Gene PPM1E in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP144_AA protein Get Run
NvecP144_AA_23-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 37-297 1e-129 424.3 In-house 2-262 (265) alignment 
Range on Protein: 37-297
Range on HMM: 2-262/265.0
YTYETSVYAIKNTRRKMEDKHVIMPHFNSLFGLpKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKDPGLALHETFQNTDCSFGARAISEGL
..||.|..|.||.||||||.||.....|.||.| ||....|.|||||||||..||..||.|||..|...|.|..||  ||.|.|..||..| ..|..|.|
seyevsiaavknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaerekl

RSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVWFGAWRVNGSLSVSRAIGDAEHKPFISGEPDVAEYALDGE
.||.|||..||....||.||||||||.|...||...||.||||||.|||.||| .||.||..|||||||.|||||||||...||..|||.||||..|||.
ksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgs

QEFVILACDGLWDTVKPEQAIKLVKEHIASGN-DRCDVAKVLVDEAKQEGSSDNISVLVVFL
.|..|||||||||.|..|...|||.|..|.|. |...|||.||..||..||||||.|.||||
eeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
0034914 PP2C-like 24-297 1.6e-73 240.0 In-house 6-290 (295) alignment 
Range on Protein: 24-297
Range on HMM: 6-290/295.0
KWKEEPPTFYKSSYTYETSVYAIKNTRRKMEDKHVIMPHFNSLFGlpkdspNYAYFAVFDGHGGIDAATFAATHLHCFLAQ--------NEHLIKDPGLA
... |. . . . . .  .|. ... |...|| ........||..      ....|.||||||| .|| .|. .|. .|..        ... . |.  |
lpllellllsslllllrvgvasdqGrrksneDavlvvlnllslle......dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieea

LHETFQNTDCSFGARAIS--EGLRSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVWfgaWRVNGSLSVSRAI
|...|...|  . . |..  | ..||.||| .||... ||.|..|||.|.|...||.. |   ||| ...|. ||. .||.|..   .||||.| |.||.
lrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRal

GDAEHK---------PFISGEPDVAEYALD-GEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEGSSDNISVLVVFL
|| ..|         |..| ||||  . |. .. .|..||.|||||.. .|.....|....|.|.|  ..|. |||.| . ||.|||.|.||.|
GdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
PP2C Protein phosphatase 2C 42-290 3.1e-73 239.5 Pfam-A 4-255 (255) alignment 
Range on Protein: 42-290
Range on HMM: 4-255/255.0
SVYAIKNTRRKMEDKHVIMPHFNSLfglpKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKD--PGLALHETFQN-TDCSFGARAI-SEGLR
.. .... |..|||.|.. .....     ..  . |.||||||||| .||..|..||. .|.... . ..     || ..|.. || ..  ..  .| ..
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsk

SGCTAVSILITNEALYLAWLGDSQAILCKDGEFI-ELMQPHKPERQDEKDRIEGLGGCVVWfgAWRVNGSLSVSRAIGDAEHKP----FISGEPDVAEYA
||.|||..||... ||.|..|||.|.||...... ||.. |||...||..|||..|| | .   .||||||.||||.|| | ||    ..| |||| .  
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEGSSDNI
|. | ||.|||.||||| .....|. ||.... ....  ..|. |||||.. ||.|||
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 42-290 3.1e-73 239.5 In-house 4-255 (255) alignment 
Range on Protein: 42-290
Range on HMM: 4-255/255.0
SVYAIKNTRRKMEDKHVIMPHFNSLfglpKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKD--PGLALHETFQN-TDCSFGARAI-SEGLR
.. .... |..|||.|.. .....     ..  . |.||||||||| .||..|..||. .|.... . ..     || ..|.. || ..  ..  .| ..
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsk

SGCTAVSILITNEALYLAWLGDSQAILCKDGEFI-ELMQPHKPERQDEKDRIEGLGGCVVWfgAWRVNGSLSVSRAIGDAEHKP----FISGEPDVAEYA
||.|||..||... ||.|..|||.|.||...... ||.. |||...||..|||..|| | .   .||||||.||||.|| | ||    ..| |||| .  
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEGSSDNI
|. | ||.|||.||||| .....|. ||.... ....  ..|. |||||.. ||.|||
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 43-290 1.7e-70 230.4 In-house 5-259 (259) alignment 
Range on Protein: 43-290
Range on HMM: 5-259/259.0
VYAIKNTRRKMEDKHVIMPHFNSLfglpKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKD--PGLALHETFQN--TDCSFGARAIS-EGLR
. |... |..|||.|.. ....|      .  . |.|||||||||  ||..|..||. .|.... . ..  .  || ..|..  || ..   . . | ..
asafqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepst

SGCTAVSILITNEALYLAWLGDSQAILCKDGEFI-ELMQPHKPERQDEKDRIEGLGGCVVWFGAWRVNGSLSVSRAIGDAEHKP------FISGEPDVAE
||.|||..|||.. || |..|||.|.||..|... .| . |||...||..||||.|| | . | .||||.| ||||.|| | ||       .| |||. .
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdiss

YALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGnDRCDVAKVLVDEAKQEGSSDNI
 ..| |.||.|||.||||| | ...|. ||....... |  ..|. |||||.. ||.|||
tkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2Cc_SM00332 39-295 6.4e-68 222.1 In-house 12-274 (274) alignment 
Range on Protein: 39-295
Range on HMM: 12-274/274.0
YETsvYAIKNTRRKMEDKHVIMPHFNslfglpkDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKD-----PGLALHETFQNTDCSFGARAIS
| .   . .. |..||| ||. ....        . . ..|.||||||| ..| |.. .|. .|...    ||     .  ||.. |..||  . . . |
ygk..ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqs

EGL---RSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGcvvWFGAWRVNGSLSVSRAIGDAEHK-------PFIS
. |   .||.|||..|...| ||.|..|||.|.||..|....| . ||||..||..||.  ||   .   .||||.|.||||.|| . |       |.|.
kelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg...vvekgrvngglavsrafGdhflkknkklkepyit

GEPDVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGN--DRCDVAKVLVDEAKQE-GSSDNISVLVV
 ||||   .|. | ||.|||.||||| .........|....|.|.  |  ..|. |..|| .  ||.|||.|.||
aepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 35-297 2.3e-63 207.2 In-house 8-280 (282) alignment 
Range on Protein: 35-297
Range on HMM: 8-280/282.0
SSYTYETSVYAIKNTRRKMEDKHVIMPHFnslfglPkDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLI-----KDP----GLALHETFQNTDC
.  ..  .| . .. |..|||.|... ..      .   .. ..|||||||.| ..|.....||.  . ..|.|      ...      ||.. | ..| 
egnglrygvssmqgwrvemEDahtvvasl......g.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLalde

SFGA--RAISEGLRSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVwfgAWRVNGSLSVSRAIGDAEHKP---
.  .  .  .. ..||.|||..|.... |..| |||| |.||..|. . | . |||.|..||.|||  || ||     ||||.| ||||.|| | |    
airelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeee

------FISGEPDVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEGSSDNISVLVVFL
       .|.||.|.    . |..|..|||||.||... |....||....  ...   ||| |||.| ..|| ||.|||||..
kkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
subfamily_PPM1G2_pd Subfamily PPM1G2 38-297 8.4e-56 182.0 In-house 18-286 (287) alignment 
Range on Protein: 38-297
Range on HMM: 18-286/287.0
TYETSVYAIKNTRRKMEDKHVIMPHfnsLFGLpKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKDP-GLALHETFQNTDCSFGARAISEGL
... .  |..  |..||| |.. ..   |. . .|... |.||||||||| ..| .|...|. ..|..... ..    .|...| .|| ..      .  
ltkvgssamqGyrlnmeDahilene...llek.sddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkde

RSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVwfgAWRVNGSLSVSRAIGDAEHKP---------FISGEPD
 .|.|||..||..| || |  |||.|.|...|.   |   |||....|| ||.  || |      ||||.|..|||.|| |.|           .  .||
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtavPD

VAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEGSS------DNISVLVVFL
|    || ..||..|||||.|| .. .. ..||.|...|| .  .... |.|.. .. ||      ||..|..| |
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 46-295 1.3e-55 181.4 In-house 13-251 (255) alignment 
Range on Protein: 46-295
Range on HMM: 13-251/255.0
IKNTRRKMEDKHVImphfnslFGLPKDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKD-PGLALHETFQNTDCSFGARAisegLRSGCTAVS
.   |  |||. ||       .|  .| ..  |.|.|||||| .||.||. .|.  ||.  .| .  |  .|........  .. |.     . |.||.|
miGrrptmedelvi.......yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp....kfiGttaas

ILITNEALYLAWLGDSQAILC-KDGEFIELMQPHKPERQDEKDRIEGLGGCVVWF-GAWRVNGSLSVSRAIGDAEHKPFISGEPDVA-EYALDGEQEFVI
.||...  |.| .|||...|| |||    |   |||  ..|. ||. ||| ||    . |||| |.||||.||.  .||.  .||.  ..    ...|.|
vliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkfli

LACDGLWDTVKPEQAIKLVKEhIASGNDrcdVAKVLVDEAKQEGSSDNISVLVV
|||||.|| .  |.|...| . |.. ..    |. | | | . ||.|||||.|.
lacdGiwdlisdeeaveivag.isdpek...aaeklrdlayssGstdnisvivi
0049733 PP2C-like 40-297 6.6e-54 175.6 In-house 4-233 (235) alignment 
Range on Protein: 40-297
Range on HMM: 4-233/235.0
ETSVYAIKNT-RRKMEDKHVImphfnslfglpkdspNYAYFAVFDGHGGIDAATFAATHLHCFLAQ--NEHLIKDPGLALHETFQNTDCSFGARAIS--E
..... ...  |. .|| ...               ....|||.|||||  |. .|. .|. .|..   |.|. |.  ||...|. ..  . ..|..  |
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspe

GLRSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVvwfgawRVNGSLSVSRAIGDAEHKpfisgePDVAEYALD
  ..|.||| .|.... ||.|..||| |.|..||... | ..|.| ...|. ||. .|| |      ||.|.| ..||.|| ..|      ||| .. |.
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlele

GEQeFVILACDGLWDTVKPEQAIKLVKEhiasgNDRCDVAKVLVDEAKQEGSSDNISVLVVFL
 .  |..||.||||| . .|....|...     .|  ..|. ||..| . |. |||.|.||.|
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_ILKAP_pd Subfamily ILKAP 43-295 7.7e-46 149.6 In-house 9-290 (293) alignment 
Range on Protein: 43-295
Range on HMM: 9-290/293.0
VYAIKNTRRKMEDKHVIMPHFNSLFGLPKD-SPNYAYFAVFDGHGGIDAATFAATHLHCFLAQ----NEHLIKDP--GLALHETFQNTDCSFGARAISE-
.   |  | .|.|.|||. ....  .|.|.   . .|.||||||.|  |. ||| .||  . .    ..   |.     .| ..|..||  | . | .. 
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskak

-GLRSGCTAVSILITNEALYLAWLGDSQAILCKD---GE---FIELMQPHKPERQDEKDRIEGLGGCVvWFGawRVNGSLSVSRAIGDAEHKPF-ISGEP
   . |.||...|. .. || | ||||.|.|..    |.   .. | . |.| ...|. ||.  || | . |  ||.| | |||.||| ..|   ..  |
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdg..rvlGvlevsrsiGdgrfkrlGvistP

DVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASG-----------NDRCDV-----AKVLVDEAKQEGSSDNISVLVV
||    |.    ||.|||||||.... ....| . . . .            ... .|     .. |  || . |||||..||.|
dvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv
subfamily_PPM1L_pd Subfamily PPM1L 40-296 5.3e-43 140.2 In-house 6-265 (269) alignment 
Range on Protein: 40-296
Range on HMM: 6-265/269.0
ETSVYAIKNTRRKMEDKHVIMPHFNslfglpkDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNE---HLIK------DPGLALHETFQNTDCSFGAR
...||...  | .|||.  |  . .       .. .  .|||||||||  || ||   |   . ..    .  |      . .  | .     |  .  .
qvavysvlGrrprmedrfeieedik.......nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek

AISEGLRSGCTAVSILITNEALYLAWLGDSQAILC-KDGEFIELMQPHKPERQDEKDRIEGLGGCVVWFGAWRVNGSLSVSRAIGDAE--HKPFISGEPD
| ..   .|.||.  |.... | .| .|||. .|. |.|. | |   |||..  |. ||.  || . . |.|||.| |..|||.||    .| ..  .||
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd

VAEYALDGEQ-EFVILACDGLWDTVKPEQAIKLVKEHIASGNdrcDVAKVLVDEAKQEGSSDNISVLVVF
.  . ||  . ||.|||.||||||   |.|.. .||..   .     || || |. . || |||.|||| 
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd...fGakslvlesfkrGsvdnitvlvvk
subfamily_PPM1K_pd Subfamily PPM1K 72-296 5.5e-38 123.6 In-house 27-257 (263) alignment 
Range on Protein: 72-296
Range on HMM: 27-257/263.0
DSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKDPGLALHETFQNTDCSFGARAI-----SEGLRSGCTA-VSILITNEALYLAWLGDSQAILC
 .|.  |.||||||.|  || |. ..|.  | .  .  ||    |...|.. |  .   .      .| | || || ||.|     | || ||||.||||
ldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailc

KDGEFIELMQPHKPERQDEKDRIEGLGGCVVW--FGAWRVNGSLSVSRAIGDAEHKPF-ISGEPDVAEYAL-DGEQEFVILACDGLWDTVKPEQAIKLVK
..|.   | . |.||...||.||   || | |   |  .||| |...|..|| . |.. .  .|.  .  .  ... |..|  ||. . |. ..  .||.
rnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr

ehiaSGNDRCDVAKVLVDEAKQEGSSDNISVLVVF
      .|  . |..|.. | | || || ...|| 
....lchdpeeaahalteqalqygsednatavvvp
subfamily_PPM1D_pd Subfamily PPM1D 43-297 7.9e-37 120.0 In-house 6-307 (309) alignment 
Range on Protein: 43-297
Range on HMM: 6-307/309.0
VYAIKNTRRKMEDKHVIMPHFNSLFGlpkdSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHLIKDP-----------GLALHETFQNTDCSFGARA
. | .  |. |||  .|. . ..       . ..|..|||||||| .||.||  ||  .. ...... ..            ||.||. ...  ..  ..
seadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktk

ISEGLRSGCTAVSILITNEALYLAWLGDSQAILCKDGE------FIELMQPHKPERQDEKDRIEGLGGCVVWF-GAWR---------VNGS--------L
  .   .| ||  ..|..| ||.|  |||...| .. .        ||.. ||||  .|| ||| ||| |    |  |          ||         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

SVSRAIGD-----AEHKPF-ISGEPDVAEYALDGEQE-FVILACDGLWDTVKPEQAIKLVKEHIA----SGNDRCDVAKVLVDEAKQEGSS-----DNIS
.|.|..||     |. . | .| |||| .. ||...| |.||| ||||. ..||.|...|... .     ..   .|||.||.|| |. .|     ||.|
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvs

VLVVFL
|.||.|
vivvil
PPM_PTC7_SpoIIE 43-288 1.7e-35 115.9 In-house 5-220 (230) alignment 
Range on Protein: 43-288
Range on HMM: 5-220/230.0
VYAIKNTRRKMEDKHVIMPHFNSLfglpKDSPNYAYFAVFDGHGGIDaaTFAATHLHCFLAQNEHLIK-DPGLALHETFQN--TDCSFGaraiseGLRSG
. |... |..|||.|.. .....      .    ......|||||    ..|...|. .|. . .    .|. .|......  .|             ||
asaaqgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede......psssg

CTAVSILITNEA--LYLAWLGDSQAILCKDGEFielmqphkperqdEKDRIeGLGGCV-VWFGAWRVNGSLSVSRAIGDAEHKP---FISGEPDVAEYAL
.||| .||...   ||.|..||| ..|..|..              |. || ..|| . . .. .||.|.|.||.|.||   ..    .. |||  .  |
aTavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel

DGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGndrcdvakvlvdeAKQEGSSD
.|..||.|||.||||| . |.... ||.... .              | ... .|
fgkdeflilasdglwdvlspqelvdlvrdelekp.............aaeglleD
subfamily_PPM1G_pd Subfamily PPM1G 133-294 1.1e-34 113.2 In-house 291-467 (473) alignment 
Range on Protein: 133-294
Range on HMM: 291-467/473.0
SEGLRSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVWFGawRVNGSLSVSRAIGDAEHK---------PFIS
..|  ||.||| .|. .. |. |  ||| ..|...|. ..|   |||| . |..|||  || |   |  |||| | .|||.||   |           ||
epGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmis

GEPDVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDR--CDVAKVLVDE-----AKQEGS-SDNISVLV
  ||.   .|  |.||..|||||.|.... .. .  |..... |..    .. . |.|.      . .|.  || .|..
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtvii
subfamily_KAPP-like_pd Subfamily KAPP-like 72-296 3.2e-26 84.9 In-house 30-265 (266) alignment 
Range on Protein: 72-296
Range on HMM: 30-265/266.0
DSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQNEHL--IKDPGLALHE---TFQNTDCSFGARaISEGLRSGCTAVSILITNE----ALYLAWLGDSQA
.. | | ||||||| |  ||  |   .   | .  .    .| |   ..    ..|.  .  |. ...    |.||   |. ..     |  | .||| |
ncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdak.lkdfeyeGatatlalvwsdGqqrylqvanvGdssa

ILCKDGEFIELMQPHKPERQDEKDRIEGLGgCVVWFGAWRVNGsLSVSRAIGDAEH---KPFISGEPDVA-EYALDGEQEFVILACDGLWDTVKPEQAIK
.|..  | .|| . || . ..|| ||   |   .  .  |.|| | ||||.||         ...|| |. ...|   ..|.|.| ||||| .. ..||.
flsrGneslelskdhkakdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaie

LVKEHIASGNDRCDVAKVLVDEAKQEG-SSDNISVLVVF
 ||     ..   ..|. |.. | |   . ||.||.|| 
kvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 72-296 9.2e-23 73.5 In-house 29-275 (276) alignment 
Range on Protein: 72-296
Range on HMM: 29-275/276.0
DSPNYAYFAVFDGHGGIDAATFAAT----HLHCFLAQ-NEHLIK--DPGLALHET---FQNTDCSFGaRAISEGLRSGCTAVSILITNEA----------
.. | | ||||||| |  ||  |       |  .|   |  | |  | |   ..    ...         ...    |.||   |. ..           
ncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevd.aklkdfeyeGatatlalvwsdGeeqqqqqqry

LYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGgCVVWFGAWRVNGsLSVSRAIGDAEH---KPFISGEPDVA-EYALDGEQEFVILACDGL
|  | .||| |.|..  | .|| . || .  .||.||   |   .  .  |.|| | ||||.||         ...|| |. ...|   ..|.|.| |||
lqvanvGdssaflsrGneslelskdhkatdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGl

WDTVKPEQAIKLVKEHIASGNDRCDVAKVLVDEAKQEG-SSDNISVLVVF
|| .. ..||. ||     ..   ..|. |.. | |   . ||.||.|| 
wdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PP2D1_pd Subfamily PP2D1 146-270 4.3e-21 68.2 In-house 184-312 (492) alignment 
Range on Protein: 146-270
Range on HMM: 184-312/492.0
LITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERQDEKDRIEGLGGCVVWFGA-WRVNGSLSVSRA---IGDAEHKPFISGEPDVAEYALDGEQEFVI
|.    ||.|  |. ||.||..|. | | . | |. . |..|.|  |. ||  .   .||| |.. |    .|| . |  .  || .    || .. |..
leelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflv

LACDGLWDTVKPEQAIKLVKEHIASGNDR
||  |||. .. |. ..|||. .|  ..|
lAsnGlWevlseeevlsLvkqtlaiyksr
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 78-216 2.1e-20 66.5 In-house 22-183 (292) alignment 
Range on Protein: 78-216
Range on HMM: 22-183/292.0
Y-FAVFDGHG--GIDAATFAATHLHCFLAQNEHLIKDPGLALHETFQNTDCSFGARAISEGLRSGCTAVSILITNE-ALYLAWLGDSQAILCK-----DG
.  ||.||||  |   | .|. .|   | .  .  ..   ||     ..   .    | ...... ..|   . .. ||.|| .|||.|.| .     | 
flaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdy

EFIELMQPHKPERQDEKDRIEGLGGCVV--------WFGAWRV------NGSLSVSRAIGDA
| | | . ||||  ||. ||   || |         . |. ||      .| |..|||.|| 
eliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
Subfamily Dicty-PPM1L-like 38-297 1.1e-19 63.4 In-house 6-303 (305) alignment 
Range on Protein: 38-297
Range on HMM: 6-303/305.0
TYETSVYAIKNTRRKMEDKHvimphfNSLFGLpKDSPNYAYFAVFDGHGGIDAATFAATHLH-CF-----------LAQNEHLIKDPGLALHETFQNTDC
 ..  .|. .| |.. ||..      .   .| ..| .  .| |||||.|  || ..  .|  ..            |.|    . |  |..... .|| 
etkyelyvsansrkyqedrn......kvkisl.essqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdk

SFGARAISEGLRSGCTA----VSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPE---------------------RQDEKDRIEGLGGCVVWFGA
|. . | |.. ..| |      |. . .| .  .  .|... |.  .    |   . |                      ..... ||| |..... .| 
ssldsaesdnkkaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynyge

WRVNGSLSVSRAIGDAEHKPFISGEPDVAEYALD-GEQEFVILACDGLWDTVKPEQAIKL----VKEHIASG---NDRCDVAKVLVDEAKQEGSSDNISV
 .||. |..|| .|| . | ..  ..|   . .   . .|..|| ||||. .. .. ..     ....  ..    |  .. .| | || . || ||| .
llvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitl

LVVFL
....|
viikl
subfamily_PHLPP_pd Subfamily PHLPP 77-296 8.2e-17 53.9 In-house 28-244 (246) alignment 
Range on Protein: 77-296
Range on HMM: 28-244/246.0
AYFAVFDGhggiDAATFAATHLHCFLAQ--NEHLIKD--PGLALHETFQNTDCSFGaraiSEGLRSGCTAVSILITNEA--------LYLAWLGDSQAIL
| . .|||    |...  .. | .....  .|.. ||      .. |.  . .  |    ..| . | .|. ||| ..         | .|  |  ||.|
alyGlfdG....drneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklG....eaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavl

CKDGEFIELMQPHKPERQdEKDRIEGLGGCVVwfGAWRVNGSLSVSRAIGDAEHKPFISGEPDVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHi
...|. . | .... |.. | .||    . .      ..|| .. .| .|     |..  .| | |  |  ..|..|.  . ||...  ..| . |... 
iRngkklrlsksyviekd.elkrikeakaiit..ednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrke.

asgNDRCDVAKVLVDEAKQEGSSDNISVLVVF
   .|   .|| ||| |.  | .|..||||| 
...edplvaAkklvdlaqsygaadsvsvlvvr
PPM_PTC7_motif 241-290 2.4e-15 49.8 In-house 1-51 (51) alignment 
Range on Protein: 241-290
Range on HMM: 1-51/51.0
ILACDGLWDTVKPEQAIKLVKEHIASGND-RCDVAKVLVDEAKQEGSSDNI
|||.||||| .....|. ||...... ..    .|. ||||| ..||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_SIG_SM00331 72-296 6.7e-14 45.0 In-house 26-216 (217) alignment 
Range on Protein: 72-296
Range on HMM: 26-216/217.0
DSPNYAYFAVFDGHG-GIDAATFAATHLHCFLAQNEHLikdpgLALHETFQNTDCSFGARaiSEGLRSGCTAVSILI--TNEALYLAWLGDSQAILCKDG
..  .  ..|.||.| |..|| ...  .. .  . ..       .| .......  . ..  .|  ....|.. .|.  ..  |..| .|||  .|  ||
lnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllrdg

EFIELMQPhkperqdekdrieglggcvvwfgawrvngslSVSRAIGDAEHKPfisgePDVAEYALDGeQEFVILACDGLWDTVKPE-----QAIKLVKEH
. .|  .                                  ....|  .. .     .|..|  |.   ....|. |||.. ....     . .......
klveilkd...............................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerleeiledl

IasGNDRCDVAK----VLVDEAKQEGSSDNISVLVVF
   ..   ..|.     |. .||... .|.|.|.||.
v..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PDP_pd Subfamily PDP 220-276 1e-13 44.2 In-house 268-324 (398) alignment 
Range on Protein: 220-276
Range on HMM: 268-324/398.0
PFISGEPDVAEYALDGEQEFVILACDGLWDTVKPEQAIKLVKEHIASGNDRCDVAKV
|... ||.| .. |  .. |..|| |||||....|....||.||.|. ... .|.  
PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkve
subfamily_TAB1_pd Subfamily TAB1 131-219 6.8e-13 41.1 In-house 122-213 (333) alignment 
Range on Protein: 131-219
Range on HMM: 122-213/333.0
AISEGLRSGCTAVSILITNEALYLAWLGDSQAILCK---DGEFIELMQPHKPERQDEKDRIEGLGGCVVWFGAWRVNGSLSVSRAIGDAEHK
 . | .. | ||| .|| |. || |  |||.|.|.|     ..  | . |. . .||  |...||  .      .. ||    |.||| . |
eleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvk
subfamily_PPM1H_pd Subfamily PPM1H 115-188 6.1e-11 34.7 In-house 139-210 (404) alignment 
Range on Protein: 115-188
Range on HMM: 139-210/404.0
ALHETFQNTDCSFGARAISEGLRSGCTAVSILITNEALYLAWLGDSQAILCKDGEFIELMQPHKPERqdEKDRI
|| . |.. |        .  .. ||||.. |. .. ||.|  |||.|||.. .| |.| . . ||   |. |.
alesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRl
PPM_PTC7_SpoIIE_motif 238-295 3.4e-09 30.2 In-house 13-78 (81) alignment 
Range on Protein: 238-295
Range on HMM: 13-78/81.0
EFVILACDGLW-------DTVKPEQAIKLVKEHiaSGNDRCDVAKVLVDEAKQEG---SSDNISVLVV
. ..|..|||.       ... .|....|....  .|..  ..|. ||||... |   ..|.|..||.
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvl
subfamily_PPM1G_pd Subfamily PPM1G 43-127 6.9e-09 28.2 In-house 23-99 (473) alignment 
Range on Protein: 43-127
Range on HMM: 23-99/473.0
VYAIKNTRRKMEDKHVIMPHFNSlfglpkdspNYAYFAVFDGHGGIDAATFAATHLHCFLAQNE-HLIKDPGLALHETFQNTDCSF
. | .  | ..|| |  .. ...         . . |||.||||| . |.. |..|  .| ... .   |   ||.|.| . | . 
asamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl
subfamily_PPM1H_pd Subfamily PPM1H 215-282 1.1e-08 27.2 In-house 289-374 (404) alignment 
Range on Protein: 215-282
Range on HMM: 289-374/404.0
D---------AEHKPFISGEPDVAEYALD----GEQEFVILACDGLWDTVKPEQAIKLVKEHIASGN--DR---CDVAKVLVDEAK
|          . |||.| .|.|  . |.     | . .||| ||||| .. |.. ..|.| ... .  |.     ||. || .|.
DheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqeLvaaar
subfamily_PP2D1_pd Subfamily PP2D1 47-104 1.4e-07 23.6 In-house 9-61 (492) alignment 
Range on Protein: 47-104
Range on HMM: 9-61/492.0
KNTRRK--MEDKHVIMPHFNslfglpkDSPNYAYFAVFDGHGGIDAATFAATHLHCFLAQ
||.| |  ||||.... .|        . .| ..|...||. |  ||  ||..||  |..
knsrWKskmeDkrtlqdyfg.......ndvnscFfgiyDGynGataAeiaakelhevlle
subfamily_PPM1H_pd Subfamily PPM1H 75-104 3.8e-06 18.9 In-house 61-90 (404) alignment 
Range on Protein: 75-104
Range on HMM: 61-90/404.0
NYAYFAVFDGHGGIDAATFAATHLHCFLAQ
..|||..||||.|  ||. |.  ||  | .
playfglfDGhaGsgaalvaskllhkhlke
subfamily_PDP_pd Subfamily PDP 137-219 8.3e-06 18.1 In-house 151-241 (398) alignment 
Range on Protein: 137-219
Range on HMM: 151-241/398.0
RSGCTAVSILITNEALYLAWLGDSQAILCKD---G--EFIELMQPHKPERQDEKDRIEGLG-----GCVVWFGawRVNGSLSVSRAIGDAEHK
 || .|.  || .. |..|  ||..|.|..    |  | ..| . .  . ..|  ||.          |.  |  |. |.|  .|| ||...|
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirng..RlLgeLqPlRAFGdvryK