Gene TIGAR in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily TIGAR
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP128_AA protein Get Run
NvecP128_AA_20-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TIGAR_pd Subfamily TIGAR 22-289 6.5e-103 335.2 In-house 1-222 (222) alignment 
Range on Protein: 22-289
Range on HMM: 1-222/222.0
FSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEKFNYIFSSDLQRAYKTAEYILEVNKYKDGLAVTRDPRIKEKGYGIMEGKTKAEIH
|.|.|||||||..|. .|.||..||.||.||..|||.|||||..||.||||||||.||..|||.||...|.|...||.||.|..|..||..||....|..
filivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

DFLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGKIVHLQKKKRKcvdathrdeakdehmtsacseedsykkekathvistcsemdNGWEGEFTHVMS
..||..||..|||||||||||||..|.||...|||.||.||...|.|                                         .|.|||.|||..
ellkaagnvpsfvpegGesieqlelrlvaaleelcakilhleadkkk.........................................dgaegelthvlv

TCSTEDSHEGENVTHVISSAGGFQKNVGSRNNDIegsKSRNVynHPQNDGKQSHLGACAYGKETFNSA
........|..||.||..|.|......||||.|.   ....|  ....|||||...||.|.||..|..
vshglalrellnvlhvelsvgklrlakgsrntdl...stlvv..eierdgkqsvqvaclylkehlngl
0049178 Phosphoglycerate mutase-like 21-160 1.1e-39 128.9 In-house 3-171 (243) alignment 
Range on Protein: 21-160
Range on HMM: 3-171/243.0
SFSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKA
   |..||||||. |. ...||..|. |...|..||......|   . ||....||.|.||..|||.||| ....  | |..|||..| ..|..||.|||
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpl.lpvvvdprLrErdfGalegltka

EIHD-----FLKTFGNSHSFVP-----------------------EGGESIEQLYTRTVAFVNELCGKIV
||..     . . . ... ..|                        |||| .....| .....||. ...
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell
0043909 Phosphoglycerate mutase-like 23-158 8.8e-39 125.8 In-house 4-174 (249) alignment 
Range on Protein: 23-158
Range on HMM: 4-174/249.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEI
 |..||||||. |. ...||..|. |...|..||......|.  . .|....||.|.||..|||.||| ...   | |..|||..| ..|..||.|||||
rlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldk.lpvevdprLrErdfGalegltkaei

HDFLKTF-----G-----------------------------NSHSFVPEGGESIEQLYTRTVAFVNELCGK
..                                        .. .. | ||||..... | .....||. .
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellar
0036777 Phosphoglycerate mutase-like 23-158 2e-38 124.8 In-house 4-170 (247) alignment 
Range on Protein: 23-158
Range on HMM: 4-170/247.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAEI
 |..||||||. |. ...||..|. |...|..|||.....|..   .|....||.|.||..|||.|||  ..   | |..|||..| .||..||.|||||
rlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealgls.llpvvvdprLrErdyGalegltkaei

HDF-----LKTFGNSHSFVP-------------------------EGGESIEQLYTRTVAFVNELCGK
..       . . ... ..|                          ||||..... | .....||. .
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellar
0048955 Phosphoglycerate mutase-like 24-330 3.3e-38 124.3 In-house 3-196 (240) alignment 
Range on Protein: 24-330
Range on HMM: 3-196/240.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.. |. ...||..|  |...|..||. ...||.|   || ...||.|.||  |||.|.|  ...  | |. |||. |  .|..||.|..||.
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpl.lpvvvdprlrErdfgalegltldeia

DFLK-----TFGNSHSFVP-------------------------EGGESIEQLYTRTVAFVNELCGKivhlqkkkrkcvdathrdeakdehmtsacseed
. ..      . ..... |                          ||||..... | .|...||. .                                 
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellar.................................

sykkekathvistcsemdngwegefthvmstcstedshegenvthvissaggfqknvgsrnndiegsksrnvynhpqndgkqshlgacaygketfnsaan
                                                                                                    
....................................................................................................

lgnprapadltLSKPVSNVLMVVHGGTIRQLVQHFKRRV
             || .|||.| |||.|| |.... .. 
...........alkpgknvlvVsHggvirallayllglp
0037864 Phosphoglycerate mutase-like 22-158 1.7e-37 121.2 In-house 8-150 (211) alignment 
Range on Protein: 22-158
Range on HMM: 8-150/211.0
FSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAE
  |..||||||. |. ...||..|. |...|..||......|.|   .|....||.|.||..|||.|||. ..   | |..|||..|  .|..||.|..|
trlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglp.llpvevdprlrErdfgalegltlee

IHD-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGK
|..     . . . ... |.|.||||..... | .....||. .
iaekypeelvawlrdpydfrppggEsladvvaRvlpaleellar
0051064 Phosphoglycerate mutase-like 23-158 4.5e-36 117.3 In-house 5-171 (241) alignment 
Range on Protein: 23-158
Range on HMM: 5-171/241.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAEI
 |..|||||.. |. ...||..|. |...|..||. ...||.|   ||....||.|.||  |||.|.|  ...  | |. |||. |  .|..||.|..||
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglp.llpvvvdprlrEidfgalegltleei

H----DFLKTFGNSHSFVP--------------------------EGGESIEQLYTRTVAFVNELCGK
.    ..|  . ... .|.                           ||||..... | .....||. .
aekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellar
0036887 Phosphoglycerate mutase-like 24-158 7.5e-36 116.0 In-house 4-139 (202) alignment 
Range on Protein: 24-158
Range on HMM: 4-139/202.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEKFNYIFSSDLQRAYKTAEYILEVNkykdGLAVTRDPRIKEKGYGIMEGKTKAEIHD-
|..||||||. |. ...||..|. |...|..||. ...||.. .| ...||.|.||..|||.|.|.     || |..|||. |  .|..||.|..||.. 
lyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaeal....glpvivdprlrEidfgalegltleeiaek

----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGK
    . . . ... | | ||||..... | .|...||. .
ypeelaawlrdpydfrppggEsladvvaRvlaaleellar
0039931 Phosphoglycerate mutase-like 24-157 1.3e-35 115.1 In-house 2-132 (219) alignment 
Range on Protein: 24-157
Range on HMM: 2-132/219.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||. ...||.|   .| ...||.|.||..|||.|        || |..|||..| ..|..||.|..||.
lyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltleeia

-----DFLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCG
     .. . . ..  ..| ||||..... | .....||. 
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella
0035570 Phosphoglycerate mutase-like 24-160 1.5e-35 115.0 In-house 2-131 (219) alignment 
Range on Protein: 24-160
Range on HMM: 2-131/219.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||. ....|.|   .| ...||.|.||..|||.|        || |..|||..| ..|..||.|..||.
lyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltldeia

D-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELcgkiV
.     . . . ... ..| ||||..... | .....||     
ekypeelaawlrdpydyrppggEsladvvaRvlpaleel....e
0050036 Phosphoglycerate mutase-like 24-160 5.1e-35 112.6 In-house 3-129 (171) alignment 
Range on Protein: 24-160
Range on HMM: 3-129/171.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLqdeKFNYIFSSDLQRAYKTAEYILevnkykdgLAVTRDPRIKEKGYGIMEGKTKAEIHDF
|..||||||. |. ...||..|. |...|..||. ....|   .| ...||.|.||..|||.||        | |..|||..|  .|..||.|..||.. 
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell...pfdavysSpllRArqTaelil........lpvivdprLrErdfGawegltldeiaak

LKT-FGNSHSFVPEGGESIEQLYTRTVAFVNELCGKIV
    . . . ..| ||||......| .....||.| ..
ypewlldlldlappggEsladvlaRvlpaleellgnvl
0053607 Phosphoglycerate mutase-like 24-157 1.1e-34 112.0 In-house 4-134 (191) alignment 
Range on Protein: 24-157
Range on HMM: 4-134/191.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||...|..|.  . || ...||.|.||..|||.|        || |..|||..| ..|..||.|..|..
lyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii........glpvevdprlrEidfgdwegltleela

D-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCG
.     . . . ... ..| ||||......|......||. 
ekypeelaawlrdpldyrppggEsladvaaRvlpaleella
His_Phos_1 Histidine phosphatase superfamily (branch 1) 24-164 2.9e-32 104.8 Pfam-A 2-141 (158) alignment 
Range on Protein: 24-164
Range on HMM: 2-141/158.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKykdgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.  |. ...||.||. |..||..||. ..|.|.  |.... ...|.|.|| .|||..||. .    . ....||..|  .| .||..|.|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeevk

DFLK-----TFGNSHSFVPEGGESIEQLYTRTVAFVNELCGkivhLQK
. ..        ....| |..||| ...|.|. .|..||       ..
eefpeeyekwkrdkkefrppegesladvyeRvapfleelie....akd
His_Phos_1 Histidine phosphatase superfamily (branch 1) 24-164 2.9e-32 104.8 In-house 2-141 (158) alignment 
Range on Protein: 24-164
Range on HMM: 2-141/158.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKykdgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.  |. ...||.||. |..||..||. ..|.|.  |.... ...|.|.|| .|||..||. .    . ....||..|  .| .||..|.|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeevk

DFLK-----TFGNSHSFVPEGGESIEQLYTRTVAFVNELCGkivhLQK
. ..        ....| |..||| ...|.|. .|..||       ..
eefpeeyekwkrdkkefrppegesladvyeRvapfleelie....akd
subfamily_PGAM_pd Subfamily PGAM 24-129 1.1e-21 69.3 In-house 3-106 (248) alignment 
Range on Protein: 24-129
Range on HMM: 3-106/248.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEK--FNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEIh
| ..||||.  |  |...|. |. ||.|| ..|| ..| |....  |. ...|.|.|| .|.| |||  . .  . |... |..|. || ..|  |||. 
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqek.iPvektwrLnErhyGaltglnkaev.

dfLKTFGN
  .| .|.
..akkyGe
subfamily_PFKFB_pd Subfamily PFKFB 23-154 1.1e-12 39.9 In-house 8-136 (198) alignment 
Range on Protein: 23-154
Range on HMM: 8-136/198.0
SLWVVRHGETMENRLNIYQGHSDtvLSDKGIQQAKLVAKRLQDEKFN--YIFSSDLQRAYKTAEYIlevnK--YKDGLAvtrdprIKEKGYGIMEGKTKA
....|||||.. |  .   | |.  |...|...|| .|| ...|. .   ...| |.|. .|||..    .  ...  |      ..|   | ..| |  
eiylvRhGeseknkkgriggdse..LterGveyakklakfikeenlkelrvwtselkrtiqTaell....glpkeqwka......LdeldaGkcdgltye

EIHD-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNE
||..     | .   ... . . .|||.|.| .|    . |
eikekfpeefkerkkdkyryryprgEsyedlvqRlepvile
subfamily_STS_pd Subfamily STS 42-164 2.1e-09 29.1 In-house 49-176 (245) alignment 
Range on Protein: 42-164
Range on HMM: 49-176/245.0
GHSDTVLSDKGIQQAKLVAKRL--QDEKFNYIFSSDLQRAYKTAEYILEVNKykDGLAVTRDPRIKEKGYGIMEG-KTKAEIHD-------FLKTFGNSH
 .||. |.  |..||||....|  .. | ..||.|   |   ||. ||.  .  . ...  .| . |  .   .  .. .. ..         ...  ..
yksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg..kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvl

SFVP-EGGESIEQLYTRTVAFVNELCGKIvhlqK
|. . . .||.|.|| |. ..|.|.. |.    .
slselkskeseeelyeRikkvvkeiiekv....p
0047369 Phosphoglycerate mutase-like 24-87 2.7e-07 23.2 In-house 48-145 (438) alignment 
Range on Protein: 24-87
Range on HMM: 48-145/438.0
LWVVRHGE----------------T-------------MENRLNIYQGHsdTVLSDKGIQQAKLVAKRLQD-------EKFNYIFSSDLQRAYKTAEYIL
 ...|||.                              . |......|     |...|..||. . ||| .       |.. |..||| .|....|.. |
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcga..gqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqafl
0053031 Phosphoglycerate mutase-like 23-87 5.5e-07 22.4 In-house 6-88 (342) alignment 
Range on Protein: 23-87
Range on HMM: 6-88/342.0
SLWVVRHGET-------MENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ-----------DEKFNYIFSSDLQRAYKTAEYIL
  ..||||.        .. . . . . ..  |...|..||. . .||            . .  |..||| .|....|...|
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqafl
0049226 Phosphoglycerate mutase-like 24-87 5.9e-07 22.1 In-house 7-88 (342) alignment 
Range on Protein: 24-87
Range on HMM: 7-88/342.0
LWVVRHGE-------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDE-----------KFNYIFSSDLQRAYKTAEYIL
 ...|||.        .. . ... | ..  |...|..||  ...|| .            .  |..||| .|....|...|
qvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqafl
0046349 Phosphoglycerate mutase-like 24-87 8.6e-07 21.6 In-house 11-100 (409) alignment 
Range on Protein: 24-87
Range on HMM: 11-100/409.0
LWVVRHGE-----------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRL---------------QDEKFNYIFSSDLQRAYKTAEYIL
 ...|||.             ..  ... .  .  |...|..||  . |||                . .  |..||| .|....|...|
qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqafl
XRCC4 DNA double-strand break repair and V(D)J recombination protein XRCC4 137-210 8.8e-07 14.3 Pfam-A 173-245 (342) alignment 
Range on Protein: 137-210
Range on HMM: 173-245/342.0
GGESIE-QLYTRTVAFVNELCGKIVHLQKKKRKCVDATHrdEAKDEHMTSACSEEDSYKKEKATHVISTCSEMDN
| | .| .||.| .  .||   ||  |.|| ..  .. .  . |... .||.|.. . .  .  .  ||  | ..
gkealerdLykrfilvLnekkakirsLkkklsevqelek..slkkkkedsaasdkladeesvydyggstdeeqea
subfamily_PGAM5_pd Subfamily PGAM5 24-88 1.3e-06 19.7 In-house 4-65 (189) alignment 
Range on Protein: 24-88
Range on HMM: 4-65/189.0
LWVVRHGETMENrlniyQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILE
| .||||. ...     .   . .|...| .||.|. |||..   ||. . .| . ||  ||. |..
lilvrhgqyvld.....ddsdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiisk
0049059 Phosphoglycerate mutase-like 25-87 1.3e-06 20.8 In-house 48-144 (435) alignment 
Range on Protein: 25-87
Range on HMM: 48-144/435.0
WVVRHGE---------TMEN-----------------RLNIYQ-GHSDTVLSDKGIQQAKLVAKRLQD-------EKFNYIFSSDLQRAYKTAEYIL
 ..|||.         ..|                  .|| ..    .  |...|..||.  .||| .        .  |..||| .|....|.. |
vlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl
0048439 Phosphoglycerate mutase-like 25-87 8.2e-06 18.5 In-house 14-103 (391) alignment 
Range on Protein: 25-87
Range on HMM: 14-103/391.0
WVVRHGE------------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ---------------DEKFNYIFSSDLQRAYKTAEYIL
 ..|||.             . |.|  . .  .  |...|..|.    .||                . .  |..||| .|....|.. |
vlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqafl