Gene PP2D1-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PP2D1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP141_AA protein Get Run
NvecP141_AA_167-534 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PP2D1_pd Subfamily PP2D1 301-420 4.1e-62 203.5 In-house 190-309 (492) alignment 
Range on Protein: 301-420
Range on HMM: 190-309/492.0
LYIANAGNVRAVLCKGdGSMIRLTQEHTPRNKRERHRVSKYGE-VYKSEKTALVNGLTTNTRGLGNHGDPHLKSSVICQPSVNCVTLDEADQFVILATNG
|||||||||.||||.. |..|.||.|||||||.||.||.|.|. |.||||..||||....||||||.|||.||.|||..|....|.||||.||..||.||
lyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

VWEVFSEEEVILLLEDLMPEL
.|||.|||||. |......  
lWevlseeevlsLvkqtlaiy
0034914 PP2C-like 168-534 5.4e-55 179.3 In-house 9-292 (295) alignment 
Range on Protein: 168-534
Range on HMM: 9-292/295.0
HVMGQSTLLNCALAFGICEDKNSrwKTTMEDRHTFCDYFCN-DPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVyrpGLASEGVDAKITTALRET
. .  ...|.. | .|.. |..   . ..||.....  ... ... ..|.||||..| .||   .....| |.. .|..    | ..  .  | .|||..
lellllsslllllrvgvasdqGr..rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl...lllltlsledieealrka

YEDVDRILLYGVDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCkGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSektALVNGLTTNTRGLGNH
.  .|. ||  . .... ..||..||..|.||||||.||.|. ||||.  .| ...|| .|.| |  ||.|. ..|...       |||.   || || .
flaadeellelallrpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdf

GDP------HLKSSVICQPSVNCVTLD-EADQFVILATNGVWEVFSEEEVILLLEDL----MPeldvkeivrrmnnasekkskvakqcntkresakttgs
         .|.  |.. | | ...|. | |.|..||. |.|.|.|.||.. .. .|    ..                                     
dlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld.....................................

sqqeskstsasskssdtisirlpeivsnkgkaatasdslirmeekaqelAKALSERLVQSALMAGSKDNTTVAVILLKG
                                                 .....|.||. || .||.||.|| |. |.|
.................................................leeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PP2D1_pd Subfamily PP2D1 181-300 5.9e-52 170.0 In-house 2-155 (492) alignment 
Range on Protein: 181-300
Range on HMM: 2-155/492.0
AFGICEDKNSRWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESV-------------------------------YRPG
|.|||||||||||..|||..|..|||.||..|.||...|||||||||...||...|||....|.|                               .|..
avGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirai

LASEGVD---AKITTALRETYEDVDRILLYGVDEDSRNRWSGCSAVTCLLRGNK
|..|.|.   .|...|.|..|...||.| ||..|.||.|||||||.|.||.|||
lkeesvkpefekvkkAfrksylrldrlLsygieeesrvrWsGCsAltllleGnk
PP2Cc_SM00332 183-530 4.8e-47 153.6 In-house 13-274 (274) alignment 
Range on Protein: 183-530
Range on HMM: 13-274/274.0
GIceDKNSRWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGlasegvDAKITTALRETYEDVDRILLYGVDEDS
|   ...  |...|||.|     . .  . .||.|||| .|. .|   .| .|| |... ... .        . ... ||.. ....|  .|   .   
gk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel......eddveealkkaflstdeeileeeqske

R-NRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKRERHRVSKYGEVYKSEktaLVNGLTTNTRGLGNHGD----PHLKSSVIC
. |  ||..||..||....||.||.|  |||||...  ...|...|.| ...||.|..| | | . .    |||    .| .| |      .. .  ...
lenalsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyita

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELdvkeivrrmnnasekkskvakqcntkresakttgssqqeskstsasskssdtisirl
.|.|..|||...|.|.|||. |.|.|.|..||. ....|. .                                                          
epdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.........................................................

peivsnkgkaatasdslirMEEKAQELAKALSERLVQSalmAGSKDNTTVAVI
                    ....|| |. | | . ..    ||.||.|| |.
...................ktndpqeaaelldeeairr...ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 180-533 1.2e-45 149.1 In-house 12-281 (282) alignment 
Range on Protein: 180-533
Range on HMM: 12-281/282.0
LAFGICEDKNsrWKTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARkvESVYRPGLASEGVDAKITTALRETYEDVDRILLYGVD
| .|. . ..  |...|||.||    . . .. .|||||||  |...| ...|...| . .  |. ..   ...  . ..  |||. . ..|  .    .
lrygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..eeelkeaaleasekdevkealrqgfLaldeairelst

EDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGdGSMIRLTQEHTPRNKRERHRVSKYG-EVYksekTALVNGLTTNTRGLGNHGDPH------LK
. . .  ||. |||.|.. ..|.|||.|  |||||.. |....||..| | ...|..|... | .|     .  |||    .| || .   .       .
dlktadksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkaee

SSVICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMP-ELDVKEIvrrmnnasekkskvakqcntkresakttgssqqeskstsasskssd
  |. .| |...  .| |.|..||  |.|.| |.|||. | .. .    ...|.                                              
qlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev..............................................

tisirlpeivsnkgkaatasdslirmeekaqelakalSERLVQSALMAGSKDNTTVAVILLK
                                     ...||. || .||.|| .| |.|..
.....................................akalvdkalekgsrDNlsvlvvlfa
PP2C Protein phosphatase 2C 187-419 1.3e-42 139.1 Pfam-A 6-231 (255) alignment 
Range on Protein: 187-419
Range on HMM: 6-231/255.0
DKNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED-VDRILLYgvDEDS
.........|||.|.... ..    . . .|||||||  |  ||   ... .|.|... .              |   |||....   |  |    ....
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.........kvekalrksfladtdeelks..skan

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSekTALVNGLTTNTRGLGnhgDPHLKS----SVIC
     ||..||..|.||.|||.||.|  |||||..|..  .||. |.| ...||.|....|   .      |||   ..| ||   | .||.     |..
tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalG...dfelkpkeeqlvsa

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPE
.| |. |.|.| |.|.|||. |.|.|.|..|.. | .. . .
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselsk
PP2C Protein phosphatase 2C 187-419 1.3e-42 139.1 In-house 6-231 (255) alignment 
Range on Protein: 187-419
Range on HMM: 6-231/255.0
DKNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED-VDRILLYgvDEDS
.........|||.|.... ..    . . .|||||||  |  ||   ... .|.|... .              |   |||....   |  |    ....
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.........kvekalrksfladtdeelks..skan

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSekTALVNGLTTNTRGLGnhgDPHLKS----SVIC
     ||..||..|.||.|||.||.|  |||||..|..  .||. |.| ...||.|....|   .      |||   ..| ||   | .||.     |..
tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalG...dfelkpkeeqlvsa

QPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPE
.| |. |.|.| |.|.|||. |.|.|.|..|.. | .. . .
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselsk
0049733 PP2C-like 191-533 5.9e-42 136.6 In-house 13-234 (235) alignment 
Range on Protein: 191-533
Range on HMM: 13-234/235.0
RWKTTMEDRHTFcdyfcndpQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaseGVDAKITTALRETYEDVDRILLYGVDEDSRNRWSGCS
|.....||.. .        . ..|||.|| .|. |..  .....|.|.. ...             ....|||.... ... ||  . ..   ...|..
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle.........lllldleealrkaflaaneallelalaspelagmgtT

AVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYksektaLVNGLTTNTRGLGnhgDPHLKssvicqPSVNCVTLDEAD
||..||.|.|||.||.|. ||.|.. || ...||..|.| |  || |. ..|...       |.|    || ||   |..||      | | ...|.. |
avvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralG...dlllk......pdvtvlelepgd

qFVILATNGVWEVFSEEEVILLLEDlmPELdvkeivrrmnnasekkskvakqcntkresakttgssqqeskstsasskssdtisirlpeivsnkgkaata
 |..||. |.|.|.|.||.. || .   .|                                                                      
.flllasDGlwdvlsdeeivdllrs..ldl......................................................................

sdslirmeekaqelaKALSERLVQSALMAGSKDNTTVAVILLK
               ... ||||. || .|..||.|| |. |.
...............eeaaerlvelalarggrDNiTvvvvrld
PPM_PTC7 188-415 2.6e-41 134.8 In-house 7-232 (259) alignment 
Range on Protein: 188-415
Range on HMM: 7-232/259.0
KNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPglasegvdaKITTALRETYED--VDRILLYgvDEDS
...... .|||.|.... ..    .   .|||||||  | .||   .....|.|... .              |   |||....    |  |    .|..
afqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele.........klekalrksflaldtdeelks..sean

-RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGnhgDPHLKS------SV
     ||..||..|..|.|||.||.|. |||||.....  .||. |.| |..||.|... |    ...   |||   ..| .|   | .||.       |
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafG...dfelkpketeeqlv

ICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLED
.. | .. ...|| |.|.|||. |.|.|.|..|.. |  .
saePdisstkideedefliLasdGlwdvvsdqeavdlvrs
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 193-410 4.2e-36 117.5 In-house 17-217 (255) alignment 
Range on Protein: 193-410
Range on HMM: 17-217/255.0
KTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVyrpglasegvDAKITTALRETYEDVDRILlygvdeDSRNRWSGCSAV
..||||. .    | ..... ..|.|||. | .||  ...... .|| ...            .|.   .|...|....  .      . | .. |..|.
rptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldln..........nanPvkslkkaykeistqi......serpkfiGttaa

TCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYG-EVYKSEKTALVNGLTTNTRGLGnhgDPHLKSSVICQPSVN-CVTLDEAD
. |. ..| |||| |. |.|||. ||   ||. .| | ...|..|.|. |  | .. .|. |||  . .| ||   | .|.  |. .| ..  ..  . |
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG...dsflePfvvpdPdlsqsleiskkd

QFVILATNGVWEVFSEEEVI
.|.||| .|.|.. |.|| .
kflilacdGiwdlisdeeav
subfamily_PPM1E_pd Subfamily PPM1E 188-426 5.5e-36 117.1 In-house 12-239 (265) alignment 
Range on Protein: 188-426
Range on HMM: 12-239/265.0
KNSRwkTTMEDRHTFCDYF----C--NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGlasegvdakitTALRETYEDVDRILLYGVDED
|| |   .|||||  .. .       ....  |||||||. |  ||  .|.  .|.|.|. .    |            .||.|... .|. .|    ..
knkr..rkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqkaere

SRNrwSGCSAVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGnhgDPHLKSSVICQPSV
. .  ||. ||..|.....||.|  |. .|.|.. .|....|.. | | ...|..|. . | .     .  |||  . .| .|   |..||  |. .. |
klk..sGstavvvliekdqlyvaWlGDsqallvr.kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiG...Dvklkpyvsgeadv

NCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELD--VKEIV
  |.||......|||..|.|.|. ||||. |.|. . .     .|. 
aeveldgseeylilacDGlwDvvneeevvklveefladgaedlseva
subfamily_ILKAP_pd Subfamily ILKAP 195-456 5.4e-35 114.0 In-house 18-282 (293) alignment 
Range on Protein: 195-456
Range on HMM: 18-282/293.0
TMEDRHTFCDYFCND---P-----QSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpgLASEGVDAKITTALRETYEDVDRILLYGVDEDSRNRW
.|.| |.  . . ..   .     .  ..|||||. |  |.  .|... ... .|. .           . .|  .| .... .|. .|    ..     
emqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.....sdvsakekeikkclvdsfkktdeefLklaskakPvWk

SGCSAVTCLLRGNKLYIANAGNVRAVLCKG--DGS---MIRLTQEHTPRNKRERHRVSKYGEVYKSEKtalVNGLTTNTRGLGNHgdPHLKSSVICQPSV
 |. |...|   | ||.|| |. .|||..   .|.   ...||..||| .. ||.|. | | | .  .   |.|.   .| .|.    . .. ||..| |
dGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgr...vlGvlevsrsiGdg..rfkrlGvistPdv

NCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNASEKKSKVAKQCNTKRESAKTTGSS
. ..|.| |.||.|| .|.|.||| .||.    ... . . .. ... .. |... .    ||     |   |||
kkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgss
subfamily_PPM1G2_pd Subfamily PPM1G2 178-430 1.2e-33 109.3 In-house 17-261 (287) alignment 
Range on Protein: 178-430
Range on HMM: 17-261/287.0
CALAFGICEdkNSRWKTTMEDRHTFCDYFC---NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARkvesvyrpglASEGVDAKITTALRETYEDVDRIL
.. ..| .      .. .||| |.  . .    .|..  .||||||. ||..|  ..| . ...|.           ..  . .....|.... ..|. |
altkvgssa..mqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak..........kksfkegaleqilkdafletDeel

LYgvDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKRERHRVSKYGEVYKSEKtalVNGLTTNTRGLGNHG------D
|   ||  ..  .|. ||. |.. .|||.||||. ||||..    .  |. .| |... |..|. . | . . ..   |||     | ||..        
lk..deklkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfvelnr...vngnLalsralgDfefkknvkk

PHLKSSVICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLL-EDLMPELDVKEIVRRMN
.     | . | | .  ||| | |..|| .|.|.|....||. |. |.|. . ...||.... 
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell
subfamily_PPM1L_pd Subfamily PPM1L 193-418 1.4e-30 99.5 In-house 16-239 (269) alignment 
Range on Protein: 193-418
Range on HMM: 16-239/269.0
KTTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESVYRPGLASEGVdaKITTALRETYEDVDRILLYGVDedSRNRWSGCSAV
.  |||| .. .   |. .  |||||||. | .||  . . ... . .|.  . .    .| .  . .. | .    ||. ||  .   . .  .|..|.
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepi..nfsklltdeilsvdekllekak..raediaGttal

TCLLRGNKLYIANAGNVRAVLCKGDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGNHGDPHlKSSVICQPSVNCVTLDEA-DQ
  |.....| .|| |. | ||.  .|  | |. .| |.. .||.|. | |     . .  |.|. . .| ||..   . |  || .| . .  ||.   .
ialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.knlviadpdiltfdlddhkpe

FVILATNGVWEVFSEEEVILLLEDLM--P
|.|||..|.|. ||.|| .  . . .  |
flilasdGlwdtfsneeavrfikerlkep
subfamily_PP2D1_pd Subfamily PP2D1 432-535 2.5e-30 98.6 In-house 387-492 (492) alignment 
Range on Protein: 432-535
Range on HMM: 387-492/492.0
A--SEKKSKVAKQCNTKREsakTTGSSQQESKSTSASSKSSDTISIRLPEIVSN---KGKAATASDSLIRMEEKAQELAKALSERLVQSALMAGSKDNTT
   ......  |..  . |    |..|..|||....|...|...|||..|...|   .....|.||......||....|.|||||||||||.|||.||.|
ereglseanskkeitynee...dtdksaeeskeaksseekstnrsirveevaenvkaekeeetksdgivdkkekyelaAealserlvqsALlAGsrDnit

VAVILLKGC
|.|||||||
vmvilLkGc
subfamily_PPM1K_pd Subfamily PPM1K 194-413 6.7e-27 87.3 In-house 16-225 (263) alignment 
Range on Protein: 194-413
Range on HMM: 16-225/263.0
TTMEDRHTFCDYfcnDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaSEGVDAKITTALRETYEDVDRILLYGVDEDsRNRWSGCSAVT
.  ||| .. .    ||.  ..|||||. |..||    . . ..| |  |         . ..  .. |. |  ... | | . | |      || .|  
aenedriklkel...dpellyvavfdGhaGsaaadfvhdklekilkrllek.......ekdleivlknafeeldkklkrylefsvaea.ellssGttatv

CLLR-GNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEV--YKSEKTALVNGLTTNTRGLGnhgDPHLKS-SVICQPSVNCVTL-DE
.||| |..| .|. |. ||.||. .|   .||..|.|  . |..|. . |    ..|    ||||  . || ||   |  ||.  || .|    . .  .
sllrdGtelvlaslGdsrailcr.nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslG...dldlkryGviatPetkslkvdha

ADQFVILATNGVWEVFSEEEVILLL
|| |..| |.|.  | ...|.  |.
adsflvlitdgisfvvnsqelcdlv
subfamily_KAPP-like_pd Subfamily KAPP-like 208-415 3.2e-23 75.1 In-house 30-230 (266) alignment 
Range on Protein: 208-415
Range on HMM: 30-230/266.0
NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpGLASEGVDAK--ITTALRETYEDVDRILlygvdedSRNRWSGCSAVTCLL--RGNKLYI
|  . ..||||||. |  || .. | ||..| ....|        .| | .      |......||  |       .   . |..|  .|.   |.. |.
ncsnialfavfdGhaGkGaadaakklfpkelekllks....tkqddGGdniydqskllenafkevdakl.......kdfeyeGatatlalvwsdGqqryl

--ANAGNVRAVLCKGDGSmIRLTQEHTPRNKRERHRVSKYGeVYKSEKTALVNGLTTnTRGLGNHGDPHLKSSVICQPSV-NCVTLDEADQFVILATNGV
  || |.  | |..|. | . |...|  ....|. |. . | .  |.. . .|||.  .| ||.|   .|   .| .| | | ..|   |.|.|.|..|.
qvanvGdssaflsrGnes.lelskdhkakdpeekqrikddG.itlsdnqtrinGlav.sralGdhfikelniGlisepyvsnrilltpfdkflivasdGl

WEVFSEEEVILLLED
|.| | .. |  .. 
wdvisGkdaiekvks
subfamily_PPM1G_pd Subfamily PPM1G 281-426 7.1e-23 74.3 In-house 290-441 (473) alignment 
Range on Protein: 281-426
Range on HMM: 290-441/473.0
DSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKgDGSMIRLTQEHTPRNKRERHRVSKYGEVYksEKTALVNGLTTNTRGLGNHGD------PHLKSS
..  . ||. || .||...||..||||. |.||.. .|  . |  .| | .. |..|. | |     ..   |||     | ||.|        |.    
eepGedsGttAvvaLlkekklivAnaGDsRcvlsr.nGkAldlslDHkPeDevEleRiekAGGkv..dedgRvnGGLnlsRAlGDhaYkkneeLplkeqm

VICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELD---VKEIV
.   | ..  || |.|.|..||..|.| | . .||.  ... . . .   ..|||
isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 208-415 1.2e-21 69.8 In-house 29-240 (276) alignment 
Range on Protein: 208-415
Range on HMM: 29-240/276.0
NDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVES-VYRPGLASEGVDAK--ITTALRETYEDVDRILlygvdedSRNRWSGCSAVTCLLRGNK----
|  . ..||||||. |  || .. | ||..| . ..|  |      .| | .   .  | . ...||  |       .   . |..|  .|.  .     
ncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdakl.......kdfeyeGatatlalvwsdGeeqq

------LYIANAGNVRAVLCKGDGSmIRLTQEHTPRNKRERHRVSKYGeVYKSEKTALVNGLTTnTRGLGNHGDPHLKSSVICQPSV-NCVTLDEADQFV
      | .|| |.  | |..|. | . |...|   .  |. |. . | .  |.. . .|||.  .| ||.|   .|   .| .| | | ..|   |.|.
qqqqrylqvanvGdssaflsrGnes.lelskdhkatdpeekqrikddG.itlsdnqtrinGlav.sralGdhfikelniGlisepyvsnrilltpfdkfl

ILATNGVWEVFSEEEVILLLED
|.|..|.|.| | .. |  .. 
ivasdGlwdvisGkdaiekvks
PPM_PTC7_SpoIIE 188-419 1.7e-15 50.5 In-house 7-211 (230) alignment 
Range on Protein: 188-419
Range on HMM: 7-211/230.0
KNSRWKTTMEDRHTFCDYFCN---DPQSGFFAVFDGyngataAGTSAKTFPEVLARKVESVYRPGLAsegvdaKITTALRETYEDV-DRILLYgvdedsr
...... .|||.|.... . .   .    .....||       | .|. . . |  ....  ..||       |   .||.... . ...  .       
aaqgarksmedahispansekssggrlalvvgdvdG......hGgraalamgllrtalrelafagle......kpeeilrrlnlalaadlede.......

NRWSGCSAVTCLLRGNK--LYIANAGNVRAVLCKGDGSmirltqehtprnkrERHRVSKYGEVYKSEKTALVNGLTTNTRGLgnhGDPHLKS---SVICQ
.  ||..|| .|.....  ||.||||. ...|...||               ||.|.   | .. .     |.| .. ..     ||  |.     | . 
psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ererivagglpslGilpgrvfgvlavslap...GdllllytDGvveae

PSvNCVTLDEA-DQFVILATNGVWEVFSEEEVILLLEDLMPE
|  .  ....  |.|.|||. |.|.| | .|.. |. | . .
pd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelek
Subfamily Dicty-PPM1L-like 194-442 7.5e-14 44.2 In-house 19-285 (305) alignment 
Range on Protein: 194-442
Range on HMM: 19-285/305.0
TTMEDRHTFCDYFCNDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVEsVYRPGLASE--GVDAKITTALRETYEDVDRILLYGVDEDSRNRWSGC--
   |||.  .    .. .  .| ||||.||  ||  . |   |.. . |  . . | ...   ||   . |..... . |.  |   . |...  .    
kyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvk.enkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlng

SAVTCLLRGNKLYIANAGNVRAVLCKGdGSMIRLTQEHTPR---------------------NKRERHRVSKYGEVYKSEKTALVNGLTTNTRglgNHGD
|. .  |  ...  ..|..  .||. | ..   |.  ..|.                      . .| |.   .       . |||.|    |   . ||
ssasvilerertivstasdtevvlssG.aiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksr...skGd

PHLKSSVICQPSVNCVTLDE-ADQFVILATNGVWEVFSEEEVILLLEDLmpeLDVKEIVRRMNNASEKKSKVAKQ
  ||  || ..  .   . .  |||..|||.|.|||.| ..|.  ...|   |  | . ....   .  |.|  .
knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkel...lrdkssqkkiewdfneisrvive
subfamily_PPM1H_pd Subfamily PPM1H 258-336 1.1e-13 43.7 In-house 135-210 (404) alignment 
Range on Protein: 258-336
Range on HMM: 135-210/404.0
KITTALRETYEDVDRILlyGVDEDSRNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGDgSMIRLTQEHTPRNKRERH
 .  || . . ..|  .    .... .   ||.|.  |.  .|||.||||. ||.|.. | ..| | ...||   |.| 
LviGalesaflemDeqi..arereayrikGGCtalvalvllgklYvanaGDsRailvrkd.eiiplsadftPeteRqRl
PP2C_SIG_SM00331 202-436 3.6e-13 42.5 In-house 20-201 (217) alignment 
Range on Protein: 202-436
Range on HMM: 20-201/217.0
FCDYFCNDPQSGFFAVFDGYN-GATAAGTSAkTFPEVLARKVESVyrpglasegvdAKITTALRETYEDVDRIllygvdedSRNRWSGCSAVTCL--LRG
. |.. .. .. ...|.||   |. ||  |.  . ..|   ...              ...||... . ...         . .. ...... .|  ...
yydvvklnegrlllvvaDgmGkGlaAaaass.qlrtalrellseg...........eelsqalkrlnraiyee........keekgmfaTlllalydfss

NKLYIANAGNVRAVLCKgDGSMIRLTQEhtprnkrerhrvskygevyksektalvngltTNTRGLGNHGDPHlkssvicqPSVNCVTLDEaDQFVILATN
.||..||||. | .|   || ..  ...                               .... || . ..         . .  ..|.. . ...|.| 
gklsyanaGdsrpyllr.dgklveilkd...............................vegaplGlepevs........vdirelelek.gdllllytD

GVWEV-----FSEEEVILLLEDLMpELDVKEIVR-RMNNASEKK
|..|.     | ||.....||||. .  ..|. . ..... |..
Gltearsekgfaeerleeiledlv.dseaqelaqkiveellela
subfamily_TAB1_pd Subfamily TAB1 287-403 8.2e-12 37.6 In-house 129-259 (333) alignment 
Range on Protein: 287-403
Range on HMM: 129-259/333.0
SGCSAVTCLLRGNKLYIANAGNVRAVLCK--GDGSMIRLTQEHTPRNKRERHRVSKYGEVYKSEKTALVNGLTTNTRGLGNHGDPHL-------K----S
 | .||  |.  ||||.||.|. ||.|.|      .  | ..||  |. |  |... |   .  |   . |   ||| .|..   ..       .     
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

SVICQPSVNCV-TLDEADQFVILATNGVWEV
 || .|...    .|.. .|..|  .|| . 
PviaePdiqgaypiddityflvlmSdGvykt
subfamily_PPM1D_pd Subfamily PPM1D 209-342 2.1e-11 36.5 In-house 32-168 (309) alignment 
Range on Protein: 209-342
Range on HMM: 32-168/309.0
DPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKVESvyrpglaSEGVDAKITTALRETYEDVDRILLYGVDEDSRNR-----WSGCSAVTCLLRGNKLYI
. .  |.|||||. |  ||    .   .|. .. .            ......|.||.. .. . .    .| ....      .|  | . ..|..|||.
elevafvavfDGHGGkeAakfarehlwsvikkqkkf.......lssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyv

ANAGNVRAVLCKGDG-----SMIRLTQEHTPRNKRERHRVSKYG
|. |. ..|| . .          ||..| | . .|..|. . |
ahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelG
subfamily_PHLPP_pd Subfamily PHLPP 299-409 2.5e-11 35.9 In-house 97-208 (246) alignment 
Range on Protein: 299-409
Range on HMM: 97-208/246.0
N--------KLYIANAGNVRAVLCKGDGsMIRLTQEHTPRNKrERHRVSKYGEVYKSEKTalVNGLTTNTRGLGNHgdpHLKSSVICQPSVNCVTLDEAD
.        .| .|. |.. |||...    .||.....  .  | .|. .   . . .    .||... || ||     .|  .|. .|.|. |.| | |
dkvdPaksfsLevAsvGtlqavliRngk.klrlsksyviekd.elkrikeakaiitednk..ingviestrllGyt...flfPvvlPkphvrevlLteqd

QFVILATNGVWEVFSEEEV
 ..|.  . .|||.| .|.
ellivGnkalWevlsidea
subfamily_PDP_pd Subfamily PDP 283-340 1.3e-09 30.7 In-house 148-209 (398) alignment 
Range on Protein: 283-340
Range on HMM: 148-209/398.0
RNRWSGCSAVTCLLRGNKLYIANAGNVRAVLCKGD--G--SMIRLTQEHTPRNKRERHRVSK
.   ||  |.. |..|..|..||.|  ||||.. .  |  ....|....| .|..| .|. |
lvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikk
subfamily_PDP_pd Subfamily PDP 375-448 2.4e-09 29.8 In-house 270-342 (398) alignment 
Range on Protein: 375-448
Range on HMM: 270-342/398.0
VICQPSVNCVTLDEADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNASEKKSKVaKQCNTKRE
.. .| |    | |.|.|..||| | |...|.|||. | .. . . . || |.  ..   .|..| .. . ...
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvv.eelkerkr
DUF2201_N Putative metallopeptidase domain 405-523 4.7e-09 23.1 Pfam-A 122-230 (292) alignment 
Range on Protein: 405-523
Range on HMM: 122-230/292.0
SeeevilllEDLMPELDVKEIVRRMNNASekKSKVAKQCNTKRESAKTTGSSQQESKSTSASSKSSDTISIRLPEIVSNKGKAATASDSLIRMEEKAQEL
.        |. . |.|. .. |.... .  |..  || ..... .. .| |.....  |...... . ...  . . .. ...  |..    .|...| 
k........eealaewdaEklYralddkk..kkrsdkqsdsstdggdgsgesegqgeqdskknrkdapekakvralakgesadlaespegksapeaeaee

AKALSERLVQSALMAGSKD
|.  .||| ...  . ...
arewrerlaraleagraaG
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 196-343 2.2e-08 27.0 In-house 5-146 (292) alignment 
Range on Protein: 196-343
Range on HMM: 5-146/292.0
MEDRHTFCDYFCNDPQSGFFAVFDGYN--GATAAGTSAKTFpevlARKVESVYRPGlaSEGVDAKITTALrETYEDVDRILLygvdeDsrNRWSGCSAVT
 |..  |. .   .. . . ||.||.   |   |. ...|.      .. ...|.    |  .| .   | ..   .|.  .     |  .| |. .||.
kenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtl....evelleltrql..qelsealllril.diaakldklti.....d..aresattavv

CLL-RGN-KLYIANAGNVRAVLCK----GDGSMIRLTQEHTPRNKRERHRVSKYGE
|   | . .|..|| |. ||.| .     |  .| |...| | .  || |. . | 
carvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGG
subfamily_PPM1H_pd Subfamily PPM1H 348-432 3.4e-07 22.4 In-house 273-366 (404) alignment 
Range on Protein: 348-432
Range on HMM: 273-366/404.0
EKTALVNGLtTNTRGLGNHG------DPHLKSSVICQPSVNCVTLDE----ADQFVILATNGVWEVFSEEEVILLLEDLMPELDVKEIVRRMNNA
 |. |.. . . |||||.|       . ..|  . ..| |. . |..     |. .||||.|.|.| |.|||  ........ . ..  |  . |
kkaRllati.gvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytava
subfamily_PPM1G_pd Subfamily PPM1G 190-273 3.9e-06 19.1 In-house 27-98 (473) alignment 
Range on Protein: 190-273
Range on HMM: 27-98/473.0
SRWKTTMEDRHTFCDYFcnDPQSGFFAVFDGYNGATAAGTSAKTFPEVLARKveSVYRPGlasegvdaKITTALRETYEDVDRI
  |.  .|| |.    .  | .  .|||.||. |.  |   ||..|..|  .    |. |        ....||.|.. ..|. 
qGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaq..kgykeg........dvekaleeaflalDek
Spectrin Spectrin repeat 79-158 5.6e-06 13.1 Pfam-A 30-105 (105) alignment 
Range on Protein: 79-158
Range on HMM: 30-105/105.0
VQDLKIHREFHRALQIFRYTMDNKPNTVKQLVtrrrSLMRKLNENANFENPVSIRKLQKLNAAYELLKSNLVDRWGTLRE
 .||   .. ..... .. ..... . |..|      | .|| ..  ....    .|..|| ..| |.. . .|. .|.|
gkdleevqallkkhkaleaelaaqqervealn....elaeklideghsaseeieerleelnerWeeLlelaaerkqkLee