Gene PFKFB-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP127_AA protein Get Run
NvecP127_AA_274-471 phosphatase_domain Get Run
Domains
Summary
100200300400MSQMSTSSVEQEIYDILTEEEEDDESFEEETPSENGAQRKPRLKRKNTITPSDYKYKVDCALPEYTPRFVNVPTVIVLVGLPARGKTYMAKKLGRYLNWIGIQCKVFNVGEYRRKAVGMDKLHDFFKVDNQEAQAIRRQCAIDCLNDVSSWLDEGVQAAIFDATNTTRERRRMVLDYCRRRGYKTFFMESVCNNSEIVASNIKEVKVFSPDYKEVDKEQAFNDFKERIKHYQAAYEPLTMEDGDLSFIKIINAGEQYLVNNIDGYLQSKSVYFLMNLHVRKRSIYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQHAPVEPWKALNEIDYGIYDGRPVSDLNTMGPDDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELERQNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAYGCRVERFPLEAPVSPASPEKHP1Curated phosphatase domainD6PF2KHis_Phos_1Pfam Domainsubfamily_PFKFB_pd(1)0039931(2)0035570(3)0053607(4)0049178(5)Subfamily
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 67-280 1.5e-89 289.2 Pfam-A 7-222 (223) alignment
subfamily_PFKFB_pd Subfamily PFKFB 276-471 4.5e-85 276.1 In-house 1-196 (198) alignment
0039931 Phosphoglycerate mutase-like 284-471 1.7e-51 167.0 In-house 2-188 (219) alignment
0035570 Phosphoglycerate mutase-like 284-466 9.4e-51 164.6 In-house 2-183 (219) alignment
0053607 Phosphoglycerate mutase-like 283-467 1.6e-47 153.7 In-house 3-186 (191) alignment
0049178 Phosphoglycerate mutase-like 282-468 1.4e-44 144.8 In-house 4-226 (243) alignment
0051064 Phosphoglycerate mutase-like 282-465 6e-44 143.1 In-house 4-225 (241) alignment
0037864 Phosphoglycerate mutase-like 275-467 1.2e-43 141.3 In-house 1-206 (211) alignment
0036777 Phosphoglycerate mutase-like 283-465 4.1e-43 140.1 In-house 4-226 (247) alignment
0043909 Phosphoglycerate mutase-like 282-465 4.2e-43 139.9 In-house 3-231 (249) alignment
0048955 Phosphoglycerate mutase-like 284-465 1.6e-42 138.3 In-house 3-222 (240) alignment
0036887 Phosphoglycerate mutase-like 283-467 1.1e-41 134.9 In-house 3-194 (202) alignment
0050036 Phosphoglycerate mutase-like 284-456 2.9e-38 123.1 In-house 3-165 (171) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 284-430 2e-31 102.1 Pfam-A 2-157 (158) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 284-430 2e-31 102.1 In-house 2-157 (158) alignment
subfamily_TIGAR_pd Subfamily TIGAR 283-417 2.4e-12 39.0 In-house 2-138 (222) alignment
AAA_33 AAA domain 75-227 8e-11 32.5 Pfam-A 1-139 (143) alignment
subfamily_PGAM_pd Subfamily PGAM 284-368 2.2e-10 32.2 In-house 3-95 (248) alignment
AAA_17 AAA domain 75-144 1.3e-08 26.2 Pfam-A 1-77 (121) alignment
KTI12 Chromatin associated protein KTI12 76-204 4.6e-07 19.2 Pfam-A 4-119 (270) alignment
subfamily_PGAM5_pd Subfamily PGAM5 282-357 4.3e-06 18.0 In-house 2-75 (189) alignment
subfamily_STS_pd Subfamily STS 303-432 4.9e-06 18.1 In-house 52-193 (245) alignment
Zeta_toxin Zeta toxin 72-184 8.5e-06 15.1 Pfam-A 15-122 (201) alignment