Gene LMWPTP in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP086_AA protein Get Run
NvecP086_AA_2-153 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 6-153 1.8e-69 222.3 In-house 2-151 (152) alignment 
Range on Protein: 6-153
Range on HMM: 2-151/152.0
RSVLFVCLGNICRSPTSEAILRHLLAQKGLDKQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRP-
..|||||||||||||..||.||.|...|||...||.|||||  .||||.||.|.|.|.|..|. ..|||||...|||.|| .|||.|..|...|..|.. 
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

-KDGTAKVELFGKYDPDGVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMKK
 |. .|||.|.|.|| .| .||||||||||.|||..||....||..|.||
kkeskakvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk
0046251 Phosphotyrosine protein phosphatases I 4-152 1.5e-47 151.8 In-house 4-156 (159) alignment 
Range on Protein: 4-152
Range on HMM: 4-156/159.0
ECRSVLFVCLGNICRSPTSEAILRHLLAQKGLDKQ-WKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQL
.  .|||||.|||||||. ||.|||||...||... .  |||.....|||..||.| .|. |. |.. .|||||. ||||.|| |||| ||.|..|| .|
mkkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrl

RPKDGTAKVELFGKYDPDG---VTIIEDPYYGDEDDFEVMYKHCYRCCQEFMK
 |.| ..|| |.......    .. ..|||||. ..|| ..............
apgdargkvllllefagllellhwdvpDPyyggleaFeevldlieeavealle
0053360 Phosphotyrosine protein phosphatases I 3-152 3.4e-47 150.5 In-house 3-154 (157) alignment 
Range on Protein: 3-152
Range on HMM: 3-154/157.0
DECRSVLFVCLGNICRSPTSEAILRHLLAQKGLDKQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQL
..  .|||||.|||||||..||.|||||...||....  ||| ....|||...|.| ... .. |.. .|||||. |||..|| |||. ||.|...| .|
skmkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellpl

RPK--DGTAKVELFGKYDPDGVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMK
 |.  . ..|| |......  .  ..|||||....|| ..............
fpglleakgkvllllefagllhwdvpDPyyggleafelvldlieeavealle
0048765 Phosphotyrosine protein phosphatases I 6-152 7.8e-47 149.3 In-house 3-151 (154) alignment 
Range on Protein: 6-152
Range on HMM: 3-151/154.0
RSVLFVCLGNICRSPTSEAILRHLLAQKGLDKQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRPK
 .|||||.|||||||..||.|||||...||....  ||| ....|||...|.| ... .. |.. .|||||. |||..|| |||. ||.|...| .| |.
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfpg

--DGTAKVELFGKYDPDGVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMK
  . ..|| |......  .  ..|||||....|| ..............
lleakgkvllllefagllhwdvpDPyyggleafeevldlieeavealle
LMWPc Low molecular weight phosphotyrosine protein phosphatase 8-151 2.7e-40 128.5 Pfam-A 1-138 (138) alignment 
Range on Protein: 8-151
Range on HMM: 1-138/138.0
VLFVCLGNICRSPTSEAILRHLLAQKgLDKQWKLDSAAIGPWhVGKRPDRRGLAIQKREGVPNT-HRARQVCEEDFREFGLILAFDDENVQDLEQLRPKD
|||||.|||||||..||.||.|| .. | .... |||... . ||...|.| ... |..|.. . |||||. ||...|| |||..|.|....|... |. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

GTAKVELFGKydpdgVTIIEDPYYGDEDDFEVMYKHCYRCCQEFM
 .||| |.|.      . |.|||...|..|| ... . .......
keakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 8-151 2.7e-40 128.5 In-house 1-138 (138) alignment 
Range on Protein: 8-151
Range on HMM: 1-138/138.0
VLFVCLGNICRSPTSEAILRHLLAQKgLDKQWKLDSAAIGPWhVGKRPDRRGLAIQKREGVPNT-HRARQVCEEDFREFGLILAFDDENVQDLEQLRPKD
|||||.|||||||..||.||.|| .. | .... |||... . ||...|.| ... |..|.. . |||||. ||...|| |||..|.|....|... |. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

GTAKVELFGKydpdgVTIIEDPYYGDEDDFEVMYKHCYRCCQEFM
 .||| |.|.      . |.|||...|..|| ... . .......
keakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
0042188 Phosphotyrosine protein phosphatases I 5-153 1.4e-39 125.7 In-house 4-142 (146) alignment 
Range on Protein: 5-153
Range on HMM: 4-142/146.0
CRSVLFVCLGNICRSPTSEAILRHLLaqkglDKQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNT-HRARQVCEEDFREFGLILAFDDENVQDLEQLR
  .|||||.|||||||. ||.|||||     ....  ||| ....|||...|.| ... .. |.. . |||||. |||..|| |.|. ||.|..|| .| 
kkkvlfvCtgNicRSpmAeallrhll.....gdrvevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplf

PKDGTAKVELFGKYDpdgvtIIEDPYYGDeDDFEVMYKHCYRCCQEFMKK
|.  ..|| |....       ..|||||. ..|| ...............
pgaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkallel
LMWPc_SSU72_ArsC 7-143 3.3e-38 121.4 In-house 2-126 (126) alignment 
Range on Protein: 7-143
Range on HMM: 2-126/126.0
SVLFVCLGNICRSPTSEAILRHLLAQkgldkQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRPKD
.|||||||||||||..||.|......     ... .||..|....||..|.|  .. |..|.. .|..||. |||..|| |||..|..|.... .| |..
kvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellper

GTAKVELFgkydpdgVTIIEDPYYGDEDDFEVMYKHC
 |.||.|.        . ..|||.|.|..|| .....
atkkvhll.......nldvkDpyegaesgfeevldli
0051181 Phosphotyrosine protein phosphatases I 7-152 6.6e-32 100.4 In-house 1-123 (124) alignment 
Range on Protein: 7-152
Range on HMM: 1-123/124.0
SVLFVCLGNICRSPTSEAILRHLLAQkgldkqWKLDSAAIgpwHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRPkd
.|||||.|||||||..||.|||||..      .. ||| .   |.|...|.| ... .. |.. ..|..|. |.|..|| |.|..||.|...| .|.|  
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap..

gtakvelfgkydPDGVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMK
                  ..|||||....|| ..............
............lllhwdvpDPyyggleefeevldlieervealle
0047618 Phosphotyrosine protein phosphatases I 7-152 1.1e-31 99.9 In-house 3-134 (137) alignment 
Range on Protein: 7-152
Range on HMM: 3-134/137.0
SVLFVCLGNICRSPTSEAILRHLLAQKgldkqWKLDSAAIGPWHvgkrPDRRGLAIQKREGVPNT-HRARQVCEEDFREFGLILAFDDENVQDLEQLRPK
.|||||.|||||||..||.|||||...     .. ||| ..|..    .|.| ... .. |.. . ||..|. |.|..|| |.|. ||.....| .| |.
kvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllapa

DGTAKVelfgkydpdgvtIIEDPYYGD------EDDFEVMYKHCYRCCQEFMK
  ....             ..|||||.      ...|| .......... ...
alrlhw............dvpDPyygggteeekleafervldlieervealle
0047572 Phosphotyrosine protein phosphatases I 6-152 1.5e-27 86.4 In-house 3-129 (130) alignment 
Range on Protein: 6-152
Range on HMM: 3-129/130.0
RSVLFVCLGNICRSPTSEAILRHLLaqkglDKQWKLDSAAIGPWHvgkrPDRRGLAIQKREGVPN-THRARQVCEEDFREFGLILAFDDENVQDLEQLRP
 .|||||.||.|||| .||.|||||      .... .|| .....    .| | ... .. |..  .||..|. |....|| |... ||.....| .| |
kkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGtegsg....vdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap

KDGTAKVelfgkydpdgvtIIEDPYYGDEDDFEVMYKHCYRCCQEFMK
.  .. .             |.|||.|. ..|. ... ..|.......
aalrlhw............dipDPygggleafrevrdlierrvlalle
LMWPc_SSU72 7-153 2.5e-27 86.4 In-house 2-137 (137) alignment 
Range on Protein: 7-153
Range on HMM: 2-137/137.0
SVLFVCLGNICRSPTSEAILRHLLAqkgldkQWKLDSAAIGPWHVGKRPDRRGLAIQKREGVPNTHRARQVCEEDFREFGLILAFDDENVQDLEQLRPKD
.|||||..||.||. .||.|.. |.      ... .|| .|....|...|..  .. |..|.  ....... ||....| |............ .  |. 
kvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlper

--GTAKVELFgkydpdgVTIIEDPYYGDEDDFEVMYKHCYRCCQEFMKK
   ..|| ..          |.||.... ..|. ... . ....|....
selkrkvhvi.......nvdikDpheeaiegfkaildlieervkellae