Gene PPM1K in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1K
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP126_AA protein Get Run
MbreP126_AA_239-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 253-425 9.3e-87 284.2 In-house 1-196 (292) alignment 
Range on Protein: 253-425
Range on HMM: 1-196/292.0
AAGKLENHDRFCLVH-TEPLTF-AAVFDGHG--GDAVAQLAADHFEHQLTSLTPPLQETPPALLLRILqDIGAQWDELYAQHGLRAGTTATCAIVRDD-A
||.|.||.|||.||. .|.||| |||.||||  ||.|||||.|..|..|..||..|||...||||||| ||.|..|.|.......|.|...||.|||| |
aankkenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvrddra

LYLAQVGDSQALLYR-----DNELRPVTPSHRPEDPDEEARILAAGGRIT--------WRGTPRV------NGDLSMTRALGACHLRAAGVISDPAL
|.||.||||.|||.|     |.||.|....|.||||||.||||.||||..        .|||.||      .|||...||||..||..|||...|.|
lilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
0034914 PP2C-like 240-493 2.2e-60 196.9 In-house 16-293 (295) alignment 
Range on Protein: 240-493
Range on HMM: 16-293/295.0
LLHTFPAIGHFTDAAGKLENHDRFCLVH-----TEPLTFAAVFDGHGGDAVAQLAADHFEHQLTSLTPPL---QETPPALLLRILQDIGAQWDELYAQHG
.|  .  .|...|   . .| |... |.     .|.|....|||||||.|.|..|.... . | .|   |    ....  ....|...  . || . ...
slllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellela

LR------AGTTATCAIVRDDALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITWrgtPRVNGDLSMTRALGACHLR--------AA
|.       ||||..|..|.. ||.|.||||.|.|.|..||...|  |.| ...| .|||.|||....   .|||| | .|||||  .|           
llrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllsllllep

GVISDPALVSLELH-QDDAFLCLATDGVLDVVLPQEIVALCQQ----SGSPEAAAKAIGELALAYGSPDNTTVLILPLAGW
.|.. | . .|||. .|| ||.||.||. ||. ..|||.....    . ..|.||... .||||.|| ||.||... | |.
lvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1K_pd Subfamily PPM1K 252-494 3.1e-55 180.1 In-house 11-262 (263) alignment 
Range on Protein: 252-494
Range on HMM: 11-262/263.0
DAAGKLENHDRFCLVHTEP-LTFAAVFDGHGGDAVAQLAADHFEHQLTSLTpPLQETPPALLLRILQDIGAQWDELYAQH-----GLRAGTTATCAIVRD
    . || ||..| . .| | . ||||||.| | |. . |..|. |. |  . ..    .| . ....  .       .      | .||||| ...||
liGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrd

D-ALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITWR--GTPRVNGDLSMTRALGACHLRAAGVISDPALVSLEL-HQDDAFLCLAT
   | ||..|||.|.| |. . . .|  | ||  .|. ||.||||...|   | |.||| |.|||.||   |.  |||..|   ||.. |..|.|| | |
GtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlit

DGVLDVVLPQEIVALCQQSGSPEAAAKAIGELALAYGSPDNTTVLILPLAGWH
||. .||  ||.  | ..   || ||.|. | || ||| ||.|....||  | 
dgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvplgawg
0049733 PP2C-like 249-489 4.4e-49 159.9 In-house 7-232 (235) alignment 
Range on Protein: 249-489
Range on HMM: 7-232/235.0
HFTDAAG-KLENHDRFCLvhtePLTFAAVFDGHGGDAVAQLAADHFEHQLTSL-TPPLQETPPALLLRILQDIGAQWDELYAQH--GLRAGTTATCAIVR
...|    . .| |....     |...||.||||| |....|.... . | .|  ..| ... ..| .... . ... ||. ..    . ||||..|...
aasdigrvrkvneDavlv....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalld

DDALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRItwrgtpRVNGDLSMTRALGACHLRaagvisdPALVSLELHQDDaFLCLATDGV
.. ||.|.|||| |.|.||..|...|  |.| ...| .||..|||..      ||.| | .|||||  .|        | ...|||...| || ||.||.
ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk.......pdvtvlelepgd.flllasDGl

LDVVLPQEIVALCQQsGSPEAAAKAIGELALAYGSPDNTTVLILP
 ||. ..|||.|...  ..|.||... |||||.|..||.||... 
wdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvr
subfamily_PPM1E_pd Subfamily PPM1E 267-488 5e-49 159.9 In-house 36-260 (265) alignment 
Range on Protein: 267-488
Range on HMM: 36-260/265.0
HTEPLTFAAVFDGHGGDAVAQLAADHFEHqLTSLTPPLQETPPALLLRILQDIGAQWDELYAQHGLRAGTTATCAIVRDDALYLAQVGDSQALLYRDNEL
 ... .| ||||||||   |. || |  . |.   . |.| |   | . .. .  .  .  .. .|..|.|| ..... |.||.| .||||||| |. | 
dekeraffavfDGHgGveaakyaaahlhe.llvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgea

RPVTPSHRPEDPDEEARILAAGGRITWRGTPRVNGDLSMTRALGACHLRAAgVISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALCQQS-----G
. ..  |.||..||..|| .||| . . |. |||| ||..||.|  .|..  |.... ....||.... .| ||.||. ||| ..|.| | ...     .
vqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgae

SPEAAAKAIGELALAYGSPDNTTVLIL
. . .|| . | |   || || ||.. 
dlsevakllveaakeagssDnitvvvv
PP2Cc_SM00332 261-487 1.4e-48 158.6 In-house 30-273 (274) alignment 
Range on Protein: 261-487
Range on HMM: 30-273/274.0
DRFCLVHTEPLTFAAVFDGHGGDAVAQLAADHFEHQLTSLTPPLQETPPALLLRILQDIGAQWDELYAQHG----L---RAGTTATCAIVRDDALYLAQV
 ...||. |  .| .|||||||..||....... . | .     ...      ..|..   . || . ..     |   ..|.||..|..... ||.|.|
vvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenalsGstavvallkkedlyvanv

GDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITWRgtpRVNGDLSMTRALGACHLRA------AGVISDPALVSLELHQDDAFLCLATDGVLDV
|||.| |.|... ....  |.|||.|| .|| .||| . ..   ||||.|...||.|. .| .       .....|    ..| ..| || ||.||. ||
GDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdv

VLPQEIVALCQQSG------SPEAAAKAIGELALAY-GSPDNTTVLI
. .||.| ....        .|..||. . |.|... || ||.||..
lsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvv
PPM_PTC7 269-483 4.9e-47 153.5 In-house 32-259 (259) alignment 
Range on Protein: 269-483
Range on HMM: 32-259/259.0
EPLTFAAVFDGHGGDAVAQLAADHFE--HQLTSLTPPLQETPPALLLRILQDIGAQWDELYAQ--HGLRAGTTATCAIVRDDALYLAQVGDSQALLYRDN
..  | ||||||||. .|..|. |.|   .. .  ..|...  ||   .|..  ... .. ..  . .. |.||..|..... || |.||||.|.| |..
dsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsg

ELR-PVTPSHRPEDPDEEARILAAGGRITWRGTPRVNGDLSMTRALGACHLRA-----AGVISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALCQ
. . ..| .|.|...|| .|| .|||.. . |  |||| | ..||.|  .|         |...|   | ..  .| || ||.||. ||| .||.| |..
navkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvr

QSGS---PEAAAKAIGELALAYGSPDNT
.  |   |. ||... . |.|.|| ||.
selskkdpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 267-483 1.8e-46 151.8 Pfam-A 30-255 (255) alignment 
Range on Protein: 267-483
Range on HMM: 30-255/255.0
HTEPLTFAAVFDGHGGDAVAQLAADHFEhQLTSLTPPLQET---PPALLLRILQdIGAQWDELYAQ--HGLRAGTTATCAIVRDDALYLAQVGDSQALLY
. ..  | ||||||||. .|..|. | | ..  . . ..|      ||   .|.   ... .. ..  . .. |.||..|..|.. ||.|.||||.|.| 
gkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfla.dtdeelksskantepsksGstavvalirgkklyvAnvGDSravLc

RDNELR-PVTPSHRPEDPDEEARILAAGGRITWrgTPRVNGDLSMTRALGACHLRA---AGVISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALC
|... .  .|  |.|.|.|| .|| .|||.. .    |||| |...||||  .|     . |...| . | .| ..| || ||.||. ||. .||.| |.
rkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlv

QQSGS----PEAAAKAIGELALAYGSPDNT
..  |    |. ||... . |.|.|| ||.
rselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 267-483 1.8e-46 151.8 In-house 30-255 (255) alignment 
Range on Protein: 267-483
Range on HMM: 30-255/255.0
HTEPLTFAAVFDGHGGDAVAQLAADHFEhQLTSLTPPLQET---PPALLLRILQdIGAQWDELYAQ--HGLRAGTTATCAIVRDDALYLAQVGDSQALLY
. ..  | ||||||||. .|..|. | | ..  . . ..|      ||   .|.   ... .. ..  . .. |.||..|..|.. ||.|.||||.|.| 
gkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfla.dtdeelksskantepsksGstavvalirgkklyvAnvGDSravLc

RDNELR-PVTPSHRPEDPDEEARILAAGGRITWrgTPRVNGDLSMTRALGACHLRA---AGVISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALC
|... .  .|  |.|.|.|| .|| .|||.. .    |||| |...||||  .|     . |...| . | .| ..| || ||.||. ||. .||.| |.
rkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlv

QQSGS----PEAAAKAIGELALAYGSPDNT
..  |    |. ||... . |.|.|| ||.
rselskkkspmeaaeelvdeaiargsedni
subfamily_PPM1A_pd Subfamily PPM1A 261-490 1.1e-41 136.0 In-house 28-280 (282) alignment 
Range on Protein: 261-490
Range on HMM: 28-280/282.0
DRFCLVHT----EPLTFAAVFDGHGGDAVAQLAADHFEHQLTS---L-TPPLQETPPALLLRILQDIGAQWD----ELYAQH--GLRAGTTATCAIVRDD
|... | .    .  .| ||||||.|. ||. ...|. .....   |    |....   ..  |..   . |    || ...   ...|.||....|...
DahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvlvsek

ALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITwrgTPRVNGDLSMTRALGACHLRA--------AGVISDPALVSLELHQDDAFLC
 |..|..||| |.|.|...    |  |.|..|.|. || .||| ..   . |||| | ..||||  ...           |...|   |.| ...| || 
hliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflv

LATDGVLDVVLPQEIVALCQQS----GSPEAAAKAIGELALAYGSPDNTTVLILPL
|| ||. ||.  .|.|.| ...      .|. |||. . ||  || || .||.. .
lacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 273-490 8.3e-41 132.9 In-house 38-253 (255) alignment 
Range on Protein: 273-490
Range on HMM: 38-253/255.0
FAAVFDGHGGDAVAQLAADHFEHQLTSLTPPLQETPPALLLRILQDIGAQWdelyAQHGLRAGTTATCAIVRDDALYLAQVGDSQALLY-RDNELRPVTP
. |.||||||.| |. |...... |..|    . .|   | .  ..|  |     .... . ||||. ... .|  |.| ||||...|  .|   . .. 
yyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsl

SHRPEDPDEEARILAAGGRITWR-GTPRVNGDLSMTRALGACHLRAaGVISDPALV-SLELHQDDAFLCLATDGVLDVVLPQEIVALCQQSGSPEAAAKA
 |.| ...|| || ..|| .     | |||| |...||||  .|    |..|| |  ||| ...| || || ||. |..  .| | .  .. .|| ||. 
dhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfleP.fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaaek

IGELALAYGSPDNTTVLILPL
. .||   || || .|... |
lrdlayssGstdnisvivikl
subfamily_PPM1G2_pd Subfamily PPM1G2 267-470 7.3e-32 103.4 In-house 48-256 (287) alignment 
Range on Protein: 267-470
Range on HMM: 48-256/287.0
HTEPLTFAAVFDGHGGDAVAQLAADHFEHQLTSltppLQETPPALLLRILQDIGAQWDELYAQH----GLRAGTTATCAIVRDDALYLAQVGDSQALLYR
 .. |.. ||||||||..||. |. .. . ...     ..     | .||.|   . ||   ..       ||.||. ...... || | .|||.|.|  
ddkslalfavfDGhGGakvakyagkklikkiak....kksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlss

DNELRPVTPSHRPEDPDEEARILAAGGRITwrgTPRVNGDLSMTRALGACHLRAAG--------VISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIV
. ... ..  |.|.. .|. || |||| .      |||| |.. ||||  . .           |   | ..  .|..|| || || ||. ||.  .|.|
kgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevv

ALCQQSGSPEAAAKAI
 |...  . .|. ..|
dlvrerlvsgakldei
subfamily_PPM1L_pd Subfamily PPM1L 271-489 4.5e-31 101.1 In-house 35-265 (269) alignment 
Range on Protein: 271-489
Range on HMM: 35-265/269.0
LTFAAVFDGHGGDAVAQLAADHFEHQLT----SLTPPLQETPPALLLRILQD-IGAQWDELYAQ---HGLRAGTTATCAIVRDDALYLAQVGDSQALLYR
 .| ||||||||.  |. | | . ...      |    ..| |    ..|.| | .   .|  .       |||||  |.|... | .|.||||. .|| 
esffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlyd

-DNELRPVTPSHRPEDPDEEARILAAGGRITWRGTPRVNGDLSMTRALGACHLRAAG-VISDPALVSLELHQD-DAFLCLATDGVLDVVLPQEIVALCQ-
 . .  |..  |.|... |  ||  ||| |..||. ||.| |...||||   |.    ||.|| .....|..    || ||.||. |    .| |   . 
krGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfike

QSGSPEAAAKAIGELALAYGSPDNTTVLILP
. . |.  ||..   .   ||.|| |||.. 
rlkepdfGakslvlesfkrGsvdnitvlvvk
subfamily_ILKAP_pd Subfamily ILKAP 271-459 6e-27 87.6 In-house 43-241 (293) alignment 
Range on Protein: 271-459
Range on HMM: 43-241/293.0
LTFAAVFDGHGGDAVAQLAADHFEHQLTSLTPPlQETPP--ALLLRILQDIGAQWDELYAQH------GLRAGTTATCAIVRDDALYLAQVGDSQALLYR
... ||||||.|.  .. ||....... .  |  ...      . . | |  .. || . .         . |.|||. .| |. || | .|||.|.|.|
vsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvr

DNELR------PVTPSHRPEDPDEEARILAAGGRITwrgTPRVNGDLSMTRALGACHLRAAGVISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVAL
 .|        ..|  | | . .|  ||  ||| ..     ||.| | ..|..|  . . .|||| | .  .|| ..| |. || ||. .|.  .|.|  
kkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr...dgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkf

CQQ
...
ilk
subfamily_PPM1G_pd Subfamily PPM1G 328-459 2.4e-23 75.9 In-house 290-427 (473) alignment 
Range on Protein: 328-459
Range on HMM: 290-427/473.0
AQHGLRAGTTATCAIVRDDALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITWRGtpRVNGDLSMTRALGACHLRAA-------GVI
 . |  .||||. |..... |. | .||| . | |. .   .   |.|||. | .|| .|||...  |  |||| | . ||||    .          .|
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmi

S-DPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALCQQ
|  | .  |.| ..| || ||.||. .|.  ||.|   ..
sAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvra
subfamily_PPM1D_pd Subfamily PPM1D 270-462 5.6e-23 74.5 In-house 34-266 (309) alignment 
Range on Protein: 270-462
Range on HMM: 34-266/309.0
PLTFAAVFDGHGGDAVAQLAADHFEHQLTSLTPPLQETPPALLLR----------ILQDIGAQWDELYAQHGLRAGTTATCAIVRDDALYLAQVGDSQAL
  .| ||||||||   |. | .|  ....  .  |.. |...|             ..   ..| .   ..   |||||.. |.|.. ||.|.||||...
evafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaiv

LYRDNE------LRPVTPSHRPEDPDEEARILAAGGRITWR-GTPRV---------NGD--------LSMTRALGACH---LRAA--GVISDPALVSLEL
|  ...       ...| .|.||.|.|. ||  .||... . |  ||         ||.        |...|.||       .     |  .| ..  .|
lgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtl

HQDDA-FLCLATDGVLDVVLPQEIVALCQQSGS
....  |. ||.||. .|. |.. | ..... .
dpneekfiilasDGlwnvltpedavsvvekeee
PPM_PTC7_SpoIIE 273-479 2.7e-21 69.4 In-house 36-226 (230) alignment 
Range on Protein: 273-479
Range on HMM: 36-226/230.0
FAAVFDGHGGDAvaQLAADHFEHQLTSLTPPLQETPPALLLRILQDI-GAQWDElyaqhGLRAGTTATCAIVRDDA--LYLAQVGDSQALLYRDNELrpv
. ...|||||.|  .||. ..   | .|  .  |.| ..| |. . .  . .||         |.||..|... .   ||.|..||| .||.||..    
vvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede.....psssgaTavvalidpstgklyvanaGdsppllvrddgg...

tpshrpedpdEEARIlAAGGRITwRGT--PRVNGDLSMTRALGACHLRA-AGVISDPA-LVSLELHQDDAFLCLATDGVLDVVLPQEIVALCQQSGSPEa
          |. || .||| .   |    ||.|.|....| |   | .  ||..  .  .  || ..|.|| ||.||. ||. |||.| |.... ..  
..........ereri.vagglps.lGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.

AAKAIGELALAYGS
||....| ......
aaeglleDDitllv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 426-481 5.1e-21 68.5 In-house 239-292 (292) alignment 
Range on Protein: 426-481
Range on HMM: 239-292/292.0
VSLELHQDDAFLCLATDGVLDVVLPQEIVALCQQsgSPEAAAKAIGELALAYGSPD
...||..|||||.||.||||||.|..|.|.|...  |.|||.|.|.||||.||..|
lekeldsddaflvlasdGvldvllnaevvlllak..sqeaadkvitelaleyglsd
PP2C_SIG_SM00331 260-488 8.2e-18 57.7 In-house 18-215 (217) alignment 
Range on Protein: 260-488
Range on HMM: 18-215/217.0
HDRFCLVHTEP-LTFAAVFDGHGGDAVAQLAADHFEHQLTSLTPPLqETPPALLLRILQDIGAQwdelyaQHGLRAGTTATCAIV--RDDALYLAQVGDS
.| ...| ..   ....|.||.|... |..|.  . . |  |     |... .| |. . | ..      ..  . ..|...|..  ... |..| .|||
GDyydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.eelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaGds

QALLYRDNELRPVTPShrpedpdeearilaaggritwrgtprvngdlsmtralgaCHLRAAGVISDPA--LVSLELHQDDAFLcLATDGVLDVVLPQE--
  .|.||..|   . .                                          ...|.....     .|||...| .| |.|||. ... ...  
rpyllrdgklveilkd.......................................vegaplGlepevsvdirelelekgdlll.lytDGltearsekgfa

----IVALCQQSGSPEAAAKA-----IGELALAYGSPDNTTVLIL
    . .|..  .|. .. ..     . ||| ... .|. ||...
eerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PP2D1_pd Subfamily PP2D1 344-459 1.1e-17 56.9 In-house 186-304 (492) alignment 
Range on Protein: 344-459
Range on HMM: 186-304/492.0
RDDALYLAQVGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITWRG-TPRVNGDLSMTRALGA---CHLRAAgVISDPALVSLELHQDDAFLCL
    ||.|..|. ||.| |. .   .|  | |... |  |.  ||. ..  . . .||| |. || ||     .|. . || .| . | .| . . || |
elgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkks.vipePkttsvkldeaaqflvl

ATDGVLDVVLPQEIVALCQQ
|. |. .|.  .|...| .|
AsnGlWevlseeevlsLvkq
subfamily_KAPP-like_pd Subfamily KAPP-like 272-487 5.3e-17 54.7 In-house 35-263 (266) alignment 
Range on Protein: 272-487
Range on HMM: 35-263/266.0
TFAAVFDGHGGDAVAQLAADHFEHQLTSLTPP-LQET---PPALLLRILQDIGAQWDELYAQHGLRaGTTATCAIV-RDDALYL---AQVGDSQALLYRD
.. |||||| |  .|. | . |...|  |     |.    .     ..|..   . |.   ..    |.||| |.| .|    .   |.|||| |.| | 
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.GatatlalvwsdGqqrylqvanvGdssaflsrG

NELRPVTPSHRPEDPDEEARILAAGGRITwRGTPRVNGdLSMTRALGACHLR--AAGVISDPALV-SLELHQDDAFLCLATDGVLDVVLPQEI---VA-L
||   ..  |. .||.|  ||   |  ..  .  |.|| | ..||||   ..    |.||.| .   . |   | || .|.||. ||.  ..    |  |
neslelskdhkakdpeekqrikddGitls.dnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvksl

CQQSGSPEAAAKAIGELALAY-GSPDNTTVLI
 .|  . .  |... | |.    . || .|..
ydqqatedkmasslletaiqsikakdnvsviv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 272-487 1.4e-15 49.9 In-house 34-273 (276) alignment 
Range on Protein: 272-487
Range on HMM: 34-273/276.0
TFAAVFDGHGGDAVAQLAADHFEHQLTSLTPP--------LQET-PPALLLRILQDIGAQWDELYAQHGLRaGTTATCAIVRDDA----------LYLAQ
.. |||||| |  .|. | . | ..|  |            .   .     ..|.|.  . |.   ..    |.||| |.|  |           |  |.
alfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeye.GatatlalvwsdGeeqqqqqqrylqvan

VGDSQALLYRDNELRPVTPSHRPEDPDEEARILAAGGRITwRGTPRVNGdLSMTRALGACHLR--AAGVISDPALV-SLELHQDDAFLCLATDGVLDVVL
|||| |.| | ||   ..  |. .||.|  ||   |  ..  .  |.|| | ..||||   ..    |.||.| .   . |   | || .|.||. ||. 
vGdssaflsrGneslelskdhkatdpeekqrikddGitls.dnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvis

PQEIV---A-LCQQSGSPEAAAKAIGELALAY-GSPDNTTVLI
 .. .     | .|  . .  |... | |.    . || .|..
Gkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv
subfamily_PHLPP_pd Subfamily PHLPP 347-489 3.4e-12 38.8 In-house 106-244 (246) alignment 
Range on Protein: 347-489
Range on HMM: 106-244/246.0
ALYLAQVGDSQALLYRDNELRPVTPSHRPEDpDEEARILAAGGRITWRGtpRVNGDLSMTRALGACHLRaAGVISDPALVSLELHQDDAFLCLATDGVLD
 | .|.||  || | |...  ... |.  |. ||  ||  | . ||  .  ..|| .. || ||  .|    |. .| . .. | ..| .| .  . . .
sLevAsvGtlqavliRngkklrlsksyviek.delkrikeakaiitedn..kingviestrllGytflf.PvvlPkphvrevlLteqdellivGnkalWe

VVLPQEIVALCQQSGSPEAAAKAIGELALAYGSPDNTTVLILP
|.  .|.|   ..  .| .||| . .|| .||  |. .||.. 
vlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvr
PP2C_2 Protein phosphatase 2C 255-446 9.1e-11 34.4 Pfam-A 8-179 (212) alignment 
Range on Protein: 255-446
Range on HMM: 8-179/212.0
GKLENHDRFCLVHTEPLTFAAVFDGHGGDAV----AQLAADHFEHQLTSLTPPLQET-PPALLLRILQDIGAQW-----DELYAQHGLRAGTTATCAIVR
... . |..   ...   ..|| ||.| ..     |.||.  . ..|..|    .|.   ||| .|...| |..      |   .     .|| ..|...
kgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavit

DDALYLAQVGDSQALL-YRDNELRPVTPSHRPEDPDEEARILAAGGRITWrgtprvngdlsmtralgachlraagvisdpALVSLElHQDDAFLCLATDG
.. ....|.||. ...  ||.|..... ..  |   |  ..  .    ..                               . .|.  ..   |.| |||
pgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................rirrlk.lepgdalllmTDG

VLD
| |
vsd
PP2C_2 Protein phosphatase 2C 255-446 9.1e-11 34.4 In-house 8-179 (212) alignment 
Range on Protein: 255-446
Range on HMM: 8-179/212.0
GKLENHDRFCLVHTEPLTFAAVFDGHGGDAV----AQLAADHFEHQLTSLTPPLQET-PPALLLRILQDIGAQW-----DELYAQHGLRAGTTATCAIVR
... . |..   ...   ..|| ||.| ..     |.||.  . ..|..|    .|.   ||| .|...| |..      |   .     .|| ..|...
kgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavit

DDALYLAQVGDSQALL-YRDNELRPVTPSHRPEDPDEEARILAAGGRITWrgtprvngdlsmtralgachlraagvisdpALVSLElHQDDAFLCLATDG
.. ....|.||. ...  ||.|..... ..  |   |  ..  .    ..                               . .|.  ..   |.| |||
pgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................rirrlk.lepgdalllmTDG

VLD
| |
vsd
subfamily_TAB1_pd Subfamily TAB1 330-412 3.9e-08 25.4 In-house 125-210 (333) alignment 
Range on Protein: 330-412
Range on HMM: 125-210/333.0
HGLRAGTTATCAIVRDDALYLAQVGDSQALLYR---DNELRPVTPSHRPEDPDEEARILAAGGRITWRGTPRVNGDLSMTRALGAC
. .. ||||  |..  . || | ||||.||| .    .. . .   |  . .||  |.   |  |      .. |.   ||..|  
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdy
PPM_PTC7_motif 439-483 6.1e-08 26.1 In-house 2-51 (51) alignment 
Range on Protein: 439-483
Range on HMM: 2-51/51.0
LATDGVLDVVLPQEIVALCQQSGS-----PEAAAKAIGELALAYGSPDNT
||.||. ||. .||.| |...  |     |. ||. . . |||.|| ||.
LAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PPM_PTC7_SpoIIE_motif 434-488 6.6e-07 22.9 In-house 12-78 (81) alignment 
Range on Protein: 434-488
Range on HMM: 12-78/81.0
DAFLCLATDGVL-------DVVLPQEIVALCQ--QSGSPEAAAKAIGELALAYG---SPDNTTVLIL
.  | |.|||.        ......| ..|..  ...|.. .|... . .|..|   . |..|.|.|
gdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl
Subfamily Dicty-PPM1L-like 380-491 1.6e-06 20.2 In-house 182-304 (305) alignment 
Range on Protein: 380-491
Range on HMM: 182-304/305.0
EEARILAAGGRITWRGTPRVNGDLSMTRALGACHLRAAgVISDPALVSLEL-HQDDAFLCLATDGVLDVVLPQEIVA----LCQQSGS-------PEAAA
.  ||  ... .   |. .||. |.  |  |   |.   || ...   | . . .| || |||||. .|.  |..|     | ... |       ..   
iririeslqaalynygellvnrllkksrskGdknlkel.viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneis

KAIGELALAYGSPDNTTVLILPLA
. |.|.|.  || ||.|..|..| 
rviveeavkrgsgDnitlviiklk
subfamily_PDP_pd Subfamily PDP 420-460 2.1e-06 20.1 In-house 271-311 (398) alignment 
Range on Protein: 420-460
Range on HMM: 271-311/398.0
ISDPALVSLELHQDDAFLCLATDGVLDVVLPQEIVALCQQS
...| ..| .|...| || |||||  |.. ..|.| | .. 
taePevtshklrendkFLvlatDGLwdllsneevvslVgeh
subfamily_PPM1H_pd Subfamily PPM1H 329-377 2.6e-06 19.5 In-house 157-205 (404) alignment 
Range on Protein: 329-377
Range on HMM: 157-205/404.0
QHGLRAGTTATCAIVRDDALYLAQVGDSQALLYRDNELRPVTPSHRPED
.. .. | ||  |.| .. ||.|  |||.|.| | .|..|.   . || 
ayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet