Gene PPM1A-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP129_AA protein Get Run
MbreP129_AA_15-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 20-290 2.6e-106 348.1 In-house 9-281 (282) alignment
Range on Protein: 20-290
Range on HMM: 9-281/282.0
PNGLSYALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAY---TKGDKSAANLEQVLSKGLFELDEAIKEKHPQ
 ||| |..|||||||..|||||.| |.|..|.....|||||||.|..|.... . ....|...|..   .. .... .....|..|...|||||.|.. .
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

LKAGhDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPDLKPEEQKVTA
||.  |.||||... .|.|......|.|||||||...||..|.|.|||||.. |..||..|||.. ..||.|.||||||.||||||.....|.|||.|.|
lkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

LSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILFP
 ...|||.|. .|.|||||||||||||..| |  .|.  ||.....|..|. |.|..|| ||.||.|.|..||.
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

subfamily_PPM1G2_pd Subfamily PPM1G2 5-288 1.8e-80 262.9 In-house 2-285 (287) alignment
Range on Protein: 5-288
Range on HMM: 2-285/287.0
LEKPVTEKHHDAATlPNGLSYALSSMQGWRIHMEDAHAVSADL---PNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTkgdksAANLEQVLSK
|..||..|......  .    . |.|||.|..||||| .  .|   .. .. |||||||||||..|.  ||. .|. |.. ....       .|||.| .
lsepvvakesasca.naltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.....egaleqilkd

GLFELDEAIKEKhPQLKAghDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEY
.. |.|| . ..  .||   . .||| .   ..|....  |.||||||| |.|.||  . ||||..| |..||..||||.|..||.||||.|||.||.|.
afletDeellkd.eklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfef

KDRPDLKPEEQKVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSK------DNMSALLIL
|.   .||||| |||. | .  .....|||||||||||||||||. |  .|.  | .| . ..|.. ||| ||   |.      |||..... 
kknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv

0034914 PP2C-like 16-291 1.3e-75 246.8 In-house 14-292 (295) alignment
Range on Protein: 16-291
Range on HMM: 14-292/295.0
AATLPNGLSYALSSMQGWRIHMEDAHAVSADLPN-LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYT--KGDKSAANLEQVLSKGLFELDEAIKE
  .|.. |... .|.||.| ..|||. |  .|.. |....||.||||||| ...  | |...... .    .    . |  ..|..| |.. ..||.. |
lsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeelle

KHPQlKAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPDLKPEEQ
.  . .  ...||.|... ..... ....|.|||||||...|.... | ||||..| | .||..|||.. .|||.|.|||.||.||...|  . | ..|.
lall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllsllllep

KVTALSDTTSISRT-PKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILFPG
 |.|  |.|....| ..|.||.||.||.||||.|| .  .|. .|..|.|.| .|. |.|..|. ||.||...... ..|
lvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng

PP2Cc_SM00332 19-287 2.4e-72 236.6 In-house 6-274 (274) alignment
Range on Protein: 19-287
Range on HMM: 6-274/274.0
LPNGLSYALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKsAANLEQVLSKGLFELDEAIKEKHPQLK
  .||||..|||||||  |||||.|  || .  ....|.|||||||. |.  . . . .|. ..  . |...   . |..|.|.. ..||.| |.  ...
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqske

AGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPdlKPEEQKVTALS
    .||||... ....  ....|.|||||||...||..  . ||||.|| |..|||.|||..| ||| |.||||||.||...|.    |..|. .||. 
lenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaep

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY--DAERIADLLLDYCLEL-GSKDNMSALLI
|.. .. |..||||.||.||.||||.|. |  .|. .|..|   |....|.|| .....  ||.||......
dvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

PP2C Protein phosphatase 2C 25-282 6.8e-70 228.5 Pfam-A 3-255 (255) alignment
Range on Protein: 25-282
Range on HMM: 3-255/255.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE-LDEAIKEkHPQLKaG
.  |..||.| .|||||.  ..|       . |.|||||||||  ... |.|   . . . .  ....    ..|..|.|.  . .|| .|  . . .  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks.skant.e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPdlkpeEQKVTALS
...|||| .. ..... . . |.|||||||..... | . | ||||||| |..||..|||... .|||.|.||||||.||.|.|. .     || |.|  
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaeP

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNM
|.||...|..||||.||.||.||||... .  .|. .|. .......|. |.|.... ||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 25-282 6.8e-70 228.5 In-house 3-255 (255) alignment
Range on Protein: 25-282
Range on HMM: 3-255/255.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE-LDEAIKEkHPQLKaG
.  |..||.| .|||||.  ..|       . |.|||||||||  ... |.|   . . . .  ....    ..|..|.|.  . .|| .|  . . .  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks.skant.e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPdlkpeEQKVTALS
...|||| .. ..... . . |.|||||||..... | . | ||||||| |..||..|||... .|||.|.||||||.||.|.|. .     || |.|  
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaeP

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNM
|.||...|..||||.||.||.||||... .  .|. .|. .......|. |.|.... ||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 25-282 5.7e-69 225.4 In-house 3-259 (259) alignment
Range on Protein: 25-282
Range on HMM: 3-259/259.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE--LDEAIKEkHPQLKa
.  |..||.| .|||||.. |.|       . |.||||||||| .... |.|.. ... . .  ....    .||..|.|.  .  .|| .|  . . . 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelks.seant.

GHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE---MGRVCGNLAVSRAIGDYEYKDRPDlkpEEQKVT
....|||| .. ..|.. .   |.|||||||...|... . | |||||.| | .||..|||...   .|||.|.||||||.||.|.|. .    |||.|.
epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvs

ALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGyDAERIADLLLDYCLELGSKDNM
|  |..|. ....||||.||.||.|||.... .  .|. .|. . |....|. |.|.... ||.||.
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

0049733 PP2C-like 23-289 5.6e-56 182.4 In-house 3-233 (235) alignment
Range on Protein: 23-289
Range on HMM: 3-233/235.0
LSYALSSMQGW-RIHMEDAHAVsadlpnlpNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYtkgdKSAANLEQVLSKGLFELDEAIKEKHPQLKaGH
||.. .|..|. | ..|||..|        ...||||.|||||  ..  | |...... .  .      .  .||..| | . ...||. |.  . . ..
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalasp.el

DRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIemgRVCGNLAVSRAIGDYEYKdrpdlkpeeqkvtalSDTT
...|.|... ....  ....|.|||||.|..|||. . | ||.|..| | |||..|||..   || | ||..||.||...|                |.|
agmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvt

SISRTPKDeFLVLACDGIWDVLTNEGVQLVVNFflergYDAERIADLLLDYCLELGSKDNMSALLILF
..  .| | ||.||.||.||||..| .. ...      .|.| .|. |....|. |..||...... .
vlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl

subfamily_PPM1E_pd Subfamily PPM1E 27-289 5.7e-47 153.1 In-house 8-262 (265) alignment
Range on Protein: 27-289
Range on HMM: 8-262/265.0
LSSMQGWRIHMEDAHAVSADLPN------LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKsaanleQVLSKGLFELDEAIKEKHPQlkaG
. .... | .||| | .  || .       .. | |||||||||   .. | .   . . . |  ..  .      . | ... ..||.. .|  .    
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa......ealkeafkltDerflqkaer...e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFI---EMGRVCGNLAVSRAIGDYEYKdrpdlkpeeQKVTAL
. .|||| .. ....  . .   |||.|.||..|..   .. |||..| | .||..|||..   .. || |.|.|||||||...|         . |.. 
klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsge

SDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY-DAERIADLLLDYCLELGSKDNMSALLILF
.|..... . ..|.|.|||||.|||...| |  .|. ||..|  | ...| ||..   | ||.||........
advaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

subfamily_PPM1G_pd Subfamily PPM1G 118-276 4.2e-46 150.9 In-house 291-451 (473) alignment
Range on Protein: 118-276
Range on HMM: 291-451/473.0
KAGHDrSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPDLKPEEQKVTA
. |.| ||.| .   . | ...  | ||||.|| ..||      |||| || |..||..||| ..  ||| | | .|||.||. ||   .|...|| ..|
epGed.sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

LSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY--DAERIADLLLDYCLEL
| |      |..||||||||||||.|.. . |   |.  |. |     ..| . ||| ||  
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclap

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 26-289 5.9e-42 136.7 In-house 9-253 (255) alignment
Range on Protein: 26-289
Range on HMM: 9-253/255.0
ALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEaytkgDKSAANLEQVLSKGLFELDEAIKEKHpqlkaghDRSG
. | | | |  |||  ..     . ..  ..|.||||||.. .. | | . . ...       |   || ...| |   |..  |.|.         . |
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaell.....dlnnanPvkslkkaykeistqiserp.......kfiG

STVICGFVTETSVVLCNCGDSRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMG----RVCGNLAVSRAIGDYeYKdRPDLKPEEQkvtaLSDt
.| .  ...|  |...| ||||.||   ||  |  . |||||.| |..||...||..  .    || |.||||||.||  .   | . |. .    ||. 
ttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fl.ePfvvpdPd....lsq.

tSISRTPKDEFLVLACDGIWDVLTNEG-VQLVVNFflergYDAERIADLLLDYCLELGSKDNMSALLILF
 |.  . ||.||.||||||||....|  |..|..       |.|. |  | |.  . ||.||.| ..| .
.sleiskkdkflilacdGiwdlisdeeaveivagi.....sdpekaaeklrdlayssGstdnisvivikl

subfamily_PPM1L_pd Subfamily PPM1L 26-289 2.6e-41 134.6 In-house 8-266 (269) alignment
Range on Protein: 26-289
Range on HMM: 8-266/269.0
ALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTE---AYTKGDKSAANLEQVLSKGLFELDEAIKEkhpQLKAGHD
|  |..| | .|||   .  |. |  .  .|||||||||.. .  | ... .|| .     .  | ..   | ...| . .. .|| . |   ..|. .|
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklle...kakraed

RSGSTVICGFVTETSVVLCNCGDSRAVLVS-DGKVKFATSDHKPSDEIETQRIKNAGGFIEM---GRVCGNLAVSRAIGDYEYKDRpdlkpeeQKVTALS
 .|.|..  .|.|. ... | |||| ||.  .||    . |||| .  | .|||.||||| .    || | ||.|||.|||  ||.       . | |  
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadp

DTTSIS-RTPKDEFLVLACDGIWDVLTNEGvqlVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILF
|  ..     | |||.||.||.|| ..||     |.| .||  . .  |  |   .   || ||.. |.. .
diltfdlddhkpeflilasdGlwdtfsnee...avrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl

PPM_PTC7_SpoIIE 25-281 7.4e-37 120.4 In-house 3-229 (230) alignment
Range on Protein: 25-281
Range on HMM: 3-229/230.0
YALSSMQGWRIHMEDAHAVSADL---PNLPNGALFAVFDGHGGKTvsTTAGEIFIQAITSTEaYTKGDksaaNLEQVLSKGLFELDEAIKEKhpqlkagH
.  |..||.| .|||||.. |..   .    .......|||||    . | . . .|. .   .. ..    ..|..|...  .|. .....       .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle....kpeeilrrlnlalaadlede.......p

DRSGSTVICGFVTETS--VVLCNCGDSRAVLVSD-GKvkfatsdhkpsdeiETQRIkNAGGFIE----MGRVCGNLAVSRAIGDYEYKDrpdlkpEEQKV
. ||.|.... .. ..  . ..|.|||...||.| |.              |  ||  |||...     ||| |.||||.|.||. ...      ... |
sssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvv

TALSDtTSISRT-PKDEFLVLACDGIWDVLTN-EGVQLVVNFFLERgydaerIADLLLDYCLELGSKDN
.|  | ||  ..  |||||.||.||.||||.. | |.||.. ...       .|. ||.... |.. ..
eaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDitllvvrv

subfamily_ILKAP_pd Subfamily ILKAP 29-264 4.9e-33 107.5 In-house 11-251 (293) alignment
Range on Protein: 29-264
Range on HMM: 11-251/293.0
SMQGWRIHMEDAHAVSADLP---N-----LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTeaYTKGDKSA--ANLEQVLSKGLFELDEAIKEKHPQLK
  .| | .|.||| .  ||    .     . . . .||||||.|.  |  | | . . | ..  ..|.| ||   .. . | .   . ||   ..  . |
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktdeefLklaskak

aGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGK---VKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKdrpdlkpeEQ
    . |||... .| .  .   | |||.||||    .|.   .   | ||.| .. | .||. |||... ||| | | |||.||| ..|        . 
.PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk........rl

KVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAER
 |..  |.. .  |. | |.||||||.|.|.... |   ..  ||  .| ..
GvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrk

subfamily_PPM1K_pd Subfamily PPM1K 28-289 7.2e-33 106.8 In-house 9-258 (263) alignment
Range on Protein: 28-289
Range on HMM: 9-258/263.0
SSMQGWRIHMEDAHAVSADLPNLpngALFAVFDGHGGKTVSTTAGEIFIQAITSteaYTkgdKSAANLEQVLSKGLFELDEAIKEKHPQL--KAGHDRSG
 |..| |   ||   .    |.|     .||||||.| .    . . . . ..    .    .   .||.|| . . |||...|     .  .| .  ||
dsliGkraenedriklkeldpel...lyvavfdGhaGsaaadfvhdklekilkr...ll...ekekdleivlknafeeldkklkrylefsvaeaellssG

STVICGFVTE-TSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEM-----GRVCGNLAVSRAIGDYEYKdrpdlkPeeQKVTALSD
.|    .. . | .|| . |||||.|  .|| |  |.||.|. | | .|||.|||..|.      .| | ||..|..|| . |      .    | |  .
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk......r..yGviatPe

TTSISR-TPKDEFLVLACDGIWDVLTNEGVQlvvnFFLERGYDAERIADLLLDYCLELGSKDNMSALLILF
| |.     .| ||||  ||| .|.... .     ....   | |. |. | .  |. ||.|| .|... .
tkslkvdhaadsflvlitdgisfvvnsqelc....dlvrlchdpeeaahalteqalqygsednatavvvpl

subfamily_KAPP-like_pd Subfamily KAPP-like 45-286 3.3e-29 94.7 In-house 26-263 (266) alignment
Range on Protein: 45-286
Range on HMM: 26-263/266.0
ADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVlSKgLfeLDEAIKEKHPQLKAgHDRSGSTVICGFVTE----TSVVL
 .| |  | ||||||||| || .. .| ..| . .      || |.   |  .  || |  |..|.||   .||  ..  |.|    .| .      .  
kklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydq.sk.l..lenafkevdaklkd.feyeGatatlalvwsdGqqrylqv

CNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVC-GNLAVSRAIGDYEYKDRPDLKPEEQKVtalSDttSISRTPKDEFLVLACDGI
.| ||| | |    .  . . |||  |. | ||||. |  .  ..     ||||||.||.  |..      |  |   |.   |. ||.|.||..| ||.
anvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyv...sn..rilltpfdkflivasdGl

WDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLE-LGSKDNMSALL
|||.. .    .|. . ...  ....|. ||.  ..   .|||.| ..
wdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 45-286 4.2e-26 84.4 In-house 25-273 (276) alignment
Range on Protein: 45-286
Range on HMM: 25-273/276.0
ADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITS-----TEAYTKGDKSAANLEQvlSKGLFelDEAIKEKHPQLKAgHDRSGSTVICGFVTETS--
 || |  | ||||||||| || .. .| ..| . .         . || |.   |  .   ..|.   ...||   .||  ..  |.|    .| .    
kdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniyd..qskll..ldlfkevdaklkd.feyeGatatlalvwsdGee

--------VVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVC-GNLAVSRAIGDYEYKDRPDLKPEEQKVtalSDttSISRTPK
        .  .| ||| | |    .  . . ||| .|  | ||||. |  .  ..     ||||||.||.  |..      |  |   |.   |. ||.
qqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyv...sn..rilltpf

DEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLE-LGSKDNMSALL
|.||..| ||.|||.. .    .|. . ...  ....|. ||.  ..   .|||.| ..
dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv

subfamily_PPM1D_pd Subfamily PPM1D 28-183 2.5e-21 69.1 In-house 7-173 (309) alignment
Range on Protein: 28-183
Range on HMM: 7-173/309.0
SSMQGWRIHMEDAHAVSADLPNLP---NGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKgdKSAANLEQVLSKGLFELDEAIKEK---HPQLKAGH
.. || | .|||  |.. .  .     . | .|||||||||  .. | |  .. |.  . ..   .. ... . .... ... ||.|.|    |. | |.
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkfls..sepedvleAireaflatheamkkkleeWpktksgl

D-RSGSTVICGFVTETSVVLCNCGDSRAVLVSDGK------VKFATSDHKPSDEIETQRIKNAGGFIEM
   .|.|. . ..... . . . |||..|| .. .       |  |.||||..  |..||...|| . .
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa

subfamily_PPM1G_pd Subfamily PPM1G 4-113 1.4e-20 66.8 In-house 1-102 (473) alignment
Range on Protein: 4-113
Range on HMM: 1-102/473.0
FLEKPVTEKHHDAAtLPNGLSYALSSMQGWRIHMEDAHAVSADLPNlpNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaanLEQVLSKGL
.|.|| .||...     ..|||. |.|||||  .|||| .  || .  . .||||.|||||| |..   . . . .. ...| .||     .|. |..  
ylskpkvekesede.sneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgykegd.....vekaleeaf

FELDEAIKEK
..||| .|..
lalDeklkae

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 55-188 3.2e-19 62.6 In-house 23-155 (292) alignment
Range on Protein: 55-188
Range on HMM: 23-155/292.0
LFAVFDGHG--GKTVSTTAGEIFIQAITSTEAYtKGDKSAANLEQVLSKGlfeldeaIKEKHPQLKAGhDRSGSTVICGFVTET-SVVLCNCGDSRAVLV
| ||.||||  |. |.  | . . . ....    . . | | | ..|. .        | ..  ..|.  .....|.|  | .  ...| | |||||.| 
laavldGhGvnGdkvaqlaedtlevelleltrq.lqelsealllrildia.......akldkltidar.esattavvcarvrddralilanvGdsrallg

S-----DGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCG
      | ...  . ||||.|  | .||..|||..|  || |
rclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg

subfamily_PDP_pd Subfamily PDP 95-259 1.4e-18 60.1 In-house 115-315 (398) alignment
Range on Protein: 95-259
Range on HMM: 115-315/398.0
LEQVLSKGLFELDEAI-KEKHPQL-------KAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGKVKFA--TSDHKPSDEIETQRIKNAG---
....|.|.  .||. | .|  ..|       ..    ||.. .. .. .|.. . | ||.|||| .   .|...    ..|.  . | | .|||..    
vkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPge

---GFIEMGRVCGNLAVSRAIGDYEYKDRPDLKP---EE------Q--------KVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLER
     |  ||. |.|. .|| ||..||   .|.    |.      .         .||  . ||   ...| ||||| ||.||.|.|| |  .|. .|..
esktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlak

G
 
k

subfamily_PP2D1_pd Subfamily PP2D1 118-256 4.6e-18 58.2 In-house 170-306 (492) alignment
Range on Protein: 118-256
Range on HMM: 170-306/492.0
KAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIE----MGRVCGNLAVSRAIGDYEykdRPDLKpeeQK
. | ... ..     .  . . . | |. .|||. .|| .  | .| | .. | .|...||. .     .|.| | | . | .| |     |.||   . 
eeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpkLk...ks

VTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFL
|     |||.  . .. |||||  |.|.||..| |  .|. .|
vipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl

PP2C_SIG_SM00331 50-286 3.4e-15 49.2 In-house 26-214 (217) alignment
Range on Protein: 50-286
Range on HMM: 26-214/217.0
LPNG-ALFAVFDGHGgktVSTTAGEIFIQAITSTEAYTKGDksaanleQVLSKGLFELDEAIKEKhpqlkAGHDRSGSTVICGFV--TETSVVLCNCGDS
|..|  |..|.||.|       |...  |. |  . . . .       . ||. | .|..||.|.     .. .... |.... .  ..  . ..|.|||
lnegrlllvvaDgmG...kGlaAaaassqlrtalrellseg.......eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGds

RAVLVSDGKVKFATSDhkpsdeietqriknaggfiemgrvcgnlavsraigdyeY-----------KdrpdlkpeeqkvtalSDTTSISRTPkDEFLVLA
| .|. ||| .. ..|                                                  .                |.....  . ...|.|.
rpyllrdgklveilkd......................................vegaplGlepevs...............vdirelelek.gdlllly

CDGIWDVL-----TNEGVQLVVNFFLerGYDAERIAD----LLLDYCLELGSKDNMSALL
 ||....       .| .....  ..  .  |...|.     || .  . . .|... ..
tDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvv

PPM_PTC7_motif 233-282 7.2e-13 41.8 In-house 1-51 (51) alignment
Range on Protein: 233-282
Range on HMM: 1-51/51.0
VLACDGIWDVLTNEGVQLVVNFFLERGY-DAERIADLLLDYCLELGSKDNM
.||.||.||||... .  .|. .|.  . . ...|  | |..|. ||.||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

PP2C_2 Protein phosphatase 2C 49-246 7.9e-12 37.9 Pfam-A 20-184 (212) alignment
Range on Protein: 49-246
Range on HMM: 20-184/212.0
NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVLSKGLFELDEAIK---EKHPQlKAGHDRSGSTVICGFVTETSVVLCNCGD
.  .| |.|| ||.|    |  . ... .|.... . .  ..|... |..| . . |.....|   |.. | ..  .  ..|... ..|.. .|....||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGD

SRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMgrvcgnlavsraigdyeykdrpdlkpeeqkvtalsdTTSISRTPKDEFLVLACDGIWDVLT
...|.. .||.|. ......   . ||.... .  . |.                                     ... .... . |.|  ||..| |.
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel....................................rirrlklepgdalllmTDGvsdslr

NE
.|
ke

PP2C_2 Protein phosphatase 2C 49-246 7.9e-12 37.9 In-house 20-184 (212) alignment
Range on Protein: 49-246
Range on HMM: 20-184/212.0
NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVLSKGLFELDEAIK---EKHPQlKAGHDRSGSTVICGFVTETSVVLCNCGD
.  .| |.|| ||.|    |  . ... .|.... . .  ..|... |..| . . |.....|   |.. | ..  .  ..|... ..|.. .|....||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGD

SRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMgrvcgnlavsraigdyeykdrpdlkpeeqkvtalsdTTSISRTPKDEFLVLACDGIWDVLT
...|.. .||.|. ......   . ||.... .  . |.                                     ... .... . |.|  ||..| |.
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel....................................rirrlklepgdalllmTDGvsdslr

NE
.|
ke

subfamily_TAB1_pd Subfamily TAB1 121-203 3.3e-10 32.3 In-house 126-218 (333) alignment
Range on Protein: 121-203
Range on HMM: 126-218/333.0
HDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGKVKFATSDHKPSDEIETQRIKNAGGF---IEMGRVCGNLAVSRAIGDYEYK----D
. . |.| .   .    .   |.|||||.||      |||   .||.   | | .|.|. |     |.  .. |.    |.||||. |    |
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykd

subfamily_PPM1H_pd Subfamily PPM1H 185-258 4.2e-09 28.6 In-house 276-353 (404) alignment
Range on Protein: 185-258
Range on HMM: 276-353/404.0
RVCGNLAVSRAIGDYEYKDR---PDLKPEEQKVTAL--SDTTSISrTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLER
|. . ..|.| .||.| |       .||    |  .   | |... . .|. |.|| ||.||||.|| |  .|. .|..
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqve.sleDdvlilatDGLWdvlsneevaeivrevlsk

subfamily_PHLPP_pd Subfamily PHLPP 134-287 1.2e-08 27.2 In-house 96-243 (246) alignment
Range on Protein: 134-287
Range on HMM: 96-243/246.0
TET-------SVVLCNCGDSRAVLVSDGKvKFATSDHKP-SDEiETQRIKNAGGFI-EMGRVCGNLAVSRAIGDYEykDRPDLKPEEQkvtalsdTTSIS
 ..       |. . . |   |||. .|| |.  | .   ... | .|||.| ..| | ... | .. .| .| .     | . |. .         .. 
hdkvdPaksfsLevAsvGtlqavliRngk.klrlsksyviekd.elkrikeakaiitednkingviestrllGytf..lfPvvlPkph.......vrevl

RTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYclelGSKDNMSALLI
 |..||.|..  . .|.||  . .   |    .    | .. ||.  |    | .|..|.| .
LteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsy....gaadsvsvlvv

PPM_PTC7_SpoIIE_motif 227-287 7.1e-08 26.0 In-house 10-78 (81) alignment
Range on Protein: 227-287
Range on HMM: 10-78/81.0
PKDEFLVLACDGIWDVLtNEGVQL-----VVNFFLE-RGYDAERIADLLLDYCLELG---SKDNMSALLI
.... |.|..||...   ... .|     .. .. . .|......|| |.| .||.|   ..|... |..
kpgdvllLyTDGltEar.dsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl

subfamily_PPM1H_pd Subfamily PPM1H 100-176 3.3e-07 22.4 In-house 141-212 (404) alignment
Range on Protein: 100-176
Range on HMM: 141-212/404.0
SKGLFELDEAIKEKHpqlKAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPsdEIETQRIKN
 .  .|.|| |.. .   .| ... | |..   | .  . . | |||||.||  ....   .|. |  | | ||...
esaflemDeqiarer...eayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRlqe

Subfamily Dicty-PPM1L-like 138-198 3.6e-07 22.3 In-house 229-294 (305) alignment
Range on Protein: 138-198
Range on HMM: 229-294/305.0
VVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGG-----FIEMGRVCGNLAVSRAIGD
 |. . .|.. ||  ||. .    .... .  | .|.|  ..     | |. || ...||.| .||
lvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD

subfamily_PP2D1_pd Subfamily PP2D1 33-77 4.8e-07 21.8 In-house 13-57 (492) alignment
Range on Protein: 33-77
Range on HMM: 13-57/492.0
WRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQ
|. .|||.. .  .  | .| . |...||. |.|   .| . . .
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhe

subfamily_PPM1D_pd Subfamily PPM1D 190-260 2.5e-06 19.8 In-house 201-269 (309) alignment
Range on Protein: 190-260
Range on HMM: 201-269/309.0
LAVSRAIGDY-EYkdrpDLKPEEQKVTALSDTTSISRTPKDE-FLVLACDGIWDVLTNEGVQLVVNFFLERGY
|||.|..||   |    . | .|  |    |..   ..|..| |..|| ||.|.||| | .  ||.   | ..
LavaRslGDlWsy....naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekke