Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
PHP | 11-125 | 1.2e-49 | 157.3 | In-house | 2-121 (121) | alignment | |||
Range on Protein: 11-125
Range on HMM: 2-121/121.0
KLDAIPDVDIDESGIFKYILLKITD------GDKEKNIVRGYEWADFHADIYERVQPGIEELGLGTECVGGGRIRHNAAKKKILVYGFSMGFGRADHKIS
.|...||||||. |.|||.|...|. ....|..||||..|..|||||.||. .|. || .||.|||||.|. .||| |||.|.|.|.|||...
elakvpdvdidpeGvfkyvlirvtskerkdgaaaskevvrGyaraeyhadiydrvsselekqgldaeclGGGriehdseekkikvyGysvgyGkadhavt
VAKLKAVYPNYtEITFSNDGY
. |||. ||.| |||.|..||
keklktkyPdy.eitlsdeGy
|
|||||||||
subfamily_PHP_pd | Subfamily PHP | 13-123 | 9.4e-48 | 150.8 | In-house | 2-114 (114) | alignment | ||
Range on Protein: 13-123
Range on HMM: 2-114/114.0
DAIPDVDIDESGIFKYILLKI---TDGDKEKNIVRGYEWADFHADIYERVQPGIEELGLGTECVGGGRIRHNAAKKKILVYGFSMGFGRADHKISVAKLK
.|.|.||||..| |||.|... ..|.|.|.|||||..|..||||||.|.. .|.||| ..|.|||||.|.. |||| |||.|.|||.|||.|.. .||
aavpevdidskGkfkYvlielttdsegkksktivrgyskaeyhadiyeevkeeleklglkakclGGGriehdkekkkikvyGyskgfGkadheiakeilk
AVYPNYtEITFSND
..||.| .||.||.
tkypdy.kitisne
|
|||||||||
Ocnus | Janus/Ocnus family (Ocnus) | 12-116 | 5.6e-43 | 135.1 | Pfam-A | 1-107 (108) | alignment | ||
Range on Protein: 12-116
Range on HMM: 1-107/108.0
LDAIPDVDIDESGIFKYILLKITD--GDKEKNIVRGYEWADFHADIYERVQPGIEELGLGTECVGGGRIRHNAAKKKILVYGFSMGFGRADHKISVAKLK
|...|.|||||.|.|||.|.|... .|..|..|||...|..||||||.|. .|.||| |||.|||||.|...|||| ||| |.|||.|||.|....||
LakvpevdideeGkfkYvlikvkikekdeskevvrglkkaeyHadiyekvkkeleklgleteclGGGriehdeekkkikvyGyskgfGkadheiakeilk
AVYPNYT
. |..|.
kkykdye
|
|||||||||
Ocnus | Janus/Ocnus family (Ocnus) | 12-116 | 5.6e-43 | 135.1 | In-house | 1-107 (108) | alignment | ||
Range on Protein: 12-116
Range on HMM: 1-107/108.0
LDAIPDVDIDESGIFKYILLKITD--GDKEKNIVRGYEWADFHADIYERVQPGIEELGLGTECVGGGRIRHNAAKKKILVYGFSMGFGRADHKISVAKLK
|...|.|||||.|.|||.|.|... .|..|..|||...|..||||||.|. .|.||| |||.|||||.|...|||| ||| |.|||.|||.|....||
LakvpevdideeGkfkYvlikvkikekdeskevvrglkkaeyHadiyekvkkeleklgleteclGGGriehdeekkkikvyGyskgfGkadheiakeilk
AVYPNYT
. |..|.
kkykdye
|
|||||||||
0053050 | PHP14-like | 12-116 | 2.1e-42 | 132.9 | In-house | 2-113 (118) | alignment | ||
Range on Protein: 12-116
Range on HMM: 2-113/118.0
LDAIPDVDIDESGIFKYILLKIT-------DGDKEKNIVRGYEWADFHADIYERVQPGIEELGLGTECVGGGRIRHNAAKKKILVYGFSMGFGRADHKIS
| ..|.|||||.|.|||.|.|.| .|...| ||||. .|..||||||.|.. .|.||| .||.|||||.|. |||| |||.|.|||.|||.|.
lakvpevdideeGvfkYvlikvtlkgltdsggkesklivrglkkaeyHadiyeevskeleklgldleclGGGriehdsekkkikvyGyslgfGkadheia
VAKLKAVYPNYT
...|| .||.|.
leilktkypdye
|