Gene MbreHP1-Un-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP108_AA protein Get Run
MbreP108_AA_9-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PMU1_pd Subfamily PMU1 10-217 9e-99 319.9 In-house 2-232 (233) alignment 
Range on Protein: 10-217
Range on HMM: 2-232/233.0
HMEVSFVRHGEGYHNLAATKmgHGCTCLNDMPAPDCPYINPDIVDPALTSLGEDQARaNTGT------AATLG-VEHV-YCSTLQRAIQTALLGFEAV--
......|||||||||||..|  .|...|....|......|..|.|..|||||.||.| .||.      |..|| .||| ..|||.||..|||..||||  
ykllilvrhGeGyhnlailk..yGmekldaywallsgdengeildskltslGkdqvr.rtGsnvllpmakqlGmlehvffsstlrraletalesfeavla

--------PNVRFMAIESAREQSGMHHCDQRRTRTAIHQQFPDLQLE----------PDLPEADELWKTE-REPKVALAARCTATLRTLAADPSPR---V
        ..|....|||.||..|.|.||.|..|.||.....||.||          |||||.||||||. ||.||.|..|..|||..||||.|..   |
etqelpagtkvstriieslretlGshtcdkrvarsaivdeyqdlslesghtvhwqyvPdlPeddelwktdhretkveldkrtlatlfelaadlsseekfv

ALVTHSSFLLTLFQAIlvledvpDHLRTW-FSTGEVRTLCL
|||||||.||.|..|.       ||||.. ..||.|..|.|
alvthssvllsllral.......dhlriynldtGkvvalvl
0051064 Phosphoglycerate mutase-like 11-215 7.3e-29 93.8 In-house 4-216 (241) alignment 
Range on Protein: 11-215
Range on HMM: 4-216/241.0
MEVSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdIVDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGFEAVPN--VRFMA
... .||||| ..|..    |                      |. || ||. ||||     |   . ...||.|.|.|||||| . .|| ..  ...  
krlyLvRHGesewnaegrlqg....................wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvv

IESAREQsgMHHCDQRRTRTAIHQQFPDLQLEPDLPEADELWK------------------------TEREPKVALAARCTATLRTLAAD---PSPRVAL
 .  ||.   . .....|.. |...||...   .  . | ..                            |.  ..|||. . |. |.|    .  .|..
dprlrEi..dfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlv

VTHSSFLLTLFQAILVLEdVPDHLRTWFSTGEVRTL
|.|. .. .|.. .| |  . ..||  . .|.| .|
VsHggvirallayllglp.leellrlnlpngsvtvl
0048955 Phosphoglycerate mutase-like 13-211 1.6e-28 92.7 In-house 3-209 (240) alignment 
Range on Protein: 13-211
Range on HMM: 3-209/240.0
VSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdIVDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGFEAVPN--VRFMAIE
. .||||| ..|..    |                      |. || ||. ||||     |   . ...||.|.|.|||||| . .|| ..  ...   .
lyLvRHGesewnaegrlqg....................wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdp

SAREQsgMHHCDQRRTRTAIHQQFPDLQLEPDLPEADELWK------------------------TEREPKVALAARCTATLRTLAAD---PSPRVALVT
  ||.   .......|.. |...||...      . | ..                          . |.  ..|||. | |..|.|    |. .|..|.
rlrEr..dfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVs

HSSFLLTLFQAILVLEdVPDHLRTWFSTGE
|. .. .|.. .| |  . . ||  ...| 
Hggvirallayllglp.leeilrlnipngs
0036777 Phosphoglycerate mutase-like 11-214 1.6e-22 72.8 In-house 3-214 (247) alignment 
Range on Protein: 11-214
Range on HMM: 3-214/247.0
MEVSFVRHGEGYHNLaatkmghgctclndmpapdcpyINP--DIVDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGFEAVP--NVRF
. . .||||| ..|.                       .   . .|. || ||. ||.|     ..  | ...||.|.|.|||||| . .|| .  ... 
krlyLvRHGetewna......................egrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpv

MAIESAREqSGMHHCdQRRTRTAIHQQFPDLQLE----------PDLPEADELWK--------------TEREPKVALAARCTATLRTLAAD---PSPRV
   .  ||  ... . . .|.. |....|...            | | . .||.                . |.  ...||. ..|. |.|    .  .|
vvdprLrE.rdyGal.egltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenv

ALVTHSSFLLTLFQAILvLEDVPDHLRTWFSTGEVRT
..|.|. .| .|.. .|   .. | || ....| . .
lvVsHggvlrallayll.glsledilrlnlpngsitv
0036887 Phosphoglycerate mutase-like 11-214 2.3e-22 72.1 In-house 2-182 (202) alignment 
Range on Protein: 11-214
Range on HMM: 2-182/202.0
MEVSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdIVDPALTSLGEDQARANTGTAATLGVEHVYCSTLQRAIQTALLGFEAVPnVRFMAIESA
. . .||||| ..|..   .|                     .|. || ||. ||||     | | . .||.|.|.|||||| . .|| . .     .  
trlyLvRHGetewnvegrlqg....................dldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealg.lpvivdprl

REQsgMHHCDQRRTRTAIHQQFPDLQLEPDLPEADELWKtEREPKVALAARCTATLRTLAAD-PSPRVALVTHSSFLLTLFQAILVLEDVPDHLRTWFST
||.   . . . .| . |....|...       .|  .  . |. ....||. |.|..|.|  .. .|..|.|. .| .|. ..| |..   .   ....
rEi..dfgalegltleeiaekypeelaawlrdpydfrpp.ggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpn

GEVRT
| | .
gsvtv
0037864 Phosphoglycerate mutase-like 10-214 9.1e-22 70.0 In-house 7-194 (211) alignment 
Range on Protein: 10-214
Range on HMM: 7-194/211.0
HMEVSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdIVDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGFEAVPN--VRFM
 . . .||||| ..|..    |                     .|. || ||. ||||     |   | ...||.|.|.|||||| . .||..   ..  
mtrlyLvRHGetewnaegrlqg....................wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpve

AIESAREqsGMHHCDQRRTRTAIHQQFPDLQLEPDLPEADELWKtEREPKVALAARCTATLRTLAAD---PSPRVALVTHSSFLLTLFQAILvLEDVPDH
  .  ||    ..  . .| . |....|...       .|  .  . |.  ...||. ..|..|.|    .  .| .|.|. .| .|.  .|   .. ..
vdprlrE..rdfgalegltleeiaekypeelvawlrdpydfrpp.ggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayll.glsleel

LRTWFSTGEVRT
|| ....| | .
lrlnlpngsvtv
0049178 Phosphoglycerate mutase-like 11-212 1.7e-21 69.4 In-house 4-211 (243) alignment 
Range on Protein: 11-212
Range on HMM: 4-211/243.0
MEVSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdIVDPALTSLGEDQARANTGTAA--TLGVEHVYCSTLQRAIQTALLGFEAVP--NVRFMA
... .||||| ..|..    |                     .|. || ||. ||||     |   | ...||.|.|.|||||| . .|| .  ...   
trlyLvRHGetewnaegrlqg....................wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvv

IESAREqSGMHHCDqRRTRTAIHQQFPDLQLEPDLPEADELW----------------------KTEREPKVALAARCTATLRTLAAD---PSPRVALVT
 .  ||  ... ..  .|.. |....|...        |  .                        . |.  ..|||. ..|..|.|.   .  .|..|.
dprLrE.rdfGale.gltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVa

HSSFLLTLFQAILVLeDVPDHLRTWFSTGEV
|. .. .| ...| | .. ..|| ....| |
Hggvirallalllgl.pleellrlnlpngsv
0035570 Phosphoglycerate mutase-like 13-200 4.6e-20 64.5 In-house 2-158 (219) alignment 
Range on Protein: 13-200
Range on HMM: 2-158/219.0
VSFVRHGEGYHNLaatkmghgctclndmpapdcP----YinpdivDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGfeavpNVRFMA
. .||||| ..||                    .           |. || .|. ||||     |   . . .||.|.|.|||||| .      ..    
lyLvRHGetewnl....................egrlqg......dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.....glpvei

IESAREQSgmHHCDQRRTRTAIHQQFPDLQLEPDLPEADELWKtEREPKVALAARCTATLRTLaaDPSPRVALVTHSSFLLTLFQAILvleD--VP
 .  ||..  .   . .|.. |....|...       .|  .  . |.  ...||. . |..|   .  .|..|.|. .. .|.  .|   .  . 
dprLrEid..fgdlegltldeiaekypeelaawlrdpydyrpp.ggEsladvvaRvlpaleel..edgenvlvVsHggvirallayll...glple
0043909 Phosphoglycerate mutase-like 11-216 4.7e-20 64.6 In-house 3-220 (249) alignment 
Range on Protein: 11-216
Range on HMM: 3-220/249.0
MEVSFVRHGEGYHNLAatkmghgctclndmpapdcpYINPDIVDPALTSLGEDQARANTGTAA--TLGVEHVYCSTLQRAIQTALLGFEAVPN--VRFMA
... .||||| ..|..                     .  ...|. || ||. ||||     .   . ...||.|.|.|||||| . .|. ..  .    
krlyLvRHGetewnae....................grfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvev

IESAREQsgMHHCDQRRTRTAIHQQFPDLQLEPDL------------------------------PEADELWKteREPKVALAARCTATLRTLAAD---P
 .  ||.   . . . .| . |....|...                                   |..| . .   |.  ...||. ..|. |.|    .
dprLrEr..dfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppg..gEsladvvaRvlpaleellarllkd

SPRVALVTHSSFLLTLFQAILvLEDVPDHLRTWFSTGEVRTLC
  .|..|.|. .| .|.  .|   ...| || ....| . .| 
ggnvliVaHggvlrallayll.glsledilrlnlpngsitvle
His_Phos_1 Histidine phosphatase superfamily (branch 1) 13-186 5.1e-20 65.0 Pfam-A 2-155 (158) alignment 
Range on Protein: 13-186
Range on HMM: 2-155/158.0
VSFVRHGEGYHNLAATkmghgctclndmpapdcpyINPDIVDpALTSLGEDQARANTGTAA--TLGVEHVYCSTLQRAIQTALLgFEAVPNVRFMAIESA
. .||||| ..| .                     .. .. .  ||  |..|||.     .   | ...||.|.|.|||||| . . .. ....   .  
lylvRHGesewnkegr...................lqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lleeldipiikeprL

REQSGmHHCDqRRTRTAIHQQFPdlqlepdlpEADELWKT--------EREPKVALAARCTATLRTLA--ADPSPRVALVTHSSFL
||..    .. ..... ....||         |..| ||.        | |   ....|....|..|.   |.. .| .|.| ..|
rerdf.gewe.glpkeevkeefp.........eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 13-186 5.1e-20 65.0 In-house 2-155 (158) alignment 
Range on Protein: 13-186
Range on HMM: 2-155/158.0
VSFVRHGEGYHNLAATkmghgctclndmpapdcpyINPDIVDpALTSLGEDQARANTGTAA--TLGVEHVYCSTLQRAIQTALLgFEAVPNVRFMAIESA
. .||||| ..| .                     .. .. .  ||  |..|||.     .   | ...||.|.|.|||||| . . .. ....   .  
lylvRHGesewnkegr...................lqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lleeldipiikeprL

REQSGmHHCDqRRTRTAIHQQFPdlqlepdlpEADELWKT--------EREPKVALAARCTATLRTLA--ADPSPRVALVTHSSFL
||..    .. ..... ....||         |..| ||.        | |   ....|....|..|.   |.. .| .|.| ..|
rerdf.gewe.glpkeevkeefp.........eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvl
0039931 Phosphoglycerate mutase-like 13-212 2.1e-19 62.3 In-house 2-170 (219) alignment 
Range on Protein: 13-212
Range on HMM: 2-170/219.0
VSFVRHGEGYHNLaatkmghgctclndmpapD----CpyinpdivDPALTSLGEDQARANTGTAAT--LGVEHVYCSTLQRAIQTALLGfeavpNVRFMA
. .||||| ..|.                  .             |. || .|. ||||     .   | . .||.|.|.|||||| .      ..    
lyLvRHGetewnv..................egrlqg........dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.....glpvei

IESAREQSGMHHcdQRRTRTAIHQQFPDLQLEPDLPEADELWKTeREPKVALAARCTATLRTLAAdpSPRVALVTHSSFLLTLFQAILvleD--VPDHLR
 .  ||..      . .| . |....|...       .|  .    |.  ...||. . |..|.|    .|..|.|. .. .|.  .|   .  . . ||
dprLrEidfgdl..egltleeiaekypeelaawlrdpydyrppg.gEsladvvaRvlpaleella..genvlvVsHggvirallayll...glsleeilr

TWFSTGEV
  ...| |
lnlpngsv
0053607 Phosphoglycerate mutase-like 11-197 1.6e-18 59.5 In-house 2-158 (191) alignment 
Range on Protein: 11-197
Range on HMM: 2-158/191.0
MEVSFVRHGEGYHNLAATKMGhgctclndmpapdcpyinpdivDPALTSLGEDQARANTGTAA--TLGVEHVYCSTLQRAIQTALLGfeavpNVRFMAIE
... .||||| ..|..    |                      |. || ||. ||||     |   | . .||.|.|.||.||| .      .. ..  .
trlyLvRHGetewnaegrlqg......................dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.....glpvevdp

SAREQSGMHHcdQRRTRTAIHQQFPDLQLEPDLPEADELWKtEREPKVALAARCTATLRTLAAdpSPRVALVTHSSFLLTLFQAILVLE
  ||..      . .|.. .....|...        |  .  . |.  ..|||. ..|..|.|    .|..|.|. .. .| . .| | 
rlrEidfgdw..egltleelaekypeelaawlrdpldyrpp.ggEsladvaaRvlpaleella..ggnvlvVaHggvirallayllglp
0050036 Phosphoglycerate mutase-like 11-194 2.5e-14 45.5 In-house 1-145 (171) alignment 
Range on Protein: 11-194
Range on HMM: 1-145/171.0
MEVSFVRHGEGYHNLAATKMGHgctclndmpapdcpyinpdiVDPALTSLGEDQARANTGTAatlGVEHVYCSTLQRAIQTALLGFeavpnVRFMAIESA
|.. .||||| ..||.    |.                    .|. || ||. ||||         . .||.|.|.||.||| | .     ....  .  
mrlyLvRHGetewnlegrfqgw....................tdvpLtelgraqaralgell...pfdavysSpllRArqTaelil.....lpvivdprL

REQSgmHHCDQRRTRTAIHQQFPDlqlepDLPEADELWKTEREPKVALAARCTATLRTLAadpsPRVALVTHSSFLLTLFQAIL
||..  .   . .|   |....|.      |     |.  . |.  ...||. ..|. |.     .|..|.|. .. .|.. .|
rErd..fGawegltldeiaakype.....wlldlldlappggEsladvlaRvlpaleell....gnvlvvaHggvirallalll