Gene PPM1A-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP128_AA protein Get Run
MbreP128_AA_19-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 30-302 2.8e-104 341.4 In-house 4-281 (282) alignment 
Range on Protein: 30-302
Range on HMM: 4-281/282.0
SMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYE-----LLPVKDSLHAISDAMHRAFLRHD---R
........ ..|...|||||..|||||... .|..|..|||..|.|||||.|||.|...|||...| |         ... .....|....||..|   |
ksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeair

ALFADNKVRlDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPQLGALE
.|..|.| . |.|| |...||||..|.|..||||||..|||.|| ||.|.||||. |.|..||..|||.|...||.| ||.|||.||..||......| |
elstdlkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaee

QKVVADPDVTLVERDLEHDdFLLLCCDGIFDVMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLELGSRDNMSACLVVFN
|.|.|.|.|| .||. |.| ||.|.||||.||.|.......|...|... |....|..||....|| |||||.|...|.|.
qlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlfa
0034914 PP2C-like 20-302 4.2e-77 251.7 In-house 3-291 (295) alignment 
Range on Protein: 20-302
Range on HMM: 3-291/295.0
FLPSPKTDITSMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPG-LPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLP----VKDSLHAISDAMHR
.|. |.......       ..| | .||.| ..|||... ..|.  |...... | ||| | ..|..  ..|.  .| .|        .||. | .|...
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

AFLRHDRALFADNKV--RLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYK
|||. |..|.. .    .|..|| |.. .|. ...... |.|||| .|.|.|.| . |.||||  . || ||..|||.|..||| |.||..||.||||.|
aflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlk

RNPQLGALEQKVVADPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRrSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
....| .||. |.| |||| .|..||.||||||..||..||.|| .....|.. |. . .........|....|. |||||.....| .|
lllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrln
subfamily_PPM1G2_pd Subfamily PPM1G2 32-302 6e-73 238.3 In-house 13-287 (287) alignment 
Range on Protein: 32-302
Range on HMM: 13-287/287.0
DQRTADQKFGLAYMQGWRAHMEDAHITQPELPG---LPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYellpvKDSLH--AISDAMHRAFLRHDRALFAD
  . |  |.| . |||.| .||||||...||      .  ....| ||| ||.||.|.  .|   . .     |.|..  |.. ... |||. |. |  |
scanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkd

NKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPQLGALEQKVVA
.|.. ...| |...||.. .. .  | ||||..|.  |..   ..||||   .|..|| .|||||  .|| | ||.|||.||| .|.| .... || | |
eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivta

DPDVTLVERDlEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLELGSR------DNMSACLVVFN
 |||.. ..| |.|.||.| ||||.||..|.. ...| ..|..   ....... ||..||   |.      |||....||..
vPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvll
PP2Cc_SM00332 38-299 3.9e-70 229.4 In-house 10-274 (274) alignment 
Range on Protein: 38-299
Range on HMM: 10-274/274.0
QKFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDS-LHAISDAMHRAFLRHDRALFADNKVRLD---N
  .|.. |||||  |||||.....|    .|.|..| |||.|.||| .  ..|   .  ||  .||   ... .|...|||. | .. ..... ..   .
lsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenal

SGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPqlGALEQKVVADPDVTLV
|| |....|..  . .. |.||||  |||.||    ..||||  ..|| ||..|||.|..|||.||||.||||||...|.|   .  |. ..|.|||. |
sGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvv

ERdLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRR-SPDNPKAVCQALLKRCLEL-GSRDNMSACLV
.   ..|.||.|..||..||.|| .....|  .|.. .  .|..... | . ...  ||.||.....|
tl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 41-294 1.3e-64 211.2 Pfam-A 4-255 (255) alignment 
Range on Protein: 41-294
Range on HMM: 4-255/255.0
GLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR-HDRALFADNKV-RLDNSG
|   .||.| .||||||  ..|    |   ..|. | |||.| |.|.| . ||    .... . ...|   ..|. ..||.  |  |  ...    ..||
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflelekvekalrksfladtdeelksskantepsksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPqlgalEQKVVADPDVTLV
 |....|..... .. |.|||| .|||... . . |.||||  ..|| ||..|||.|. |||| | || |||.|||..|...     || |.|.|||| |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

ERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPdNPKAVCQALLKRCLELGSRDNM
... | |.||.|..||..||.|. .|. .|  .|     .|. ....|.. ... ||.||.
kltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 41-294 1.3e-64 211.2 In-house 4-255 (255) alignment 
Range on Protein: 41-294
Range on HMM: 4-255/255.0
GLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR-HDRALFADNKV-RLDNSG
|   .||.| .||||||  ..|    |   ..|. | |||.| |.|.| . ||    .... . ...|   ..|. ..||.  |  |  ...    ..||
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflelekvekalrksfladtdeelksskantepsksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPqlgalEQKVVADPDVTLV
 |....|..... .. |.|||| .|||... . . |.||||  ..|| ||..|||.|. |||| | || |||.|||..|...     || |.|.|||| |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

ERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPdNPKAVCQALLKRCLELGSRDNM
... | |.||.|..||..||.|. .|. .|  .|     .|. ....|.. ... ||.||.
kltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PPM_PTC7 40-294 4.7e-63 206.0 In-house 3-259 (259) alignment 
Range on Protein: 40-294
Range on HMM: 3-259/259.0
FGLAYMQGWRAHMEDAHITQPELP---GLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR--HDRALFA--DNKvRLD
.|   .||.| .||||||  . |    |   ..|..| |||.| |.|.| . ||     ... . ...|   ..|.  .||.   |  |    .|.   .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle..eilkerksfeeleklekalrksflaldtdeelksseant.eps

NSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI---NGRVDGGLAISRAFGDFDYKRNPQlgaLEQKVVADP
.|| |....|..... .. |.|||| .|||.|. . . |.|||| ...|| ||..|||.|.   |||| | || |||||||..|...     ||.|.|.|
tsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaeP

DVTLVERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpdNPKAVCQALLKRCLELGSRDNM
|.. ...| | |.||.|..||..||.|. .|. .| . |      |  ....|.. ... ||.||.
disstkidee.defliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
0049733 PP2C-like 39-302 4.5e-56 182.7 In-house 4-234 (235) alignment 
Range on Protein: 39-302
Range on HMM: 4-234/235.0
KFGLAYMQGW-RAHMEDAHITqpelpglpGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPvkDSLHAISDAMHRAFLRHDRALFADNKVR--LDNSG
..| | ..|. | ..|||..         |.... | ||| |......  ..|.  .| .||.   .|. . .|...|||. ..||.. .. .  |. .|
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspelagmg

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVingRVDGGLAISRAFGDFDYKrnpqlgaleqkvvadpdVTLVER
 |.. .|. . .....|.|||| .|.|.||| . |.||.|  ..|| ||..|||.|   || |.||..||.||...|                 . ... 
tTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.................pdvtvl

DLEHDDFLLLCCDGIFDVMSNATAIKFVATklrrspDNPKAVCQALLKRCLELGSRDNMSACLVVFN
.||..|||||..||..||.|. ........      .........|....|. |.|||... .| ..
elepgdflllasDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G_pd Subfamily PPM1G 132-301 1.1e-43 142.9 In-house 294-470 (473) alignment 
Range on Protein: 132-301
Range on HMM: 294-470/473.0
DNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPQLGALEQKVVADPDV
 .|| | . .|.   . |  | ||||. |.| ||      ||||. ..|..||..||| |  .|||.||| .|||.||. ||.| .|.. || . | ||.
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDi

TLVErDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDN-PKAVCQALLKRCLELGS------RDNMSACLVVF
   .   |.|.|| | ||||..||.    . || .||. . ..  ......||  ||           |||.. .|..
kvlt.lteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_PPM1E_pd Subfamily PPM1E 42-302 1.6e-43 141.8 In-house 8-263 (265) alignment 
Range on Protein: 42-302
Range on HMM: 8-263/265.0
LAYMQGWRAHMEDAHITQPELPGLPG------WSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDSLhaisDAMHRAFLRHDRALFADNKVRLDNSG
.| ... | .||| |.. ..|  | .       .|..| |||.| | |.|.  ||   .  .    .|..    .|...|| . |... .  .    .||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflqkaereklksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVIN---GRVDGGLAISRAFGDFDYKrnpqlgaleQKVVADPDVTL
 |  .||..  .     ||||..||.| |.    .. |||  ..|. || .|||.|..    ||.| |..||| || ..|         . |....||. 
stavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvae

VERDlEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
|| | .....|.| |||..||. . ...| |   |... .. . | . |..   | ||.||... .|...
veld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 39-301 5.6e-42 136.8 In-house 7-253 (255) alignment 
Range on Protein: 39-301
Range on HMM: 7-253/255.0
KFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLlASVLYELLPVKDSlhAISDAMHRAFLRHDRALfadnKVRLDNSGGTC
| | . | | |. |||  .   .  . ..  .|.. |||.| . |... ..|   .| ||| ....  .  .....|.   .  .    . |    | | 
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseel.ykilaelldlnna..nPvkslkkaykeistqi....serpkfiGtta

TSVLVSPTHYIFVNLGDSRSLLC-RGGKLAFQTRDHKPILPQERTRIRNAGGFVING----RVDGGLAISRAFGDFdYkrnpqlgaLEQKVVADPDVTLV
.|||.   ...  |.|||| .|| . |     . ||||  ..|. ||...||.|...    ||.| ||.|||.||  .        ||  ||.|||..  
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfvvpdPdlsqs

ERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKlrrspDNPKAVCQALLKRCLELGSRDNMSACLVVF
 .  ..| ||.| ||||.|..|.  |.. ||.       .|.  .. |     . || ||.| ... .
leiskkdkflilacdGiwdlisdeeaveivagi.....sdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 44-303 5e-39 127.2 In-house 11-268 (269) alignment 
Range on Protein: 44-303
Range on HMM: 11-268/269.0
YMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPV---KDSLH--AISDAMHRAFLRHDRALFADNKVRLDNSGGTC
 ..| | .|||  . . ..    | ||..| ||| |   |....| |  ... .|. .   |.     . |  .    |  |. |    |.  | .| |.
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtta

TSVLVSPTHYIFVNLGDSRSLLCRG-GKLAFQTRDHKPILPQERTRIRNAGGFV-ING--RVDGGLAISRAFGDFDYKRNpqlgaleQKVVADPDVTLVE
   ||. .. |  |.|||| .|.   ||    . ||||  ..|| ||..||||. ..|  || | ||.|||.||.  | .       . |.||||.   .
lialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadpdiltfd

RDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLrrspDNPKAVCQALLKRCLELGSRDNMSACLVVFNK
 |  . .||.| .||..| .||  |..|.  .|    ..|.   ..|  ..   || ||..  .|....
lddhkpeflilasdGlwdtfsneeavrfikerl....kepdfGakslvlesfkrGsvdnitvlvvklkn
subfamily_PPM1K_pd Subfamily PPM1K 40-302 1e-36 119.4 In-house 6-259 (263) alignment 
Range on Protein: 40-302
Range on HMM: 6-259/263.0
FGLAYMQGWRAHMEDAhITQPELPglPGWSFYSVIDGHAGAEVAHYSEDHLlASVLYELLPVKDSLHAIS----DAMHRAFLRHDRALFADNkvRLDNSG
 | . ..| ||  ||  |.  ||   |   ...| |||||.  |..  |.|   .| .||.  . |. .     . ..... |. . ..|..   | .||
vGkdsliGkraenedr.iklkeld..pellyvavfdGhaGsaaadfvhdkl.ekilkrllekekdleivlknafeeldkklkrylefsvaea..ellssG

GTCTSVLV-SPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVIN-----GRVDGGLAISRAFGDFDYKRNpqlGaleqkVVADPD
 | | .|.   |. .  .|||||..||| ||    ||||.| | .|. ||..|||.|        .|.| ||..|..||.| ||    |     |.|.|.
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry...G.....viatPe

VTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVatklrRSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
  ... | ..| ||.|. ||| .|...    ..|     |   .|.   .|| .  |. || || .| .| ..
tkslkvdhaadsflvlitdgisfvvnsqelcdlv.....rlchdpeeaahalteqalqygsednatavvvplg
subfamily_ILKAP_pd Subfamily ILKAP 43-270 1.7e-34 112.3 In-house 10-246 (293) alignment 
Range on Protein: 43-270
Range on HMM: 10-246/293.0
AYMQGWRAHMEDAHITQPELP--------GLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYElLPVKDSLH---AISDAMHRAFLRHDRALFAD--NKV
|  .| |..|.|||. . .|          .   |.|.| |||||   .... ..|  ..| . || .|       |  ..  .| . |. ...   .. 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek.lpksdvsakekeikkclvdsfkktdeefLklaskak

RLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA------FQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRnpqLGaleqk
     | | |.|||        |||||...|.|  . .        |.||.|.  .|| ||. |||.| .||| | | .||. ||  .||   ||     
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....

VVADPDVTLVERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRS
|.. |||. .| .   | |..|.|||...|.|.  ..||.   |   
vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvlede
PPM_PTC7_SpoIIE 40-293 9e-32 103.7 In-house 3-229 (230) alignment 
Range on Protein: 40-293
Range on HMM: 3-229/230.0
FGLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEvaHYSEDHLL---ASVLYELLP-VKDSLHAISDAMHRAFLRHdralfadnkvrLD
.|   .||.| .||||||  . .   .|   . .. . ||| | .  ..   .|    ..  .. |. ... |... .|.....               .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede...........ps

NSGGTCTSVLVSPTH--YIFVNLGDSRSLLCRG-GKlafqtrdhkpilpqERTRIrNAGGFV-I---NGRVDGGLAISRAFGDFDYKRnpqlgaLEQKVV
.|| |.. .|. |..    ..|.|||. ||.|. |.              ||.||  |||.. .   .||| | ||.|.|.||. ..        .. | 
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvve

ADPDvTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpdnpkaVCQALLKRCLELGSRDN
| || |  ... ..|.|| |..||..||.|.. .. .|   | .       ....||. .. |.. ..
aepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDitllvvrv
subfamily_PPM1G_pd Subfamily PPM1G 21-128 2.3e-19 62.8 In-house 2-104 (473) alignment 
Range on Protein: 21-128
Range on HMM: 2-104/473.0
LPSPKTDITSMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPGlpGWSFYSVIDGHAGAEVAHYSEDHLLaSVLYELLPVKDSlhAISDAMHRAFLRHD
|  ||.. .| |. . . ..| . |||||. .|||| . ..|     .|...| ||| |.|||.|  ..|.  .| .    |.    .. |.. |||  |
lskpkvekesedesneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklp.dllkaqkgykeg..dvekaleeaflalD

RALFADNK
. | |.. 
eklkaees
subfamily_PPM1D_pd Subfamily PPM1D 45-193 2.8e-18 59.1 In-house 9-173 (309) alignment 
Range on Protein: 45-193
Range on HMM: 9-173/309.0
MQGWRAHMEDAHITQ--PELPGL-PGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDSLHAISDAMHRAFLRHDRAL------FADNKVRLD-NS
 || | .|||    .  .|  ..  ...| .|.||| | | |..  .||.  .  .   . .. ... .|...|||   .|.      .. .|  |   .
dqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllsta

GGTCTSVLVSPTHYIFVNLGDSRSLLCRGGK------LAFQTRDHKPILPQERTRIRNAGGFVIN
| |.. |..  ..    . |||. .|    .          |.||||  |.|..||...|| | .
GttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_KAPP-like_pd Subfamily KAPP-like 68-298 4.1e-18 58.4 In-house 34-263 (266) alignment 
Range on Protein: 68-298
Range on HMM: 34-263/266.0
WSFYSVIDGHAGAEVAHySEDHLLASVLYELLPVKDSLHAISDAMHRAFLRHDRALFADNKV-RLDNSGGTCTSVLVSP---THYIF-VNLGDSRSLLCR
 ....|.|||||  .|  . ..|.  .| .||   .  .   .  ..  | ..     |.|.   .  | | | .||      .|.   |.||| ..|.|
ialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaflsr

GGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVD-GGLAISRAFGDFDYKRnPQLGALEQKVVADPdVTLVerdlEHDDFLLLCCDGIFDVMSNATAIK
| .  . . |||   |.|. ||.. |  . ...    |||.|||.||   |.  ..|   .  |... ..|      .|.||..  ||..||.|   ||.
GneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfike.lniGlisepyvsnr.illt....pfdkflivasdGlwdvisGkdaie

FVATKLRRSpDNPKAVCQALLKRCLE-LGSRDNMSACL
 | .   .  .  . ....||.  ..   ..||.|  .
kvkslydqq.atedkmasslletaiqsikakdnvsviv
subfamily_PP2D1_pd Subfamily PP2D1 144-268 9.4e-17 53.9 In-house 187-307 (492) alignment 
Range on Protein: 144-268
Range on HMM: 187-307/492.0
SPTHYIfVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVI----NGRVDGGLAISRAFGDFDykrNPQlgaLEQKVVADPDVTLVERDlEH
. . ||  | |. . .|||.||    ||.| |  ..||||...||. |     ||.|.| |   |  | .    .|.   |.. |. .| .| |. | |.
lgvlyi.anaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpk...LkksvipePkttsvkld.ea

DDFLLLCCDGIFDVMSNATAIKFVATKLR
. ||.|   |...|.|.   .. | . |.
aqflvlAsnGlWevlseeevlsLvkqtla
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 70-211 1.6e-16 53.7 In-house 22-185 (292) alignment 
Range on Protein: 70-211
Range on HMM: 22-185/292.0
F-YSVIDGHA--GAEVAHYSEDHLLAsvlyELLPVKDSLHAISDAMHRAFLrHDRALFADNKVRLDNSGGTCTSVLVSPTH--YIFVNLGDSRSLLCR--
|  .|.|||   | .|| ..||.|      ||| .   | ..|.|.    |    | . .  .   .|..|..   . .     |  |.||||.|| |  
flaavldGhGvnGdkvaqlaedtlev....elleltrqlqelsealllril.diaakldkltidaresattavvcarvrddralilanvGdsrallgrcl

GG---KLAFQTRDHKPILPQERTRIRNAGGFVI-----------NGRV------DGGLAISRAFGDFDY
||   .|   .|||||  |.|| ||..|||.|              ||      .|.||.||| |||  
ggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 70-298 7.8e-16 50.7 In-house 35-273 (276) alignment 
Range on Protein: 70-298
Range on HMM: 35-273/276.0
FYSVIDGHAGAEVAHySEDHLLASVLYELLPV-KDSLHAISDAMHRAFLR----HDRALFADNKVR-LDNSGGTCTSVLVSPTH---------YIF-VNL
...|.|||||  .|  . ..|.  .|  ||   . ||    |  .  . .     |     |.|..  .  | | | .||             |.   |.
lfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvanv

GDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVD-GGLAISRAFGDFDYKRnPQLGALEQKVVADPdVTLVerdlEHDDFLLLCCDGIFD
||| ..|.|| .  . . |||   |.|. ||.. |  . ...    |||.|||.||   |.  ..|   .  |... ..|      .|.||..  ||..|
GdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfike.lniGlisepyvsnr.illt....pfdkflivasdGlwd

VMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLE-LGSRDNMSACL
|.|   ||. | .   .  .  . ....||.  ..   ..||.|  .
visGkdaiekvkslydqq.atedkmasslletaiqsikakdnvsviv
subfamily_PDP_pd Subfamily PDP 124-271 2.2e-14 46.4 In-house 142-316 (398) alignment 
Range on Protein: 124-271
Range on HMM: 142-316/398.0
FADNKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA---F--QTRDHKPILPQERTRIRNAG------GFVINGRVDGGLAISRAFGDFDYK
  .....   || ... .|...|.    | ||.|..|..  . .       ..|.    ..| .||...         . |||. | |. .|||||. ||
slreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK

RNPQLGA--LEQ---------------KVVADPDVTLVErDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSP
 . .|    ||.                . |.|.||  .   |.| ||.|  ||..|..|| .... |   | .. 
wseelqkkvlekaylkvlepkdyktPPYltaePevtshk.lrendkFLvlatDGLwdllsneevvslVgehlakkk
PP2C_SIG_SM00331 89-298 3.3e-12 39.4 In-house 54-214 (217) alignment 
Range on Protein: 89-298
Range on HMM: 54-214/217.0
HLLASVLYELLPVKDSLHAISDAMHRAflrhdralfadnkVRLDNSGGTCTSVLV--SPTHYIFVNLGDSRSLLCRGGKLAFQTRDhkpilpqertrirn
..|   | |   ... |... .|...                 .... |..  |.  |  .  ..|.|||| .| | ||| ... |              
talrellsegeelsqalkrlnraiyee.............keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............

aggfvingrvdgglaisrafgdfdyKRNPQLGALEQKVvadpdVTLVERDLEHDDFLLLCCDGIFDVMSNAT-AIKFVATKLRRSP----DNPKA-VCQA
                         .. ..||  ..       |.  |..|| .|.|||. ||.....| .. | . . . |. .     .  ..   . 
.........................vegaplGlepevs.....vdirelelekgdllllytDGltearsekgfaeerleeiledlvdseaqelaqkivee

LLKRCLELGSRDNMSACL
|| .  . . .|...  .
llelakgsngeDdiTvvv
PPM_PTC7_motif 244-294 5.8e-10 32.5 In-house 1-51 (51) alignment 
Range on Protein: 244-294
Range on HMM: 1-51/51.0
LLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNM
.|..||..||.|. .|. .|   |    . |  ... | ...|. || ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PPM1D_pd Subfamily PPM1D 200-301 8.4e-10 31.2 In-house 201-307 (309) alignment 
Range on Protein: 200-301
Range on HMM: 201-307/309.0
LAISRAFGDFdYKRNPQLGalEQKVVADPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRS---PDNPKAVCQALLKRCLELGSR-----
||..|. ||. .  | . |  |  |  .|||. ...| ....|..|  ||...|.. ..|...| ..   .    .. . | .||.|. |.  ..     
LavaRslGDl.Wsynaksg..efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMSACLVVF
||.|. .|..
Dnvsvivvil
PPM_PTC7_SpoIIE_motif 233-299 8e-09 29.1 In-house 5-78 (81) alignment 
Range on Protein: 233-299
Range on HMM: 5-78/81.0
VERDLEHDDFLLLCCDGIF-------DVMSNATAIKFVATKlrrSPDNPKAVCQALLKRCLELG---SRDNMSACLV
.| .|. .| |||..||..       ..... ........    .  ... ....|....||.|   ..|...  ..
aefqLkpgdvllLyTDGltEardsdgelfgkeellrladra...egkslqeladklvdevlengsgereDDitllvl
subfamily_PPM1H_pd Subfamily PPM1H 195-273 3.4e-07 22.4 In-house 276-358 (404) alignment 
Range on Protein: 195-273
Range on HMM: 276-358/404.0
RVDGGLAISRAFGDFDYKRNPQLGALEQKVVADPDVTL---VERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPD-N
|. . ....| .|| . |   .   .   . . |.|.     . . ..|| |.|  ||..||.|| .. . |.  | . .. .
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskveped
SpoIIE Stage II sporulation protein E (SpoIIE) 213-294 1.5e-06 20.2 Pfam-A 102-185 (193) alignment 
Range on Protein: 213-294
Range on HMM: 102-185/193.0
RNPQLGALEQkvvadPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAI----KFVATKLRRSPDNPKAVCQALLKRCLELG---SRDNM
... || |..      |.. .| .|| .| |||. ||... .. .. .    .. |.  ... ........||....||||    .| .
tglplGilpe.....adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDi
SpoIIE Stage II sporulation protein E (SpoIIE) 213-294 1.5e-06 20.2 In-house 102-185 (193) alignment 
Range on Protein: 213-294
Range on HMM: 102-185/193.0
RNPQLGALEQkvvadPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAI----KFVATKLRRSPDNPKAVCQALLKRCLELG---SRDNM
... || |..      |.. .| .|| .| |||. ||... .. .. .    .. |.  ... ........||....||||    .| .
tglplGilpe.....adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDi
subfamily_PPM1H_pd Subfamily PPM1H 109-186 8.1e-06 17.8 In-house 137-212 (404) alignment 
Range on Protein: 109-186
Range on HMM: 137-212/404.0
SDAMHRAFLRHDRALFADNKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPIlpQERTRIRN
  |.  |||. |  .  ...   .. | |  ..||        | ||||..|.| ...    .|. |    || |...
iGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPe..teRqRlqe
subfamily_PPTC7_pd Subfamily PPTC7 234-297 9.6e-06 18.2 In-house 161-224 (252) alignment 
Range on Protein: 234-297
Range on HMM: 161-224/252.0
ERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNMSAC
. .....| ..|  ||.|| ... . .....    ..... . ....| ..  ||.   .... 
sfavkkgDiivlatDGlfDNlledeileilkelkeseksslqslakklaekarelsldpeyesp