Gene MbreHP1-Un-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP115_AA protein Get Run
MbreP115_AA_25-182 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM_pd Subfamily PGAM 28-108 4.2e-24 77.2 In-house 2-88 (248) alignment 
Range on Protein: 28-108
Range on HMM: 2-88/248.0
TLVLLRPGSTAASGEE------DPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETN
.|||||.|..... |.      | ||...| . |...|.|.......||.||.|...|...|..|.||..|. ..||||...|.|..
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErh
0049178 Phosphoglycerate mutase-like 27-182 2.4e-18 59.1 In-house 4-226 (243) alignment 
Range on Protein: 27-182
Range on HMM: 4-226/243.0
PTLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETNTA----------
 .|.|.| | |  .      |  |. |  .| . |...|... . . .||.||.|. .| ..| . .|||... .|||... .| | .            
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkaei

---------------------------------------------------INEAAGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAVAAD
                                                   . . . |..|  ... |..| .|||||  ... .|.. .  .| . ...
aakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellr

LALEPGAAMVYTFDAATMTVQQY
| |  |.  |...|  . ... .
lnlpngsvtvlelddggwvlvsl
0037864 Phosphoglycerate mutase-like 27-180 5.5e-18 57.6 In-house 8-205 (211) alignment 
Range on Protein: 27-180
Range on HMM: 8-205/211.0
PTLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETNTA----------
 .|.|.| | |  .      |  |. |. .| . |...|.|. . . .||.||.|. .| ..| . .|||... .|||| . .| | .            
trlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltleei

-------------------INEA---------AGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFDAATMTVQ
                   . ..         . |..|  ... || | .||||.  ..| .|.. . ... . . .| |..|. .|...|  .... 
aekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddggwvlv
0043909 Phosphoglycerate mutase-like 27-177 5.7e-17 54.5 In-house 3-226 (249) alignment 
Range on Protein: 27-177
Range on HMM: 3-226/249.0
PTLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETN------------
..|.|.| | |  .      |  |. |  .| . |...|.|. . .  ||.||.|. .| ..| . .||.... .||||..  | | .            
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

-------------------------------------------------------TAINEAAGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVP
                                                        .. . . |..|  ... || | .||.||  ..| .|..   ...
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

SAVAADLALEPGAAMVYTFDAATM
 . . .| |  |.  |...|. ..
ledilrlnlpngsitvlelddggk
0036777 Phosphoglycerate mutase-like 27-177 9.8e-17 53.9 In-house 3-222 (247) alignment 
Range on Protein: 27-177
Range on HMM: 3-222/247.0
PTLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVET-------------
 .|.|.| | |  .      |  |. |  .| . |...|... . .  ||.||.|. .| ..| . .|||... .|||... .| |              
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

----------------NTAI-------------------------NEA---------AGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAVA
                ....                          ..         . |..|  ... || | .||||.  ..| .|.. . ... . .
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

ADLALEPGAAMVYTFDAATM
..| | .|.  |...|. ..
lrlnlpngsitvleldddgk
0048955 Phosphoglycerate mutase-like 27-179 3e-16 52.5 In-house 1-222 (240) alignment 
Range on Protein: 27-179
Range on HMM: 1-222/240.0
PTLVLLRPGSTAASGEE------DPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETNTAINE-------
|.|.|.| | .  . |.      |. |. .| . |...|... . . .||.||.|. .| . | . ..||..  .|||. .  | | .  . |       
prlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldei

------A--------------------------------------------------AGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAVA
      .                                                  . ...|  ... ||.| .||||.   .. .|.. .  .| . .
aekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleei

ADLALEPGAAMVYTFDAATMTV
..| . .|.  |...|   ...
lrlnipngsvtvlelddglvsl
0051064 Phosphoglycerate mutase-like 26-178 5.1e-16 51.8 In-house 3-224 (241) alignment 
Range on Protein: 26-178
Range on HMM: 3-224/241.0
TPTLVLLRPGSTAASGEE------DPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLFLPVEKEANLVETNTAIN-------
...|.|.| | .  . |       |. |. .| . |...|... . . .||.||.|. .| . | . ..||..  .|||. .  | | .  .        
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

------EA--------------------------------------------------AGPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAV
      |.                                                  . |..|  ... |..| .||||.   .. .|.. .  .| . 
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

AADLALEPGAAMVYTFDAATMT
. .| | .|.  |...|. . .
llrlnlpngsvtvleldddgkr
0036887 Phosphoglycerate mutase-like 27-182 4.1e-15 48.4 In-house 2-195 (202) alignment 
Range on Protein: 27-182
Range on HMM: 2-195/202.0
PTLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMVheHADFDVVYCSTRRRDVKTTNVVLEAIDrlfLPVEKEANLVETNTAINEA------
 .|.|.| | |  .      |  |. |. .| . |...|...   . .||.||.|. .| ..| . ..||..   |||. .  | | .  . |       
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleei

--------------------------------AGPVWELDIRPKlkAGLRVLVVAELPTLACLVSKVDSVPSAVAADLA-LEPGAAMVYTFDAATMTVQQ
                                . ...|  ...   .| .||||.  ..| .|.. .  .. . . .|  | .|. .|...|. ....  
aekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl

Y
.
l
0039931 Phosphoglycerate mutase-like 28-182 1.4e-14 46.5 In-house 1-185 (219) alignment 
Range on Protein: 28-182
Range on HMM: 1-185/219.0
TLVLLRPGSTAAS------GeeDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVleaidrlFLPVEKEANLVETNTAI---------N
.|.|.| | | ..      |  |. |  .| . |...|... . . .||.||.|. .| ..| . .        |||| .  | | .  .          
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

EA-----------------------------AGPVWELDIRpklkaGLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFDAATMTVQQY
|                              . |..|  ..     | .||||.  ... .|.. .  .. . ...| | .|.  |...|. ....  .
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella.....genvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvll
subfamily_PGAM_pd Subfamily PGAM 116-180 2.9e-14 45.0 In-house 161-225 (248) alignment 
Range on Protein: 116-180
Range on HMM: 161-225/248.0
GPVWELDIRPKLKAGLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFDAATMTVQ
 ||.. .|....|.| |||.||. .....|..............|.|..| ..||..|    .|.
lpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaikeldlptgiplvyeldenlkpvk
0035570 Phosphoglycerate mutase-like 28-179 3.2e-14 45.4 In-house 1-182 (219) alignment 
Range on Protein: 28-179
Range on HMM: 1-182/219.0
TLVLLRPGSTAA------SGeeDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVleaidrlFLPVEKEANLVETNTAINEA-------
.|.|.| | |         |  |. |  .| . |...|.|. . . .||.||.|. .| ..| . .        |||| .  | | .  . |        
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia

-------------------------------AGPVWELDirpklKAGLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFDAATMTV
                               . |..|       . | .||||.  ... .|.. .  .| . ...| | .|.  |...|. ....
ekypeelaawlrdpydyrppggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkw
0053607 Phosphoglycerate mutase-like 28-182 8.9e-14 44.0 In-house 3-187 (191) alignment 
Range on Protein: 28-182
Range on HMM: 3-187/191.0
TLVLLRPGSTAA------SGeeDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVleaidrlFLPVEKEANLVETNTAINEA-------
.|.|.| | | .       |  |. |. .| . |....... . . .||.||.|. .| ..| . .        |||| . .| | .  . |        
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela

-------------------------------AGPVWELDIRpklkaGLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFDAATMTVQQY
                               . |..|  ..     | .|||||  ... .|.. . ..| . .  | |..|. .|...|  ....  .
ekypeelaawlrdpldyrppggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvll
His_Phos_1 Histidine phosphatase superfamily (branch 1) 28-109 1.9e-11 37.1 Pfam-A 1-85 (158) alignment 
Range on Protein: 28-109
Range on HMM: 1-85/158.0
TLVLLRPGSTA------ASGEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDrlfLPVEKEANLVETNT
.|.|.| | .       ..|..|..|  .| . |...|... ...  .|.||.|. .| ..|....|| .|   .|..|| .| | . 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdf
His_Phos_1 Histidine phosphatase superfamily (branch 1) 28-109 1.9e-11 37.1 In-house 1-85 (158) alignment 
Range on Protein: 28-109
Range on HMM: 1-85/158.0
TLVLLRPGSTA------ASGEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDrlfLPVEKEANLVETNT
.|.|.| | .       ..|..|..|  .| . |...|... ...  .|.||.|. .| ..|....|| .|   .|..|| .| | . 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdf
0050036 Phosphoglycerate mutase-like 28-173 7.4e-11 34.2 In-house 2-168 (171) alignment 
Range on Protein: 28-173
Range on HMM: 2-168/171.0
TLVLLRPGSTAAS------GEEDPKLDSTGLALAERVGHAMvhehaDFDVVYCSTRRRDVKTTNVVLeaidrlfLPVEKEANLVETNTAINEA-------
.|.|.| | | ..      |  |. |. .|.| |...|...     .||.||.|. .| ..| . .|       |||... .| | .  . |        
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia

---------------------------AGPVWELDIrpklkagLRVLVVAELPTLACLVSKVDSVPSAVAADLALEPGAAMVYTFD
                           . |..|  .        .|||||   .. .|.. .  .. . . .| |..|. .|...|
akypewlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglsleeilrlelpngsvlvleld
subfamily_STS_pd Subfamily STS 40-110 7e-09 27.4 In-house 48-117 (245) alignment 
Range on Protein: 40-110
Range on HMM: 48-117/245.0
SGEEDPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDrLFLPVEKEANLVETNTA
. ..|| | ..|   |. .|.|......  ....||   | . |.. .|....   .... |  |.|    
dyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkl
subfamily_PGAM5_pd Subfamily PGAM5 28-108 5.5e-06 17.6 In-house 3-82 (189) alignment 
Range on Protein: 28-108
Range on HMM: 3-82/189.0
TLVLLRPGSTAASGEE-DPKLDSTGLALAERVGHAMVHEHADFDVVYCSTRRRDVKTTNVVLEAIDRLflPVEKEANLVETN
 |.|.| |    ...  .  | . |   ||..|. . . . .|. .. ||  | | |...... ..    |.. ...|..  
hlilvrhgqyvldddsdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdv..pkktktellreG