Gene PPM1A-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP131_AA protein Get Run
MbreP131_AA_127-512 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 129-513 2.3e-110 361.4 In-house 4-282 (282) alignment 
Range on Protein: 129-513
Range on HMM: 4-282/282.0
KSQAELLPVRAGVETWSGRKNDNEDRYDVAMSMGAL--GRLFAVYDGHAGSECADYVKKCLPGNIVGgyrggvvgcegtdaelqelQSQMSEaqqslvel
|||||....|.||....|.....||...|..|.|||  ...|||.|||||||.|.||||.|..||..                   .....|        
ksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile...................eeelke........

tAALEATPDDESLQQMQQQLLAQHEAKSGLSTDYQTAvLKCvkdgykctdknwlsmaikkkkqgGSTSLTIMLNgssttNAHLIIANLGDCRAVMCRGTR
 |||||...||......|..||..||...||||..|| .|.                       |||..|....     ..|||||||||.|||.||...
.aaleasekdevkealrqgfLaldeairelstdlkta.dks.......................GsTavtvlvs.....ekhliianlGDsRavlcrngk

AHRLTQDHKPDRPDEKKRIQQAGGHVVnvmgVSRVMGAredreprqalmLAVSRSFGDYALKT------PKLLVSHVPEV-SIERIEDKDyFFVIACDGI
|..||.||||.||.|||||.||||.||    ||||.||           |||||..|||..|.      ...|||..||| ||||.|..| |.|.|||||
aaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa...........LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGi

WDVLSDQEVVDLARKHYGQAqDGMMTLpsyalaqegsgvglclfqglgfskclkdqpvfclfvpcvaaARAIVRKAYEAGSGDNLTALVVEFAW
||||||.|||.|.||....| |.....                                         |.|.|.||.|.||.|||..|||.||.
wDvlsdeevvelvrkrleva.deleev.........................................akalvdkalekgsrDNlsvlvvlfak
0034914 PP2C-like 128-512 8.8e-60 195.0 In-house 12-291 (295) alignment 
Range on Protein: 128-512
Range on HMM: 12-291/295.0
FKSQAELLPVRAGVETWSGRKNDNEDRYDVAMSM---GALGRLFAVYDGHAGSECADYVKKCLPGNIVggyrggvvgcegtdaelqelqsqmseaqqslv
...  .|| .|.|| .  ||.. |||.. | ...      . ||.|.||| |...|..... |. ...                                
lllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelll................................

eltaaleatpddeslQ-----------QmqqqllaqheaksglstdyQTAVLKCVKDGYKCTDKNWLSMAIK--KKKQGGSTSLTIMLNGSsttnaHLII
               .                               .. .......... .|.  |..|..  .   .|.| ..... |.     .|..
...............ellekllllltls...................ledieealrkaflaadeellelallrpelagsGtTavvalirgn.....klyv

ANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNvmgvsrvmgaredrePRQALMLAVSRSFGDYALKTP------KLLVSHVPEVSIERI
||.||.|||..|. ....|| ||||....|..||..||| |..               .|   .|||.|..||. ||..      . ||| .|.|.. ..
anvGDSravllrngelvqltvdhkpvnelererilsaggavsh...............grvngvlavtRalGdfdlklllslllleplvsaePdvtvlel

E-DKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQDgmmtlpsyalaqegsgvglclfqglgfskclkdqpvfclfvpCVAAARAIVRKAYEAGSGDNL
. ..| |...|.||.|||||..|.||..|... . .|                                          . .||...|. |...|| ||.
tledddfllLasDGlwdvlsneeivdivrsllakgld..........................................leeaaeeLvdlAlargsrDNi

TALVVEFA
|..|| . 
Tvvvvrln
PP2Cc_SM00332 138-509 3.6e-57 186.8 In-house 11-274 (274) alignment 
Range on Protein: 138-509
Range on HMM: 11-274/274.0
RAGVETWSGRKNDNEDRYDVAMSM--GALGRLFAVYDGHAGSECADYVKKCLPgNIVGGYRGGVVGCEgtdaelqelqsqmseaqqslveltaaleatpd
. |. .  |... .||.. | ...   . . .|.|.|||.|||.|..|.|.|| ...     .. ...                                
sygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklp.ealkeelkkkkdel................................

deslqqmqqqllaqheaksglstdyQTAVLKCVKDGYKCTDKNWLSMAIKKKK---QGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAHRLTQ
                         . .| .. |.... ||.. | .. .|..     ||| ....|..       |..||.||.|||.||.  |..|..
.........................eddveealkkaflstdeeileeeqskelenalsGstavvallkked.....lyvanvGDSravlcrngkavqlsv

DHKPDRPDEKKRIQQAGGhvvnvmgvsrvmgARE-DrepRQALMLAVSRSFGDYALKTPK----LLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQE
||||...||.|||..|||               | .   |   .|||||.|||..||..|      ... |.|..... ..| |...|.||.|||||.||
dhkpedederkRikkagg.............vvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqe

VVDLARKHYGQAqdgmmtlpsyalaqegsgvglclfqglgfskclkdqpvfclfV--PCVAAARAIVRKAYEA-GSGDNLTALVV
|||. ||.  .                                           .   . .||  ....|... || || |..||
vvdivrkllakg..........................................ktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 257-442 1.6e-50 165.1 Pfam-A 70-235 (255) alignment 
Range on Protein: 257-442
Range on HMM: 70-235/255.0
StdyqtAVLKCVKDGYKC-TDKNWLSMAIK-KKKQGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAH-RLTQDHKPDRPDEKKRIQQAGGHVV
       | |......   ||..  |.. . .  . |||.......|.      |..||.||.|||.||...|. .||.||||...||..||..||| | 
e.....kvekalrksfladtdeelksskantepsksGstavvalirgkk.....lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvs

NvmgVSRVMGAredreprqalmLAVSRSFGDYALKT-PKLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQDG
|   . || |            |||||..||. ||  .. |||. |.|.  .....| |...|.||.||||||||.|||.|..  . .. 
n...ngrvngs...........LavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkksp
PP2C Protein phosphatase 2C 257-442 1.6e-50 165.1 In-house 70-235 (255) alignment 
Range on Protein: 257-442
Range on HMM: 70-235/255.0
StdyqtAVLKCVKDGYKC-TDKNWLSMAIK-KKKQGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAH-RLTQDHKPDRPDEKKRIQQAGGHVV
       | |......   ||..  |.. . .  . |||.......|.      |..||.||.|||.||...|. .||.||||...||..||..||| | 
e.....kvekalrksfladtdeelksskantepsksGstavvalirgkk.....lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvs

NvmgVSRVMGAredreprqalmLAVSRSFGDYALKT-PKLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQDG
|   . || |            |||||..||. ||  .. |||. |.|.  .....| |...|.||.||||||||.|||.|..  . .. 
n...ngrvngs...........LavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkksp
PPM_PTC7 259-439 2.9e-50 164.1 In-house 70-239 (259) alignment 
Range on Protein: 259-439
Range on HMM: 70-239/259.0
DyqtAVLKCVKDGYKC--TDKNWLSMAIK-KKKQGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAH-RLTQDHKPDRPDEKKRIQQAGGHVVN
.    . |......    ||..  |.. . .....||| ......||      |..||.||.|||.||. .|. .||.||||...||..||..||| | |
e...klekalrksflaldtdeelksseantepstsGstAvvalitgsk.....lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsn

VmGVSRVMGAredreprqalmLAVSRSFGDYALKT---PKLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQ--A
| |..|| |            |||||.|||. ||     . |||. |..|   |...| |...|.||.|||.||||.|||.|..  .  .
v.gngrvngv...........lavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdp
0049733 PP2C-like 137-511 3.8e-45 147.0 In-house 3-233 (235) alignment 
Range on Protein: 137-511
Range on HMM: 3-233/235.0
VRAGVETWSGR-KNDNEDRYDVamsmgaLGRLFAVYDGHAGSECADYVKKCLPGNIVGGYRGgvvG---Cegtdaelqelqsqmseaqqslveltaalea
...|. .. || .. |||.. |       . ||||.||| |....... ..|. ...  ...                                      
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllellle...lllld..............................

tpddeslqqmqqqllaqheaksglstdyqtaVLKCVKDGYKCTDKNWLSMAIKK--KKQGGSTSLTIMLNgssttNAHLIIANLGDCRAVMCRGTRAHRL
                               ....... .. ... .|..|..      .|.| ....|      . .|..||.||.||...|. ....|
...............................leealrkaflaaneallelalaspelagmgtTavvalld.....ggklyvanvGDsrayllrdgklvql

TQDHKPDRPDEKKRIQQAGGHVvnvmgvsrvmgaredrepRQALMLAVSRSFGDYALKtpkllvshvPEVSIERIEDKDyFFVIACDGIWDVLSDQEVVD
|.||.| ...|..||..|||.|                  |   .||..|..||. ||         |.|.. ..|. | |...|.||.||||||.|.||
tedhspvnelerqriitaggav..................rvpgrlaltralGdlllk.........pdvtvlelepgd.flllasDGlwdvlsdeeivd

LARKhygQ-AqdgmmtlpsyalaqegsgvglclfqglgfskclkdqpvfclfvpcVAAARAIVRKAYEAGSGDNLTALVVEF
| |.   . .                                              .||...|. |...|. ||.|..|| .
llrs...ldl.............................................eeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 167-439 2e-41 134.8 In-house 54-250 (287) alignment 
Range on Protein: 167-439
Range on HMM: 54-250/287.0
LFAVYDGHAGSECADYVKKClpgnivggyrggvvgcegtdaelqelqsqmseaqqslveL-----TaaleatpddeslqqmqqqllaqheaksglSTDY-
||||.||| |...| |. |                                        |     .                              ... 
lfavfDGhGGakvakyagkk.......................................likkiak.............................kksfk

QTAVLKCVKDGYKCTDKNWLSMAIKKKKQGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVvnvmGVSR
. |. ...||... ||.. |.    |... |||....... ..     |..|| || |||..  .... |. ||||.. .|||||..||| |     . |
egaleqilkdafletDeellkdeklkdesaGstavvvlikeek.....lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv....elnr

VMGAredreprqalmLAVSRSFGDYALKTPK------LLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQA
| |.           ||.||..||.. |. .       .|  ||.| .......| | |.|||||||||...||||| |..  . 
vngn...........LalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg
subfamily_PPM1L_pd Subfamily PPM1L 144-442 1.6e-36 119.0 In-house 12-242 (269) alignment 
Range on Protein: 144-442
Range on HMM: 12-242/269.0
WSGRKNDNEDRYDVAMSM--GALGRLFAVYDGHAGSECADYVKKCLPGNIVGGYRGGvvgcegtdaelqelqsqmsE-------Aqqslveltaaleatp
  ||..  |||....  .  ..  ..|||.||| |   |...|. |. .|                          .                       
vlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel...................dadkentep...............

ddeslqqmqqqllaqheaksglstdyqTAVLKCVKDGYKCTDKNWLSMAIKKKKQGGSTSLTIMLNGSsttnaHLIIANLGDCRAVMCRG-TRAHRLTQD
                            .  | ..|   . |.. |  | ....  |.|.|  ....|     .||.||.|| | |..    .|  |. |
...........................infsklltdeilsvdekllekakraediaGttalialvqes.....dlivanvGdsrGvlydkrGkaiplsfd

HKPDRPDEKKRIQQAGGHVvNVMGVSRVMGaredreprqalMLAVSRSFGDYALKTPKLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLAR
||| .. |.|||..||| .    || || |           .||.||..||| ||  .|....   ....  . |  |...|.||.|| .|..| |  ..
hkpqqvkerkrikkaGGfi.afrGvwrvaG...........vlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfik

KHYGQAQDG
.. .. . |
erlkepdfG
subfamily_PPM1E_pd Subfamily PPM1E 259-442 4.5e-36 117.4 In-house 75-234 (265) alignment 
Range on Protein: 259-442
Range on HMM: 75-234/265.0
DYQtavlKCVKDGYKCTDKNWLSMAIKKKKQGGSTSLTIMLNGSSttnahLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNVmGV
| .    . .|...| ||.. |. |...| ..|||. .......      | .| ||| .|...| ..| .|.. |||.|.||||||..||| ||.. |.
dpa....ealkeafkltDerflqkaereklksGstavvvliekdq.....lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi.ga

SRVMGaredreprqalMLAVSRSFGDYALKTpklLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQDG
 || |           .|.|||. ||. ||     ||  ..|.  ........ ..||||.|||. ..|||.| ...  . .. 
wRvnG...........vLsvsRaiGDvklkp...yvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaed
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 260-450 5e-33 107.4 In-house 69-237 (255) alignment 
Range on Protein: 260-450
Range on HMM: 69-237/255.0
YQTAVLKCVKDGYKCTDKNWlsmaIKKKKQGGSTSLTIMLngsstTNAHLIIANLGDCRAVMC-RGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNVMGV
.... .|..|. || ..        .. |  |.|. ....     .. . .|||.|| |.|.| . . |.||. ||||  ..|.|||...|| ||. .  
nnanPvkslkkaykeistqi....serpkfiGttaasvli.....iedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvt

SRVMGaredreprqalMLAVSRSFGDYALKtPklLVSHVPEVS-IERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHyGQAQDGMMTLPSYA
||| |           .|||||..||  |. |   |   |..|   .|  || |...|||||||..||.| |... .   ....  ..|  .|
srvnG...........tlavsralGdsfle.P..fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi.sdpekaaeklrdla
subfamily_ILKAP_pd Subfamily ILKAP 240-440 6.6e-31 100.5 In-house 63-247 (293) alignment 
Range on Protein: 240-440
Range on HMM: 63-247/293.0
QQMQQQLLaQHEAKSGLSTDYqTAVLKCVKDGYKCTDKNWLSMAIKKKK--QGGSTSLTIMLngsstTNAHLIIANLGDCRAVMCRGTRAHR------LT
.......| .. .|| .|.   . . ||. | .| ||...|..| |.|   . |||  ...       .  | .||||| .||..|   . .      ||
eklhkkil.eklpksdvsake.keikkclvdsfkktdeefLklaskakPvWkdGstatvvlv.....ldnvlyvanlGdskavlvrkkeegdkiasvvLt

QDHKPDRPDEKKRIQQAGGHVVNvmgvSRVMGaredreprqalMLAVSRSFGDYALKTpkLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDL
.||.| . .|.||||.|||.| .    .||.|           .| |||| ||   |.  | |. .|.|.  .... | | |.||||.|.|.| .|||. 
kdhtpvkyeerkriqkaGgvvrd....grvlG...........vlevsrsiGdgrfkr..lGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkf

ARKHYGQAQ
. |  ....
ilkvledee
subfamily_PPM1G_pd Subfamily PPM1G 285-441 1.1e-30 100.1 In-house 291-434 (473) alignment 
Range on Protein: 285-441
Range on HMM: 291-434/473.0
KKKKQGGSTSLTIMLNGssttnAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNvmgVSRVMGAredreprqalmLAVSRSFGD
.. .. |.|   ..|..      .||.|| ||.|.|..|  .|  |  ||||. . |..||..|||.|       || |            | .|| .||
epGedsGttAvvaLlke.....kklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvde...dgRvnGG...........LnlsRAlGD

YALKTPKLL------VSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQD
.| |. . |      .| .|.. .. . ..| |.|.||||||.|.. |||||  |..  . ..
haYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgee
subfamily_PDP_pd Subfamily PDP 151-441 3.6e-29 95.0 In-house 11-317 (398) alignment 
Range on Protein: 151-441
Range on HMM: 11-317/398.0
NEDRYDVAMSMGALGRLFAVYDGHAGSECADYVKKCLPGNIVGGY--RGGVVGCEGTDAELQELQSqMSEAQQSLVELTAALEATPDDESLQ-QMQQQLL
.|||. .| .. . | ||.| |||.|  ||. |.| |.  ..     .  ..  | .  . ..|.. ... ... .. ..  ... . ..|. ..|..| 
iEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallk.llkkskhkldvvsdeakklslselskylqelle

AQHEaksglstdyqtAVLKCVKDGYKCTDKNWLSMAIKKKKQGGSTS-LTIMLNGSSTTNAH-----LIIANLGDCRAVMCRG-----TRAHRLTQDHKP
|. |            | . .| ...  ||.  . |.||.|.  ... |.  | |. ...|.     | .|| ||||||...        | .|..|.  
aeve...........kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqta

DRPDEKKRIQQAGGHVVN--VMGVSRVMGAR------------EDREPRQALMLAVSRSFGD-YALKTPKLLVSHvPEVSIERIEDKDYFFVIACDGIWD
| ..| .||...  .  .  |.  .|..|               ..|  . ..  ..  .     .|||  | .. |||   ... .| |.|.| ||.||
dneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltae.PevtshklrendkFLvlatDGLwd

VLSDQEVVDLARKHYGQAQD
.||..|||.|  .|. ....
llsneevvslVgehlakkke
subfamily_PPM1D_pd Subfamily PPM1D 242-435 2.7e-28 91.9 In-house 53-264 (309) alignment 
Range on Protein: 242-435
Range on HMM: 53-264/309.0
MQQQLLAQHEAKSGLSTDYQTAVLKCVKDGYKCTD-------KNWLSMAIKKKKQGGSTSLTIMLngsstTNAHLIIANLGDCRAVMCRGTR------AH
 ...|. . . .... .. . .||. .....  |        ..|   . ..    |.|  ....     .. .| .|. || ..|.           |.
arehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvvii.....rreklyvahvGDsaivlgvkepkekklrak

RLTQDHKPDRPDEKKRIQQAGGHVVNVMGVSRVMGAR---EDREP---RQALMLAVSRSFGD---YALKTPKLLVSHVPEVSIERIEDKDY-FFVIACDG
 ||.||||. |.||.||...||.| .  ||.||.  |   | ..|    .   |||.|| ||   |  |. . .|| .|.|.  ... ..  | ..| ||
eltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDG

IWDVLSDQEVVDLARKH
.|.||. ...|.. .|.
lwnvltpedavsvveke
subfamily_PPM1K_pd Subfamily PPM1K 277-434 4.1e-26 84.7 In-house 85-227 (263) alignment 
Range on Protein: 277-434
Range on HMM: 85-227/263.0
KNWLSMAIKKKKQGGSTSLTIMLNGSsttnAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVV-NVMGvsrvmgaredrEPRQALM
   .|.| ..... |.|.   .|        .|..|.||| ||..||  .|..||.||.|.. .||.||..|||.|  | .|           .|.   .
ylefsvaeaellssGttatvsllrdG....telvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslg...........kplvngr

LAVSRSFGDYALKTPKLLvsHVPEVSIERI-EDKDYFFVIACDGIWDVLSDQEVVDLARK
||..||.||  ||.  ..    ||    ..  ..| |.|.  ||| .|...||. || |.
lamtrslGdldlkryGvi..atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
PPM_PTC7_SpoIIE 281-438 1.5e-21 70.3 In-house 87-211 (230) alignment 
Range on Protein: 281-438
Range on HMM: 87-211/230.0
SmaikkKKQGGSTSLTIMLNGSSttnAHLIIANLGDCRAVMCRGtR-AhrltqdhkpdrpdEKKRIqQAGGHVVnV-MGVSRVMGAredreprqalmLAV
.      ...|.| . . ...|.    .| .||.||......|.                 |..|| .||| .  . ..  || |            |||
e.....psssgaTavvalidpst...gklyvanaGdsppllvrd.dgg.............ereri.vagglps.lGilpgrvfgv...........lav

SRSFGDYALKTPKLLVSHVPEVSIERIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQ
|...||. |.    .|.. |. | .. ..|| | ..|.||.|||||.||.|||.|.. ..
slapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelek
subfamily_PP2D1_pd Subfamily PP2D1 304-440 2.2e-21 69.1 In-house 185-310 (492) alignment 
Range on Protein: 304-440
Range on HMM: 185-310/492.0
TTNAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNVMGVSRVMGAredreprqalmLAVSRSFGDYALKTPKLLVSHVPEVSIE
   . | ||| |. .||.||. .| .||..| |  . |..|...||. ||.   ...| |.           | . |  | |     |  |   |..   
eelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGi...........ldttRGLGnyGdpkLkksvipePkttsv

RIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQ
 ..... | |.|  |.|.|||..||. |...   . .
kldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_KAPP-like_pd Subfamily KAPP-like 284-440 1.8e-18 59.5 In-house 94-236 (266) alignment 
Range on Protein: 284-440
Range on HMM: 94-236/266.0
IKKKKQGGSTSlTIMLNGSSTTNAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNvmGVSRVMGaredreprqalmLAVSRSFG
.|. .  |.|. |. |  |.    .| .||.||  | ..||  .  |..||| . |.||.||.. |  . .  . .|. |            |||||..|
lkdfeyeGata.tlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsd..nqtrinG............lavsralG

DYALKTPKLLVSHVPEVSIE-RIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQ
|. .|   . ..  | || .  .  .| | ..| ||.|||.| .. ..  .  | | .
dhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqa
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 304-440 8.6e-18 57.2 In-house 123-246 (276) alignment 
Range on Protein: 304-440
Range on HMM: 123-246/276.0
TTNAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPDEKKRIQQAGGHVVNvmGVSRVMGaredreprqalmLAVSRSFGDYALKTPKLLVSHVPEVSIE
  . .| .||.||  | ..||  .  |..||| . |.||.||.. |  . .  . .|. |            |||||..||. .|   . ..  | || .
qqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsd..nqtrinG............lavsralGdhfikelniGlisepyvsnr

-RIEDKDYFFVIACDGIWDVLSDQEVVDLARKHYGQAQ
  .  .| | ..| ||.|||.| .. ..  .  | | .
illtpfdkflivasdGlwdvisGkdaiekvkslydqqa
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 282-389 5.6e-16 51.9 In-house 77-187 (292) alignment 
Range on Protein: 282-389
Range on HMM: 77-187/292.0
MAIKKKKQGGSTSLTimlnGSSTTNAHLIIANLGDCRAVMCR---GTR--AHRLTQDHKPDRPDEKKRIQQAGGHVV--NVMGVSRVMGAREDREPRQAL
. |.........            .  ||.||.|| ||.. |   |..     |..||||. |||..||..|||.|    | |      ||  |  .|  
ltidaresattavvc....arvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeG

MLAVSRSFGDYALKT
 ||.||. ||. |. 
dlalsralGdfhlfe
subfamily_TAB1_pd Subfamily TAB1 145-423 2.1e-12 39.5 In-house 8-260 (333) alignment 
Range on Protein: 145-423
Range on HMM: 8-260/333.0
SGRKNDNEDRYDVAmSMGALGRLFAVYDGHAGSECADYVKKCLPGNIVGGyrggvvgcegtdaelqELQSQMSEAQQSlVELTAALEATpDDESLQQMQQ
| ... .||.  .. ..     |.||.||. |.. |..|.. |. .....                .|.....||.    .|..|.|.. . . |.....
skedhevedkvflf.ktendpilyavFdGydGnkaakfveqrLvaellle................qltdelaeaevk.evlkrafeev.erkflesidd

QLLAQHEAKSGLSTDYQTAVLKcvKdGYKcTDKNWLSmAIKKKKQGGSTSLTIMLngsstTNAHLIIANLGDCRAVMCR---GTRAHRLTQDHKPDRPDE
 |  ... .| |  . .   |.  .  |. .  . |.  .... .||.| . ...      | .| .|| || ||....    .. . | .||. | .||
alaekddlqsqlPegvssyele..e.qyp.ekierlq.eleeeisgGttAvvali.....fnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedE

KKRIQQAGGHVVNVMGVSRVMGARedrEPRQALMLAVSRSFGDYAL-KT-PKLLVSHVPEVSIE-RIEDKDYFFVIACDGIWDVL
 .|... |  . ..  . |. .     . |.   . |   . |  . ..  .  |   |...    |.|  || |.  ||.   |
llRlkdLGldieqikrnkrlgske...ntRsiGdykvkkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktL
PPM_PTC7_motif 413-435 3.5e-11 36.4 In-house 1-23 (51) alignment 
Range on Protein: 413-435
Range on HMM: 1-23/51.0
VIACDGIWDVLSDQEVVDLARKH
..|.||.||||||||.|||.|..
iLAsDGLWDvlsdqeavdlvrdq
subfamily_PPM1H_pd Subfamily PPM1H 159-351 3.1e-10 32.4 In-house 56-216 (404) alignment 
Range on Protein: 159-351
Range on HMM: 56-216/404.0
MSMGALGRLFAVYDGHAGSECADYVKKCLPGNIVGGYRGGVVGCEGTDAELQELQSQMSeaqqslveltaaleatpddeslqqmQQQLLAQHEAKSGLST
.. ..   .|...||||||  |    |.|   .    .  .     ..|| .| ....|                         ...  ...|  .  . 
eeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteess.........................kespssvseiyeekei

DYQTAVLKCVKDGYKCTDKNWLSMAIKKKKQGGSTSLTIMLngsstTNAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDrpDEKKRIQQAGGH
  .. |.  . . ..  |.       . ...|| | |  ..      .  | .|| ||.||...|  . . | .|. |.   |..|.|. .  
skeeLviGalesaflemDeqiarereayrikGGCtalvalv.....llgklYvanaGDsRailvrkdeiiplsadftPe..teRqRlqelafl
subfamily_PPM1H_pd Subfamily PPM1H 367-438 1.7e-08 26.7 In-house 272-353 (404) alignment 
Range on Protein: 367-438
Range on HMM: 272-353/404.0
DREPRQALMLAVSRSFGDYALKTPK------LLVSHVPEVSIERIED----KDYFFVIACDGIWDVLSDQEVVDLARKHYGQ
 .  |    ..|.| .||. ||. .       ..| ||||..  ...    .|   ..| ||.|||||..||  . |.   .
gkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk
PP2C_SIG_SM00331 276-430 2.3e-08 26.9 In-house 80-176 (217) alignment 
Range on Protein: 276-430
Range on HMM: 80-176/217.0
DknwlsmaikkkKQGGSTSLTIMLNGSSTTNAHLIIANLGDCRAVMCRGTRAHRLTQDhkpdrpdekkriqqagghvvnvmgvsrvmgaredrEPRQALM
            |. ..   |. |    .....| .||.||.| .. |  .    ..|                                    . ..|.
e...........keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd...................................vegaplG

LAVSRSfgdyalktpkllvshvPEVSIERIEDkDYFFVIACDGIWDVLSDQE-----VVD
| ...|                ....   .|  . ..... ||.... |...     . .
lepevs................vdirelelek.gdllllytDGltearsekgfaeerlee
subfamily_PPM1K_pd Subfamily PPM1K 140-187 2.8e-08 26.2 In-house 7-53 (263) alignment 
Range on Protein: 140-187
Range on HMM: 7-53/263.0
GVETWSGRKNDNEDRYDVAMSMGALgRLFAVYDGHAGSECADYVKKCL
|...  |....||||....     |   .||.|||||| .||.| . |
GkdsliGkraenedriklkeldpel.lyvavfdGhaGsaaadfvhdkl
subfamily_PPM1G_pd Subfamily PPM1G 137-191 3.6e-08 25.8 In-house 19-73 (473) alignment 
Range on Protein: 137-191
Range on HMM: 19-73/473.0
VRAGVETWSGRKNDNEDRYDVAMSMGALGRLFAVYDGHAGSECADYVKKCLPGNI
.. |. .  | ....||   . . .     |||||||| |.| | || | ||. .
lsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdll
subfamily_PHLPP_pd Subfamily PHLPP 306-434 2.3e-07 23.0 In-house 104-214 (246) alignment 
Range on Protein: 306-434
Range on HMM: 104-214/246.0
NAHLIIANLGDCRAVMCRGTRAHRLTQDHKPDRPdEKKRIQQAGGHVVNVMGVSRVMGaredreprqalmlaVSRSFGDYALkTPKLLV-SHVPEVSier
   | .|. | . ||..|...  ||.. .. ..  | |||..| . . .   .  |..               .| .| . |  | .|   || ||    
sfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingvie..............strllGytfl.fPvvlPkphvrevl...

IEDKDYFFVIACDGIWDVLSDQEVVDLARK
....| ....  . .|.||| .|.|.  ||
LteqdellivGnkalWevlsideaveavrk
Subfamily Dicty-PPM1L-like 375-434 3.4e-07 22.4 In-house 204-261 (305) alignment 
Range on Protein: 375-434
Range on HMM: 204-261/305.0
MLAVSRSFGDYALKTpklLVSHVPEVSIERIED-KDYFFVIACDGIWDVLSDQEVVDLARK
.| .||| ||  ||    ||   ..  .  ...  | |.|.| ||.|.||| |.||.  ..
llkksrskGdknlke...lviPnndspllvvakanDqflvlatdGlwevlsyqdvveevke
DUF1409 Protein of unknown function (DUF1409) 199-231 9e-07 15.5 Pfam-A 11-43 (51) alignment 
Range on Protein: 199-231
Range on HMM: 11-43/51.0
VVGCEGTDAELQELQSQMSEAQQSLVELTAALE
|| |..  |.|.|.. ...| .. |. | .|.|
VvdCGsIrarLeeinaelaeelakladlpkaiE
Subfamily Dicty-PPM1L-like 142-195 1.5e-06 20.3 In-house 12-66 (305) alignment 
Range on Protein: 142-195
Range on HMM: 12-66/305.0
ETWSGRKNDNEDRYDVAMSMGAL--GRLFAVYDGHAGSECADYVKKCLpGNIVGGY
    . .. .||| .| .|. .     || |.||| |   |.|||| |  .||  |
yvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkkl.veivnky
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 404-445 8.4e-06 18.5 In-house 242-282 (292) alignment 
Range on Protein: 404-445
Range on HMM: 242-282/292.0
RIEDKDYFFVIACDGIWDVLSDQEVVDLARKhYGQAQDGMMT
 ....| |.|.| ||. |||...||| |  | . .| | ..|
eldsddaflvlasdGvldvllnaevvlllak.sqeaadkvit