Gene MbreHP1-Un-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP109_AA protein Get Run
MbreP109_AA_63-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051064 Phosphoglycerate mutase-like 65-316 3.7e-19 62.1 In-house 3-218 (241) alignment 
Range on Protein: 65-316
Range on HMM: 3-218/241.0
TKKLYFIRHGESTWNVTFNRDKvtfifrliyscvydayltltqsdsWfIDSPLCATGVEQADSARQYIKAKHTTSDhakflhdgraILVCSNLRRCLSTA
.|.||..|||||.||.                              | .|.|| ..|.|||  ....... .   |          ....| |.|.. ||
mkrlyLvRHGesewnaegrlqg........................w.tDvpLtelGreqaralgerladlgikfd..........avysSpllRaiqTa

IvALYDRLKRSEEKLVILPWLQEItNNPDSVSITPAFT------LPRPSWFDRNAPIMKPFDMNKSYATMLDPTENFGNKPVKGNGKQRIDAFNEVpaly
  .. ..|. .  ..|..| |.|| . ..    |.. .      . .  ..|     . .... . .  .||.. .  .. .  .|    |... |    
e.iiaealglpllpvvvdprlrEi.dfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRv....

cIRLILWLFSD-AVDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKkMKNGAIVYLQV
 .. . .|..  . | ..|....|. . .. .. .| |. ... . . ..||... | .
.lpaleellarllldgknvlvVsHggvirallayllglpleellrln.lpngsvtvlel
0048955 Phosphoglycerate mutase-like 66-316 4.6e-19 61.7 In-house 1-215 (240) alignment 
Range on Protein: 66-316
Range on HMM: 1-215/240.0
KKLYFIRHGESTWNVTFNRDKvtfifrliyscvydayltltqsdsWfIDSPLCATGVEQADSARQYIKAKHTTSDhakflhdgraILVCSNLRRCLSTAI
..||..|||||.||.                              | .|.|| ..|.|||  ....... .   |          ....| |.|.. || 
prlyLvRHGesewnaegrlqg........................w.tDvpLtelGreqaralgerLadlgikfd..........lvysSpllRaiqTae

VaLYDRLKRSEEKLVILPWLQEItNNPDSVSITPAFTL------PRPSWFDRNAPIMKPFDMNKSYATMLDPTENFGNKPVKGNGKQRIDAFNEvpalyC
  . ..|. .  ..|..| |.|. . ..    |.. .        .  ..|   . . ........ ..||..    ....  .|    |...      .
i.iaealglpllpvvvdprlrEr.dfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaR.....v

IRLILWLFSDAV-DTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKkMKNGAIVYLQV
 . . .|.. |  ....|....|. . .. .. .| |. ... . . ..||... | .
laaleellaralkpgknvlvVsHggvirallayllglpleeilrln.ipngsvtvlel
0036777 Phosphoglycerate mutase-like 65-319 1.6e-17 56.4 In-house 2-220 (247) alignment 
Range on Protein: 65-319
Range on HMM: 2-220/247.0
TKKLYFIRHGESTWNVtfnrdkvtfifrliyscvydayltLTQSDSWfIDSPLCATGVEQADSARQYIKAKHTTSDhakflhdgraILVCSNLRRCLSTA
.|.||..||||..||.                          .  .| .|.|| ..|.|||  .....|  . . |          ....| |.|.. ||
mkrlyLvRHGetewna........................egrfqgw.lDvpLtelGreqakalgellkelglpfd..........avysSpllRAiqTa

IVALyDRLKRSEEKLVILPWLQEI-------TNNPDSVSITPAFTLPRpsWFDRNAPIMKPF-------DMNKSYATMLDPTENFGNKPVKGNGKQRIDA
  .| ..|..|  ..|. | |.|.        . ..  .  |..   .  | |   ... ..        ..  . ..|. ..  |  . .   .  ..|
eiil.ealglsllpvvvdprLrErdyGalegltkaeiaekypeelvaw..wrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpa

FNEVPALYCirlilwlfsdaVDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKkKMKNGAIVYLQVSLY
..|. | .             | ..|....|. .  . .. .| |. ..  .  ...||.|. |..  .
leellarll...........kdgenvlvVsHggvlrallayllglsledilrl.nlpngsitvlelddd
0049178 Phosphoglycerate mutase-like 65-316 3.5e-17 55.3 In-house 3-216 (243) alignment 
Range on Protein: 65-316
Range on HMM: 3-216/243.0
TKKLYFIRHGESTWNVtfnrdkvtfiF----RliyscvydayltltqsdsWfIDSPLCATGVEQADSARQYIKAKHTTSDhakflhdgraILVCSNLRRC
...||..||||..||.                                  | .|||| ..|.|||  ....... . . |          ....| |.|.
mtrlyLvRHGetewna..........egrlqg..................w.tDspLtelGreqAralgellaelglkfd..........avysSplkRa

LSTAiVALYDRLKRSEEKLVILPWLQEIT-------NNPDSVSITPA---FTLPRPSWFDRNAPIMKPFDMNKSYATMLDPTENFGNKPVKGNGKQRIDA
. ||  .. ..|...  ..|..| |.|.        .  .     |      . .| ..   | ..  . ... . ...|     |  ...   .  ..|
iqTa.eiilealglpllpvvvdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpa

FNEVPALYCirlilwlfsdaVDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKkMKNGAIVYLQV
..|. | .             | .||....|. ....  . .| |. ..  . . ..||... |..
leellaell...........hdgktvlvVaHggvirallalllglpleellrln.lpngsvtvlel
0043909 Phosphoglycerate mutase-like 65-319 5.7e-16 51.2 In-house 2-224 (249) alignment 
Range on Protein: 65-319
Range on HMM: 2-224/249.0
TKKLYFIRHGESTWNVTfnrdkvtfifrliyscvydayltltQ---SdswFIDSPLCATGVEQADSARQYIKAKHTTSDhakflhdgraILVCSNLRRCL
.|.||..||||..||.                              .    .|||| ..|.|||  .....|. .   |          ....| |.|..
mkrlyLvRHGetewnae.........................grfqg...wlDspLtelGreqaralgealkelgipfd..........avysSplkRAi

STAIVALyDRLKRSEEKLVILPWLQEI-------TNNPDSVSITPAFTLPRPS-WFDRNAPIMKPFDMNKSYATMLDPTENFGNKPVKGNGKQRIDA---
 ||  .| . |...  .....| |.|.        . ..  .. |     .    .|.  | ....|  .    .   . ..    .  .|   . .   
qTaeiil.eelgldklpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvva

-----FNEVPALYCirlilwlfsdaVDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKkKMKNGAIVYLQVSLY
     ..|. | .             | ..|....|. .  . .. .| |. ... .  ...||.|. |... .
Rvlpaleellarll...........kdggnvliVaHggvlrallayllglsledilrl.nlpngsitvlelddg
0035570 Phosphoglycerate mutase-like 67-319 4.5e-15 48.2 In-house 1-178 (219) alignment 
Range on Protein: 67-319
Range on HMM: 1-178/219.0
KLYFIRHGESTWNVtfnrdkvtfifrliyscvydayltltQSDSWFiDSPLCATGVEQADSARQYIKAKHttsdhakflhDGRAILVCSNLRRCLSTAIV
.||..||||..||.                          .   .  |.|| ..|.|||  . ..... .              ....| |.|.. ||  
rlyLvRHGetewnl..........................egrlqg.dvpLterGreqaralgealadlg..........ipfdavysSpllRaiqTaei

AlydrlkrsEEKLVILPWLQEIT-------NNPDSVSITPAFTL----------Prpswfdrnapimkpfdmnksyatmldptenfgnkpvkgngkqrid
.        . ...|.| |.||        . ..  .  |              |                                             
i........glpveidprLrEidfgdlegltldeiaekypeelaawlrdpydyrp.............................................

AFNEVPALYCIRLILWLFSDaVDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKkMKNGAIVYLQVSLY
   |  | .. |.. .|     | ..|....|. .    .. .| |.  .  . . ..||... |..  .
pggEsladvvaRvlpaleel.edgenvlvVsHggvirallayllglpleeilrln.lpngsvtvleldgg
0036887 Phosphoglycerate mutase-like 65-316 3e-14 45.6 In-house 1-185 (202) alignment 
Range on Protein: 65-316
Range on HMM: 1-185/202.0
TKKLYFIRHGESTWNVtfnrdkvtfifrliY----ScvydayltltqsdsWfIDSPLCATGVEQADSARQYIKakhttsdhakflHDGRAILVCSNLRRC
...||..||||..|||                   .              . .|.|| ..|.|||  . ....            .   .....| |.|.
mtrlyLvRHGetewnv..............egrlqg..............d.ldvpLtelGreqaralgerla............glpfdavysSpllRa

LSTAIVALYDRlkrsEEKLVILPWLQEITNNPDSVSITPAFTLPRPSWFDRN---APIMKPFDMnksyatmldptenfgnkpvkgngkqridafnEVPAL
. ||  ..       . .....| |.||  .  .   .. .    | ....     . . | ..                               |  | 
iqTaeiiaeal....glpvivdprlrEidfgalegltleeiaekypeelaawlrdpydfrppgg...............................Eslad

YCIRLILWLFSD---AvDTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKKMKNGAIVYLQV
.. |.. .|      . | ..|....|. .    .. .| |.  .  . .|..||... |..
vvaRvlaaleellarl.dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel
0039931 Phosphoglycerate mutase-like 67-317 3.2e-14 45.4 In-house 1-176 (219) alignment 
Range on Protein: 67-317
Range on HMM: 1-176/219.0
KLYFIRHGESTWNVtfnrdkvtfifrliyscvydayltltQ----SdswfiDSPLCATGVEQADSARQYIKAKHTTSdhakflhdgrAILVCSNLRRCLS
.||..||||..|||                          .    .     |||| ..|.|||  . ...|  .             .....| |.|.. 
rlyLvRHGetewnv..........................egrlqg.....dspLterGreqaralgerlkdlglpf..........davysSpllRaiq

TAIVAlydrlkrsEEKLVILPWLQEITNNPDsvsiT--------------------------Paftlprpswfdrnapimkpfdmnksyatmldptenfg
||  .        . ...|.| |.||  .                                 |                                     
Taeii........glpveidprLrEidfgdl....egltleeiaekypeelaawlrdpydyrp.....................................

nkpvkgngkqridafnevP-----ALY---CIRLILWLFSdavdTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKkKMKNGAIVYLQVS
                  |     | .   ..... .|..     ..|....|. .    .. .| |.  .  .  ...||... |...
..................pggEsladvvaRvlpaleella....genvlvVsHggvirallayllglsleeilrl.nlpngsvtvleld
0037864 Phosphoglycerate mutase-like 64-316 4.3e-14 45.0 In-house 6-197 (211) alignment 
Range on Protein: 64-316
Range on HMM: 6-197/211.0
ATKKLYFIRHGESTWNVTFNRDKvtfifrliyscvydayltltqsdsWfIDSPLCATGVEQADSARQYIKAKHTTSDHakflhdgraiLVCSNLRRCLST
....||..||||..||.                              | .|.|| ..|.|||  ......  . . |.          ...| |.|.. |
lmtrlyLvRHGetewnaegrlqg........................w.ldvpLtelGreqaralgealadlglpfda..........vysSpllRaiqT

AIVALyDRLKRSEEKLVILPWLQEITNN---PDSVSITPAFTLPRPSWFDRNAPIMKPFDMnksyatmldptenfgnkpvkgngkqridafnEVPALYCI
|  .| ..|...  .....| |.|.  .     ... . ..    . .. |.     | ..                               |  | .. 
aeiil.ealglpllpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrppgg...............................Esladvva

RLILWLFSDAVDT----DTVVLCGHSLWFMSYFKEFLPLDSNHPSKKkKMKNGAIVYLQV
|.. .| . .  .    ..|....|. .  . .. .| |.  .  .  ...||... |..
RvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrl.nlpngsvtvlel
0053607 Phosphoglycerate mutase-like 66-316 3.4e-13 42.1 In-house 2-177 (191) alignment 
Range on Protein: 66-316
Range on HMM: 2-177/191.0
KKLYFIRHGESTWNVTfnrdkvtfifrliyscvydayltltQ---SdswfiDSPLCATGVEQADSARQYIKAKHTTSDHakflhdgraiLVCSNLRRCLS
..||..||||..||.                                    |.|| ..|.|||  . ..... . . |.          ...| |.|.. 
trlyLvRHGetewnae.........................grlqg.....dvpLtelGreqaralaellaelglkfda..........vysSpllRarq

TAIVAlydrlkrsEEKLVILPWLQEITNNPDSVSITPAFTL-----------------Prpswfdrnapimkpfdmnksyatmldptenfgnkpvkgngk
||  .        . .....|.|.||  .         .                   |                                         
Taeii........glpvevdprlrEidfgdwegltleelaekypeelaawlrdpldyrp.........................................

qridAFNEVPALYCIRLILWLFSDAVdTDTVVLCGHSLWFMSYFKEFLPLDSNHPSKKKkMKNGAIVYLQV
       |  | .. |.. .| . .   ..|....|. . . . . .| |. ..  . . ..||... |..
....pggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrln.lpngsvtvlel
His_Phos_1 Histidine phosphatase superfamily (branch 1) 67-189 2.6e-11 36.7 Pfam-A 1-84 (158) alignment 
Range on Protein: 67-189
Range on HMM: 1-84/158.0
KLYFIRHGESTWNvtfN--RdkvtfifrliyscvydayltltqSDSWFIDsPLCATGVEQADSARQYIKAkhttsdhakfLHDGRAILVCSNLRRCLSTA
.||..||||| ||   .  |                       ...|  . || ..| |||... ...|.           ..  .  ..|.|.|.. ||
rlylvRHGesewn...kegr.......................lqgwsdv.pLtekGreqarelgkkLkr..........adlpidavytSplkRaiqTa

IVaLYDRLKrseEKLVILPWLQEIT
 . | ..|.    .. . | |.|. 
ei.lleeld...ipiikeprLrerd
His_Phos_1 Histidine phosphatase superfamily (branch 1) 67-189 2.6e-11 36.7 In-house 1-84 (158) alignment 
Range on Protein: 67-189
Range on HMM: 1-84/158.0
KLYFIRHGESTWNvtfN--RdkvtfifrliyscvydayltltqSDSWFIDsPLCATGVEQADSARQYIKAkhttsdhakfLHDGRAILVCSNLRRCLSTA
.||..||||| ||   .  |                       ...|  . || ..| |||... ...|.           ..  .  ..|.|.|.. ||
rlylvRHGesewn...kegr.......................lqgwsdv.pLtekGreqarelgkkLkr..........adlpidavytSplkRaiqTa

IVaLYDRLKrseEKLVILPWLQEIT
 . | ..|.    .. . | |.|. 
ei.lleeld...ipiikeprLrerd
0050036 Phosphoglycerate mutase-like 113-188 1.3e-06 20.5 In-house 23-75 (171) alignment 
Range on Protein: 113-188
Range on HMM: 23-75/171.0
IDSPLCATGVEQADSARQYIkakhttsdhakflhdGRAILVCSNLRRCLSTAIVALydrlkrseEKLVILPWLQEI
.|.|| ..|..||  .....                 .....| |.|.  ||  .|         .....| |.|.
tdvpLtelgraqaralgell...............pfdavysSpllRArqTaelil........lpvivdprLrEr
subfamily_Dicty-HP1-1_pd Subfamily Dicty-HP1-1 66-91 3.8e-06 16.9 In-house 1-26 (210) alignment 
Range on Protein: 66-91
Range on HMM: 1-26/210.0
KKLYFIRHGESTWNVTFNRDKVTFIF
||.|.|||||||.|...|  .  ..|
kkvyiirhgestfnkaynekvdpylf