Gene PPM1D in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP132_AA protein Get Run
MbreP132_AA_96-409 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 99-408 1.7e-111 365.2 In-house 2-308 (309) alignment 
Range on Protein: 99-408
Range on HMM: 2-308/309.0
AIACSSCDHGDRPYMQDFVTQSSAE-------GWAGFALFDGHGGHEAARFASHHVWGYLHRNEDLkvaismLNSPPPDVptsslsahldklgeleeahr
....|..|.|.|.||.|.|.....|       ..|..|.||||||.|||.||..|.|.........      |.|.|.||                    
lsvtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf......lssepedv....................

ivQRALDAAFVDCHKAMHQLYRSWPQRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFyycLGADEP-------QCLTVSHLPNIPSEVRRIRNCGGR
  ..|...||...|.||.. ...||.......|||||||......|..|..|.||||...   ||..||       ..||..| |..|.|..||...||.
..leAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaiv...lgvkepkekklrakeltkdHkPespeekerieelGGe

ISAM----RVCWTRL-SASSGQ--RVSVPFLNMTRALGDFWSWNPASEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCC
..|.    ||.|.|    ..|.  . ..|||...|.|||.||.| .|....|.|.|....| ..|.|..|.|.||||||..|.|..|  ||... .|...
vaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkel

-------PAPALVECALQFTRSHNIKCDNVSVTVVFLR
       .|.|||..|||..||.....|||||.||.|.
keeqsrsvakalvkealqrwrskklraDnvsvivvile
0034914 PP2C-like 99-409 9.9e-52 168.6 In-house 21-292 (295) alignment 
Range on Protein: 99-409
Range on HMM: 21-292/295.0
AIACSSCDHGDRPYMQDFVTQSS-----AEGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDL-------Kvaismlnspppdvptsslsahldklgel
  .....| | |....|.|.         |... |..|||||||.||..||.... .|...                                       
lrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls............................

eeaHRIVQRALDAAFVDCHKAMHQLYRSwpqrrDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYclGADEPQCLTVSHLPNIPSEVRRIRNCGGRIS
      ...||  ||. .......| ..     ...... ||||...| ... |..|||||| |. .    .|...||| | |. ..|..||...||..|
...ledieealrkaflaadeellelall.....rpelagsGtTavvalirgnklyvanvGDSravll..rngelvqltvdhkpvnelererilsaggavs

AMRVCwtrlsassgqrvsvPFLNMTRALGDFWSWNPA---SEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESL---AKNCCPAP
  ||.              ..|..|||||||.  ..     . ..| ..|..... .....|||...|||||||.|.. ..  .||. |         | 
hgrvn..............gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaae

ALVECALQftrshNIKCDNVSVTVVFLRG
.||. ||.     . ..||..| ||.|.|
eLvdlAla.....rgsrDNiTvvvvrlng
PP2Cc_SM00332 97-405 8.9e-45 146.2 In-house 11-274 (274) alignment 
Range on Protein: 97-405
Range on HMM: 11-274/274.0
QHAIacsSCDHGDRPYMQDFVTQSSA----EGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDLKVA-IsmlnspppdvptsslsahldklgeleeaHR
...    |.. | |  |.|.. .       |.|. |..||||||.|.|.|.| ... .|...   |                                . 
sygk...ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel............................ed

IVQRALDAAFVDCHKAMHQLYRSWPQRRdkhySTAGTTATLLLCTRHDLFLANVGDSDAFYYCLGAdePQCLTVSHLPNIPSEVRRIRNCGGrisamrvc
 |..||  ||....... . ..|. ...    ...|.||.. | .. ||..|||||| |. .  |      |.| | |. ..|..||.. ||        
dveealkkaflstdeeileeeqskelen....alsGstavvallkkedlyvanvGDSravlcrngk..avqlsvdhkpedederkRikkagg........

wtrlSASSGqRVSVPfLNMTRALGDFWSW--NPASEAYIVDPHPHTCHRLrqPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNccP-------APAL
    ... | ||.   |...||.||..    ..  | ||.     ....|   .||.|.|.|||||||.| . ..  .||. |||.          |  |
....vvekg.rvngg.lavsrafGdhflkknkklkepyitaepdvkvvtl..tsedeflilaSDGlwdvlsnqevvdivrkllakg..ktndpqeaaell

VECALQFtrshNIKCDNVSVTVV
.|.|..       ..||..| ||
deeairr....ggseDniTvvvv
0049733 PP2C-like 103-408 1.7e-40 131.8 In-house 7-234 (235) alignment 
Range on Protein: 103-408
Range on HMM: 7-234/235.0
SSCDHGD-RPYMQDFVTQssaeGWAGFALFDGHGGHEAARFASHHVWGYLHRNE-DlkvaI---SmlnspppdvptsslsahldklgeleeahriVQRAL
 ..| |  |....|.|      |.. ||..||||||.|...||.... .|..   .        .                              ...||
aasdigrvrkvneDavlv....glllfavaDGhgghaagevasellvetllellle....lllld..............................leeal

DAAFVDCHKAMHQLYRSWPqrrdkHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYClgADEPQCLTVSHLPNIPSEVRRIRNCGGRIsamrvcwtrlsa
 .||  ...|...|....|     .... ||||...| . . |..|||||| |. .    .. ..||. | |. . |..||...||..            
rkaflaaneallelalasp.....elagmgtTavvalldggklyvanvGDsrayllr..dgklvqltedhspvnelerqriitaggav............

ssgqrVSVPFLNMTRALGDFWSWnpaseayivdphPHTCHRLRQPDEddFVIMASDGLWDCLPPATAGVVVREslAKNCCPAPALVECALQftrshNIKC
     .  . | .||||||..              |....   .|..  |...|||||||.|.. ..  ..|.        | .||| ||.     . ..
.....rvpgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelala.....rggr

DNVSVTVVFLR
||..| ||.|.
DNiTvvvvrld
PPM_PTC7 107-379 1.8e-40 132.0 In-house 19-238 (259) alignment 
Range on Protein: 107-379
Range on HMM: 19-238/259.0
HGDRPYMQDFvtqSSAEGWAGFALFDGHGGHEAARFASHHVWgylhrnEDLKVAISMLNSPppdvptsslsahldklgeleeahrIVQRALDAAFVDCHK
|.. . ..     |. . .| || ||||||.|||..|. |..      | || ..|  ..                          ...||  .|  .. 
hialanless...sgkdsvaffavfdghggreaakyarehle......eilkerksfeele........................klekalrksflaldt

AMHQLYrswPQRRDkHYSTAGTTATLLLCTRHDLFLANVGDSDAfYYCLGADEPQCLTVSHLPNIPSEVRRIRNCGGRIS---AMRVCWTrlsassgqrv
...      .. .. . || |.||...| | ..|. |||||| | . | . .. . ||..| |. ..|..||.. ||..|     ||...          
deelks...seant.epstsGstAvvalitgsklyvAnvGDSra.vLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngv..........

svpfLNMTRALGDFWSWNPASEAYIVDPHPHTCHRLRQPDeDDFVIMASDGLWDCLPPATAGVVVRESLAKNccpA
    |...||.|||.. .  .|   | ..|..... .... |.|.|.|||||||.... .|  .||. |.|.   .
....lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk...d
PP2C Protein phosphatase 2C 114-375 3.2e-40 131.3 Pfam-A 26-232 (255) alignment 
Range on Protein: 114-375
Range on HMM: 26-232/255.0
QDFvtqSSAEGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDLKVAIsmlnspppdvptsslsahldklgeleeahrIVQRALDAAFVDcHKAMHQLYr
.     |. . .| || ||||||.|||..|. |... | ...... .                                |..||  .|   . ...    
eks...sgkssvaffavfdghggreaakyarehleeilkeqksflele..............................kvekalrksfla.dtdeelks.

swPQRRDkHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYCLGADEpQCLTVSHLPNIPSEVRRIRNCGGRIS-AMRVCWTrlsassgqrvsvpfLNMTR
  .. .. . |. |.||.. | . ..|..|||||| |     . .. . ||. | |. ..|..||.. ||..|   ||...              |...|
..skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngs..............LavsR

ALGDFWSWNPAseAYIVDPHPHTCHRLRQPDeDDFVIMASDGLWDCLPPATAGVVVRESLAKN
|||||.. .     ..| ..|..... .... |.|.|.|||||||.|.. .|  .||. | |.
alGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskk
PP2C Protein phosphatase 2C 114-375 3.2e-40 131.3 In-house 26-232 (255) alignment 
Range on Protein: 114-375
Range on HMM: 26-232/255.0
QDFvtqSSAEGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDLKVAIsmlnspppdvptsslsahldklgeleeahrIVQRALDAAFVDcHKAMHQLYr
.     |. . .| || ||||||.|||..|. |... | ...... .                                |..||  .|   . ...    
eks...sgkssvaffavfdghggreaakyarehleeilkeqksflele..............................kvekalrksfla.dtdeelks.

swPQRRDkHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYCLGADEpQCLTVSHLPNIPSEVRRIRNCGGRIS-AMRVCWTrlsassgqrvsvpfLNMTR
  .. .. . |. |.||.. | . ..|..|||||| |     . .. . ||. | |. ..|..||.. ||..|   ||...              |...|
..skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngs..............LavsR

ALGDFWSWNPAseAYIVDPHPHTCHRLRQPDeDDFVIMASDGLWDCLPPATAGVVVRESLAKN
|||||.. .     ..| ..|..... .... |.|.|.|||||||.|.. .|  .||. | |.
alGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskk
subfamily_PPM1A_pd Subfamily PPM1A 119-407 7.5e-37 120.2 In-house 36-280 (282) alignment 
Range on Protein: 119-407
Range on HMM: 36-280/282.0
QSSAEGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDLKVaismlnspppdvptsslsahldkLGELEEAHRIVQRALDAAFVDCHKAMHQLYRSWPQR
 .. ..|. ||.||||.|.|.|.....|. . . ..|.||                          . .. .. |. ||  .|.. ..|...| ..  ..
lgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.......................aaleasekdevkealrqgfLaldeairelstdlkta

rDKHystaGTTATLLLCTRHDLFLANVGDSDAFYYCLGadEPQCLTVSHLPNIPSEVRRIRNCGGRISAMRVCWTrlsassgqrvsvpfLNMTRALGDFW
 ||     |.||. .| . . |..||.||| |. .  |  . . ||  | |. |.| .||.. || .   ||. .              | ..|||||. 
.dks....GsTavtvlvsekhliianlGDsRavlcrng..kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGa..............LAvsRalGDye

SWN---PASEAYIVDPHPHTCHRLRQPDEDdFVIMASDGLWDCLPPATAGVVVRESLAKNcCPAPALVECALQFTRsHNIKCDNVSVTVVFL
  .     .|   | ..|..    |. ..| |...|.||.|| |  ...  .||..| ..   . ....  .. .  ..   ||.|| ||..
ykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkal.ekgsrDNlsvlvvlf
subfamily_PPM1G2_pd Subfamily PPM1G2 114-407 7.1e-32 103.5 In-house 41-286 (287) alignment 
Range on Protein: 114-407
Range on HMM: 41-286/287.0
QDFVTQSSAEGWAGFALFDGHGGHEAARFASHHVWGYLHRnedlkvaismlnspppdvptsslsahldkLGELEeaHRIVQRALDAAFVDCHKAMHQLyr
......|  .  | ||.||||||...|..|....  ....                               ...  .  ....|  ||... . . .   
nelleksddkslalfavfDGhGGakvakyagkklikkiak.............................kksfk..egaleqilkdafletDeellkd..

swpqrRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYyCLGADePQCLTVSHLPNIPSEVRRIRNCGGRISAMRVCwtrlsassGQrvsvpfLNMTRA
     .  . ..||.||.  | . ..|. ||.||| |   .  ..  . |.. | |.  || .|| . || ..  ||.        |.      | . ||
.....eklkdesaGstavvvlikeeklyvanaGDsravl.sskgn.vkalsfDhkPqeesekkriiaagGfvelnrvn........gn......Lalsra

LGDFWSWNPA---SEAYIVDPHPHTCHRLRQpDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCPAP---ALV-ECALQFTRSHNIKCDNVSVTVVF
||||   .     .|  ||   |    . .. ..|.|...| ||.||.|  ..   .||| |...  .      |. .|  . ... .. |||..| .| 
lgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv

L
|
l
subfamily_PPM1K_pd Subfamily PPM1K 185-408 2.5e-22 72.3 In-house 59-259 (263) alignment 
Range on Protein: 185-408
Range on HMM: 59-259/263.0
ELEEAHRIVQRALDAAFVDCHKAMHQLYRSwpQRRDKHYSTAGTTATL-LLCTRHDLFLANVGDSDAFYyCLgADEPQCLTVSHLPNIPSEVRRIRNCGG
.| |  . ..  |  || ...|....  .   .  .... ..|||||. ||    .| ||..||| |   |    ....||  | |.   | .||...||
rllekekdleivlknafeeldkklkrylef..svaeaellssGttatvsllrdGtelvlaslGdsrail.cr.nGkakkltrdhdPeleeekerikaagG

RISamrvcWTrlsaSSGQRVSVPFLNMTRALGDFwswnpASEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCcPAPALV
...     |.    |.|.      | |||.|||.         | |   |.| .   . ..| |... .||. . .     . .||     .   | ||.
sve.....wn....slgkplvngrlamtrslGdl.....dlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpee.aahalt

ECALQFTRShnikcDNVSVTVVFLR
|.|||.        ||... || |.
eqalqygse.....dnatavvvplg
subfamily_PPM1E_pd Subfamily PPM1E 203-408 4.5e-21 68.2 In-house 79-263 (265) alignment 
Range on Protein: 203-408
Range on HMM: 79-263/265.0
DCHKAMHQLYRSWPQRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAfyYCLGADEPQCLTVSHLPNIPSEVRRIRNCGGRISAMrVCWtrlsassgqR
  ..|.... ..  |.  .   ..|.||   | ... |..| .|||.|  . .   |   |.  | |. . | .|| . || .  .  .|         |
alkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqa..llvrkgeavqlmkpHkPeredEkkRieeagGlvvvi.gaw.........R

VSvPFLNMTRALGDfwswnPASEAYIVDpHPHTCHrLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCPAPALVECALQFTRSHNiKCDNVSV
|    |...||.||     . ...|..  .. ... ..  ......|.|.||||| ... ..  .|.|.||..      . .  ..  ....   ||..|
vn.GvLsvsRaiGD.....vklkpyvsg.eadvae.veldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeag.ssDnitv

TVVFLR
 |||| 
vvvfld
subfamily_PPM1L_pd Subfamily PPM1L 108-408 5e-20 64.9 In-house 14-267 (269) alignment 
Range on Protein: 108-408
Range on HMM: 14-267/269.0
GDRPYMQDFVT-QS---SAEGWAGFALFDGHGGHEAARFASHHVWGYLHRNE-DLkvaismlnspppdvptsslsahldklgeleEAHRIVQRALDAAFV
| || |.|  . .       |   ||.||||||  || || . .   ....  .|                              .|..  .  .. . .
GrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel..............................dadkentepinfskl

DCHKAMHQLyRSWPQRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYClGADEPQCLTVSHLPNIPSEVRRIRNCGGRISaMRVCWtrlsassgqR
  .. .    .   ..  . . .||||| . | . .|| .||||||    |     .   |.  | |. . | .||.. || |. .| .|         |
ltdeilsvd.ekllekakraediaGttalialvqesdlivanvGdsrGvlyd.krGkaiplsfdhkpqqvkerkrikkaGGfia.frGvw.........r

VSvPFLNMTRALGDFwswnPASEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCPAPALVECAlqFTRShniKCDNVSV
|.   | ..|||||.    |  .  .| ..|       .  . .|.|.|||||||..    |   ..| | .    | .||  .  | |      ||..|
va.GvlatsralGdy....plkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvles..fkrG...svdnitv

TVVFLR
 || |.
lvvklk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 187-405 7e-20 64.4 In-house 56-251 (255) alignment 
Range on Protein: 187-405
Range on HMM: 56-251/255.0
EEAHRIVQRALDAAFVDCHKAMHQLYRSWPQRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFyYCLGADEPQCLTVSHLPNIPSEVRRIRNCGGRIS
|| ..|..  ||.   .  |.... |..   . ...    ||||. .| ...  ..|||||| .   |      . |.. | |. .|| .||.. || . 
eelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvliiedkvyianvGdsrvv.lcqkdgtakrlsldhkPseeseekriselGGtvv

AMrvcwtrlsaSSGQRVSVpFLNMTRALGDFWSwNPaseaYIVdPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCpAPALVECA
.              ||    | ..||||| .  .|    ..| |.|.  . |..  .| |.|.| ||.|| .    |  .| ..   .   |  | . |
st.........vvtsrvnG.tlavsralGdsfl.eP....fvv.pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpeka.aeklrdla

lqFTRShniKCDNVSVTVV
  ...      ||.|| |.
..yssG...stdnisvivi
PPM_PTC7_SpoIIE 120-377 4.3e-18 59.0 In-house 29-214 (230) alignment 
Range on Protein: 120-377
Range on HMM: 29-214/230.0
SSAEGWAGFALFDGHGGHEaaRFASHHVWGYLHRNEDLKVAismlnspppdvptsslsahldklgeleeahrivqraldaafvDCHKAMHQ---------
|    .. .. .|||||..   .|. .... |... .                                              .  ....          
sggrlalvvgdvdGhGgra..alamgllrtalrelafagle..........................................kpeeilrrlnlalaadl

--LyrswpqrrdkhYSTAGTTATLLLCTRHD--LFLANVGDSDAFYYCLGADepqcltvshlpnipsEVRRIrNCGGRIS----AMRVCWTrlsassgqr
               |. |.||...| . ..  | .||.||| .. .  ..                |..||   || .|      || ..         
ede...........psssgaTavvalidpstgklyvanaGdsppllvrddgg...............ereri.vagglpslGilpgrvfgv.........

vsvpfLNMTRALGDFWSWNpasEAYIVDPHPHtCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCC
     |....| ||..      .  .|...|.   . . ...|.|.|.|||||||.|.|. .   ||..| |...
.....lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekpaa
subfamily_KAPP-like_pd Subfamily KAPP-like 221-406 6.1e-15 47.9 In-house 95-265 (266) alignment 
Range on Protein: 221-406
Range on HMM: 95-265/266.0
KHYSTAGTTATLLLC--TRHDLFLA--NVGDSDAFYyCLGaDEPQCLTVSHLPNIPSEVRRIRNCGGRISAMRvcwTRLSassGqrvsvpfLNMTRALGD
|..   |.|||| |     .  .|   ||||| ||  . | .|   |.  |  . |.| .||.. |  .|  .   ||.    |       | ..|||||
kdfeyeGatatlalvwsdGqqrylqvanvGdssafl.srG.neslelskdhkakdpeekqrikddGitlsdnq...trin...G.......lavsralGd

FWSWNpasEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVReSLAKNCCPAPALVECALQFTRSHNIKCDNVSVTVVF
 .  .       .  .|.   |.     |.|.|.||||||| .    |  .|. ||  .   .  . .. |. .       ||||| || 
hfike...lniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvk.slydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PPM1G_pd Subfamily PPM1G 217-407 3.5e-14 45.6 In-house 287-470 (473) alignment 
Range on Protein: 217-407
Range on HMM: 287-470/473.0
QRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDafyyCLGADEPQC--LTVSHLPNIPSEVRRIRNCGGRISA-MRVcwtrlsaSSGqrvsvpfLNMTRA
.....  . .||||.  |   ..|. ||.|||     |  . . .   | . | |. . | .||.. ||..    ||         |       ||. ||
eekeepGedsGttAvvaLlkekklivAnaGDsR....cvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRv.......nGG.......LnlsRA

LGDFWSWNP---ASEAYIVDPHPHTcHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCP-----APALV-ECALQFTRSHNIKCDNVSVTV
|||.   .      .  ..   |   . |   .||.|...|.||.|...        ||. |.|.          .|. .|  . |      ||| .| .
lGDhaYkkneeLplkeqmisAlPDi.kvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtvii

VFL
| |
vll
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 223-406 3.9e-14 45.2 In-house 101-275 (276) alignment 
Range on Protein: 223-406
Range on HMM: 101-275/276.0
YSTAGTTATLLLCTRHD----------LFLANVGDSDAFYyCLGaDEPQCLTVSHLPNIPSEVRRIRNCGGRISAMRvcwTRLSassGqrvsvpfLNMTR
.   |.|||| |  .            |  |||||| ||  . | .|   |.  |  . |.|..||.. |  .|  .   ||.    |       | ..|
feyeGatatlalvwsdGeeqqqqqqrylqvanvGdssafl.srG.neslelskdhkatdpeekqrikddGitlsdnq...trin...G.......lavsr

ALGDFWSWNpasEAYIVDPHPHTCHRLRQPDEDDFVIMASDGLWDCLPPATAGVVVReSLAKNCCPAPALVECALQFTRSHNIKCDNVSVTVVF
|||| .  .       .  .|.   |.     |.|.|.||||||| .    |  .|. ||  .   .  . .. |. .       ||||| || 
alGdhfike...lniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvk.slydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 220-318 4.3e-14 45.7 In-house 79-184 (292) alignment 
Range on Protein: 220-318
Range on HMM: 79-184/292.0
DKHYSTAGTTATLlLCTRHD--LFLANVGDSDAFYY-CLGA--DEPQCLTVSHLPNIPSEVRRIRNCGGRISAMRVC-WTRLSAS--SGQRVSVPFLNMT
 ..   |.|...    .| |  |.||||||| |  . |||.   |.. |. .| |. | | .||.. |||.   ||  |    ..    .|     | ..
idaresattavvc.arvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlals

RALGDFW
|||||| 
ralGdfh
PP2C_SIG_SM00331 125-406 6.9e-12 38.4 In-house 30-216 (217) alignment 
Range on Protein: 125-406
Range on HMM: 30-216/217.0
WAGFALFDGHGGHEAARFASHHVWGYLHRNEDLKvaismlnspppD----VPTSSLSAHLDKlgeleeahrivqraldaafvdchkamhqlyrswpqrrd
   ....||.|.. ||  ||  . . |.   . .           .    ..    .|. ..                                      
rlllvvaDgmGkGlaAaaassqlrtalrellseg...........eelsqalkrlnraiyee......................................

KHYSTAGTTATLLLC--TRHDLFLANVGDSDAFYYClgaDEPQCLTVSHlpnipsevrrirncggrisamrvcwtrlsassgqrvsvpflNMTRALGDFW
|. .  ..|..|.|   ... | .||.|||  . .    |. ..  ...                                         .....||  .
keekgmfaTlllalydfssgklsyanaGdsrpyllr...dgklveilkd.........................................vegaplGlep

SWNpaseayivdphphTCHRLRQPDEDDFVIMASDGLWDCLPPAT-AGVVVRESLAKN-CCPAPALVE----CALQFTRSHNIkCDNVSVTVVF
. .                | .. ...|......|||..   ... |   . | |... ...| .| .    ..|.... .|   |...| ||.
evs.............vdirelelekgdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng.eDdiTvvvvk
subfamily_ILKAP_pd Subfamily ILKAP 197-360 3e-10 32.7 In-house 85-231 (293) alignment 
Range on Protein: 197-360
Range on HMM: 85-231/293.0
LDAAFVDCHKAMHQLYRSWPQRrDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYCLGaDEPQ-----CLTVSHLPNIPSEVRRIRNCGGRISAMRVc
.  ..|| .|.  . . .  .. .|     |.|||..|     |. ||.||| |. .    .|..     .||. | |    | .||. .|| .   || 
ikkclvdsfkktdeefLklask.akPvWkdGstatvvlvldnvlyvanlGdskavlvrkk.eegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrv.

wtrlsasSGqrvsvpFLNMTRALGDFWsWnpASEAYIVDPHPHTChrlRQPDEDDFVIMASDGLWDCLP
        |       |...|..||   .   .   |  |. . |   .  . | ||..| ||||. . 
.......lG......vlevsrsiGdgr.f..krlGvistPdvkkc...eLtendlfvvlaCdGLwkvfs
subfamily_PPM1H_pd Subfamily PPM1H 125-253 5.6e-10 31.5 In-house 62-189 (404) alignment 
Range on Protein: 125-253
Range on HMM: 62-189/404.0
WAGFALFDGHGGHEAARFASHHVWGYLHRNedLKVAISMLNSPPPDVP---TSSLSAHLDKLGEL-----EEAHRIVQRALDAAFVDCHKAMHQlyrswp
 | |.|||||.|. ||  ||. .   |...  |.  . .| .  .. .    .| . .  .  |       .. ..|  ||. ||... . ...      
layfglfDGhaGsgaalvaskllhkhlkek..ledvlellleksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqiar......

qRRDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYY
  |...  . | ||   |.    |..|| ||| |   
.ereayrikGGCtalvalvllgklYvanaGDsRailv
subfamily_PPM1E_pd Subfamily PPM1E 122-157 3.9e-08 25.8 In-house 37-72 (265) alignment 
Range on Protein: 122-157
Range on HMM: 37-72/265.0
AEGWAGFALFDGHGGHEAARFASHHVWGYLHRNEDL
..  | || ||||||.|||..|..|..  | |.|.|
ekeraffavfDGHgGveaakyaaahlhellvrqekl
subfamily_PDP_pd Subfamily PDP 128-280 6e-08 25.2 In-house 28-209 (398) alignment 
Range on Protein: 128-280
Range on HMM: 28-209/398.0
FALFDGHGGHEAARFASHHVWGYLHRNE----DLKVA-------------ISMLNSPPPDVPTSSLSAHLDKLGE-----LEEAHRIVQRALDAAFVDCH
|..||||||. .|.  |..   |.  .     .|. |             ... ...   |  .. . .|..| .     ||   . |..||  || .. 
fgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslselskylqelleaevekvkealkkaFlklD

KAM-HQLYRSWPQRRDKH---YSTAGTTATLLLCTRHDLFLANVGDSDAFYYCL---GADEPQCLTVSHLPNIPSEVRRIRN
| . ..  .. ...  ..    ...|..|.| |   ..|..||.||. |        |. |   |.  .  . ..||.||..
kdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikk
subfamily_PP2D1_pd Subfamily PP2D1 239-360 9.5e-08 24.2 In-house 189-294 (492) alignment 
Range on Protein: 239-360
Range on HMM: 189-294/492.0
DLFLANVGDSDAFYyCLGaDEPQCLTVSHLPNIPSEVRRIRNCGGRISAMRVCwtrlSASSGQrvsvpfLNMTRALGDFWSWNpASEAYIVDPHpHTCHR
 |..||.|.  |   | .  .  .||  | |. . | .|... |. ...   .    .   |.      |. || || .   .   .. |..|.  |.  
vlyianaGnvqAvL.cre.GkaiiLtreHtprnkkERtRvekagsvvvksekn....glvnGi......ldttRGLGnyGdpk.LkksvipePk.ttsvk

LRQpdEDDFVIMASDGLWDCLP
| .  .. |...|| |||. | 
lde..aaqflvlAsnGlWevls
PP2C_2 Protein phosphatase 2C 114-357 1.2e-07 24.3 Pfam-A 13-179 (212) alignment 
Range on Protein: 114-357
Range on HMM: 13-179/212.0
QDFVTQSSAEGWAGFALFDGHGGHEA----ARFASHHVWGYLHRNEdlkvaismlnspppdvptsslS-----AhldklgeleeahrivqraLDAAFVDC
|| .. ..|...  .|  ||.| ..     ||.| . .  .| ..                      .     .                   .|.....
qDalaireasdgwllaVADGaGsakrSdkGarlaveaagealekll.....................eeeseqe..................eeallrqi

HKAMHQLYRSWPQR--RDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYClGADEPQCLTVSHLPNIPSEVRRIRNCGGRISAmrvcwtrlsassgqr
....... . . ..  ...  .  .|| .|...| . ......||......  ...| |.|. ..   . .|.....      .                
eneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrd.rdgevqllgepdsgeyanettfltsedaeeel...............

vsvpflnmtralgdfwswnpaseayivdphphtchRLRQ-P-DEDDFVIMASDGLWD
                                   |.|. . .. | ... .||..|
...................................rirrlklepgdalllmTDGvsd
PP2C_2 Protein phosphatase 2C 114-357 1.2e-07 24.3 In-house 13-179 (212) alignment 
Range on Protein: 114-357
Range on HMM: 13-179/212.0
QDFVTQSSAEGWAGFALFDGHGGHEA----ARFASHHVWGYLHRNEdlkvaismlnspppdvptsslS-----AhldklgeleeahrivqraLDAAFVDC
|| .. ..|...  .|  ||.| ..     ||.| . .  .| ..                      .     .                   .|.....
qDalaireasdgwllaVADGaGsakrSdkGarlaveaagealekll.....................eeeseqe..................eeallrqi

HKAMHQLYRSWPQR--RDKHYSTAGTTATLLLCTRHDLFLANVGDSDAFYYClGADEPQCLTVSHLPNIPSEVRRIRNCGGRISAmrvcwtrlsassgqr
....... . . ..  ...  .  .|| .|...| . ......||......  ...| |.|. ..   . .|.....      .                
eneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrd.rdgevqllgepdsgeyanettfltsedaeeel...............

vsvpflnmtralgdfwswnpaseayivdphphtchRLRQ-P-DEDDFVIMASDGLWD
                                   |.|. . .. | ... .||..|
...................................rirrlklepgdalllmTDGvsd
subfamily_TAB1_pd Subfamily TAB1 226-363 1.2e-07 23.9 In-house 129-264 (333) alignment 
Range on Protein: 226-363
Range on HMM: 129-264/333.0
AGTTATLLLCTRHDLFLANVGDSDAFYYC-LGADEPQCLTVSHLPNIPSEVRRIRNCGgrISAMRVCWTRLSASSGQRVSVPFLNMTRALGDFWSWNPAS
 |||| . |    .|. |||||| |        .. . | | |  . . |. |... |  . . ..   .. .|  .  |.  ....    |.     |.
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvkkgykdvdilssak

EA-YIVDPHPHTCHRLrqPDEDDFVIMASDGLWDCLPPAT
.   | .|. .  . .   |   |... |||.  .|  .|
gePviaePdiqgaypi..ddityflvlmSdGvyktLeevt
subfamily_PPM1G_pd Subfamily PPM1G 100-155 3.5e-07 22.6 In-house 20-77 (473) alignment 
Range on Protein: 100-155
Range on HMM: 20-77/473.0
IACSSCDHGDRPYMQDFVTQ--SSAEGWAGFALFDGHGGHEAARFASHHVWGYLHRNE
  . | . |.|  . |  .      | .. || .|||||.| |.. .... . |. ..
sygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqk
PPM_PTC7_motif 349-374 1.3e-06 21.8 In-house 1-26 (51) alignment 
Range on Protein: 349-374
Range on HMM: 1-26/51.0
IMASDGLWDCLPPATAGVVVRESLAK
|.|||||||.|.. .|  .||. |.|
iLAsDGLWDvlsdqeavdlvrdqlsk
subfamily_PDP_pd Subfamily PDP 342-380 2e-06 20.2 In-house 282-320 (398) alignment 
Range on Protein: 342-380
Range on HMM: 282-320/398.0
PDEDDFVIMASDGLWDCLPPATAGVVVRESLAKNCCPAP
  .| |...|.|||||.| . ..  .| | |||.   .|
rendkFLvlatDGLwdllsneevvslVgehlakkkekep
subfamily_PPM1H_pd Subfamily PPM1H 342-375 2.4e-06 19.6 In-house 321-354 (404) alignment 
Range on Protein: 342-375
Range on HMM: 321-354/404.0
PDEDDFVIMASDGLWDCLPPATAGVVVRESLAKN
 .||| .|.|.||||| |   ... .||| |.|.
sleDdvlilatDGLWdvlsneevaeivrevlskv