Gene PPP5C in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP105_AA protein Get Run
MbreP105_AA_178-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 180-498 1.3e-178 585.9 In-house 1-320 (322) alignment 
Range on Protein: 180-498
Range on HMM: 1-320/322.0
TVPDSYTGPSFEMGNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVLNIFELNGRPSPENPYVFNG
|| |||.||..|...||||||.|..|.|.||...||||...|||.|..||.|||||....|.|..|||||||.||||||.||||||||.||.||||.|||
tvedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDGVTLDELRKID
|||||||||.|||||.|....||||.||.|||||||..||..|||.||||||||..|.||||||.|.|||.|||..|.|||||||||.||||||.|||||
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RFCQPPEEGLMCELLWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITL-TKDLE
|..|||||||..||||.|| ...||.||.||.|.|||||.||.||..|||.|.|||||.|||||||.||||.||.||||||||||||||||||| ..||.
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

PKFTQFDAVWHPDVKPMAYA
.||..|.||.||||||||||
lkfktfeavehpdvkpmaya
0045823 Metallo-dependent phosphatases 179-496 1.2e-104 343.5 In-house 10-333 (473) alignment 
Range on Protein: 179-496
Range on HMM: 10-333/473.0
LTVPDSYTGPSFEMgNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIpesnKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFN
 .|....|.| . . .... ......|...|........ ...| .|...|.| |.| ..      ...|.|| |||..| |...|..|.|.. . .||.
ipvlrlltlpllfi.llglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvfl

GDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKI
||.||||..| ||..  ||. |.||...|. |||||.  .| .||| .|. .||. .. . | |. .|||| .||..|||.|||||..    .||..|.|
GDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqirei

DRFCQPPEEGLMCELLWADPGPRPG--------RWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGK------CITIFSAPNYCDQM
.|....|..||...|||.|| .  |        . .| ||.| .||||....||..|.|.|..|.|.. .||||. .|||      .||.|||||||...
erpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrg

GNKGAFITLTKDLePKFTQFDAVWHPDVKPMA
||..|......|| ..|.|||.. || ..|..
gnlaAvlvidedl.isfiqfdpsphplilplf
PP2Ac_SM00156 214-485 4.1e-101 330.6 In-house 2-268 (271) alignment 
Range on Protein: 214-485
Range on HMM: 2-268/271.0
HKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGrPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNH
.|......|  . ..|.. ..|..|     ...||.||.|||..|.|...||.| ..||..|||.||.||||..|.||||...|. ||||. ... ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSrDGVTLDELRKIDRFCQPPEEGLMCELLWADP-GPRPGRWPSMRGTG
||...|..|||. |||.||...... |.|....|||. ....|||..|||| . .  .||..||..|. ..|||||...|||.||  . .|  ||.||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

LQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFD
 .||.|..|.||..|||||.||.||...||||. .|.|..||||||||||...||.|.... |.|.... |..
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
PPP_3 217-485 5e-96 313.8 In-house 6-270 (271) alignment 
Range on Protein: 217-485
Range on HMM: 6-270/271.0
YTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESE
   ... .. ..| | ..|....    ...|||||.|||..|. .... || ||||. |.|.||.||||..|.||.|..||. |.||..... ||||||.
elkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

RMNEMYGFTGEVK-AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCEL-LWADPGPRPGRWPSMRGTGLQ
..|..|||. ||.  |....| . ..||.. |||...|..|.|||||||...   .||...|..|... ||||....| |. ||  . |  .| ||.|| 
qinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsi.ksldqikklerkievpeegklldlllssdpekeeglenskrGagll

FGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFD
||||.|..|||.|.|||.||.||.||||||. ||||..|.|||||||....|.||...|...|...|.|..
FgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
0049330 Metallo-dependent phosphatases 193-492 1e-93 306.8 In-house 10-304 (309) alignment 
Range on Protein: 193-492
Range on HMM: 10-304/309.0
GNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFNGDFVDRGSFSCEVI
 ...........|...|. ...... ...||.|...|.. |.| ..      ...|.|| |||..| |...|..| |.. . .||.||.||||..|.||.
lelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevl

LTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCE
|. ||. .|||...|. |||||.  .| .||| .|...|| ... . |.....|||| .||..|||.|||||..   ..||..|...|....|..||.|.
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcd

LLWADPG-PRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVWHPD
|||.||   |.| .|. || |  ||......||..|.|.|.||.|.. ..||.. .|||.||.|||||||...||.||......||.. |..|..| .. 
llwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll

V
.
l
PPP_1 227-472 2.1e-90 295.6 In-house 11-263 (264) alignment 
Range on Protein: 227-472
Range on HMM: 11-263/264.0
DLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTG
. |..|.. ... .  |...|||||.||||.|. ...  .| ||||. |.|.||.||||..|.|..|..||. . ||...|. ||||||......|||. 
kklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkk

EVK-AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCELL-------WA-DPGPRPGRWPSMRGTGLQFGP
||.  ||.... ...|.|.. |||. .|..|||.||||| .    .||. ||..|. . |||| .|.||       .  |.  . .   |.||.| .||.
EvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspel.dlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgk

DITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
|.|..||..|||||.||.||.||||||.....|..|||||.||.....|.||...
dvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0053225 Metallo-dependent phosphatases 194-488 9.7e-87 284.0 In-house 3-292 (293) alignment 
Range on Protein: 194-488
Range on HMM: 3-292/293.0
NITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFNGDFVDRGSFSCEVIL
.... ... ..|..... ...... ...||.|...|.| |.| ...     ...|.|| ||...| |...|. | |.. . .||.||.||||..| ||..
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

TFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY-TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCE
 .||. .|||..... |||||.  .| .||| .|...||  ... | ......|||| ..|..|||.||||| | | ..||..|.|.|....|.|||...
lllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllld

LLWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVW
||| ||  . | .||.|| |  ||......||..|.|.|.||.|..  .||.. .|||..|.||||||....||.||...| ..| ..|..|..|.
llwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP1C_pd Subfamily PPP1C 209-482 1.8e-81 266.4 In-house 6-274 (282) alignment 
Range on Protein: 209-482
Range on HMM: 6-274/282.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFM
|. .....   ..| .| ..| . | | ... |    ....|| |||..|.|..|| .| | ||. |.| ||.||||..| |.|. .|||.| ||...|.
kevklkeaeieallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfl

SRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWP-S
 ||||||  .|..|||  |.| .|....   ||.|.| |||  ....|||.||||| | .   |...||| | .. ||.||.|.|||.||  .   |  .
lrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsen

MRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFT
 ||  ..||.|. ..||..|.|.|..|.|.. |.|||   . . .|.|||||||....|.|| ......|  .|.
drGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_PPP2C_pd Subfamily PPP2C 200-486 2.7e-78 256.1 In-house 4-285 (290) alignment 
Range on Protein: 200-486
Range on HMM: 4-285/290.0
VEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYR
.....|.... ......   ..  .| ..|.|   . .|..|    .||||| ||||.|.|..| . |. ||.  |.| ||.|||| .| | .  . | .
ldklieklkeckqleesevkelcekakeilskesnvqevkcp....vtvcgdvhgqfhdllelfkiggk.spdtnylflgdyvdrgyysvetvtllvalk

ILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADP
. |..   . |||||| .. ..||| .|.  ||.. .|  .||.... |||  .....|...|||| |    |||..|..||. . |.|| .|.|||.||
vrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdp

GPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
  | |   | ||.| .|| ||...| ..|.|.|..|.|..  |||...|| . .||||||||| . ||..| . | ..|. .| |||.
ddrggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_PPP3C_pd Subfamily PPP3C 200-491 3.5e-76 249.8 In-house 28-326 (452) alignment 
Range on Protein: 200-491
Range on HMM: 28-326/452.0
VEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSpENPYVFNGDFVDRGSFSCEVILTFLAYR
.| . | | |.  .... ...|. .| .||.| ..| .|  |    .||.|| ||||||.|..||..| |. .  |.| ||.||||.||.|..| ..| .
levlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalk

ILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
| ||...|. |||||.  . | . |  |.| ||. .| | ..| ..||||  ..... | ||||| | .  .||...|.||| .||. |..|.|||.|| 
iaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPl

PRPGRWP--------SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHD------GKCITIFSAPNYCDQMGNKGAFITLTKDlEPKFTQFD
 . |           |.||    ..   . .||..|.|  .||.|| ...||.. ..         ||.||||||.|   ||.| . . .. . .  ||.
edygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfn

AVWHPD
.. || 
ssphpy
subfamily_PPP4C_pd Subfamily PPP4C 201-487 3.2e-75 246.0 In-house 4-285 (288) alignment 
Range on Protein: 201-487
Range on HMM: 4-285/288.0
EEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRI
....|. |. | |...   ..   | ..| .   .. |  |     ||||| ||||||.|..|...|   ||. |.| ||||||| .| | .| .||...
drqieklrrcelikeeevkalcakareilveesnvqrvdsp....vtvcgdihgqfydllelfkvggd.vpetnylflgdfvdrgfysvetfllllalkv

LYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
 ||.   . |||||| .. ..|||  |.  || | .|  . |||.. |.|. .|..||..||||| | .  ||||.| |||  . |.|| .|.|||.|| 
rypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpe

PRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAV
   |   | ||.|  || |...|| |.|...|..|.|..  ||| .  . | .|..|||||| . ||. | . | ..|. .|. |.|.
daegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 194-482 1.6e-74 243.6 In-house 5-289 (298) alignment 
Range on Protein: 194-482
Range on HMM: 5-289/298.0
NITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSPENpYVFNGDFVDRGSFSCEVIL
..  |...  ... .  ..|...   ... .| ....| .|| .|  |    ..|||| |||. |.| .|. .| |  .| |.| ||.||||... |||.
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnleviv

TFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY-TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCE
 .|||.. ||| ||. ||||| | .|..|||  |.| .|   ..   | .|.|.|||  .| ..|| .|||| |.  ..||.||.. |  ...|| |  .
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWADPGPR-PGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFT
||||||     |  .. || . .|| |  |..||. .. |..|.| .  .|||   . | .||||||.||.|. |  |.... ..|.  |.
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfe
PPP_4 247-439 9.3e-70 227.7 In-house 2-197 (197) alignment 
Range on Protein: 247-439
Range on HMM: 2-197/197.0
TVCGDTHGQFYDV-LNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYN
||.||.|||..|. |..... |.||.|. |||.||.||||..|.||.|..||. . ||. ... ||||||. .|..|||. ||. |....... ...|..
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

SLPLGHVIEDKILVVHGGLFSRDGvTLDELRKIDRFCQPP-EEGLMCEL-LWADPG-PRPGrW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
 ||| ..|..|.|||||||..    .||....|.|... | ||.....| ||.||     | . .| || || ||||.|..|||.|||||.|||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshelk
subfamily_PPP6C_pd Subfamily PPP6C 210-488 3.3e-69 226.2 In-house 12-285 (290) alignment 
Range on Protein: 210-488
Range on HMM: 12-285/290.0
QETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMS
 . . ..   ..  .  ||| .  ..  |. |    .||||| ||||||....|   |.  |.. ||| ||||||| .| | .  .|. .. ||.   . 
ckylpendlkklcdlvldllleesnvqpvssp....vtvcgdihgqfydleelfrtggq.vpdtsyvflgdfvdrgyysletftrlltlkakypdritll

RGNHESERMNEMYGFTGEVKAKYT-SQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWPSM
|||||| .. ..|||  | . ||  ...   .|.|.. |... .|....| ||||| | |  |||..| |.|  . |..| .|.|.|.||        | 
rgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsp

RGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVW
||.|  ||  .||.|.. |||||..|.|.. |||..   | | .|..|||||| . ||  . ..| .. | ..  |.|| 
rgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavp
PPP_2 247-439 9.9e-69 224.0 In-house 2-198 (198) alignment 
Range on Protein: 247-439
Range on HMM: 2-198/198.0
TVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK-AKYTSQVMDLFTEVYN
|||||.|||..|. .|.  || ||||. |.|.||.||||..|.||.|..||. . ||..... ||||||...|..|||. ||.  |....|.. ..||..
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

SLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPPEEGLMCEL-----LWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
 |||...|..|.|||||||...   .||. .|..|... ||||....|     |. ..  . .  .| ||.|| ||||.|...||.|.|||.||.||.|
lLplaalidekvlvvHGGlsee.iklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 210-484 1.4e-67 221.1 In-house 5-280 (284) alignment 
Range on Protein: 210-484
Range on HMM: 5-280/284.0
QETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP-----SPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPN
|. ...|  |.. . | .|. | .   ....|    ....|| |||| |.| ...||| |     . |. |.| ||.|||| || |||. ..||..|.|.
qkllkekelielcyrarelfwkeklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

SFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGR
  |. ||||||  .|  |||  | | .|. .. . |   .|..||  |...||. .|||. | | . |..| |..| .. |. |....| ||||  .   
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaeveg

W-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
.  | ||.|  ||..  |.||.. .|.|..|.|..  .|||   | | .|||||| || |. | .| ... ..|.  || .
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
PPP_5_Dcr2 247-439 2.4e-67 219.8 In-house 2-199 (199) alignment 
Range on Protein: 247-439
Range on HMM: 2-199/199.0
TVCGDTHGQFYDVLNIFELNG-RPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAK-YTSQVMDLFTEVY
|||||.|||..|.| |.. .| .||.|. |||.||.||||..|.||.|. ||. ..||. ... |||||.| .||.|||| ||. | . ..... ...|.
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NSLPLGHVIEDKILVVHGGLFSRDGvTLDELRKIDRFCQPP-EEGLMCEL-LWADPG-PRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
. ||| ..|..|.|||||||..    ....|.||.|... | |.| ...| ||.||     | . .| || || ||||.|..|||.|||||.|||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 244-481 1.3e-66 217.6 In-house 33-269 (280) alignment 
Range on Protein: 244-481
Range on HMM: 33-269/280.0
NKLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEV
  ..|||| |||. |.| .|.  . | |.. |.| ||.||||..  ||||  |||.. |||.|.. |||||  ..|. |||  ||| .|. .. . | |.
apvavcgdlhgqytdllrlfarvsfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqel

YNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEG
..||||  ..  .||..|||| |.. |.||.|... |  ....| |  .||||||  .   |  . ||.  .|| .. |.. |. .. |..| |.. ..|
ldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdg

YEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
||   | | .|.||||.|.... |. | . . . |.  |
yeffadkklvtvfsapkylgefdnsaavlivderlivsf
subfamily_PPG1_pd Subfamily PPG1 202-486 5.5e-64 209.3 In-house 3-295 (300) alignment 
Range on Protein: 202-486
Range on HMM: 3-295/300.0
EMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGrPSPENPYVFNGDFVDRGSFSCEVILTFLAYRIL
| .|...| | . .    ..     .|| |   . ..| |    .|| || ||||||||.||.. | . |.  |.| ||.|||| .| | |  ... .. 
ecleklqkaellpevtvkeltdklkellvkesnvieirsp....vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklr

YPNSFFMSRGNHESERMNEMYGFTGEVKAKY--TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
||    . |||||| .. ..||| .|.  ||   |.| . .||... | |  .|...| .||||| | .  ..|... .||| . |.|| ...|||.|| 
ypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpe

-------PRPGRW-----PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
        .| |       | ||.|  .| |....||. |... .||.|..  |||..  |.|  |..|||||| . ||| . . | . .|  |  ...
ennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyee
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 218-484 9.2e-64 208.4 In-house 13-274 (281) alignment 
Range on Protein: 218-484
Range on HMM: 13-274/281.0
TIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESER
 .... ..  .. .  .|...  |     .| || |.|| |. ..||| ||. ||. .|| ||.||||  | ||.. .....| |..  .. |||||  .
ienvireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFG
.| .|||  | . ||  ..  || . .| ||.   |. ..|..|||| | . ..|||||.. . ..... ||. .|||||| ..   |  |.||..  ||
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

PDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
 .. ..   . .. |.||.| .  .||||    | ||.||.||||..  | .| ... ..|. .. ..
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_PPP7C_pd Subfamily PPP7C 181-380 8.8e-63 205.3 In-house 2-201 (383) alignment 
Range on Protein: 181-380
Range on HMM: 2-201/383.0
VPDSYTGPSFEMgNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVLNIFELNGRPSPENPYVFNGD
|.|||||| ...  .||. ||...|.|......| || ..||  | . |..||... |    |...||||| ||.. |.| |.  || ||.|||||||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY---TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFsrDGVTLDELRK
|||||. | |..| .||. ..||..... |||||   .|  |||. ||. ||   ..... |. .|.  |||. .|..|||.||||.   |   |. | |
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis..dktdlelldk

IDR
|.|
ier
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 207-484 3.6e-62 202.9 In-house 4-279 (287) alignment 
Range on Protein: 207-484
Range on HMM: 4-279/287.0
FRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSF
.   ...  |  ...|  . ..|. ||.| .|. |    .|..||.|||. |.|.||.  |.. |.  |.| ||.||||. | ||.| .....|.||.. 
ygvldafsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkv

FMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPP--EEGLMCELLWADPGPRPG-
 . ||||| ...|..|||  |.| |. ...   | .|.. |||   .. .|| .|||. |..  .||.|. . .  .|   .|||. .||||||      
hllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdakt

-RWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
 .   .|.    ||     ..|.. ...|..|.||..||||.   | ...|.|||| |. .  | || ....| || .|...
felnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 209-481 1.4e-61 201.4 In-house 20-288 (299) alignment 
Range on Protein: 209-481
Range on HMM: 20-288/299.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFM
  ......  ...  .| . . . .|| .|  |    . |||| |||. |.| ||. .| | |.  ..| ||.||||    |.|  .|...| ||. |||
ltksvkeqelqtlcavaksvfasqaslleveap....iivcgdihgqysdllrifdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperffm

SRGNHESERMNEMYGFTGEVKAKYTSQ-VMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-P
 |||||   .| .|||  |.. .|.|  .  .| . .. .||  .|  .||..|||| |    ||| ||.. |  .||.  |  .||||||      | .
lrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwla

SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
 .||    ||.|. .. ... .. |. |.|.. ..|||   . | .|||||| || |. |  | . . ..|   |
nvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctf
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 274-484 1.8e-61 201.1 In-house 102-312 (317) alignment 
Range on Protein: 274-484
Range on HMM: 102-312/317.0
PYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLD
 |.| ||.|||| || ||.. ..|...|||.  |. ||||||  .|  |||  ||| .| ... . |  ..| |||  |...||| .|||. | . . |.
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldlk

ELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
.| |..| .. |. |....| |||| ..   . .| ||.|  ||..  |.||.. .|.|..|.|.. |.|||   | | .||||||.|| |. | .| ..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

LTKDLEPKFTQF
. |.|.  .. .
vdkklkisinvl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 211-481 6.8e-60 195.8 In-house 21-289 (297) alignment 
Range on Protein: 211-481
Range on HMM: 21-289/297.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSR
. | ..  ...| .| |....  |. .|  |    . |||| |||| |.| .|   | | |   |.| ||.|||| || | |. .|||.. .|  .|. |
kviteervlklldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllr

GNHESERMNEMYGFTGEVKAKYTSQVM-DLFTEVYNSLPLGHVIEDKILVVHGGLFS--RDGVTLDELRKIDRFCQpPEEGLMCELLWADPGP-RPGRWP
|||| | .|..|||  |.. .| |  |   | .|.| |||  .| .|||..||||     . .||| ||||.|  .  .|.|...||||||     |   
gnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfme

SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
  ||.|  || |   .   . .| |. |.|.. ..|||.    | .|||||| || |. |  ||..  . |.  |
nqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 202-483 3.3e-58 190.0 In-house 5-285 (290) alignment 
Range on Protein: 202-483
Range on HMM: 5-285/290.0
EMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRIL
| ....   ...  |  ..||  . ..|. ||.| .|  |    ... || |||. ..|. |.  |.| |.  ..| ||.||||. | || | .. |.|.
ehllkygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgyp.pkvkflflgdyvdrgakslevslllfcykir

YPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDR--FCQPPEEGLMCELLWADPG
|...  . |||||  ..| .|||  |.  | .|..   . .|.. |.|   .. ||| .|||. |..  . . |. . .       .|||. .|||||| 
yskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwadpt

P---RPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQ
       .   .|.    || .   ..|..  |.|..|.||.||||..   | |..|.|||| |. .  | || .|... || ... 
rdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv
subfamily_PPZ_pd Subfamily PPZ 211-486 1.4e-55 181.9 In-house 23-293 (300) alignment 
Range on Protein: 211-486
Range on HMM: 23-293/300.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVripeSNKLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSR
  ....  .||   | .|.   |.| ..    |  . . || |||. |.| .|   | | | . |.| ||.||||  | | || .|.|.| ||. ||. |
vclknseilqicikarelflaqpallel....spsvkivgdvhgqyadllrlftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllr

GNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWPS-MR
||||   .  .|||  |.| .   ..   | . .|.|||  ..  ||..||||| |    ..||.|.. |  . |. ||. .|||.||   .  |    |
gnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhggl.spvlnsmdeirhvvrptdvpdfglindllwsdptdssnewedner

GTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
|    .     ..||..  . |. |.| . |.|||.  |   .|.||||||| .. | || ..... |   |  .| 
gvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 220-481 1.7e-55 181.4 In-house 10-268 (284) alignment 
Range on Protein: 220-481
Range on HMM: 10-268/284.0
QILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSPENpYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMN
 .|. |.... | | | .|  |    . .||| |||| |.| .|. || |   | |.| ||.||||    | || ..||....|| ||| |||||   .|
tllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

EMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPE-EGLMCELLWADPGPR-PGRWPSMRGTGLQFG
..|||  |.. .|    |.  |  |.  .||  .. ..||..|||. |.    . .|| | |  . || . |  ..||.||     |  |  ||    ||
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

PDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
 |  ...|.. .. |..|.|.. ..|||.  . . .|||||| || |. |  | . . |.|   |
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsf
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 246-475 2e-52 171.3 In-house 49-280 (307) alignment 
Range on Protein: 246-475
Range on HMM: 49-280/307.0
LTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK---AKYTSQVMDLFTE
  | || |||| |..|.| | ||| ||  ||| ||.|||| .| |.|| ...|.| ||..  . |||||  |.|. |||  |.     |   ..  ||  
cvvvgdlhgqfndlinmfillgrp.petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqr

VYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWP-SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEE
..| ||.  .|  |||..|||| |     |||||.  .  . |  |.. ..||||| |    |  | ||.|. || ..  .      ..|.||.|.|  .
cfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfd

GYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTK
|| |    | ||||||| ||.   | |. . . .
gywvlsgrklitifsapmycnfyknagcvlkvde
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 245-484 7e-52 169.6 In-house 34-272 (280) alignment 
Range on Protein: 245-484
Range on HMM: 34-272/280.0
KLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVY
 . | || | |. |.  .|.| ||  ||.  .| ||.||||    ||.. ... .| | .  .. |||||.  .|..|||  |.. ||   .   |  ..
pikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscf

NSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGY
| .|.  .|  ..|..|||| | . . || .|.| | |.| . ||. .|||.||  .   |  |.||    ||  . .|  .  .. |.||.|.. ..||
nrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgy

EVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
|.    . ||.|| |||| |. |  | . |  .|.  | |.
emmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 274-478 4.9e-49 160.2 In-house 121-325 (339) alignment 
Range on Protein: 274-478
Range on HMM: 121-325/339.0
PYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLD
 |.| ||.|||| || ||.. . | .. ||.  .. ||||||  .|  |||  ||. .| .|. . | ...| .|.  ||.. |...|||. |    ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

ELRKIDRFCQPPEEGLMCELLWADPGPR-PGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
..  . |  . |. |.. .| |||| |   |  || ||. . |||   . ||.. .|...|| |.. |.|||.    . .||||||||| |  |  | ..
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LTKDLE
. | |.
idkklk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 209-474 6.2e-41 133.5 In-house 3-288 (302) alignment 
Range on Protein: 209-474
Range on HMM: 3-288/302.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP----------SPENPYVFNGDFVDRGSFSCEVILTFLAY
.... .|.  .... .  .||.|  .|...  |    .|. || |||| |.. |.  .               .. .|| ||.||||| | | |   .|.
rkkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfal

RILYPNSFFMSRGNHESERMNEMYGFTGEVKAK----YTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPP-EEGLMCEL
..|||. . . |||||.. .|  ||| .|.. .     . .. . | ||.  .||  .. .||| ||||.  .   .|....||.|  .   |. |  .|
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdl

LWADPGPR-----PGRWP-----SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLT
|.|||        . . |      .||  . |     ... .. ||||..|.| |  ||.    | | .||||||.| ... |||| . . 
lfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 209-474 7.3e-41 133.3 In-house 2-287 (302) alignment 
Range on Protein: 209-474
Range on HMM: 2-287/302.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP----------SPENPYVFNGDFVDRGSFSCEVILTFLAY
.... .|.  .... .  .||.|  .|...  |    .|. || |||| |.. |.  .               .. .|| ||.||||| | | |   .|.
rkkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfal

RILYPNSFFMSRGNHESERMNEMYGFTGEVKAK----YTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPP-EEGLMCEL
..|||. . . |||||.. .|  ||| .|.. .     . .. . | ||.  .||  .. .||| ||||.  .   .|....||.|  .   |. |  .|
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdl

LWADPGPR-----PGRWP-----SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLT
|.|||        . . |      .||  . |     ... .. ||||..|.| |  ||.    | | .||||||.| ... |||| . . 
lfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 246-484 1.9e-39 128.9 In-house 9-253 (263) alignment 
Range on Protein: 246-484
Range on HMM: 9-253/263.0
LTVCGDTHGQFYDVLNIFELNGRPSpENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-----QVMDLF
. .|||||||. |.| ||.  |  . .  |.| ||.|||| .| |||. ... ..  |  ... ||||| . .|. |||  |.| ..        | . |
inicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQP-PEEGLMCELLWADPGPRP-GRWP-SMRGTGLQFGPDITKQFLEHNNLKLLIRSHE
 .|.. .||  ..  .||..|||. |    .||..| |    .      | |.||||||     |  |  .|     ||     .. .. .. |..|.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

MKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
. | || .  | . ||.|||  |  .. |  | . . | ||  | |.
vveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvql
Metallophos Calcineurin-like phosphoesterase 245-439 3.9e-38 124.7 Pfam-A 2-199 (200) alignment 
Range on Protein: 245-439
Range on HMM: 2-199/200.0
KLTVCGDTHGQFYDV---LNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTF--LAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK----------
. .|.||.||...|    |.|.. .. ... ....|.||.||||  | |..  .  |.. .|.|. .|. ||||||  .|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDGVTLDElrkidrfcqppeeglmcellwadpgprpgrw
                         ...  . . . |... ||| . .. |||..||.|.|..| ..|.                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

psmrgTGLQFGPDITKQFLEHNNLKLLIRSHEMK
      .  |||| .  .|| ....|..|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPPLV_pd Subfamily PPPLV 247-475 5e-36 117.5 In-house 27-277 (290) alignment 
Range on Protein: 247-475
Range on HMM: 27-277/290.0
TVCGDTHGQFYDVLNIFELNGRP---SPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQ---VMDLF
 | || ||.. |.  . .   |         ..| ||.|||| || |.|  .|| ..|||  ... ||||| | . | . . || . |.  .   | . |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

TEVYNSLPLGHVIEDKILVVHGGLF--SRDGVTLDELRKIDRFCQPPEEG--LMCELLWADPGP------------RPGR-WPSMRGTGLQFGPDITKQF
..|.. |||  ||..|.. ||.|.   .  .  .  ...|    . . .|  |  ..||.||                |    . ||||  |. |  ..|
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

LEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQmGNKGAFITLTK
|..|||. ..|.||.||.|... ..|. .|.||. .|| .  |. | | . |
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk
subfamily_PPP7C_pd Subfamily PPP7C 390-486 6.3e-34 110.3 In-house 237-334 (383) alignment 
Range on Protein: 390-486
Range on HMM: 237-334/383.0
MCELLWADPGPRPGRWPS-MRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
. ..||.||  . | .|  .||.|  ||||.||..|.. |||||||||| | ||||..|| |..||||| || ..  |.||.. |.|||.|.. |. |
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqa
PPP5 PPP5 TPR repeat region 142-238 2.1e-28 88.6 Pfam-A 1-95 (95) alignment 
Range on Protein: 142-238
Range on HMM: 1-95/95.0
KLKGVEKMIHQLAFAKAIAVEHNTISAVEKLrqNLENLTVPDSYTGPSFEMGNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDV
|||  ||.....|| |||.|... .|..|..  ..|.... |.|.|| .| ...|.|||.|..|.|.||. .|||. .||||   .||.||||| ..
KlkeCeklvkkiaFekAIevdeekrsvaesi..diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
TPR_11 TPR repeat 43-99 1.4e-16 49.5 Pfam-A 10-68 (69) alignment 
Range on Protein: 43-99
Range on HMM: 10-68/69.0
GNKAFKNKSFHAAIDAYTEAIDLDP-QPAYYCNRAFAYLKTE-AWGAAVNDANEALKLD
||..||.. .. ||.||..|..|||  . .|.|.| ||||    . .|. |...||.||
GnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleld
TPR_11 TPR repeat 87-134 9.7e-09 24.4 Pfam-A 21-69 (69) alignment 
Range on Protein: 87-134
Range on HMM: 21-69/69.0
AAVNDANEALKLDDRFIKAYYRRATANMNLG-HLKASRRDFEAVLKVKP
 |.   ..||.||.   ..||..| | ..|| . .. ..|.| .|.  |
eAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_9 Tetratricopeptide repeat 78-141 4.5e-07 19.1 Pfam-A 4-67 (73) alignment 
Range on Protein: 78-141
Range on HMM: 4-67/73.0
AYLKTEAWGAAVNDANEALKLDDRFIKAYYRRATANMNLGHLKASRRDFEAVLKVKPSDKDAQQ
.||  | . .| . ..  | |.      .. |. . . ||.| | ..|.|| |.. |.. ||..
iylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcpdapdael
TPR_16 Tetratricopeptide repeat 75-136 1.1e-06 18.8 Pfam-A 3-64 (65) alignment 
Range on Protein: 75-136
Range on HMM: 3-64/65.0
RAFAYLKTEAWGAAVNDANEALKLDDRFIKAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
.| |.|.   . .|.. ...||.|. .   |....| | . .|.|.|... ..| |.  |.|
lArallraGdydeAlaaleaalalaPeaaeallllaeallrqgrldaAaallraalalaPdd
TPR_1 Tetratricopeptide repeat 43-68 1.2e-06 17.6 Pfam-A 8-33 (34) alignment 
Range on Protein: 43-68
Range on HMM: 8-33/34.0
GNKAFKNKSFHAAIDAYTEAIDLDPQ
||  .|.. .  |...| .|. |.|.
GnaylklgkydeAleyyekALelnPn
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 211-270 1.4e-06 20.7 In-house 7-62 (317) alignment 
Range on Protein: 211-270
Range on HMM: 7-62/317.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPS
. ...|  |.. . | .|. | |   ....|    .|..|| |||| |.| ...||| | 
dlfkekelielcyrarelfwkeplkleleap....vtivGdihGqfedllalldlnGwpl
subfamily_YNL217W_pd Subfamily YNL217W 244-370 2.7e-06 20.1 In-house 10-142 (235) alignment 
Range on Protein: 244-370
Range on HMM: 10-142/235.0
NKLTVCGDTHGQFYDVLNIFE-LNGRPSPENPYVFNGDFVDRGSFSCEVIlTFLayrilYPNSFFMSRGNHESERMN------EMYGFTGE---VKAKYT
 .| | || || . .......  .|   ..   |. ||....|  | ||.  ..       .     .||||   .       .  |..      | .. 
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevv.syv.....rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfl

-SQVMDLFTEVYNSLPLG-HVIEDKILVVHGGLFSRDGV
 |.. .  .| . .|.   ..  |..||||.|| . . .
esklskadmeyarelgfsldipsdellvvhaGlvpgkfl
TPR_2 Tetratricopeptide repeat 104-136 3.4e-06 16.5 Pfam-A 2-34 (34) alignment 
Range on Protein: 104-136
Range on HMM: 2-34/34.0
KAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
.|.|... | ..||...  ...|| .|.  | .
ealynlGlayyklgdyeeAleafekAleldPnn
TPR_1 Tetratricopeptide repeat 104-136 6.1e-06 15.4 Pfam-A 2-34 (34) alignment 
Range on Protein: 104-136
Range on HMM: 2-34/34.0
KAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
||.|... | ..|| ..    ..| .|.. |..
kalynlGnaylklgkydeAleyyekALelnPnn