR
||  .|| .||  |        ..  .. || ||||. |. .||||.|||.               ||.|  ||| .. ||.|.|.     |     .. 
vnkvygfyeecqkryqsv...rmyaafqdvfnwlpltgliatkilcmhggl...............splltkeft.ldtlrkiers.....tegkerlva

DVLWADPTDNdysLGIHANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVIRP
|.|||||      |    .  ||.  | || | | .   | .|....|||| |  |||||| ..|.|.|||  |||.. |  |... . .| ..| ..||
dllwadpisg...lsgfmenqrgag.cgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp

G
 
t
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 501-804 1.9e-60 197.6 In-house 9-299 (302) alignment 
Range on Protein: 501-804
Range on HMM: 9-299/302.0
AELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHTGD----IHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLV
 || .|.   . .||...|. .. .|| . ||||||  ||.  . .  | ..             ..|.||.||||. |.| ..|...||. ||..  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHEDGDVNAYFGFKDECLGRLGPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLnsefTSVQQLRDIQRPLPQPMT
|||||   .|  .||..|   |||...|. |||..|.|| ..|||||| ||||||||||               || |    .|......|.|||.. . 
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi...............spkl....esledikkikrplkevte

SSYAailRDVLWADPTDNDYSLGI------HANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLT
 | |   .|.|.|||.| .    .      . |..||  .. |    |. . .  ||..|||||| . .|. |||...|.|.|||..|     | ||.| 
dsla...qdllfadpldvqllaavsekPkyaknivrglsvv.fneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlk

INRELAVAFSVIRP
.. .  .. ||.|.
vdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 501-803 3.5e-60 196.7 In-house 10-299 (302) alignment 
Range on Protein: 501-803
Range on HMM: 10-299/302.0
AELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHTGD----IHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLV
 || .|.   . .||...|. .. .|| . ||||||  ||.  . .  | ..             ..|.||.||||. |.| ..|...||. ||..  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHEDGDVNAYFGFKDECLGRLGPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVlnseFTSVQQLRDIQRPLPQPMT
|||||   .|  .||..|   |||...|. |||..|.|| ..|||||| ||||||||||               ||     ..|......|.|||.. . 
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi...............spk....lesledikkikrplkevte

SSYAailRDVLWADPTDNDYSLGI------HANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLT
 | |   .|.|.|||.| .    .      . |..||  .. |    |. . .  ||..|||||| . .|. |||...|.|.|||..|     | ||.| 
dsla...qdllfadpldvqllaavsekPkyaknivrglsvv.fneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlk

INRELAVAFSVIR
.. .  .. ||.|
vdtngklsisvlr
PPP_5_Dcr2 527-757 4.6e-60 196.0 In-house 1-199 (199) alignment 
Range on Protein: 527-757
Range on HMM: 1-199/199.0
VKVFGDIHGQLADL-LTFFDTYGSPNHhtgdihALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRLgptNGH
| |.||.|||| || | .|.. | |..        .|.| ||.|||||.||||..|||.|||.||..|.|.|||||| ..|...||..|.| .    .|.
vtvcGDlHGqlddlllilfkeggdpse......erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky...hgk

TIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgK--GkgspvlnseftsVQQLRDIQRPLPQPMtssYAAILRDV-LWADPTdnDYSLGIHA
 |.. ...|| |||||||.|||.|.||||. .         .               ...|..|.|. . |.        .|  ||.||.  |   |. .
kiykilsdvfdwlPlaalidekvlvvhgglsp.........eiks............iellekierkieipe...ekgekadlllwsdpr..daqegckl

NTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCV
|..||  .. |||| .|.||..|||..|.|.|...
nseRGagll.fgpdvtekfleknnlkliirshelk
subfamily_PPP5C_pd Subfamily PPP5C 481-799 7.4e-60 195.6 In-house 18-303 (322) alignment 
Range on Protein: 481-799
Range on HMM: 18-303/322.0
PEYLHNLDDQVSDKFTLIKFAELeALLACAETALKQDSTVLNVLAP----VKVFGDIHGQLADLLTFFDTYGSPNHHTgdihalSYLFIGDFVDRGKFSL
 |....| ... .. .| |   | ..|. |.. ||. ......  .    . | ||||||  |||  |. .|.| ..       .||| ||||||| ||.
kefvkellelfkkqkklhkkyal.killeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseen......pylfnGdfvdrGsfsv

EVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRLgptnGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKaslprvckgkgkgspvlnS
||. .||..|| ||...|| |||||  ..|  .||..|.  .      ... . ...|| ||||| ...||.| ||||. .                  .
eviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky....tekvadlftevfnwlPlahvinekvlvvhGGlfs..................e

EFTSVQQLRDIQRPLPQPMTssyaAILRDVLWADPTDNDyslGIhANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSAT
.  ....|| |.|   .|      ..| ..||.|| ..    |. ... ||   ..||||  ..||.||||..|.|.|.    |||.  . .||||||| 
dgvtlddlrkidrnaqppee....gllvellwsdpqean...Gr.spskrGvg.vqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsap

NYCGRYGNDGAMLTI-NRELAVAF
||| . || ||..|. . .| . |
nycdqmgnkgafitlrgddlklkf
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 503-804 1.9e-59 194.0 In-house 21-288 (290) alignment 
Range on Protein: 503-804
Range on HMM: 21-288/290.0
LEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHhtgdihaLSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHED
.  .|  .|  |.   ..|.| ||. ..||||||| .|| .||  | | .       . .||.||.||||  ||||  ||.|.|.||...| |.||||| 
ileilekieeileplpalleveapivivgdihgqldallryfdavgyppk.......vkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

GDVNAYFGFKDECLGRlgptNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLNseftSVQQLRDIQRPLpQPmTSSYAAI
  ||  .|||.|   .     |  .| ....||  |.| | |..||||.||||               |. ..    | . |. ...|   | ..    .
rkvnrlygfkeelark....rgsrlwkqyqdvfaelslcarvgrkilcmhggi...............sqkie....sweslkalkkpr.vp.ltcdegl

LRDVLWADPTDnDYSLGIHANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVI
  |.||||||  | .  |  |  |.  .  || . .. .|..  |..|||||.    |..|  ...|.|||||  |.|.  | ||..|.   | . . |.
qvdllwadptr.dkddtialnkqraisvv.fgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl

RP
.|
kp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 501-804 4.8e-59 192.9 In-house 11-276 (281) alignment 
Range on Protein: 501-804
Range on HMM: 11-276/281.0
AELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNH
 |.|...  .|. . ..... .. .|..| ||.|.|  ||   |.  | . ..        ..|.||.||||. ||||. ||..||.||..|..|.||||
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpee.......vlvflgdyvdrgpqslevlillftlkiryrdrivllrgnh

EDGDVNAYFGFKDECLGrlgpTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPvlnsEFTSVQQLRDIqrplPQPMTSSYA
|   ||  .||  ||        |  .|  ... |  ||..||.....||.|||.               ||    |.|. ..||..    |.|. . . 
eiasvnkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGl...............sP....eltaldelrnr....pkpirnldr

AILRDVLWADPTDNDYSlgiHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFS
 .. |.|||||... .      ...|||    || . |.   .. ....|.|||| | .||| .. ..||||||. |||  | | .|.|... .| . . 
GlviDllwadpdnkvee...wkassrGssf.tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislv

VIRP
 . |
alvp
subfamily_PPZ_pd Subfamily PPZ 509-806 1.5e-58 191.7 In-house 36-295 (300) alignment 
Range on Protein: 509-806
Range on HMM: 36-295/300.0
CAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAY
 |   .  . ..|..  .||. ||.||| |||| .|   | |           |||.||.||||| ||| . |||| |..||| .||.|||||  .|   
karelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsa.......nylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv

FGFKDECLGRLgptNgHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLNSeftsVQQLRDIQRPLPQPMtssyAAILRDVLW
.|| |||  |    |   ||. .   |  |||||.|  ||.|||||.               ||||||    ....| . ||   |       .. |.||
ygfydeckrrc...n.ikiwktfvdtfntlplaaivagkifcvhggl...............spvlns....mdeirhvvrptdvpd....fglindllw

ADPTDNDYSlgiHANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVIRPGD
.||||.        .  ||   | .    ...||..  .....|||  |  |||||  . |.||||| |||| . | ||.....  | ..| .. | |
sdptdssne...wednergvsyc.ynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
subfamily_PPPLV_pd Subfamily PPPLV 508-794 3.4e-56 183.7 In-house 7-278 (290) alignment 
Range on Protein: 508-794
Range on HMM: 7-278/290.0
ACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYgspNHHTGDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNA
  |   | ..  .|.. .|. |.||.||.  ||  | . .        |.   |.||.||.||||.||.|... || ||. || .|.|.|||||   |  
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvl...wrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

YFGFKDECLGRLGPTNgHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslPRVCKGKGKGSPVLNSeFTSVQqlrdiqrplpQPMTSSYaaILRDVL
 . .| |.  . | .    .|| .|.|| .||||| .|.|..|||.||     ||  ..... |.. .     ..          ...  .   .  |.|
sieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagi.....praimtqayisaiqdi.lerlk..........ddidgap..laldil

WADPT-DNDYSL--------GIHANtIRGSEICNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRyGNDGAMLTINRE
|.||  |.| ||        |   |  |. . . |. | .|.||..|||. ..|||.   .|...  | .|.||||...|||   |. |.. ....
wsdpaedrdlslrgelvlneGfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 520-807 9.6e-50 162.7 In-house 2-258 (263) alignment 
Range on Protein: 520-807
Range on HMM: 2-258/263.0
VLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRL
.|.. ||... || |||  |||  |.. |.  .         |||.||.|||| .||||. ||. |||  | ...|.|||||   .|  .||. |   |.
llelqapinicgdthgqyndllrifnacgaatkt.......qylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrf

GPTNG-HTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLNseftSVQQLRDIQRPLPQPMTSSYAAilrDVLWADPTDNdySL
   .   ......|.|| ..||.|.| ..|||.||||               || |.    |....| |  ||    |   |.   |.|||||  .  . 
qreevyesvynhfnqvfsymplcaivskrilcmhggi...............sphlk....slddiraiplpletakthplac...dllwadpekd..ak

GIHANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVIRPGDM
|.  | ||      ||  .|. . .  ....|||||| |  || ||| ..|||||||. |     |  |.. .|. | ..|  ..| |.
gfepnkirais.nvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedf
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 502-804 2e-49 161.5 In-house 10-274 (280) alignment 
Range on Protein: 502-804
Range on HMM: 10-274/280.0
ELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSpnhhtgdIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHE
|. |..   |. . ..| . .  ||.|| |||| |  |.  .||  |        .     .|.||.||||   .||. ||.|||.|| .|..|.|||||
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligr.......vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

DGDVNAYFGFKDECLGRLGptngHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPvlnsEFTSVQQLRDIQRPLpQPMTssyAA
   ||  .||  ||  . |      .|  .. .|  .|...|. ...||.|||.               ||    |.  .. .|.| ||  .|.     .
tpsvnkiygfyvecqykyg....vglwwdfqscfnrmpmsgliskrvlcmhggl...............sp....elinldtirniprpc.epld...rg

ILRDVLWADPTDNDYSlgiHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSV
.| |.||.|||..         .|||     ||   ||.  .  ....|.|||| |  |||..| ..||||||  ||| .. |  |.. .| .| |.|  
llidllwsdptnkgeg...wfhsirgisy.mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq

IRP
. |
lip
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 561-805 2e-47 155.0 In-house 121-334 (339) alignment 
Range on Protein: 561-805
Range on HMM: 121-334/339.0
SYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRLGptngHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKasl
 |||.||.|||| ||.||. || .||| ||.|..|.|||||   ||. .||  |   |        ..| ....|  .|..|.... |.|.|||| .   
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd....aqlyecfqnmfnvfpfcavinntimcmhggise...

prvckgkgkgspvlnsEFTSVQQLRDIQRPLPQPMtssyAAILRDVLWADPTDNDYslGiHANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAG
                 .||..|.  ..|||  |       .| |. ||||   .   | .  . ||. .  |||  .  ||.. .|||..| || |  |
................hltsfnqfsvfkrpleipd....vgvltdltwadpdptek..g.ykpsargasfv.fgppalraflkkldlqmvirghqvvedg

YEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVAFSVIRPG
||||  ..|.|.||| ||||.  |  |...|...| ..  |.|| 
yeffdgrrlvtifsapnycgqndntaavfsidkklkisinvfrpe
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 501-798 5.3e-47 153.5 In-house 23-285 (307) alignment 
Range on Protein: 501-798
Range on HMM: 23-285/307.0
AELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNHHtgdihalSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNH
 |.| ..  |.| .  . .....  |. | ||.|||. ||. .|   | |           |.| ||.|||| .|||.. ||.. |. ||| . |.||||
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppet.......vyvftgdyvdrgllslecilllftykicypenivllrgnh

EDGDVNAYFGFKDECLGRLgPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIgkaslprvckgkgkgSPVLnsefTSVQQLRDIqrplPQPMTSSYA
|   ||  .|| .||.  . |  |  ||  ....|  ||..||.  ||||.|||.               || |    | ...||.     |.|.   . 
eiarvnkkygfyeecvtsi.pkcgeeiwalfqrcfnnlpisaliatkilcmhggl...............spal....tcldelrnh....pkpirnpfr

AILRDVLWADPtdnDYSLGIHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTINRELAVA
 |. |.|||||   | |.     . ||| .  || . ..   .   ...|.|||| .. ||  .. ..|||.|||  ||  | | |..| ..  | . 
givndmlwadp...dpsvfewkassrgsgf.tfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiq
subfamily_PPP6C_pd Subfamily PPP6C 500-656 9.8e-44 142.6 In-house 17-163 (290) alignment 
Range on Protein: 500-656
Range on HMM: 17-163/290.0
FAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTygspnhhTGDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGN
 ..|..| .     | ..|.| .| .|| | ||||||. ||. .| |       .|..   ||.|.||||||| .||| .|.||.||..||.|. |.|||
endlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt.......ggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgn

HEDGDVNAYFGFKDECLGRLGPTNghtIWERMNKVFGWLPLAALVDEKILCVHGGIG
||   .   .|| |||| . | .|    |  . |||  |..||..||..||||||. 
hesrqitqvygfydeclnkygnan...awkyctkvfdlltiaaiideqvlcvhGgls
subfamily_PPG1_pd Subfamily PPG1 511-657 2.6e-39 128.3 In-house 27-164 (300) alignment 
Range on Protein: 511-657
Range on HMM: 27-164/300.0
ETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTygspnhhTGDIHALSYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFG
   | ..| | .. .|| | ||.|||. |.|  |.         |..    |||.||.|||| .|.| ..||..|||||| |. |.|||||  ..   .|
kellvkesnvieirspvtvvgdvhgqfydvleifki.......ggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvyg

FKDECLGRLGPTngHTIWERMNKVFGWLPLAALVDEKILCVHGGIGK
|  ||| . |     ..|. . ..| .| |||..||.| |||||.  
fyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglsp
Metallophos Calcineurin-like phosphoesterase 526-757 1.4e-34 113.1 Pfam-A 2-199 (200) alignment 
Range on Protein: 526-757
Range on HMM: 2-199/200.0
PVKVFGDIHGQLADLLtfFdTYGSPNHHTGDIHALSYLFIGDFVDRGKFSLEVMTLL--LCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGR-----
.. |.||.||.|.||   . .    ... ..  .  .|| ||.||||. |.|.  ||  |.|||..| .|||.|||||.. .| ..||..|.|..     
rilvigDlHgglddle..d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrgla

-------------------------LGPTNGHTIWERMNKVFGWLPLAALVDEKILCVHGGIGKAS---LPRvckgkgkgspvlnseftsvqqlrdiqrp
                         |.| .|  ..|. ...| .|||.|||| |||..||....     ...                            
ngeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi............................

lpqpmtssyaailrdvlwadptdndyslgihantirgsEICNFGPDQVERFLQENNLQMIVRAHQCV
                                      . ..|||| .| .|.........|.|...
......................................gselfgpdalekllekygvdlvlrGHtHk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 676-805 2.5e-32 105.3 In-house 194-315 (317) alignment 
Range on Protein: 676-805
Range on HMM: 194-315/317.0
SEFTSVQQLRDIQRPLPQPmtssYAAILRDVLWADPTDNdysLGIHANTIRGSEIcNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSA
 |.....||  ..|||  |       .| |. ||||  .      .... ||.    ||.. |..||.. .|...||||| |  |||||| ..|.|.|||
eelldlkqldklkrpldip....dvGvladltwadpdae...vkgykesarGagk.vfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsa

TNYCGRYGNDGAMLTINRELAVAFSVIRPG
 .|||.  | .|.|.....| ....|.|| 
psycGqldniaavlsvdkklkisinvlrpe
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 561-657 3.1e-31 101.7 In-house 102-194 (317) alignment 
Range on Protein: 561-657
Range on HMM: 102-194/317.0
SYLFIGDFVDRGKFSLEVMTLLLCLKLRYPERVFLVRGNHEDGDVNAYFGFKDECLGRLGptngHTIWERMNKVFGWLPLAALVDEKILCVHGGIGK
 |||.||.|||| ||.||..||..|||.||..|||.|||||   ||  .||  |.  |      ....| ....|  |||.|.|..||||.|||| .
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys....aalyeafqlafnvlplcavvnkkilcmhGGise
subfamily_PPP6C_pd Subfamily PPP6C 674-795 3.8e-19 61.9 In-house 162-274 (290) alignment 
Range on Protein: 674-795
Range on HMM: 162-274/290.0
LNSEFTSVQQLRDIQRPLPQPMTSSYAailrDVLWADPTDNDYslgiHANTIRGSEICnFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVF
|... . ..|.| |.|    |   ...    |..|.|| | .      | . ||.    ||   .. |.. |||..|.|||| |  |.... ...|.||.
lspdvktldqirvieraqeiphkgafc....dlvwsdpedvet....wavsprgagyl.fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvw

SATNYCGRYGNDGAMLTINREL
|| ||| | ||  ..|... . 
sapnycyrcgnvasilaledae
subfamily_PPG1_pd Subfamily PPG1 701-801 2.5e-18 59.3 In-house 185-292 (300) alignment 
Range on Protein: 701-801
Range on HMM: 185-292/300.0
AILRDVLWADPTDNDY-------SLGIH-ANTIRGSEiCNFGPDQVERFLQENNLQMIVRAHQCVIAGYEFFAKQQLITVFSATNYCGRYGNDGAMLTIN
  | |.||.|| .|.          | |  .. ||.    .| | ||.||. |... |.|||| .  ||. .  ..| ||.|| ||| | ||  ..| ..
galadllwsdpeennnptldhpdregqhfvvsqrgag.ysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilely

RELAVAFSV
  .   | |
ekderyfnv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 496-552 3.3e-09 29.3 In-house 7-63 (317) alignment 
Range on Protein: 496-552
Range on HMM: 7-63/317.0
TLIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPNH
.|.| .||  |   |  .. ..   |.. |||.. ||||||  |||...| .| |  
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
EF-hand_7 EF-hand domain pair 60-123 1.5e-06 18.2 Pfam-A 5-66 (66) alignment 
Range on Protein: 60-123
Range on HMM: 5-66/66.0
IFRAMASKHAHHLTFDNFIVGLALLSSNTPhqDAWLPLRSEFIFKYYDSNRDDLLQLDEILKMF
.|... . .  .|. . .   |  |.|.    |  ..   ..|||..|.|.| .|...| |...
aFkllDkdgdgyldkeeLlrllkhlgspli..deevrevldyifkeiDkngdGvlsfeEflqai
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 497-551 2.7e-06 19.7 In-house 10-64 (339) alignment 
Range on Protein: 497-551
Range on HMM: 10-64/339.0
LIKFAELEALLACAETALKQDSTVLNVLAPVKVFGDIHGQLADLLTFFDTYGSPN
|.  |||  |   |   .  .  .|.. ||. |.||||||. |||...|  | | 
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl