Gene MbrePPM-Un-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP121_AA protein Get Run
MbreP121_AA_1106-1430 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 1105-1430 4.1e-160 524.1 In-house 6-315 (317) alignment
Range on Protein: 1105-1430
Range on HMM: 6-315/317.0
NASVNQDSYFLTSGRLAGvGRFSLAAVFDGHSPGGERASQCAADTLNKIvgaavrreadrLPELVanhrlelWEHVAHEPDTLLKAIFKRLHTAIIDDYA
.. .|||.|||.|..||| .|..|||||||||..||.|...|.|||...           |||||       |.....||..|||.||.||..||...|.
hgklnqdvyflasfklaG.hrialaavfdGhsllGeiaaamardtltal...........lPelv.......wdslltePeqllkeifarldaaivaayd

QWPAEYEYT-QGGQL------HRFARLDHPKWGQCIVRHDGHTSPLDYGTTAAIALLLhlsdDRMMFACAHAGD--SLVALARCNQPLKADGLDLGYVTR
..||||||. |.|.|      |..|.||.||...||.|.|..|.|||.||||..|...    |......|.|||  .||.|.........|||.......
apPaeyeyigqsGsldfrleahaiaeldpPkgyvcisrddvptrPldfGttavvavvv....dethvvvanaGdaaalvllrdqaghedrdGlsvealsv

RHNLHSADERERVASVLGQRGHVTEDHYLAIDDEAdLRAHQVQISKSLGHKQLSAYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLART
||.|.|..||.|||.||....|||||.||||.||| |.|...|..||||||.|...||...|....||||.||.||..||||||||.|||...||...|.
rhtlrskaerarvaevlpgaahvtedgylaildea.laayelqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlra

ATAQEAAQQLCDDAHaNNMLAVNSSDDCTAVLLCL
|||.||...|||||. ...|...|.||.|||.|.|
ataleasevlcddaq.dylldetsiddatavvlll

0034914 PP2C-like 1107-1430 9.5e-30 96.6 In-house 33-290 (295) alignment
Range on Protein: 1107-1430
Range on HMM: 33-290/295.0
SVNQDSYFLTSGRLAGVGRFSLAAVFDGHSpgGERASQCAADTLNKIVGAAVRREadrlpelvanhrLELWEHVAHEPDTLLKAIFKRLHTAIIDDYAQW
. |.|...   . | . . ..|..|||||.  | .|.. |...| ...  ....             | |...  . . . |. .|.... ....   ..
ksneDavlvvlnllslledlllfgvfDGhg..Ghaaaevasellvelllellekl............lllltlsledieealrkaflaadeellelallr

paeyeytqggqlhrfarldhpkwgqcivrhdghTSPLDYGTTAAIALLlhlSDDrmMFACAHAGDSLVALARCNqplkadglDLGYVTRRHNLHSADERE
                                  . . .|||| .||.    ..  .. .|..||| . | | .         | ..|. |.. . .|||
.................................pelagsGtTavvali...rgn..klyvanvGDSravllrng........elvqltvdhkpvnelere

RVASVLGQRGHvtedhylaiddeaDLRAHQVQISKSLGHKQLS--------AYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLAR----
|. |  |   |             . .  . .....||. .|          ..|| |||..|. |. ..   .|. |||..| |  . |.|....    
rilsaggavsh.............grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllak

TATAQEAAQQLCDDAHAnnmlaVNSSDDCTAVLLCL
. ...|||..|.| | |      .|.|..|.|...|
gldleeaaeeLvdlAla.....rgsrDNiTvvvvrl

0049733 PP2C-like 1107-1429 1.2e-20 67.1 In-house 16-232 (235) alignment
Range on Protein: 1107-1429
Range on HMM: 16-232/235.0
SVNQDSYFLtsgrlagvgRFSLAAVFDGHSpgGERASQCAADTLNKIVGAAVRReadrlpelvanhrlelweHVAHEPDTLLKAIFKRLHTAIIDDyaqw
.||.|....          ..|.||.|||.  | .|.. |...| ... .....                  .  ... ..|...|.....|...     
kvneDavlv.........glllfavaDGhg..ghaagevasellvetllellle..................lllldleealrkaflaaneallel....

paeyeytqggqlhrfarldhpkwgqcivrHDGHTSPLDYGTTAAIALLLhlsDDrmMFACAHAGDSLVALARCNQplkadgldLGYVTRRHNLHSADERE
                                . .   .||||..|||    ..  .. .|..||| . | | ..        | ..|. |..   .||.
.............................alaspelagmgtTavvalld...gg..klyvanvGDsrayllrdgk........lvqltedhspvnelerq

RVASVLGQRghvtedhylaiddeadLRAHQVQISKSLGHKQLSaygvsfePDCYVRVLDADEtfAILVVSDGITDGLKRDVILDVLARtATAQEAAQQLC
|. .  | .                   .. .....||. .|.       || .|  |....   .|. |||..| |  . |.|.|..  ...|||..|.
riitaggav................rvpgrlaltralGdlllk.......pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs.ldleeaaerlv

DDAHAnnmlaVNSSDDCTAVLLC
. |.|      .. |..|.|...
elala.....rggrDNiTvvvvr

Myb_DNA-binding Myb-like DNA-binding domain 813-855 5.2e-14 38.6 Pfam-A 2-46 (48) alignment
Range on Protein: 813-855
Range on HMM: 2-46/48.0
GPFVPSEDRILLQAQMQHGND-WIEVAKMLP-GRTDEAIRLRWQE
|.. . || .|..|  |.|.. |  .|.... |||.. ...||| 
grWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk

Myb_DNA-bind_6 Myb-like DNA-binding domain 817-859 1e-12 34.6 Pfam-A 3-46 (60) alignment
Range on Protein: 817-859
Range on HMM: 3-46/60.0
PSEDRILLQAQMQHGNDWIEVAKMLpG-RTDEAIRLRWQE-LSSV
. ||.|||.  ...|||| |.|..| | || .|.. ||.. |...
deEdeiLlklveeygndWseIaeel.grRtplacqdrwknkLrpk

subfamily_PPM1K_pd Subfamily PPM1K 1239-1427 4.6e-10 32.1 In-house 92-255 (263) alignment
Range on Protein: 1239-1427
Range on HMM: 92-255/263.0
HTSPLDYGTTAAIALLLhlsdDRMMFACAHAGDSLVALARCNQPLKadgldlgyVTRRHNLHSADERERVASVLGQRGHVTEDHYlaiddeadLRAHQVQ
... |  ||||...||     | . .. |  |||   | |  .. |        .|| |. .  .|.||. .. |.    . ..         |   .. 
eaellssGttatvsllr....dGtelvlaslGdsrailcrnGkakk........ltrdhdPeleeekerikaagGsvewnslgkp........lvngrla

ISKSLGHKQLSAYGVSFEPDCY-VRVLDADETFAILvVSDGITDGLKRDVILDVLARTATAQEAAQQLCDDAhannmLAVNSSDDCTAVL
...|||  .|  |||  .|.   ..|  |...| .| ..|||.. ..   . |..      .|||. |.. |     |   | |..|||.
mtrslGdldlkryGviatPetkslkvdhaadsflvl.itdgisfvvnsqelcdlvrlchdpeeaahalteqa.....lqygsednatavv

Recep_L_domain Receptor L domain 334-398 3.9e-07 16.6 Pfam-A 3-66 (112) alignment
Range on Protein: 334-398
Range on HMM: 3-66/112.0
TNITGSLRLYNCGDSLTAADLHIFNNLARVDGSVIIYNNdALTNIDALGRLASVGDRIQIYHNNL
| |.|.|..    .. . .||. ..|.  . |...|... .|.... | .|  .  | .. .|. 
tvieGnLeitleeeneeeedlsflknieeitGyllikrt.nlkslsflknLrvIrgrelfednya

subfamily_PPM1D_pd Subfamily PPM1D 1127-1402 2e-06 20.1 In-house 36-271 (309) alignment
Range on Protein: 1127-1402
Range on HMM: 36-271/309.0
SLAAVFDGHspGGERASQCAADTLNKIVGAAVRREADRlPELVanhrlelwehvahepdtllkaifkrlhtaiiddyaqwpaeYEYTQGG--QLHRFARL
.  ||||||  ||. |.. | . | . .       ..  || |                                         |  . .  ..|.  . 
afvavfDGH..GGkeAakfarehlwsvikkqkkflsse.pedv........................................leAireaflatheamkk

DHPKWGQcivRHDGHTSplDYGTTAAIALLLhlsdDRMMFaCAHAGDSLVALARCNQplKADGLDLGYVTRRHNLHSADERERVASVLGQRGHV------
 . .| .   ...|. |    ||||.. ..     .. ..  || ||| . |.  ..  | . |    .|. |  .| .|.||.... |.  .       
kleeWpk...tksglls..taGttasvviir....rekly.vahvGDsaivlgvkep..kekklrakeltkdHkPespeekerieelGGevaaksGvkRv

-TEDHYLAIDDE-ADLRAHQVQISKSLG-----HKQLSAYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLARTATAQEAA
  . . |  ...    .   .....|||      ..  .. || ||| .||.|| .|.  |.. |||... |. .   .|. .. . .|  
vWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelk

subfamily_PPM1E_pd Subfamily PPM1E 1245-1427 2e-06 20.2 In-house 102-259 (265) alignment
Range on Protein: 1245-1427
Range on HMM: 102-259/265.0
YGTTAAIALLlhlSDDRmmFACAHAGDSLVALARCNQPLKadgldlgyVTRRHNLHSADERERVASVLGQRGHVtedHYLAIDdeadlraHQVQISKSLG
 |.|| ..|.   . |.  .. |  ||| ..| |  . ..        ... |.    ||..|...  |.  ..     . ..        ....|...|
sGstavvvli...ekdq..lyvaWlGDsqallvrkgeavq........lmkpHkPeredEkkRieeagGlvvvi...gawRvn.......GvLsvsRaiG

HKQLSAYgVSFEPDCYVRVLDADETFaILVVSDGITDGLKRDVILDVLA----RTA-TAQEAAQQLCDDAHANnmlavNSSDDCTAVL
 ..| .| || |.|.    || .| . ... .||. | .... .....     ..| . .|.|..|.. |. .     .|||. |.|.
Dvklkpy.vsgeadvaeveldgseey.lilacDGlwDvvneeevvklveefladgaedlsevakllveaakea.....gssDnitvvv