Gene TIGAR in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily TIGAR
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP128_AA protein Get Run
NvecP128_AA_20-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TIGAR_pd Subfamily TIGAR 22-289 6.5e-103 335.2 In-house 1-222 (222) alignment
Range on Protein: 22-289
Range on HMM: 1-222/222.0
FSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEKFNYIFSSDLQRAYKTAEYILEVNKYKDGLAVTRDPRIKEKGYGIMEGKTKAEIH
|.|.|||||||..|. .|.||..||.||.||..|||.|||||..||.||||||||.||..|||.||...|.|...||.||.|..|..||..||....|..
filivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

DFLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGKIVHLQKKKRKcvdathrdeakdehmtsacseedsykkekathvistcsemdNGWEGEFTHVMS
..||..||..|||||||||||||..|.||...|||.||.||...|.|                                         .|.|||.|||..
ellkaagnvpsfvpegGesieqlelrlvaaleelcakilhleadkkk.........................................dgaegelthvlv

TCSTEDSHEGENVTHVISSAGGFQKNVGSRNNDIegsKSRNVynHPQNDGKQSHLGACAYGKETFNSA
........|..||.||..|.|......||||.|.   ....|  ....|||||...||.|.||..|..
vshglalrellnvlhvelsvgklrlakgsrntdl...stlvv..eierdgkqsvqvaclylkehlngl

0049178 Phosphoglycerate mutase-like 21-160 1.1e-39 128.9 In-house 3-171 (243) alignment
Range on Protein: 21-160
Range on HMM: 3-171/243.0
SFSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKA
   |..||||||. |. ...||..|. |...|..||......|   . ||....||.|.||..|||.||| ....  | |..|||..| ..|..||.|||
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpl.lpvvvdprLrErdfGalegltka

EIHD-----FLKTFGNSHSFVP-----------------------EGGESIEQLYTRTVAFVNELCGKIV
||..     . . . ... ..|                        |||| .....| .....||. ...
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell

0043909 Phosphoglycerate mutase-like 23-158 8.8e-39 125.8 In-house 4-174 (249) alignment
Range on Protein: 23-158
Range on HMM: 4-174/249.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEI
 |..||||||. |. ...||..|. |...|..||......|.  . .|....||.|.||..|||.||| ...   | |..|||..| ..|..||.|||||
rlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldk.lpvevdprLrErdfGalegltkaei

HDFLKTF-----G-----------------------------NSHSFVPEGGESIEQLYTRTVAFVNELCGK
..                                        .. .. | ||||..... | .....||. .
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellar

0036777 Phosphoglycerate mutase-like 23-158 2e-38 124.8 In-house 4-170 (247) alignment
Range on Protein: 23-158
Range on HMM: 4-170/247.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAEI
 |..||||||. |. ...||..|. |...|..|||.....|..   .|....||.|.||..|||.|||  ..   | |..|||..| .||..||.|||||
rlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealgls.llpvvvdprLrErdyGalegltkaei

HDF-----LKTFGNSHSFVP-------------------------EGGESIEQLYTRTVAFVNELCGK
..       . . ... ..|                          ||||..... | .....||. .
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellar

0048955 Phosphoglycerate mutase-like 24-330 3.3e-38 124.3 In-house 3-196 (240) alignment
Range on Protein: 24-330
Range on HMM: 3-196/240.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.. |. ...||..|  |...|..||. ...||.|   || ...||.|.||  |||.|.|  ...  | |. |||. |  .|..||.|..||.
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpl.lpvvvdprlrErdfgalegltldeia

DFLK-----TFGNSHSFVP-------------------------EGGESIEQLYTRTVAFVNELCGKivhlqkkkrkcvdathrdeakdehmtsacseed
. ..      . ..... |                          ||||..... | .|...||. .                                 
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellar.................................

sykkekathvistcsemdngwegefthvmstcstedshegenvthvissaggfqknvgsrnndiegsksrnvynhpqndgkqshlgacaygketfnsaan
                                                                                                    
....................................................................................................

lgnprapadltLSKPVSNVLMVVHGGTIRQLVQHFKRRV
             || .|||.| |||.|| |.... .. 
...........alkpgknvlvVsHggvirallayllglp

0037864 Phosphoglycerate mutase-like 22-158 1.7e-37 121.2 In-house 8-150 (211) alignment
Range on Protein: 22-158
Range on HMM: 8-150/211.0
FSLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAE
  |..||||||. |. ...||..|. |...|..||......|.|   .|....||.|.||..|||.|||. ..   | |..|||..|  .|..||.|..|
trlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglp.llpvevdprlrErdfgalegltlee

IHD-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGK
|..     . . . ... |.|.||||..... | .....||. .
iaekypeelvawlrdpydfrppggEsladvvaRvlpaleellar

0051064 Phosphoglycerate mutase-like 23-158 4.5e-36 117.3 In-house 5-171 (241) alignment
Range on Protein: 23-158
Range on HMM: 5-171/241.0
SLWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILEVNKYKdGLAVTRDPRIKEKGYGIMEGKTKAEI
 |..|||||.. |. ...||..|. |...|..||. ...||.|   ||....||.|.||  |||.|.|  ...  | |. |||. |  .|..||.|..||
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglp.llpvvvdprlrEidfgalegltleei

H----DFLKTFGNSHSFVP--------------------------EGGESIEQLYTRTVAFVNELCGK
.    ..|  . ... .|.                           ||||..... | .....||. .
aekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellar

0036887 Phosphoglycerate mutase-like 24-158 7.5e-36 116.0 In-house 4-139 (202) alignment
Range on Protein: 24-158
Range on HMM: 4-139/202.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEKFNYIFSSDLQRAYKTAEYILEVNkykdGLAVTRDPRIKEKGYGIMEGKTKAEIHD-
|..||||||. |. ...||..|. |...|..||. ...||.. .| ...||.|.||..|||.|.|.     || |..|||. |  .|..||.|..||.. 
lyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaeal....glpvivdprlrEidfgalegltleeiaek

----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCGK
    . . . ... | | ||||..... | .|...||. .
ypeelaawlrdpydfrppggEsladvvaRvlaaleellar

0039931 Phosphoglycerate mutase-like 24-157 1.3e-35 115.1 In-house 2-132 (219) alignment
Range on Protein: 24-157
Range on HMM: 2-132/219.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||. ...||.|   .| ...||.|.||..|||.|        || |..|||..| ..|..||.|..||.
lyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltleeia

-----DFLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCG
     .. . . ..  ..| ||||..... | .....||. 
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella

0035570 Phosphoglycerate mutase-like 24-160 1.5e-35 115.0 In-house 2-131 (219) alignment
Range on Protein: 24-160
Range on HMM: 2-131/219.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||. ....|.|   .| ...||.|.||..|||.|        || |..|||..| ..|..||.|..||.
lyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii........glpveidprLrEidfgdlegltldeia

D-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELcgkiV
.     . . . ... ..| ||||..... | .....||     
ekypeelaawlrdpydyrppggEsladvvaRvlpaleel....e

0050036 Phosphoglycerate mutase-like 24-160 5.1e-35 112.6 In-house 3-129 (171) alignment
Range on Protein: 24-160
Range on HMM: 3-129/171.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLqdeKFNYIFSSDLQRAYKTAEYILevnkykdgLAVTRDPRIKEKGYGIMEGKTKAEIHDF
|..||||||. |. ...||..|. |...|..||. ....|   .| ...||.|.||..|||.||        | |..|||..|  .|..||.|..||.. 
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell...pfdavysSpllRArqTaelil........lpvivdprLrErdfGawegltldeiaak

LKT-FGNSHSFVPEGGESIEQLYTRTVAFVNELCGKIV
    . . . ..| ||||......| .....||.| ..
ypewlldlldlappggEsladvlaRvlpaleellgnvl

0053607 Phosphoglycerate mutase-like 24-157 1.1e-34 112.0 In-house 4-134 (191) alignment
Range on Protein: 24-157
Range on HMM: 4-134/191.0
LWVVRHGETMENRLNIYQGhsDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYIlevnkykdGLAVTRDPRIKEKGYGIMEGKTKAEIH
|..||||||. |. ...||  |. |...|..||...|..|.  . || ...||.|.||..|||.|        || |..|||..| ..|..||.|..|..
lyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii........glpvevdprlrEidfgdwegltleela

D-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNELCG
.     . . . ... ..| ||||......|......||. 
ekypeelaawlrdpldyrppggEsladvaaRvlpaleella

His_Phos_1 Histidine phosphatase superfamily (branch 1) 24-164 2.9e-32 104.8 Pfam-A 2-141 (158) alignment
Range on Protein: 24-164
Range on HMM: 2-141/158.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKykdgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.  |. ...||.||. |..||..||. ..|.|.  |.... ...|.|.|| .|||..||. .    . ....||..|  .| .||..|.|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeevk

DFLK-----TFGNSHSFVPEGGESIEQLYTRTVAFVNELCGkivhLQK
. ..        ....| |..||| ...|.|. .|..||       ..
eefpeeyekwkrdkkefrppegesladvyeRvapfleelie....akd

His_Phos_1 Histidine phosphatase superfamily (branch 1) 24-164 2.9e-32 104.8 In-house 2-141 (158) alignment
Range on Protein: 24-164
Range on HMM: 2-141/158.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ--DEKFNYIFSSDLQRAYKTAEYILEVNKykdgLAVTRDPRIKEKGYGIMEGKTKAEIH
|..|||||.  |. ...||.||. |..||..||. ..|.|.  |.... ...|.|.|| .|||..||. .    . ....||..|  .| .||..|.|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld....ipiikeprLrerdfgeweglpkeevk

DFLK-----TFGNSHSFVPEGGESIEQLYTRTVAFVNELCGkivhLQK
. ..        ....| |..||| ...|.|. .|..||       ..
eefpeeyekwkrdkkefrppegesladvyeRvapfleelie....akd

subfamily_PGAM_pd Subfamily PGAM 24-129 1.1e-21 69.3 In-house 3-106 (248) alignment
Range on Protein: 24-129
Range on HMM: 3-106/248.0
LWVVRHGETMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDEK--FNYIFSSDLQRAYKTAEYILEVNKYKDgLAVTRDPRIKEKGYGIMEGKTKAEIh
| ..||||.  |  |...|. |. ||.|| ..|| ..| |....  |. ...|.|.|| .|.| |||  . .  . |... |..|. || ..|  |||. 
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqek.iPvektwrLnErhyGaltglnkaev.

dfLKTFGN
  .| .|.
..akkyGe

subfamily_PFKFB_pd Subfamily PFKFB 23-154 1.1e-12 39.9 In-house 8-136 (198) alignment
Range on Protein: 23-154
Range on HMM: 8-136/198.0
SLWVVRHGETMENRLNIYQGHSDtvLSDKGIQQAKLVAKRLQDEKFN--YIFSSDLQRAYKTAEYIlevnK--YKDGLAvtrdprIKEKGYGIMEGKTKA
....|||||.. |  .   | |.  |...|...|| .|| ...|. .   ...| |.|. .|||..    .  ...  |      ..|   | ..| |  
eiylvRhGeseknkkgriggdse..LterGveyakklakfikeenlkelrvwtselkrtiqTaell....glpkeqwka......LdeldaGkcdgltye

EIHD-----FLKTFGNSHSFVPEGGESIEQLYTRTVAFVNE
||..     | .   ... . . .|||.|.| .|    . |
eikekfpeefkerkkdkyryryprgEsyedlvqRlepvile

subfamily_STS_pd Subfamily STS 42-164 2.1e-09 29.1 In-house 49-176 (245) alignment
Range on Protein: 42-164
Range on HMM: 49-176/245.0
GHSDTVLSDKGIQQAKLVAKRL--QDEKFNYIFSSDLQRAYKTAEYILEVNKykDGLAVTRDPRIKEKGYGIMEG-KTKAEIHD-------FLKTFGNSH
 .||. |.  |..||||....|  .. | ..||.|   |   ||. ||.  .  . ...  .| . |  .   .  .. .. ..         ...  ..
yksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg..kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvl

SFVP-EGGESIEQLYTRTVAFVNELCGKIvhlqK
|. . . .||.|.|| |. ..|.|.. |.    .
slselkskeseeelyeRikkvvkeiiekv....p

0047369 Phosphoglycerate mutase-like 24-87 2.7e-07 23.2 In-house 48-145 (438) alignment
Range on Protein: 24-87
Range on HMM: 48-145/438.0
LWVVRHGE----------------T-------------MENRLNIYQGHsdTVLSDKGIQQAKLVAKRLQD-------EKFNYIFSSDLQRAYKTAEYIL
 ...|||.                              . |......|     |...|..||. . ||| .       |.. |..||| .|....|.. |
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcga..gqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqafl





0053031 Phosphoglycerate mutase-like 23-87 5.5e-07 22.4 In-house 6-88 (342) alignment
Range on Protein: 23-87
Range on HMM: 6-88/342.0
SLWVVRHGET-------MENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ-----------DEKFNYIFSSDLQRAYKTAEYIL
  ..||||.        .. . . . . ..  |...|..||. . .||            . .  |..||| .|....|...|
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqafl

0049226 Phosphoglycerate mutase-like 24-87 5.9e-07 22.1 In-house 7-88 (342) alignment
Range on Protein: 24-87
Range on HMM: 7-88/342.0
LWVVRHGE-------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQDE-----------KFNYIFSSDLQRAYKTAEYIL
 ...|||.        .. . ... | ..  |...|..||  ...|| .            .  |..||| .|....|...|
qvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqafl

0046349 Phosphoglycerate mutase-like 24-87 8.6e-07 21.6 In-house 11-100 (409) alignment
Range on Protein: 24-87
Range on HMM: 11-100/409.0
LWVVRHGE-----------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRL---------------QDEKFNYIFSSDLQRAYKTAEYIL
 ...|||.             ..  ... .  .  |...|..||  . |||                . .  |..||| .|....|...|
qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqafl

XRCC4 DNA double-strand break repair and V(D)J recombination protein XRCC4 137-210 8.8e-07 14.3 Pfam-A 173-245 (342) alignment
Range on Protein: 137-210
Range on HMM: 173-245/342.0
GGESIE-QLYTRTVAFVNELCGKIVHLQKKKRKCVDATHrdEAKDEHMTSACSEEDSYKKEKATHVISTCSEMDN
| | .| .||.| .  .||   ||  |.|| ..  .. .  . |... .||.|.. . .  .  .  ||  | ..
gkealerdLykrfilvLnekkakirsLkkklsevqelek..slkkkkedsaasdkladeesvydyggstdeeqea

subfamily_PGAM5_pd Subfamily PGAM5 24-88 1.3e-06 19.7 In-house 4-65 (189) alignment
Range on Protein: 24-88
Range on HMM: 4-65/189.0
LWVVRHGETMENrlniyQGHSDTVLSDKGIQQAKLVAKRLQD--EKFNYIFSSDLQRAYKTAEYILE
| .||||. ...     .   . .|...| .||.|. |||..   ||. . .| . ||  ||. |..
lilvrhgqyvld.....ddsdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiisk

0049059 Phosphoglycerate mutase-like 25-87 1.3e-06 20.8 In-house 48-144 (435) alignment
Range on Protein: 25-87
Range on HMM: 48-144/435.0
WVVRHGE---------TMEN-----------------RLNIYQ-GHSDTVLSDKGIQQAKLVAKRLQD-------EKFNYIFSSDLQRAYKTAEYIL
 ..|||.         ..|                  .|| ..    .  |...|..||.  .||| .        .  |..||| .|....|.. |
vlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl

0048439 Phosphoglycerate mutase-like 25-87 8.2e-06 18.5 In-house 14-103 (391) alignment
Range on Protein: 25-87
Range on HMM: 14-103/391.0
WVVRHGE------------TMENRLNIYQGHSDTVLSDKGIQQAKLVAKRLQ---------------DEKFNYIFSSDLQRAYKTAEYIL
 ..|||.             . |.|  . .  .  |...|..|.    .||                . .  |..||| .|....|.. |
vlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqafl