Gene PFKFB-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP126_AA protein Get Run
NvecP126_AA_220-442 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 222-418 1e-97 317.3 In-house 1-197 (198) alignment 
Range on Protein: 222-418
Range on HMM: 1-197/198.0
NIHITPKAIYLTRHGESEYNLKGRIGGDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIkGVSTEKWAALNEIDAGVCEGMTYEEIQE
|||..|. |||.||||||.| ||||||||.|..||. | .|||.|..|..|...||||||.||||||.|.. |...|.| ||.|.|||.|.|.|||||.|
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.glpkeqwkaLdeldaGkcdgltyeeike

NFPEDFAKRDEDKFHYRYRRGESYEDLVARLEPVIMELER-QHNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLTTEAYGCKIEQFDLHI
.|||.|..|..||..|||.|||||||||.||||||.|||| |.|||...|||| |.||||.|||..|||||.|||||.|.|||..|||||.|...|..
kfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
6PF2K 6-phosphofructo-2-kinase 10-227 2.7e-89 288.4 Pfam-A 6-223 (223) alignment 
Range on Protein: 10-227
Range on HMM: 6-223/223.0
APKIVNVPVVIVMVGLPARGKSFISRKLARYLNWIGVSTKVFSLGDYRRRMLEGsQFDHSFFDPNNPNGMNIREECAKLVLADIVEWLK-DKGKVAIFDA
...  | ..|||.||||||||..||.|| |||.|.||.|||| .|.|||.. .  . | .||.|.|......||..|. .| |....|. ..|.||||||
vknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavka.lsdaeffrpdneealklreklalaalkdllkylneeegqvaifDA

TNSTRKRRETIIEKCQSYECRVMFLESVVDDPVIVKSNVMAVKISSPDYKGVQPEQACEDFLARIEHYEQAYEPLCMAKDRHVSYLKIINGGKQFVANKI
||.||.||..|.| ... ...|.|||||..|. |.|.|.. ||.||||||. ..|.| .||| |.|.||..||||   .|...||.|.|. ||..|.|..
tNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnv

EGYLESRIVYYMMNIHITP
.|||.||||||..||| .|
qgylqsrivyyllNihlkp
0039931 Phosphoglycerate mutase-like 230-436 1.9e-61 199.4 In-house 2-207 (219) alignment 
Range on Protein: 230-436
Range on HMM: 2-207/219.0
IYLTRHGESEYNLKGRIGGDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIkGVSTEKWAALNEIDAGVCEGMTYEEIQENFPEDFAK
.||.||||.|.|..||. |||.|. ||| . ..|.|......|. ..|..| ..|.||| |.| |.. | . .|.|||.|..||.|.|||.|..||..|.
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.glpveidprLrEidfgdlegltleeiaekypeelaa

RDEDKFHYRYRRGESYEDLVARLEPVIMELERQHNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLTTEAYGCKIEQFDLHIPAVNTHRQKPE
. .|...||. .|||..|.|||..|...||....|||||.|..| |.||||.|. ..||......| .||..|. ...|.... ..|. .  ...|... 
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllll

DVSVSRD
.... . 
tlellll
0035570 Phosphoglycerate mutase-like 230-442 2.8e-60 195.7 In-house 2-213 (219) alignment 
Range on Protein: 230-442
Range on HMM: 2-213/219.0
IYLTRHGESEYNLKGRIGGDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIkGVSTEKWAALNEIDAGVCEGMTYEEIQENFPEDFAK
.||.||||.|.||.||. ||..|. ||| . ..|.|..|..... ..|..| ..|.||| |.| |.. | . .|.|||.|..||.|..||.| .||..|.
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.glpveidprLrEidfgdlegltldeiaekypeelaa

RDEDKFHYRYRRGESYEDLVARLEPVIMELERQHNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLTTEAYGCKIEQFDLHIPAVNTHRQKPE
. .|...||. .|||..|.|||..|...|||...|||||.|..| |.||||.|. ..||......| .||..|. ...|.|..   | . .. ... ...
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllell

DVSVSRDSAHALQ
 .|. . .|. |.
llslllveallll
0053607 Phosphoglycerate mutase-like 227-414 1.6e-54 176.5 In-house 1-187 (191) alignment 
Range on Protein: 227-414
Range on HMM: 1-187/191.0
PKAIYLTRHGESEYNLKGRIGGDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIkGVSTEKWAALNEIDAGVCEGMTYEEIQENFPED
.. .|| ||||.|.|..||. ||..|. .|| . ..|||..||. |.  .|..| ..|..|| |.| |.. | . .|.|||.|..||.|.||..|..||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.glpvevdprlrEidfgdwegltleelaekypee

FAKRDEDKFHYRYRRGESYEDLVARLEPVIMELERQHNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLTTEAYGCKIEQF
.|.. .|...||. .|||..|..||..|...|| ...|||||.|..| |.||||.|. ..|||.....| .||..|. . .|.... .
laawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvll
0037864 Phosphoglycerate mutase-like 221-414 4e-52 168.9 In-house 1-207 (211) alignment 
Range on Protein: 221-414
Range on HMM: 1-207/211.0
MNIHITPKAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIK---G---VSTEKWAALNEIDAGVCE
|....... .||.||||.|.|..||. |  |..|. .|| . ..|.|..|...|.  .|..| ..|.||| |.|    |   .. | . .|.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

GMTYEEIQENFPEDFAKRDEDKFHYRYRRGESYEDLVARLEPVIMELERQ-----HNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLTTEAY
|.|.|||.| .||.....  |....|.  |||..|.|||..|...|| ..     .|||||.|..| |.||||.|. ..|||.....| .||..|. . .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKIEQF
|.... .
gwvlvsl
0036777 Phosphoglycerate mutase-like 228-411 1e-51 168.2 In-house 3-226 (247) alignment 
Range on Protein: 228-411
Range on HMM: 3-226/247.0
KAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG------VSTEKWAALNEIDAGVCEGMTYEEI
| .||.||||.|.|. ||. |  |..|. .|| . ..|.|...|..|.  .|..| ..|.||| |.| .      .  ... .|.|.| |..||.|..||
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

QENFPEDFAKRDEDKFHYRY-------------------------RRGESYEDLVARLEPVIMELERQ-----HNVLVVCHQAVGRCLLAYFLDKNYEEL
.| .||.....  |...||.                           |||..|.|||..|...|| ..     .|||||.|..| |.||||.|. ..|..
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

PYIKVPLHSVLKLTTEAYG--CKI
.....| .|...|. ...|   ..
lrlnlpngsitvleldddgklwvl
0049178 Phosphoglycerate mutase-like 227-415 3.4e-51 166.5 In-house 3-227 (243) alignment 
Range on Protein: 227-415
Range on HMM: 3-227/243.0
PKAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIK---G---VSTEKWAALNEIDAGVCEGMTYEE
.. .|| ||||.|.|..||. |  ||.|. .||   ..|.|..||..|.  .|..|  ||.||| |.|    |   .  ... .|.|.| |..||.|..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQENFPEDFAKRDEDKFHYRY-----------------------RRGESYEDLVARLEPVIMELERQ-----HNVLVVCHQAVGRCLLAYFLDKNYEELP
|....||..... .|....|.                         |||..|..||..|...|| ..     ..||||.|..| |.|||..|. ..|||.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YIKVPLHSVLKLTTEAYGCKIEQFD
....| .||..|. . .|.... ..
rlnlpngsvtvlelddggwvlvsln
0043909 Phosphoglycerate mutase-like 228-411 3.8e-51 166.2 In-house 3-228 (249) alignment 
Range on Protein: 228-411
Range on HMM: 3-228/249.0
KAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG------VSTEKWAALNEIDAGVCEGMTYEEI
| .|| ||||.|.|..||. |  ||.|. .||   ..|.|...|....  .|..| .||.||| |.| .      .  |.. .|.|.| |..||.|..||
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

QENFPEDFAKRDE-----------------------------DKFHYRYRRGESYEDLVARLEPVIMELERQ-----HNVLVVCHQAVGRCLLAYFLDKN
 | .||.....                               |....|. .|||..|.|||..|...|| ..     .|||.|.|..| |.||||.|. .
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

YEELPYIKVPLHSVLKLTTEAYGCKI
.|.......| .|...|. ...|...
ledilrlnlpngsitvlelddggkpv
0051064 Phosphoglycerate mutase-like 226-410 1.1e-50 165.1 In-house 2-224 (241) alignment 
Range on Protein: 226-410
Range on HMM: 2-224/241.0
TPKAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG------VSTEKWAALNEIDAGVCEGMTYE
..| .|| ||||||.|. ||. |  |..|. .|| . ..|.|..|.. ..  .|..| ..|.||| |.| .      .  . . .|.||| |..||.|.|
mmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltle

EIQENFPEDFAKRDEDKFHYRY-------------------------RRGESYEDLVARLEPVIMELERQ-----HNVLVVCHQAVGRCLLAYFLDKNYE
||.| |||.......|....|.                          .|||..|..||..|.. || ..     .|||||.|..| |.||||.|. ..|
eiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglple

ELPYIKVPLHSVLKLTTEAYGCK
||.....| .||..|. ...|..
ellrlnlpngsvtvleldddgkr
0048955 Phosphoglycerate mutase-like 229-407 1.1e-49 161.7 In-house 2-218 (240) alignment 
Range on Protein: 229-407
Range on HMM: 2-218/240.0
AIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG------VSTEKWAALNEIDAGVCEGMTYEEIQ
 .|| ||||||.|..||. |  |..|. .|| . ..|.|..|.. ..  .|..| ..|.||| |.| .      .  . . .|.|.| |..||.|..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

ENFPEDFAKRDEDKFHYRY-------------------------RRGESYEDLVARLEPVIMELE-----RQHNVLVVCHQAVGRCLLAYFLDKNYEELP
|.|||..... .|....|.                          .|||..|..||..... ||      ...|||||.|..| |.||||.|. ..||..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YIKVPLHSVLKLTTEAY
....| .||..|. . .
rlnipngsvtvlelddg
0036887 Phosphoglycerate mutase-like 228-413 1.2e-49 160.8 In-house 2-194 (202) alignment 
Range on Protein: 228-413
Range on HMM: 2-194/202.0
KAIYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAeqKLQDFRVWTSEFKRTIQTTEHIK---GVSTEKWAALNEIDAGVCEGMTYEEIQEN
. .||.||||.|.|..||. |  |..|. .|| . ..|.|..|  .|. ..|..| ..|.||| |.|    |.. . . .|.||| |..||.|.|||.| 
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

FPEDFAKRDEDKFHYRYRRGESYEDLVARLEPVIMELERQ---HNVLVVCHQAVGRCLLAYFLDKNYEELPYIK-VPLHSVLKLTTEAYGCKIEQ
.||..|..  |....|. .|||..|.|||......|| ..   .|||||.|..| |.||||.|. ..|.|.... .| .||..|. ...|.... 
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
0050036 Phosphoglycerate mutase-like 230-403 1.8e-42 136.8 In-house 3-166 (171) alignment 
Range on Protein: 230-403
Range on HMM: 3-166/171.0
IYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMaeqklQDFRVWTSEFKRTIQTTEHIKgVSTEKWAALNEIDAGVCEGMTYEEIQENFPEdf
.|| ||||.|.||.||. |  |..|. .|| . ..|.|..     .  .|..|  .|..|| |.|  .. ... .|.|.| |..||.|..||.. .||  
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.lpvivdprLrErdfGawegltldeiaakype..

akRDEDKFHYRYRRGESYEDLVARLEPVIMELErqHNVLVVCHQAVGRCLLAYFLDKNYEELPYIKVPLHSVLKLT
  .. |......  |||..|..||. |.. ||   .|||||.|..| |.|||..|. ..||......| .||| |.
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvle
His_Phos_1 Histidine phosphatase superfamily (branch 1) 230-377 8.2e-38 122.8 Pfam-A 2-158 (158) alignment 
Range on Protein: 230-377
Range on HMM: 2-158/158.0
IYLTRHGESEYNLKGRIGGDSD--LSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG---VSTEKWAALNEIDAGVCEGMTYEEIQENFP
.||.||||||.| .||. |.||  |. .||   ..|.. .....|.  .|.||..||.|||.| .     . ..|  .|.|.|.|..||...||..|.||
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

EDFAKRDEDKFHYRYRRGESYEDLVARLEPVIMELE----RQHNVLVVCHQAVGRCL
|...|...||...|. .|||..|...|..|...||     .. |||.|.|..| |.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 230-377 8.2e-38 122.8 In-house 2-158 (158) alignment 
Range on Protein: 230-377
Range on HMM: 2-158/158.0
IYLTRHGESEYNLKGRIGGDSD--LSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG---VSTEKWAALNEIDAGVCEGMTYEEIQENFP
.||.||||||.| .||. |.||  |. .||   ..|.. .....|.  .|.||..||.|||.| .     . ..|  .|.|.|.|..||...||..|.||
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

EDFAKRDEDKFHYRYRRGESYEDLVARLEPVIMELE----RQHNVLVVCHQAVGRCL
|...|...||...|. .|||..|...|..|...||     .. |||.|.|..| |.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_TIGAR_pd Subfamily TIGAR 230-382 1.1e-13 43.4 In-house 3-174 (222) alignment 
Range on Protein: 230-382
Range on HMM: 3-174/222.0
IYLTRHGESEYNLKGRIGGDS--DLSHRGRLYGEKLAEFMAEQKLQdfRVWTSEFKRTIQTTEHIKGVSTEKWAA-------LNEIDAGVCEGMTYEEIQ
... ||||.|.| .. . | .   || .|.   ...|......|..  .. .|. .|. ||.| |. .. ||  .       | | . || ||....|..
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

E------NFPEDFAKRDEDKFHYRYRRGESYEDLVARLEPVI------MELERQHNVLVVCHQAVGRCLLAYFL
|      |.|..  .  |     . |  .. |.|.|..  .        .  .  .||||.|... | ||....
ellkaagnvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlh
AAA_33 AAA domain 19-174 1.3e-13 41.5 Pfam-A 1-141 (143) alignment 
Range on Protein: 19-174
Range on HMM: 1-141/143.0
VIVMVGLPARGKSFISRKLARYLNWIGVSTKVfslgdYRRRMLEgsqfdhsfF-----DpnnpNGMNIREECAKLVLADIVEWLkDKGKVAIFDATNSTR
....||||. |||. ...|.. | .. .|. .     .|||. .                   .  . .... . ... . . |  .|. .|.|||| .|
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg........tdqqslt....dytrvlkrlyqilnklarkal.sagrsvivdatnlsr

KRRETIIEKCQSYECRVMFLESVVDDPVIVKSNvmAVKISSPDYKGVQPEQACEDFLARIE
..|. ... .......|  .   |.. .. . .  | .  . |..   ||.| ...|||.|
eerarfvklakrlgvpvrivylevpeetlaeRl..akRerngddrsevpeealdrmlarfe
subfamily_PGAM_pd Subfamily PGAM 230-326 1.1e-10 33.2 In-house 3-107 (248) alignment 
Range on Protein: 230-326
Range on HMM: 3-107/248.0
IYLTRHGESEYNLKGRIGG--DSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKG------VSTEKWAALNEIDAGVCEGMTYEEIQE
. | ||||||.| . .. |  | .|| .|.   .|... . ...|.   |.||. ||..||.| |        . .|| . |||   |. .|.  .|. .
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaevak

NFPED
.. |.
kyGee
AAA_17 AAA domain 19-112 6.3e-09 27.3 Pfam-A 1-78 (121) alignment 
Range on Protein: 19-112
Range on HMM: 1-78/121.0
VIVMVGLPARGKSFISRKLARYLNWIgvstkVFSLGDY-RRRMLEGSQfdHSFFDPnnpngMNIREECAKLVLADIVEwlKDKGKVAIFDAtnsT
||. .| |. |||.....||..|...     |.||.|. |.. |.. .  . ...      ... ..  . .|... .  |..... ..|    .
viaitGppGsGKsTlakeLaerlglp.....vlslddllreeglkeld..dgeres.....kdadadllaaildglaa..kkdtlswvidg...a
subfamily_STS_pd Subfamily STS 248-381 4.5e-08 24.8 In-house 51-201 (245) alignment 
Range on Protein: 248-381
Range on HMM: 51-201/245.0
GDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKGVSTeKWAALnEIDAGVCEGMTYEEIQ-ENFP------EDFAKRDEDK--FHYR
 |. |. ||    . |.. . |....   .. | . |.|||.. |      | ... ... |..| . ... . ....      . | . |||   ..  
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkiki.kvepgllewlkldrkpipellspeelkkffpqidedYkpvlsl

Y--RRGESYEDLVARLEPVIMELERQH----NVLVVCHQAV----GRCLLAYF
.  ...||.|.|..| . |. |.  .     |.|.| | |     .|.|| . 
selkskeseeelyeRikkvvkeiiekvpedgniliVahaatldalsrqllgls
KTI12 Chromatin associated protein KTI12 20-146 3.3e-07 19.7 Pfam-A 4-116 (270) alignment 
Range on Protein: 20-146
Range on HMM: 4-116/270.0
IVMVGLPARGKSFISRKLARYLNWIGVSTKVFSLGDYRrrmlegsqFDHSFFDpNNPNGMNIREECAKLVLADIvewlkDKGKVAIFDATNSTRKRRETI
.|. |||. ||| ....||..|.  | |  | |  ...        .... .. .. .  ..|..  . |  |.     .| || | |..| ..  |  .
vvltGlPssGKstvakeLakaleeegrsvvvisdeslg........iekdsyk.dskkekalRsslrsavkrdL.....skekvVIvDslnYikgfRyeL

IEKCQSYECRVMFLESVVDDPVIVKSN
.  ..... ...  . |..  ..|| |
yclakeakttlcvvyvvapletlvkwn
Zeta_toxin Zeta toxin 16-133 6.1e-07 18.8 Pfam-A 15-128 (201) alignment 
Range on Protein: 16-133
Range on HMM: 15-128/201.0
VPVVIVMVGLPARGKSFISRKLARYLNwiGVSTKVFSLGDYRRRMlegSQFDHSFFDPNNPNGMNIREEcAKLVLADIVEWLKDKGKVAIFDATNSTRKR
 |......| |. ||. ....| . |.  . .. ...  ..|..     ....   .  . .    ... |  . . ..... .||.  |.. | .. . 
kpkavllgGqpGAGKtslaellleela..agnivridaDelrkfh...peyrelekkdpkeaseltqkd.aselveklidralekgyniilegtlrspdk

RETIIEKCQS--YECRVMFL
 . |..| ..  |.. |...
arkiarklkkagykvevviv
0053031 Phosphoglycerate mutase-like 228-291 2.9e-06 20.0 In-house 5-86 (342) alignment 
Range on Protein: 228-291
Range on HMM: 5-86/342.0
KAIYLTRHG----ESEYNLKGRI-----GGDSDLSHRGRLYGEKLAEFMAEQ---------KLQDFRVWTSEFKRTIQTTEH
..|.|.|||    .| ..|  ..      |...|...||.   .| ... .          . ....|..| . ||.|. . 
qvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqa
Cpn60_TCP1 TCP-1/cpn60 chaperonin family 58-141 3.9e-06 12.0 Pfam-A 172-259 (485) alignment 
Range on Protein: 58-141
Range on HMM: 172-259/485.0
RRMLEGSQFDHSFFDPNNPNGMnirEECAKLVLADIVEWLKD-KGKVAIFDA------TNSTRKRRETIIEKCQSYECRVMFLESVVDDPV
 ...|| ..|.... |. |. .   |..  |.| .  |. |. |.|| . ||      ... .|  . ..||. . .. . . .. .|| .
selieGvvldkgylspdmpkrl...enpkillldksleyeketktkvvlkdaeelekleeaeekqllpllekivesgvplviiakgiddea
subfamily_TFC7_pd Subfamily TFC7 229-377 8.5e-06 16.5 In-house 2-177 (255) alignment 
Range on Protein: 229-377
Range on HMM: 2-177/255.0
AIYLTRHGESEYNL-------KGR-IGGDSDLSHRGRLYGEKLAEFMAEQKLQDFRVWTSEFKRTIQTTEHIKGV-----ST----EKWAALNEIDaGVC
.||..|||  .  |         . |  |  ||.||    ..||... .  |.   . .| ..| ..|.. |               .|   ..    . 
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrP.vil

EGMTYEEIQENFPEdFAKRDEDKFHYRYRRGESYEDLVARLE---PVIM-----ELERQHNVLVVCHQAV----GRCL
| ...|...  ||.   ..| .       .||. |.|  |..   || .     . . .. .|.| | |     |. |
ePasnevlskffPs.visldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsl