Gene PP2D1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PP2D1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP140_AA protein Get Run
NvecP140_AA_306-728 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PP2D1_pd Subfamily PP2D1 419-729 4.2e-131 431.0 In-house 187-491 (492) alignment 
Range on Protein: 419-729
Range on HMM: 187-491/492.0
PSTCYLSHVGDVGAILIREdGVTKILTRKHDLYNKKERDRVRKSSGVIVKTEKCALVNGALGVTRGLGNIGDGELNQSVIIAPKFRCTCLTNRDQVLVFA
....|....|.|.|.|.|| |...||||.|...|||||.||.|...|.||.||..||||.|..||||||.||..|..|||..||.....|....|.||.|
lgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlA

SSGLWKVFSAEEVANLVLGFFRQIKESVRKGIIWGSRVPCVCANGHMEFEGKKFAARYANCGayYRKFLRPEPKREIGRPATSHMFNFMSYNELDNITEE
|.|||.|.|.|||..|| ......|..||......|.|..|......|.|.||..|||.|.|  ..||...|..........|......|||||....|.
snGlWevlseeevlsLvkqtlaiyksrvraenvpdsdvttvgedylgEleakklsaryentg..fdkfvtseidldaaegdesnlqklfsynelsevked

TPTTRAGLSVPVWFKRVGRRLSDTcivyrDPDAIQDEQLNTSHERFTNRRHSLPHRAGMTKLYGPLGFRPD--LSPQDKIELVAKSLAERIVKSALLAGS
....|.|||.....|..... .||     |..|........|.|..|||.......|...|.... ....|  .....|.||.|..|.||.|.|||||||
addereglseanskkeityneedt.....dksaeeskeaksseekstnrsirveevaenvkaekeeetksdgivdkkekyelaAealserlvqsALlAGs

IDNLTVCSVLLPG
.||.||...||.|
rDnitvmvilLkG
0034914 PP2C-like 307-728 6.6e-46 149.5 In-house 22-291 (295) alignment 
Range on Protein: 307-728
Range on HMM: 22-291/295.0
AVGVCEEVNArWKNMEDAHHLQDDFLP-QTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASH---TDLTKTDFKTAFRRSYARFQELLRTRTEDeeR
 |||.  ..   |..|||.    ..|. ... ...|..||. | ..|. ... |..|..|.| ..   ..|. .|...|.|... . .| |.. ...  |
rvgvasdqGr.rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall..r

SRNRWSGCSALTCVVTPSTCYLSHVGDVGAILIReDGVTKILTRKHDLYNKKERDRVRKSSGVIVKtekcALVNGALGVTRGLGNIGDG------ELNQS
.. ..||..|..........|. .|||  |.|.| .|. . ||. |...|  || |.... |...       ||| | ||| ||            |.. 
pelagsGtTavvalirgnklyvanvGDSravllr.ngelvqltvdhkpvnelererilsaggavsh....grvngvlavtRalGdfdlklllsllllepl

VIIAPKFRCTCLT-NRDQVLVFASSGLWKVFSAEEVANLVLGFFRQIKEsvrkgiiwgsrvpcvcanghmefegkkfaaryancgayyrkflrpepkrei
|.  | .... || . |..|..|| |||.|.| ||....|  .... ..                                                   
vsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld...................................................

grpatshmfnfmsyneldniteetpttraglsvpvwfkrvgrrlsdtcivyrdpdaiqdeqlntsherftnrrhslphragmtklygplgfrpdlspqdk
                                                                                                    
....................................................................................................

ielvAKSLAERIVKSALLAGSIDNLTVCSVLLP
    .. .||..|. || .|| ||.||. | |.
....leeaaeeLvdlAlargsrDNiTvvvvrln
PP2Cc_SM00332 313-536 2.6e-39 128.3 In-house 16-237 (274) alignment 
Range on Protein: 313-536
Range on HMM: 16-237/274.0
EVNARWKNMEDAHHLQDDFLPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLTKTDFKTAFRRSYARFQELLRTRTEDEERSRnRWSGCSA
.   . |.|||||. . |. ...   |.|..||  |  .|. ....|.. ..|.| ...|  . | . | .... ...| ...  . .|. .   ||..|
smqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.alsGsta

LTCVVTPSTCYLSHVGDVGAILIREDGvTKILTRKHDLYNKKERDRVRKSSGVIVKTekcaLVNGALGVTRglgNIGDGELN-------QSVIIAPKFRC
......  . |...|||  |.|.|..   . |...|   ...||.|..|. ||. |      ||| | |.|   ..||..|        . ..  |.  .
vvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg....rvngglavsr...afGdhflkknkklkepyitaepdvkv

TCLTNRDQVLVFASSGLWKVFSAEEVANLVL
. ||. |..|..|| ||| |.| .|| ..| 
vtltsedeflilaSDGlwdvlsnqevvdivr
subfamily_PPM1A_pd Subfamily PPM1A 309-728 6.8e-39 126.9 In-house 15-281 (282) alignment 
Range on Protein: 309-728
Range on HMM: 15-281/282.0
GVCEEVNaRWKNMEDAHHLQDDFLPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSE--QL--ASHTDLTKTDFKTAFRRSYARFQELLRTRTEDEERSr
|| .  . . ..|||||. . ..  ..   |  ..||  | . |. ....|.. . |  .|  |. .. .| . | |.|... ...| .|. ..| . . 
gvssmqg.wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlkta.

nRWSGCSALTCVVTPSTCYLSHVGDVGAILIREdGVTKILTRKHDLYNKKERDRVRKSSGVIVktekCALVNGALGVTRGLGNIGDGE------LNQSVI
   ||. |.|..|.... .. ..||  |.|.|. | ...||. |  ...||..|...  | .|       ||||| |.| ||     |       .| |.
.dksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkaeeqlvs

IAPKFRCTCLTNRDQVLVFASSGLWKVFSAEEVANLVLGFFRQIKESVRKgiiwgsrvpcvcanghmefegkkfaaryancgayyrkflrpepkreigrp
  |. ...  .. |. || |. |.| | | |||..||   ... .|  .                                                   
aepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev..................................................

atshmfnfmsyneldniteetpttraglsvpvwfkrvgrrlsdtcivyrdpdaiqdeqlntsherftnrrhslphragmtklygplgfrpdlspqdkiel
                                                                                                    
....................................................................................................

vakslAERIVKSALLAGSIDNLTVCSVLLP
     |...|. || .|| |||.|. ||..
.....akalvdkalekgsrDNlsvlvvlfa
PP2C Protein phosphatase 2C 313-535 1.9e-37 122.3 Pfam-A 7-225 (255) alignment 
Range on Protein: 313-535
Range on HMM: 7-225/255.0
EVNARWKNMEDAHHLQDDFL---PQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLtktDFKTAFRRSYAR-FQELLRTrtEDEERsRNRWS
|.. . |.|||||.. ...    .. .  |....||  |  .|......|.... ||   ...    . . |.|.|... ..| |..  ... .     |
elqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...kvekalrksfladtdeelks..skant.epsks

GCSALTCVVTPSTCYLSHVGDVGAILIREDGVTKILTRKHDLYNKKERDRVRKSSGVIVKtekCALVNGALGVTRGLgniGDGELNQ----SVIIAPKFR
|..|......... |. .|||  |.|.| |.  | ||..|. ....||.|.... | . .   .  ||| | |.| |   || || .     |. .|. .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRal...GdfelkpkeeqlvsaePdvt

CTCLTNRDQVLVFASSGLWKVFSAEEVANLV
 . ||..|. |. || ||| |.| .|.. ||
svklteedefliLasdGlwdvlsdqeavdlv
PP2C Protein phosphatase 2C 313-535 1.9e-37 122.3 In-house 7-225 (255) alignment 
Range on Protein: 313-535
Range on HMM: 7-225/255.0
EVNARWKNMEDAHHLQDDFL---PQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLtktDFKTAFRRSYAR-FQELLRTrtEDEERsRNRWS
|.. . |.|||||.. ...    .. .  |....||  |  .|......|.... ||   ...    . . |.|.|... ..| |..  ... .     |
elqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...kvekalrksfladtdeelks..skant.epsks

GCSALTCVVTPSTCYLSHVGDVGAILIREDGVTKILTRKHDLYNKKERDRVRKSSGVIVKtekCALVNGALGVTRGLgniGDGELNQ----SVIIAPKFR
|..|......... |. .|||  |.|.| |.  | ||..|. ....||.|.... | . .   .  ||| | |.| |   || || .     |. .|. .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRal...GdfelkpkeeqlvsaePdvt

CTCLTNRDQVLVFASSGLWKVFSAEEVANLV
 . ||..|. |. || ||| |.| .|.. ||
svklteedefliLasdGlwdvlsdqeavdlv
PPM_PTC7 313-538 2.1e-35 115.4 In-house 7-233 (259) alignment 
Range on Protein: 313-538
Range on HMM: 7-233/259.0
EVNARWKNMEDAHHLQDDFL---PQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLtktDFKTAFRRSYARFQELLRTRTeDEERSRNRWSG
. ... |.|||||.. ...    .. .  | ...||  | ..|......|.. . |.    ..    . . |.| |... .   .... .|...    ||
afqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele...klekalrksflaldtdeelks.seantepstsG

CSALTCVVTPSTCYLSHVGDVGAILIREDGVTKILTRKHDLYNKKERDRVRKSSGVIVKTeKCALVNGALGVTRGLgniGDGELNQ------SVIIAPKF
..|.....|.|. |  .||| .|.|.| ... | ||..|. .|..||.|.... | . .  ..  ||| | |.| .   || || .       |. .|  
stAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRaf...GdfelkpketeeqlvsaePdi

RCTCLTNRDQVLVFASSGLWKVFSAEEVANLVLGF
  | ....|. |. || ||| |.| .|.. ||  .
sstkideedefliLasdGlwdvvsdqeavdlvrse
0049733 PP2C-like 309-727 6.4e-32 103.9 In-house 6-233 (235) alignment 
Range on Protein: 309-727
Range on HMM: 6-233/235.0
GVCEEVNARWKNMEDAHHLqddflpqtPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLAShtdLTKTDFKTAFRRSYARFQELLRTRTEDEErsRNRWS
|..  .. . |..|||. .           .....||  |.  .. ....|.... |.|..   |. .| ..|.|... . .| |. ......    ...
gaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle...lllldleealrkaflaaneallelalasp..elagm

GCSALTCVVTPSTCYLSHVGDVGAILIReDGVTKILTRKHDLYNKKERDRVRKSSGVIvktekcaLVNGALGVTRGLGnigDGELNqsviiaPKFRCTCL
|..|..........|. .|||  |.|.| ||    ||. | ..|  || |...  |..        |.| | .|| ||   | .|.      | .... |
gtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav.......rvpgrlaltralG...dlllk......pdvtvlel

TNRDqVLVFASSGLWKVFSAEEVANLVLGffRQIkesvrkgiiwgsrvpcvcanghmefegkkfaaryancgayyrkflrpepkreigrpatshmfnfms
.. | .|..|| |||.|.| ||...|. .    .                                                                  
epgd.flllasDGlwdvlsdeeivdllrs..ldl..................................................................

yneldniteetpttraglsvpvwfkrvgrrlsdtcivyrdpdaiqdeqlntsherftnrrhslphragmtklygplgfrpdlspqdkielvaKSLAERIV
                                                                                            . .|||.|
............................................................................................eeaaerlv

KSALLAGSIDNLTVCSVLL
. || .|. ||.||  | |
elalarggrDNiTvvvvrl
subfamily_PP2D1_pd Subfamily PP2D1 306-369 3.6e-31 101.4 In-house 1-65 (492) alignment 
Range on Protein: 306-369
Range on HMM: 1-65/492.0
KAVGVCEEVNARWK-NMEDAHHLQDDFLPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLAS
||||.||..|.||| .|||...|||.|.....|||.||||||.|.|.|...|..||....|.|..
kavGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelek
subfamily_PPM1E_pd Subfamily PPM1E 316-543 3.1e-30 98.2 In-house 13-232 (265) alignment 
Range on Protein: 316-543
Range on HMM: 13-232/265.0
ARWKNMEDAHHLQDDF------LPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLTktdfkTAFRRSYARFQELLRTRTEDEERSrnrwSG
 . . ||| |   .|.        ...  | ...||. |  .|.  |..||.|. .|   ..| .     .|..... .  | . ...| |.      ||
nkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.....ealkeafkltDerflqkaereklk....sG

CSALTCVVTPSTCYLSHVGDVGAILIREdGVTKILTRKHDLYNKKERDRVRKSSGVIVKTeKCALVNGALGVTRGlgnIGDGELNQSVIIAPKFRCTCLT
. | ..... .. |.. .||  |.|.|. | .  |.. |   ...|..|. .  |..|..  .  ||| | |.|    ||| .|.. |.  . .  . |.
stavvvliekdqlyvaWlGDsqallvrk.geavqlmkpHkPeredEkkRieeagGlvvvi.gawRvnGvLsvsRa...iGDvklkpyvsgeadvaeveld

NRDQVLVFASSGLWKVFSAEEVANLVLGFFRQIK
. ...|. |. ||| |.  ||| .||  |... .
gseeylilacDGlwDvvneeevvklveefladga
subfamily_ILKAP_pd Subfamily ILKAP 315-541 8.9e-30 96.8 In-house 13-245 (293) alignment 
Range on Protein: 315-541
Range on HMM: 13-245/293.0
NARWKNMEDAHHLQDDFLPQ--------TPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLAShTDLTK--TDFKTAFRRSYARFQELLRTRTedeERSR
.   ..|.||| ...|. .|        .  .. ...||..|  ... .|..||. . |.|.. .|...  .. | ..  |...  | . .     ....
kGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLkla...skak

NRW-SGCSALTCVVTPSTCYLSHVGDVGAILIREDGVTK-----ILTRKHDLYNKKERDRVRKSSGVIvKTEKcalVNGALGVTRglgNIGDGELNQS-V
  |  |. | ...|   . | . .||  |.|.| .  ..      ||. |.  ...|| |..|. ||. .  .   |.| |.|.|    ||||.  .. |
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdgr...vlGvlevsr...siGdgrfkrlGv

IIAPKFRCTCLTNRDQVLVFASSGLWKVFSAEEVANLVLGFFRQ
|  |. .   ||. |. .| |  ||||||||.||.. .|  . .
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvled
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 313-537 3.4e-27 88.3 In-house 12-222 (255) alignment 
Range on Protein: 313-537
Range on HMM: 12-222/255.0
EVNARWKNMEDAHHLQDDFLPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLashtDLTKTDFKTAFRRSYARFQELLrtrtedeeRSRNRWSGCSA
..  |   |||   .   |  .. . .. ..||..| ..|. .. .|.... | |    || ... . .....|   . ..          | .. |..|
dmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaell....dlnnanPvkslkkaykeistqi........serpkfiGtta

LTCVVTPSTCYLSHVGDVGAILIREDGVTKILTRKHDLYNKKERDRVRKSSGVIVKTEKCALVNGALGVTRGLgniGDGELNQSVIIAPKFR-CTCLTNR
 . ...    |.. |||  ..| . ||..| |.  |   ...|. |...  | .|.| . . ||| | |.| |   ||  |.  |.  |..      ...
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsral...GdsflePfvvpdPdlsqsleiskk

DQVLVFASSGLWKVFSAEEVANLVLG
|. |. |  |.| . | ||  ..|.|
dkflilacdGiwdlisdeeaveivag
subfamily_PPM1G2_pd Subfamily PPM1G2 319-535 9.8e-25 80.1 In-house 31-243 (287) alignment 
Range on Protein: 319-535
Range on HMM: 31-243/287.0
KNMEDAHHLQDDFLP---QTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLTKTDFKTAFRRSYarfQELLRTrtedeERSRNRWSGCSALTC
 |||||| |....|    ..   .....||. | . |. ....|.. . .. . . .  .. .| || .     .|||.      |. ..  .|. |.. 
lnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD...eellkd.....eklkdesaGstavvv

VVTPSTCYLSHVGDVGAILIREDGvTKILTRKHDLYNKKERDRVRKSSGVIvKTEKcalVNGALGVTRGLGNIGD------GELNQSVIIAPKFRCTCLT
... .  | . .||  |.|  .   .| |.. |   ...|. |. .. |.. . ..   |||.| . | ||.         .  .| | . |   .. |.
likeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfv.elnr...vngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkld

NRDQVLVFASSGLWKVFSAEEVANLV
..|  || |  |.| |.. .|| .||
eddeflvLaCDGiWDvltnkevvdlv
subfamily_PPM1K_pd Subfamily PPM1K 338-535 3.8e-21 68.4 In-house 32-225 (263) alignment 
Range on Protein: 338-535
Range on HMM: 32-225/263.0
CFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLTKTdFKTAFRRSYARFQELLRTRTEDEersRNRWSGCSALTCVVTP-STCYLSHVGDVGAILIR
 .....||..| ..|  . ..|.. . . |    || .  .| ||     ...  |.    ..       || .|  ...       |. .||  ||| |
lyvavfdGhaGsaaadfvhdklekilkrllekekdleiv.lknafeeldkklkrylefsvaea...ellssGttatvsllrdGtelvlaslGdsrailcr

EdGVTKILTRKHDLYNKKERDRVRKSSGVIVKTE-KCALVNGALGVTRGLGNIgdgELNQS-VIIAPKFRCTCL-TNRDQVLVFASSGLWKVFSAEEVAN
. | .| ||| ||   ..|..|.....| .  .     |||| | .|| ||..   .| .. ||  |. .   .  ..|  ||. . |.  | . .|...
n.GkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdl...dlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcd

LV
||
lv
subfamily_PPM1L_pd Subfamily PPM1L 314-536 4.5e-21 68.3 In-house 12-233 (269) alignment 
Range on Protein: 314-536
Range on HMM: 12-233/269.0
VNARWKNMEDAHHLQDDFLPQTPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHTDLTKTDFKTAFRRSYarFQELLRTRTE--DEERSRNRWSGCS
|  | ..|||  ....|   .|   |....||. | ..|  . . | . . ..|       .     .| .     .|.|   ..  .. .. .  .|..
vlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfskll..tdeilsvdekllekakraediaGtt

ALTCVVTPSTCYLSHVGDVGAILIREDGVTKILTRKHDLYNKKERDRVRKSSGVIVkTEKCALVNGALGVTRGLGNIGDGELNqSVIIAPKFRCTCLTN-
||  .|. |   .. |||   .|. ..| .  |.  |  .. ||| |..|. | |   . .  |.| | ..| ||.    . |  ||  |   .  | . 
alialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfia.frGvwrvaGvlatsralGdyplkdkn.lviadpdiltfdlddh

RDQVLVFASSGLWKVFSAEEVANLVL
. . |..|| |||  || ||  . ..
kpeflilasdGlwdtfsneeavrfik
subfamily_PP2D1_pd Subfamily PP2D1 370-418 4.9e-17 54.8 In-house 103-152 (492) alignment 
Range on Protein: 370-418
Range on HMM: 103-152/492.0
HTDLTK---TDFKTAFRRSYARFQELLRTRTEDEerSRNRWSGCSALTCVVT
.....|   ...|.|||.||.|...||....|.|  ||.|||||||||....
keesvkpefekvkkAfrksylrldrlLsygieee..srvrWsGCsAltllle
PPM_PTC7_SpoIIE 313-536 1.2e-15 50.9 In-house 7-206 (230) alignment 
Range on Protein: 313-536
Range on HMM: 7-206/230.0
EVNARWKNMEDAHHLQDDFL---PQTPSCFIGIYDGycGGTTARKCASQLHQLVSEQLASHTDltktDFKTAFRRSYARFQELLRTRtedeersrNRWSG
. ... |.|||||.. ...    ..    ..|..||   |  | .....|.... |.    ..    . . ..||......  |...        .  ||
aaqgarksmedahispansekssggrlalvvgdvdG..hGgraalamgllrtalrelafagle....kpeeilrrlnlalaadlede........psssg

CSALTCVVTPST--CYLSHVGDVGAILIREDGVtkiltrkhdlynkkERDRVrKSSGVI-V---KTekcaLVNGALGVTRGLGnigDGELNQS--VIIAP
..|. ....|||  .|....||  ..|.| ||               || |. .. | . .    .     |.| | |..  |   |  |  .  |. | 
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpg....rvfgvlavslapG...dllllytDGvveae

KFRCTCLTNR-DQVLVFASSGLWKVFSAEEVANLVL
    . .. . |. |. ||.||| | |..|.. ||.
pdtsdgelfgkdeflilasdglwdvlspqelvdlvr
subfamily_PPM1G_pd Subfamily PPM1G 399-550 2e-13 43.1 In-house 287-440 (473) alignment 
Range on Protein: 399-550
Range on HMM: 287-440/473.0
DEERSRNRWSGCSALTCVVTPSTCYLSHVGDVGAILIREdGVTKILTRKHDLYNKKERDRVRKSSGVIVKTEKcalVNGALGVTRGLGNIG---DGEL--
.|. .  . ||. |  ...   . .   .||  ..| |. |.   |   |   ...|..|..|  | . .  .   ||| | . | ||.     . ||  
eekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvdedgR...vnGGLnlsRAlGDhaYkkneeLpl

-NQSVIIAPKFRCTCLTNRDQVLVFASSGLWKVFSAEEVANLVLGFFRQIKESVRKGI
 .| .   |  . . ||. |. || |. |.| | ...|| . |   ... .||| . |
keqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlsei
subfamily_KAPP-like_pd Subfamily KAPP-like 339-540 3.1e-13 42.4 In-house 36-233 (266) alignment 
Range on Protein: 339-540
Range on HMM: 36-233/266.0
FIGIYDGYCGGTTARKCASQLHQLVSEQLAShtdlTKTDfkTAFRRSYARFQELLRTRT-EDEERSRNRWSGCSALTCVVTPS--TCYLS--HVGDVGAI
.....||..|  .|      . . . ..| |    || |        | . . |. .    |.. .   . |..|  ..|  .    ||    |||  |.
lfavfdGhaGkGaadaakklfpkelekllks....tkqd..dGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaf

LIREDGvTKILTRKHDLYNKKERDRVrKSSGVIVkTEKCALVNGaLGVTRGLGNIGDGELNQSVIIAPKFRC-TCLTNRDQVLVFASSGLWKVFSAEEVA
| | .  .  |.  |   ...|. |. |  |. . ... . .|| | |.| ||.    |||  .|  |       ||  |. |. || ||| | | ..  
lsrGne.slelskdhkakdpeekqri.kddGitl.sdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdai

NLVLGFFR
. |  .. 
ekvkslyd
subfamily_PPM1D_pd Subfamily PPM1D 319-535 1.1e-12 40.7 In-house 14-261 (309) alignment 
Range on Protein: 319-535
Range on HMM: 14-261/309.0
KNMEDAHHLQDDFLPQ---TPSCFIGIYDGYCGGTTARKCASQLHQLVSEQLAShTDLTKTDFKTAFRRSYARFQELLRTRTEDEERSRNR---WSGCSA
| |||   .. .  ..       |....||. |   |.   ..| . . .|    .   . |  .| |...   .| .. . |.  . ..     .|  |
kymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.lssepedvleAireaflatheamkkkleeWpktksgllstaGtta

LTCVVTPSTCYLSHVGDVGAILIREDG-----VTKILTRKHDLYNKKERDRVRKSSGVIVKT----------EKCAlVNGA--------LGVTRGLGNIG
 . ... .  |..|||| ...|  ..      ..| ||. |   . .|. |.... | . .           ...   ||         | |.| ||.. 
svviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprle.hngptvideiPFLavaRslGDlW

DGEL-NQSVIIAPKFR--CTCL-TNRDQVLVFASSGLWKVFSAEEVANLV
  .  ... .. |.     . | .|.......|| |||.| ..|.. ..|
synaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvv
subfamily_PHLPP_pd Subfamily PHLPP 409-535 3e-11 35.7 In-house 86-212 (246) alignment 
Range on Protein: 409-535
Range on HMM: 86-212/246.0
GCSALTCVVTPST-----CY---LSHVGDVGAILIREDGvTKILTRKHDLyNKKERDRVRKSSGVIVKTEKcalVNGALGVTRGLGNIgdgELNQSVIIA
| .|| . . ...      .   .  || . |.|||.     .|.... . .| | .|...  ..|   .|   .|| .. || || .    |  .|.  
gsaallilirhdkvdPaksfsLevAsvGtlqavliRngk.klrlsksyvi.ekdelkrikeakaiitednk...ingviestrllGyt...flfPvvlPk

PKFRCTCLTNRDQVLVFASSGLWKVFSAEEVANLV
|..| . ||. | .|.  .  ||.|.| .|... |
phvrevlLteqdellivGnkalWevlsideaveav
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 339-540 3.6e-11 35.4 In-house 35-243 (276) alignment 
Range on Protein: 339-540
Range on HMM: 35-243/276.0
FIGIYDGYCGGTTARKCASQLHQLVSEQLAS-HTDLTKTDfkTAFRRSYARFQELLRTR-TEDEERSRNRWSGCSALTCVVTPST--------CYL--SH
.....||..|  .|      . . .   | |    ||| |        | . . ||      |.. .   . |..|  ..|  .          ||  . 
lfavfdGhaGkGaadaakklfpkelekllksgnysltkqd..dGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvan

VGDVGAILIREDGvTKILTRKHDLYNKKERDRVrKSSGVIVkTEKCALVNGaLGVTRGLGNIGDGELNQSVIIAPKFRC-TCLTNRDQVLVFASSGLWKV
|||  |.| | .  .  |.  |   . .|..|. |  |. . ... . .|| | |.| ||.    |||  .|  |       ||  |. |. || ||| |
vGdssaflsrGne.slelskdhkatdpeekqri.kddGitl.sdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdv

FSAEEVANLVLGFFR
 | ..  . |  .. 
isGkdaiekvkslyd
Subfamily Dicty-PPM1L-like 451-541 5.7e-07 21.6 In-house 178-265 (305) alignment 
Range on Protein: 451-541
Range on HMM: 178-265/305.0
YNKKERDRVRKSSGVIVKTEKCaLVNGALGVTRglgNIGDGELNQSVIIAPKFRCTCLTN-RDQVLVFASSGLWKVFSAEEVANLVLGFFRQ
. ...| |.    . .... .  |||. | . |   ..||..|.. ||  ..     ...  || || |  |||.|.| ..| . |.   |.
fldeiririeslqaalynygel.lvnrllkksr...skGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrd
subfamily_PPM1H_pd Subfamily PPM1H 465-544 9.3e-07 20.9 In-house 267-356 (404) alignment 
Range on Protein: 465-544
Range on HMM: 267-356/404.0
VIVKTEKCALVNGALGVTRGLGNIGDGELNQSVIIAP------KFRCTCL----TNRDQVLVFASSGLWKVFSAEEVANLVLGFFRQIKE
.|. . | | . . .|||||||.     ..... | |      . | . |    ...|.||..|. ||| | | ||||..|  .. ....
lisgegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvep
PP2C_SIG_SM00331 337-533 4.2e-06 19.5 In-house 30-176 (217) alignment 
Range on Protein: 337-533
Range on HMM: 30-176/217.0
SCFIGIYDGYCGGTTARKCASQLHQLVSEQLASHtdltkTDFKTAFRRSYARFQELlrtrtedeerSRNRWSGCSALTCVV--TPSTCYLSHVGDVGAIL
. .. . ||  .|  |  ..|||.... |.| ..     .....|..|    ..|.          . .. .....| ...  . .. .. ..||   .|
rlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..........keekgmfaTlllalydfssgklsyanaGdsrpyl

IREDGVTKILTRkhdlynkkerdrvrkssgvivktekcalvngalG------VTRGLGnigdgelnqsviiaPKFRCTCLTNrDQVLVFASSGLWKV---
.|... ..||.                                         .   .               .. | . |   . .|.... ||. .   
lrdgklveilkd.................................vegaplGlepevs..............vdirelelek.gdllllytDGltearse

--FSAEEVAN
  |  |.. .
kgfaeerlee
subfamily_PPM1G_pd Subfamily PPM1G 319-393 8.9e-06 17.9 In-house 31-99 (473) alignment 
Range on Protein: 319-393
Range on HMM: 31-99/473.0
KNMEDAHHLQDDFLPQTpSCFiGIYDGYCGGTTARKCASQLHQLVSEQLASHTDltktDFKTAFRRSYARFQELL
...||||.   |.  .| |.| ..|||. |   |. .|..| .|. .| . . .    |...|.. ..  . | |
vsqEDahncitdldedt.slf.avyDGHGGkevakyvakklpdllkaqkgykeg....dvekaleeaflalDekl