Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1G_pd | Subfamily PPM1G | 4-458 | 2.2e-202 | 666.2 | In-house | 1-472 (473) | alignment | ||
Range on Protein: 4-458
Range on HMM: 1-472/473.0
YLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESIV
||||||.|..|..|||...|||||||||||||.||||.|..|.|||||||||||||||.|||.||.|.|||.|. . |||||....|| ..||..||...
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk
SEEGLKELKEIAG--DNDDS------GDENEADLLTKDANIPLSELLAKLKENNLELKDVYVIALQRANENEEDSGEDSEEEEENGHLMNGDSKTEEKKN
.|| ||||||||. ...|. ||.|..|||..|.|||.|||..|.... | .......|..|....|......|||||. . ....||.||||.
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrldgdgsekeelsqallegaasedeedededeeeeeeekdteeeskeeekka
ANGKMGQKERHSEDEEEKENKDDSKSADKDDDKGVDEKGVDEEGASEEPQDGEEEEEEEEESEEEEEEEEDEDGEGVLV--------KSDEVGYDSGTTA
...|.|..|...|||.|||.....|.....|.||..|....|....|| .|.||.||||||..||.||||.|||||... ...|.|.||||||
kaakegkqekkeedesekeeeeeekeeeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttA
IVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE
.|||.|...|.|||.|||||||.||| |||.|.|||||||.||.||.||||||...||||||||||||||||.|| ..||...||.|.|.|||...||||
vvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlte
ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN-LSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSFKP
.|||.|.||||||||..||||||||....|.|||. ||.|.|.|.||||||||||||.||||||..||..|.
edeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
|
|||||||||
PP2Cc_SM00332 | 14-454 | 3.6e-88 | 288.5 | In-house | 2-274 (274) | alignment | |||
Range on Protein: 14-454
Range on HMM: 2-274/274.0
SVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFD--EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG----NTKQALIDTFLKVDESIVSEEG
|...||...||| |.|||||.|||||| . .|.. ||...|.|.|||||.|||..|||.||. | . .|.. ....|| . ||..|| |. ||
sesgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq
LKELKEiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdskteekknangkmgqkerhs
|||..
skelen..............................................................................................
edeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdevgYDSGTTAIVALVKDNNLTVANVGDSRC
.||.||.|||.|...| ||||||||.
.........................................................................alsGstavvallkkedlyvanvGDSra
VLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEgRVNGGLNLSRALGDHSYKGQSelGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQE
|||||| |...| |||||||.|..||.||||.| . ||||||..|||.||| .| .. . |. ||| ||. ..|||..|||...|.||.|.| ..||
vlcrngkavqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqe
VVDFVKQEMKNGEENLSSICEKLFDACLAPDtsgdGAGCDNMTCVIV
|||.|.. ...|..| . ...| |...... | ..||.|.|.|
vvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvvv
|
|||||||||
0034914 | PP2C-like | 3-457 | 4.5e-81 | 264.7 | In-house | 2-291 (295) | alignment | ||
Range on Protein: 3-457
Range on HMM: 2-291/295.0
AYLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDF---DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRG-------DIGYKEGNTKQALI
..||.|..|. ... .. ....|.. .||.| |.|||....|.. .||..||.|.||||| ..||..|..|.. |. . . . ..||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr
DTFLKVDESIVSEEGLKelkeiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdsktee
..||..|| .... |.
kaflaadeellelallr...................................................................................
kknangkmgqkerhsedeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdEVGYDSGTTAIVALV
. |||||.|||.
.....................................................................................pelagsGtTavvali
KDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLT-EADEF
..| |.||||||||.||.||| .. ...|||| .| | || .||| |. |||||.|...|||||...| . | ..|. ..|.||.....|| | |.|
rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddf
MVIACDGIWNVKNSQEVVDFVKQEMKnGEENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
...|.||.|.| ...|.||.|.. .. . .|. ..|.| |..|| . ..||.|.|.| ..
llLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla......rgsrDNiTvvvvrln
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 282-456 | 1e-67 | 221.1 | In-house | 114-286 (287) | alignment | ||
Range on Protein: 282-456
Range on HMM: 114-286/287.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIR
..|.||.|.|.|...| |||.||||.||. .| . .|.||||..|.| .|| .||| | .|||| | |||||||...| .......||..||.||.
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvel.nrvngnLalsralgDfefkknvkkkpeeqivtavPDvl
QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSF
. |.| |||.|.||||||.| ...||||.|......| .|..|.|.|.| |||||.| | ||||||.|||..
vkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
PP2C | Protein phosphatase 2C | 281-440 | 3.3e-58 | 190.3 | Pfam-A | 98-252 (255) | alignment | ||
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
.||.||.|||.....| ||||||||.||||.. | .. ||||.||.| .|| .|||.| .||||| |..||||||. .| .. ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd
IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
|
|||||||||
PP2C | Protein phosphatase 2C | 281-440 | 3.3e-58 | 190.3 | In-house | 98-252 (255) | alignment | ||
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
.||.||.|||.....| ||||||||.||||.. | .. ||||.||.| .|| .|||.| .||||| |..||||||. .| .. ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd
IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
|
|||||||||
PPM_PTC7 | 281-440 | 1.7e-57 | 187.8 | In-house | 99-256 (259) | alignment | |||
Range on Protein: 281-440
Range on HMM: 99-256/259.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVT--CEGRVNGGLNLSRALGDHSYKGQSElgaHEQQITAM
.||.||.|||. ...| ||||||||.||||.| | .. ||||..|.| .|| .|||.| .||||| |..|||.||. .| . .||...|
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae
PDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeeNLSSICEKLFDACLAPDTS
||| .|...| |||...|.||.|.| ..||.||.|..|.. . .. ..||| | ..|....
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargse
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 248-457 | 2.4e-57 | 187.4 | In-house | 115-281 (282) | alignment | ||
Range on Protein: 248-457
Range on HMM: 115-281/282.0
EeeeeeeeeseeeeeeeededgegvlvksdevgydsGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVN
|.||...||....| .||.|||| |||||| | .. ||||...|| .||..|||.|. .|||
s...................................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvn
GGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSgdgagcD
| | .||||||..|| ..|..|.||...| |... . .| |.|.|.|||||| | ...|||..|..... . ..|......| | .| .. |
GaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsr......D
NMTCVIVSFK
|.....| |.
Nlsvlvvlfa
|
|||||||||
0049733 | PP2C-like | 280-457 | 9.1e-42 | 136.0 | In-house | 89-234 (235) | alignment | ||
Range on Protein: 280-457
Range on HMM: 89-234/235.0
GYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVtcegRVNGGLNLSRALGDHSYKgqselgaheqqitamPD
. .||||.|||. .. |.||||||||..|.|.| .. .. ||.| .| | ||..||| | ||.|.| |.|||||. .| ||
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............pd
IRQTTLTEADeFMVIACDGIWNVKNSQEVVDFVKQemkngeENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
.....|.. | |...|.||.|.| ...|.||.... .|. ..|.|....|| . |.||.|.|.| ..
vtvlelepgd.flllasDGlwdvlsdeeivdllrs......ldleeaaerlvelala......rggrDNiTvvvvrld
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 270-458 | 2e-40 | 131.7 | In-house | 89-264 (265) | alignment | ||
Range on Protein: 270-458
Range on HMM: 89-264/265.0
EGVLVKSDEVGYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKgqsel
| .| |. . .. ||.||.|.|.. ..| || .|||. .|.|.| |. . ||||.|.| .|| .||| | | |||| |..|||.|| ..|
erflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.....
gaheQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLFDACLAPDTSgdgagcDNMTCVIVSFKP
. ... .|. ...|....|....||||.|.| | .|||. |.. ...|.|.||.. ..| .| . | ||.| |.| ..|
....pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfldp
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 278-455 | 7.5e-35 | 113.4 | In-house | 90-252 (255) | alignment | ||
Range on Protein: 278-455
Range on HMM: 90-252/255.0
EVGYDSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE---GRVNGGLNLSRALGDhSYkgqseLgahEQQ
| . ||||...|. .. .||||||| ||| ..|.| .|.|||| .|.| .||...||.| . |||| | .|||||| |. | |
erpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.sf.....l...ePf
ITAMPDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEmKNGEEnlssICEKLFDACLApdtSGdgaGCDNMTCVIVS
... ||. . . .. |.|...||||||.. .| |. | . .. |. .||| | || ||.. ...
vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi.sdpek....aaeklrdlays...sG...stdnisvivik
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 281-421 | 3.4e-34 | 111.3 | In-house | 111-248 (293) | alignment | ||
Range on Protein: 281-421
Range on HMM: 111-248/293.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNG------IALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVNGGLNLSRALGDHSYKGqseLGaheqqI
. |.||.| || || | |||.|||..||.|. ... .. ||.| ...| .||.||||.|. .|||.| |. ||..|| .|. || .
WkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkr...lG.....v
TAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEE
.. ||... .||| | |.|.||||.|.| . .|||.|. . ... |.
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeed
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 282-431 | 4e-33 | 107.8 | In-house | 105-251 (269) | alignment | ||
Range on Protein: 282-431
Range on HMM: 105-251/269.0
DSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKGQselgaheQQITAMP
.||||..|||....|.|||||||| ||. ..|.|. .| ||||.. || ||.|||| .. .| ||.| | ||||||. | . . . | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadp
DIRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLF
|| | . ||...|.||.|. .| | |.|...|. . |. . |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesf
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 276-430 | 8.5e-32 | 103.3 | In-house | 91-242 (263) | alignment | ||
Range on Protein: 276-430
Range on HMM: 91-242/263.0
SDEVGYDSGTTAIVALVKD-NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE----GRVNGGLNLSRALGDHSYKgqselgah
... ||||| |.|..| ..| .|..|||| .||||| | ...||.|| |.| .||..|||.|. . .||| | ..|.||| |
aeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk........
EQQITAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQeMKNGEENLSSICEKL
. . | |. .. . .|| |.|. ||| .| ||||. |.|.. .. || ....|.
ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl.chdpeeaahalteqa
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 5-110 | 1e-28 | 93.1 | In-house | 2-112 (287) | alignment | ||
Range on Protein: 5-110
Range on HMM: 2-112/287.0
LSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTC---LLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVD
||.| .. .| . .|... |.|||||.|..|||||. ||. .. ...||||.|||||..||.|..|.| .. .|||. .|.|.|.||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD
ESIVSEEGLKE
|.....| ||.
eellkdeklkd
|
|||||||||
PPM_PTC7_SpoIIE | 279-435 | 1.6e-28 | 93.1 | In-house | 85-222 (230) | alignment | |||
Range on Protein: 279-435
Range on HMM: 85-222/230.0
VGY--DSGTTAIVALVKDNN--LTVANVGDSRCVLCRN-GIaldmsidhkpedekELNRIhKAGGKVT---CEGRVNGGLNLSRALGDHSYKGqselgaH
. .||.||.|||. .. |.|||.|||...|.|. | | || .||| . .|||.| |..|.| || ..
edepsssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......t
EQQITAMPDiRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeenlssICEKLFDACL
.. ..| || ...... |||...|.||.|.|...||.||.|..|.. ..|.| . ..
DGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDi
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 283-422 | 4e-25 | 81.7 | In-house | 152-318 (398) | alignment | ||
Range on Protein: 283-422
Range on HMM: 152-318/398.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRN---G--IALDMSIDHKPEDEKELNRIHKAGG---K--VTCEGRVNGGLNLSRALGDHSYKGQSELGAH--
||..|..||.....| |||.||.|.||... | | .|.|. . |.|..||.|. . | .||. | | .|| || || ..|| .
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl
EQ---------------QITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN
|. .|| |.. . |.|.| |.|.| ||.|.. ...|||. |.. ... .|.
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 283-434 | 8e-24 | 77.1 | In-house | 100-249 (266) | alignment | ||
Range on Protein: 283-434
Range on HMM: 100-249/266.0
SGTTAIVALVK----DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAM
|.|| .||| | ||||||| |.| .| .| ||| .|..| ||.. | .. . |.| || .||||||| | . ..| ...
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lise
PDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
| . . .|| |.|...| ||.|.| . .. .. || . .. |....| |...
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 282-418 | 1.2e-23 | 76.6 | In-house | 175-308 (492) | alignment | ||
Range on Protein: 282-418
Range on HMM: 175-308/492.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKV---TCEGRVNGGLNLSRALGDHsykGQSELgahEQQITAMP
.. . | |.. | .||.|. . ||||.| | . .| |...|| .|..|||. | |.||| |. | || . |. .| .. . |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP
DIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
.. ..|.||. |.|.| |.|.| . .||. ||| ..
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlai
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 292-434 | 4.8e-22 | 71.1 | In-house | 113-259 (276) | alignment | ||
Range on Protein: 292-434
Range on HMM: 113-259/276.0
VKD----------NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAMPDI
| | ||||||| |.| .| .| ||| .| .| .||.. | .. . |.| || .||||||| | . ..| ... | .
vwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lisepyv
R-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
. .|| |.|...| ||.|.| . .. .. || . .. |....| |...
snrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 16-105 | 2.1e-21 | 69.5 | In-house | 6-105 (282) | alignment | ||
Range on Protein: 16-105
Range on HMM: 6-105/282.0
TESNSKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGY--------KEGNTKQALIDTFLKVDESIVSE
.... .. || |.||||||.||||||. .. . | |.|||.|||.|.|||.||.|||.. . .. . .. ..|.|| . ||..||.| ..
qaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 283-415 | 7.9e-19 | 60.6 | In-house | 129-270 (333) | alignment | ||
Range on Protein: 283-415
Range on HMM: 129-270/333.0
SGTTAIVALVKDNNLTVANVGDSRCVLCR---NGIALDMSIDHKPEDEKELNRIHKAGG---KVTCEGRVnGGLNLSRALGDHSYKGQ----SEL-GAHE
||||.|||. |.| |||||||| .|.. . .| ||. . |.|| |... | .. .|. |. . |..||.. |. | |..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg
QQITAMPDIRQT-TLTEADEFMVIACDGIwnVKNSQEVVDFVKQE
. . | ||| . .... |.|. ||. .|. .|| . . .
ePviaePdiqgaypiddityflvlmSdGv..yktLeevtgpetsn
|
|||||||||
PPM_PTC7 | 23-104 | 9.6e-18 | 57.5 | In-house | 2-91 (259) | alignment | |||
Range on Protein: 23-104
Range on HMM: 2-91/259.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK--VDESIVS
.||||.||.|.||||||..| .. ... ..|||.|||||.|.|.|...||...| . .|. ....||...||. ||.. |
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 280-360 | 1.8e-17 | 56.8 | In-house | 82-184 (292) | alignment | ||
Range on Protein: 280-360
Range on HMM: 82-184/292.0
GYDSGTTAIVALVKDN-NLTVANVGDSRCVLCR-----NGIALDMSIDHKPEDEKELNRIHKAGGKVT----------CEGRV------NGGLNLSRALG
. ..|... | |.|. .| .|||||||..| | . .| |||||| | .|| .|||.|. || .|.| ||||||
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG
DHS
|
dfh
|
|||||||||
PP2C | Protein phosphatase 2C | 23-104 | 6.7e-17 | 54.9 | Pfam-A | 2-90 (255) | alignment | ||
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
.|||..||.| ||||||..| .. ... ..|||.|||||.|.|.| ..||...| . .|. . ..||...||. ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
|
|||||||||
PP2C | Protein phosphatase 2C | 23-104 | 6.7e-17 | 54.9 | In-house | 2-90 (255) | alignment | ||
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
.|||..||.| ||||||..| .. ... ..|||.|||||.|.|.| ..||...| . .|. . ..||...||. ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
|
|||||||||
PPM_PTC7_motif | 393-440 | 1.9e-15 | 50.1 | In-house | 1-48 (51) | alignment | |||
Range on Protein: 393-440
Range on HMM: 1-48/51.0
VIACDGIWNVKNSQEVVDFVKQEMK-NGEeNLSSICEKLFDACLAPDTS
..|.||.|.| ..||.||.|..... .|. . ...||| | .||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAeklvdealargse
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 294-415 | 2.3e-15 | 49.2 | In-house | 104-215 (246) | alignment | ||
Range on Protein: 294-415
Range on HMM: 104-215/246.0
DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEkELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSykgqselgAHeQQITAMPDIRQTTLTEADEFMV
.|.||.|| ||.||| | .| .. |.. ||.||..| . .| ....|| .. .| || . . . | .|...||| ||...
sfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf........lf.PvvlPkphvrevlLteqdelli
IACDGIWNVKNSQEVVDFVKQE
. . .|.| . .|.|. |..|
vGnkalWevlsideaveavrke
|
|||||||||
0049733 | PP2C-like | 21-104 | 7.5e-15 | 48.2 | In-house | 2-81 (235) | alignment | ||
Range on Protein: 21-104
Range on HMM: 2-81/235.0
KMSYGASAMQGW-RVSMEDAHTClldfdeDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGD-IGYKEGNTKQALIDTFLKVDESIVS
..|.||. ..|. | .|||. . ...||||.||||| ...|..|..|...|. .. . ....||...||...| ...
rlsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle
|
|||||||||
PP2C_SIG_SM00331 | 278-455 | 2.7e-13 | 43.0 | In-house | 81-216 (217) | alignment | |||
Range on Protein: 278-455
Range on HMM: 81-216/217.0
EVGYDSGTTAIVALV--KDNNLTVANVGDSRCVLCRNGI-ALDMSIdhkpedekelnrihkaggkvtcegrvngglNLSRALG-DHS-Ykgqselgaheq
.. ....|...||. ....| .||.||||..| |.| . . .....|| .
keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs...........
qitamPDIRQTTLTEaDEFMVIACDGIWNVKNS-----QEVVDFVKQEMKNGEENLSS-ICEKLFDACLAPDTsgdgagCDNMTCVIVS
.|||...| . ....... ||....... ... ..... ... . |.. | |.|. . .. . |..| |.|
.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvvk
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 283-343 | 1.3e-12 | 40.4 | In-house | 108-174 (309) | alignment | ||
Range on Protein: 283-343
Range on HMM: 108-174/309.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRNGI------ALDMSIDHKPEDEKELNRIHKAGGKVTCE
.|||| | ......| ||.||||. || . | . |||||. .| .||...||.|. .
aGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 24-105 | 2e-12 | 39.9 | In-house | 6-94 (265) | alignment | ||
Range on Protein: 24-105
Range on HMM: 6-94/265.0
YGASAMQGWRVSMEDAHTCLLDF----D----EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTkQALIDTFLKVDESIVSE
. |... | ||| | .| |. . .... |||.|||||.| |.| ..||. .| . || . .|| ..| ..||....
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk
|
|||||||||
PPM_PTC7_SpoIIE | 24-105 | 2.3e-12 | 40.2 | In-house | 3-87 (230) | alignment | |||
Range on Protein: 24-105
Range on HMM: 3-87/230.0
YGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEvaEYVSKHLPDVLRGDIgYKEGN-TKQALIDTFLKVDESIVSE
.||||.||.| ||||||... .. . .....|||||.. .....| ..|| . ..... ...|....|... . .|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 281-329 | 9.8e-11 | 34.0 | In-house | 160-208 (404) | alignment | ||
Range on Protein: 281-329
Range on HMM: 160-208/404.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKE
| ||.|||| .. | ||| |||| .|.|.. ..| |. || |..
ikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 350-457 | 1.7e-10 | 33.5 | In-house | 201-308 (309) | alignment | ||
Range on Protein: 350-457
Range on HMM: 201-308/309.0
LNLSRALGD-HSYKGQSElgahEQQITAMPDIRQTTLTEADE-FMVIACDGIWNVKNSQEVVDFVKQEMKNG---EENLSSICEKLFDACLApDTSGDGA
|...|.||| ||. .|. | . ||. ..||. ..| |...| ||.||| .....|..|..| . . ||. .|. ..| . | ..
LavaRslGDlWsynaksg....efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskkl
GCDNMTCVIVSFK
.||.. ..| ..
raDnvsvivvile
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 20-102 | 2.3e-10 | 33.2 | In-house | 4-88 (255) | alignment | ||
Range on Protein: 20-102
Range on HMM: 4-88/255.0
SKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESI
|.. | | | | | .||| . | . | ..|..|||||.. |.. |..|. .|. . .. | ...| ... ... |
srfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 24-105 | 2.4e-10 | 33.0 | In-house | 6-85 (263) | alignment | ||
Range on Protein: 24-105
Range on HMM: 6-85/263.0
YGASAMQGWRVSMEDaHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIgYKEGNTKQALIDTFLKVDESIVSE
| ...| | || .|...|.. .||.|||.|. |..| ..| .|. || . .. | ..|...|. . .
vGkdsliGkraened.riklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkry
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 24-100 | 3.4e-10 | 32.5 | In-house | 4-88 (309) | alignment | ||
Range on Protein: 24-100
Range on HMM: 4-88/309.0
YGASAMQGWRVSMEDAHTCLLDFDE-----DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGN---TKQALIDTFLKVDE
..| || | ||| . |. .| . . .||.|||||.| |.....|| |.. . .. . .|. ..||.. |
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflathe
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 25-103 | 7.5e-10 | 31.5 | In-house | 8-96 (269) | alignment | ||
Range on Protein: 25-103
Range on HMM: 8-96/269.0
GASAMQGWRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQA--------LIDTFLKVDESIV
. ...| | ||| . | ...| |.|||.|||||. ||.. . |.. .. . . . ... | | | ||| ..
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekll
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 345-420 | 1.4e-09 | 30.2 | In-house | 276-355 (404) | alignment | ||
Range on Protein: 345-420
Range on HMM: 276-355/404.0
RVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE----ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGE
|. . . .| ||||. | .. ....|..|.. ||. |. ...| ||.|.| . .|| |.. ... |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 273-341 | 3.6e-09 | 28.9 | In-house | 205-273 (305) | alignment | ||
Range on Protein: 273-341
Range on HMM: 205-273/305.0
LVKSDEVGyDSGTTAIVALVKDNNL-TVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVT
| || ..| | ... .|. .|..| ||. .|.. ||...|.. .| ....|. ||| |... ..|.
lkksrskG.dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkie
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 28-104 | 4.6e-09 | 28.8 | In-house | 11-102 (293) | alignment | ||
Range on Protein: 28-104
Range on HMM: 11-102/293.0
AMQGWRVSMEDAHTCLLDFDED----------TSLFAVYDGHGGQEVAEYVSKHLPDVL-----RGDIGYKEGNTKQALIDTFLKVDESIVS
.| | |.|||. | |.||. | .||.|||.|. .|.....| .. ..|. || . |..|.|.| |.|| ..
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLk
|
|||||||||
PPM_PTC7_SpoIIE_motif | 387-456 | 5.9e-08 | 26.3 | In-house | 10-80 (81) | alignment | |||
Range on Protein: 387-456
Range on HMM: 10-80/81.0
EADEFMVIACDGIW-------NVKNSQEVVDFVKQEmkNG-EenLSSICEKLFDACLApdtSGDGAGCDNMTCVIVSF
.... .....||.. .... .|........ | . | ....||.|..|. |.| |..| ... .
kpgdvllLyTDGltEardsdgelfgkeellrladra..egks..lqeladklvdevle...ngsgereDDitllvlrv
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 32-78 | 1.4e-07 | 23.6 | In-house | 13-61 (492) | alignment | ||
Range on Protein: 32-78
Range on HMM: 13-61/492.0
WRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRG
|. .|||..| .| .|. . |..|||. |. || .|.|..||
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlle
|
|||||||||
subfamily_Choan-PPM-1_pd | Subfamily Choan-PPM-1 | 281-443 | 3.6e-07 | 21.7 | In-house | 132-308 (317) | alignment | ||
Range on Protein: 281-443
Range on HMM: 132-308/317.0
YDSGTTAIVALVKDNN-LTVANVGD--SRCVL-------CRNGIALD-MSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGA
| ||||.||.| |. ..||| || . .| |.|. .. .|. |. . ..| .|.... .. . . | || .. . ||
ldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGh
HE---QQITAMPDIRQTTLTEADEFMVIAC-DGIWNVKNSQEVVDFVKQEMkNGEENLSSICEKLFDACLAPDTSGDG
. ..| |..| .| . | |... ||| . . ..|.| | . | .|. | .|. ... |
kllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraa.taleasevlcddaqdylldetsidda
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 332-418 | 4.9e-07 | 21.9 | In-house | 185-265 (305) | alignment | ||
Range on Protein: 332-418
Range on HMM: 185-265/305.0
RIHKAGGKVTCEGR--VNGGLNLSRALGDhsyKGQSELGAheqqitAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
|| ... . |. ||. |. || || |. || . .| . |.|.|.| ||.|.| . |.||..||. ...
rieslqaalynygellvnrllkksrskGd...knlkelvi......PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrd
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 277-421 | 1.2e-06 | 21.0 | Pfam-A | 91-200 (212) | alignment | ||
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.| | .|| ..|....... ....||... | |.| . ...... | . |.... .. ....
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................
itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
.||. . .|. . .. ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 277-421 | 1.2e-06 | 21.0 | In-house | 91-200 (212) | alignment | ||
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.| | .|| ..|....... ....||... | |.| . ...... | . |.... .. ....
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................
itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
.||. . .|. . .. ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 23-76 | 2.2e-06 | 19.7 | In-house | 8-63 (305) | alignment | ||
Range on Protein: 23-76
Range on HMM: 8-63/305.0
SYGASAMQGWRVSMEDAHTCLLD--FDEDTSLFAVYDGHGGQEVAEYVSKHLPDVL
|. . .. | || . . ... ||| |.|||.|. |||| |.| ...
kyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveiv
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 36-74 | 7.2e-06 | 18.3 | In-house | 11-49 (398) | alignment | ||
Range on Protein: 36-74
Range on HMM: 11-49/398.0
MEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPD
.|| .. ... ||.| |||||. || |||.|..
iEDrrseakllesngvlfgvfDGHggaacaeavskrLlk
|