Gene PPP1C-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP114_AA protein Get Run
NvecP114_AA_21-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 25-300 4.7e-149 488.2 In-house 3-278 (282) alignment 
Range on Protein: 25-300
Range on HMM: 3-278/282.0
NPGKQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLR
..||.|.| ||.|..... .|||.|.||.|||. ||..|.|||||||.|||| |.. |.||...|.||||||||||.|||||.|||||||||....||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRG
||||.|||||.|||||||||||.|||||.|||.|||||.||.|.. |.|.||||||.|. |..||...||..||.|||.|||||||||....||..||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILKV
||.||| |||...|.|. ..|.|||||||||||.||.||.|||.||||||||||||||.|.|| |.|..||.||| 
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 11-299 7.1e-129 422.1 In-house 2-292 (298) alignment 
Range on Protein: 11-299
Range on HMM: 2-292/298.0
DVDNVIEQLLSYKKNPGKQV-QLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLL
.||... ..||  ..  | . .. |... ........|| .|..|.|. |||.. ||||||| |||| ||| |.||.. |.|||||||||...||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRY-NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLW
||||.|| ...|||||||||..||||||||.|||||| ...|.. | | || ||..|.. . |.|||||||. |. ||..|.|.||.| ... |. ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
.||.. ..|| .| |||| .|| |||.. |||    ||||||||| ||| || ..||||.||||.|||.|||. .||.| |.|..|| .||
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_PPZ_pd Subfamily PPZ 10-298 1.4e-128 421.6 In-house 1-291 (300) alignment 
Range on Protein: 10-298
Range on HMM: 1-291/300.0
LDVDNVIEQLL--SYKKNPGKQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETIC
.|.|..|..||   |  .  |.| | ...| |||. .||.|| || |||.  ...| ||.|||| |||| | | |.||   |.||||||||||.||||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLL
|||.||||| ...|||||||||| . |||||||||||| |||.|| | | || ||.||||   |||.|||||| |. .|||| . || |||| ||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSIL
|||| .    | ||.||||. .    . ..|.|.|| ||.||| |||||| ||. | |||.|||||||||||| | |||| | |.||| .|
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 10-300 1.6e-122 401.4 In-house 1-293 (299) alignment 
Range on Protein: 10-300
Range on HMM: 1-293/299.0
LDVDNVIEQLLSYKKNPGKQV-QLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICL
||||... .||.  .. ..    . | .....|.|....|..|. |||. ||| . ||||||| |||| ||| |.||.  ..|||||||||.. ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYN-IKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLL
||..|||| .. |.||||||| .||||||||.||..||.  .|| || |.|. .|.. ..   |.|||||||| || || .|.| ||.| |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILKV
|.|||. . .|  | ||||. || |||.. ... .  || ||||||.||| || ..||||.|||| |||.|||.  .| | |||.|.| .|| 
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkp
0045823 Metallo-dependent phosphatases 22-300 5e-114 374.5 In-house 33-323 (473) alignment 
Range on Protein: 22-300
Range on HMM: 33-323/473.0
YKKNPGKQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVF
...   |. .||| .......  .||. ..|.|||. ..| ..||||||..|||| ..|.|.||.. ..||||.||||  |||...||||.|||| ..||
liehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvf

LLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPdEDITG----
|||||||.. .| .|||.||. ..|...|.. | .....||.||.....|...||||||||. ||.||..||| ..|| ||..||||||| ... |    
llrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgll

----WGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRK------LVTLFSAPNYCGEFDNAGGVMSVGENLmCSFSILKV
    .| . ||....|| |.|.| |.|.|. |.||.|..|..||... ..|      ..|.||||||||...| ..|. ..|.| .|| ... 
rlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp
PP2Ac_SM00156 34-299 2e-113 370.9 In-house 3-268 (271) alignment 
Range on Protein: 34-299
Range on HMM: 3-268/271.0
EAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASIN
. ....... ..||. |...|.|. ||. ..||||||..|||| ... |.||.| |.|||||||||..|.|.|.||.|.||.|...|.|||||||. |.|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGDV
..|||..|.||.|. .....|...|..||.||.|...|.||||||||.|. ||.||.|.|. . |..||..|||||||...  |.  . ||.| .|| |.
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
|.|.|.|. ..|..|||.||..||.|| ..||||.|||||||.||.|.. |..| .||..|.  ||
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 34-300 1.4e-112 368.4 In-house 8-274 (280) alignment 
Range on Protein: 34-300
Range on HMM: 8-274/280.0
EAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASIN
||.| .. .  ..|.. |  ..|. ||... ||.|||| |||| |.. ..||.. |.|||||||||.. || |.||||||..| .. ..||||||..|||
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

RVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGDV
| |||.||.||||. .|.. | . .. ||..|.|   |.|||||||..|. ||....| ||.| .|. |  ||||.||....|||..| ||||  || .|
rkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganv

VREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILKV
|... ||    |..| ||||.||| || ..||||.||||.|.|||||. .|. | |.|. || .|| 
vkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
0049330 Metallo-dependent phosphatases 22-299 1.2e-109 359.1 In-house 20-297 (309) alignment 
Range on Protein: 22-299
Range on HMM: 20-297/309.0
YKKNPGKQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVF
... . |...|.| .......  .||....|.|||....| ..||||||..|||| ..|.|.||.  ..||||.||||  |||...||||.|..| |.||
lielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvf

LLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDN
|||||||.. .|..|||.||..|.|...||. |.|....||.||.....|.|.||||||||. ||.||.||||...|. ||.||||||||.... |...|
llrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapn

DRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
.||....|| ..|...|.|.|..|..|.|..|..||..| ..||.|.||||||||...|.|.|. ..|.|..|| ...
prglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfe
PPP_3 32-298 2.8e-108 354.0 In-house 2-269 (271) alignment 
Range on Protein: 32-298
Range on HMM: 2-269/271.0
LPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECAS
|.| .......  .||. ....|.|| ||....||||||..|||. |.. | .|...|.||||||||||||||...||||.||||...|.|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRVYGFYDECK-RRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFG
||.||||..|.. .... |..| ....|..||.||.........||||||... ||.|..|||...||..|...|||.|...|. .|.. ..||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

GDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSIL
 ||..| |||. ..|..|||...|.||......|.||.|||||||....||| .....|.|...| .|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 31-300 1.4e-105 345.9 In-house 7-282 (284) alignment 
Range on Protein: 31-300
Range on HMM: 7-282/284.0
QLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYP------PNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLR
 | | .. ..|  .||.| .... ||| ||..| ||||||.||||  .|  |.|       .. |.|||||||||  |.| | ||.|||... |.|||||
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllr

GNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRG
||||   .|. |||| |||.||  .|...|  .||..|..|.|.. |.|||||.| ||  |... .||||.|.|| |...|| |.||.....|. . .||
gnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

VSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILKV
   .|| . |.|.|.|. . ||||||||| ||| ||  |||||.|||| |||..||.. |..| |.|..||..|| 
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 35-299 2e-104 342.0 In-house 6-272 (284) alignment 
Range on Protein: 35-299
Range on HMM: 6-272/284.0
AQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINR
 ..  .   . .|| .||||.|. .|||| ||||||. |||| ||| |.|    |.||||||||||. |||| ||.|||. . ...|.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYDECKRRYNI-KLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDK-GLVCDLLWSDPDEDITGWGDNDRGVSWTFGGD
.||||.||.||||   ... |   |  .|..|.| | |.|||||.|  || . ..| ..||.| |.   |  |.||||| .   ||  | ||||. || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
 .|. |..    |||||||||.||| || .|.|||.|||| |||.||||  || | .||.||| .|.
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlr
PPP_1 34-286 5.8e-104 340.0 In-house 3-263 (264) alignment 
Range on Protein: 34-286
Range on HMM: 3-263/264.0
EAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASIN
|........ ..|.. ....|||. ..| . ||||||..|||. | . | .|...|.||||||||||.|.|...||||.|.|| ...||||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RVYGFYDECK-RRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLL-------WSDPDEDITGWGDNDRGV
.||||..|.. ..|. ...|..||.|..||.||.... |...||||||.|. ||.||...| ..||..| .||||       .||..|. ... ...||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMS
...|| ||....|.|....|..|||.|.|.||.|..|||.||.|||.||. |..|.| ...
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0053225 Metallo-dependent phosphatases 24-299 6e-102 333.9 In-house 14-289 (293) alignment 
Range on Protein: 24-299
Range on HMM: 14-289/293.0
KNPGKQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLL
.   ....|.| .......  .||....|.|||....| ..|||||...|||. ..|.|.||.. ..||||.||||  |||...||||.|..| |.|.||
elllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvll

RGNHECASINRVYGFYDECKRRY-NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDeDITGWGDND
|||||.. .| .|||.||..|.| . .||. ..|....||.||.....|...||||||||  ||.||...||...|. ||..|||||||| ...||. . 
rGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsy

RGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
||....|| ..|...|.|.|. |..|.|||| |||... ..||||.||||||.|...|.|.|. ..|.|...| ...
rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 29-296 6.6e-99 323.7 In-house 5-272 (281) alignment 
Range on Protein: 29-296
Range on HMM: 5-272/281.0
QVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHE
.||. . .| .. .  . || ..  | || .|| . ||.|.|..|| | |. || .|.| ..|||||||||..|||.. ||...||.| |...|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWT
 ||.|..|||| ||. .| ..||  |  ||| |||.| ... . ||||||||.|  |||.||  .|.. .|.||| ||||.|||..  .|    ||.|.|
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFS
|| .|| .   . .  |..|||||| |||. .. |||.|.||.||||  . ||. |. | |.|  |. 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislv
subfamily_PPP4C_pd Subfamily PPP4C 11-299 1.9e-97 318.9 In-house 2-283 (288) alignment 
Range on Protein: 11-299
Range on HMM: 2-283/288.0
DVDNVIEQLLSykknpgkQVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLL
|.|. ||.| .          . | .....|. .|||....  . .. .|. . ||||||..|||. |.  |  |...|.||||.||||. |.||. |||
dldrqieklrr.......celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllll

AYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRY-NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWS
|.|..| |.. |.|||||. .| .|||||||| |.| ....|.  |. |. |..|||... |||.||||||... ||||| ..|  .||..| .||||||
alkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllws

DPdEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
|| ||..||.   ||  . || ||| .. |. ...|..||||.| .||..  ..|..|..||||||    |   .. . |.|   |.|..
dp.edaegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_PPP2C_pd Subfamily PPP2C 12-296 6.6e-97 317.2 In-house 4-281 (290) alignment 
Range on Protein: 12-296
Range on HMM: 4-281/290.0
VDNVIEQLLSYKknpgkqvQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLA
.|..||.| . |       || |......|.  .||. ..  . |. .|. . ||.|||. |||  |   |  |.  |.|||||||||  |.||..|| |
ldklieklkeck.......qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllva

YKIKYSDQVFLLRGNHECASINRVYGFYDECKRRY-NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSD
 |..| ... .||||||   | .|||||||| |.| | ..||.||| |..||..|.|.. |||.|||||| .. ||.||.|.|  .||..| .|||||||
lkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsd

PDeDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFS
|| | .|||  .||  .||| |. ... .. |..|..||||.| .||..  .|..||.|||||||    | .... . ..|  || 
pd.drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysfl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 12-299 6.6e-96 314.1 In-house 2-293 (297) alignment 
Range on Protein: 12-299
Range on HMM: 2-293/297.0
VDNVIEQLLSYKKNPGKQV-QLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLL
||..| ..||           . | .. .. ... ..| .|  ..|. |||.. ||||||. |||| | . |.||   |.|||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYN-IKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSP---DLQGLDEIRNLERPMDVpDKGLVCDL
|||.|.  ..|||||||||  .|.|||||.||..||. ....  | | || ||.. .. . |.||||||||   .   || .|..||. .   ..||.||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
||.||   ..|. .|.||    || | | .   .. . ||.||||||.||| ||  |||||.|||| |||.|||.  .||. |.| ||| ||.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 33-299 1e-95 312.9 In-house 11-280 (287) alignment 
Range on Protein: 33-299
Range on HMM: 11-280/287.0
PEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASI
 . .| .. .  .||.   | |||. |||.|.||||||..|||| |.. |..|.  |.||||||||| |||| . ||...||.|. .| |||||||.  |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDV--PDKGLVCDLLWSDPDEDITGWGDN-DRGVSWTF
|..|||..| ||... .|.| | | |. ||. |.|.. |.|||||.||.|. ||... |..|      |.||. ||||.||..|  .   |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

GGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
|  .| ..|.| . .|.||||.|.|.|| |. ...|||.|||| |.||  | | |. | . |  ||  ||
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 87-299 1.5e-92 303.2 In-house 101-313 (317) alignment 
Range on Protein: 87-299
Range on HMM: 101-313/317.0
ESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLD
. |.|||||||||  |.| . ||.|.|..| |.|||||||||  ..|. |||| |.|.||. .|...|   ||.||..|.|...|.|||||.| .|  |.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

EIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMS
.. .|.||.|.|| |...|| |.|||....|. .  || .  || . |.|.|.|. . ||||||||||||| ||. |||||.||||.|||..||.. |.|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VGENLMCSFSILK
| ..|..|...|.
vdkklkisinvlr
subfamily_PPP6C_pd Subfamily PPP6C 31-292 2e-89 292.5 In-house 14-275 (290) alignment 
Range on Protein: 31-292
Range on HMM: 14-275/290.0
QLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECA
 |||......|..  ...|..  .  . .|. . ||||||. ||.  | . |  |..||.||||.||||  ||||. .||. |.|| |.. |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRVYGFYDECKRRY-NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPdEDITGWGDNDRGVSWTF
 | .||||||||...| | . || .|. |. |.||||... ..|.|||||||.. ||.|| .|| ...| || .|||.|||| ||.  |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLM
|  |..|...   ..|..||||.||.|.... . ||||..||||||    |   .... ..  
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 30-299 1.6e-88 289.5 In-house 14-287 (290) alignment 
Range on Protein: 30-299
Range on HMM: 14-287/290.0
VQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHEC
  . . .| .| .  .||.   | |||. ||| |.|||||| ..|||.||..||||.  ..||||||||| ||||   ||. |||.|| .| |||||||.
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

ASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMD--VPDKGLVCDLLWSDPDE--DITGWGDNDRGV
  .||.|||..|  |. . .||| . | |. |.. | |.. |.|||||.|....  . .. |..|      |.||. ||||.||..  | |   .  |..
rkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrai

SWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
|  || ... ..|.| ..||.||||.| |.|. |  ..||||.|||| |.|.  | | .. | | |  |. .||
svvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 37-297 3.2e-87 285.6 In-house 11-271 (280) alignment 
Range on Protein: 37-297
Range on HMM: 11-271/280.0
IRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVY
|  | ..   ||...  | |  |||.. |||| ||.|. | || .|  |.|  .||||||||| . .| . ||.. ||.| |...|||||||  |.|..|
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiy

GFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGDVVRE
||| ||. .| . ||  |  ||| .|..... . ..||||||||.|  || |||. || .  |.||. ||||||| .   ||  . ||.|. ||  || .
gfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveq

YLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSI
  .     |..||||||.||| ..  |.|.|.|| |||| .| ||  |. .  ||  ||  
acksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_PPP3C_pd Subfamily PPP3C 29-292 1.8e-83 273.8 In-house 38-314 (452) alignment 
Range on Protein: 29-292
Range on HMM: 38-314/452.0
QVQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHE
. .| |... .| . . ... ... |||. ||| . ||||||. |||. |.  | | . .|.|||||||||  |.|..  |.| ||.|....||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWG-------DN
|  .   . | .||| .|. .... ....|..||.||...|  .|.||||||... ||.|..|.|  ..| .|..|||||||| ||            ..
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEK------RKLVTLFSAPNYCGEFDNAGGVMSVGENLM
 || |. ..   | |.|.|  .  ..|||.. ..||| ..|        |.||||||||.. ..| . |. . .| |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPP5C_pd Subfamily PPP5C 28-295 3.5e-79 259.1 In-house 30-303 (322) alignment 
Range on Protein: 28-295
Range on HMM: 30-303/322.0
KQVQLPEAQIRQICQVSREIFLQQPMLLEIGAP----INIFGDIHGQYEDLLRHFDKLGYPPN-ESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFL
|| .|..  . .| . ..|.. ..| |.||  .    . . ||||||. |||  |.. |.| . ..|.| ||.||||  |.|.| .||..|. | ...||
kqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhffl

LRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGL-SPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEdITGWGDN
 |||||  ..|..||| .|.| .|. |. ..||. || ||.| .... .. .|||| | |   ||..|...| .. |..||...||||||.|  .| .  
srGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrsps

DRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSV-GENLMCSF
 |||. .|| || ...|.. ...|..|.|.| |.||.. .. ||.|.||||||| . .| |..... |..|   |
krGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
subfamily_PPG1_pd Subfamily PPG1 30-297 5.5e-79 258.5 In-house 12-292 (300) alignment 
Range on Protein: 30-297
Range on HMM: 12-292/300.0
VQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHEC
  |||. ......  .|.....  . || .|. . ||.|||. |.|  |.  |  |.  |.|||||||||  |.||| ||.. |..|  .. ||||||| 
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhes

ASINRVYGFYDECKRRY--NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPD---------EDITG-
  | .||||| || |.|  | ..|| .|. |. | .|||... |.|.||||||. . .|.|. |.|  .||..| ..|||||||.          |  | 
rqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregq

-WGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSI
 .   .||  ...| ||| ..|..  .  ..||||.. .||. .   || |..||||||    |   .. . |..   | .
hfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 36-291 1.9e-78 256.8 In-house 24-282 (307) alignment 
Range on Protein: 36-291
Range on HMM: 24-282/307.0
QIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRV
.. ..   .. ||  .  |..|  |  . ||.|||..||.  |  || ||.  |.| |||||||  |||.| ||..||| |.... ||||||| | .|. 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECKR---RYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGD
||||.||     .   ..| .|  ||| |||.|..   |.|||||||| |  |||.||  .|.  | .|.| |.||.|||  .  |    ||  .||| .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

VVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENL
|. .   . |  |..||||.. |||  .  |||.|.|||| ||  . ||| |. | | |
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl
PPP_2 61-252 7.7e-77 250.5 In-house 1-197 (198) alignment 
Range on Protein: 61-252
Range on HMM: 1-197/198.0
INIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECK-RRYNIKLWKIFTDCFN
....||.|||..|||. |.. . .|...|.||||||||||||||...||||.|..| ..|.|||||||....|.||||..|.. .... |..| ....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPDKGLVCDLL----WSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQV
.||.||.........|||||.... ||.|.. ||....|..|...|||    .|||.|. ...  . ||....|| ||..| |||. ..|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 61-252 1.3e-74 243.5 In-house 1-196 (197) alignment 
Range on Protein: 61-252
Range on HMM: 1-196/197.0
INIFGDIHGQYEDLLRHFDKLG-YPP-NESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCF
. ..||||||..|||  . |.|  |. ..||.||||||||||.|||...||||.|..| ..|.|||||||..|.|..|||..|...... ...|...|.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVP-DKGLVCDL-LWSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQV
..||.||.........|||||..|. ||.|...||....| .... .|| ||||| |. .|. .. ||....|| ||... |||....|..|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 88-298 2.6e-72 236.8 In-house 121-331 (339) alignment 
Range on Protein: 88-298
Range on HMM: 121-331/339.0
SYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDE
 |.|||||||||  |.| . || | |. | |...|||||||  |.|  |||| | . ||. .|.. | . || .|..|....||.|||||.|  |  ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRNLERPMDVPDKGLVCDLLWSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSV
.  ..||...|| |.. || |.|||    |.    || |. ||   .| .|.|  . .|.| |||||||| ||. |.|||.||||||||. ||.  |.|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

GENLMCSFSIL
 ..|  |  ..
dkklkisinvf
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 30-299 5.3e-71 232.3 In-house 4-298 (302) alignment 
Range on Protein: 30-299
Range on HMM: 4-298/302.0
VQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFD----------KLGYP-PNESYIFLGDYVDRGKKSLETICLLLAYKIKYSD
 .. . .. ....   | . ..  | || .|. | ||||||.|||.| .           |  |   .. ..|||||||||.||.| |||..|.|. |  
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

QVFLLRGNHECASINRVYGFYDECKRRY----NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPM-DVPDKGLVCDLLWSDPDE
.  |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.| . |.|.|||.|| |. |..|....||. .| .  |  |||..|| .
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

D--------ITGWG-DNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
            .  .. ||.| .|    ||.  ......|.|||||..  |..|| ..||.|.||||.|  | || | |. |  |   | |.|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
PPP_5_Dcr2 61-253 8.8e-71 231.0 In-house 1-199 (199) alignment 
Range on Protein: 61-253
Range on HMM: 1-199/199.0
INIFGDIHGQYEDL-LRHFDKLGYPP-NESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRR-YNIKLWKIFTDC
. ..||.|||..|| |. |.. | |. ...|.||||||||||.|||...||||.|..| ..|.|||||||. ..|..|||..|.... .. |..||..|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVP-DKGLVCDL-LWSDPDEDITG-WGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVV
|..||.||.........||||||... .......||....| .||  .|| ||||| .. .| .  . ||....|| ||... |||....|..|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 30-299 9.4e-71 231.4 In-house 5-299 (302) alignment 
Range on Protein: 30-299
Range on HMM: 5-299/302.0
VQLPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFD----------KLGYP-PNESYIFLGDYVDRGKKSLETICLLLAYKIKYSD
 .. . .. ....   | . ..  | || .|. | ||||||.|||.| .           |  |   .. ..|||||||||.||.| |||..|.|. |  
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

QVFLLRGNHECASINRVYGFYDECKRRY----NIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPM-DVPDKGLVCDLLWSDPDE
.  |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.| . |.|.|||.|| |. |..|....||. .| .  |  |||..|| .
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

D--------ITGWG-DNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
            .  .. ||.| .|    ||.  ......|.|||||..  |..|| ..||.|.||||.|  | || | |. |  |   | |.|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 54-299 1e-68 224.8 In-house 2-254 (263) alignment 
Range on Protein: 54-299
Range on HMM: 2-254/263.0
LLEIGAPINIFGDIHGQYEDLLRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRYNI-----
|||. ||||| || ||||.|||| |.  |   .  |.||||||||| .||| | ||.. |.    ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIRNLERPMDVPD-KGLVCDLLWSDPDEDITGWGDND-RGVSWTFGGDVVREYLEKYGFSLV
 ... | . |. .|..||| . |.|||||.|| |. ||.|| .  |..    . | |||||.||..|  |.  |  | .|  ||   | .  ..    |.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSFSILK
|||||||| || ||  |.|.|.|||  |  |. |   |. | . |  ||  ||
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlk
subfamily_PPPLV_pd Subfamily PPPLV 38-284 2.2e-55 181.0 In-house 3-273 (290) alignment 
Range on Protein: 38-284
Range on HMM: 3-273/290.0
RQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRH---FDKLGYP-PNESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASIN
  .|.|. .|....  |||. .|. ..||.||.|.||      . ..|      |..|||||||||. |.| |. ||| |. |  .|.|||||||  |. 
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

RVYGFYDECKRRYNIKL---WKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEI---RNLER--PMDVPDKGLVCDLLWSDPDEDI----------
  . .. |.. ..  .|   |. |...|. ||.||......||.|.|.    ..   |   ...    . |.    |  |.|||||.||           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-TGWGDNDR-GVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGV
  |. |||| | .  |. | .  .|.. . | |.|||.| | |.|. .| .|.|.||. .|||  ..|  .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaali
Metallophos Calcineurin-like phosphoesterase 60-252 2.2e-44 145.1 Pfam-A 2-198 (200) alignment 
Range on Protein: 60-252
Range on HMM: 2-198/200.0
PINIFGDIHGQYEDL----LRHFDKLGYPPNESYIFLGDYVDRGKKSLETICLL--LAYKIKYSDQVFLLRGNHECASINRVYGFYDECK----------
.| ..||.||...||    |. ... .....  ..||||.||||. |.||..||  |..|......|||||||||. ..| .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYNIKLWKIFTDCFNCLPIAAIVEQTIFCMHGGLSPDLQGLDEIrnlerpmdvpdkglvcdllwsdpdeditgwg
                         ... . .  . ..|..||..|.|...|...||.||....  | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dndrgVSWTFGGDVVREYLEKYGFSLVVRAHQV
      |. || |.... |||||  ||.|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-193 6.2e-37 120.2 In-house 62-201 (383) alignment 
Range on Protein: 57-193
Range on HMM: 62-201/383.0
IGAPINIFGDIHGQYEDLLRHFDKLGYPP-NESYIFLGDYVDRGKKSLETICLLLAYKIKYSDQVFLLRGNHECASINRVYGFYDECKRRY---NIKLWK
|   . . ||.||. .|||  . | |.|  ...|.| ||.|||||.|.| ...|||. . |  .|.| |||||   .|  |||  | . .|   . |. .
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

IFTDCFNCLPIAAIVEQTIFCMHGGLSpDLQGLDEIRNLER
.. | |  ||.|..... |. .|||.| |   |. . ..||
lledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 203-295 3.1e-20 65.2 In-house 237-329 (383) alignment 
Range on Protein: 203-295
Range on HMM: 237-329/383.0
VCDLLWSDPDEDITGWGDNDRGVSWTFGGDVVREYLEKYGFSLVVRAHQVVEDGYRFFEKRKLVTLFSAPNYCGEFDNAGGVMSVGENLMCSF
| |.||||| ..   . .  ||    || || .. |.||...|..|.|.   .|| |  ..|..|.||| ||  |  | |  . .|..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 32-85 4.4e-15 48.6 In-house 9-62 (317) alignment 
Range on Protein: 32-85
Range on HMM: 9-62/317.0
LPEAQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYPP
. |... ..|  .||.| ..|. ||. ||. | ||||||.||||  .|  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 35-84 1.5e-10 33.7 In-house 14-63 (339) alignment 
Range on Protein: 35-84
Range on HMM: 14-63/339.0
AQIRQICQVSREIFLQQPMLLEIGAPINIFGDIHGQYEDLLRHFDKLGYP
|.. ..|. .||.   .|..|.. ||| ..||||||..|||  .|  |.|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 61-180 3.1e-10 33.0 In-house 12-138 (235) alignment 
Range on Protein: 61-180
Range on HMM: 12-138/235.0
INIFGDIHGQYEDLLRHFD--KLGYPPNESYIFLGDYVDRGKKSLETICLLlaykikYSDQVFLLRGNHECASIN------RVYGFYDE--CKRRYNI--
. . ||.|| |..|.. .|  . |  .|   ...|| ...| ||.|.. ..       .|||  ..|||| . .       .  |. .    ..   .  
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

KLWKIFTDCFNCLPIA-AIVEQTIFCMHGGLSP
|| |  ..    |. .  |  . .. .|.||.|
klskadmeyarelgfsldipsdellvvhaGlvp