Gene PPM1A-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP129_AA protein Get Run
MbreP129_AA_15-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 20-290 2.6e-106 348.1 In-house 9-281 (282) alignment 
Range on Protein: 20-290
Range on HMM: 9-281/282.0
PNGLSYALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAY---TKGDKSAANLEQVLSKGLFELDEAIKEKHPQ
 ||| |..|||||||..|||||.| |.|..|.....|||||||.|..|.... . ....|...|..   .. .... .....|..|...|||||.|.. .
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

LKAGhDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPDLKPEEQKVTA
||.  |.||||... .|.|......|.|||||||...||..|.|.|||||.. |..||..|||.. ..||.|.||||||.||||||.....|.|||.|.|
lkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

LSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILFP
 ...|||.|. .|.|||||||||||||..| |  .|.  ||.....|..|. |.|..|| ||.||.|.|..||.
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
subfamily_PPM1G2_pd Subfamily PPM1G2 5-288 1.8e-80 262.9 In-house 2-285 (287) alignment 
Range on Protein: 5-288
Range on HMM: 2-285/287.0
LEKPVTEKHHDAATlPNGLSYALSSMQGWRIHMEDAHAVSADL---PNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTkgdksAANLEQVLSK
|..||..|......  .    . |.|||.|..||||| .  .|   .. .. |||||||||||..|.  ||. .|. |.. ....       .|||.| .
lsepvvakesasca.naltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.....egaleqilkd

GLFELDEAIKEKhPQLKAghDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEY
.. |.|| . ..  .||   . .||| .   ..|....  |.||||||| |.|.||  . ||||..| |..||..||||.|..||.||||.|||.||.|.
afletDeellkd.eklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfef

KDRPDLKPEEQKVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSK------DNMSALLIL
|.   .||||| |||. | .  .....|||||||||||||||||. |  .|.  | .| . ..|.. ||| ||   |.      |||..... 
kknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv
0034914 PP2C-like 16-291 1.3e-75 246.8 In-house 14-292 (295) alignment 
Range on Protein: 16-291
Range on HMM: 14-292/295.0
AATLPNGLSYALSSMQGWRIHMEDAHAVSADLPN-LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYT--KGDKSAANLEQVLSKGLFELDEAIKE
  .|.. |... .|.||.| ..|||. |  .|.. |....||.||||||| ...  | |...... .    .    . |  ..|..| |.. ..||.. |
lsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeelle

KHPQlKAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPDLKPEEQ
.  . .  ...||.|... ..... ....|.|||||||...|.... | ||||..| | .||..|||.. .|||.|.|||.||.||...|  . | ..|.
lall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllsllllep

KVTALSDTTSISRT-PKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILFPG
 |.|  |.|....| ..|.||.||.||.||||.|| .  .|. .|..|.|.| .|. |.|..|. ||.||...... ..|
lvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
PP2Cc_SM00332 19-287 2.4e-72 236.6 In-house 6-274 (274) alignment 
Range on Protein: 19-287
Range on HMM: 6-274/274.0
LPNGLSYALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKsAANLEQVLSKGLFELDEAIKEKHPQLK
  .||||..|||||||  |||||.|  || .  ....|.|||||||. |.  . . . .|. ..  . |...   . |..|.|.. ..||.| |.  ...
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqske

AGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKDRPdlKPEEQKVTALS
    .||||... ....  ....|.|||||||...||..  . ||||.|| |..|||.|||..| ||| |.||||||.||...|.    |..|. .||. 
lenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaep

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY--DAERIADLLLDYCLEL-GSKDNMSALLI
|.. .. |..||||.||.||.||||.|. |  .|. .|..|   |....|.|| .....  ||.||......
dvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 25-282 6.8e-70 228.5 Pfam-A 3-255 (255) alignment 
Range on Protein: 25-282
Range on HMM: 3-255/255.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE-LDEAIKEkHPQLKaG
.  |..||.| .|||||.  ..|       . |.|||||||||  ... |.|   . . . .  ....    ..|..|.|.  . .|| .|  . . .  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks.skant.e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPdlkpeEQKVTALS
...|||| .. ..... . . |.|||||||..... | . | ||||||| |..||..|||... .|||.|.||||||.||.|.|. .     || |.|  
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaeP

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNM
|.||...|..||||.||.||.||||... .  .|. .|. .......|. |.|.... ||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 25-282 6.8e-70 228.5 In-house 3-255 (255) alignment 
Range on Protein: 25-282
Range on HMM: 3-255/255.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE-LDEAIKEkHPQLKaG
.  |..||.| .|||||.  ..|       . |.|||||||||  ... |.|   . . . .  ....    ..|..|.|.  . .|| .|  . . .  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelks.skant.e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPdlkpeEQKVTALS
...|||| .. ..... . . |.|||||||..... | . | ||||||| |..||..|||... .|||.|.||||||.||.|.|. .     || |.|  
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaeP

DTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLELGSKDNM
|.||...|..||||.||.||.||||... .  .|. .|. .......|. |.|.... ||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 25-282 5.7e-69 225.4 In-house 3-259 (259) alignment 
Range on Protein: 25-282
Range on HMM: 3-259/259.0
YALSSMQGWRIHMEDAHAVSADLP---NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaaNLEQVLSKGLFE--LDEAIKEkHPQLKa
.  |..||.| .|||||.. |.|       . |.||||||||| .... |.|.. ... . .  ....    .||..|.|.  .  .|| .|  . . . 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelks.seant.

GHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVK-FATSDHKPSDEIETQRIKNAGGFIE---MGRVCGNLAVSRAIGDYEYKDRPDlkpEEQKVT
....|||| .. ..|.. .   |.|||||||...|... . | |||||.| | .||..|||...   .|||.|.||||||.||.|.|. .    |||.|.
epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvs

ALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGyDAERIADLLLDYCLELGSKDNM
|  |..|. ....||||.||.||.|||.... .  .|. .|. . |....|. |.|.... ||.||.
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
0049733 PP2C-like 23-289 5.6e-56 182.4 In-house 3-233 (235) alignment 
Range on Protein: 23-289
Range on HMM: 3-233/235.0
LSYALSSMQGW-RIHMEDAHAVsadlpnlpNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYtkgdKSAANLEQVLSKGLFELDEAIKEKHPQLKaGH
||.. .|..|. | ..|||..|        ...||||.|||||  ..  | |...... .  .      .  .||..| | . ...||. |.  . . ..
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalasp.el

DRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIemgRVCGNLAVSRAIGDYEYKdrpdlkpeeqkvtalSDTT
...|.|... ....  ....|.|||||.|..|||. . | ||.|..| | |||..|||..   || | ||..||.||...|                |.|
agmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvt

SISRTPKDeFLVLACDGIWDVLTNEGVQLVVNFflergYDAERIADLLLDYCLELGSKDNMSALLILF
..  .| | ||.||.||.||||..| .. ...      .|.| .|. |....|. |..||...... .
vlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 27-289 5.7e-47 153.1 In-house 8-262 (265) alignment 
Range on Protein: 27-289
Range on HMM: 8-262/265.0
LSSMQGWRIHMEDAHAVSADLPN------LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKsaanleQVLSKGLFELDEAIKEKHPQlkaG
. .... | .||| | .  || .       .. | |||||||||   .. | .   . . . |  ..  .      . | ... ..||.. .|  .    
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa......ealkeafkltDerflqkaer...e

HDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFI---EMGRVCGNLAVSRAIGDYEYKdrpdlkpeeQKVTAL
. .|||| .. ....  . .   |||.|.||..|..   .. |||..| | .||..|||..   .. || |.|.|||||||...|         . |.. 
klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsge

SDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY-DAERIADLLLDYCLELGSKDNMSALLILF
.|..... . ..|.|.|||||.|||...| |  .|. ||..|  | ...| ||..   | ||.||........
advaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 118-276 4.2e-46 150.9 In-house 291-451 (473) alignment 
Range on Protein: 118-276
Range on HMM: 291-451/473.0
KAGHDrSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIE-MGRVCGNLAVSRAIGDYEYKDRPDLKPEEQKVTA
. |.| ||.| .   . | ...  | ||||.|| ..||      |||| || |..||..||| ..  ||| | | .|||.||. ||   .|...|| ..|
epGed.sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

LSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGY--DAERIADLLLDYCLEL
| |      |..||||||||||||.|.. . |   |.  |. |     ..| . ||| ||  
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclap
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 26-289 5.9e-42 136.7 In-house 9-253 (255) alignment 
Range on Protein: 26-289
Range on HMM: 9-253/255.0
ALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEaytkgDKSAANLEQVLSKGLFELDEAIKEKHpqlkaghDRSG
. | | | |  |||  ..     . ..  ..|.||||||.. .. | | . . ...       |   || ...| |   |..  |.|.         . |
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaell.....dlnnanPvkslkkaykeistqiserp.......kfiG

STVICGFVTETSVVLCNCGDSRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMG----RVCGNLAVSRAIGDYeYKdRPDLKPEEQkvtaLSDt
.| .  ...|  |...| ||||.||   ||  |  . |||||.| |..||...||..  .    || |.||||||.||  .   | . |. .    ||. 
ttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fl.ePfvvpdPd....lsq.

tSISRTPKDEFLVLACDGIWDVLTNEG-VQLVVNFflergYDAERIADLLLDYCLELGSKDNMSALLILF
 |.  . ||.||.||||||||....|  |..|..       |.|. |  | |.  . ||.||.| ..| .
.sleiskkdkflilacdGiwdlisdeeaveivagi.....sdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 26-289 2.6e-41 134.6 In-house 8-266 (269) alignment 
Range on Protein: 26-289
Range on HMM: 8-266/269.0
ALSSMQGWRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTE---AYTKGDKSAANLEQVLSKGLFELDEAIKEkhpQLKAGHD
|  |..| | .|||   .  |. |  .  .|||||||||.. .  | ... .|| .     .  | ..   | ...| . .. .|| . |   ..|. .|
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklle...kakraed

RSGSTVICGFVTETSVVLCNCGDSRAVLVS-DGKVKFATSDHKPSDEIETQRIKNAGGFIEM---GRVCGNLAVSRAIGDYEYKDRpdlkpeeQKVTALS
 .|.|..  .|.|. ... | |||| ||.  .||    . |||| .  | .|||.||||| .    || | ||.|||.|||  ||.       . | |  
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadp

DTTSIS-RTPKDEFLVLACDGIWDVLTNEGvqlVVNFFLERGYDAERIADLLLDYCLELGSKDNMSALLILF
|  ..     | |||.||.||.|| ..||     |.| .||  . .  |  |   .   || ||.. |.. .
diltfdlddhkpeflilasdGlwdtfsnee...avrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
PPM_PTC7_SpoIIE 25-281 7.4e-37 120.4 In-house 3-229 (230) alignment 
Range on Protein: 25-281
Range on HMM: 3-229/230.0
YALSSMQGWRIHMEDAHAVSADL---PNLPNGALFAVFDGHGGKTvsTTAGEIFIQAITSTEaYTKGDksaaNLEQVLSKGLFELDEAIKEKhpqlkagH
.  |..||.| .|||||.. |..   .    .......|||||    . | . . .|. .   .. ..    ..|..|...  .|. .....       .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle....kpeeilrrlnlalaadlede.......p

DRSGSTVICGFVTETS--VVLCNCGDSRAVLVSD-GKvkfatsdhkpsdeiETQRIkNAGGFIE----MGRVCGNLAVSRAIGDYEYKDrpdlkpEEQKV
. ||.|.... .. ..  . ..|.|||...||.| |.              |  ||  |||...     ||| |.||||.|.||. ...      ... |
sssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvv

TALSDtTSISRT-PKDEFLVLACDGIWDVLTN-EGVQLVVNFFLERgydaerIADLLLDYCLELGSKDN
.|  | ||  ..  |||||.||.||.||||.. | |.||.. ...       .|. ||.... |.. ..
eaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDitllvvrv
subfamily_ILKAP_pd Subfamily ILKAP 29-264 4.9e-33 107.5 In-house 11-251 (293) alignment 
Range on Protein: 29-264
Range on HMM: 11-251/293.0
SMQGWRIHMEDAHAVSADLP---N-----LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTeaYTKGDKSA--ANLEQVLSKGLFELDEAIKEKHPQLK
  .| | .|.||| .  ||    .     . . . .||||||.|.  |  | | . . | ..  ..|.| ||   .. . | .   . ||   ..  . |
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktdeefLklaskak

aGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGK---VKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAVSRAIGDYEYKdrpdlkpeEQ
    . |||... .| .  .   | |||.||||    .|.   .   | ||.| .. | .||. |||... ||| | | |||.||| ..|        . 
.PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk........rl

KVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAER
 |..  |.. .  |. | |.||||||.|.|.... |   ..  ||  .| ..
GvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrk
subfamily_PPM1K_pd Subfamily PPM1K 28-289 7.2e-33 106.8 In-house 9-258 (263) alignment 
Range on Protein: 28-289
Range on HMM: 9-258/263.0
SSMQGWRIHMEDAHAVSADLPNLpngALFAVFDGHGGKTVSTTAGEIFIQAITSteaYTkgdKSAANLEQVLSKGLFELDEAIKEKHPQL--KAGHDRSG
 |..| |   ||   .    |.|     .||||||.| .    . . . . ..    .    .   .||.|| . . |||...|     .  .| .  ||
dsliGkraenedriklkeldpel...lyvavfdGhaGsaaadfvhdklekilkr...ll...ekekdleivlknafeeldkklkrylefsvaeaellssG

STVICGFVTE-TSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEM-----GRVCGNLAVSRAIGDYEYKdrpdlkPeeQKVTALSD
.|    .. . | .|| . |||||.|  .|| |  |.||.|. | | .|||.|||..|.      .| | ||..|..|| . |      .    | |  .
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk......r..yGviatPe

TTSISR-TPKDEFLVLACDGIWDVLTNEGVQlvvnFFLERGYDAERIADLLLDYCLELGSKDNMSALLILF
| |.     .| ||||  ||| .|.... .     ....   | |. |. | .  |. ||.|| .|... .
tkslkvdhaadsflvlitdgisfvvnsqelc....dlvrlchdpeeaahalteqalqygsednatavvvpl
subfamily_KAPP-like_pd Subfamily KAPP-like 45-286 3.3e-29 94.7 In-house 26-263 (266) alignment 
Range on Protein: 45-286
Range on HMM: 26-263/266.0
ADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVlSKgLfeLDEAIKEKHPQLKAgHDRSGSTVICGFVTE----TSVVL
 .| |  | ||||||||| || .. .| ..| . .      || |.   |  .  || |  |..|.||   .||  ..  |.|    .| .      .  
kklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydq.sk.l..lenafkevdaklkd.feyeGatatlalvwsdGqqrylqv

CNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVC-GNLAVSRAIGDYEYKDRPDLKPEEQKVtalSDttSISRTPKDEFLVLACDGI
.| ||| | |    .  . . |||  |. | ||||. |  .  ..     ||||||.||.  |..      |  |   |.   |. ||.|.||..| ||.
anvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyv...sn..rilltpfdkflivasdGl

WDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLE-LGSKDNMSALL
|||.. .    .|. . ...  ....|. ||.  ..   .|||.| ..
wdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 45-286 4.2e-26 84.4 In-house 25-273 (276) alignment 
Range on Protein: 45-286
Range on HMM: 25-273/276.0
ADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQAITS-----TEAYTKGDKSAANLEQvlSKGLFelDEAIKEKHPQLKAgHDRSGSTVICGFVTETS--
 || |  | ||||||||| || .. .| ..| . .         . || |.   |  .   ..|.   ...||   .||  ..  |.|    .| .    
kdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniyd..qskll..ldlfkevdaklkd.feyeGatatlalvwsdGee

--------VVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVC-GNLAVSRAIGDYEYKDRPDLKPEEQKVtalSDttSISRTPK
        .  .| ||| | |    .  . . ||| .|  | ||||. |  .  ..     ||||||.||.  |..      |  |   |.   |. ||.
qqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyv...sn..rilltpf

DEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYCLE-LGSKDNMSALL
|.||..| ||.|||.. .    .|. . ...  ....|. ||.  ..   .|||.| ..
dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv
subfamily_PPM1D_pd Subfamily PPM1D 28-183 2.5e-21 69.1 In-house 7-173 (309) alignment 
Range on Protein: 28-183
Range on HMM: 7-173/309.0
SSMQGWRIHMEDAHAVSADLPNLP---NGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKgdKSAANLEQVLSKGLFELDEAIKEK---HPQLKAGH
.. || | .|||  |.. .  .     . | .|||||||||  .. | |  .. |.  . ..   .. ... . .... ... ||.|.|    |. | |.
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkfls..sepedvleAireaflatheamkkkleeWpktksgl

D-RSGSTVICGFVTETSVVLCNCGDSRAVLVSDGK------VKFATSDHKPSDEIETQRIKNAGGFIEM
   .|.|. . ..... . . . |||..|| .. .       |  |.||||..  |..||...|| . .
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_PPM1G_pd Subfamily PPM1G 4-113 1.4e-20 66.8 In-house 1-102 (473) alignment 
Range on Protein: 4-113
Range on HMM: 1-102/473.0
FLEKPVTEKHHDAAtLPNGLSYALSSMQGWRIHMEDAHAVSADLPNlpNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDksaanLEQVLSKGL
.|.|| .||...     ..|||. |.|||||  .|||| .  || .  . .||||.|||||| |..   . . . .. ...| .||     .|. |..  
ylskpkvekesede.sneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgykegd.....vekaleeaf

FELDEAIKEK
..||| .|..
lalDeklkae
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 55-188 3.2e-19 62.6 In-house 23-155 (292) alignment 
Range on Protein: 55-188
Range on HMM: 23-155/292.0
LFAVFDGHG--GKTVSTTAGEIFIQAITSTEAYtKGDKSAANLEQVLSKGlfeldeaIKEKHPQLKAGhDRSGSTVICGFVTET-SVVLCNCGDSRAVLV
| ||.||||  |. |.  | . . . ....    . . | | | ..|. .        | ..  ..|.  .....|.|  | .  ...| | |||||.| 
laavldGhGvnGdkvaqlaedtlevelleltrq.lqelsealllrildia.......akldkltidar.esattavvcarvrddralilanvGdsrallg

S-----DGKVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCG
      | ...  . ||||.|  | .||..|||..|  || |
rclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg
subfamily_PDP_pd Subfamily PDP 95-259 1.4e-18 60.1 In-house 115-315 (398) alignment 
Range on Protein: 95-259
Range on HMM: 115-315/398.0
LEQVLSKGLFELDEAI-KEKHPQL-------KAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGKVKFA--TSDHKPSDEIETQRIKNAG---
....|.|.  .||. | .|  ..|       ..    ||.. .. .. .|.. . | ||.|||| .   .|...    ..|.  . | | .|||..    
vkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPge

---GFIEMGRVCGNLAVSRAIGDYEYKDRPDLKP---EE------Q--------KVTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLER
     |  ||. |.|. .|| ||..||   .|.    |.      .         .||  . ||   ...| ||||| ||.||.|.|| |  .|. .|..
esktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlak

G
 
k
subfamily_PP2D1_pd Subfamily PP2D1 118-256 4.6e-18 58.2 In-house 170-306 (492) alignment 
Range on Protein: 118-256
Range on HMM: 170-306/492.0
KAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGGFIE----MGRVCGNLAVSRAIGDYEykdRPDLKpeeQK
. | ... ..     .  . . . | |. .|||. .|| .  | .| | .. | .|...||. .     .|.| | | . | .| |     |.||   . 
eeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpkLk...ks

VTALSDTTSISRTPKDEFLVLACDGIWDVLTNEGVQLVVNFFL
|     |||.  . .. |||||  |.|.||..| |  .|. .|
vipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl
PP2C_SIG_SM00331 50-286 3.4e-15 49.2 In-house 26-214 (217) alignment 
Range on Protein: 50-286
Range on HMM: 26-214/217.0
LPNG-ALFAVFDGHGgktVSTTAGEIFIQAITSTEAYTKGDksaanleQVLSKGLFELDEAIKEKhpqlkAGHDRSGSTVICGFV--TETSVVLCNCGDS
|..|  |..|.||.|       |...  |. |  . . . .       . ||. | .|..||.|.     .. .... |.... .  ..  . ..|.|||
lnegrlllvvaDgmG...kGlaAaaassqlrtalrellseg.......eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGds

RAVLVSDGKVKFATSDhkpsdeietqriknaggfiemgrvcgnlavsraigdyeY-----------KdrpdlkpeeqkvtalSDTTSISRTPkDEFLVLA
| .|. ||| .. ..|                                                  .                |.....  . ...|.|.
rpyllrdgklveilkd......................................vegaplGlepevs...............vdirelelek.gdlllly

CDGIWDVL-----TNEGVQLVVNFFLerGYDAERIAD----LLLDYCLELGSKDNMSALL
 ||....       .| .....  ..  .  |...|.     || .  . . .|... ..
tDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvv
PPM_PTC7_motif 233-282 7.2e-13 41.8 In-house 1-51 (51) alignment 
Range on Protein: 233-282
Range on HMM: 1-51/51.0
VLACDGIWDVLTNEGVQLVVNFFLERGY-DAERIADLLLDYCLELGSKDNM
.||.||.||||... .  .|. .|.  . . ...|  | |..|. ||.||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_2 Protein phosphatase 2C 49-246 7.9e-12 37.9 Pfam-A 20-184 (212) alignment 
Range on Protein: 49-246
Range on HMM: 20-184/212.0
NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVLSKGLFELDEAIK---EKHPQlKAGHDRSGSTVICGFVTETSVVLCNCGD
.  .| |.|| ||.|    |  . ... .|.... . .  ..|... |..| . . |.....|   |.. | ..  .  ..|... ..|.. .|....||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGD

SRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMgrvcgnlavsraigdyeykdrpdlkpeeqkvtalsdTTSISRTPKDEFLVLACDGIWDVLT
...|.. .||.|. ......   . ||.... .  . |.                                     ... .... . |.|  ||..| |.
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel....................................rirrlklepgdalllmTDGvsdslr

NE
.|
ke
PP2C_2 Protein phosphatase 2C 49-246 7.9e-12 37.9 In-house 20-184 (212) alignment 
Range on Protein: 49-246
Range on HMM: 20-184/212.0
NLPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAYTKGDKSAANLEQVLSKGLFELDEAIK---EKHPQlKAGHDRSGSTVICGFVTETSVVLCNCGD
.  .| |.|| ||.|    |  . ... .|.... . .  ..|... |..| . . |.....|   |.. | ..  .  ..|... ..|.. .|....||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavitpgeivffqiGD

SRAVLV-SDGKVKFATSDHKPSDEIETQRIKNAGGFIEMgrvcgnlavsraigdyeykdrpdlkpeeqkvtalsdTTSISRTPKDEFLVLACDGIWDVLT
...|.. .||.|. ......   . ||.... .  . |.                                     ... .... . |.|  ||..| |.
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel....................................rirrlklepgdalllmTDGvsdslr

NE
.|
ke
subfamily_TAB1_pd Subfamily TAB1 121-203 3.3e-10 32.3 In-house 126-218 (333) alignment 
Range on Protein: 121-203
Range on HMM: 126-218/333.0
HDRSGSTVICGFVTETSVVLCNCGDSRAVLVS---DGKVKFATSDHKPSDEIETQRIKNAGGF---IEMGRVCGNLAVSRAIGDYEYK----D
. . |.| .   .    .   |.|||||.||      |||   .||.   | | .|.|. |     |.  .. |.    |.||||. |    |
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykd
subfamily_PPM1H_pd Subfamily PPM1H 185-258 4.2e-09 28.6 In-house 276-353 (404) alignment 
Range on Protein: 185-258
Range on HMM: 276-353/404.0
RVCGNLAVSRAIGDYEYKDR---PDLKPEEQKVTAL--SDTTSISrTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLER
|. . ..|.| .||.| |       .||    |  .   | |... . .|. |.|| ||.||||.|| |  .|. .|..
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqve.sleDdvlilatDGLWdvlsneevaeivrevlsk
subfamily_PHLPP_pd Subfamily PHLPP 134-287 1.2e-08 27.2 In-house 96-243 (246) alignment 
Range on Protein: 134-287
Range on HMM: 96-243/246.0
TET-------SVVLCNCGDSRAVLVSDGKvKFATSDHKP-SDEiETQRIKNAGGFI-EMGRVCGNLAVSRAIGDYEykDRPDLKPEEQkvtalsdTTSIS
 ..       |. . . |   |||. .|| |.  | .   ... | .|||.| ..| | ... | .. .| .| .     | . |. .         .. 
hdkvdPaksfsLevAsvGtlqavliRngk.klrlsksyviekd.elkrikeakaiitednkingviestrllGytf..lfPvvlPkph.......vrevl

RTPKDEFLVLACDGIWDVLTNEGVQLVVNFFLERGYDAERIADLLLDYclelGSKDNMSALLI
 |..||.|..  . .|.||  . .   |    .    | .. ||.  |    | .|..|.| .
LteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsy....gaadsvsvlvv
PPM_PTC7_SpoIIE_motif 227-287 7.1e-08 26.0 In-house 10-78 (81) alignment 
Range on Protein: 227-287
Range on HMM: 10-78/81.0
PKDEFLVLACDGIWDVLtNEGVQL-----VVNFFLE-RGYDAERIADLLLDYCLELG---SKDNMSALLI
.... |.|..||...   ... .|     .. .. . .|......|| |.| .||.|   ..|... |..
kpgdvllLyTDGltEar.dsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl
subfamily_PPM1H_pd Subfamily PPM1H 100-176 3.3e-07 22.4 In-house 141-212 (404) alignment 
Range on Protein: 100-176
Range on HMM: 141-212/404.0
SKGLFELDEAIKEKHpqlKAGHDRSGSTVICGFVTETSVVLCNCGDSRAVLVSDGKVKFATSDHKPsdEIETQRIKN
 .  .|.|| |.. .   .| ... | |..   | .  . . | |||||.||  ....   .|. |  | | ||...
esaflemDeqiarer...eayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRlqe
Subfamily Dicty-PPM1L-like 138-198 3.6e-07 22.3 In-house 229-294 (305) alignment 
Range on Protein: 138-198
Range on HMM: 229-294/305.0
VVLCNCGDSRAVLVSDGKVKFATSDHKPSDEIETQRIKNAGG-----FIEMGRVCGNLAVSRAIGD
 |. . .|.. ||  ||. .    .... .  | .|.|  ..     | |. || ...||.| .||
lvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_PP2D1_pd Subfamily PP2D1 33-77 4.8e-07 21.8 In-house 13-57 (492) alignment 
Range on Protein: 33-77
Range on HMM: 13-57/492.0
WRIHMEDAHAVSADLPNLPNGALFAVFDGHGGKTVSTTAGEIFIQ
|. .|||.. .  .  | .| . |...||. |.|   .| . . .
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhe
subfamily_PPM1D_pd Subfamily PPM1D 190-260 2.5e-06 19.8 In-house 201-269 (309) alignment 
Range on Protein: 190-260
Range on HMM: 201-269/309.0
LAVSRAIGDY-EYkdrpDLKPEEQKVTALSDTTSISRTPKDE-FLVLACDGIWDVLTNEGVQLVVNFFLERGY
|||.|..||   |    . | .|  |    |..   ..|..| |..|| ||.|.||| | .  ||.   | ..
LavaRslGDlWsy....naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekke