Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Choan-PPM-1_pd | Subfamily Choan-PPM-1 | 1105-1430 | 4.1e-160 | 524.1 | In-house | 6-315 (317) | alignment | ||
Range on Protein: 1105-1430
Range on HMM: 6-315/317.0
NASVNQDSYFLTSGRLAGvGRFSLAAVFDGHSPGGERASQCAADTLNKIvgaavrreadrLPELVanhrlelWEHVAHEPDTLLKAIFKRLHTAIIDDYA
.. .|||.|||.|..||| .|..|||||||||..||.|...|.|||... ||||| |.....||..|||.||.||..||...|.
hgklnqdvyflasfklaG.hrialaavfdGhsllGeiaaamardtltal...........lPelv.......wdslltePeqllkeifarldaaivaayd
QWPAEYEYT-QGGQL------HRFARLDHPKWGQCIVRHDGHTSPLDYGTTAAIALLLhlsdDRMMFACAHAGD--SLVALARCNQPLKADGLDLGYVTR
..||||||. |.|.| |..|.||.||...||.|.|..|.|||.||||..|... |......|.||| .||.|.........|||.......
apPaeyeyigqsGsldfrleahaiaeldpPkgyvcisrddvptrPldfGttavvavvv....dethvvvanaGdaaalvllrdqaghedrdGlsvealsv
RHNLHSADERERVASVLGQRGHVTEDHYLAIDDEAdLRAHQVQISKSLGHKQLSAYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLART
||.|.|..||.|||.||....|||||.||||.||| |.|...|..||||||.|...||...|....||||.||.||..||||||||.|||...||...|.
rhtlrskaerarvaevlpgaahvtedgylaildea.laayelqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlra
ATAQEAAQQLCDDAHaNNMLAVNSSDDCTAVLLCL
|||.||...|||||. ...|...|.||.|||.|.|
ataleasevlcddaq.dylldetsiddatavvlll
|
|||||||||
0034914 | PP2C-like | 1107-1430 | 9.5e-30 | 96.6 | In-house | 33-290 (295) | alignment | ||
Range on Protein: 1107-1430
Range on HMM: 33-290/295.0
SVNQDSYFLTSGRLAGVGRFSLAAVFDGHSpgGERASQCAADTLNKIVGAAVRREadrlpelvanhrLELWEHVAHEPDTLLKAIFKRLHTAIIDDYAQW
. |.|... . | . . ..|..|||||. | .|.. |...| ... .... | |... . . . |. .|.... .... ..
ksneDavlvvlnllslledlllfgvfDGhg..Ghaaaevasellvelllellekl............lllltlsledieealrkaflaadeellelallr
paeyeytqggqlhrfarldhpkwgqcivrhdghTSPLDYGTTAAIALLlhlSDDrmMFACAHAGDSLVALARCNqplkadglDLGYVTRRHNLHSADERE
. . .|||| .||. .. .. .|..||| . | | . | ..|. |.. . .|||
.................................pelagsGtTavvali...rgn..klyvanvGDSravllrng........elvqltvdhkpvnelere
RVASVLGQRGHvtedhylaiddeaDLRAHQVQISKSLGHKQLS--------AYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLAR----
|. | | | . . . .....||. .| ..|| |||..|. |. .. .|. |||..| | . |.|....
rilsaggavsh.............grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllak
TATAQEAAQQLCDDAHAnnmlaVNSSDDCTAVLLCL
. ...|||..|.| | | .|.|..|.|...|
gldleeaaeeLvdlAla.....rgsrDNiTvvvvrl
|
|||||||||
0049733 | PP2C-like | 1107-1429 | 1.2e-20 | 67.1 | In-house | 16-232 (235) | alignment | ||
Range on Protein: 1107-1429
Range on HMM: 16-232/235.0
SVNQDSYFLtsgrlagvgRFSLAAVFDGHSpgGERASQCAADTLNKIVGAAVRReadrlpelvanhrlelweHVAHEPDTLLKAIFKRLHTAIIDDyaqw
.||.|.... ..|.||.|||. | .|.. |...| ... ..... . ... ..|...|.....|...
kvneDavlv.........glllfavaDGhg..ghaagevasellvetllellle..................lllldleealrkaflaaneallel....
paeyeytqggqlhrfarldhpkwgqcivrHDGHTSPLDYGTTAAIALLLhlsDDrmMFACAHAGDSLVALARCNQplkadgldLGYVTRRHNLHSADERE
. . .||||..||| .. .. .|..||| . | | .. | ..|. |.. .||.
.............................alaspelagmgtTavvalld...gg..klyvanvGDsrayllrdgk........lvqltedhspvnelerq
RVASVLGQRghvtedhylaiddeadLRAHQVQISKSLGHKQLSaygvsfePDCYVRVLDADEtfAILVVSDGITDGLKRDVILDVLARtATAQEAAQQLC
|. . | . .. .....||. .|. || .| |.... .|. |||..| | . |.|.|.. ...|||..|.
riitaggav................rvpgrlaltralGdlllk.......pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs.ldleeaaerlv
DDAHAnnmlaVNSSDDCTAVLLC
. |.| .. |..|.|...
elala.....rggrDNiTvvvvr
|
|||||||||
Myb_DNA-binding | Myb-like DNA-binding domain | 813-855 | 5.2e-14 | 38.6 | Pfam-A | 2-46 (48) | alignment | ||
Range on Protein: 813-855
Range on HMM: 2-46/48.0
GPFVPSEDRILLQAQMQHGND-WIEVAKMLP-GRTDEAIRLRWQE
|.. . || .|..| |.|.. | .|.... |||.. ...|||
grWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk
|
|||||||||
Myb_DNA-bind_6 | Myb-like DNA-binding domain | 817-859 | 1e-12 | 34.6 | Pfam-A | 3-46 (60) | alignment | ||
Range on Protein: 817-859
Range on HMM: 3-46/60.0
PSEDRILLQAQMQHGNDWIEVAKMLpG-RTDEAIRLRWQE-LSSV
. ||.|||. ...|||| |.|..| | || .|.. ||.. |...
deEdeiLlklveeygndWseIaeel.grRtplacqdrwknkLrpk
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 1239-1427 | 4.6e-10 | 32.1 | In-house | 92-255 (263) | alignment | ||
Range on Protein: 1239-1427
Range on HMM: 92-255/263.0
HTSPLDYGTTAAIALLLhlsdDRMMFACAHAGDSLVALARCNQPLKadgldlgyVTRRHNLHSADERERVASVLGQRGHVTEDHYlaiddeadLRAHQVQ
... | ||||...|| | . .. | ||| | | .. | .|| |. . .|.||. .. |. . .. | ..
eaellssGttatvsllr....dGtelvlaslGdsrailcrnGkakk........ltrdhdPeleeekerikaagGsvewnslgkp........lvngrla
ISKSLGHKQLSAYGVSFEPDCY-VRVLDADETFAILvVSDGITDGLKRDVILDVLARTATAQEAAQQLCDDAhannmLAVNSSDDCTAVL
...||| .| ||| .|. ..| |...| .| ..|||.. .. . |.. .|||. |.. | | | |..|||.
mtrslGdldlkryGviatPetkslkvdhaadsflvl.itdgisfvvnsqelcdlvrlchdpeeaahalteqa.....lqygsednatavv
|
|||||||||
Recep_L_domain | Receptor L domain | 334-398 | 3.9e-07 | 16.6 | Pfam-A | 3-66 (112) | alignment | ||
Range on Protein: 334-398
Range on HMM: 3-66/112.0
TNITGSLRLYNCGDSLTAADLHIFNNLARVDGSVIIYNNdALTNIDALGRLASVGDRIQIYHNNL
| |.|.|.. .. . .||. ..|. . |...|... .|.... | .| . | .. .|.
tvieGnLeitleeeneeeedlsflknieeitGyllikrt.nlkslsflknLrvIrgrelfednya
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 1127-1402 | 2e-06 | 20.1 | In-house | 36-271 (309) | alignment | ||
Range on Protein: 1127-1402
Range on HMM: 36-271/309.0
SLAAVFDGHspGGERASQCAADTLNKIVGAAVRREADRlPELVanhrlelwehvahepdtllkaifkrlhtaiiddyaqwpaeYEYTQGG--QLHRFARL
. |||||| ||. |.. | . | . . .. || | | . . ..|. .
afvavfDGH..GGkeAakfarehlwsvikkqkkflsse.pedv........................................leAireaflatheamkk
DHPKWGQcivRHDGHTSplDYGTTAAIALLLhlsdDRMMFaCAHAGDSLVALARCNQplKADGLDLGYVTRRHNLHSADERERVASVLGQRGHV------
. .| . ...|. | ||||.. .. .. .. || ||| . |. .. | . | .|. | .| .|.||.... |. .
kleeWpk...tksglls..taGttasvviir....rekly.vahvGDsaivlgvkep..kekklrakeltkdHkPespeekerieelGGevaaksGvkRv
-TEDHYLAIDDE-ADLRAHQVQISKSLG-----HKQLSAYGVSFEPDCYVRVLDADETFAILVVSDGITDGLKRDVILDVLARTATAQEAA
. . | ... . .....||| .. .. || ||| .||.|| .|. |.. |||... |. . .|. .. . .|
vWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelk
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 1245-1427 | 2e-06 | 20.2 | In-house | 102-259 (265) | alignment | ||
Range on Protein: 1245-1427
Range on HMM: 102-259/265.0
YGTTAAIALLlhlSDDRmmFACAHAGDSLVALARCNQPLKadgldlgyVTRRHNLHSADERERVASVLGQRGHVtedHYLAIDdeadlraHQVQISKSLG
|.|| ..|. . |. .. | ||| ..| | . .. ... |. ||..|... |. .. . .. ....|...|
sGstavvvli...ekdq..lyvaWlGDsqallvrkgeavq........lmkpHkPeredEkkRieeagGlvvvi...gawRvn.......GvLsvsRaiG
HKQLSAYgVSFEPDCYVRVLDADETFaILVVSDGITDGLKRDVILDVLA----RTA-TAQEAAQQLCDDAHANnmlavNSSDDCTAVL
..| .| || |.|. || .| . ... .||. | .... ..... ..| . .|.|..|.. |. . .|||. |.|.
Dvklkpy.vsgeadvaeveldgseey.lilacDGlwDvvneeevvklveefladgaedlsevakllveaakea.....gssDnitvvv
|