Gene PPM1D in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP143_AA protein Get Run
NvecP143_AA_1-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 2-308 5.4e-140 458.8 In-house 3-308 (309) alignment 
Range on Protein: 2-308
Range on HMM: 3-308/309.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEHVVKAIKEGFMATHRSMWKVLENWPKTRH
.|.|||.|||||.|||...| ............||.||||||||.||| |||..||..||||..|.||.||.|..||.|.|.|||..|.|.||.||||..
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

GLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARNGVYRVAWERPVCHgHRGPmrrsTKTER
||.||.|||..|.|||..|..|||||||..||..|||..|.|.| .||.|||||.|.||.|||.|||.| |..||.||.|.|| .. |.||    |....
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprle.hngp....tvide

VPFLAVSRSLGDLWSFDYFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWH----PSYLPRLVSKALSRWRARKLRA
.|||||.||||||||.....|||||||.|||||.|..|...|..|||||||| |..|.|||..|..........     |. ..||..||.|||..||||
iPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNTSVIVVSFE
||.||||| .|
Dnvsvivvile
PPM_PTC7 3-300 1.8e-66 217.3 In-house 3-259 (259) alignment 
Range on Protein: 3-300
Range on HMM: 3-259/259.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMATHRSMWKVLenwPKTRHg
....| || ||.|||   .|.. .  ....  || |||||||||||| .||..|.| .|... |....   . ||....|.| .  ... .   ..... 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLARnGVYRVAWErpvchghrgpmrrstkterv
.|||||.| .|..|.|.|..||.||||.|||....         .|| ||||. . |..|||..||||    |. || .                     
epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnv.gngrvngv....................

pfLAVSRSLGDLWSFDYFRGEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVmwYSCVNTWhpsyLPRLVSKALSRWRARKLRADNT
  |||||..||.........|..||. ||... .|..  |...|||||||| || ...||  |   |... .     |. ....| ... .. ..||.
..lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlv..rselskk....dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 3-300 8.3e-65 211.9 Pfam-A 3-255 (255) alignment 
Range on Protein: 3-300
Range on HMM: 3-255/255.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMAtHRSMWKVLenwPKTRHg
|.... || ||.|||   .| . .  ....  ||.|||||||||||| .||..|.| .|.|. |....   | ||....|.| . .... .   .|... 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLArngVYRVAWErpvchghrgpmrrstkterv
.||.||.| .|..|||.|..||.|||| |||..|           || ||||. . |..|||..||||     . || .                     
epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs....................

pfLAVSRSLGDLWSFDYFrgEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVMwySCVNTWHpsyLPRLVSKALSRWRARKLRADNT
  |||||.|||.......  |..||. |||.. ....  |. .|||||||| |.....||  |   |... ..    |. ....| ... .. ..||.
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvr..selskkk...spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 3-300 8.3e-65 211.9 In-house 3-255 (255) alignment 
Range on Protein: 3-300
Range on HMM: 3-255/255.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMAtHRSMWKVLenwPKTRHg
|.... || ||.|||   .| . .  ....  ||.|||||||||||| .||..|.| .|.|. |....   | ||....|.| . .... .   .|... 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLArngVYRVAWErpvchghrgpmrrstkterv
.||.||.| .|..|||.|..||.|||| |||..|           || ||||. . |..|||..||||     . || .                     
epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs....................

pfLAVSRSLGDLWSFDYFrgEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVMwySCVNTWHpsyLPRLVSKALSRWRARKLRADNT
  |||||.|||.......  |..||. |||.. ....  |. .|||||||| |.....||  |   |... ..    |. ....| ... .. ..||.
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvr..selskkk...spmeaaeelvdeaiargsedni
0034914 PP2C-like 2-309 1.9e-58 190.6 In-house 22-292 (295) alignment 
Range on Protein: 2-309
Range on HMM: 22-292/295.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQ----RGFYSSDPEHVVKAIKEGFMATHRSMWKVLENwp
||..  .|| || .||. .....  .  .  ......||||||| .|| .|...|.|.....      ......| ...|....|.|... ... ...  
rvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall..

ktrHGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLArngV--Yrvawerpvchghrgpmrr
   .   ..||||..|..|||.|..||.|||| ||| ..       |...|| ||||  . |..||...|| |        .                  
...rpelagsGtTavvalirgnklyvanvGDSravllrng......elvqltvdhkpvnelererilsaggavsh...grvn..................

stktervPFLAVSRSLGDLWSF---DYFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALSrwra
       ..|||.|.||| . .    ..  |..||..|||.|.....  |. ..|||||||.|. ....|..|. .   ..       .||  ||.    
.......gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla....

rKLRADNTSVIVVSFED
 .   ||..|.|| ...
.rgsrDNiTvvvvrlng
PP2Cc_SM00332 6-305 5.9e-52 169.7 In-house 15-274 (274) alignment 
Range on Protein: 6-305
Range on HMM: 15-274/274.0
EAHQGGRKCMEDFTSILFDRQhigKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRSMWKVLENWPKTRhglp
 . || || |||.. . .| .   .  . .|..||||||| |.| |....|.| .|..  . ...  . | .|.|..| .|.  ...  ... . .    
ssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen....

STSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgtkrleAYPLTDDHKPEAPHEKRRIEDLGGsvlarngvyrvawerpvchghrgpmrrSTKTERVPF
..||.|..|..... ...||.|||| |||....       | .|. ||||| . |..||.. ||                           ... .||  
alsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkagg...........................vvekgrvng

-LAVSRSLGDLWSFD-YFRGEFVVSPVPDVKVYTInPATDKHVILASDGLWGVVQPDDAVRCVMWYS--CvntwhPSYLPRLVSKALSRWRAR-KLRADN
 |||||..|| .  .     | .... ||||| |.    |. .|||||||| |. ....| .|..              |  ... | .  .| .  .||
glavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairrggseDn

TSVIVV
..|.||
iTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 2-308 9.7e-45 146.1 In-house 13-281 (282) alignment 
Range on Protein: 2-308
Range on HMM: 13-281/282.0
RVSSEAHQGGRKCMEDFTSILfdrQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGF-----YSSDPEHVVKAIKEGFMATHRSMWKVLENW
|.. .. || |..|||  ..    ...|.  ...| ||||||.|.|.| .. . | |.| ..  .      .|. ..| .|...||.|.. .. .  .. 
rygvssmqgwrvemEDahtvv...aslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdl

PKTrhglpSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLarngVYRVAWErpvchghrgpmrrs
 ..       ||.|....... .....|..||| |||....      .|  ||.||||. |.||.|||. ||||.    | ||                 
kta.....dksGsTavtvlvsekhliianlGDsRavlcrng......kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa..............

tktervpfLAVSRSLGDLwSFDY----FRGEFVVSPVPDVKVYTINPATDkHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALsrwra
        |||||.|||  ...        |  ||..|.|..  ..   | ...||.||.| |.. ...|  |     |..   .   .|| |||     
........LAvsRalGDy.eykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkal.....

RKLRADNTSVIVVSFE
.|   || ||.|| |.
ekgsrDNlsvlvvlfa
0049733 PP2C-like 3-308 1.4e-43 141.9 In-house 5-234 (235) alignment 
Range on Protein: 3-308
Range on HMM: 5-234/235.0
VSSEAHQGG-RKCMEDFTSIlfdrqhigkdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRSMWKVLENWPktrh
|.   ..|  || .||.  .           |....||.||||| .|. .|...|.||....  ... .......|... |.|... ...  ...|    
vgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp....

gLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVlarngvyrvawerpvchghrgpmrrstktER
   ...|||..|....|.|..||.|||| |.| ...      ....|| ||.|  . |..||...|| |                               
.elagmgtTavvalldggklyvanvGDsrayllrdg......klvqltedhspvnelerqriitaggav.............................rv

VPFLAVSRSLGDLWSFdyfrgefvvspvPDVKVYTINPATdkHVILASDGLWGVVQPDDAVRCVMWyscvnTWHPSYLPRLVSKALSRWRArklraDNTS
 . ||..|.||||.              ||| |....|     ..|||||||.|. ....|....      .    .  |||. ||.|.       ||..
pgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggr.....DNiT

VIVVSFE
|.|| ..
vvvvrld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 4-272 5.3e-35 113.9 In-house 9-227 (255) alignment 
Range on Protein: 4-272
Range on HMM: 9-227/255.0
SSEAHQGGRKCMEDFTSILFDRQhigKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEhvvKAIKEGFMATHRSMwkvlenwpktrHGL
.     | |  ||| ..|    .   .. .. ..|.|||||||.|| ||  .|   ...    ....|.   |..|. . ...  .              
gfsdmiGrrptmedelviyGsfr...dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi...........ser

PSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLeayplTDDHKPEAPHEKRRIEDLGGSVLARngvyrvawerpvchghrgpmrrsTKTERVP
|   ||| ....| ..|...| |||| .||. |.  .|||     . ||||  ..|..||..||| |..                        ..| || 
pkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrl.....sldhkPseeseekriselGGtvvst.......................vvtsrvn

-FLAVSRSLGDLwsfdyFRGEFVVsPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVN
  |||||.|||      |   ||| | ||..    .  .||..||| ||.| ..  ..||  |.  |  .
GtlavsralGds.....flePfvv.pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpe
PPM_PTC7_SpoIIE 3-265 7.7e-35 113.8 In-house 3-205 (230) alignment 
Range on Protein: 3-265
Range on HMM: 3-205/230.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREaaVFARSRLWETIKKQRgFYSSDpeHVVKAIKEGFMATHRSMWKVlenwpktrhg
... | || ||.|||   .... .  ...   ......||||||.   .|...|........ | ...   . ....... | .. ...           
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede..........

lPSTSGTTVTVIIIRGHK--MFVAHVGDSGAVLASKEPGtkrleaypltddhkpeaphEKRRIeDLGGSV-L-ARNGvyRVAWErpvchghrgpmrrstk
 ||.||.|..|..|....  . ||..||| ..| ....|                   |..|| ..|| . | ...|  ||...                
.psssgaTavvalidpstgklyvanaGdsppllvrddgg...................ereri.vagglpslGilpg..rvfgv................

tervpfLAVSRSLGDLWSFDyfrGEFVVSPVPDvKVYTINPATDKHVILASDGLWGVVQPDDAVRCV
      ||||.. |||. ..    ..||.. ||  . .. .  |...|||||||| |. |...|. |
......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlv
subfamily_PPM1E_pd Subfamily PPM1E 3-179 1.2e-31 102.8 In-house 6-167 (265) alignment 
Range on Protein: 3-179
Range on HMM: 6-167/265.0
VSSEAHQGGRKCMEDFTSILFD-RQHIG--KDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFySSDPEhvvKAIKEGFMATHRSMWKvlenwPKT
||..| .. |. |||   .| |  . ..  ..  .|| |||||||| ||| .| ..|.|.. .|  .  .||.   .|.||.| .| ... .       .
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa...ealkeafkltDerflq.....kae

RHGLpsTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKepgtkrLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARnGVYRV
| .|  .||.|  |..|......|| .||| |.| .|       ||  |.. |||| . ||.|||..|| |.   |..||
rekl..ksGstavvvliekdqlyvaWlGDsqallvrk......geavqlmkpHkPeredEkkRieeagGlvvvi.gawRv
subfamily_PPM1G2_pd Subfamily PPM1G2 2-171 8.9e-28 90.0 In-house 20-173 (287) alignment 
Range on Protein: 2-171
Range on HMM: 20-173/287.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYssdPEHVVKAIKEGFMATHRSMWKVlenwpktRH
.|.| | || |  |||   .  .  .   |   |..||||||||...| .| ..| ..|.|.. |     ... ...|..|..| ... |        ..
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.......ek

GLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgTKRLeayplTDDHKPEAPHEKRRIEDLGGSVL
   ...|.| .|..|. .|..|| .||| |||.||   .| |     . ||||.  .||.||.. || | 
lkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkal.....sfDhkPqeesekkriiaagGfve
subfamily_PPM1L_pd Subfamily PPM1L 4-180 1.7e-24 79.6 In-house 8-173 (269) alignment 
Range on Protein: 4-180
Range on HMM: 8-173/269.0
SSEAHQGGRKCMEDFTSILfdrQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEHVV-----KAIKEGFMATHRSMWKVLENwpk
.  . .| |. |||   |    ..| ...|. |.||||||||  || ||...| ..||..   . .| |. .     | ...  ..  . . .....   
avysvlGrrprmedrfeie...ediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakr...

TRhglpSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpGtkrlEAYPLTDDHKPEAPHEKRRIEDLGGsVLARNGVYRVA
.      ..|||. . ....... || ||||  ||  |. |    .| ||. ||||. ..|..||.. ||  .| .||.|||
ae....diaGttalialvqesdlivanvGdsrGvlydkr.G....kaiplsfdhkpqqvkerkrikkaGG.fiafrGvwrva
subfamily_ILKAP_pd Subfamily ILKAP 8-171 6e-22 71.1 In-house 12-177 (293) alignment 
Range on Protein: 8-171
Range on HMM: 12-177/293.0
HQGGRKCMEDFTSILFDRQ---HIGKD--IGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRSMWKvlENWPKTRHG
 .| |. |.| . || | .   .  |.     .. ||||||.|. |. || ..| ..|...  . .||     | ||  .. ...   .  |   . ...
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktde..efLklaska

LPS-TSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVL
 |.   |.|.||...    ..|| .||| |||. |.. .... . .|| ||.|    |..||.  ||.| 
kPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 36-216 7.7e-21 67.9 In-house 22-185 (292) alignment 
Range on Protein: 36-216
Range on HMM: 22-185/292.0
F-IAVFDGHG--GREAAVFARSRLWETIKKQRGFYSSDPEHVVKAIKeGFMAThrsmWKVLenwpKTRHGLpsTSGTTVTVIIIRGH-KMFVAHVGDSGA
|  ||.||||  |.. | .| ..|   . .        .| ... |     |     .. |       ...   ..|.|.  ..|   ....|.|||| |
flaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaak....ldkl....tidare..sattavvcarvrddralilanvGdsra

VLASKePGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARngvyRVawerpVCHGHRGPMRRSTKTERVPFLAVSRSLGDLWS
.|     |  . |  ||. ||||| | |..||   || |       ||       .|.||. |   . ..   ||.||.|||.  
llgrc.lggsdyeliPlsrdhkPedPderarilraGGrvept....rv.....rgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_PPM1K_pd Subfamily PPM1K 35-171 7.3e-19 60.9 In-house 32-157 (263) alignment 
Range on Protein: 35-171
Range on HMM: 32-157/263.0
AFIAVFDGHGGREAAVFARSRLWETIKKQRgfysSDPEHVVKAIKEGFMATHRSMWKVLENW-PKTrhgLPSTSGTTVTVIIIR-GHKMFVAHVGDSGAV
 ..||||||.|  || |. ..| ...|.         . . . .|. |   .. . . ||   ...      .|||| || ..| | .. .| .||| |.
lyvavfdGhaGsaaadfvhdklekilkrll....ekekdleivlknafeeldkklkrylefsvaea...ellssGttatvsllrdGtelvlaslGdsrai

LASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVL
|  .       .|  ||.||.||  .||.||   |||| 
lcrnG......kakkltrdhdPeleeekerikaagGsve
subfamily_PPM1G_pd Subfamily PPM1G 105-170 4.2e-14 45.4 In-house 294-353 (473) alignment 
Range on Protein: 105-170
Range on HMM: 294-353/473.0
STSGTTVTVIIIRGHKMFVAHVGDSGAVLASKepgtkrLEAYPLTDDHKPEAPHEKRRIEDLGGSV
. |||| .|......|..|| .||| .||...       .|  |  ||||| ..|..|||  || |
edsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkv
subfamily_PPM1G_pd Subfamily PPM1G 4-89 3.7e-11 35.7 In-house 22-99 (473) alignment 
Range on Protein: 4-89
Range on HMM: 22-99/473.0
SSEAHQGGRKCMEDFTSILFDRQHigkdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpehVVKAIKEGFMATHRSM
.  | || |. .||    . | ..       .. ||.|||||.| |..  ..| . .|.|.|.   |   | ||..| |.|  ...
gasamqGwrvsqEDahncitdlde.....dtslfavyDGHGGkevakyvakklpdllkaqkgykegd...vekaleeaflalDekl
subfamily_KAPP-like_pd Subfamily KAPP-like 26-170 1.4e-10 33.7 In-house 26-161 (266) alignment 
Range on Protein: 26-170
Range on HMM: 26-161/266.0
QHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRsMWKVLENWPKTrHGLpSTSGTTVTVIIIRGHKMFVA-
... .    |..|||||| |. ||. |.  . . ..|.    |.. ..  . | .     .  . | ...  |  .     . .|....   |.. ..  
kklsncsnialfavfdGhaGkGaadaakklfpkelekl..lkstkqddGGdniydqskllen.afkevdaklkd.fey.eGatatlalvwsdGqqrylqv

-HVGDSGAVLASkepGTkrlEAYPLTDDHKPEAPHEKRRIEDLGGSV
  |||| | |.    |    |.  |. ||| . |.||.|| | | ..
anvGdssaflsr...Gn...eslelskdhkakdpeekqrikddGitl
subfamily_PPM1G2_pd Subfamily PPM1G2 204-307 2.1e-10 33.0 In-house 180-286 (287) alignment 
Range on Protein: 204-307
Range on HMM: 180-286/287.0
FLAVSRSLGDLwSFDYFR----GEFVVSPVPDVKVYTINpATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALSRWRA-RKLRAD
 ||.||.|||  .|         | .|  |||| |  ..   |  ..|| ||.| |.. .. |  |      ..   .   .|..|.|..      . .|
nLalsralgDf.efkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcD

NTSVIVVSF
| .|..|..
nmtvvivvl
subfamily_PDP_pd Subfamily PDP 100-164 2.8e-10 32.9 In-house 144-208 (398) alignment 
Range on Protein: 100-164
Range on HMM: 144-208/398.0
R-HGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKrLEAYPLTDDHKPEAPHEKRRIE
| . |...||.. ..  |.|....|| .||. |||...|. ..  || .|. |.  . ..| .||.
reallvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRik
PP2C_SIG_SM00331 33-260 6.4e-10 31.9 In-house 29-168 (217) alignment 
Range on Protein: 33-260
Range on HMM: 29-168/217.0
GQAFIAVFDGHG-GREAAVFARS--RLWETIKKQRGFYSSDPEHVVKAIKEGfmathrsmwkvlenwpktrhGLPSTSGTTVTVIII--RGHKMFVAHVG
|. ...|.||.| | .||.....   . ... ...   |. .... .||.|                        . ...|......  ...|. .|..|
grlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....................keekgmfaTlllalydfssgklsyanaG

DSGAVLASKEPGTKRLEAypltddhkpeaphekrriedlggsvlarngvyrvawerpvchghrgpmrrstktervpflAVSRSLGDLWSFDyfrgefvvs
||  .|  ..  ...|..                                                              .. ||  ....         
dsrpyllrdgklveilkd............................................................vegaplGlepevs.........

pvpdVKVYTINPATDKHVILASDGLWGVVQPDD
    |......   .  ..|..|||. ......
....vdirelelekgdllllytDGltearsekg
subfamily_KAPP-like_pd Subfamily KAPP-like 199-306 8.9e-10 31.0 In-house 165-265 (266) alignment 
Range on Protein: 199-306
Range on HMM: 165-265/266.0
TERVPFLAVSRSLGDLWSFDYFRGefvVSPVPDVK-VYTINPaTDKHVILASDGLWGVVQPDDAVRCVMW-YSCVNTwHPSYLPRLVSKALSRWRARklr
  |.  |||||.||| .  .   |   ..  | |   ... |  ||..|.|||||| |.. .||.  |   |   .| . .    |.  |.   .|.   
qtrinGlavsralGdhfikelniG...lisepyvsnrilltp.fdkflivasdGlwdvisGkdaiekvkslydqqat.edkmasslletaiqsikak...

aDNTSVIVVS
 || ||||| 
.dnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 199-306 9e-10 30.9 In-house 175-275 (276) alignment 
Range on Protein: 199-306
Range on HMM: 175-275/276.0
TERVPFLAVSRSLGDLWSFDYFRGefvVSPVPDVK-VYTINPaTDKHVILASDGLWGVVQPDDAVRCVMW-YSCVNTwHPSYLPRLVSKALSRWRARklr
  |.  |||||.||| .  .   |   ..  | |   ... |  ||..|.|||||| |.. .||.  |   |   .| . .    |.  |.   .|.   
qtrinGlavsralGdhfikelniG...lisepyvsnrilltp.fdkflivasdGlwdvisGkdaiekvkslydqqat.edkmasslletaiqsikak...

aDNTSVIVVS
 || ||||| 
.dnvsvivvk
PP2C_2 Protein phosphatase 2C 8-257 4.1e-09 29.0 Pfam-A 5-182 (212) alignment 
Range on Protein: 8-257
Range on HMM: 5-182/212.0
HQGGRKCMEDFTSilfdrqhIGKDIGQAFIAVFDGHGGREA----AVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRsmwkvLENWPKTRHG
|. ..|. .| .        | .. .  ..|| ||.| ..     | .| . . |...|.    | .  |.....|...  |. .     |..  . .. 
hrrkgkpcqDala.......ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.....lkqeaeaqqe

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASkepgtKRLEAYPLTDDHKPEAPHEKRRIEDL--GGSVlarngvyrvawerpvchghrgpmrrstkte
 ..  .||... .|..........||...|. .     .  |. .|..... |.  | ... .   ....                              
elkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllgepdsgeyanettfltsedaeeel..............................

rvpflavsrslgdlwsfdyfrgefvvspvpdvKVYTINPATDKHVILASDGLWGVVQ
                                .. ...    ....| .||..  ..
................................rirrlklepgdalllmTDGvsdslr
PP2C_2 Protein phosphatase 2C 8-257 4.1e-09 29.0 In-house 5-182 (212) alignment 
Range on Protein: 8-257
Range on HMM: 5-182/212.0
HQGGRKCMEDFTSilfdrqhIGKDIGQAFIAVFDGHGGREA----AVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRsmwkvLENWPKTRHG
|. ..|. .| .        | .. .  ..|| ||.| ..     | .| . . |...|.    | .  |.....|...  |. .     |..  . .. 
hrrkgkpcqDala.......ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.....lkqeaeaqqe

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASkepgtKRLEAYPLTDDHKPEAPHEKRRIEDL--GGSVlarngvyrvawerpvchghrgpmrrstkte
 ..  .||... .|..........||...|. .     .  |. .|..... |.  | ... .   ....                              
elkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllgepdsgeyanettfltsedaeeel..............................

rvpflavsrslgdlwsfdyfrgefvvspvpdvKVYTINPATDKHVILASDGLWGVVQ
                                .. ...    ....| .||..  ..
................................rirrlklepgdalllmTDGvsdslr
subfamily_PPM1E_pd Subfamily PPM1E 205-307 5.4e-09 28.6 In-house 171-262 (265) alignment 
Range on Protein: 205-307
Range on HMM: 171-262/265.0
LAVSRSLGDLWSFDYfrgefvVSPVPDVKVYTINPaTDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPrlvsKALSRWRARKLRADNTSVIV
|.|||..||  . .|      ||  .||  ....  ... .|||.|||| ||.....|. |  .   .. . | ..    | |      .  .|| .|.|
LsvsRaiGDvklkpy......vsgeadvaeveldg.seeylilacDGlwDvvneeevvklveefladgaedlseva....kllveaakeagssDnitvvv

VSF
| .
vfl
subfamily_ILKAP_pd Subfamily ILKAP 204-266 1.5e-08 27.2 In-house 184-240 (293) alignment 
Range on Protein: 204-266
Range on HMM: 184-240/293.0
FLAVSRSLGDLwsfdYFRGEFVVSpVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVM
 | ||||.||      |..  |.| .||||  ....  |..|.|| |||| |.. |..|. ..
vlevsrsiGdg....rfkrlGvis.tPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfil
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 26-170 2.4e-08 26.2 In-house 25-171 (276) alignment 
Range on Protein: 26-170
Range on HMM: 25-171/276.0
QHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKqrgFYSSDPEHVVKaIKEGFMATHrSMWKVLENWPKT-RHGLP--STSGTTVTVII--IRG--
... .    |..|||||| |. ||. |.  . . ..|   .  |    . |  ..|    .  . |.| .  |     |      |.| |. .    |  
kdlsncsnialfavfdGhaGkGaadaakklfpkelek...llksgnysltk.qddGGdniy.dqskllldlfkevdaklkdfeyeGatatlalvwsdGee

----HKMF--VAHVGDSGAVLASkepGTkrlEAYPLTDDHKPEAPHEKRRIEDLGGSV
    .. .  || |||| | |.    |    |.  |. ||| . |.||.|| | | ..
qqqqqqrylqvanvGdssaflsr...Gn...eslelskdhkatdpeekqrikddGitl
subfamily_TAB1_pd Subfamily TAB1 107-167 3.3e-08 25.7 In-house 129-186 (333) alignment 
Range on Protein: 107-167
Range on HMM: 129-186/333.0
SGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgtkRLEAYPLTDDHKPEAPHEKRRIEDLG
 |||  |..|   |..|| |||| |.|  ...     .   |  ||. . ..|  |..|||
gGttAvvalifnnkLyVaNvGdsrAllvkrke...sekvkqLsvdHttdNedEllRlkdLG
subfamily_PPM1L_pd Subfamily PPM1L 204-266 3.8e-08 25.9 In-house 175-233 (269) alignment 
Range on Protein: 204-266
Range on HMM: 175-233/269.0
FLAVSRSLGDLWsfdyFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVM
 ||.||.|||      .. . .| . ||.  . ..    . .||||||||     ..||| ..
vlatsralGdyp....lkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfik
subfamily_PDP_pd Subfamily PDP 229-270 1.2e-07 24.2 In-house 273-313 (398) alignment 
Range on Protein: 229-270
Range on HMM: 273-313/398.0
VPDVKVYTINPaTDKHVILASDGLWGVVQPDDAVRCVMWYSC
 |.|  . ... .|| ..||.|||| .......|. |. . .
ePevtshklre.ndkFLvlatDGLwdllsneevvslVgehla
subfamily_PP2D1_pd Subfamily PP2D1 101-175 2.3e-07 22.9 In-house 171-238 (492) alignment 
Range on Protein: 101-175
Range on HMM: 171-238/492.0
HGLPSTSGTTVTViIIRGHKMFVAHVGDSGAVLASKepGtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLARNG
.||   | ..     .    ...|..|. .|||  .  |    .|. || .| |. ..|..|.|  |..| . . 
eGlekesngsevh.leelgvlyianaGnvqAvLcre..G....kaiiLtreHtprnkkERtRvekagsvvvksek
Subfamily Dicty-PPM1L-like 204-267 4e-07 22.1 In-house 204-261 (305) alignment 
Range on Protein: 204-267
Range on HMM: 204-261/305.0
FLAVSRSLGDLWSfdyfrGEFVVsPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMW
.| .||| ||         |.|. | .| ... .. | |. ..|| |||| |.. .| |  |  
llkksrskGdknl.....kelvi.PnndspllvvakanDqflvlatdGlwevlsyqdvveevke
subfamily_PPM1H_pd Subfamily PPM1H 205-266 1.3e-06 20.4 In-house 281-348 (404) alignment 
Range on Protein: 205-266
Range on HMM: 281-348/404.0
LAVSRSLGD--LWSFD-YFRGEFVVSPVPDVKVYTIN---PATDKHVILASDGLWGVVQPDDAVRCVM
..|.| |||  |   |       ..||||.|.|. ..     .|. .|||.|||| |.. ... . | 
igvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivr
Subfamily Dicty-PPM1L-like 34-135 2.1e-06 19.8 In-house 37-143 (305) alignment 
Range on Protein: 34-135
Range on HMM: 37-143/305.0
QAFIAVFDGHGGREAAVFARSRLWET----IKKQRGFYSSDPEHV----VKAIKEGFMATHRSMWKVLENWPKTrHGLpSTSGTTVTViIIRGHKMFVAH
. .  |||||.|  || ... .| |     .|. .  ||..   |    ..|||.....| .|. .  |   |   |  .  |.. .| |.   .. |. 
lslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkk.aGt.tlngssasv.ilerertivst

VGDSGAVLAS
 .|. .||.|
asdtevvlss
subfamily_PPM1H_pd Subfamily PPM1H 101-166 4.4e-06 18.7 In-house 156-213 (404) alignment 
Range on Protein: 101-166
Range on HMM: 156-213/404.0
HGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGtkrleaYPLTDDHKPEAphEKRRIEDL
.    . | |. | ..   |..||  ||| |.|  |.         ||  |. ||.  |..|.  |
eayrikGGCtalvalvllgklYvanaGDsRailvrkdei......iplsadftPet..eRqRlqel
subfamily_PPM1G_pd Subfamily PPM1G 206-264 5.8e-06 18.6 In-house 364-424 (473) alignment 
Range on Protein: 206-264
Range on HMM: 364-424/473.0
AVSRSLGDLW---SFDYFRGEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRC
 .|| |||       .    | ..| .||.|| |. .. |. ..||.||.| |.. .. |  
nlsRAlGDhaYkkneeLplkeqmisAlPDikvltltee.deFlvlAcDGiWnvmesqevvdf