Gene PPM1E in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP133_AA protein Get Run
MbreP133_AA_109-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 110-335 9.3e-107 349.1 In-house 3-221 (265) alignment 
Range on Protein: 110-335
Range on HMM: 3-221/265.0
RYNIDIFTSRGRRHTMEDRHLAIEDLNALLGIkaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLKKS
 |...|.. ...|..|||||.|.||||.|...       .|......|||.||||||||||.|.|.||.....|...|.||..||...| ..|..||.|.
eyevsiaavknkrrkmEDrhvaledlnelfel.......kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqka

ERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQWVIGKPDIAEF
||..|..|.|||.||.....||||||||||....|.||.|.||.||||||||||.||....|.||..|||||||||||||||||.|||..|.|..|.||.
ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaev

DITDDCEYLIAGCDGLWDVMNTETVR
......||||..|||||||.|.|.| 
eldgseeylilacDGlwDvvneeevv
PP2C Protein phosphatase 2C 117-334 1.4e-62 204.6 Pfam-A 7-221 (255) alignment 
Range on Protein: 117-334
Range on HMM: 7-221/255.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA-CDKMFLKKSER-D
. .|.|..|||.|.|...|..           ..  . . |||.||||| ||||.|. .|.....||..|...    ||| ..|||  |... .....  
elqgarksmedahialknleks..........sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWygAWRVNGVLSVSRAIGDRKLKQ----WVIGKPDIA
 ...|.|||..|.|| |||||..|||.. .||... . .|.. |||..|||..|| ...| | .   .||||.|.||||.|| .||.    .|. .||. 
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvt

EFDITDDCEYLIAGCDGLWDVMNTETV
....|.. |.|| ..||||||.. ...
svklteedefliLasdGlwdvlsdqea
PP2C Protein phosphatase 2C 117-334 1.4e-62 204.6 In-house 7-221 (255) alignment 
Range on Protein: 117-334
Range on HMM: 7-221/255.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA-CDKMFLKKSER-D
. .|.|..|||.|.|...|..           ..  . . |||.||||| ||||.|. .|.....||..|...    ||| ..|||  |... .....  
elqgarksmedahialknleks..........sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWygAWRVNGVLSVSRAIGDRKLKQ----WVIGKPDIA
 ...|.|||..|.|| |||||..|||.. .||... . .|.. |||..|||..|| ...| | .   .||||.|.||||.|| .||.    .|. .||. 
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvt

EFDITDDCEYLIAGCDGLWDVMNTETV
....|.. |.|| ..||||||.. ...
svklteedefliLasdGlwdvlsdqea
PPM_PTC7 116-334 2.3e-62 203.8 In-house 6-226 (259) alignment 
Range on Protein: 116-334
Range on HMM: 6-226/259.0
FTSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA--CDKMFLKKSER
   .|.|..|||.|.|  .|..           ..  . . ||| ||||| ||||.|. .|.....|...|...  . ||| ..|||   |... .....
safqgfrksmedahialanless..........sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelkssean

-DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQ------WVIGK
   .|.|.|||..|..| |||||..|||.. .||.|. | .| . |||..|||..|| .. | | . | .|||||| ||||.|| .||.      .|.  
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae

PDIAEFDITDDCEYLIAGCDGLWDVMNTETV
||| . .|... |.|| ..||||||.. ...
PdisstkideedefliLasdGlwdvvsdqea
0034914 PP2C-like 110-334 9.3e-61 198.2 In-house 20-249 (295) alignment 
Range on Protein: 110-334
Range on HMM: 20-249/295.0
RYNIDIFTSRGRRHTMEDRHLAIEdlnallgikaswPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAE--------QPTFKDDPVKALHDGFLAC
.... ... .|||...||..|..             . .........|.| ||||| .||..|.  |.. ..|         ... .|...||...|||.
llrvgvasdqGrrksneDavlvvl............nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaa

DKMFLKKSER--DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygaWRVNGVLSVSRAIGDRKLK--
|. .|.....  . ...|.|||..|.||.|||||..|||.. ..||||.| | . ||| .|.|..|| ...|.|..   .|||||| |.||.||. ||  
deellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlkll

-------QWVIGKPDIAEFDIT-DDCEYLIAGCDGLWDVMNTETV
       ..|.  ||.  ...| .|...|. ..||||||.. |..
lslllleplvsaePdvtvleltledddfllLasDGlwdvlsneei
PP2Cc_SM00332 116-334 1.1e-58 191.8 In-house 15-232 (274) alignment 
Range on Protein: 116-334
Range on HMM: 15-232/274.0
FTSRGRRHTMEDRHLAIEDLNallgikaswpavnDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD-----PVKALHDGFLACDKMFLKKSE
 .. |.|..|||.|  . ||.                  . |.| ||||| |.|||....|.. ..|.. .|.|     . .||...||..|. .|.. .
ssmqgwrksmeDahvvvvdlv.............eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

RDAL---TCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYgawRVNGVLSVSRAIGDRKLK-------QWV
.  |   ..|.|||..|... .||||..|||.. .||||..| | . ||||.|||..|| .. ||| .    ||||.|.||||.||..||       . .
skelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyi

IGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
. .||.   ..|.. | ||  .||||||.. ..|
taepdvkvvtltsedeflilaSDGlwdvlsnqev
subfamily_PPM1G2_pd Subfamily PPM1G2 114-334 2.7e-51 167.2 In-house 22-239 (287) alignment 
Range on Protein: 114-334
Range on HMM: 22-239/287.0
DIFTSRGRRHTMEDRHLAIEDlnallgikasWPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVK-ALHDGFLACDKMFLKKSERD
   . .| | .||| |.  ..            . .| .  . |||.||||| ..||.|  .|.|.||....||.. .. .|.|.||..|. .||... .
gssamqGyrlnmeDahilene..........lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklk

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVwygAWRVNGVLSVSRAIGDRKLKQ---------WVIGK
  ..|.|||.||.. .|||||  |||.  .. .|.. .|   |||..|.||.|| ...|.|      ||||.|..|||.|| . |.          |   
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtav

PDIAEFDITDDCEYLIAGCDGLWDVMNTETV
||.   ....| |.|.  |||.|||.. ..|
PDvlvkkldeddeflvLaCDGiWDvltnkev
subfamily_PPM1A_pd Subfamily PPM1A 111-334 4.8e-51 166.7 In-house 12-239 (282) alignment 
Range on Protein: 111-334
Range on HMM: 12-239/282.0
YNIDIFTSRGRRHTMEDRHLAIEDLNALlgikaswpavndmPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTF---------KDDPVKALHDGFLAC
. . . . .|.| .|||.| .. .|.||             . .|.|||.|||.| |.||... .|.. | |. ..         ||.  .||..|||| 
lrygvssmqgwrvemEDahtvvaslgal.............kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLal

DKMFLKKSERDA--LTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVwygAWRVNGVLSVSRAIGDRKLKQ-
|.   ..|..    . .|.|||||||. ..|..| ||||   .||||... | . |||.|..||.|| .  | ||     |||| | ||||.|| ..|. 
deairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykee

--------WVIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
         |...|... ...... ..|.  |||.|||.. |.|
eekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeev
0049733 PP2C-like 111-334 1.3e-46 151.8 In-house 3-197 (235) alignment 
Range on Protein: 111-334
Range on HMM: 3-197/235.0
YNIDIFTSRGR-RHTMEDRHLAiedlnallgikaswpavndmpPQSWFAVMDGHGGVEAAKFAQAQLHKVIAE--QPTFKDDPVKALHDGFLACDKMFLK
...  .. .|| |...||..|.                      ...||| ||||| .|...|  .|.....|  ....  |...||.. |||.....|.
lsvgaasdigrvrkvneDavlv.....................glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle

KSER--DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVvwygawRVNGVLSVSRAIGDRKLKqwvigkPD
....  .  ..|.|||..|..|.|||||..||| . ..|.|..| |  .|.| .|.|.||| . .|.|      ||.|.| ..||.||. ||      ||
lalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pd

IAEFDITDDCeYLIAGCDGLWDVMNTETV
. ........ .|.  .||||||.. |..
vtvlelepgd.flllasDGlwdvlsdeei
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 108-332 4.1e-45 147.0 In-house 3-214 (255) alignment 
Range on Protein: 108-332
Range on HMM: 3-214/255.0
GRRYNIDIFTSRGRRHTMEDRHLAiedlnallgikasWPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD-PVKALHDGFLACDKMFl
..|...      ||| ||||.  .             . . .| . . ..|..||||| .|||||  .|.|..||    ..  |||.|.. . . . .. 
ssrfkvgfsdmiGrrptmedelvi.............yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi.

kkSERDaLTCGATAVTVLVRGRKLYVAWLGDSQVAMC-RNGEMVTLMNPHKPEREDEKQRIADNEGVVVWY-GAWRVNGVLSVSRAIGDRKLKQWVIGKP
  |||    .|.||..||. . | |.| .|||.| .| ..|  . |   |||  |.|..||..  | ||    . |||| |.||||.||  |. .|. .|
..serp.kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdP

DIA-EFDITDDCEYLIAGCDGLWDVMNTE
|.  ...|. . ..||  |||.||..  |
dlsqsleiskkdkflilacdGiwdlisde
subfamily_PPM1L_pd Subfamily PPM1L 111-334 2e-41 135.1 In-house 5-229 (269) alignment 
Range on Protein: 111-334
Range on HMM: 5-229/269.0
YNIDIFTSRGRRHTMEDRHLAIEDLNallgikaswpavnDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQP----TFKDDPV-----KALHDGFLAC
 .. ... .|||  ||||    ||..             .   .| |||.|||||  ||.||.  | | | ..     . |.. .     | | |  |. 
qqvavysvlGrrprmedrfeieedik.............nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsv

DKMFLKKSERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMC-RNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLK--Q
|. .|.| .|   . |.||.  ||....| || .|||.  .. ..|. . |   |||..  |..|| .  | . . |.|||.|||..|||.||  ||  .
dekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn

WVIGKPDIAEFDITD-DCEYLIAGCDGLWDVMNT-ETV
 || .|||  ||. | . |.||  .||||| .   |.|
lviadpdiltfdlddhkpeflilasdGlwdtfsneeav
subfamily_ILKAP_pd Subfamily ILKAP 118-334 2e-40 131.8 In-house 12-235 (293) alignment 
Range on Protein: 118-334
Range on HMM: 12-235/293.0
SRGRRHTMEDRHLAIEDLNALLGIKASwpAVNDMppqSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPV------KALHDGFLACDKMFLKKSER
 .| |..|.| |. .|||.  |. . |   |. .   |..|| |||.|  |..||. .|||.| |. . .|         |.| | | . |. |||....
rkGereemqdahviledldeqlrleks..lvsrv...syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask

D--ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGE------MVTLMNPHKPEREDEKQRIADNeGVVVWYGawRVNGVLSVSRAIGDRKLKQW-VIG
.  .   |.||..|||    |||| ||||.  ..|. |      .|.|   |.| ...|..||    | ||. |  ||.||| |||.||| . |.  || 
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqka.Ggvvrdg..rvlGvlevsrsiGdgrfkrlGvis

KPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
.||.   ..|..  ...  |||||.|.... |
tPdvkkceLtendlfvvlaCdGLwkvfsadev
subfamily_PPM1K_pd Subfamily PPM1K 155-333 1.7e-35 115.4 In-house 32-220 (263) alignment 
Range on Protein: 155-333
Range on HMM: 32-220/263.0
SWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLK-----KSERDALTCGATAVTVLVR-GRKLYVAWLGDSQVAMCRNGEM
 ..|| |||.|. ||.|.  .|.|.. .     .|  . |.. |. .|| . .      .|.. |. |.||  .|.| | .| .| ||||.  .||||. 
lyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGka

VTLMNPHKPEREDEKQRIADNEGVVVWY--GAWRVNGVLSVSRAIGDRKLKQW-VIGKPDIAEFDI-TDDCEYLIAGCDGLWDVMNTET
  | . |.||.|.||.||   .| | |   |  .|||.|...|..|| .||.. || .|.  ....  ..  .|.   ||. .|.| . 
kkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe
PPM_PTC7_SpoIIE 117-332 1.8e-31 102.7 In-house 7-199 (230) alignment 
Range on Protein: 117-332
Range on HMM: 7-199/230.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEaaKFAQAQLHKVIAEQPtFKDD--PVKALHDGFLACDKMFLKKserdAL
  .|.|..|||.| .  ....           ..      ... ||||| .  ..| ..|.....|.  |..   | ..|....||... . ..      
aaqgarksmedahispanseks..........sggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....ps

TCGATAVTVLVRGRK--LYVAWLGDSQVAMCRN-GEmvtlmnphkperedEKQRIaDNEGVV-VWYGAWRVNGVLSVSRAIGDRKLKQ---WVIGKPDiA
..||||| .|... .  ||||..||| . ..|. |               |. || .  | . .  . .||.|||.||.|.||. |.     |  .||  
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.t

EFDITDD-CEYLIAGCDGLWDVMNTE
. .....  |.||...||||||.. .
sdgelfgkdeflilasdglwdvlspq
subfamily_PPM1D_pd Subfamily PPM1D 115-334 6.9e-30 97.2 In-house 6-257 (309) alignment 
Range on Protein: 115-334
Range on HMM: 6-257/309.0
IFTSRGRRHTMEDRHLAIEDL-NALLGIkaswpavndmpPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDP----VKALHDGFLACDKMFLKK-
 ....| |. |||.     .  . .. .            .. .||.||||| ||||||. .| .|| .|  |  ..    ..|....|||. .   || 
seadqGgrkymeDvvaivleeeesaeel...........evafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkl

------SERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGE------MVTLMNPHKPEREDEKQRIADNEGVV---------VWYG-AWRVNGV--
       . .  | |.|| .|..|..|||||  |||.. .  . .        .|.. ||||  .||.||..  | |         ||     . ||   
eeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptv

------LSVSRAIGD-----RKLKQWVI-GKPDIAEFDITDDCE-YLIAGCDGLWDVMNTETV
      |.|.|..||      | ...|.  .||. .. .. . | ..| . ||||.|...|..
ideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpeda
subfamily_PPM1G_pd Subfamily PPM1G 209-334 4.7e-28 91.4 In-house 289-421 (473) alignment 
Range on Protein: 209-334
Range on HMM: 289-421/473.0
SERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGawRVNGVLSVSRAIGDRKLK---------QW
.|      |.||| .|....||.||  |||   ..|||. . |   |||| | |..||    | |   |  |||| | .|||.||   |         | 
keepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqm

VIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
.   |||    .|.. |.|.  |||.|.||. . |
isAlPDikvltlteedeFlvlAcDGiWnvmesqev
subfamily_KAPP-like_pd Subfamily KAPP-like 155-332 1.6e-23 76.1 In-house 35-222 (266) alignment 
Range on Protein: 155-332
Range on HMM: 35-222/266.0
SWFAVMDGHGGVEAAKFAQAQLHKVIAEQP--TFKDDPVKALHDGFLACDKMFL------KKSERDalTCGATAVTVLVRGRKLY--VAWLGDSQVAMCR
. |||.||| |  ||. |.  . |.. ..   | .||  .  .|     ...|       |. | .   . || . |   |.. |  || .|||   ..|
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye..GatatlalvwsdGqqrylqvanvGdssaflsr

NGEMVTLMNPHKPEREDEKQRIAdNEGVVVWYGAWRVNGVlSVSRAIGDRKLKQWV---IGKPDIA-EFDITDDCEYLIAGCDGLWDVMNTE
  | . |   || . ..|||||  ..|. .  .  |.||.  ||||.||  .|.     |..| .. .. .|   ..||   ||||||.. .
Gneslelskdhkakdpeekqrik.ddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 157-327 1.2e-20 67.3 In-house 24-213 (292) alignment 
Range on Protein: 157-327
Range on HMM: 24-213/292.0
FAVMDGHG--GVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMfLKKSERDALTCGATA-VTVLVR-GRKLYVAWLGDSQVAMCR-----NGE
 ||.||||  | . |..|. .| . . |    . .  .||  . |      |.|.  ||   ..|| |   || .|.|..| .|||.. . |     . |
aavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaak.ldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye

MVTLMNPHKPEREDEKQRIADNEGVVV--------WYGAWRV------NGVLSVSRAIGDRKLKQ-WVIGKPDIaefDITDDCEYLIAGcDGLWD
.. | . ||||  ||..||    | |         . |. ||      .| |..|||.||  |..  |. .|..   .|    .||  |  ||| 
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel...qihagrqylgrg.pglwt
subfamily_PP2D1_pd Subfamily PP2D1 229-334 3.1e-20 65.3 In-house 189-298 (492) alignment 
Range on Protein: 229-334
Range on HMM: 189-298/492.0
KLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGA-WRVNGVLSVSRA---IGDRKLKQWVIGKPDIAEFDITDDCEYLIAGCDG
 ||.|  |. |  .||.|....|   | |. . |..|.  . .|||  .   .|||.|.. |    .|| |||. || .| .    ... . .|.    |
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

LWDVMNTETV
||.|.. | |
lWevlseeev
subfamily_PHLPP_pd Subfamily PHLPP 154-333 2.3e-19 62.3 In-house 27-207 (246) alignment 
Range on Protein: 154-333
Range on HMM: 27-207/246.0
QSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLKKSERdaltCGATAVTVLVRGRK--------LYVAWLGDSQVAMCRN
.. . ..||.  .| ..  |  ...|..|. . . .  . ..  .|.. .   .. |.     |..|. .|.|  |        | ||  |  | ...||
ealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGek....lgsaallilirhdkvdPaksfsLevAsvGtlqavliRn

GEMVTLMNPHKPEREdEKQRIADNEGVVVWYGawRVNGVLSVSRAIGDRKLKQWVIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTET
|. ..| .... |.. | .|| ......   .  ..|||.. .| .|   |  .|. || . |  .|.. |.|| | . ||.|.. . 
gkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlside
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 155-332 2.8e-19 62.1 In-house 34-232 (276) alignment 
Range on Protein: 155-332
Range on HMM: 34-232/276.0
SWFAVMDGHGGVEAAKFAQA----QLHKVIAE---QPTFKDDPVKALHDGFLACDKMFLK----KSERDALTCGATAVTVLVRG--------RKLYVAWL
. |||.||| |  ||. |.     .| |..       | .||  .  .|      ..| .     .. .   . || . |   |        | | || .
alfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvanv

GDSQVAMCRNGEMVTLMNPHKPEREDEKQRIAdNEGVVVWYGAWRVNGVlSVSRAIGDRKLKQWV---IGKPDIA-EFDITDDCEYLIAGCDGLWDVMNT
|||   ..|  | . |   || .  .|||||  ..|. .  .  |.||.  ||||.||  .|.     |..| .. .. .|   ..||   ||||||.. 
GdssaflsrGneslelskdhkatdpeekqrik.ddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisG

E
.
k
Subfamily Dicty-PPM1L-like 153-333 1.9e-14 46.2 In-house 36-254 (305) alignment 
Range on Protein: 153-333
Range on HMM: 36-254/305.0
PQSWFAVMDGHGGVEAAKFAQAQLHKVI------------AEQPTFKDDPVKALHDGFLACDKMFLKKSERDALTCGATA----VTVLVRGRKLYVAWLG
 .| | |.|||.|  ||.... .| ...            |.    .| |..|.....|. || .|. .| |    |.|      .| .   .. |.  .
elslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilerertivstas

DSQVAMCRNGEMVTLMNPHKPE---------------------REDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQWVIGKPDIAEFDIT--D
|..|...  .    |   . |                      ..... ||   .. .. ||  .||..|..|| .||. ||. || ..|   . ..  .
dtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakan

DCEYLIAgCDGLWDVMNTET
|  ...|  ||||.|.. . 
Dqflvla.tdGlwevlsyqd
subfamily_PPM1G_pd Subfamily PPM1G 117-208 3.1e-12 39.3 In-house 25-102 (473) alignment 
Range on Protein: 117-208
Range on HMM: 25-102/473.0
TSRGRRHTMEDRHLAIEDLNAllgikaSWpavndmppqSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPV-KALHDGFLACDKMFLKK
.  | |. .|| | .| ||.        .         | ||| ||||| | ||.  ..| ... .| ..|.. | |||.. |||.|.   ..
amqGwrvsqEDahncitdlde......dt.........slfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkae
subfamily_PPM1H_pd Subfamily PPM1H 192-266 2.2e-10 32.9 In-house 138-210 (404) alignment 
Range on Protein: 192-266
Range on HMM: 138-210/404.0
KALHDGFLACDKMFLKKSERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREdeKQRI
 || . || .|..  .  |.  .. | ||. .||   |||||  |||.  ..|..|.. | . . || |  .||.
GalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPete..RqRl
PP2C_SIG_SM00331 154-333 2e-09 30.3 In-house 30-168 (217) alignment 
Range on Protein: 154-333
Range on HMM: 30-168/217.0
QSWFAVMDGHG-GVEAAKFAqAQLHKVIAEQPTFKddpvKALHDGFLACDKMFLKKSERDALtcGATAVTV--LVRGRKLYVAWLGDSQVAMCRNGEMVT
.  ..| ||.| |..|| .. .||.... |. . .    ..| . . .... . ...| .    .||..      ...||..| .||| . . |.|..|.
rlllvvaDgmGkGlaAaaas.sqlrtalrellseg....eelsqalkrlnraiyeekeekgm..faTlllalydfssgklsyanaGdsrpyllrdgklve

LMNPhkperedekqriadnegvvvwygawrvngvlSVSRAIGDRKLKQwvigkPDIAEFDITDDCEYLIAgCDGLWDVMNTET
                                     ....|  .  .     .||.|...  .. .|..  |||........
ilkd...............................vegaplGlepevs.....vdirelelekgdlllly.tDGltearsekg
subfamily_TAB1_pd Subfamily TAB1 213-297 7.3e-08 24.6 In-house 126-213 (333) alignment 
Range on Protein: 213-297
Range on HMM: 126-213/333.0
ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCR---NGEMVTLMNPHKPEREDEKQRIADNeGV-VVWYGAWRVNGVLSVSRAIGDRKLK
 .. |.||| .|.   |||||  |||.  ...   . ... |   |. . ||| .|..|  |. .      .. |     |.||| |.|
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdL.GldieqikrnkrlgskentRsiGdykvk
PP2C_2 Protein phosphatase 2C 155-329 1.5e-07 23.9 Pfam-A 25-181 (212) alignment 
Range on Protein: 155-329
Range on HMM: 25-181/212.0
SWFAVMDGHGGVE----AAKFAQ----AQLHKVIAEQPTF-KDDPVKALHDGFLACDKMFLK--KSERDALTCGATAVTVLVRGRKLYVAWLGDSQVA-M
...|| ||.|  .    .|..|      .| | ..|. .  ... ..... . ||  | . .  ... ..   ..| . .............||. .. .
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

CRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygawrvngvlsvsraigdrklkqwvigkpDIAEFDiTDDCEYLIAGCDGLWDVM
 |.||.  |  |.. | . | ... ...    .                             .| ... ... . |.   ||..| .
drdgevqllgepdsgeyanettfltsedaeeel.............................rirrlk.lepgdalllmTDGvsdsl
PP2C_2 Protein phosphatase 2C 155-329 1.5e-07 23.9 In-house 25-181 (212) alignment 
Range on Protein: 155-329
Range on HMM: 25-181/212.0
SWFAVMDGHGGVE----AAKFAQ----AQLHKVIAEQPTF-KDDPVKALHDGFLACDKMFLK--KSERDALTCGATAVTVLVRGRKLYVAWLGDSQVA-M
...|| ||.|  .    .|..|      .| | ..|. .  ... ..... . ||  | . .  ... ..   ..| . .............||. .. .
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

CRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygawrvngvlsvsraigdrklkqwvigkpDIAEFDiTDDCEYLIAGCDGLWDVM
 |.||.  |  |.. | . | ... ...    .                             .| ... ... . |.   ||..| .
drdgevqllgepdsgeyanettfltsedaeeel.............................rirrlk.lepgdalllmTDGvsdsl
subfamily_PDP_pd Subfamily PDP 213-297 1.6e-07 23.7 In-house 149-241 (398) alignment 
Range on Protein: 213-297
Range on HMM: 149-241/398.0
ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNG-----EMVTLMNPHKPEREDEKQRIADN----EG-VVVWYGawRVNGVLSVSRAIGDRKLK
. . ||.|...|..|..|.||  ||..  ....      |.|.| . .  . |.| .||  .    |   |.  |  |. | |  .|| || ..|
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirng..RlLgeLqPlRAFGdvryK