Gene PPP1C-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP113_AA protein Get Run
NvecP113_AA_5-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 22-301 4.9e-165 540.6 In-house 2-281 (282) alignment 
Range on Protein: 22-301
Range on HMM: 2-281/282.0
SRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
|..||.|.|.||||. |. |.|||.||||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDR
|||||.|||||||||||||||||.|||||||||.|||||.||..||||.|.||||||.|.|.||||.|.||..||..|||||||||||||.|.||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK
|||||||.|.|.|||.|.|||||.||||||||||||||||||||.|||||||||||||||..||||.|..||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 8-301 2.9e-140 459.9 In-house 2-296 (300) alignment 
Range on Protein: 8-301
Range on HMM: 2-296/300.0
NVDSIISRLLEVR-GSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
..| || .||.    ..  ||| | ..||  .| |.||.||.|| ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||.|||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK
|||    . | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| ||.||| | |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-302 3.7e-138 452.6 In-house 2-297 (298) alignment 
Range on Protein: 8-302
Range on HMM: 2-297/298.0
NVDSIISRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||......|.|  |      ...|...  |. ....|| .|. |.|..||.|.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||| ...|...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKK
.||.. |.|| || ||||..|| | |...|.| |.||..|||||| |||||||...|||.||||.|||.|||. |.|.||| |..||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 8-302 4.4e-130 426.3 In-house 2-297 (299) alignment 
Range on Protein: 8-302
Range on HMM: 2-297/299.0
NVDSIISRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.|| ..|.||.|  |       . | |.. ||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. ..  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKK
.|||. |..|  | ||||. ||.|.||. ... |.||..||||||.|||||||...|||.|||| |||.|||. |.| ||| |.|.|..|||..|.
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 31-299 2.2e-121 397.3 In-house 7-275 (280) alignment 
Range on Protein: 31-299
Range on HMM: 7-275/280.0
TEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
 ||.| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPD
|| |||.||.||||. .|.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  ||||.||...| ||.|| ||||  || .
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

IVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.| .. .| |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||| |. ||..||||
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0045823 Metallo-dependent phosphatases 18-302 1.9e-120 395.6 In-house 31-327 (473) alignment 
Range on Protein: 18-302
Range on HMM: 31-327/473.0
EVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
..  ..  |. .|.| ... |. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||.|
dlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgn

FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVQG--
.||||||||.. .| .|||.||. ..|...|.. | .....||.||....||...||||||||....|||.| || ..|| |||.|||||||  .. |  
vfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdg

------WGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDETLmCSFQILKPADKK
      .| . ||....||||.| .||.|..||||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .||.| .||....|.. .
llrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp
0049330 Metallo-dependent phosphatases 6-302 1.9e-118 387.9 In-house 6-302 (309) alignment 
Range on Protein: 6-302
Range on HMM: 6-302/309.0
KLNVDSIISRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
.| ....| .||..  ... | ..|.| |.. |.|| .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||....||.|.||||||||....|||...||...|. |||||||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdll

WSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKK
||||. .. |...|.||....||...| .||.|..||||.|.|..|..||..|....|.|.||||||||...|.||.. .||.|..||....|.. .
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PP2Ac_SM00156 31-299 5.3e-117 382.7 In-house 2-270 (271) alignment 
Range on Protein: 31-299
Range on HMM: 2-270/271.0
TEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. |.. |. ...||. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPD
|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|.|...||.. |. . |..|||.|||||||.....|.  . ||.|..||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.| .||.|..|.||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 31-285 8.5e-116 378.8 In-house 2-264 (264) alignment 
Range on Protein: 31-285
Range on HMM: 2-264/264.0
TEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ....|||.......|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDVQGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
....||.|...|||.|..|.||.|||.|.|.||||..||..||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 30-297 4.9e-115 376.2 In-house 2-270 (271) alignment 
Range on Protein: 30-297
Range on HMM: 2-270/271.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.| |.. |. | .||. ....|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
||....||.|..|.||.|||...|.|||.......||.|||||||....||||.....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 30-298 1.4e-112 368.8 In-house 8-282 (284) alignment 
Range on Protein: 30-298
Range on HMM: 8-282/284.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| |.  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| |.||...|.|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
  .||.. | .||.|..|||. |||||| ||||||| |.|||.|||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-301 1.7e-108 355.4 In-house 7-276 (284) alignment 
Range on Protein: 34-301
Range on HMM: 7-276/284.0
EIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
..  | ... .||  ||.|.| ..|..||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYNI-KLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDVQGWGENDRGVSFTFGPDI
||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| | || | |.   |  |.||||| .  .||  | ||||. || | 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK
. |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.. |.||| .|.|  |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
0053225 Metallo-dependent phosphatases 11-298 4.9e-108 353.8 In-house 3-290 (293) alignment 
Range on Protein: 11-298
Range on HMM: 3-290/293.0
SIISRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
|.| .||..  ..  ....|.| |.. |.|. .||....|.||||.... ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||....||...|||||||| ...|||.|.||...|. |||.|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
| .. ||. . ||....||...| .||.|..||||.|.|||| |||... ...|||.||||||.|...|.||.. .|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-299 1.7e-107 352.1 In-house 2-295 (297) alignment 
Range on Protein: 9-299
Range on HMM: 2-295/297.0
VDSIISRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
|||||  .|            .||  .  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.   ..|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
||.||   . |. ||.||    || | | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|| | |||.||.|.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPP4C_pd Subfamily PPP4C 30-299 1.4e-104 342.4 In-house 16-285 (288) alignment 
Range on Protein: 30-299
Range on HMM: 16-285/288.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| |.. || |.|||.. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVQGWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||.|.|||| ||||||.......|| | | ..||..| |||||||||. |..||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

PDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 |.|..| .. |..|||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP2C_pd Subfamily PPP2C 28-302 5.8e-104 340.3 In-house 15-289 (290) alignment 
Range on Protein: 28-302
Range on HMM: 15-289/290.0
VQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 ||.|.|.. || | .||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVQGWGENDRGVSFT
  | ..||||||| |.| | ..|| ||| |..||..|..||.||| |||||| ......|| . |  .||..| |||||||||| | .|||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKK
|| ||  || .. .| || ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .|| ..
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-301 3.8e-100 327.7 In-house 5-279 (281) alignment 
Range on Protein: 27-301
Range on HMM: 5-279/281.0
NVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. ||  .  . . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..|  .... | ||||||.| .....| . .| . .|.||. ||||.|||..|..| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK
|| ..| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. |||||  |.. | || .
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 85-299 5.6e-98 321.0 In-house 101-315 (317) alignment 
Range on Protein: 85-299
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |.|||..|.|. |  || .. ||.. | .||.|.||||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 30-301 1.1e-95 312.8 In-house 10-284 (287) alignment 
Range on Protein: 30-301
Range on HMM: 10-284/287.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... .|  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDVQGWGEND-RGVSFT
||..|||..| ||... .|.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  ||||.||.|| ..   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK
||   | ..|.| |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| | 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP6C_pd Subfamily PPP6C 29-297 4.2e-95 311.2 In-house 14-282 (290) alignment 
Range on Protein: 29-297
Range on HMM: 14-282/290.0
QLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|.... || .  ...| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVQGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |..|||.||...| |||||||.. ..||| | | ...| .| .|||.|||| .||. |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
|  .. .|.|  .|.|||||||.||.|.... . .|||..||||||    |  ........   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPP3C_pd Subfamily PPP3C 28-290 8.7e-90 294.6 In-house 39-314 (452) alignment 
Range on Protein: 28-290
Range on HMM: 39-314/452.0
VQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 .|.|...  .  .. ... ... |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...|||||||||
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

ASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWG-------END
  .   . | .||| .|. .........|..||.||.|... .|.||||||...|...|... |  ..| .|.||||||||| .| .          .. 
rhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDETLM
|| |. ..   |..||.| ||  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  |
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 31-299 3.8e-88 288.6 In-house 7-275 (280) alignment 
Range on Protein: 31-299
Range on HMM: 7-275/280.0
TEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
|  ||  .      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPD
|.||||| ||. .| . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  |.||| ||||||| .  .||  . ||.|. ||  
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkg

IVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.| .  .  ..||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
vveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPG1_pd Subfamily PPG1 29-300 4.6e-87 285.1 In-house 13-297 (300) alignment 
Range on Protein: 29-300
Range on HMM: 13-297/300.0
QLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .. |. | .|.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDVQG--
 | ..|||| || |.|  | ..|| .|. |. | .|||.||.|.| ||||||. .|..||. . |  .||..| |.|||||||.          | .|  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
. . .||  ...| |.| |||.. |.. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_PPP5C_pd Subfamily PPP5C 40-288 5.7e-86 281.4 In-house 44-298 (322) alignment 
Range on Protein: 40-288
Range on HMM: 44-298/322.0
LKSREIFLSQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIY
|...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdVQGWGENDRGVSFTFGPDIVA
|| .|.| .|. |. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |..|||..||||||..  .| ..  |||...||||.  
GfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtk

KFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DET
|||.. .|.|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... .. 
kflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
PPP_2 60-250 9e-84 273.1 In-house 2-197 (198) alignment 
Range on Protein: 60-250
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    .|||... ... .. ||....||||.....|.|..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 30-299 2.2e-83 272.6 In-house 16-289 (290) alignment 
Range on Protein: 30-299
Range on HMM: 16-289/290.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... .|  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDKDV-QGWG-ENDRGVSF
.||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  ||||.||..|  .    .  |..| 
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

TFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 || . . ..|.|  |.|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |.|  |. .||| 
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
PPP_4 60-250 9.7e-81 263.5 In-house 2-196 (197) alignment 
Range on Protein: 60-250
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFN
 ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| ......|| ||||| .. .|. .. ||....||||.. |||.|..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 60-251 5.3e-77 251.3 In-house 2-199 (199) alignment 
Range on Protein: 60-251
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVQG-WGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVV
..||.||..|||....||||||...|.|....| |....| ..|  .|| ||||| ....| . .. ||....||||.. |||.|..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 26-295 8.2e-77 251.4 In-house 16-288 (307) alignment 
Range on Protein: 26-295
Range on HMM: 16-288/307.0
KNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
...| |  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ECASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRG
| | .|. ||||.||     .   ..|  |  ||| ||..|..  ||.| |||||| |  ....|   .|   | .|.. |.||.|||  |  |    ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQI
  |||| ...    ..  ..|| ||||.. |||  .. |.|.|.|||| ||  . |||... |||||      
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlva
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 86-303 2e-76 250.3 In-house 121-338 (339) alignment 
Range on Protein: 86-303
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.... |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |.|||   .|.    || || |||  .  ||.| ||... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPADKKK
|. |  | ....|  . |
dkklkisinvfrpesrdk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 52-300 5e-74 242.3 In-house 2-257 (263) alignment 
Range on Protein: 52-300
Range on HMM: 2-257/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDVQGWGEND-RGVSFTFGPDIVAKFLHKHDLDLI
 ... | . |. .|..||. ..|.| |||.|| |.|...|| |  | .    . | |||||.||.|| .|.  |  | .|  ||   |  . .. |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 29-298 1e-68 224.7 In-house 5-299 (302) alignment 
Range on Protein: 29-298
Range on HMM: 5-299/302.0
QLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPdK
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp.l

DVQG---------WG-ENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
|||.         .  .. ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|..
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 29-297 2.1e-68 223.7 In-house 6-299 (302) alignment 
Range on Protein: 29-297
Range on HMM: 6-299/302.0
QLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPdK
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp.l

DVQG---------WG-ENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
|||.         .  .. ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 37-290 1.2e-57 188.5 In-house 4-280 (290) alignment 
Range on Protein: 37-290
Range on HMM: 4-280/290.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIKL---WKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWSDPDKD-----------V
 . .. |.. ..  .|   |..|...|. ||.||..|.|.||.|.|.    ..  .|   . |.   . |.    |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

QGWGEND-RGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAgAMMSVDETLM
.|. .|| || .  |. | . .||.. .|. . |||.| | |...  | .|.|.||. .|||  ..| |.. ||.  .
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkkl
Metallophos Calcineurin-like phosphoesterase 59-250 5e-45 147.2 Pfam-A 3-198 (200) alignment 
Range on Protein: 59-250
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwsdpdkdvqgwge
                        ... . .  . ..|..|| .|. | ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGPDIVAKFLHKHDLDLICRAHQV
     |. |||| . |.| |...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 59-191 3.4e-38 124.3 In-house 66-201 (383) alignment 
Range on Protein: 59-191
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAILDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|...||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 201-293 1.3e-21 69.8 In-house 237-329 (383) alignment 
Range on Protein: 201-293
Range on HMM: 237-329/383.0
LCDLLWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSF
. |.||||| ..   . .  ||    ||||. .|.|.|..|.|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 30-83 2e-17 56.4 In-house 9-62 (317) alignment 
Range on Protein: 30-83
Range on HMM: 9-62/317.0
LTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPP
..|.|.  ||...||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-84 7.1e-13 41.3 In-house 12-65 (339) alignment 
Range on Protein: 31-84
Range on HMM: 12-65/339.0
TEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPE
  ||.  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 60-178 6.1e-08 25.4 In-house 13-138 (235) alignment 
Range on Protein: 60-178
Range on HMM: 13-138/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRYNI-----------
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .            
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

----KLWKTFTDCFNCLPVA-AILDEKIFCCHGGLSP
    || |  ..    |. .  |  ....  |.||.|
flesklskadmeyarelgfsldipsdellvvhaGlvp