Gene PPP5C in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP105_AA protein Get Run
MbreP105_AA_178-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 180-498 1.3e-178 585.9 In-house 1-320 (322) alignment
Range on Protein: 180-498
Range on HMM: 1-320/322.0
TVPDSYTGPSFEMGNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVLNIFELNGRPSPENPYVFNG
|| |||.||..|...||||||.|..|.|.||...||||...|||.|..||.|||||....|.|..|||||||.||||||.||||||||.||.||||.|||
tvedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDGVTLDELRKID
|||||||||.|||||.|....||||.||.|||||||..||..|||.||||||||..|.||||||.|.|||.|||..|.|||||||||.||||||.|||||
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RFCQPPEEGLMCELLWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITL-TKDLE
|..|||||||..||||.|| ...||.||.||.|.|||||.||.||..|||.|.|||||.|||||||.||||.||.||||||||||||||||||| ..||.
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

PKFTQFDAVWHPDVKPMAYA
.||..|.||.||||||||||
lkfktfeavehpdvkpmaya

0045823 Metallo-dependent phosphatases 179-496 1.2e-104 343.5 In-house 10-333 (473) alignment
Range on Protein: 179-496
Range on HMM: 10-333/473.0
LTVPDSYTGPSFEMgNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIpesnKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFN
 .|....|.| . . .... ......|...|........ ...| .|...|.| |.| ..      ...|.|| |||..| |...|..|.|.. . .||.
ipvlrlltlpllfi.llglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvfl

GDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKI
||.||||..| ||..  ||. |.||...|. |||||.  .| .||| .|. .||. .. . | |. .|||| .||..|||.|||||..    .||..|.|
GDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqirei

DRFCQPPEEGLMCELLWADPGPRPG--------RWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGK------CITIFSAPNYCDQM
.|....|..||...|||.|| .  |        . .| ||.| .||||....||..|.|.|..|.|.. .||||. .|||      .||.|||||||...
erpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrg

GNKGAFITLTKDLePKFTQFDAVWHPDVKPMA
||..|......|| ..|.|||.. || ..|..
gnlaAvlvidedl.isfiqfdpsphplilplf

PP2Ac_SM00156 214-485 4.1e-101 330.6 In-house 2-268 (271) alignment
Range on Protein: 214-485
Range on HMM: 2-268/271.0
HKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGrPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNH
.|......|  . ..|.. ..|..|     ...||.||.|||..|.|...||.| ..||..|||.||.||||..|.||||...|. ||||. ... ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSrDGVTLDELRKIDRFCQPPEEGLMCELLWADP-GPRPGRWPSMRGTG
||...|..|||. |||.||...... |.|....|||. ....|||..|||| . .  .||..||..|. ..|||||...|||.||  . .|  ||.||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

LQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFD
 .||.|..|.||..|||||.||.||...||||. .|.|..||||||||||...||.|.... |.|.... |..
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk

PPP_3 217-485 5e-96 313.8 In-house 6-270 (271) alignment
Range on Protein: 217-485
Range on HMM: 6-270/271.0
YTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESE
   ... .. ..| | ..|....    ...|||||.|||..|. .... || ||||. |.|.||.||||..|.||.|..||. |.||..... ||||||.
elkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

RMNEMYGFTGEVK-AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCEL-LWADPGPRPGRWPSMRGTGLQ
..|..|||. ||.  |....| . ..||.. |||...|..|.|||||||...   .||...|..|... ||||....| |. ||  . |  .| ||.|| 
qinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsi.ksldqikklerkievpeegklldlllssdpekeeglenskrGagll

FGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFD
||||.|..|||.|.|||.||.||.||||||. ||||..|.|||||||....|.||...|...|...|.|..
FgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

0049330 Metallo-dependent phosphatases 193-492 1e-93 306.8 In-house 10-304 (309) alignment
Range on Protein: 193-492
Range on HMM: 10-304/309.0
GNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFNGDFVDRGSFSCEVI
 ...........|...|. ...... ...||.|...|.. |.| ..      ...|.|| |||..| |...|..| |.. . .||.||.||||..|.||.
lelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevl

LTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCE
|. ||. .|||...|. |||||.  .| .||| .|...|| ... . |.....|||| .||..|||.|||||..   ..||..|...|....|..||.|.
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcd

LLWADPG-PRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVWHPD
|||.||   |.| .|. || |  ||......||..|.|.|.||.|.. ..||.. .|||.||.|||||||...||.||......||.. |..|..| .. 
llwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll

V
.
l

PPP_1 227-472 2.1e-90 295.6 In-house 11-263 (264) alignment
Range on Protein: 227-472
Range on HMM: 11-263/264.0
DLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTG
. |..|.. ... .  |...|||||.||||.|. ...  .| ||||. |.|.||.||||..|.|..|..||. . ||...|. ||||||......|||. 
kklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkk

EVK-AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDgVTLDELRKIDRFCQPPEEGLMCELL-------WA-DPGPRPGRWPSMRGTGLQFGP
||.  ||.... ...|.|.. |||. .|..|||.||||| .    .||. ||..|. . |||| .|.||       .  |.  . .   |.||.| .||.
EvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspel.dlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgk

DITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
|.|..||..|||||.||.||.||||||.....|..|||||.||.....|.||...
dvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk

0053225 Metallo-dependent phosphatases 194-488 9.7e-87 284.0 In-house 3-292 (293) alignment
Range on Protein: 194-488
Range on HMM: 3-292/293.0
NITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRipesNKLTVCGDTHGQFYDVLNIFELNGRPSPeNPYVFNGDFVDRGSFSCEVIL
.... ... ..|..... ...... ...||.|...|.| |.| ...     ...|.|| ||...| |...|. | |.. . .||.||.||||..| ||..
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

TFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY-TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCE
 .||. .|||..... |||||.  .| .||| .|...||  ... | ......|||| ..|..|||.||||| | | ..||..|.|.|....|.|||...
lllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllld

LLWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVW
||| ||  . | .||.|| |  ||......||..|.|.|.||.|..  .||.. .|||..|.||||||....||.||...| ..| ..|..|..|.
llwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl

subfamily_PPP1C_pd Subfamily PPP1C 209-482 1.8e-81 266.4 In-house 6-274 (282) alignment
Range on Protein: 209-482
Range on HMM: 6-274/282.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFM
|. .....   ..| .| ..| . | | ... |    ....|| |||..|.|..|| .| | ||. |.| ||.||||..| |.|. .|||.| ||...|.
kevklkeaeieallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfl

SRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWP-S
 ||||||  .|..|||  |.| .|....   ||.|.| |||  ....|||.||||| | .   |...||| | .. ||.||.|.|||.||  .   |  .
lrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsen

MRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFT
 ||  ..||.|. ..||..|.|.|..|.|.. |.|||   . . .|.|||||||....|.|| ......|  .|.
drGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq

subfamily_PPP2C_pd Subfamily PPP2C 200-486 2.7e-78 256.1 In-house 4-285 (290) alignment
Range on Protein: 200-486
Range on HMM: 4-285/290.0
VEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYR
.....|.... ......   ..  .| ..|.|   . .|..|    .||||| ||||.|.|..| . |. ||.  |.| ||.|||| .| | .  . | .
ldklieklkeckqleesevkelcekakeilskesnvqevkcp....vtvcgdvhgqfhdllelfkiggk.spdtnylflgdyvdrgyysvetvtllvalk

ILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADP
. |..   . |||||| .. ..||| .|.  ||.. .|  .||.... |||  .....|...|||| |    |||..|..||. . |.|| .|.|||.||
vrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdp

GPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
  | |   | ||.| .|| ||...| ..|.|.|..|.|..  |||...|| . .||||||||| . ||..| . | ..|. .| |||.
ddrggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp

subfamily_PPP3C_pd Subfamily PPP3C 200-491 3.5e-76 249.8 In-house 28-326 (452) alignment
Range on Protein: 200-491
Range on HMM: 28-326/452.0
VEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSpENPYVFNGDFVDRGSFSCEVILTFLAYR
.| . | | |.  .... ...|. .| .||.| ..| .|  |    .||.|| ||||||.|..||..| |. .  |.| ||.||||.||.|..| ..| .
levlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalk

ILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
| ||...|. |||||.  . | . |  |.| ||. .| | ..| ..||||  ..... | ||||| | .  .||...|.||| .||. |..|.|||.|| 
iaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPl

PRPGRWP--------SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHD------GKCITIFSAPNYCDQMGNKGAFITLTKDlEPKFTQFD
 . |           |.||    ..   . .||..|.|  .||.|| ...||.. ..         ||.||||||.|   ||.| . . .. . .  ||.
edygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfn

AVWHPD
.. || 
ssphpy

subfamily_PPP4C_pd Subfamily PPP4C 201-487 3.2e-75 246.0 In-house 4-285 (288) alignment
Range on Protein: 201-487
Range on HMM: 4-285/288.0
EEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRI
....|. |. | |...   ..   | ..| .   .. |  |     ||||| ||||||.|..|...|   ||. |.| ||||||| .| | .| .||...
drqieklrrcelikeeevkalcakareilveesnvqrvdsp....vtvcgdihgqfydllelfkvggd.vpetnylflgdfvdrgfysvetfllllalkv

LYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
 ||.   . |||||| .. ..|||  |.  || | .|  . |||.. |.|. .|..||..||||| | .  ||||.| |||  . |.|| .|.|||.|| 
rypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpe

PRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAV
   |   | ||.|  || |...|| |.|...|..|.|..  ||| .  . | .|..|||||| . ||. | . | ..|. .|. |.|.
daegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 194-482 1.6e-74 243.6 In-house 5-289 (298) alignment
Range on Protein: 194-482
Range on HMM: 5-289/298.0
NITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSPENpYVFNGDFVDRGSFSCEVIL
..  |...  ... .  ..|...   ... .| ....| .|| .|  |    ..|||| |||. |.| .|. .| |  .| |.| ||.||||... |||.
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnleviv

TFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY-TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCE
 .|||.. ||| ||. ||||| | .|..|||  |.| .|   ..   | .|.|.|||  .| ..|| .|||| |.  ..||.||.. |  ...|| |  .
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWADPGPR-PGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFT
||||||     |  .. || . .|| |  |..||. .. |..|.| .  .|||   . | .||||||.||.|. |  |.... ..|.  |.
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfe

PPP_4 247-439 9.3e-70 227.7 In-house 2-197 (197) alignment
Range on Protein: 247-439
Range on HMM: 2-197/197.0
TVCGDTHGQFYDV-LNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYN
||.||.|||..|. |..... |.||.|. |||.||.||||..|.||.|..||. . ||. ... ||||||. .|..|||. ||. |....... ...|..
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

SLPLGHVIEDKILVVHGGLFSRDGvTLDELRKIDRFCQPP-EEGLMCEL-LWADPG-PRPGrW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
 ||| ..|..|.|||||||..    .||....|.|... | ||.....| ||.||     | . .| || || ||||.|..|||.|||||.|||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshelk

subfamily_PPP6C_pd Subfamily PPP6C 210-488 3.3e-69 226.2 In-house 12-285 (290) alignment
Range on Protein: 210-488
Range on HMM: 12-285/290.0
QETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMS
 . . ..   ..  .  ||| .  ..  |. |    .||||| ||||||....|   |.  |.. ||| ||||||| .| | .  .|. .. ||.   . 
ckylpendlkklcdlvldllleesnvqpvssp....vtvcgdihgqfydleelfrtggq.vpdtsyvflgdfvdrgyysletftrlltlkakypdritll

RGNHESERMNEMYGFTGEVKAKYT-SQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWPSM
|||||| .. ..|||  | . ||  ...   .|.|.. |... .|....| ||||| | |  |||..| |.|  . |..| .|.|.|.||        | 
rgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsp

RGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDAVW
||.|  ||  .||.|.. |||||..|.|.. |||..   | | .|..|||||| . ||  . ..| .. | ..  |.|| 
rgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavp

PPP_2 247-439 9.9e-69 224.0 In-house 2-198 (198) alignment
Range on Protein: 247-439
Range on HMM: 2-198/198.0
TVCGDTHGQFYDVlNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK-AKYTSQVMDLFTEVYN
|||||.|||..|. .|.  || ||||. |.|.||.||||..|.||.|..||. . ||..... ||||||...|..|||. ||.  |....|.. ..||..
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

SLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPPEEGLMCEL-----LWADPGPRPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
 |||...|..|.|||||||...   .||. .|..|... ||||....|     |. ..  . .  .| ||.|| ||||.|...||.|.|||.||.||.|
lLplaalidekvlvvHGGlsee.iklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 210-484 1.4e-67 221.1 In-house 5-280 (284) alignment
Range on Protein: 210-484
Range on HMM: 5-280/284.0
QETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP-----SPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPN
|. ...|  |.. . | .|. | .   ....|    ....|| |||| |.| ...||| |     . |. |.| ||.|||| || |||. ..||..|.|.
qkllkekelielcyrarelfwkeklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

SFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGR
  |. ||||||  .|  |||  | | .|. .. . |   .|..||  |...||. .|||. | | . |..| |..| .. |. |....| ||||  .   
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaeveg

W-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
.  | ||.|  ||..  |.||.. .|.|..|.|..  .|||   | | .|||||| || |. | .| ... ..|.  || .
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl

PPP_5_Dcr2 247-439 2.4e-67 219.8 In-house 2-199 (199) alignment
Range on Protein: 247-439
Range on HMM: 2-199/199.0
TVCGDTHGQFYDVLNIFELNG-RPSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAK-YTSQVMDLFTEVY
|||||.|||..|.| |.. .| .||.|. |||.||.||||..|.||.|. ||. ..||. ... |||||.| .||.|||| ||. | . ..... ...|.
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NSLPLGHVIEDKILVVHGGLFSRDGvTLDELRKIDRFCQPP-EEGLMCEL-LWADPG-PRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMK
. ||| ..|..|.|||||||..    ....|.||.|... | |.| ...| ||.||     | . .| || || ||||.|..|||.|||||.|||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 244-481 1.3e-66 217.6 In-house 33-269 (280) alignment
Range on Protein: 244-481
Range on HMM: 33-269/280.0
NKLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEV
  ..|||| |||. |.| .|.  . | |.. |.| ||.||||..  ||||  |||.. |||.|.. |||||  ..|. |||  ||| .|. .. . | |.
apvavcgdlhgqytdllrlfarvsfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqel

YNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEG
..||||  ..  .||..|||| |.. |.||.|... |  ....| |  .||||||  .   |  . ||.  .|| .. |.. |. .. |..| |.. ..|
ldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdg

YEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
||   | | .|.||||.|.... |. | . . . |.  |
yeffadkklvtvfsapkylgefdnsaavlivderlivsf

subfamily_PPG1_pd Subfamily PPG1 202-486 5.5e-64 209.3 In-house 3-295 (300) alignment
Range on Protein: 202-486
Range on HMM: 3-295/300.0
EMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGrPSPENPYVFNGDFVDRGSFSCEVILTFLAYRIL
| .|...| | . .    ..     .|| |   . ..| |    .|| || ||||||||.||.. | . |.  |.| ||.|||| .| | |  ... .. 
ecleklqkaellpevtvkeltdklkellvkesnvieirsp....vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklr

YPNSFFMSRGNHESERMNEMYGFTGEVKAKY--TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPG
||    . |||||| .. ..||| .|.  ||   |.| . .||... | |  .|...| .||||| | .  ..|... .||| . |.|| ...|||.|| 
ypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpe

-------PRPGRW-----PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
        .| |       | ||.|  .| |....||. |... .||.|..  |||..  |.|  |..|||||| . ||| . . | . .|  |  ...
ennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyee

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 218-484 9.2e-64 208.4 In-house 13-274 (281) alignment
Range on Protein: 218-484
Range on HMM: 13-274/281.0
TIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESER
 .... ..  .. .  .|...  |     .| || |.|| |. ..||| ||. ||. .|| ||.||||  | ||.. .....| |..  .. |||||  .
ienvireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFG
.| .|||  | . ||  ..  || . .| ||.   |. ..|..|||| | . ..|||||.. . ..... ||. .|||||| ..   |  |.||..  ||
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

PDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
 .. ..   . .. |.||.| .  .||||    | ||.||.||||..  | .| ... ..|. .. ..
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval

subfamily_PPP7C_pd Subfamily PPP7C 181-380 8.8e-63 205.3 In-house 2-201 (383) alignment
Range on Protein: 181-380
Range on HMM: 2-201/383.0
VPDSYTGPSFEMgNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPESNKLTVCGDTHGQFYDVLNIFELNGRPSPENPYVFNGD
|.|||||| ...  .||. ||...|.|......| || ..||  | . |..||... |    |...||||| ||.. |.| |.  || ||.|||||||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKY---TSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFsrDGVTLDELRK
|||||. | |..| .||. ..||..... |||||   .|  |||. ||. ||   ..... |. .|.  |||. .|..|||.||||.   |   |. | |
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis..dktdlelldk

IDR
|.|
ier

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 207-484 3.6e-62 202.9 In-house 4-279 (287) alignment
Range on Protein: 207-484
Range on HMM: 4-279/287.0
FRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSF
.   ...  |  ...|  . ..|. ||.| .|. |    .|..||.|||. |.|.||.  |.. |.  |.| ||.||||. | ||.| .....|.||.. 
ygvldafsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkv

FMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPP--EEGLMCELLWADPGPRPG-
 . ||||| ...|..|||  |.| |. ...   | .|.. |||   .. .|| .|||. |..  .||.|. . .  .|   .|||. .||||||      
hllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdakt

-RWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
 .   .|.    ||     ..|.. ...|..|.||..||||.   | ...|.|||| |. .  | || ....| || .|...
felnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 209-481 1.4e-61 201.4 In-house 20-288 (299) alignment
Range on Protein: 209-481
Range on HMM: 20-288/299.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFM
  ......  ...  .| . . . .|| .|  |    . |||| |||. |.| ||. .| | |.  ..| ||.||||    |.|  .|...| ||. |||
ltksvkeqelqtlcavaksvfasqaslleveap....iivcgdihgqysdllrifdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperffm

SRGNHESERMNEMYGFTGEVKAKYTSQ-VMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-P
 |||||   .| .|||  |.. .|.|  .  .| . .. .||  .|  .||..|||| |    ||| ||.. |  .||.  |  .||||||      | .
lrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwla

SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
 .||    ||.|. .. ... .. |. |.|.. ..|||   . | .|||||| || |. |  | . . ..|   |
nvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctf

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 274-484 1.8e-61 201.1 In-house 102-312 (317) alignment
Range on Protein: 274-484
Range on HMM: 102-312/317.0
PYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLD
 |.| ||.|||| || ||.. ..|...|||.  |. ||||||  .|  |||  ||| .| ... . |  ..| |||  |...||| .|||. | . . |.
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldlk

ELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
.| |..| .. |. |....| |||| ..   . .| ||.|  ||..  |.||.. .|.|..|.|.. |.|||   | | .||||||.|| |. | .| ..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

LTKDLEPKFTQF
. |.|.  .. .
vdkklkisinvl

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 211-481 6.8e-60 195.8 In-house 21-289 (297) alignment
Range on Protein: 211-481
Range on HMM: 21-289/297.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSR
. | ..  ...| .| |....  |. .|  |    . |||| |||| |.| .|   | | |   |.| ||.|||| || | |. .|||.. .|  .|. |
kviteervlklldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllr

GNHESERMNEMYGFTGEVKAKYTSQVM-DLFTEVYNSLPLGHVIEDKILVVHGGLFS--RDGVTLDELRKIDRFCQpPEEGLMCELLWADPGP-RPGRWP
|||| | .|..|||  |.. .| |  |   | .|.| |||  .| .|||..||||     . .||| ||||.|  .  .|.|...||||||     |   
gnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfme

SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
  ||.|  || |   .   . .| |. |.|.. ..|||.    | .|||||| || |. |  ||..  . |.  |
nqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 202-483 3.3e-58 190.0 In-house 5-285 (290) alignment
Range on Protein: 202-483
Range on HMM: 5-285/290.0
EMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRIL
| ....   ...  |  ..||  . ..|. ||.| .|  |    ... || |||. ..|. |.  |.| |.  ..| ||.||||. | || | .. |.|.
ehllkygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgyp.pkvkflflgdyvdrgakslevslllfcykir

YPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDR--FCQPPEEGLMCELLWADPG
|...  . |||||  ..| .|||  |.  | .|..   . .|.. |.|   .. ||| .|||. |..  . . |. . .       .|||. .|||||| 
yskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwadpt

P---RPGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQ
       .   .|.    || .   ..|..  |.|..|.||.||||..   | |..|.|||| |. .  | || .|... || ... 
rdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv

subfamily_PPZ_pd Subfamily PPZ 211-486 1.4e-55 181.9 In-house 23-293 (300) alignment
Range on Protein: 211-486
Range on HMM: 23-293/300.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVripeSNKLTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSR
  ....  .||   | .|.   |.| ..    |  . . || |||. |.| .|   | | | . |.| ||.||||  | | || .|.|.| ||. ||. |
vclknseilqicikarelflaqpallel....spsvkivgdvhgqyadllrlftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllr

GNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWPS-MR
||||   .  .|||  |.| .   ..   | . .|.|||  ..  ||..||||| |    ..||.|.. |  . |. ||. .|||.||   .  |    |
gnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhggl.spvlnsmdeirhvvrptdvpdfglindllwsdptdssnewedner

GTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
|    .     ..||..  . |. |.| . |.|||.  |   .|.||||||| .. | || ..... |   |  .| 
gvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 220-481 1.7e-55 181.4 In-house 10-268 (284) alignment
Range on Protein: 220-481
Range on HMM: 10-268/284.0
QILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPSPENpYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMN
 .|. |.... | | | .|  |    . .||| |||| |.| .|. || |   | |.| ||.||||    | || ..||....|| ||| |||||   .|
tllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

EMYGFTGEVKAKYTS-QVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPE-EGLMCELLWADPGPR-PGRWPSMRGTGLQFG
..|||  |.. .|    |.  |  |.  .||  .. ..||..|||. |.    . .|| | |  . || . |  ..||.||     |  |  ||    ||
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

PDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKF
 |  ...|.. .. |..|.|.. ..|||.  . . .|||||| || |. |  | . . |.|   |
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsf

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 246-475 2e-52 171.3 In-house 49-280 (307) alignment
Range on Protein: 246-475
Range on HMM: 49-280/307.0
LTVCGDTHGQFYDVLNIFELNGRPsPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK---AKYTSQVMDLFTE
  | || |||| |..|.| | ||| ||  ||| ||.|||| .| |.|| ...|.| ||..  . |||||  |.|. |||  |.     |   ..  ||  
cvvvgdlhgqfndlinmfillgrp.petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqr

VYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRWP-SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEE
..| ||.  .|  |||..|||| |     |||||.  .  . |  |.. ..||||| |    |  | ||.|. || ..  .      ..|.||.|.|  .
cfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfd

GYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTK
|| |    | ||||||| ||.   | |. . . .
gywvlsgrklitifsapmycnfyknagcvlkvde

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 245-484 7e-52 169.6 In-house 34-272 (280) alignment
Range on Protein: 245-484
Range on HMM: 34-272/280.0
KLTVCGDTHGQFYDVLNIFELNGRpSPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVY
 . | || | |. |.  .|.| ||  ||.  .| ||.||||    ||.. ... .| | .  .. |||||.  .|..|||  |.. ||   .   |  ..
pikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscf

NSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQPPEEGLMCELLWADPGPRPGRW-PSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGY
| .|.  .|  ..|..|||| | . . || .|.| | |.| . ||. .|||.||  .   |  |.||    ||  . .|  .  .. |.||.|.. ..||
nrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgy

EVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
|.    . ||.|| |||| |. |  | . |  .|.  | |.
emmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqql

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 274-478 4.9e-49 160.2 In-house 121-325 (339) alignment
Range on Protein: 274-478
Range on HMM: 121-325/339.0
PYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLD
 |.| ||.|||| || ||.. . | .. ||.  .. ||||||  .|  |||  ||. .| .|. . | ...| .|.  ||.. |...|||. |    ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

ELRKIDRFCQPPEEGLMCELLWADPGPR-PGRWPSMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFIT
..  . |  . |. |.. .| |||| |   |  || ||. . |||   . ||.. .|...|| |.. |.|||.    . .||||||||| |  |  | ..
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LTKDLE
. | |.
idkklk

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 209-474 6.2e-41 133.5 In-house 3-288 (302) alignment
Range on Protein: 209-474
Range on HMM: 3-288/302.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP----------SPENPYVFNGDFVDRGSFSCEVILTFLAY
.... .|.  .... .  .||.|  .|...  |    .|. || |||| |.. |.  .               .. .|| ||.||||| | | |   .|.
rkkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfal

RILYPNSFFMSRGNHESERMNEMYGFTGEVKAK----YTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPP-EEGLMCEL
..|||. . . |||||.. .|  ||| .|.. .     . .. . | ||.  .||  .. .||| ||||.  .   .|....||.|  .   |. |  .|
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdl

LWADPGPR-----PGRWP-----SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLT
|.|||        . . |      .||  . |     ... .. ||||..|.| |  ||.    | | .||||||.| ... |||| . . 
lfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 209-474 7.3e-41 133.3 In-house 2-287 (302) alignment
Range on Protein: 209-474
Range on HMM: 2-287/302.0
KQETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRP----------SPENPYVFNGDFVDRGSFSCEVILTFLAY
.... .|.  .... .  .||.|  .|...  |    .|. || |||| |.. |.  .               .. .|| ||.||||| | | |   .|.
rkkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfal

RILYPNSFFMSRGNHESERMNEMYGFTGEVKAK----YTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRdGVTLDELRKIDRFCQPP-EEGLMCEL
..|||. . . |||||.. .|  ||| .|.. .     . .. . | ||.  .||  .. .||| ||||.  .   .|....||.|  .   |. |  .|
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdl

LWADPGPR-----PGRWP-----SMRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLT
|.|||        . . |      .||  . |     ... .. ||||..|.| |  ||.    | | .||||||.| ... |||| . . 
lfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 246-484 1.9e-39 128.9 In-house 9-253 (263) alignment
Range on Protein: 246-484
Range on HMM: 9-253/263.0
LTVCGDTHGQFYDVLNIFELNGRPSpENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTS-----QVMDLF
. .|||||||. |.| ||.  |  . .  |.| ||.|||| .| |||. ... ..  |  ... ||||| . .|. |||  |.| ..        | . |
inicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TEVYNSLPLGHVIEDKILVVHGGLfSRDGVTLDELRKIDRFCQP-PEEGLMCELLWADPGPRP-GRWP-SMRGTGLQFGPDITKQFLEHNNLKLLIRSHE
 .|.. .||  ..  .||..|||. |    .||..| |    .      | |.||||||     |  |  .|     ||     .. .. .. |..|.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

MKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQF
. | || .  | . ||.|||  |  .. |  | . . | ||  | |.
vveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvql

Metallophos Calcineurin-like phosphoesterase 245-439 3.9e-38 124.7 Pfam-A 2-199 (200) alignment
Range on Protein: 245-439
Range on HMM: 2-199/200.0
KLTVCGDTHGQFYDV---LNIFELNGRPSPENPYVFNGDFVDRGSFSCEVILTF--LAYRILYPNSFFMSRGNHESERMNEMYGFTGEVK----------
. .|.||.||...|    |.|.. .. ... ....|.||.||||  | |..  .  |.. .|.|. .|. ||||||  .|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------AKYTSQVMDLFTEVYNSLPLGHVIEDKILVVHGGLFSRDGVTLDElrkidrfcqppeeglmcellwadpgprpgrw
                         ...  . . . |... ||| . .. |||..||.|.|..| ..|.                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

psmrgTGLQFGPDITKQFLEHNNLKLLIRSHEMK
      .  |||| .  .|| ....|..|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk

subfamily_PPPLV_pd Subfamily PPPLV 247-475 5e-36 117.5 In-house 27-277 (290) alignment
Range on Protein: 247-475
Range on HMM: 27-277/290.0
TVCGDTHGQFYDVLNIFELNGRP---SPENPYVFNGDFVDRGSFSCEVILTFLAYRILYPNSFFMSRGNHESERMNEMYGFTGEVKAKYTSQ---VMDLF
 | || ||.. |.  . .   |         ..| ||.|||| || |.|  .|| ..|||  ... ||||| | . | . . || . |.  .   | . |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

TEVYNSLPLGHVIEDKILVVHGGLF--SRDGVTLDELRKIDRFCQPPEEG--LMCELLWADPGP------------RPGR-WPSMRGTGLQFGPDITKQF
..|.. |||  ||..|.. ||.|.   .  .  .  ...|    . . .|  |  ..||.||                |    . ||||  |. |  ..|
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

LEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQmGNKGAFITLTK
|..|||. ..|.||.||.|... ..|. .|.||. .|| .  |. | | . |
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk

subfamily_PPP7C_pd Subfamily PPP7C 390-486 6.3e-34 110.3 In-house 237-334 (383) alignment
Range on Protein: 390-486
Range on HMM: 237-334/383.0
MCELLWADPGPRPGRWPS-MRGTGLQFGPDITKQFLEHNNLKLLIRSHEMKEEGYEVAHDGKCITIFSAPNYCDQMGNKGAFITLTKDLEPKFTQFDA
. ..||.||  . | .|  .||.|  ||||.||..|.. |||||||||| | ||||..|| |..||||| || ..  |.||.. |.|||.|.. |. |
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqa

PPP5 PPP5 TPR repeat region 142-238 2.1e-28 88.6 Pfam-A 1-95 (95) alignment
Range on Protein: 142-238
Range on HMM: 1-95/95.0
KLKGVEKMIHQLAFAKAIAVEHNTISAVEKLrqNLENLTVPDSYTGPSFEMGNITKEFVEEMVEQFRKQETIHKKYTIQILLMAYDLLRKLPSLTDV
|||  ||.....|| |||.|... .|..|..  ..|.... |.|.|| .| ...|.|||.|..|.|.||. .|||. .||||   .||.||||| ..
KlkeCeklvkkiaFekAIevdeekrsvaesi..diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei

TPR_11 TPR repeat 43-99 1.4e-16 49.5 Pfam-A 10-68 (69) alignment
Range on Protein: 43-99
Range on HMM: 10-68/69.0
GNKAFKNKSFHAAIDAYTEAIDLDP-QPAYYCNRAFAYLKTE-AWGAAVNDANEALKLD
||..||.. .. ||.||..|..|||  . .|.|.| ||||    . .|. |...||.||
GnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleld

TPR_11 TPR repeat 87-134 9.7e-09 24.4 Pfam-A 21-69 (69) alignment
Range on Protein: 87-134
Range on HMM: 21-69/69.0
AAVNDANEALKLDDRFIKAYYRRATANMNLG-HLKASRRDFEAVLKVKP
 |.   ..||.||.   ..||..| | ..|| . .. ..|.| .|.  |
eAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP

TPR_9 Tetratricopeptide repeat 78-141 4.5e-07 19.1 Pfam-A 4-67 (73) alignment
Range on Protein: 78-141
Range on HMM: 4-67/73.0
AYLKTEAWGAAVNDANEALKLDDRFIKAYYRRATANMNLGHLKASRRDFEAVLKVKPSDKDAQQ
.||  | . .| . ..  | |.      .. |. . . ||.| | ..|.|| |.. |.. ||..
iylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcpdapdael

TPR_16 Tetratricopeptide repeat 75-136 1.1e-06 18.8 Pfam-A 3-64 (65) alignment
Range on Protein: 75-136
Range on HMM: 3-64/65.0
RAFAYLKTEAWGAAVNDANEALKLDDRFIKAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
.| |.|.   . .|.. ...||.|. .   |....| | . .|.|.|... ..| |.  |.|
lArallraGdydeAlaaleaalalaPeaaeallllaeallrqgrldaAaallraalalaPdd

TPR_1 Tetratricopeptide repeat 43-68 1.2e-06 17.6 Pfam-A 8-33 (34) alignment
Range on Protein: 43-68
Range on HMM: 8-33/34.0
GNKAFKNKSFHAAIDAYTEAIDLDPQ
||  .|.. .  |...| .|. |.|.
GnaylklgkydeAleyyekALelnPn

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 211-270 1.4e-06 20.7 In-house 7-62 (317) alignment
Range on Protein: 211-270
Range on HMM: 7-62/317.0
ETIHKKYTIQILLMAYDLLRKLPSLTDVRIPesnkLTVCGDTHGQFYDVLNIFELNGRPS
. ...|  |.. . | .|. | |   ....|    .|..|| |||| |.| ...||| | 
dlfkekelielcyrarelfwkeplkleleap....vtivGdihGqfedllalldlnGwpl

subfamily_YNL217W_pd Subfamily YNL217W 244-370 2.7e-06 20.1 In-house 10-142 (235) alignment
Range on Protein: 244-370
Range on HMM: 10-142/235.0
NKLTVCGDTHGQFYDVLNIFE-LNGRPSPENPYVFNGDFVDRGSFSCEVIlTFLayrilYPNSFFMSRGNHESERMN------EMYGFTGE---VKAKYT
 .| | || || . .......  .|   ..   |. ||....|  | ||.  ..       .     .||||   .       .  |..      | .. 
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevv.syv.....rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfl

-SQVMDLFTEVYNSLPLG-HVIEDKILVVHGGLFSRDGV
 |.. .  .| . .|.   ..  |..||||.|| . . .
esklskadmeyarelgfsldipsdellvvhaGlvpgkfl

TPR_2 Tetratricopeptide repeat 104-136 3.4e-06 16.5 Pfam-A 2-34 (34) alignment
Range on Protein: 104-136
Range on HMM: 2-34/34.0
KAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
.|.|... | ..||...  ...|| .|.  | .
ealynlGlayyklgdyeeAleafekAleldPnn

TPR_1 Tetratricopeptide repeat 104-136 6.1e-06 15.4 Pfam-A 2-34 (34) alignment
Range on Protein: 104-136
Range on HMM: 2-34/34.0
KAYYRRATANMNLGHLKASRRDFEAVLKVKPSD
||.|... | ..|| ..    ..| .|.. |..
kalynlGnaylklgkydeAleyyekALelnPnn