Gene PPM1G in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP145_AA protein Get Run
NvecP145_AA_2-457 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-458 2.2e-202 666.2 In-house 1-472 (473) alignment
Range on Protein: 4-458
Range on HMM: 1-472/473.0
YLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESIV
||||||.|..|..|||...|||||||||||||.||||.|..|.|||||||||||||||.|||.||.|.|||.|. . |||||....|| ..||..||...
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

SEEGLKELKEIAG--DNDDS------GDENEADLLTKDANIPLSELLAKLKENNLELKDVYVIALQRANENEEDSGEDSEEEEENGHLMNGDSKTEEKKN
.|| ||||||||.  ...|.       ||.|..|||..|.|||.|||..|.... | .......|..|....|......|||||. . ....||.||||.
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrldgdgsekeelsqallegaasedeedededeeeeeeekdteeeskeeekka

ANGKMGQKERHSEDEEEKENKDDSKSADKDDDKGVDEKGVDEEGASEEPQDGEEEEEEEEESEEEEEEEEDEDGEGVLV--------KSDEVGYDSGTTA
...|.|..|...|||.|||.....|.....|.||..|....|....|| .|.||.||||||..||.||||.|||||...        ...|.|.||||||
kaakegkqekkeedesekeeeeeekeeeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttA

IVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE
.|||.|...|.|||.|||||||.||| |||.|.|||||||.||.||.||||||...||||||||||||||||.|| ..||...||.|.|.|||...||||
vvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlte

ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN-LSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSFKP
.|||.|.||||||||..||||||||....|.|||. ||.|.|.|.||||||||||||.||||||..||..|.
edeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk

PP2Cc_SM00332 14-454 3.6e-88 288.5 In-house 2-274 (274) alignment
Range on Protein: 14-454
Range on HMM: 2-274/274.0
SVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFD--EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG----NTKQALIDTFLKVDESIVSEEG
|...||...||| |.|||||.|||||| . .|..  ||...|.|.|||||.|||..|||.||. |   . .|..    ....|| . ||..|| |. || 
sesgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

LKELKEiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdskteekknangkmgqkerhs
 |||..                                                                                              
skelen..............................................................................................

edeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdevgYDSGTTAIVALVKDNNLTVANVGDSRC
                                                                          .||.||.|||.|...| ||||||||.
.........................................................................alsGstavvallkkedlyvanvGDSra

VLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEgRVNGGLNLSRALGDHSYKGQSelGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQE
|||||| |...| |||||||.|..||.||||.|  . ||||||..|||.||| .| ..  .  |. ||| ||. ..|||..|||...|.||.|.| ..||
vlcrngkavqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqe

VVDFVKQEMKNGEENLSSICEKLFDACLAPDtsgdGAGCDNMTCVIV
|||.|.. ...|..|  . ...| |......    | ..||.|.|.|
vvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvvv

0034914 PP2C-like 3-457 4.5e-81 264.7 In-house 2-291 (295) alignment
Range on Protein: 3-457
Range on HMM: 2-291/295.0
AYLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDF---DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRG-------DIGYKEGNTKQALI
..||.|..|. ... .. ....|.. .||.| |.|||....|..   .||..||.|.||||| ..||..|..|.. |.           . . . ..||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

DTFLKVDESIVSEEGLKelkeiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdsktee
..||..|| ....  |.                                                                                   
kaflaadeellelallr...................................................................................

kknangkmgqkerhsedeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdEVGYDSGTTAIVALV
                                                                                        . |||||.|||.
.....................................................................................pelagsGtTavvali

KDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLT-EADEF
..| |.||||||||.||.||| .. ...|||| .| |  || .||| |.  |||||.|...|||||...| .  | ..|. ..|.||.....|| | |.|
rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddf

MVIACDGIWNVKNSQEVVDFVKQEMKnGEENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
...|.||.|.| ...|.||.|.. .. .  .|. ..|.| |..||      . ..||.|.|.| ..
llLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla......rgsrDNiTvvvvrln

subfamily_PPM1G2_pd Subfamily PPM1G2 282-456 1e-67 221.1 In-house 114-286 (287) alignment
Range on Protein: 282-456
Range on HMM: 114-286/287.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIR
..|.||.|.|.|...| |||.||||.||. .| .  .|.||||..|.| .|| .||| |   .|||| | |||||||...| .......||..||.||. 
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvel.nrvngnLalsralgDfefkknvkkkpeeqivtavPDvl

QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSF
 . |.| |||.|.||||||.| ...||||.|......|  .|..|.|.|.| |||||.|  | ||||||.|||..
vkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvl

PP2C Protein phosphatase 2C 281-440 3.3e-58 190.3 Pfam-A 98-252 (255) alignment
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
 .||.||.|||.....| ||||||||.||||.. |   .. ||||.||.| .|| .|||.|  .||||| |..||||||. .| ..     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 281-440 3.3e-58 190.3 In-house 98-252 (255) alignment
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
 .||.||.|||.....| ||||||||.||||.. |   .. ||||.||.| .|| .|||.|  .||||| |..||||||. .| ..     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse

PPM_PTC7 281-440 1.7e-57 187.8 In-house 99-256 (259) alignment
Range on Protein: 281-440
Range on HMM: 99-256/259.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVT--CEGRVNGGLNLSRALGDHSYKGQSElgaHEQQITAM
 .||.||.|||. ...| ||||||||.||||.| |   .. ||||..|.| .|| .|||.|    .||||| |..|||.||. .| .     .||...| 
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae

PDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeeNLSSICEKLFDACLAPDTS
||| .|...| |||...|.||.|.| ..||.||.|..|.. .   .. ..||| | ..|....
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargse

subfamily_PPM1A_pd Subfamily PPM1A 248-457 2.4e-57 187.4 In-house 115-281 (282) alignment
Range on Protein: 248-457
Range on HMM: 115-281/282.0
EeeeeeeeeseeeeeeeededgegvlvksdevgydsGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVN
                                    |.||...||....| .||.|||| |||||| |  .. ||||...|| .||..|||.|.  .|||
s...................................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvn

GGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSgdgagcD
| | .||||||..|| ..|..|.||...| |... .  .| |.|.|.|||||| | ...|||..|..... . ..|......| | .|  ..       |
GaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsr......D

NMTCVIVSFK
|.....| |.
Nlsvlvvlfa

0049733 PP2C-like 280-457 9.1e-42 136.0 In-house 89-234 (235) alignment
Range on Protein: 280-457
Range on HMM: 89-234/235.0
GYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVtcegRVNGGLNLSRALGDHSYKgqselgaheqqitamPD
 . .||||.|||. .. |.||||||||..|.|.| .. .. ||.| .| |  ||..||| |    ||.|.| |.|||||. .|               ||
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............pd

IRQTTLTEADeFMVIACDGIWNVKNSQEVVDFVKQemkngeENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
.....|.. | |...|.||.|.| ...|.||....       .|. ..|.|....||      . |.||.|.|.| ..
vtvlelepgd.flllasDGlwdvlsdeeivdllrs......ldleeaaerlvelala......rggrDNiTvvvvrld

subfamily_PPM1E_pd Subfamily PPM1E 270-458 2e-40 131.7 In-house 89-264 (265) alignment
Range on Protein: 270-458
Range on HMM: 89-264/265.0
EGVLVKSDEVGYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKgqsel
| .| |. . .. ||.||.|.|.. ..| || .|||. .|.|.| |. .   ||||.|.| .|| .||| |   |  |||| |..|||.|| ..|     
erflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.....

gaheQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLFDACLAPDTSgdgagcDNMTCVIVSFKP
    . ... .|. ...|....|....||||.|.| | .|||. |.. ...|.|.||.. ..| .|    . |      ||.| |.| ..|
....pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfldp

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 278-455 7.5e-35 113.4 In-house 90-252 (255) alignment
Range on Protein: 278-455
Range on HMM: 90-252/255.0
EVGYDSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE---GRVNGGLNLSRALGDhSYkgqseLgahEQQ
| .   ||||...|. ..   .||||||| ||| ..|.|  .|.|||| .|.| .||...||.|  .    |||| | .|||||| |.     |   |  
erpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.sf.....l...ePf

ITAMPDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEmKNGEEnlssICEKLFDACLApdtSGdgaGCDNMTCVIVS
... ||.  . . .. |.|...||||||..   .| |. | .  .. |.     .||| |       ||     ||.. ... 
vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi.sdpek....aaeklrdlays...sG...stdnisvivik

subfamily_ILKAP_pd Subfamily ILKAP 281-421 3.4e-34 111.3 In-house 111-248 (293) alignment
Range on Protein: 281-421
Range on HMM: 111-248/293.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNG------IALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVNGGLNLSRALGDHSYKGqseLGaheqqI
.  |.||.| || || | |||.|||..||.|.       ... .. ||.| ...| .||.||||.|. .|||.| |. ||..||  .|.   ||     .
WkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkr...lG.....v

TAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEE
.. ||... .||| | |.|.||||.|.| . .|||.|. . ... |.
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeed

subfamily_PPM1L_pd Subfamily PPM1L 282-431 4e-33 107.8 In-house 105-251 (269) alignment
Range on Protein: 282-431
Range on HMM: 105-251/269.0
DSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKGQselgaheQQITAMP
 .||||..|||....|.|||||||| ||. ..|.|. .| ||||.. ||  ||.|||| .. .|  ||.| |  ||||||.  | .       . . | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadp

DIRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLF
||    | .   ||...|.||.|.    .| | |.|...|. .    |.  . |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesf

subfamily_PPM1K_pd Subfamily PPM1K 276-430 8.5e-32 103.3 In-house 91-242 (263) alignment
Range on Protein: 276-430
Range on HMM: 91-242/263.0
SDEVGYDSGTTAIVALVKD-NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE----GRVNGGLNLSRALGDHSYKgqselgah
...    ||||| |.|..| ..| .|..|||| .||||| |  ...||.|| |.| .||..|||.|. .     .||| | ..|.|||   |        
aeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk........

EQQITAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQeMKNGEENLSSICEKL
.  . | |. ..  .  .|| |.|.  ||| .| ||||. |.|..  .. ||  ....|. 
ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl.chdpeeaahalteqa

subfamily_PPM1G2_pd Subfamily PPM1G2 5-110 1e-28 93.1 In-house 2-112 (287) alignment
Range on Protein: 5-110
Range on HMM: 2-112/287.0
LSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTC---LLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVD
||.| .. .| . .|...  |.|||||.|..|||||.    ||. ..  ...||||.|||||..||.|..|.|  ..     .|||. .|.|.|.||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

ESIVSEEGLKE
|.....| ||.
eellkdeklkd

PPM_PTC7_SpoIIE 279-435 1.6e-28 93.1 In-house 85-222 (230) alignment
Range on Protein: 279-435
Range on HMM: 85-222/230.0
VGY--DSGTTAIVALVKDNN--LTVANVGDSRCVLCRN-GIaldmsidhkpedekELNRIhKAGGKVT---CEGRVNGGLNLSRALGDHSYKGqselgaH
  .  .||.||.|||.  ..  |.|||.|||...|.|. |               |  || .||| .     .|||.| |..|.| ||  ..        
edepsssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......t

EQQITAMPDiRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeenlssICEKLFDACL
.. ..| ||  ......  |||...|.||.|.|...||.||.|..|..        ..|.| . ..
DGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDi

subfamily_PDP_pd Subfamily PDP 283-422 4e-25 81.7 In-house 152-318 (398) alignment
Range on Protein: 283-422
Range on HMM: 152-318/398.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRN---G--IALDMSIDHKPEDEKELNRIHKAGG---K--VTCEGRVNGGLNLSRALGDHSYKGQSELGAH--
||..|..||.....| |||.||.|.||...   |   |  .|.|.  . |.|..||.|.     .  |  .||. | |  .|| ||  || ..||  .  
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl

EQ---------------QITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN
|.                .|| |.. .  |.|.| |.|.| ||.|.. ...|||. |.. ... .|.
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek

subfamily_KAPP-like_pd Subfamily KAPP-like 283-434 8e-24 77.1 In-house 100-249 (266) alignment
Range on Protein: 283-434
Range on HMM: 100-249/266.0
SGTTAIVALVK----DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAM
 |.|| .|||        | |||||||   |.|   .| .| ||| .|..|  ||.. |  .. .  |.| || .|||||||  | . ..|     ... 
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lise

PDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
| .  . .||  |.|...| ||.|.| . .. .. ||   . .. |....|    |... 
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta

subfamily_PP2D1_pd Subfamily PP2D1 282-418 1.2e-23 76.6 In-house 175-308 (492) alignment
Range on Protein: 282-418
Range on HMM: 175-308/492.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKV---TCEGRVNGGLNLSRALGDHsykGQSELgahEQQITAMP
..  .  | |..   | .||.|. . ||||.| |  .  .| |...|| .|..|||. |      |.||| |.  | || .   |. .|   .. .   |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
 .. ..|.||. |.|.|  |.|.| . .||.  ||| .. 
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlai

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 292-434 4.8e-22 71.1 In-house 113-259 (276) alignment
Range on Protein: 292-434
Range on HMM: 113-259/276.0
VKD----------NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAMPDI
|              | |||||||   |.|   .| .| ||| .| .| .||.. |  .. .  |.| || .|||||||  | . ..|     ... | .
vwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lisepyv

R-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
  . .||  |.|...| ||.|.| . .. .. ||   . .. |....|    |... 
snrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta

subfamily_PPM1A_pd Subfamily PPM1A 16-105 2.1e-21 69.5 In-house 6-105 (282) alignment
Range on Protein: 16-105
Range on HMM: 6-105/282.0
TESNSKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGY--------KEGNTKQALIDTFLKVDESIVSE
.... .. || |.||||||.||||||.  .. .  | |.|||.|||.|.|||.||.|||.. . ..  .        .. ..|.|| . ||..||.| ..
qaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel





subfamily_TAB1_pd Subfamily TAB1 283-415 7.9e-19 60.6 In-house 129-270 (333) alignment
Range on Protein: 283-415
Range on HMM: 129-270/333.0
SGTTAIVALVKDNNLTVANVGDSRCVLCR---NGIALDMSIDHKPEDEKELNRIHKAGG---KVTCEGRVnGGLNLSRALGDHSYKGQ----SEL-GAHE
 ||||.|||.  |.| |||||||| .|..   .     .| ||. . |.|| |... |    ..   .|. |. .  |..||.. |.       |  |..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QQITAMPDIRQT-TLTEADEFMVIACDGIwnVKNSQEVVDFVKQE
. . | |||  .  ....  |.|.  ||.  .|. .|| .  . .
ePviaePdiqgaypiddityflvlmSdGv..yktLeevtgpetsn

PPM_PTC7 23-104 9.6e-18 57.5 In-house 2-91 (259) alignment
Range on Protein: 23-104
Range on HMM: 2-91/259.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK--VDESIVS
 .||||.||.|.||||||..| ..     ... ..|||.|||||.|.|.|...||...|   .  .|. ....||...||.   ||.. |
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 280-360 1.8e-17 56.8 In-house 82-184 (292) alignment
Range on Protein: 280-360
Range on HMM: 82-184/292.0
GYDSGTTAIVALVKDN-NLTVANVGDSRCVLCR-----NGIALDMSIDHKPEDEKELNRIHKAGGKVT----------CEGRV------NGGLNLSRALG
.  ..|... | |.|. .| .|||||||..| |     .     .| ||||||  | .|| .|||.|.             ||      .|.| ||||||
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG

DHS
|  
dfh

PP2C Protein phosphatase 2C 23-104 6.7e-17 54.9 Pfam-A 2-90 (255) alignment
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
 .|||..||.| ||||||..| ..     ... ..|||.|||||.|.|.| ..||...|   .  .|. . ..||...||.  ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

PP2C Protein phosphatase 2C 23-104 6.7e-17 54.9 In-house 2-90 (255) alignment
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
 .|||..||.| ||||||..| ..     ... ..|||.|||||.|.|.| ..||...|   .  .|. . ..||...||.  ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

PPM_PTC7_motif 393-440 1.9e-15 50.1 In-house 1-48 (51) alignment
Range on Protein: 393-440
Range on HMM: 1-48/51.0
VIACDGIWNVKNSQEVVDFVKQEMK-NGEeNLSSICEKLFDACLAPDTS
..|.||.|.| ..||.||.|..... .|.  . ...||| | .||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAeklvdealargse

subfamily_PHLPP_pd Subfamily PHLPP 294-415 2.3e-15 49.2 In-house 104-215 (246) alignment
Range on Protein: 294-415
Range on HMM: 104-215/246.0
DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEkELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSykgqselgAHeQQITAMPDIRQTTLTEADEFMV
  .|.||.||    ||.|||  | .|  .. |.. ||.||..| . .| ....|| .. .| ||  .         .   .   | .|...||| ||...
sfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf........lf.PvvlPkphvrevlLteqdelli

IACDGIWNVKNSQEVVDFVKQE
.  . .|.| . .|.|. |..|
vGnkalWevlsideaveavrke

0049733 PP2C-like 21-104 7.5e-15 48.2 In-house 2-81 (235) alignment
Range on Protein: 21-104
Range on HMM: 2-81/235.0
KMSYGASAMQGW-RVSMEDAHTClldfdeDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGD-IGYKEGNTKQALIDTFLKVDESIVS
..|.||. ..|. |  .|||. .      ...||||.||||| ...|..|..|...|.    .. . ....||...||...| ...
rlsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle

PP2C_SIG_SM00331 278-455 2.7e-13 43.0 In-house 81-216 (217) alignment
Range on Protein: 278-455
Range on HMM: 81-216/217.0
EVGYDSGTTAIVALV--KDNNLTVANVGDSRCVLCRNGI-ALDMSIdhkpedekelnrihkaggkvtcegrvngglNLSRALG-DHS-Ykgqselgaheq
..  ....|...||.  ....| .||.||||..| |.|    . .                               .....||   .             
keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs...........

qitamPDIRQTTLTEaDEFMVIACDGIWNVKNS-----QEVVDFVKQEMKNGEENLSS-ICEKLFDACLAPDTsgdgagCDNMTCVIVS
     .|||...| . ....... ||.......     ... ..... ...  . |.. | |.|. .  .. .       |..| |.| 
.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvvk

subfamily_PPM1D_pd Subfamily PPM1D 283-343 1.3e-12 40.4 In-house 108-174 (309) alignment
Range on Protein: 283-343
Range on HMM: 108-174/309.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRNGI------ALDMSIDHKPEDEKELNRIHKAGGKVTCE
.|||| | ......| ||.||||. ||  .        |  .  |||||. .| .||...||.|. .
aGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak

subfamily_PPM1E_pd Subfamily PPM1E 24-105 2e-12 39.9 In-house 6-94 (265) alignment
Range on Protein: 24-105
Range on HMM: 6-94/265.0
YGASAMQGWRVSMEDAHTCLLDF----D----EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTkQALIDTFLKVDESIVSE
  . |... |  ||| | .| |.    .    .... |||.|||||.| |.| ..||. .|  .   ||  . .|| ..| ..||.... 
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk

PPM_PTC7_SpoIIE 24-105 2.3e-12 40.2 In-house 3-87 (230) alignment
Range on Protein: 24-105
Range on HMM: 3-87/230.0
YGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEvaEYVSKHLPDVLRGDIgYKEGN-TKQALIDTFLKVDESIVSE
.||||.||.| ||||||... ..     .    .....|||||..   .....| ..||  . .....  ...|....|...  . .|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede

subfamily_PPM1H_pd Subfamily PPM1H 281-329 9.8e-11 34.0 In-house 160-208 (404) alignment
Range on Protein: 281-329
Range on HMM: 160-208/404.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKE
   | ||.|||| .. | ||| |||| .|.|..   ..| |. || |..
ikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq

subfamily_PPM1D_pd Subfamily PPM1D 350-457 1.7e-10 33.5 In-house 201-308 (309) alignment
Range on Protein: 350-457
Range on HMM: 201-308/309.0
LNLSRALGD-HSYKGQSElgahEQQITAMPDIRQTTLTEADE-FMVIACDGIWNVKNSQEVVDFVKQEMKNG---EENLSSICEKLFDACLApDTSGDGA
|...|.|||  ||. .|.    |  .   ||. ..||. ..| |...| ||.||| .....|..|..| . .   ||. .|. ..| .  |   ..    
LavaRslGDlWsynaksg....efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskkl

GCDNMTCVIVSFK
 .||.. ..| ..
raDnvsvivvile

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 20-102 2.3e-10 33.2 In-house 4-88 (255) alignment
Range on Protein: 20-102
Range on HMM: 4-88/255.0
SKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESI
|..  | | | | | .|||  .    | .  |  ..|..|||||.. |.. |..|. .|.  .  .. | ...| ... ...  |
srfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi

subfamily_PPM1K_pd Subfamily PPM1K 24-105 2.4e-10 33.0 In-house 6-85 (263) alignment
Range on Protein: 24-105
Range on HMM: 6-85/263.0
YGASAMQGWRVSMEDaHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIgYKEGNTKQALIDTFLKVDESIVSE
 |  ...| |   ||   .|...|..   .||.|||.|.  |..| ..|  .|.     || . .. | ..|...|. . . 
vGkdsliGkraened.riklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkry

subfamily_PPM1D_pd Subfamily PPM1D 24-100 3.4e-10 32.5 In-house 4-88 (309) alignment
Range on Protein: 24-100
Range on HMM: 4-88/309.0
YGASAMQGWRVSMEDAHTCLLDFDE-----DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGN---TKQALIDTFLKVDE
  ..| || |  |||  .  |. .|     . . .||.|||||.| |.....||  |.. . ..   .     .|. ..||.. |
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflathe

subfamily_PPM1L_pd Subfamily PPM1L 25-103 7.5e-10 31.5 In-house 8-96 (269) alignment
Range on Protein: 25-103
Range on HMM: 8-96/269.0
GASAMQGWRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQA--------LIDTFLKVDESIV
 . ...| |  |||  .   | ...|  |.|||.|||||.  ||.. . |.. ..  .   . . ...        | |  | ||| ..
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekll

subfamily_PPM1H_pd Subfamily PPM1H 345-420 1.4e-09 30.2 In-house 276-355 (404) alignment
Range on Protein: 345-420
Range on HMM: 276-355/404.0
RVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE----ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGE
|. . .  .| ||||. |  ..       ....|..|.. ||.     |. ...| ||.|.| . .||   |.. ... |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve

Subfamily Dicty-PPM1L-like 273-341 3.6e-09 28.9 In-house 205-273 (305) alignment
Range on Protein: 273-341
Range on HMM: 205-273/305.0
LVKSDEVGyDSGTTAIVALVKDNNL-TVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVT
| || ..| | ... .|.  .|..|  ||. .|.. ||...|..  .| ....|. ||| |... ..|. 
lkksrskG.dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkie

subfamily_ILKAP_pd Subfamily ILKAP 28-104 4.6e-09 28.8 In-house 11-102 (293) alignment
Range on Protein: 28-104
Range on HMM: 11-102/293.0
AMQGWRVSMEDAHTCLLDFDED----------TSLFAVYDGHGGQEVAEYVSKHLPDVL-----RGDIGYKEGNTKQALIDTFLKVDESIVS
  .| |  |.|||. | |.||.           | .||.|||.|.  .|.....|  ..     ..|.  || . |..|.|.| |.||  ..
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLk

PPM_PTC7_SpoIIE_motif 387-456 5.9e-08 26.3 In-house 10-80 (81) alignment
Range on Protein: 387-456
Range on HMM: 10-80/81.0
EADEFMVIACDGIW-------NVKNSQEVVDFVKQEmkNG-EenLSSICEKLFDACLApdtSGDGAGCDNMTCVIVSF
.... .....||..       .... .|........   | .  | ....||.|..|.    |.|   |..| ... .
kpgdvllLyTDGltEardsdgelfgkeellrladra..egks..lqeladklvdevle...ngsgereDDitllvlrv

subfamily_PP2D1_pd Subfamily PP2D1 32-78 1.4e-07 23.6 In-house 13-61 (492) alignment
Range on Protein: 32-78
Range on HMM: 13-61/492.0
WRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRG
|. .|||..|   .| .|.  . |..|||. |.  ||  .|.|..||  
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlle

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 281-443 3.6e-07 21.7 In-house 132-308 (317) alignment
Range on Protein: 281-443
Range on HMM: 132-308/317.0
YDSGTTAIVALVKDNN-LTVANVGD--SRCVL-------CRNGIALD-MSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGA
 | ||||.||.| |.  ..||| ||  .  .|        |.|. .. .|. |. . ..| .|.... .. .     .    |  || ..  .    || 
ldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGh

HE---QQITAMPDIRQTTLTEADEFMVIAC-DGIWNVKNSQEVVDFVKQEMkNGEENLSSICEKLFDACLAPDTSGDG
.      ..| |..|  .|   . | |... ||| .  . ..|.| | .      |    .|.   | .|. ... | 
kllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraa.taleasevlcddaqdylldetsidda

Subfamily Dicty-PPM1L-like 332-418 4.9e-07 21.9 In-house 185-265 (305) alignment
Range on Protein: 332-418
Range on HMM: 185-265/305.0
RIHKAGGKVTCEGR--VNGGLNLSRALGDhsyKGQSELGAheqqitAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
||  ... .   |.  ||. |. ||  ||   |.  || .        .|     .    |.|.|.| ||.|.| . |.||..||. ...
rieslqaalynygellvnrllkksrskGd...knlkelvi......PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrd

PP2C_2 Protein phosphatase 2C 277-421 1.2e-06 21.0 Pfam-A 91-200 (212) alignment
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.|   | .|| ..|....... ....||... |  |.| .  ...... | . |.... ..  ....                                 
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................

itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
     .||. . .|. .  ..  ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee

PP2C_2 Protein phosphatase 2C 277-421 1.2e-06 21.0 In-house 91-200 (212) alignment
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.|   | .|| ..|....... ....||... |  |.| .  ...... | . |.... ..  ....                                 
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................

itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
     .||. . .|. .  ..  ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee

Subfamily Dicty-PPM1L-like 23-76 2.2e-06 19.7 In-house 8-63 (305) alignment
Range on Protein: 23-76
Range on HMM: 8-63/305.0
SYGASAMQGWRVSMEDAHTCLLD--FDEDTSLFAVYDGHGGQEVAEYVSKHLPDVL
 |.  . .. |   || .   .    ... ||| |.|||.|.  |||| |.| ...
kyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveiv

subfamily_PDP_pd Subfamily PDP 36-74 7.2e-06 18.3 In-house 11-49 (398) alignment
Range on Protein: 36-74
Range on HMM: 11-49/398.0
MEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPD
.|| ..     ...  ||.| |||||.  || |||.|..
iEDrrseakllesngvlfgvfDGHggaacaeavskrLlk