Gene PPM1G in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP134_AA protein Get Run
MbreP134_AA_20-488 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-488 3.8e-186 612.7 In-house 1-472 (473) alignment
Range on Protein: 4-488
Range on HMM: 1-472/473.0
FLEKPITDKEFEEGAdRFGHKFCVGSMQGWRADQEDAHLAIPDIDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVTQALQKAFL
.|.||...|| |... . ........|||||..||||| .|.|.||......|.|||||       ||.|.||..|.|.||||.|...|.|..||..|||
ylskpkvekesedes.neelsygasamqGwrvsqEDahncitdldedtslfavyDGHGG......kevakyvakklpdllkaqkgykegdvekaleeafl

ALDLQIKAEESLAELQQLAHAGNDSDDDdndSEDDEEDGDNIEALQADADIPIDELKRANgkradnagetatDGQLDQKRAKLQALLTGDLMEDDEDDDE
||| ..||||||.||...|.|..|.|..   .||||||.|.||.|...|.||.|||....            ||. ..|....||||.|...||.||.||
alDeklkaeeslkelkeiaeaeededee...eeddeededeiellteeaeipldellkrl............dgdgsekeelsqallegaasedeedede

DDEDDDDEDDNEEEAKDKDSKQKQSKDGKQSTKEGDDQDQAAD---------------------DSDEDEEGVEEQAFEHSESIRAQLLAALAQHGEGSE
|.|....|.|.|||.|....|.|..|.|||..||.|.......                     |.||.||..||.|.|..|...... .. ...|||.|
deeeeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeekeeeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegee

ALQAIQSMQEDEAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRAL
| .......|.|.||..|||||.|.||.|. .|||||||.|         .||.|.|.|.|.|.||||||| |..|||.|||.||.|||..|||||||||
akeeldgseekeepGedsGttAvvaLlkekklivAnaGDsR.........cvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAl

GDWNYKQNAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGV--VIKAAITELLDACMAPDTeTGDGSGCDNET
||..||.|.||....|.    |||||||.|..|...|||.|||||||||.|.||.|||..|....||   |......||||||.|||| .|||.||||.|
GDhaYkkneeLplkeqm....isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdt.sgDGtGCDnmt

AMVVMLRD
...|.|..
viivllkk

PP2Cc_SM00332 24-484 4e-67 219.5 In-house 13-274 (274) alignment
Range on Protein: 24-484
Range on HMM: 13-274/274.0
KFcvGSMQGWRADQEDAHLAIPDI--DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG----EVTQALQKAFLALDLQIKAEESLAE
..   ||||||  .||||  ..|    | |. .||||||||      .||.|||...| ..|| .  . ..    .|..||.||||..| .| .||.  |
gk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgG......sevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqske

LQQlahagndsddddndseddeedgdniealqadadipidelkrangkradnagetatdgqldqkraklqalltgdlmeddedddeddeddddeddneee
|..                                                                                                 
len.................................................................................................

akdkdskqkqskdgkqstkegddqdqaaddsdedeegveeqafehsesiraqllaalaqhgegsealqaiqsmqedeapgYSSGTTANVMLLNERLAIVA
                                                                                 .||.|| |.||..   .||
................................................................................alsGstavvallkkedlyva

NAGDCRFVLMPPSRlavlcrkgvAMDMSEDHKPEDEPERTRIERAGGTVDSDgRIEGGLNLSRALGDWNYKQNAeldhrdQVRIGSISALPDIQVMELCQ
|.||.| ||.  .          | ..|.||||||| || ||..|||.|  . |. |||..|||.||  .|.|       . .   |.|.||..| .|..
nvGDSravlcrngk.........avqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknk......klkepyitaepdvkvvtlts

DDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvviK----AAITELLDACMAPDtetgdGSGCDNETAMVV
.|||..||.||.|.....|.|||..| . .||   |     .. ||||.. ...     | ..|| |..||
edeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr.....ggseDniTvvvv

0034914 PP2C-like 21-488 4.7e-59 192.6 In-house 19-292 (295) alignment
Range on Protein: 21-488
Range on HMM: 19-292/295.0
FGHKFCVGSMQGWRADQEDAHLAIPDI---DETWACYGVFDGHGGWcyaprpEVSKFVARHLLDCLKAQ-------EGFANGEVTQALQKAFLALDLQIK
. ....| |.||.|  .|||.|.....   .| ....||||||||.      .........|.. |. .         .    . .||.|||||.| .. 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGh......aaaevasellvelllellekllllltlsledieealrkaflaadeell

AEESLAelqqlahagndsddddndseddeedgdniealqadadipidelkrangkradnagetatdgqldqkraklqalltgdlmeddedddeddedddd
..  |                                                                                               
elallr..............................................................................................

eddneeeakdkdskqkqskdgkqstkegddqdqaaddsdedeegveeqafehsesiraqllaalaqhgegsealqaiqsmqedeAPGYSSGTTANVMLLN
                                                                                       . ||||| |.|. 
....................................................................................pelagsGtTavvalir

ERLAIVANAGDCRFVLMppsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSdGRIEGGLNLSRALGDWNYKQNAELDHRDQVrigsISALPDI
.. ..|||.||.|.||.         |.|... ...|||| .| || ||..|||.|   ||. |.|...|||||...|..  | .....    .|| ||.
gnklyvanvGDSravll.........rngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllsllllepl....vsaePdv

QVMELC-QDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMApdtetgdGSGCDNETAMVVMLRD
.|.||  .||.|..||.||.|. ......||..| ...||  ...| .||.|...|       . ..|| |..|| |..
tvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.......rgsrDNiTvvvvrlng

subfamily_PPM1G2_pd Subfamily PPM1G2 291-486 7.5e-50 162.5 In-house 105-286 (287) alignment
Range on Protein: 291-486
Range on HMM: 105-286/287.0
QED-EAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDgRIEGGLNLSRALGDWNYKQ
..| .    |.|.|| |.|..|.  .|||||| |         |||. || .  .| ||||..| |..||. |||.|. . |. | | |||||||...|.
lkdeklkdesaGstavvvlikeeklyvanaGDsr.........avlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkk

NAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTETGdGSGCDNETAMVVML
| ..  ..|.    . |.||. | .| .||||.||||||||. .|...|||..| |...|  ... |.|||| |.|||.... | |||| |...|.|
nvkkkpeeqi....vtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssnt.gvGcDnmtvvivvl

subfamily_PPM1A_pd Subfamily PPM1A 258-486 1.7e-45 148.5 In-house 83-280 (282) alignment
Range on Protein: 258-486
Range on HMM: 83-280/282.0
QAFEHSESIRAQLLAALAQHGEGSEALQ----AiqsmqedeapgyssGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDE
.. |..| .| ..||.  .  | |. |.    .              |.|| ..|..|.  |.||.||.|         |||||.| |. ..|||||...
ekdevkealrqgfLaldeairelstdlktadks..............GsTavtvlvsekhliianlGDsR.........avlcrngkaaflteDHkpsrp

PERTRIERAGGTVDsDGRIEGGLNLSRALGDWNYKQNAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIK
 |..||| |||.|   .|..| | .||||||..||.. |..  .|     .|| |.....|  ..|.|.||||||||  .....||.. | |....  ..
kEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeql....vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadele

AAITELLDACMAPDTEtgdgsgcDNETAMVVML
.  ..|.| ..  ...       || ...||..
evakalvdkalekgsr.......DNlsvlvvlf

PP2C Protein phosphatase 2C 288-469 3.8e-45 147.4 Pfam-A 89-252 (255) alignment
Range on Protein: 288-469
Range on HMM: 89-252/255.0
QSMQEDEaPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRALGDWN
.|... .    .||.|| |.|...   .|||.||.|         ||||||. |   ..|||||.|| || |||.|||.|.  ||. | |..||||||. 
ksskant.epsksGstavvalirgkklyvAnvGDSr.........avLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfe

YKQNAeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTE
.|..             .|| ||... .| ..|||..||.||.|. ...|..||  | . .|.   . |..||.| ..|. .|
lkpke.........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 288-469 3.8e-45 147.4 In-house 89-252 (255) alignment
Range on Protein: 288-469
Range on HMM: 89-252/255.0
QSMQEDEaPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRALGDWN
.|... .    .||.|| |.|...   .|||.||.|         ||||||. |   ..|||||.|| || |||.|||.|.  ||. | |..||||||. 
ksskant.epsksGstavvalirgkklyvAnvGDSr.........avLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfe

YKQNAeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTE
.|..             .|| ||... .| ..|||..||.||.|. ...|..||  | . .|.   . |..||.| ..|. .|
lkpke.........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

PPM_PTC7 297-469 2e-43 141.7 In-house 98-256 (259) alignment
Range on Protein: 297-469
Range on HMM: 98-256/259.0
GYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVD--SDGRIEGGLNLSRALGDWNYKQNAEl
  .||.|| | |...   .|||.||.|         |||||.| |   ..|||||..| || |||.|||.|.  ..||. | |..|||.||. .|..   
pstsGstAvvalitgsklyvAnvGDSr.........avLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket.

dhrdqvRIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvVIKAAITELLDACMAPDTE
      .   .|| |||.. ..  .|||..||.||.|. ...|..||  | .. |.     |...|.| ..|...|
......eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargse

0049733 PP2C-like 285-487 3e-32 104.9 In-house 77-234 (235) alignment
Range on Protein: 285-487
Range on HMM: 77-234/235.0
QAIQSMQEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMppsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVdsdgRIEGGLNLSRALGD
.|. ...... . . .|||| |.|| .. ..|||.||.|..|.         |.| .. ..|||.| .| || ||..||| |    |. |.| |.|||||
eallelalaspelagmgtTavvalldggklyvanvGDsrayll.........rdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGd

WNYKqnaeldhrdqvrigsisalPDIQVMELCQDDeFIVLACDGIWNSMTSQQVVDYLRVrftkgVVIKAAITELLDACMApdtetgdGSGCDNETAMVV
. .|                   ||..|.|| ..| |..||.||.|. ......||.||        ...|  .|.....|       . |.|| |..||
lllk...................pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala.......rggrDNiTvvvv

MLR
.|.
rld

subfamily_ILKAP_pd Subfamily ILKAP 291-443 7.4e-28 90.5 In-house 104-240 (293) alignment
Range on Protein: 291-443
Range on HMM: 104-240/293.0
QEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMppsRLAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVdSDGRIEGGLNLSRALGDWNYKQn
 . . | .  |.|| |.|  . .  ||| || . ||.   |     .| ... .. ||.| .. || ||..|||.|  |||. | |. ||..|| ..|. 
askakPvWkdGstatvvlvldnvlyvanlGdskavlv...rkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdgrvlGvlevsrsiGdgrfkr.

aeldhrdqvrIGsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLR
          .| ... ||.. .|| ..| |.||||||.|.... ..||..  
..........lG.vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfil

subfamily_PPM1E_pd Subfamily PPM1E 294-486 2.5e-26 85.5 In-house 96-262 (265) alignment
Range on Protein: 294-486
Range on HMM: 96-262/265.0
EAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDG--RIEGGLNLSRALGDWNYKQna
|  .. ||.|| |.|....   ||  || .         |.|.||| |. . . ||||.| |. ||| |||.|   |  |. | |..|||.|| ..|.  
ereklksGstavvvliekdqlyvaWlGDsq.........allvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkp..

eldhrdqvrigSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDAcMAPDtetgDGSgCDNETAMVVML
            .|. .|.  .|| ...|...|||||.|. .. ..||. ..  ...|.  .. ...|| . .| .    .||  || |..||.|
...........yvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllve.aake....ags.sDnitvvvvfl

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 283-441 4.6e-25 81.3 In-house 80-219 (255) alignment
Range on Protein: 283-441
Range on HMM: 80-219/255.0
ALQAIQsMQEDEAPgYSSGTTANVMLLNERLAIVANAGDCRFVLMppsrlavlCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSD---GRIEGGLNLS
| ..|. .| .| |    |||| ..|. |   ..|| || | ||          ..|.|  .| |||| .| |. ||...|||| |.    |..| | .|
aykeis.tqiserp.kfiGttaasvliiedkvyianvGdsrvvlc........qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavs

RALGDWNYKQNaeldhrdqvrigsISALPDIQ-VMELCQDDEFIVLACDGIWNSMTSQQVVDY
|||||   .               . . ||..  .|  ..|.|..|||||||. .. .. |. 
ralGdsflePf.............vvpdPdlsqsleiskkdkflilacdGiwdlisdeeavei

subfamily_PPM1G2_pd Subfamily PPM1G2 5-117 5e-22 71.2 In-house 2-112 (287) alignment
Range on Protein: 5-117
Range on HMM: 2-112/287.0
LEKPITDKEFEEGADRFgHKFCVGSMQGWRADQEDAHLAIPDI-----DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVTQALQ
|..|...|| . .|..   |.   .|||.| ..||||.  ...     |.. | ..|||||||       .|.|.....|   ..... |..|...|.|.
lsepvvakesascanal.tkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGG......akvakyagkklikkiakkksfkegaleqilk

KAFLALDLQIKAEESLAE
.|||..| ..  .|.|..
dafletDeellkdeklkd

subfamily_PPM1L_pd Subfamily PPM1L 299-446 5.6e-22 71.3 In-house 105-236 (269) alignment
Range on Protein: 299-446
Range on HMM: 105-236/269.0
SSGTTANVMLLNERLAIVANAGDCRFVLMPpsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDG--RIEGGLNLSRALGDWNYKQNaeldhr
 .|||| . |..|.  |||| || | ||.         ..| |. .| ||||..  || ||..||| .  .|  |..| |  ||||||.  |..      
iaGttalialvqesdlivanvGdsrGvlyd........krGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk......

dQVrigsISALPDIQVMELCQ-DDEFIVLACDGIWNSMTSQQVVDYLRVRF
 ..    . | |||  ..| . . ||..||.||.|.... .. | ... |.
.nl....viadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl

subfamily_PPM1K_pd Subfamily PPM1K 285-445 1.3e-21 69.9 In-house 83-228 (263) alignment
Range on Protein: 285-445
Range on HMM: 83-228/263.0
QAIQSMQEDEAPGYSSGTTANVMLLNERLA-IVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSD----GRIEGGLNLS
.    ..  ||   |||||| | || .    ..|. || |         |.|||.| |. ...||.|| | |. || .|||.|...     ...| | ..
krylefsvaeaellssGttatvsllrdGtelvlaslGdsr.........ailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamt

RALGDWNYKQNaeldhrdqvriGSIsALPDIQVMEL-CQDDEFIVLACDGIWNSMTSQQVVDYLRVR
|.||| . |.            | | | |. . ...  ..| |.||  ||| . ..||.. |..|. 
rslGdldlkry...........Gvi.atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc

subfamily_PDP_pd Subfamily PDP 225-443 1.2e-20 66.9 In-house 75-309 (398) alignment
Range on Protein: 225-443
Range on HMM: 75-309/398.0
QK--QSKDGKQSTKEGDDQDQAADDSDedeEGVEEQAFEHSESIRAQLLAALAQHGEG--SEALQAIQSMQEDE-APGYSSGTTANVMLLNERLAIVANA
.|  .... |....  . ... ...     . ..|..  . |... .|  |  .  .   .|||.. .. . .| .    ||..| . |....   |||.
lkllkkskhkldvvsdeakklslsels...kylqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAnt

GDCRFVLmppsrlAVLCRKG--VAMDMSEDHKPEDEPERTRIERAGGTVD-----SDGRIEGGLNLSRALGDWNYKQNAELDHRDQVR-----IG-----
|||| ||      .|   .|   |. .|.|.  . | | .||...    .      .||. | |  .|| || .|| ..||...   .     .      
GDcravl......gvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyk

---SISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLR
    ..| |...  .| ..| |.||| ||.|.......||..  
tPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVg

PPM_PTC7_SpoIIE 283-458 1.8e-17 56.9 In-house 72-216 (230) alignment
Range on Protein: 283-458
Range on HMM: 72-216/230.0
ALQAIQSMQEDEAPG--YSSGTTANVMLLNERL--AIVANAGDCRFVLMPPSRLavlcrkgvamdmsedhkpedepERTRIeRAGGTVD---SDGRIEGG
.|...    ... .    |||.|| | |..       ||||||....|. ...                       ||.||  ||| ..    .||. | 
ilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg......................ereri.vagglpslGilpgrvfgv

LNLSRALGDWNYKQnaeldhrdqvRIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvvikaAITE
|..|.| ||  ..             | ..| || .  || ..|||..||.||.|. ...|..|| .| .. |      |  .
lavslapGdlllly..........tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeg

subfamily_PP2D1_pd Subfamily PP2D1 304-446 2.5e-16 52.5 In-house 180-306 (492) alignment
Range on Protein: 304-446
Range on HMM: 180-306/492.0
ANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDS---DGRIEGGLNLSRALGdwNYkQNAELDHrdqvr
 .| | .  .  .||||. .         |||||.|.|. .  .| |... ||||.|.||..| .    |...| |.  | ||  ||  . .| .     
sevhleelgvlyianaGnvq.........AvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLG..ny.GdpkLkk.....

igSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRF
  |.   | .. ..| . . |.|||  |.|. .. ..|.  ..  .
..svipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl

subfamily_PPM1A_pd Subfamily PPM1A 18-115 2.4e-15 49.6 In-house 7-108 (282) alignment
Range on Protein: 18-115
Range on HMM: 7-108/282.0
ADRFGHKFCVGSMQGWRADQEDAHLAIPDIDET--WACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGF--------ANGEVTQALQKAFLALDL
|.  | ...| ||||||.. |||| .. .. ..  |. . |||||.|       ||.|.|..|||. .  .| .         . || .||...||||| 
aegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaG......sevakyvkkhllenileeeelkeaaleasekdevkealrqgfLalde

QIKAEESL
.|..... 
airelstd

subfamily_KAPP-like_pd Subfamily KAPP-like 313-462 8e-13 41.0 In-house 106-248 (266) alignment
Range on Protein: 313-462
Range on HMM: 106-248/266.0
LAIVANAGDCRFVLM--PPSRLAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTV-DSDGRIEgGLNLSRALGDWNYKQNAeldhrdqvrIGSISAlPD
||.| ..|. |..         | |.|   .. .| ||| .|. |. ||   | |. |.. ||. || .||||||   |.           || ||  | 
lalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikeln.........iGlise.py

I-QVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDA
. . . |   |.|...| ||.|. .. .. .. ... . ..   .   . ||..
vsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassllet

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 332-462 9.7e-12 37.3 In-house 137-258 (276) alignment
Range on Protein: 332-462
Range on HMM: 137-258/276.0
LAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTV-DSDGRIEgGLNLSRALGDWNYKQNAeldhrdqvrIGSISAlPDI-QVMELCQDDEFIVLACDGI
 | |.|   .. .| ||| .|  |. ||   | |. |.. ||. || .||||||   |.           || ||  | . . . |   |.|...| ||.
saflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikeln.........iGlise.pyvsnrilltpfdkflivasdGl

WNSMTSQQVVDYLRVRFTKGVVIKAAITELLDA
|. .. .. .. ... . ..   .   . ||..
wdvisGkdaiekvkslydqqatedkmassllet

PPM_PTC7 27-113 4.4e-11 35.7 In-house 5-91 (259) alignment
Range on Protein: 27-113
Range on HMM: 5-91/259.0
VGSMQGWRADQEDAHLAIP-----DIDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLALDLQIKAEE
. ..||.|   ||||.| .     . .. .| ..|||||||       |..|... || ..|| .. | .. .. .|| |.|||||. .. . 
asafqgfrksmedahialanlesssgkdsvaffavfdghgg......reaakyarehleeilkerksfeeleklekalrksflaldtdeelks

PP2C Protein phosphatase 2C 27-111 1.7e-10 33.9 Pfam-A 5-90 (255) alignment
Range on Protein: 27-111
Range on HMM: 5-90/255.0
VGSMQGWRADQEDAHLAIPD-----IDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLA-LDLQIKA
. ..||.|   ||||.|...      ....| ..|||||||       |..|. . || ..|| |. |  . .| .||.|.||| .| ..| 
aselqgarksmedahialknlekssgkssvaffavfdghgg......reaakyarehleeilkeqksflelekvekalrksfladtdeelks

PP2C Protein phosphatase 2C 27-111 1.7e-10 33.9 In-house 5-90 (255) alignment
Range on Protein: 27-111
Range on HMM: 5-90/255.0
VGSMQGWRADQEDAHLAIPD-----IDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLA-LDLQIKA
. ..||.|   ||||.|...      ....| ..|||||||       |..|. . || ..|| |. |  . .| .||.|.||| .| ..| 
aselqgarksmedahialknlekssgkssvaffavfdghgg......reaakyarehleeilkeqksflelekvekalrksfladtdeelks

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 297-387 1.9e-10 33.8 In-house 82-185 (292) alignment
Range on Protein: 297-387
Range on HMM: 82-185/292.0
GYSSGTTANVM-LLNERLAIVANAGDCRFVLMppsRLAVlCRKGVAMDMSEDHKPEDEPERTRIERAGGTVD----------SDGRI------EGGLNLS
. |..|..      ..|  |.|| || | .|    |      .   . .| ||||||  || || |||| |.             |.      ||.| ||
resattavvcarvrddralilanvGdsrallg...rclg.gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlals

RALGDWNY
|||||   
ralGdfhl

0049733 PP2C-like 24-112 2e-10 33.7 In-house 4-82 (235) alignment
Range on Protein: 24-112
Range on HMM: 4-82/235.0
KFCVGSMQGW-RADQEDAHLAipdideTWACYGVFDGHGGWCyaprpeVSKFVARHLLDCLKAQ-EGFANGEVTQALQKAFLALDLQIKAE
.... |..|. |  .|||.|.       .....|.|||||.       ........|...|... ...   ....||.|||||.. .. ..
svgaasdigrvrkvneDavlv......glllfavaDGhggha......agevasellvetllelllelllldleealrkaflaaneallel

subfamily_TAB1_pd Subfamily TAB1 262-434 4.1e-10 32.0 In-house 92-261 (333) alignment
Range on Protein: 262-434
Range on HMM: 92-261/333.0
HSESIRAQLLAALAQHGEGSE---ALQAIQSMQEDeapgYSSGTTANVMLLNERLAIVANAGDCRFVLMPPSRlavlcrKGVAMDMSEDHKPEDEPERTR
  .... ||   ....   ..    ....|...|.     | |||| | |.      |||.|| | .|.   .      .     .| ||. . | | .|
ekddlqsqlPegvssyeleeqypekierlqeleee....isgGttAvvalifnnkLyVaNvGdsrAllvkrke......sekvkqLsvdHttdNedEllR

IERAG---GTVDSDGRIeGGLNLSRALGDWNYKQN-AELDHRDQVRIGSISALPDIQVM-ELCQDDEFIVLACDGIWNSMT
... |    .. . .|. |. .  |..||.. |.   . |   . .   . | ||||   .. .   |.||  ||. ... 
lkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLe

subfamily_PPM1D_pd Subfamily PPM1D 48-112 5.6e-10 31.8 In-house 32-93 (309) alignment
Range on Protein: 48-112
Range on HMM: 32-93/309.0
DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG---EVTQALQKAFLALDLQIKAE
.  .|. .|||||||       | .||. .||.  .| |..| .    .|..|...||||.  ..| .
elevafvavfDGHGG......keAakfarehlwsvikkqkkflssepedvleAireaflatheamkkk

subfamily_PPM1D_pd Subfamily PPM1D 299-368 6.3e-10 31.6 In-house 107-173 (309) alignment
Range on Protein: 299-368
Range on HMM: 107-173/309.0
SSGTTANVMLLNERLAIVANAGDCRFVLMPPSRlavLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDS
 .|||| |... ..   ||. || . ||          .| .|  . .|||||.  |..|||..|| |  
taGttasvviirreklyvahvGDsaivlgvkep...kekklrakeltkdHkPespeekerieelGGevaa

subfamily_PHLPP_pd Subfamily PHLPP 333-444 4e-09 28.7 In-house 117-214 (246) alignment
Range on Protein: 333-444
Range on HMM: 117-214/246.0
AVLCRKGVAMDMSEDHKPEDEpERTRIERAGGTVDSDGRIEGGLNLSRALGDWNYkqnaeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNS
|||.|.|  . .|. .. |.. |  ||  | . .. |..|.| .. .| ||                   ..   | .. . | ..||....  . .|..
avliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytfl.............fPvvlPkphvrevlLteqdellivGnkalWev

MTSQQVVDYLRV
.  ...|. .| 
lsideaveavrk

subfamily_PPM1D_pd Subfamily PPM1D 376-486 5.6e-09 28.5 In-house 201-307 (309) alignment
Range on Protein: 376-486
Range on HMM: 201-307/309.0
LNLSRALGD-WNYKQNAEldhrDQVrigsISALPDIQVMELCQDDE-FIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAA----ITELLDACMapDTE
|...|.||| | |... .      |    .|  ||..|..| ...| ||.|| ||.|| .|....|. ..   .|... .       . |..  .  .. 
LavaRslGDlWsynaksg....efv....vsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkeal..qrw

TGDGSGCDNETAMVVML
      .|| ...||.|
rskklraDnvsvivvil

PPM_PTC7_motif 423-469 1.4e-08 28.1 In-house 1-48 (51) alignment
Range on Protein: 423-469
Range on HMM: 1-48/51.0
VLACDGIWNSMTSQQVVDYLRVRFTK-GVVIKAAITELLDACMAPDTE
.||.||.|. ...|..|| .| . .| |     |...| | ..|. .|
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargse

PPM_PTC7_SpoIIE 27-111 1.5e-08 27.7 In-house 5-86 (230) alignment
Range on Protein: 27-111
Range on HMM: 5-86/230.0
VGSMQGWRADQEDAHLAIP-----DIDETWACYGVFDGHGGWCyaprpevsKFVARHLLDCLKAQEgFANGE-VTQALQKAFLALDLQIKA
. ..||.|   |||| . .     . . ... .|..|||||          ......| ..|...  ||..| . ..|....|||. ... 
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra........alamgllrtalrela.faglekpeeilrrlnlalaadled

subfamily_PPM1E_pd Subfamily PPM1E 26-110 5.1e-08 25.4 In-house 7-92 (265) alignment
Range on Protein: 26-110
Range on HMM: 7-92/265.0
CVGSMQGWRADQEDAHLAIPDIDE--------TWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVtQALQKAFLALDLQIK
 . .... |  .|| |.|..|..|        . | ..|||||||       | .|. |.||   |  || . .  . .||..|| ..| .. 
siaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgG......veaakyaaahlhellvrqeklkedpa.ealkeafkltDerfl

subfamily_PPM1H_pd Subfamily PPM1H 244-357 3.1e-07 22.5 In-house 109-210 (404) alignment
Range on Protein: 244-357
Range on HMM: 109-210/404.0
AADDSDEDEEGVEEQAFeHSESIRAQLLAALAQhgegSEALQAIQSM--QEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMPPSRLavlcrkgva
 ...|....    .. . . ..|... |   |      .| . . ..  .| ||   . | || | |. .    ||||||.| .|.  ...         
nteesskespssvseiy.eekeiskeeLviGal....esaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdei.........

MDMSEDHKPEDEPERT
...|.|. || | .| 
iplsadftPeteRqRl