Gene PDP in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PDPc
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP124_AA protein Get Run
MbreP124_AA_134-445 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PDP_pd Subfamily PDP 192-393 4.5e-77 252.8 In-house 111-316 (398) alignment 
Range on Protein: 192-393
Range on HMM: 111-316/398.0
DELTICEALEQAFLDFDRDF-TETVPNMalktgNSDVIEAFVNPALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGVGHRPVI-MSIDQTGDTPSEIL
.  ...|||..|||..|.|. ||.....     .. ... ....||.||....|||..| ..||||||||.|.||... |.. .. .|.|||.|...|. 
evekvkealkkaFlklDkdistealkkl.....kekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEve

RLQQEHPGEEE-SVVRRGRVLGNLQPARAFGDSRYKWSRDlMQQ-------LGVRVPNGYLTPPYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAA
|...||||||. .|.|.||.||.|||.||||| |||||.. .|.       |.|. |. | ||||.||.|||. ....... ||..|||||||....|..
RikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwsee.lqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneev

VQTVSQALANGA
|..|.. ||. .
vslVgehlakkk
PP2Cc_SM00332 135-441 8.9e-53 172.4 In-house 18-274 (274) alignment 
Range on Protein: 135-441
Range on HMM: 18-274/274.0
LNANDPMEDRHSAHSL---GAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNAdELTICEALEQAFLDFDRDFTETVPNMALKTgnsdvieaf
 .....|||.|  .      . . ..| ||||.| .... .|  | ......| ..  .  |  . |||..|||..| ...|   .. |.          
qgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqskelen.........

vnpALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGvghrPVIMSIDQTGDTPSEILRLQQEHPgeeesVVRRGRVLGNLQPARAFGDSRYKWSRdlmq
   ||.|.  | ||..   ..|||.||.|.|..  .      | .| |.... ..|. |......     ||..||| |.|.  |||||  .|...    
...alsGstavvallkkedlyvanvGDSravlcrngk....avqlsvdhkpedederkRikkagg.....vvekgrvngglavsrafGdhflkknk....

qlgvrvpngYLTPPYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGA--DALSAAGKLVHHALENyareaqlpldslmeipagqa
         .|..||.|| |.|      ... |||.|.||||||.... .|..| . ||.|.  |.  || .|. .|...                    
.........klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....................

RNFRDDITVTVV
.. .|.||| ||
ggseDniTvvvv
0034914 PP2C-like 135-445 9.3e-53 171.9 In-house 29-292 (295) alignment 
Range on Protein: 135-445
Range on HMM: 29-292/295.0
LNANDPMEDRHSAHS----LGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNV--PPNADELTICEALEQAFLDFDRDFTETVPNMalktgnsdvi
 . ....||.....     |  ...|.|.||||.| ||.. ||  | ... . | ..      .. .|.|||..|||  |... |.. ..          
qGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr..........

eafVNPALAGAVSVNALIHPTGIFVANTGDCRCVMGvRRGvghRPVIMSIDQTGDTPSEILRLQQEHPgeeesVVRRGRVLGNLQPARAFGDSRYKWSrd
    . |  |.  | |||... ..|||.||.|.|.  |.|   ..| ...|.. . ..|. |......     .|. |||.|.|.  ||.|| ..|..  
...pelagsGtTavvalirgnklyvanvGDSravll.rng...elvqltvdhkpvnelererilsagg.....avshgrvngvlavtRalGdfdlkll..

lmqqlgvrvPNGYLTPPYVTARPEVLFYPHA-PANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALEnyareaqlpldslmeipag
         .. .|..|.|.| |.| ...   . . ||..|.||||||...| .|. |.. ||.| |.  || .||..||.                   
.........lslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla...................

qaRNFRDDITVTVVMLDS
  |. ||.||| || |..
..rgsrDNiTvvvvrlng
PP2C Protein phosphatase 2C 138-410 3.5e-37 121.4 Pfam-A 12-250 (255) alignment 
Range on Protein: 138-410
Range on HMM: 12-250/255.0
NDPMEDRHSAHS------LGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNadelTICEALEQAFLD-FDRDFTEtvpnmalktgN--Sdvi
 ..|||.| |           .  ... |||| |  |.. |.. |   .... .  . .      ..|| ..||  .|  ..           .  .   
rksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks..........skan...

eaFvNPALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGVGhrpVIMSIDQTGDTPSEILRLQQEHPGEEEsvvrRGRVLGNLQPARAFGDSRYKWSRd
     |   |...| ||| .. ..|||.||.|.|.. ...     . .. |.. . ..|. |.....   ..     ||| |.|. .||.|| ..|    
..t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak...keltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpke.

lmqqlgvrvpngyltPPYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALENY
               ...|.| |.|   .  . . |||.|.||||||.... ||. | . |  . ..  || .|| .|... 
...............eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiarg
PP2C Protein phosphatase 2C 138-410 3.5e-37 121.4 In-house 12-250 (255) alignment 
Range on Protein: 138-410
Range on HMM: 12-250/255.0
NDPMEDRHSAHS------LGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNadelTICEALEQAFLD-FDRDFTEtvpnmalktgN--Sdvi
 ..|||.| |           .  ... |||| |  |.. |.. |   .... .  . .      ..|| ..||  .|  ..           .  .   
rksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks..........skan...

eaFvNPALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGVGhrpVIMSIDQTGDTPSEILRLQQEHPGEEEsvvrRGRVLGNLQPARAFGDSRYKWSRd
     |   |...| ||| .. ..|||.||.|.|.. ...     . .. |.. . ..|. |.....   ..     ||| |.|. .||.|| ..|    
..t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak...keltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpke.

lmqqlgvrvpngyltPPYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALENY
               ...|.| |.|   .  . . |||.|.||||||.... ||. | . |  . ..  || .|| .|... 
...............eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiarg
PPM_PTC7 139-409 1.9e-35 115.6 In-house 13-253 (259) alignment 
Range on Protein: 139-409
Range on HMM: 13-253/259.0
DPMEDRHSAHS------LGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNadelTICEALEQAFLD--FDRDFTEtvpnmalktgnS--Dvi
..|||.| |           .  ... |||| |  |.. |.. |   .... .  . .      ..||  .||   .|  ..            |     
ksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelks...........sean..

eafVNPALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGVGhrpVIMSIDQTGDTPSEILRLQQEHPGEEESvvRRGRVLGNLQPARAFGDSRYKWS-R
     |   |.. | ||| .. ..|||.||.|.|.. ....    . .. |.. . ..|. |.....   ..   ..||| |.|. .||||| ..|   .
...tepstsGstAvvalitgsklyvAnvGDSravLcrsgnav...kqltedHkpsnedEreRiegaggsvsnv..gngrvngvlavsRafGdfelkpket

dlmqqlgvrvpngylTPPYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGaDALSAAGKLVHHALEN
               ....|.| |..   .  . . |||.|.|||||||... ||. | . |. . |.  || ||| .|...
...............eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiar
0049733 PP2C-like 138-444 6.1e-35 113.7 In-house 15-234 (235) alignment 
Range on Protein: 138-444
Range on HMM: 15-234/235.0
NDPMEDRHSAhslgaHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNvppnADELTICEALEQAFLDFDRDFTETvpnmalktgnsdvIEAFVNPALA
.. .||.. .     ...|....|||.| ||.. ||  | ... . | .     ..|...|||..|||  .. . |.              .|  . |  
rkvneDavlv.....glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallel.............alaspelagm

GAVSVNALIHPTGIFVANTGDCRCVMGvRrgvGHRPVIMSIDQTGDTPSEILRLQQEHPGEeesvvrrgRVLGNLQPARAFGDSRYKwsrdlmqqlgvrv
|.  | ||...  ..||| ||.|...  |   . . | .. |..   . |  |......          ||.| |.  ||.||. .|             
gtTavvalldggklyvanvGDsrayll.r...dgklvqltedhspvnelerqriitaggav........rvpgrlaltralGdlllk.............

pngyltppyvtarPEVLFYPHAPANaFLIMATDGLWDVVDPEAAVQTVSQalangADALSAAGKLVHHALEnyareaqlpldslmeipagqaRNFRDDIT
             |.| ...  | . ||..|.||||||...| .|.....      |.  || .||..||.                     |. ||.||
.............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala.....................rggrDNiT

VTVVMLD
| ||.||
vvvvrld
subfamily_PPM1A_pd Subfamily PPM1A 135-411 3.1e-33 108.3 In-house 20-269 (282) alignment 
Range on Protein: 135-411
Range on HMM: 20-269/282.0
LNANDPMEDRHSA-HSLGAH--GVLVGMFDGHSGFAASDAASTFLSSYINK--SLTN-VPPNADELTICEALEQAFLDFDRDFTETVPNMALKtGNSdvi
 .    |||.|..  ||||   . .  .||||.|  ... ... | . | .  .|..    . .. .. |||.|.||..| .  |.  ..  .  .|   
qgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlkta.dks...

eafvnpalaGAVSVNALIHPTGIFVANTGDCRCVMgVRRGvghRPVIMSIDQTGDTPSEILRLQQEHpGeeesVVRRGRVLGNLQPARAFGDSRYKWSRD
         |. .| .|.... ...|| ||.| |. .| |   . .... |  ...|.|  |..|   |     |  .|| |.|  .||.||  || . .
.........GsTavtvlvsekhliianlGDsRavl.crng...kaaflteDHkpsrpkEkkRieqAG.G....svvvsRvnGaLAvsRalGDyeykeeee

LMQQLGvrvpngyltppYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALENYA
. ..              |.| |||        . ||..| ||.|||.. | .|. | . |  . .. . | .||..|||. .
kkaeeq...........lvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgs
subfamily_PPM1G2_pd Subfamily PPM1G2 152-420 1.5e-28 92.6 In-house 50-278 (287) alignment 
Range on Protein: 152-420
Range on HMM: 50-278/287.0
AHGVLVGMFDGHSGFAASDAASTFLSSYINKsltnvPPNADELTICEALEQAFLDFDRDFTETvpnmalktgnsdviEAFVNpALAGAVSVNALIHPTGI
 . .|...|||| | ...  |.. | ..|.|      .. .| .. ..|..|||..|.....               |.. .   ||. .| .||. . .
kslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkd..............eklkd.esaGstavvvlikeekl

FVANTGDCRCVMGVRrgvGHrPVIMSIDQTGDTPSEILRLQQEhpgeeESVVRRGRVLGNLQPARAFGDSRYKWSRDlmqqlgvrvpngylTP---PYVT
.|||.|| |.|. ..   |.    .|.|   .. ||  |...      . .|  .|| |||  .||.||  .| .                ..     ||
yvanaGDsravlssk...gn.vkalsfDhkPqeesekkriiaa.....gGfvelnrvngnLalsralgDfefkknvk..............kkpeeqivt

ARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALENYAREAQLPLDS
| |.||     . . ||..| ||.|||.  .  |. | . |..||.  . . .|....| . .... .  | 
avPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDn
PPM_PTC7_SpoIIE 137-405 1.2e-20 67.3 In-house 11-220 (230) alignment 
Range on Protein: 137-405
Range on HMM: 11-220/230.0
ANDPMEDRHSAH------SLGAHGVLVGMFDGHSGFAasDAASTFLSSYINKSLTNVPPnadelTICEALEQAFLDFDRDFTETvpnmalktgnsdviea
| ..|||.| .       | |  ...|| .||| | |   .|.. | . ...  ..  .     . .|.|. ..| ...|....                
arksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafagle.....kpeeilrrlnlalaadlede................

fvnPALAGAVSVNALIHPTG--IFVANTGDCRCVMGVRRGVghrpvimsidqtgdtpsEILRLqQEHPGEEesV-VRRGRVLGNLQPARAFGDSRYKWsr
   |.  ||  | |||.|.   . ||| ||.....    |                  |. |. ...   .  . .. ||| |.|. ..|.||  ..   
...psssgaTavvalidpstgklyvanaGdsppllvrddgg.................ereri.vagglps..lGilpgrvfgvlavslapGdlllly..

dlmqqlgvrvpngylTPPYVTARPEvlfYPHAPA---NAFLIMATDGLWDVVDPEAAVQTVSQALANGadalsAAGKLVHH
               |  .|.|.|.    ..      ..|||.|.||||||..|. .|..| . |        ||..|...
...............tDGvveaepd...tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleD
subfamily_PPM1G_pd Subfamily PPM1G 238-398 1.8e-18 59.8 In-house 297-439 (473) alignment 
Range on Protein: 238-398
Range on HMM: 297-439/473.0
GAVSVNALIHPTGIFVANTGDCRCVMGvRRGVghrPVIMSIDQTGDTPSEILRLQQEhpGEeeSVVRRGRVLGNLQPARAFGDSRYKWSRDLMQQLGVrv
|.  | ||..   ..||| ||.|||.  | |.    . .|.|   . . |  |...   |    |   ||| | |  .||.||  ||  ..| ..  .  
GttAvvaLlkekklivAnaGDsRcvls.rnGk...AldlslDHkPeDevEleRiekA..GG..kvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqm..

pngyltppyVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADA-LSA
         ..| |..     .... ||..|.||.|.|.. .  |. | . |..| .. ||.
.........isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlse
subfamily_PPM1D_pd Subfamily PPM1D 154-411 1e-16 53.9 In-house 35-291 (309) alignment 
Range on Protein: 154-411
Range on HMM: 35-291/309.0
GVLVGMFDGHSGFAASDAASTFLSSYINKSLTNvpPNADELTICEALEQAFLDFDRDFTETVPNMALKtgnsdvieAFVNPALAGAVSVNALIHPTGIFV
   |..|||| |  |.  |.  | |.|.|       . ..  ..||...|||.  .   ..  . . .        .  ... ||.     .|  . ..|
vafvavfDGHGGkeAakfarehlwsvikkqkkf..lssepedvleAireaflatheamkkkleeWpkt........ksgllstaGttasvviirreklyv

ANTGDCRCVMGVRRG--VGHRPVIMSIDQTGDTPSEILRLQQeHPGEEESVVRRGRVLGNLQPARAFGDsrykWSRDLMQQLGVRVPNGY------LTPP
|. || . |.||.       |.  .  |   ..|.|  |...   ||        ||  . .  .  |.      .| .  | |    |        .  
ahvGDsaivlgvkepkekklrakeltkdHkPespeekeriee.lGGevaaksGvkRvvWkRprlehngp....tvideiPFLavaRslGDlWsynaksge

Y-VTARPEVLFYPHAPANA-FLIMATDGLWDVVDPEAAVQTVSQALANGAD----ALSAAGKLVHHALENYA
. |   |.|  .   |..  |.|.|.||||.|. ||.||..|..  . .        | | .||..||....
fvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwr
subfamily_PDP_pd Subfamily PDP 132-185 1.7e-16 53.3 In-house 2-56 (398) alignment 
Range on Protein: 132-185
Range on HMM: 2-56/398.0
TAWLNANDPMEDRHS-AHSLGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLT
.. |..|.|.|||.| |..| ..|||.|.||||.|.|...| |. |..|...|| 
snqLasNePiEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaasll
subfamily_ILKAP_pd Subfamily ILKAP 147-395 1.8e-16 53.2 In-house 36-249 (293) alignment 
Range on Protein: 147-395
Range on HMM: 36-249/293.0
AHSLGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNADELTICEALEQAFLDFDRDFTETVPNMalKTGNSDvieafvnpalaGAVSVNALI
..|| ..    ..||||.|  ||. |.  |   | . |..   .| | .|  .| ..|   |..| ..  .   |    |           |.  .  |.
ekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaska..kPvWkd...........Gstatvvlv

HPTGIFVANTGDCRCVMGVRRGVGH--RPVIMSIDQTGDTPSEILRLQQEhpGeeeSVVRRGRVLGNLQPARAFGDSRYKwsrdlmqQLGvrvpngyltp
    ..||| || ..|.  .   |.    | .. | |  .  |  |.|.   |   .||| ||||| |. .|. || |.|       .||          
ldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqka..G...gvvrdgrvlGvlevsrsiGdgrfk.......rlG..........

pyVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADA
  |.. |.|      . . |...| ||||.|.. ...|. ....| .  | 
..vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeedd
subfamily_PDP_pd Subfamily PDP 397-445 2.6e-15 49.4 In-house 350-398 (398) alignment 
Range on Protein: 397-445
Range on HMM: 350-398/398.0
SAAGKLVHHALENYAREAQLPLDSLMEIPAGQARNFRDDITVTVVMLDS
.||..|..|||........  ...|..||...||..|||||||||...|
naAthLirhalggneagdkekvsallsiPeelaRmyRDDitvtVvffns
subfamily_PPM1L_pd Subfamily PPM1L 139-390 5.9e-15 48.2 In-house 17-237 (269) alignment 
Range on Protein: 139-390
Range on HMM: 17-237/269.0
DPMEDRHSAHS---LGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLTNVppnadeltI-------CealeqafldfdRDFTETVPNMALKTGNSDVI
. ||||   .     ...  ....|||| |  |.. |   |.  | . | ..                             .|.. . .  |   .  . 
prmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel........dadkentep...........infsklltdeilsvdeklle

EAFVNPALAGAVSVNALIHPTGIFVANTGDCRCVMGVRRGVGhrpVIMSIDQTGDTPSEILRLQQehPGEEESVVRRGRVLGNLQPARAFGDSRYKwsrD
.| ..  .||. .. ||.. . . ||| || | |.  .||     . .| |     . |  |...   |   .     || | |  .||.||   |   |
kakraediaGttalialvqesdlivanvGdsrGvlydkrGka...iplsfdhkpqqvkerkrikk..aGGfiafrGvwrvaGvlatsralGdyplk...d

lmQQLgvrvpngyltppyVTARPEVLFYPH-APANAFLIMATDGLWDVVDPEAAVQTVSQALA
  ..|             | | |..| .        |||.|.|||||    | ||. . . | 
..knl.............viadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 153-321 6.7e-13 41.5 In-house 35-175 (255) alignment 
Range on Protein: 153-321
Range on HMM: 35-175/255.0
HGVLVGMFDGHSGFAASDAASTFLSSYINKSLtNVPPNadelTICEALEQAFLDFDRDFtetvpnmalktgnsdvieaFVNPALAGAVSVNALIHPTGIF
.  .. .||||.| ||...||  |   ... | .. .     .  ..|..|. . .  .                      |   |. .. .||    ..
dedyyalfdGhgGraaakfaseelykilaell.dlnna....nPvkslkkaykeistqi...................serpkfiGttaasvliiedkvy

VANTGDCRCVMGVRRGVGHRpviMSIDQTGDTPSEILRLQQeHPGEEESVVRRGRVLGNLQPARAFGDS
.|| || | |.. . |. .|   .|.|     .|| .|...   |   | |   || |.|  .||.|||
ianvGdsrvvlcqkdgtakr...lsldhkPseeseekrise.lGGtvvstvvtsrvnGtlavsralGds
subfamily_KAPP-like_pd Subfamily KAPP-like 155-408 7.8e-12 37.8 In-house 35-251 (266) alignment 
Range on Protein: 155-408
Range on HMM: 35-251/266.0
VLVGMFDGHSGFAASDAASTFLSSYINKSLTNvppnadelTICEALEQAFLDFDRDFTETVPNMALKTGNSDVIEAFVNPALA---GavsvnaliHPTGI
 | ..||||.|  |.|||. ..   ..| | .        |  .   .   |  . . ... ..  |  . .   |    ||    |        .   .
alfavfdGhaGkGaadaakklfpkelekllks........tkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG........qqryl

FVANTGDCRCVMGvrrgVGHRPVIMSIDQTGDTPSEILRLQQEHPGEEESVVRrgrVLGnLQPARAFGDSRYKwsrdlMQQLgvrvpnGYLTPPYVTARp
 ||| ||    .      |   . .| |   . |.|. |....     ..  |   . | |  .||.||   |      ...      |  . |||. | 
qvanvGdssafls....rGneslelskdhkakdpeekqrikddGitlsdnqtr...inG.lavsralGdhfik.....elni......Glisepyvsnr.

evlfYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALE
    .  .| . |||.|.||||||.. . |.. |.    ..| . . |  |.. |..
....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiq
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 154-408 2.3e-11 36.1 In-house 33-261 (276) alignment 
Range on Protein: 154-408
Range on HMM: 33-261/276.0
GVLVGMFDGHSGFAASDAASTFLSSYINKSLTNvppNADELTICEALEQAFLDFDRDFTETVPNMALKTGNSDVIEAFVNPALAGAVS-VNALIHPTGIF
  | ..||||.|  |.|||. ..   ..| |         ||  .   .   |  . . .   ..  |  . .   |    ||       .   .   . 
ialfavfdGhaGkGaadaakklfpkelekllks...gnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylq

VANTGDCRCVMGvrrgVGHRPVIMSIDQTGDTPSEILRLQQEHPGEEESVVRrgrVLGnLQPARAFGDSRYKwsrdlMQQLgvrvpnGYLTPPYVTARpe
||| ||    .      |   . .| |   . |.|. |....     ..  |   . | |  .||.||   |      ...      |  . |||. |  
vanvGdssafls....rGneslelskdhkatdpeekqrikddGitlsdnqtr...inG.lavsralGdhfik.....elni......Glisepyvsnr..

vlfYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALSAAGKLVHHALE
   .  .| . |||.|.||||||.. . |.. |.    ..| . . |  |.. |..
...illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiq
subfamily_PPM1K_pd Subfamily PPM1K 142-405 6.5e-11 34.8 In-house 19-241 (263) alignment 
Range on Protein: 142-405
Range on HMM: 19-241/263.0
EDRHSAHSLGAHGVLVGMFDGHSGFAASDAASTFLSSYINKSLtnvpPNADELTicEALEQAFLDFDRDFTETVPNMALKTgnsdvieafvNPALAG-AV
||| . . |  . . |..||||.| || | . . |   ... |    .. ..|   . | .||.. |....  .  .  ..          .   .| . 
edriklkeldpellyvavfdGhaGsaaadfvhdklekilkrll....ekekdle..ivlknafeeldkklkrylefsvaea..........ellssGtta

SVNALIHPTGIFVANTGDCRCVMgVRRGvghRPVIMSIDQTGDTPSEILRLQQEHPGEEESVVRRGRVLGNLQPARAFGDSRYKwsrdlmqQLGVrvpng
.|  | . | . .|..|| | ..  |.|   ..  ...| . .   |  |...     | . . . .| | |  .|..||   |       . ||     
tvsllrdGtelvlaslGdsrail.crnG...kakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk.......ryGv.....

yLTPPYvTARPEVlfyPHApANAFLIMATDGLWDVVDPEAAVQTVSQAlangADALSAAGKLVHH
 .. |  | . .|    || |..||.. |||. .||. .   . |..      |   ||  |.. 
.iatPe.tkslkv...dha.adsflvlitdgisfvvnsqelcdlvrlc....hdpeeaahalteq
subfamily_PPM1E_pd Subfamily PPM1E 345-409 2.1e-10 33.2 In-house 184-249 (265) alignment 
Range on Protein: 345-409
Range on HMM: 184-249/265.0
PYVTARPEVLFYPHAPANAFLIMATDGLWDVVDPEAAVQTVSQALANGA-DALSAAGKLVHHALEN
|||.. ..|  ..   .. .||.|.|||||||..| .|..|.. ||.|| |  ..| .||..| |.
pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakea
subfamily_TAB1_pd Subfamily TAB1 237-376 2.5e-10 32.7 In-house 129-260 (333) alignment 
Range on Protein: 237-376
Range on HMM: 129-260/333.0
AGAVSVNALIHPTGIFVANTGDCRCVMGVRRGvGHRPVIMSIDQTGDTPSEILRLQQehPGEEESVVRRGRVLGNLQPARAFGDSRYKWSRDLMQQLgvr
 |.  | |||.   ..||| || | ..  |.   .. . .| | | | . |.|||..   | .   ..| ..||. .. |. || . |   . .. |   
gGttAvvalifnnkLyVaNvGdsrAllvkrke.sekvkqLsvdHttdNedEllRlkd..LGldieqikrnkrlgskentRsiGdykvkkgykdvdil...

vpNGYLTPPyVTARPEVLFY-PHAPANAFLIMATDGLWDVV
       .| | | |..    |  ..  ||..  ||.   .
..ssakgeP.viaePdiqgaypiddityflvlmSdGvyktL
PPM_PTC7_motif 366-408 7.3e-10 32.2 In-house 1-44 (51) alignment 
Range on Protein: 366-408
Range on HMM: 1-44/51.0
IMATDGLWDVVDPEAAVQTVSQALA-NGADALSAAGKLVHHALE
|.|.||||||.... ||. | . |. .| .  .|| ||| .||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdeala
PP2C_2 Protein phosphatase 2C 136-392 3.2e-09 29.4 Pfam-A 7-197 (212) alignment 
Range on Protein: 136-392
Range on HMM: 7-197/212.0
NANDPMEDRHSAHSLGAHGVLvGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNADELTICEALEQAFLDFDRDFTetvpnmalktG-NSDVI-EAfvN
... | .|..  ..  .  .|  . ||..  . || .. .. . . ..|..   ...| .. ..|.|.  . ... .            ..    ..  .
rkgkpcqDalaireasdgwll.aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk..........lkqeaeaqqe..e

PALAGAVSVNALIHPTGIFVANTGDCRCVMGVrrgVGHRPVIMSIDQTGDTPSEILRLQQEHPGEEEsvvrrgrvlgnlqparafgdsrykwsrdlmqql
.   ..  . |.|.|..|.... ||...|.       ..  .......|.  .|  .|..| ..||                                  
lkdyatTlllavitpgeivffqiGDgaivvrd...rdgevqllgepdsgeyanettfltsedaeeel.................................

gvrvpngyltppyvtarpEVLFYPhAPANAFLIMATDGLWDVVDPEAAVQTVSQALANG
                  ..   . ....  |.. |||..| . .|...... . | . 
..................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet
PP2C_2 Protein phosphatase 2C 136-392 3.2e-09 29.4 In-house 7-197 (212) alignment 
Range on Protein: 136-392
Range on HMM: 7-197/212.0
NANDPMEDRHSAHSLGAHGVLvGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNADELTICEALEQAFLDFDRDFTetvpnmalktG-NSDVI-EAfvN
... | .|..  ..  .  .|  . ||..  . || .. .. . . ..|..   ...| .. ..|.|.  . ... .            ..    ..  .
rkgkpcqDalaireasdgwll.aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk..........lkqeaeaqqe..e

PALAGAVSVNALIHPTGIFVANTGDCRCVMGVrrgVGHRPVIMSIDQTGDTPSEILRLQQEHPGEEEsvvrrgrvlgnlqparafgdsrykwsrdlmqql
.   ..  . |.|.|..|.... ||...|.       ..  .......|.  .|  .|..| ..||                                  
lkdyatTlllavitpgeivffqiGDgaivvrd...rdgevqllgepdsgeyanettfltsedaeeel.................................

gvrvpngyltppyvtarpEVLFYPhAPANAFLIMATDGLWDVVDPEAAVQTVSQALANG
                  ..   . ....  |.. |||..| . .|...... . | . 
..................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet
subfamily_PPM1H_pd Subfamily PPM1H 304-442 1.5e-08 26.9 In-house 273-401 (404) alignment 
Range on Protein: 304-442
Range on HMM: 273-401/404.0
RRGRVLGNLQPARAFGDSRYKWSRdlmQQLGVRvpngyltpPYVTARPEVLFYPH----APANAFLIMATDGLWDVVDPEAAVQTVSQALANGADALS--
.. |.|. .  .| .||   |      ..| ..        |.... |||  .         .  ||.||||||||.. |.. ..|.. |..  .. .  
kkaRllatigvtRGlGDheLkvvd...tnlsik........PfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkr

---AAGKLVHHALENYAREAqlpldslMEIPAgQARNFRDDITVTVVM
   .| .||..|  . ....         .   ..    |||.| |. 
ytavaqeLvaaarGklkdkg.......Wrlke.ekaasvDDisvfviP
PPM_PTC7_SpoIIE_motif 361-441 6.7e-08 26.1 In-house 11-78 (81) alignment 
Range on Protein: 361-441
Range on HMM: 11-78/81.0
ANAFLIMATDGLW-------DVVDPEAAVQTVSQAlaNGADALSAAGKLVHHALEnyareaqlpldslmeipaGQARNFRDDITVTVV
.   |...||||.       .....|........|   | .. ..| |||...||                   .... .||||. |.
pgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle..................ngsgereDDitllvl
subfamily_PPM1E_pd Subfamily PPM1E 156-324 7.8e-08 24.8 In-house 42-183 (265) alignment 
Range on Protein: 156-324
Range on HMM: 42-183/265.0
LVGMFDGHSGFAASDAASTFLSSYINKSLTNVPPNAdelticEALEQAFLDFDRDFTETVPNMALKtgnsdvieafvnpalAGAVSVNALIHPTGIFVAN
  ..||||.|  |.. |.. | . . .  .     |      |||..||   |. |...  . .||               .|. .| .||.   ..|| 
ffavfDGHgGveaakyaaahlhellvrqeklkedpa......ealkeafkltDerflqkaereklk...............sGstavvvliekdqlyvaW

TGDCRCVMgVRRGvghRPVIMSIDQTGDTPSEILRLQQEhpGEEESVVRRGRVLGNLQPARAFGDSRYK
 || . .. || |   . | .      . . |  |...   |    |.   || |.|. .|| || ..|
lGDsqall.vrkg...eavqlmkpHkPeredEkkRieea..gGlvvvigawRvnGvLsvsRaiGDvklk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 341-404 9.8e-08 24.6 In-house 176-235 (255) alignment 
Range on Protein: 341-404
Range on HMM: 176-235/255.0
YLTpPYVTARPEVL-FYPHAPANAFLIMATDGLWDVVDPEAAVQTVsqalANGADALSAAGKLVH
.|. |.|.. |..   .     . |||.| ||.||..  | ||..|    |. .|.  || ||  
fle.PfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrd
PP2C_SIG_SM00331 362-441 1.6e-06 20.9 In-house 150-215 (217) alignment 
Range on Protein: 362-441
Range on HMM: 150-215/217.0
NAFLIMATDGLWDVVDPEA----AVQTVSQALAngadaLSAAGKLVH---HALENYAREA-QlpldslmeipagqarnfRDDITVTVV
  .|...||||.... ..      .... ..|.      |.| .| .     |...|... .                 .||||| ||
gdllllytDGltearsekgfaeerleeiledlv.....dseaqelaqkiveellelakgsng.................eDdiTvvvv