Gene PP2D1-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PP2D1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP141_AA protein Get Run
NvecP141_AA_167-534 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PP2D1_pd Subfamily PP2D1 301-420 4.1e-62 203.5 In-house 190-309 (492) alignment
Range on Protein: 301-420
Range on HMM: 190-309/492.0
LYIANAGNVRAVLCKGdGSMIRLTQEHTPRNKRERHRVSKYGE-VYKSEKTALVNGLTTNTRGLGNHGDPHLKSSVICQPSVNCVTLDEADQFVILATNG
|||||||||.||||.. |..|.||.|||||||.||.||.|.|. |.||||..||||....||||||.|||.||.|||..|....|.||||.||..||.||
lyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

VWEVFSEEEVILLLEDLMPEL
.|||.|||||. |......  
lWevlseeevlsLvkqtlaiy

0034914 PP2C-like 168-534 5.4e-55 179.3 In-house 9-292 (295) alignment
Range on Protein: 168-534
Range on HMM: 9-292/295.0
HVMGQSTLLNCALAFGICEDKNSrwKTTMEDRHTFCDYFCN-DPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVyrpGLASEGVDAKITTALRET
. .  ...|.. | .|.. |..   . ..||.....  ... ... ..|.||||..| .||   .....| |.. .|..    | ..  .  | .|||..
lellllsslllllrvgvasdqGr..rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl...lllltlsledieealrka

YEDVDRILLYGVDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCkGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSektALVNGLTTNTRGLGNH
.  .|. ||  . .... ..||..||..|.||||||.||.|. ||||.  .| ...|| .|.| |  ||.|. ..|...       |||.   || || .
flaadeellelallrpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdf

GDP------HLKSSVICQPSVNCVTLD-EADQFVILATNGVWEVFSEEEVILLLEDL----MPeldvkeivrrmnnasekkskvakqcntkresakttgs
         .|.  |.. | | ...|. | |.|..||. |.|.|.|.||.. .. .|    ..                                     
dlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld.....................................

sqqeskstsasskssdtisirlpeivsnkgkaatasdslirmeekaqelAKALSERLVQSALMAGSKDNTTVAVILLKG
                                                 .....|.||. || .||.||.|| |. |.|
.................................................leeaaeeLvdlAlargsrDNiTvvvvrlng

subfamily_PP2D1_pd Subfamily PP2D1 181-300 5.9e-52 170.0 In-house 2-155 (492) alignment
Range on Protein: 181-300
Range on HMM: 2-155/492.0
AFGICEDKNSRWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESV-------------------------------YRPG
|.|||||||||||..|||..|..|||.||..|.||...|||||||||...||...|||....|.|                               .|..
avGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirai

LASEGVD---AKITTALRETYEDVDRILLYGVDEDSRNRWSGCSAVTCLLRGNK
|..|.|.   .|...|.|..|...||.| ||..|.||.|||||||.|.||.|||
lkeesvkpefekvkkAfrksylrldrlLsygieeesrvrWsGCsAltllleGnk

PP2Cc_SM00332 183-530 4.8e-47 153.6 In-house 13-274 (274) alignment
Range on Protein: 183-530
Range on HMM: 13-274/274.0
GIceDKNSRWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGlasegvDAKITTALRETYEDVDRILLYGVDEDS
|   ...  |...|||.|     . .  . .||.|||| .|. .|   .| .|| |... ... .        . ... ||.. ....|  .|   .   
gk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel......eddveealkkaflstdeeileeeqske

R-NRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKRERHRVSKYGEVYKSEktaLVNGLTTNTRGLGNHGD----PHLKSSVIC
. |  ||..||..||....||.||.|  |||||...  ...|...|.| ...||.|..| | | . .    |||    .| .| |      .. .  ...
lenalsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyita

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELdvkeivrrmnnasekkskvakqcntkresakttgssqqeskstsasskssdtisirl
.|.|..|||...|.|.|||. |.|.|.|..||. ....|. .                                                          
epdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.........................................................

peivsnkgkaatasdslirMEEKAQELAKALSERLVQSalmAGSKDNTTVAVI
                    ....|| |. | | . ..    ||.||.|| |.
...................ktndpqeaaelldeeairr...ggseDniTvvvv

subfamily_PPM1A_pd Subfamily PPM1A 180-533 1.2e-45 149.1 In-house 12-281 (282) alignment
Range on Protein: 180-533
Range on HMM: 12-281/282.0
LAFGICEDKNsrWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARkvESVYRPGLASEGVDAKITTALRETYEDVDRILLYGVD
| .|. . ..  |...|||.||    . . .. .|||||||  |...| ...|...| . .  |. ..   ...  . ..  |||. . ..|  .    .
lrygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..eeelkeaaleasekdevkealrqgfLaldeairelst

EDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGdGSMIRLTQEHTPRNKRERHRVSKYG-EVYksekTALVNGLTTNTRGLGNHGDPH------LK
. . .  ||. |||.|.. ..|.|||.|  |||||.. |....||..| | ...|..|... | .|     .  |||    .| || .   .       .
dlktadksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkaee

SSVICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMP-ELDVKEIvrrmnnasekkskvakqcntkresakttgssqqeskstsasskssd
  |. .| |...  .| |.|..||  |.|.| |.|||. | .. .    ...|.                                              
qlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev..............................................

tisirlpeivsnkgkaatasdslirmeekaqelakalSERLVQSALMAGSKDNTTVAVILLK
                                     ...||. || .||.|| .| |.|..
.....................................akalvdkalekgsrDNlsvlvvlfa

PP2C Protein phosphatase 2C 187-419 1.3e-42 139.1 Pfam-A 6-231 (255) alignment
Range on Protein: 187-419
Range on HMM: 6-231/255.0
DKNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED-VDRILLYgvDEDS
.........|||.|.... ..    . . .|||||||  |  ||   ... .|.|... .              |   |||....   |  |    ....
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.........kvekalrksfladtdeelks..skan

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSekTALVNGLTTNTRGLGnhgDPHLKS----SVIC
     ||..||..|.||.|||.||.|  |||||..|..  .||. |.| ...||.|....|   .      |||   ..| ||   | .||.     |..
tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalG...dfelkpkeeqlvsa

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPE
.| |. |.|.| |.|.|||. |.|.|.|..|.. | .. . .
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselsk

PP2C Protein phosphatase 2C 187-419 1.3e-42 139.1 In-house 6-231 (255) alignment
Range on Protein: 187-419
Range on HMM: 6-231/255.0
DKNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED-VDRILLYgvDEDS
.........|||.|.... ..    . . .|||||||  |  ||   ... .|.|... .              |   |||....   |  |    ....
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.........kvekalrksfladtdeelks..skan

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSekTALVNGLTTNTRGLGnhgDPHLKS----SVIC
     ||..||..|.||.|||.||.|  |||||..|..  .||. |.| ...||.|....|   .      |||   ..| ||   | .||.     |..
tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalG...dfelkpkeeqlvsa

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPE
.| |. |.|.| |.|.|||. |.|.|.|..|.. | .. . .
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselsk

0049733 PP2C-like 191-533 5.9e-42 136.6 In-house 13-234 (235) alignment
Range on Protein: 191-533
Range on HMM: 13-234/235.0
RWKTTMEDRHTFcdyfcndpQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaseGVDAKITTALRETYEDVDRILLYGVDEDSRNRWSGCS
|.....||.. .        . ..|||.|| .|. |..  .....|.|.. ...             ....|||.... ... ||  . ..   ...|..
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle.........lllldleealrkaflaaneallelalaspelagmgtT

AVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYksektaLVNGLTTNTRGLGnhgDPHLKssvicqPSVNCVTLDEAD
||..||.|.|||.||.|. ||.|.. || ...||..|.| |  || |. ..|...       |.|    || ||   |..||      | | ...|.. |
avvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralG...dlllk......pdvtvlelepgd

qFVILATNGVWEVFSEEEVILLLEDlmPELdvkeivrrmnnasekkskvakqcntkresakttgssqqeskstsasskssdtisirlpeivsnkgkaata
 |..||. |.|.|.|.||.. || .   .|                                                                      
.flllasDGlwdvlsdeeivdllrs..ldl......................................................................

sdslirmeekaqelaKALSERLVQSALMAGSKDNTTVAVILLK
               ... ||||. || .|..||.|| |. |.
...............eeaaerlvelalarggrDNiTvvvvrld

PPM_PTC7 188-415 2.6e-41 134.8 In-house 7-232 (259) alignment
Range on Protein: 188-415
Range on HMM: 7-232/259.0
KNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED--VDRILLYgvDEDS
...... .|||.|.... ..    .   .|||||||  | .||   .....|.|... .              |   |||....    |  |    .|..
afqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele.........klekalrksflaldtdeelks..sean

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGnhgDPHLKS------SV
     ||..||..|..|.|||.||.|. |||||.....  .||. |.| |..||.|... |    ...   |||   ..| .|   | .||.       |
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafG...dfelkpketeeqlv

ICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLED
.. | .. ...|| |.|.|||. |.|.|.|..|.. |  .
saePdisstkideedefliLasdGlwdvvsdqeavdlvrs

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 193-410 4.2e-36 117.5 In-house 17-217 (255) alignment
Range on Protein: 193-410
Range on HMM: 17-217/255.0
KTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVyrpglasegvDAKITTALRETYEDVDRILlygvdeDSRNRWSGCSAV
..||||. .    | ..... ..|.|||. | .||  ...... .|| ...            .|.   .|...|....  .      . | .. |..|.
rptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldln..........nanPvkslkkaykeistqi......serpkfiGttaa

TCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYG-EVYKSEKTALVNGLTTNTRGLGnhgDPHLKSSVICQPSVN-CVTLDEAD
. |. ..| |||| |. |.|||. ||   ||. .| | ...|..|.|. |  | .. .|. |||  . .| ||   | .|.  |. .| ..  ..  . |
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG...dsflePfvvpdPdlsqsleiskkd

QFVILATNGVWEVFSEEEVI
.|.||| .|.|.. |.|| .
kflilacdGiwdlisdeeav

subfamily_PPM1E_pd Subfamily PPM1E 188-426 5.5e-36 117.1 In-house 12-239 (265) alignment
Range on Protein: 188-426
Range on HMM: 12-239/265.0
KNSRwkTTMEDRHTFCDYF----C--NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGlasegvdakitTALRETYEDVDRILLYGVDED
|| |   .|||||  .. .       ....  |||||||. |  ||  .|.  .|.|.|. .    |            .||.|... .|. .|    ..
knkr..rkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqkaere

SRNrwSGCSAVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGnhgDPHLKSSVICQPSV
. .  ||. ||..|.....||.|  |. .|.|.. .|....|.. | | ...|..|. . | .     .  |||  . .| .|   |..||  |. .. |
klk..sGstavvvliekdqlyvaWlGDsqallvr.kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiG...Dvklkpyvsgeadv

NCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELD--VKEIV
  |.||......|||..|.|.|. ||||. |.|. . .     .|. 
aeveldgseeylilacDGlwDvvneeevvklveefladgaedlseva

subfamily_ILKAP_pd Subfamily ILKAP 195-456 5.4e-35 114.0 In-house 18-282 (293) alignment
Range on Protein: 195-456
Range on HMM: 18-282/293.0
TMEDRHTFCDYFCND---P-----QSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpgLASEGVDAKITTALRETYEDVDRILLYGVDEDSRNRW
.|.| |.  . . ..   .     .  ..|||||. |  |.  .|... ... .|. .           . .|  .| .... .|. .|    ..     
emqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.....sdvsakekeikkclvdsfkktdeefLklaskakPvWk

SGCSAVTCLLRGNKLYIANAGNVRAVLCKG--DGS---MIRLTQEHTPRNKRERHRVSKYGEVYKSEKtalVNGLTTNTRGLGNHgdPHLKSSVICQPSV
 |. |...|   | ||.|| |. .|||..   .|.   ...||..||| .. ||.|. | | | .  .   |.|.   .| .|.    . .. ||..| |
dGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgr...vlGvlevsrsiGdg..rfkrlGvistPdv

NCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNASEKKSKVAKQCNTKRESAKTTGSS
. ..|.| |.||.|| .|.|.||| .||.    ... . . .. ... .. |... .    ||     |   |||
kkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgss

subfamily_PPM1G2_pd Subfamily PPM1G2 178-430 1.2e-33 109.3 In-house 17-261 (287) alignment
Range on Protein: 178-430
Range on HMM: 17-261/287.0
CALAFGICEdkNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARkvesvyrpglASEGVDAKITTALRETYEDVDRIL
.. ..| .      .. .||| |.  . .    .|..  .||||||. ||..|  ..| . ...|.           ..  . .....|.... ..|. |
altkvgssa..mqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak..........kksfkegaleqilkdafletDeel

LYgvDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKRERHRVSKYGEVYKSEKtalVNGLTTNTRGLGNHG------D
|   ||  ..  .|. ||. |.. .|||.||||. ||||..    .  |. .| |... |..|. . | . . ..   |||     | ||..        
lk..deklkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfvelnr...vngnLalsralgDfefkknvkk

PHLKSSVICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLL-EDLMPELDVKEIVRRMN
.     | . | | .  ||| | |..|| .|.|.|....||. |. |.|. . ...||.... 
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell

subfamily_PPM1L_pd Subfamily PPM1L 193-418 1.4e-30 99.5 In-house 16-239 (269) alignment
Range on Protein: 193-418
Range on HMM: 16-239/269.0
KTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGLASEGVdaKITTALRETYEDVDRILLYGVDedSRNRWSGCSAV
.  |||| .. .   |. .  |||||||. | .||  . . ... . .|.  . .    .| .  . .. | .    ||. ||  .   . .  .|..|.
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepi..nfsklltdeilsvdekllekak..raediaGttal

TCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGNHGDPHlKSSVICQPSVNCVTLDEA-DQ
  |.....| .|| |. | ||.  .|  | |. .| |.. .||.|. | |     . .  |.|. . .| ||..   . |  || .| . .  ||.   .
ialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.knlviadpdiltfdlddhkpe

FVILATNGVWEVFSEEEVILLLEDLM--P
|.|||..|.|. ||.|| .  . . .  |
flilasdGlwdtfsneeavrfikerlkep

subfamily_PP2D1_pd Subfamily PP2D1 432-535 2.5e-30 98.6 In-house 387-492 (492) alignment
Range on Protein: 432-535
Range on HMM: 387-492/492.0
A--SEKKSKVAKQCNTKREsakTTGSSQQESKSTSASSKSSDTISIRLPEIVSN---KGKAATASDSLIRMEEKAQELAKALSERLVQSALMAGSKDNTT
   ......  |..  . |    |..|..|||....|...|...|||..|...|   .....|.||......||....|.|||||||||||.|||.||.|
ereglseanskkeitynee...dtdksaeeskeaksseekstnrsirveevaenvkaekeeetksdgivdkkekyelaAealserlvqsALlAGsrDnit

VAVILLKGC
|.|||||||
vmvilLkGc

subfamily_PPM1K_pd Subfamily PPM1K 194-413 6.7e-27 87.3 In-house 16-225 (263) alignment
Range on Protein: 194-413
Range on HMM: 16-225/263.0
TTMEDRHTFCDYfcnDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaSEGVDAKITTALRETYEDVDRILLYGVDEDsRNRWSGCSAVT
.  ||| .. .    ||.  ..|||||. |..||    . . ..| |  |         . ..  .. |. |  ... | | . | |      || .|  
aenedriklkel...dpellyvavfdGhaGsaaadfvhdklekilkrllek.......ekdleivlknafeeldkklkrylefsvaea.ellssGttatv

CLLR-GNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEV--YKSEKTALVNGLTTNTRGLGnhgDPHLKS-SVICQPSVNCVTL-DE
.||| |..| .|. |. ||.||. .|   .||..|.|  . |..|. . |    ..|    ||||  . || ||   |  ||.  || .|    . .  .
sllrdGtelvlaslGdsrailcr.nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslG...dldlkryGviatPetkslkvdha

ADQFVILATNGVWEVFSEEEVILLL
|| |..| |.|.  | ...|.  |.
adsflvlitdgisfvvnsqelcdlv

subfamily_KAPP-like_pd Subfamily KAPP-like 208-415 3.2e-23 75.1 In-house 30-230 (266) alignment
Range on Protein: 208-415
Range on HMM: 30-230/266.0
NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpGLASEGVDAK--ITTALRETYEDVDRILlygvdedSRNRWSGCSAVTCLL--RGNKLYI
|  . ..||||||. |  || .. | ||..| ....|        .| | .      |......||  |       .   . |..|  .|.   |.. |.
ncsnialfavfdGhaGkGaadaakklfpkelekllks....tkqddGGdniydqskllenafkevdakl.......kdfeyeGatatlalvwsdGqqryl

--ANAGNVRAVLCKGDGSmIRLTQEHTPRNKRERHRVSKYGeVYKSEKTALVNGLTTnTRGLGNHGDPHLKSSVICQPSV-NCVTLDEADQFVILATNGV
  || |.  | |..|. | . |...|  ....|. |. . | .  |.. . .|||.  .| ||.|   .|   .| .| | | ..|   |.|.|.|..|.
qvanvGdssaflsrGnes.lelskdhkakdpeekqrikddG.itlsdnqtrinGlav.sralGdhfikelniGlisepyvsnrilltpfdkflivasdGl

WEVFSEEEVILLLED
|.| | .. |  .. 
wdvisGkdaiekvks

subfamily_PPM1G_pd Subfamily PPM1G 281-426 7.1e-23 74.3 In-house 290-441 (473) alignment
Range on Protein: 281-426
Range on HMM: 290-441/473.0
DSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYksEKTALVNGLTTNTRGLGNHGD------PHLKSS
..  . ||. || .||...||..||||. |.||.. .|  . |  .| | .. |..|. | |     ..   |||     | ||.|        |.    
eepGedsGttAvvaLlkekklivAnaGDsRcvlsr.nGkAldlslDHkPeDevEleRiekAGGkv..dedgRvnGGLnlsRAlGDhaYkkneeLplkeqm

VICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELD---VKEIV
.   | ..  || |.|.|..||..|.| | . .||.  ... . . .   ..|||
isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 208-415 1.2e-21 69.8 In-house 29-240 (276) alignment
Range on Protein: 208-415
Range on HMM: 29-240/276.0
NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVES-VYRPGLASEGVDAK--ITTALRETYEDVDRILlygvdedSRNRWSGCSAVTCLLRGNK----
|  . ..||||||. |  || .. | ||..| . ..|  |      .| | .   .  | . ...||  |       .   . |..|  .|.  .     
ncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdakl.......kdfeyeGatatlalvwsdGeeqq

------LYIANAGNVRAVLCKGDGSmIRLTQEHTPRNKRERHRVSKYGeVYKSEKTALVNGLTTnTRGLGNHGDPHLKSSVICQPSV-NCVTLDEADQFV
      | .|| |.  | |..|. | . |...|   .  |. |. . | .  |.. . .|||.  .| ||.|   .|   .| .| | | ..|   |.|.
qqqqrylqvanvGdssaflsrGnes.lelskdhkatdpeekqrikddG.itlsdnqtrinGlav.sralGdhfikelniGlisepyvsnrilltpfdkfl

ILATNGVWEVFSEEEVILLLED
|.|..|.|.| | .. |  .. 
ivasdGlwdvisGkdaiekvks

PPM_PTC7_SpoIIE 188-419 1.7e-15 50.5 In-house 7-211 (230) alignment
Range on Protein: 188-419
Range on HMM: 7-211/230.0
KNSRWKTTMEDRHTFCDYFCN---DPQSGFFAVFDGyngataAGTSAKTFPEVLARKVESVYRPGLAsegvdaKITTALRETYEDV-DRILLYgvdedsr
...... .|||.|.... . .   .    .....||       | .|. . . |  ....  ..||       |   .||.... . ...  .       
aaqgarksmedahispansekssggrlalvvgdvdG......hGgraalamgllrtalrelafagle......kpeeilrrlnlalaadlede.......

NRWSGCSAVTCLLRGNK--LYIANAGNVRAVLCKGDGSmirltqehtprnkrERHRVSKYGEVYKSEKTALVNGLTTNTRGLgnhGDPHLKS---SVICQ
.  ||..|| .|.....  ||.||||. ...|...||               ||.|.   | .. .     |.| .. ..     ||  |.     | . 
psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ererivagglpslGilpgrvfgvlavslap...GdllllytDGvveae

PSvNCVTLDEA-DQFVILATNGVWEVFSEEEVILLLEDLMPE
|  .  ....  |.|.|||. |.|.| | .|.. |. | . .
pd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelek

Subfamily Dicty-PPM1L-like 194-442 7.5e-14 44.2 In-house 19-285 (305) alignment
Range on Protein: 194-442
Range on HMM: 19-285/305.0
TTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVEsVYRPGLASE--GVDAKITTALRETYEDVDRILLYGVDEDSRNRWSGC--
   |||.  .    .. .  .| ||||.||  ||  . |   |.. . |  . . | ...   ||   . |..... . |.  |   . |...  .    
kyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvk.enkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlng

SAVTCLLRGNKLYIANAGNVRAVLCKGdGSMIRLTQEHTPR---------------------NKRERHRVSKYGEVYKSEKTALVNGLTTNTRglgNHGD
|. .  |  ...  ..|..  .||. | ..   |.  ..|.                      . .| |.   .       . |||.|    |   . ||
ssasvilerertivstasdtevvlssG.aiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksr...skGd

PHLKSSVICQPSVNCVTLDE-ADQFVILATNGVWEVFSEEEVILLLEDLmpeLDVKEIVRRMNNASEKKSKVAKQ
  ||  || ..  .   . .  |||..|||.|.|||.| ..|.  ...|   |  | . ....   .  |.|  .
knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkel...lrdkssqkkiewdfneisrvive

subfamily_PPM1H_pd Subfamily PPM1H 258-336 1.1e-13 43.7 In-house 135-210 (404) alignment
Range on Protein: 258-336
Range on HMM: 135-210/404.0
KITTALRETYEDVDRILlyGVDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDgSMIRLTQEHTPRNKRERH
 .  || . . ..|  .    .... .   ||.|.  |.  .|||.||||. ||.|.. | ..| | ...||   |.| 
LviGalesaflemDeqi..arereayrikGGCtalvalvllgklYvanaGDsRailvrkd.eiiplsadftPeteRqRl

PP2C_SIG_SM00331 202-436 3.6e-13 42.5 In-house 20-201 (217) alignment
Range on Protein: 202-436
Range on HMM: 20-201/217.0
FCDYFCNDPQSGFFAVFDGYN-GATAAGTSAkTFPEVLARKVESVyrpglasegvdAKITTALRETYEDVDRIllygvdedSRNRWSGCSAVTCL--LRG
. |.. .. .. ...|.||   |. ||  |.  . ..|   ...              ...||... . ...         . .. ...... .|  ...
yydvvklnegrlllvvaDgmGkGlaAaaass.qlrtalrellseg...........eelsqalkrlnraiyee........keekgmfaTlllalydfss

NKLYIANAGNVRAVLCKgDGSMIRLTQEhtprnkrerhrvskygevyksektalvngltTNTRGLGNHGDPHlkssvicqPSVNCVTLDEaDQFVILATN
.||..||||. | .|   || ..  ...                               .... || . ..         . .  ..|.. . ...|.| 
gklsyanaGdsrpyllr.dgklveilkd...............................vegaplGlepevs........vdirelelek.gdllllytD

GVWEV-----FSEEEVILLLEDLMpELDVKEIVR-RMNNASEKK
|..|.     | ||.....||||. .  ..|. . ..... |..
Gltearsekgfaeerleeiledlv.dseaqelaqkiveellela

subfamily_TAB1_pd Subfamily TAB1 287-403 8.2e-12 37.6 In-house 129-259 (333) alignment
Range on Protein: 287-403
Range on HMM: 129-259/333.0
SGCSAVTCLLRGNKLYIANAGNVRAVLCK--GDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGNHGDPHL-------K----S
 | .||  |.  ||||.||.|. ||.|.|      .  | ..||  |. |  |... |   .  |   . |   ||| .|..   ..       .     
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

SVICQPSVNCV-TLDEADQFVILATNGVWEV
 || .|...    .|.. .|..|  .|| . 
PviaePdiqgaypiddityflvlmSdGvykt

subfamily_PPM1D_pd Subfamily PPM1D 209-342 2.1e-11 36.5 In-house 32-168 (309) alignment
Range on Protein: 209-342
Range on HMM: 32-168/309.0
DPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaSEGVDAKITTALRETYEDVDRILLYGVDEDSRNR-----WSGCSAVTCLLRGNKLYI
. .  |.|||||. |  ||    .   .|. .. .            ......|.||.. .. . .    .| ....      .|  | . ..|..|||.
elevafvavfDGHGGkeAakfarehlwsvikkqkkf.......lssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyv

ANAGNVRAVLCKGDG-----SMIRLTQEHTPRNKRERHRVSKYG
|. |. ..|| . .          ||..| | . .|..|. . |
ahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelG

subfamily_PHLPP_pd Subfamily PHLPP 299-409 2.5e-11 35.9 In-house 97-208 (246) alignment
Range on Protein: 299-409
Range on HMM: 97-208/246.0
N--------KLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKrERHRVSKYGEVYKSEKTalVNGLTTNTRGLGNHgdpHLKSSVICQPSVNCVTLDEAD
.        .| .|. |.. |||...    .||.....  .  | .|. .   . . .    .||... || ||     .|  .|. .|.|. |.| | |
dkvdPaksfsLevAsvGtlqavliRngk.klrlsksyviekd.elkrikeakaiitednk..ingviestrllGyt...flfPvvlPkphvrevlLteqd

QFVILATNGVWEVFSEEEV
 ..|.  . .|||.| .|.
ellivGnkalWevlsidea

subfamily_PDP_pd Subfamily PDP 283-340 1.3e-09 30.7 In-house 148-209 (398) alignment
Range on Protein: 283-340
Range on HMM: 148-209/398.0
RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGD--G--SMIRLTQEHTPRNKRERHRVSK
.   ||  |.. |..|..|..||.|  ||||.. .  |  ....|....| .|..| .|. |
lvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikk

subfamily_PDP_pd Subfamily PDP 375-448 2.4e-09 29.8 In-house 270-342 (398) alignment
Range on Protein: 375-448
Range on HMM: 270-342/398.0
VICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNASEKKSKVaKQCNTKRE
.. .| |    | |.|.|..||| | |...|.|||. | .. . . . || |.  ..   .|..| .. . ...
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvv.eelkerkr

DUF2201_N Putative metallopeptidase domain 405-523 4.7e-09 23.1 Pfam-A 122-230 (292) alignment
Range on Protein: 405-523
Range on HMM: 122-230/292.0
SeeevilllEDLMPELDVKEIVRRMNNASekKSKVAKQCNTKRESAKTTGSSQQESKSTSASSKSSDTISIRLPEIVSNKGKAATASDSLIRMEEKAQEL
.        |. . |.|. .. |.... .  |..  || ..... .. .| |.....  |...... . ...  . . .. ...  |..    .|...| 
k........eealaewdaEklYralddkk..kkrsdkqsdsstdggdgsgesegqgeqdskknrkdapekakvralakgesadlaespegksapeaeaee

AKALSERLVQSALMAGSKD
|.  .||| ...  . ...
arewrerlaraleagraaG

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 196-343 2.2e-08 27.0 In-house 5-146 (292) alignment
Range on Protein: 196-343
Range on HMM: 5-146/292.0
MEDRHTFCDYFCNDPQSGFFAVFDGYN--GATAAGTSAKTFpevlARKVESVYRPGlaSEGVDAKITTALrETYEDVDRILLygvdeDsrNRWSGCSAVT
 |..  |. .   .. . . ||.||.   |   |. ...|.      .. ...|.    |  .| .   | ..   .|.  .     |  .| |. .||.
kenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtl....evelleltrql..qelsealllril.diaakldklti.....d..aresattavv

CLL-RGN-KLYIANAGNVRAVLCK----GDGSMIRLTQEHTPRNKRERHRVSKYGE
|   | . .|..|| |. ||.| .     |  .| |...| | .  || |. . | 
carvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGG

subfamily_PPM1H_pd Subfamily PPM1H 348-432 3.4e-07 22.4 In-house 273-366 (404) alignment
Range on Protein: 348-432
Range on HMM: 273-366/404.0
EKTALVNGLtTNTRGLGNHG------DPHLKSSVICQPSVNCVTLDE----ADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNA
 |. |.. . . |||||.|       . ..|  . ..| |. . |..     |. .||||.|.|.| |.|||  ........ . ..  |  . |
kkaRllati.gvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytava

subfamily_PPM1G_pd Subfamily PPM1G 190-273 3.9e-06 19.1 In-house 27-98 (473) alignment
Range on Protein: 190-273
Range on HMM: 27-98/473.0
SRWKTTMEDRHTFCDYFcnDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKveSVYRPGlasegvdaKITTALRETYEDVDRI
  |.  .|| |.    .  | .  .|||.||. |.  |   ||..|..|  .    |. |        ....||.|.. ..|. 
qGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaq..kgykeg........dvekaleeaflalDek

Spectrin Spectrin repeat 79-158 5.6e-06 13.1 Pfam-A 30-105 (105) alignment
Range on Protein: 79-158
Range on HMM: 30-105/105.0
VQDLKIHREFHRALQIFRYTMDNKPNTVKQLVtrrrSLMRKLNENANFENPVSIRKLQKLNAAYELLKSNLVDRWGTLRE
 .||   .. ..... .. ..... . |..|      | .|| ..  ....    .|..|| ..| |.. . .|. .|.|
gkdleevqallkkhkaleaelaaqqervealn....elaeklideghsaseeieerleelnerWeeLlelaaerkqkLee