Gene PDP-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PDPc
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP138_AA protein Get Run
NvecP138_AA_105-497 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PDP_pd Subfamily PDP 107-498 3.6e-160 526.4 In-house 1-398 (398) alignment
Range on Protein: 107-498
Range on HMM: 1-398/398.0
ETNQLASNQPMEDRKFVVRLLHQDgGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPDLMPKLTDYLTITKNEDHCYNYANDPACRNSLNK
..||||||.|.|||.....||... |.||||.|||||.|||..|.|||..|.|.|||...|| .. . ... ...|...|...|......| |...||..
dsnqLasNePiEDrrseakllesn.gvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslse

YFYELQDMVEAHVEMHVRSIREAYIRLDQDIRNEAVKESksklPEGSSCHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGCWSAMQLSSD
. ..||...||.||.. .....|. .||.||..||.|..    .| |...|...| .|||||.|.|.||||..||.|||||||||| |.|.|.|..||.|
lskylqelleaevekvkealkkaFlklDkdistealkkl....kekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskd

HTAGNPEEVQRILNQHPPEESTTVIRFERLLGRLAPLRAFGDARFKWDKKTQNKVYSKSSlNPMSEVEHFYTPPYLTAEPEVMSYQLQRTDKFLVLATDG
.|| |.|||.|| ..|| |||.|||| .||||.|.|||||||.|.||....|.||..|.. ....|.....|||||||||||.|..|...||||||||||
qtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekay.lkvlepkdyktPPYltaePevtshklrendkFLvlatDG

LWDMLSNEEVVHYVQEHVCKKVEDTSKGVLPQDITFN-----EQELPCDL----NNAASCLVREALGGD---DHVAVSTTLSIPYPDVRMYRDDISVIVV
|||.|||||||..|.||..|| |... .| ....|..     ..|  ..|    .|||..|.|.||||.   |. .||..||||.. .|||||||.|.||
LwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkredknaAthLirhalggneagdkekvsallsiPeelaRmyRDDitvtVv

FFNW
|||.
ffns

PP2Cc_SM00332 106-494 4.5e-61 199.6 In-house 14-274 (274) alignment
Range on Protein: 106-494
Range on HMM: 14-274/274.0
YeTNQLASNQPMEDRKFVVRLL-HQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLahpdlmpkltdyltitknedhcynyandpacrnsl
. ...  ....|||. .||  | ..... .||| |||||...|  |.|.||.... .|      |                                   
k.ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...................................

nkyfyelqdmveahVEMHVRSIREAYIRLDQDIRNEAVKESKSKlpegsschafdaANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLS
               ..  . ...|. ..|..|. |. .. . .            |..|..|.||....  |..||.||.||||. .|.     | |||
..............eddveealkkaflstdeeileeeqskelen............alsGstavvallkkedlyvanvGDSravlcrngk.....avqls

SDHTAGNPEEVQRILNQHPpeesttVIRFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehFYTPPYLTAEPEVMSYQLQRTDKFLVLAT
 ||.. ...|..|| ....      |....|. | ||  |||||  .|. |                      ..||.||||.|   .|   |.||.||.
vdhkpedederkRikkagg......vvekgrvngglavsrafGdhflkknk....................klkepyitaepdvkvvtltsedeflilaS

DGLWDMLSNEEVVHYVQEHVCKKvedtskgvlpqditfneqeLPCDLNNAASCLVREALGGddhvavsttlsipypdvRMYRDDISVIVV
|||||.|||.||| .|...  |.                      |  .||  |..||.                   ....|.|.|.||
DGlwdvlsnqevvdivrkllakg...................ktndpqeaaelldeeairr.................ggseDniTvvvv

0034914 PP2C-like 114-497 2.4e-59 193.5 In-house 32-291 (295) alignment
Range on Protein: 114-497
Range on HMM: 32-291/295.0
NQPMEDRKFVVRLL--HQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPdlmpkltdyltitknedhcynyandpacrnslnkyfyel
. ..||. .||. |  ......|||| ||||| |.|. ....|.....  | . ..|| ..                                       
rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.......................................

qdmveahVEMHVRSIREAYIRLDQDIRNEAVKEsksklpegsschaFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGN
        |. ....|.|....|......|...              . |. |..|.||.|.|. |..||.||.||||  .|      ..||. ||.  |
.......ledieealrkaflaadeellelallr.............pelagsGtTavvalirgnklyvanvGDSravllrng.....elvqltvdhkpvn

PEEVQRILNQHPpeesttVIRFERLLGRLAPLRAFGDARFKWDKKTqnkvysksslnpmsevehFYTPPYLTAEPEVMSYQLQ-RTDKFLVLATDGLWDM
..|..|||. ..      .....|..| ||  ||.|| ..|. ..                   ....|...|||.|....|.   |.||.||.|||||.
elererilsagg......avshgrvngvlavtRalGdfdlklllsl..................llleplvsaePdvtvleltledddfllLasDGlwdv

LSNEEVVHYVQEHVCKKVEdtskgvlpqditfneqelpcdLNNAASCLVREALGgddhvavsttlsipypdvRMYRDDISVIVVFFN
|||||.|..|.... |  .                     |..||  ||..||                   |..||.|.|.||..|
lsneeivdivrsllakgld.....................leeaaeeLvdlAla..................rgsrDNiTvvvvrln

PP2C Protein phosphatase 2C 210-427 6.7e-41 133.5 Pfam-A 47-232 (255) alignment
Range on Protein: 210-427
Range on HMM: 47-232/255.0
ELQDMVEAHVEMHVRSIREAYIR-LDQDIRNEAVKE-SKSKLPEgSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDH
|.... . |.| .. . .. .   ..... .... .  ...|   |....    . |..|.||.|.|..|..||.||.||||. ....      .|. ||
eaakyarehleeilkeqksflelekvekalrksfladtdeelks.skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedH

TAGNPEEVQRILNQHPPEESttvirFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehfytPPYLTAEPEVMSYQLQRTDKFLVLATDGL
.. ...|..|| ...   .      . |. | ||  ||.|| ..| ..                       ... .|||.| | .|.. |.||.||.|||
kpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.......................eqlvsaePdvtsvklteedefliLasdGl

WDMLSNEEVVHYVQEHVCKK
||.||..|.|. |.... ||
wdvlsdqeavdlvrselskk

PP2C Protein phosphatase 2C 210-427 6.7e-41 133.5 In-house 47-232 (255) alignment
Range on Protein: 210-427
Range on HMM: 47-232/255.0
ELQDMVEAHVEMHVRSIREAYIR-LDQDIRNEAVKE-SKSKLPEgSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDH
|.... . |.| .. . .. .   ..... .... .  ...|   |....    . |..|.||.|.|..|..||.||.||||. ....      .|. ||
eaakyarehleeilkeqksflelekvekalrksfladtdeelks.skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedH

TAGNPEEVQRILNQHPPEESttvirFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehfytPPYLTAEPEVMSYQLQRTDKFLVLATDGL
.. ...|..|| ...   .      . |. | ||  ||.|| ..| ..                       ... .|||.| | .|.. |.||.||.|||
kpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.......................eqlvsaePdvtsvklteedefliLasdGl

WDMLSNEEVVHYVQEHVCKK
||.||..|.|. |.... ||
wdvlsdqeavdlvrselskk

0049733 PP2C-like 114-497 4.1e-40 130.6 In-house 15-234 (235) alignment
Range on Protein: 114-497
Range on HMM: 15-234/235.0
NQPMEDRKFVvrllhqdGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHrhvlL---Ahpdlmpkltdyltitknedhcynyandpacrnslnkyfye
.. .||. .|       |..||.| ||||| |... . ..|.....  ||.    |                                            
rkvneDavlv.......glllfavaDGhgghaagevasellvetllellle....lllld........................................

lqdmveahvemHVRSIREAYIRLDQDIRNEAVKESksklpegsschafDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAG
            ....|.|. .... ....|...              . |  |..|.||...|  |..||.||.||.|  .|.     ..||. ||.  
...........leealrkaflaaneallelalasp.............elagmgtTavvalldggklyvanvGDsrayllrdgk.....lvqltedhspv

NPEEVQRILNQHPPEesttvirfeRLLGRLAPLRAFGDARFKwdkktqnkvysksslnpmsevehfytppyltaePEVMSYQLQRTDkFLVLATDGLWDM
|..|.|||.. ..           | .|||| .||.||  .|                                 |.|....|.  | ||.||.|||||.
nelerqriitaggav.........rvpgrlaltralGdlllk.................................pdvtvlelepgd.flllasDGlwdv

LSNEEVVHYVQEhvckkveD-TskgvlpqditfneqelpcdlNNAASCLVREALGgddhvavsttlsipypdvRMYRDDISVIVVFFN
||.||.|.....       .                      ..||..||..||                   |  ||.|.|.||...
lsdeeivdllrs.......ldl....................eeaaerlvelala..................rggrDNiTvvvvrld

PPM_PTC7 225-427 4.4e-39 127.5 In-house 75-237 (259) alignment
Range on Protein: 225-427
Range on HMM: 75-237/259.0
SIREAYIRLDQDIRNEAvkesksklpegSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDHTAGNPEEVQRILNQHPP
 .|... .||.|....            |....    . |..|.||.|.|..|. ||.||.||||. .|..      ||. ||.. |..|..|| . .  
alrksflaldtdeelks...........seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRiegaggs

EESTtviRFERLLGRLAPLRAFGDARFKWDKKtqnkvysksslnpmsevehfyTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHV
 ..    .. |. | ||  ||||| ..| ...                     ......|||.. | ...  |.||.||.|||||..|..|.|. |....
vsnv...gngrvngvlavsRafGdfelkpket.....................eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrsel

CKK
 ||
skk

subfamily_PPM1A_pd Subfamily PPM1A 115-497 1.4e-37 122.6 In-house 24-281 (282) alignment
Range on Protein: 115-497
Range on HMM: 24-281/282.0
QPMEDRKFVVRLLHQD-GGYLFGVMDGHGGNACAHNVCKRLPDYIALsllhrhvllahpdlmpkltdyltitknedhcynyandpacrnslNKYFYElQD
. |||.  ||  | .  .. .| |.|||.|. .|. | | |.. |                                              .. . | . 
vemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile............................................eeelke.aa

MVEAHVEMHVRSIREAYIRLDQDIRNEAVKESKS-KLpegsschafdaanaGACALVAYIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGNP
. . . . .   .|.....||..||..  . ... |               |. |... .. ..|..||.||.||||  .|     .|. |..|| . .|
leasekdevkealrqgfLaldeairelstdlktadks..............GsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrp

EEVQRIlnqhppEESTTVIRFERLLGRLAPLRAFGDARFKWDKKTQNKvysKSslnpmsEvehfytppyLTAEPEVMSYQLQRTDKFLVLATDGLWDMLS
.| .||      |.    .  .|. | ||  ||.||  .| ... ...   .                 ..|||||.| . .  |.||||| ||.||.||
kEkkRi......eqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkae...eq......l.........vsaepevtsierseeddflvlacDGiwDvls

NEEVVHYVQEHVCKKvEDTSKGvlpqditfneqelpcdlnnaasclvrealggddhvaVSTTLSIPYpdVRMYRDDISVIVVFFN
.||||..|.... .. .. ..                                     ... .   .   .  || .||.||.|.
deevvelvrkrleva.deleev....................................akalvdkal..ekgsrDNlsvlvvlfa

subfamily_PPM1G2_pd Subfamily PPM1G2 126-429 1.8e-34 112.0 In-house 46-252 (287) alignment
Range on Protein: 126-429
Range on HMM: 46-252/287.0
LLHQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALsllhrhvllahpdlmpkltdyltitknedhcynyandpacrnslnkyfyelqdmveahvE-----
.  ..   ||.|.|||||...|. . |.|  .||                                                                  
ksddkslalfavfDGhGGakvakyagkklikkiak...........................................................kksfke

-MHVRSIREAYIRLDQDIRNEavkesksklpegsscHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAGNPEEVQRIL
 .  . ...|....|......               ....  .||. |.|. |. ..|. ||||| |||| ..|.     . .|| ||   . .| .|| 
galeqilkdafletDeellkd...............eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkrii

NqhppeeSTTVIRFERLLGRLAPLRAFGDARFKWDKKtqnkvysksslnpmsevehfyTP---PYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEV
.      .  .. ..|  | ||  ||.||  ||  .|                     ..      ||.|.|.  .|.  | ||||| ||.||.|.|.||
a......agGfvelnrvngnLalsralgDfefkknvk.....................kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkev

VHYVQEHVCKKVE
|..|.|.. .. .
vdlvrerlvsgak

subfamily_PPM1G_pd Subfamily PPM1G 239-430 1.4e-25 83.2 In-house 271-435 (473) alignment
Range on Protein: 239-430
Range on HMM: 271-435/473.0
NEAVKESKS-KLPEGSSCHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAGNPEEVQRILNQhppeeSTTVIRFERLL
.| .....  .  .||  .     ..|. | || ... .|. |||||.|.||  .|.     |..|| ||   ...| .|| .        .|    |. 
eedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGk.....AldlslDHkPeDevEleRiekA.....GGkvdedgRvn

GRLAPLRAFGDARFKWDKKTQNKVYSksslnpmsevehfytppyLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVED
| |   ||.||  .| ... ..|                     ..| |..   .|.  |.|||||.||.|.... .||| .|.... |. |.
GGLnlsRAlGDhaYkkneeLplkeqm..................isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees

PPM_PTC7_SpoIIE 225-441 4.3e-20 65.5 In-house 72-223 (230) alignment
Range on Protein: 225-441
Range on HMM: 72-223/230.0
SIREAYIRLDQDIRNEavkesksklpegsschafdAANAGACALVAYIQGTE--LFLANAGDCRAVLGVQgEDGcwsamqlssdhtagnpeEVQRILNQH
 .|... .|..|...|                    .. ||.|.||.|...   | .|||||....|  . ..|                 |. ||    
ilrrlnlalaadlede...................psssgaTavvalidpstgklyvanaGdsppllvrd.dgg.................ererivagg

PPE----ESttvirfeRLLGRLAPLRAFGDARFKWdkktqnkvysksslnpmsevehfyTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVH
.|.    .        |  | ||  .|.||  ..                         |  . .|||. .   | . |.||.||.|||||.||..|.|.
lpslGilpg.......rvfgvlavslapGdlllly........................tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvd

YVQEHVCKKvedTSKGVLPQDIT
 |.... |.    ..| |  |||
lvrdelekp...aaeglleDDit

subfamily_TAB1_pd Subfamily TAB1 112-412 1.1e-17 56.8 In-house 9-261 (333) alignment
Range on Protein: 112-412
Range on HMM: 9-261/333.0
ASNQPMEDRKFVVrlLHQDGGYLFGVMDGHGGNACAHNVCKRLPDyialSLLHrhvllahPDLMPKLTDYLTITKnedhcYNYandpACRNSLNKYFYEL
  ....||. |..    ... .|..| ||. ||  |. | .||.      ||        ..|...|... .        ..     |  .  .|.. ..
kedhevedkvflf..ktendpilyavFdGydGnkaakfveqrLva....elll.......eqltdelaeaevkev.....lkr....afeeverkflesi

QDMVEAHVEMHVRsireayirLDQDIRN-EAVKESKSKLPEGSSCHafDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgCWSAMQLSSDHTAG
.|... . ... .        | ... . |. .....|.   .. .  .  . |. |.|| |   .|. ||.|| ||.|  . |       |||.|||  
ddalaekddlqsq........lPegvssyeleeqypekierlqele..eeisgGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttd

NPEEVQRILNQHPpeeSTTVIRFERLLGRLAPLRAFGDARFKWDKKtQNKVYSKSSLNPMsevehfytppylTAEPEVMS-YQLQRTDKFLVLATDGLWD
|..|..|. .       .  |.  ..||   . |. || . |   | .....|... .|.             |||..   |... . .||||  ||.  
NedEllRlkdLGl...dieqikrnkrlgskentRsiGdykvkkgyk.dvdilssakgePv............iaePdiqgaypiddityflvlmSdGvyk

MLS
 | 
tLe

subfamily_PPM1D_pd Subfamily PPM1D 133-319 2.5e-13 42.8 In-house 36-165 (309) alignment
Range on Protein: 133-319
Range on HMM: 36-165/309.0
YLFGVMDGHGGNACAHNVCKRLPDYIALSllhRHVLLAHPDLMpkltdyltitknedhcynyandpacrnslnkyfyelqdmveahvemhVRSIREAYIR
  ..|.|||||.  |. . ..|  .|      ...|  .|. .                                               .. ||||.. 
afvavfDGHGGkeAakfarehlwsvikkq...kkflssepedv...............................................leAireafla

LDQDIRneavkESKSKLPEGSSCHafdAANAGACALVAYIQGTELFLANAGDCRAVLGVQGE-DGCWSAMQLSSDHTAGNPEEVQRIL
. . ..     ..... |.  | .    . ||. | |  |....|..|. || ..||||. . .  . | .| .||   .|||..|| 
theamk.....kkleeWpktksgl...lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerie

subfamily_PPM1E_pd Subfamily PPM1E 380-432 9.2e-13 41.0 In-house 184-236 (265) alignment
Range on Protein: 380-432
Range on HMM: 184-236/265.0
PYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTS
||...|..|....|. ....|.||.|||||.. .||||. |.|.. ...||.|
pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedls

subfamily_PPM1L_pd Subfamily PPM1L 115-352 9.7e-13 41.0 In-house 17-188 (269) alignment
Range on Protein: 115-352
Range on HMM: 17-188/269.0
QPMEDRKFVVRLLHQD-GGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRhvllahpdlmpkltdyltitknedhcY-------Nyandpacrnslnk
. ||||  .   .... |  .|.|.|||||.  |. . ..|.. |   |..                                                 
prmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel..........................dadkentep.............

yfyelqdmveahvemhvrsireayIRLDQDIRNEAVKeSKSKLPEGSScHAfdAANAGACALVAYIQGTELFLANAGDCRAVLgvqgEDGCWSAMQLSSD
                        |  .. . .| .     || |    .|     ||. ||.| .|...| .|| || | ||     |    |. || |
........................infsklltdeils.vdekllekak.ra..ediaGttalialvqesdlivanvGdsrGvl....ydkrGkaiplsfd

HTAGNPEEVQRILNQHPPEESTTVirfERLLGRLAPLRAFGDARFK
|   ...| .|| .         |    |. | ||  ||.||  .|
hkpqqvkerkrikkaGGfiafrGv...wrvaGvlatsralGdyplk

subfamily_PPM1H_pd Subfamily PPM1H 376-428 9.6e-12 37.3 In-house 299-355 (404) alignment
Range on Protein: 376-428
Range on HMM: 299-355/404.0
FYTPPYLTAEPEVMSYQLQR----TDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKV
 .  |.|...|||. ..|.     .|. |.||||||||.|||||| . |.| . |  
lsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve

subfamily_PPM1K_pd Subfamily PPM1K 213-352 3.2e-11 35.9 In-house 47-182 (263) alignment
Range on Protein: 213-352
Range on HMM: 47-182/263.0
DMVEAHVEMHVRSIREAYIRLdQDIRNEAVKESKSKLPEGSSCHAF--DAANAGACALVAYI-QGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTA
| |  ..| ... . |    | . . ..| .| . ||      .    .  ..|. | |. . .|||| ||. || ||.|  .|.     |..|..||. 
dfvhdklekilkrllekekdl.eivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk.....akkltrdhdP

GNPEEVQRILNQHPPEESTTViRFERLLGRLAPLRAFGDARFK
   || .||..     |....    .. ||||  |..||  .|
eleeekerikaagGsvewnsl.gkplvngrlamtrslGdldlk

subfamily_PPM1L_pd Subfamily PPM1L 383-424 4.4e-11 35.6 In-house 194-236 (269) alignment
Range on Protein: 383-424
Range on HMM: 194-236/269.0
TAEPEVMSYQLQR-TDKFLVLATDGLWDMLSNEEVVHYVQEHV
 |.|......|.    .||.||.||||| .|||| |....|..
iadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl

subfamily_PPM1H_pd Subfamily PPM1H 131-311 6.8e-11 34.5 In-house 61-205 (404) alignment
Range on Protein: 131-311
Range on HMM: 61-205/404.0
GGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPDLmpkltdyltitknEDHCYNYANDPACRNSLNKYFyeLQDMVEaHVEMHVRSIREAY
  ..||. |||.|.. |    | |   .   | .   ||.. .              |..    ....   .| .. .   .  .. . |. . .. .|.
playfglfDGhaGsgaalvaskllhkhlkekledvlellleksa.............eeeenteesskespssvseiy..eekeis.keeLviGalesaf

IRLDQDIRNEAVKeskSKlpegsschafdaANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDgcwsaMQLSSDHTAGN
...|. |..|  .    .             . | .|||| .    |..|||||.||.|  ..|      ..||.|.|   
lemDeqiarerea...yr............ikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPet

subfamily_ILKAP_pd Subfamily ILKAP 382-431 2.4e-10 33.1 In-house 201-250 (293) alignment
Range on Protein: 382-431
Range on HMM: 201-250/293.0
LTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDT
... |.|.  .|.  |.|.||| ||||. .|..|||..... . .. .|.
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 376-422 3.4e-10 32.6 In-house 175-222 (255) alignment
Range on Protein: 376-422
Range on HMM: 175-222/255.0
FYTPPYLTAEPEVM-SYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
 .  |.....|..  |.. ...||||.|| ||.||..|.|| |. | .
sflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag

PPM_PTC7_motif 401-427 3.5e-10 33.2 In-house 1-27 (51) alignment
Range on Protein: 401-427
Range on HMM: 1-27/51.0
VLATDGLWDMLSNEEVVHYVQEHVCKK
.||.|||||.||..|.|. |.....||
iLAsDGLWDvlsdqeavdlvrdqlskk

subfamily_PP2D1_pd Subfamily PP2D1 384-438 9e-10 30.8 In-house 266-320 (492) alignment
Range on Protein: 384-438
Range on HMM: 266-320/492.0
AEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTSKGVLPQ
 ||.. | .|. ...|||||. |||..||.|||.  |.. .    . . ....|.
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd

subfamily_PPM1D_pd Subfamily PPM1D 384-463 1.7e-09 30.2 In-house 224-287 (309) alignment
Range on Protein: 384-463
Range on HMM: 224-287/309.0
AEPEVMSYQLQRT-DKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTSKGvlpqditfneqelpcdlNNAASCLVREAL
 ||.|. ..|.   .||..||.||||..|. |..|. |... .||.   ...                 .. |..||.|||
PePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.................rsvakalvkeal

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 261-349 7.2e-09 28.3 In-house 93-175 (255) alignment
Range on Protein: 261-349
Range on HMM: 93-175/255.0
ANAGACALVAYIQGTELFLANAGDCRAVLGVQgeDGcwSAMQLSSDHTAGNPEEVQRILNQHPPEESTtvIRFERLLGRLAPLRAFGDA
   |. | ...| .   ..|| || |.||. .  ||   | .|| ||   ...| .|| .      ||      |. | ||  ||.||.
kfiGttaasvliiedkvyianvGdsrvvlcqk..dg..takrlsldhkPseeseekriselGGtvvst..vvtsrvnGtlavsralGds

subfamily_ILKAP_pd Subfamily ILKAP 264-352 1.1e-08 27.6 In-house 114-197 (293) alignment
Range on Protein: 264-352
Range on HMM: 114-197/293.0
GACALVAYIQGTELFLANAGDCRAVLGVQGEDGC-WSAMQLSSDHTAGNPEEVQRIlnqhppEESTTVIRFERLLGRLAPLRAFGDARFK
|. | |  .    |. || || .|||  . |.|   ....|. |||. . || .||      . . .|.|  |.|| |   |. || |||
GstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkri......qkaGgvvrdgrvlGvlevsrsiGdgrfk

PP2C_SIG_SM00331 211-495 1.5e-08 27.5 In-house 52-216 (217) alignment
Range on Protein: 211-495
Range on HMM: 52-216/217.0
LQDMVEAHVEMHvRSIREAYIRLDQDIRNEavkesksklpegsscHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVqgEDGCWSAMQLssdhtag
|..... ... .  .. .|  ||.. |..|               . ..   | .....  ... .| .|||||.| .|    ...     .        
lrtalrellseg.eelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrpyllr..dgklveilkd.......

npeevqrilnqhppeesttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmseV-----------EhfytppyltaePEVMSYQLQRtDKF
                                                              |           .           ... . .|.  . .
..............................................................vegaplGlepevs...........vdirelelek.gdl

LVLATDGLWDMLSNE-----EVVHYVQEHVCKKVEDTSKGVLPQDITFNEQELPcdlnnaasclvrealggddhvavsttlsipypdvrmyRDDISVIVV
|.|.||||... | .     .. . ....|.  ... ..  . . ... ...                                       .|||.|.||
lllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng.....................................eDdiTvvvv

F
.
k

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 214-320 8.2e-08 25.1 In-house 40-143 (292) alignment
Range on Protein: 214-320
Range on HMM: 40-143/292.0
MVEAHVEMHVRSIREAYIRLDQDIRNEAVkESKSKLPEGSSCHAFDAANAGACALVAyiQGTELFLANAGDCRAVLGVQGEDGCWSAMQLSSDHTAGNPE
. | ..|... .       | . . .  . .  .|| .    .   |. |  || |    . .|.||| || ||.||          . || ||   .|.
laedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvr..ddralilanvGdsrallgrclggsdyeliPlsrdhkPedPd

EVQRILN
| .|||.
erarilr

subfamily_PHLPP_pd Subfamily PHLPP 372-422 2.3e-07 23.0 In-house 164-214 (246) alignment
Range on Protein: 372-422
Range on HMM: 164-214/246.0
EVEHFYTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
 . .... |..  .|.| . .|.  | .|..  . ||..|| .|.|. |..
llGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrk

PP2C_2 Protein phosphatase 2C 228-431 3.2e-07 22.8 Pfam-A 82-201 (212) alignment
Range on Protein: 228-431
Range on HMM: 82-201/212.0
EayirldqdirneavkesksKLPEGSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVlgVQGEDGCWSAmqLSSDHTAGNPEEVQRILNQHPPEES
.                   .  | .. .. .. . ..  |.| |...|..... ||...|  |...|| . .  |..... .   |....  . . || 
k...................lkqeaeaqqe.elkdyatTlllavitpgeivffqiGDgaiv..vrdrdgevql..lgepdsgeyanettfltsedaeeel

ttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmsevehfytppyltaepEVMSYQlQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
                                                           .. . .  .  . |.| |||..|.|..|| .. . ......
...........................................................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet

VEDT
.|..
leee

PP2C_2 Protein phosphatase 2C 228-431 3.2e-07 22.8 In-house 82-201 (212) alignment
Range on Protein: 228-431
Range on HMM: 82-201/212.0
EayirldqdirneavkesksKLPEGSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVlgVQGEDGCWSAmqLSSDHTAGNPEEVQRILNQHPPEES
.                   .  | .. .. .. . ..  |.| |...|..... ||...|  |...|| . .  |..... .   |....  . . || 
k...................lkqeaeaqqe.elkdyatTlllavitpgeivffqiGDgaiv..vrdrdgevql..lgepdsgeyanettfltsedaeeel

ttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmsevehfytppyltaepEVMSYQlQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
                                                           .. . .  .  . |.| |||..|.|..|| .. . ......
...........................................................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet

VEDT
.|..
leee

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 387-422 4.3e-07 22.7 In-house 237-272 (292) alignment
Range on Protein: 387-422
Range on HMM: 237-272/292.0
EVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
  .. .|.. |.|||||.||. |.|.|.||| ....
rklekeldsddaflvlasdGvldvllnaevvlllak

Subfamily Dicty-PPM1L-like 395-427 2.6e-06 19.5 In-house 234-266 (305) alignment
Range on Protein: 395-427
Range on HMM: 234-266/305.0
RTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
  |.||||||||||..||...||  |.| . .|
anDqflvlatdGlwevlsyqdvveevkellrdk

subfamily_PPM1K_pd Subfamily PPM1K 383-443 2.7e-06 19.7 In-house 187-246 (263) alignment
Range on Protein: 383-443
Range on HMM: 187-246/263.0
TAEPEVMSYQL-QRTDKFLVLATDGLWDMLSNEEVVHYVQehVCKKVEDTSKGVLPQDITFN
 |.||  | ..   .| |||| |||. ......|. ..|.  .|.. |.... .  | . . 
iatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr..lchdpeeaahalteqalqyg

subfamily_PPTC7_pd Subfamily PPTC7 387-432 4.2e-06 19.3 In-house 158-202 (252) alignment
Range on Protein: 387-432
Range on HMM: 158-202/252.0
EVMSYQLQRTDkFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTS
...|..... |  .|||||||.| |...|... ..|  ... ..  
dsksfavkkgD.iivlatDGlfDNlledeileilkelkeseksslq

subfamily_PP2D1_pd Subfamily PP2D1 271-320 9.6e-06 17.5 In-house 184-228 (492) alignment
Range on Protein: 271-320
Range on HMM: 184-228/492.0
YIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGNPEEVQRILN
 .. . |..||||. .|||  .|     .|..|  .|| .|..| .|. .
leelgvlyianaGnvqAvLcreG.....kaiiLtreHtprnkkERtRvek