Gene PPM1G in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP145_AA protein Get Run
NvecP145_AA_2-457 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-458 2.2e-202 666.2 In-house 1-472 (473) alignment 
Range on Protein: 4-458
Range on HMM: 1-472/473.0
YLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESIV
||||||.|..|..|||...|||||||||||||.||||.|..|.|||||||||||||||.|||.||.|.|||.|. . |||||....|| ..||..||...
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

SEEGLKELKEIAG--DNDDS------GDENEADLLTKDANIPLSELLAKLKENNLELKDVYVIALQRANENEEDSGEDSEEEEENGHLMNGDSKTEEKKN
.|| ||||||||.  ...|.       ||.|..|||..|.|||.|||..|.... | .......|..|....|......|||||. . ....||.||||.
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrldgdgsekeelsqallegaasedeedededeeeeeeekdteeeskeeekka

ANGKMGQKERHSEDEEEKENKDDSKSADKDDDKGVDEKGVDEEGASEEPQDGEEEEEEEEESEEEEEEEEDEDGEGVLV--------KSDEVGYDSGTTA
...|.|..|...|||.|||.....|.....|.||..|....|....|| .|.||.||||||..||.||||.|||||...        ...|.|.||||||
kaakegkqekkeedesekeeeeeekeeeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttA

IVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE
.|||.|...|.|||.|||||||.||| |||.|.|||||||.||.||.||||||...||||||||||||||||.|| ..||...||.|.|.|||...||||
vvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlte

ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN-LSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSFKP
.|||.|.||||||||..||||||||....|.|||. ||.|.|.|.||||||||||||.||||||..||..|.
edeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
PP2Cc_SM00332 14-454 3.6e-88 288.5 In-house 2-274 (274) alignment 
Range on Protein: 14-454
Range on HMM: 2-274/274.0
SVTESNSKMSYGASAMQGWRVSMEDAHTCLLDFD--EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG----NTKQALIDTFLKVDESIVSEEG
|...||...||| |.|||||.|||||| . .|..  ||...|.|.|||||.|||..|||.||. |   . .|..    ....|| . ||..|| |. || 
sesgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

LKELKEiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdskteekknangkmgqkerhs
 |||..                                                                                              
skelen..............................................................................................

edeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdevgYDSGTTAIVALVKDNNLTVANVGDSRC
                                                                          .||.||.|||.|...| ||||||||.
.........................................................................alsGstavvallkkedlyvanvGDSra

VLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEgRVNGGLNLSRALGDHSYKGQSelGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQE
|||||| |...| |||||||.|..||.||||.|  . ||||||..|||.||| .| ..  .  |. ||| ||. ..|||..|||...|.||.|.| ..||
vlcrngkavqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqe

VVDFVKQEMKNGEENLSSICEKLFDACLAPDtsgdGAGCDNMTCVIV
|||.|.. ...|..|  . ...| |......    | ..||.|.|.|
vvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvvv
0034914 PP2C-like 3-457 4.5e-81 264.7 In-house 2-291 (295) alignment 
Range on Protein: 3-457
Range on HMM: 2-291/295.0
AYLSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTCLLDF---DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRG-------DIGYKEGNTKQALI
..||.|..|. ... .. ....|.. .||.| |.|||....|..   .||..||.|.||||| ..||..|..|.. |.           . . . ..||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

DTFLKVDESIVSEEGLKelkeiagdnddsgdeneadlltkdaniplsellaklkennlelkdvyvialqraneneedsgedseeeeenghlmngdsktee
..||..|| ....  |.                                                                                   
kaflaadeellelallr...................................................................................

kknangkmgqkerhsedeeekenkddsksadkdddkgvdekgvdeegaseepqdgeeeeeeeeeseeeeeeeededgegvlvksdEVGYDSGTTAIVALV
                                                                                        . |||||.|||.
.....................................................................................pelagsGtTavvali

KDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLT-EADEF
..| |.||||||||.||.||| .. ...|||| .| |  || .||| |.  |||||.|...|||||...| .  | ..|. ..|.||.....|| | |.|
rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddf

MVIACDGIWNVKNSQEVVDFVKQEMKnGEENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
...|.||.|.| ...|.||.|.. .. .  .|. ..|.| |..||      . ..||.|.|.| ..
llLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla......rgsrDNiTvvvvrln
subfamily_PPM1G2_pd Subfamily PPM1G2 282-456 1e-67 221.1 In-house 114-286 (287) alignment 
Range on Protein: 282-456
Range on HMM: 114-286/287.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCeGRVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIR
..|.||.|.|.|...| |||.||||.||. .| .  .|.||||..|.| .|| .||| |   .|||| | |||||||...| .......||..||.||. 
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvel.nrvngnLalsralgDfefkknvkkkpeeqivtavPDvl

QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSGDGAGCDNMTCVIVSF
 . |.| |||.|.||||||.| ...||||.|......|  .|..|.|.|.| |||||.|  | ||||||.|||..
vkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvl
PP2C Protein phosphatase 2C 281-440 3.3e-58 190.3 Pfam-A 98-252 (255) alignment 
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
 .||.||.|||.....| ||||||||.||||.. |   .. ||||.||.| .|| .|||.|  .||||| |..||||||. .| ..     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 281-440 3.3e-58 190.3 In-house 98-252 (255) alignment 
Range on Protein: 281-440
Range on HMM: 98-252/255.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSelgahEQQITAMPD
 .||.||.|||.....| ||||||||.||||.. |   .. ||||.||.| .|| .|||.|  .||||| |..||||||. .| ..     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEeNLSSICEKLFDACLAPDTS
.....||| |||...|.||.|.| ..||.||.|..|.. .. ... ..|.| | ..|. ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
PPM_PTC7 281-440 1.7e-57 187.8 In-house 99-256 (259) alignment 
Range on Protein: 281-440
Range on HMM: 99-256/259.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIAL-DMSIDHKPEDEKELNRIHKAGGKVT--CEGRVNGGLNLSRALGDHSYKGQSElgaHEQQITAM
 .||.||.|||. ...| ||||||||.||||.| |   .. ||||..|.| .|| .|||.|    .||||| |..|||.||. .| .     .||...| 
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae

PDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeeNLSSICEKLFDACLAPDTS
||| .|...| |||...|.||.|.| ..||.||.|..|.. .   .. ..||| | ..|....
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargse
subfamily_PPM1A_pd Subfamily PPM1A 248-457 2.4e-57 187.4 In-house 115-281 (282) alignment 
Range on Protein: 248-457
Range on HMM: 115-281/282.0
EeeeeeeeeseeeeeeeededgegvlvksdevgydsGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVN
                                    |.||...||....| .||.|||| |||||| |  .. ||||...|| .||..|||.|.  .|||
s...................................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvn

GGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeENLSSICEKLFDACLAPDTSgdgagcD
| | .||||||..|| ..|..|.||...| |... .  .| |.|.|.|||||| | ...|||..|..... . ..|......| | .|  ..       |
GaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsr......D

NMTCVIVSFK
|.....| |.
Nlsvlvvlfa
0049733 PP2C-like 280-457 9.1e-42 136.0 In-house 89-234 (235) alignment 
Range on Protein: 280-457
Range on HMM: 89-234/235.0
GYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVtcegRVNGGLNLSRALGDHSYKgqselgaheqqitamPD
 . .||||.|||. .. |.||||||||..|.|.| .. .. ||.| .| |  ||..||| |    ||.|.| |.|||||. .|               ||
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............pd

IRQTTLTEADeFMVIACDGIWNVKNSQEVVDFVKQemkngeENLSSICEKLFDACLApdtsgdGAGCDNMTCVIVSFK
.....|.. | |...|.||.|.| ...|.||....       .|. ..|.|....||      . |.||.|.|.| ..
vtvlelepgd.flllasDGlwdvlsdeeivdllrs......ldleeaaerlvelala......rggrDNiTvvvvrld
subfamily_PPM1E_pd Subfamily PPM1E 270-458 2e-40 131.7 In-house 89-264 (265) alignment 
Range on Protein: 270-458
Range on HMM: 89-264/265.0
EGVLVKSDEVGYDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKgqsel
| .| |. . .. ||.||.|.|.. ..| || .|||. .|.|.| |. .   ||||.|.| .|| .||| |   |  |||| |..|||.|| ..|     
erflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.....

gaheQQITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLFDACLAPDTSgdgagcDNMTCVIVSFKP
    . ... .|. ...|....|....||||.|.| | .|||. |.. ...|.|.||.. ..| .|    . |      ||.| |.| ..|
....pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfldp
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 278-455 7.5e-35 113.4 In-house 90-252 (255) alignment 
Range on Protein: 278-455
Range on HMM: 90-252/255.0
EVGYDSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE---GRVNGGLNLSRALGDhSYkgqseLgahEQQ
| .   ||||...|. ..   .||||||| ||| ..|.|  .|.|||| .|.| .||...||.|  .    |||| | .|||||| |.     |   |  
erpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.sf.....l...ePf

ITAMPDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEmKNGEEnlssICEKLFDACLApdtSGdgaGCDNMTCVIVS
... ||.  . . .. |.|...||||||..   .| |. | .  .. |.     .||| |       ||     ||.. ... 
vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi.sdpek....aaeklrdlays...sG...stdnisvivik
subfamily_ILKAP_pd Subfamily ILKAP 281-421 3.4e-34 111.3 In-house 111-248 (293) alignment 
Range on Protein: 281-421
Range on HMM: 111-248/293.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNG------IALDMSIDHKPEDEKELNRIHKAGGKVTcEGRVNGGLNLSRALGDHSYKGqseLGaheqqI
.  |.||.| || || | |||.|||..||.|.       ... .. ||.| ...| .||.||||.|. .|||.| |. ||..||  .|.   ||     .
WkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkr...lG.....v

TAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEE
.. ||... .||| | |.|.||||.|.| . .|||.|. . ... |.
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeed
subfamily_PPM1L_pd Subfamily PPM1L 282-431 4e-33 107.8 In-house 105-251 (269) alignment 
Range on Protein: 282-431
Range on HMM: 105-251/269.0
DSGTTAIVALVKDNNLTVANVGDSRCVLC-RNGIALDMSIDHKPEDEKELNRIHKAGGKVTCEG--RVNGGLNLSRALGDHSYKGQselgaheQQITAMP
 .||||..|||....|.|||||||| ||. ..|.|. .| ||||.. ||  ||.|||| .. .|  ||.| |  ||||||.  | .       . . | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadp

DIRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEENLSSICEKLF
||    | .   ||...|.||.|.    .| | |.|...|. .    |.  . |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesf
subfamily_PPM1K_pd Subfamily PPM1K 276-430 8.5e-32 103.3 In-house 91-242 (263) alignment 
Range on Protein: 276-430
Range on HMM: 91-242/263.0
SDEVGYDSGTTAIVALVKD-NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE----GRVNGGLNLSRALGDHSYKgqselgah
...    ||||| |.|..| ..| .|..|||| .||||| |  ...||.|| |.| .||..|||.|. .     .||| | ..|.|||   |        
aeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk........

EQQITAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQeMKNGEENLSSICEKL
.  . | |. ..  .  .|| |.|.  ||| .| ||||. |.|..  .. ||  ....|. 
ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl.chdpeeaahalteqa
subfamily_PPM1G2_pd Subfamily PPM1G2 5-110 1e-28 93.1 In-house 2-112 (287) alignment 
Range on Protein: 5-110
Range on HMM: 2-112/287.0
LSKPKTEMNSVTESNSKMSYGASAMQGWRVSMEDAHTC---LLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVD
||.| .. .| . .|...  |.|||||.|..|||||.    ||. ..  ...||||.|||||..||.|..|.|  ..     .|||. .|.|.|.||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

ESIVSEEGLKE
|.....| ||.
eellkdeklkd
PPM_PTC7_SpoIIE 279-435 1.6e-28 93.1 In-house 85-222 (230) alignment 
Range on Protein: 279-435
Range on HMM: 85-222/230.0
VGY--DSGTTAIVALVKDNN--LTVANVGDSRCVLCRN-GIaldmsidhkpedekELNRIhKAGGKVT---CEGRVNGGLNLSRALGDHSYKGqselgaH
  .  .||.||.|||.  ..  |.|||.|||...|.|. |               |  || .||| .     .|||.| |..|.| ||  ..        
edepsssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......t

EQQITAMPDiRQTTLTEA-DEFMVIACDGIWNVKNSQEVVDFVKQEMKNGeenlssICEKLFDACL
.. ..| ||  ......  |||...|.||.|.|...||.||.|..|..        ..|.| . ..
DGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDi
subfamily_PDP_pd Subfamily PDP 283-422 4e-25 81.7 In-house 152-318 (398) alignment 
Range on Protein: 283-422
Range on HMM: 152-318/398.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRN---G--IALDMSIDHKPEDEKELNRIHKAGG---K--VTCEGRVNGGLNLSRALGDHSYKGQSELGAH--
||..|..||.....| |||.||.|.||...   |   |  .|.|.  . |.|..||.|.     .  |  .||. | |  .|| ||  || ..||  .  
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl

EQ---------------QITAMPDIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGEEN
|.                .|| |.. .  |.|.| |.|.| ||.|.. ...|||. |.. ... .|.
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
subfamily_KAPP-like_pd Subfamily KAPP-like 283-434 8e-24 77.1 In-house 100-249 (266) alignment 
Range on Protein: 283-434
Range on HMM: 100-249/266.0
SGTTAIVALVK----DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAM
 |.|| .|||        | |||||||   |.|   .| .| ||| .|..|  ||.. |  .. .  |.| || .|||||||  | . ..|     ... 
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lise

PDIR-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
| .  . .||  |.|...| ||.|.| . .. .. ||   . .. |....|    |... 
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta
subfamily_PP2D1_pd Subfamily PP2D1 282-418 1.2e-23 76.6 In-house 175-308 (492) alignment 
Range on Protein: 282-418
Range on HMM: 175-308/492.0
DSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKV---TCEGRVNGGLNLSRALGDHsykGQSELgahEQQITAMP
..  .  | |..   | .||.|. . ||||.| |  .  .| |...|| .|..|||. |      |.||| |.  | || .   |. .|   .. .   |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DIRQTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
 .. ..|.||. |.|.|  |.|.| . .||.  ||| .. 
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlai
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 292-434 4.8e-22 71.1 In-house 113-259 (276) alignment 
Range on Protein: 292-434
Range on HMM: 113-259/276.0
VKD----------NNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVTCE-GRVNgGLNLSRALGDHSYKGQsELGaheqqITAMPDI
|              | |||||||   |.|   .| .| ||| .| .| .||.. |  .. .  |.| || .|||||||  | . ..|     ... | .
vwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.niG.....lisepyv

R-QTTLTEADEFMVIACDGIWNVKNSQEVVDFVKQ--EMKNGEENLSSiceKLFDAC
  . .||  |.|...| ||.|.| . .. .. ||   . .. |....|    |... 
snrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmas...slleta
subfamily_PPM1A_pd Subfamily PPM1A 16-105 2.1e-21 69.5 In-house 6-105 (282) alignment 
Range on Protein: 16-105
Range on HMM: 6-105/282.0
TESNSKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGY--------KEGNTKQALIDTFLKVDESIVSE
.... .. || |.||||||.||||||.  .. .  | |.|||.|||.|.|||.||.|||.. . ..  .        .. ..|.|| . ||..||.| ..
qaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel
subfamily_TAB1_pd Subfamily TAB1 283-415 7.9e-19 60.6 In-house 129-270 (333) alignment 
Range on Protein: 283-415
Range on HMM: 129-270/333.0
SGTTAIVALVKDNNLTVANVGDSRCVLCR---NGIALDMSIDHKPEDEKELNRIHKAGG---KVTCEGRVnGGLNLSRALGDHSYKGQ----SEL-GAHE
 ||||.|||.  |.| |||||||| .|..   .     .| ||. . |.|| |... |    ..   .|. |. .  |..||.. |.       |  |..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QQITAMPDIRQT-TLTEADEFMVIACDGIwnVKNSQEVVDFVKQE
. . | |||  .  ....  |.|.  ||.  .|. .|| .  . .
ePviaePdiqgaypiddityflvlmSdGv..yktLeevtgpetsn
PPM_PTC7 23-104 9.6e-18 57.5 In-house 2-91 (259) alignment 
Range on Protein: 23-104
Range on HMM: 2-91/259.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK--VDESIVS
 .||||.||.|.||||||..| ..     ... ..|||.|||||.|.|.|...||...|   .  .|. ....||...||.   ||.. |
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 280-360 1.8e-17 56.8 In-house 82-184 (292) alignment 
Range on Protein: 280-360
Range on HMM: 82-184/292.0
GYDSGTTAIVALVKDN-NLTVANVGDSRCVLCR-----NGIALDMSIDHKPEDEKELNRIHKAGGKVT----------CEGRV------NGGLNLSRALG
.  ..|... | |.|. .| .|||||||..| |     .     .| ||||||  | .|| .|||.|.             ||      .|.| ||||||
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG

DHS
|  
dfh
PP2C Protein phosphatase 2C 23-104 6.7e-17 54.9 Pfam-A 2-90 (255) alignment 
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
 .|||..||.| ||||||..| ..     ... ..|||.|||||.|.|.| ..||...|   .  .|. . ..||...||.  ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
PP2C Protein phosphatase 2C 23-104 6.7e-17 54.9 In-house 2-90 (255) alignment 
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEG-NTKQALIDTFLK-VDESIVS
 .|||..||.| ||||||..| ..     ... ..|||.|||||.|.|.| ..||...|   .  .|. . ..||...||.  ||.. |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
PPM_PTC7_motif 393-440 1.9e-15 50.1 In-house 1-48 (51) alignment 
Range on Protein: 393-440
Range on HMM: 1-48/51.0
VIACDGIWNVKNSQEVVDFVKQEMK-NGEeNLSSICEKLFDACLAPDTS
..|.||.|.| ..||.||.|..... .|.  . ...||| | .||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAeklvdealargse
subfamily_PHLPP_pd Subfamily PHLPP 294-415 2.3e-15 49.2 In-house 104-215 (246) alignment 
Range on Protein: 294-415
Range on HMM: 104-215/246.0
DNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEkELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSykgqselgAHeQQITAMPDIRQTTLTEADEFMV
  .|.||.||    ||.|||  | .|  .. |.. ||.||..| . .| ....|| .. .| ||  .         .   .   | .|...||| ||...
sfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf........lf.PvvlPkphvrevlLteqdelli

IACDGIWNVKNSQEVVDFVKQE
.  . .|.| . .|.|. |..|
vGnkalWevlsideaveavrke
0049733 PP2C-like 21-104 7.5e-15 48.2 In-house 2-81 (235) alignment 
Range on Protein: 21-104
Range on HMM: 2-81/235.0
KMSYGASAMQGW-RVSMEDAHTClldfdeDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGD-IGYKEGNTKQALIDTFLKVDESIVS
..|.||. ..|. |  .|||. .      ...||||.||||| ...|..|..|...|.    .. . ....||...||...| ...
rlsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle
PP2C_SIG_SM00331 278-455 2.7e-13 43.0 In-house 81-216 (217) alignment 
Range on Protein: 278-455
Range on HMM: 81-216/217.0
EVGYDSGTTAIVALV--KDNNLTVANVGDSRCVLCRNGI-ALDMSIdhkpedekelnrihkaggkvtcegrvngglNLSRALG-DHS-Ykgqselgaheq
..  ....|...||.  ....| .||.||||..| |.|    . .                               .....||   .             
keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs...........

qitamPDIRQTTLTEaDEFMVIACDGIWNVKNS-----QEVVDFVKQEMKNGEENLSS-ICEKLFDACLAPDTsgdgagCDNMTCVIVS
     .|||...| . ....... ||.......     ... ..... ...  . |.. | |.|. .  .. .       |..| |.| 
.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvvk
subfamily_PPM1D_pd Subfamily PPM1D 283-343 1.3e-12 40.4 In-house 108-174 (309) alignment 
Range on Protein: 283-343
Range on HMM: 108-174/309.0
SGTTAIVALVKDNNLTVANVGDSRCVLCRNGI------ALDMSIDHKPEDEKELNRIHKAGGKVTCE
.|||| | ......| ||.||||. ||  .        |  .  |||||. .| .||...||.|. .
aGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_PPM1E_pd Subfamily PPM1E 24-105 2e-12 39.9 In-house 6-94 (265) alignment 
Range on Protein: 24-105
Range on HMM: 6-94/265.0
YGASAMQGWRVSMEDAHTCLLDF----D----EDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTkQALIDTFLKVDESIVSE
  . |... |  ||| | .| |.    .    .... |||.|||||.| |.| ..||. .|  .   ||  . .|| ..| ..||.... 
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk
PPM_PTC7_SpoIIE 24-105 2.3e-12 40.2 In-house 3-87 (230) alignment 
Range on Protein: 24-105
Range on HMM: 3-87/230.0
YGASAMQGWRVSMEDAHTCLLDF-----DEDTSLFAVYDGHGGQEvaEYVSKHLPDVLRGDIgYKEGN-TKQALIDTFLKVDESIVSE
.||||.||.| ||||||... ..     .    .....|||||..   .....| ..||  . .....  ...|....|...  . .|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede
subfamily_PPM1H_pd Subfamily PPM1H 281-329 9.8e-11 34.0 In-house 160-208 (404) alignment 
Range on Protein: 281-329
Range on HMM: 160-208/404.0
YDSGTTAIVALVKDNNLTVANVGDSRCVLCRNGIALDMSIDHKPEDEKE
   | ||.|||| .. | ||| |||| .|.|..   ..| |. || |..
ikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq
subfamily_PPM1D_pd Subfamily PPM1D 350-457 1.7e-10 33.5 In-house 201-308 (309) alignment 
Range on Protein: 350-457
Range on HMM: 201-308/309.0
LNLSRALGD-HSYKGQSElgahEQQITAMPDIRQTTLTEADE-FMVIACDGIWNVKNSQEVVDFVKQEMKNG---EENLSSICEKLFDACLApDTSGDGA
|...|.|||  ||. .|.    |  .   ||. ..||. ..| |...| ||.||| .....|..|..| . .   ||. .|. ..| .  |   ..    
LavaRslGDlWsynaksg....efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskkl

GCDNMTCVIVSFK
 .||.. ..| ..
raDnvsvivvile
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 20-102 2.3e-10 33.2 In-house 4-88 (255) alignment 
Range on Protein: 20-102
Range on HMM: 4-88/255.0
SKMSYGASAMQGWRVSMEDAHTCLLDFDE--DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQALIDTFLKVDESI
|..  | | | | | .|||  .    | .  |  ..|..|||||.. |.. |..|. .|.  .  .. | ...| ... ...  |
srfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi
subfamily_PPM1K_pd Subfamily PPM1K 24-105 2.4e-10 33.0 In-house 6-85 (263) alignment 
Range on Protein: 24-105
Range on HMM: 6-85/263.0
YGASAMQGWRVSMEDaHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIgYKEGNTKQALIDTFLKVDESIVSE
 |  ...| |   ||   .|...|..   .||.|||.|.  |..| ..|  .|.     || . .. | ..|...|. . . 
vGkdsliGkraened.riklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkry
subfamily_PPM1D_pd Subfamily PPM1D 24-100 3.4e-10 32.5 In-house 4-88 (309) alignment 
Range on Protein: 24-100
Range on HMM: 4-88/309.0
YGASAMQGWRVSMEDAHTCLLDFDE-----DTSLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGN---TKQALIDTFLKVDE
  ..| || |  |||  .  |. .|     . . .||.|||||.| |.....||  |.. . ..   .     .|. ..||.. |
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflathe
subfamily_PPM1L_pd Subfamily PPM1L 25-103 7.5e-10 31.5 In-house 8-96 (269) alignment 
Range on Protein: 25-103
Range on HMM: 8-96/269.0
GASAMQGWRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRGDIGYKEGNTKQA--------LIDTFLKVDESIV
 . ...| |  |||  .   | ...|  |.|||.|||||.  ||.. . |.. ..  .   . . ...        | |  | ||| ..
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekll
subfamily_PPM1H_pd Subfamily PPM1H 345-420 1.4e-09 30.2 In-house 276-355 (404) alignment 
Range on Protein: 345-420
Range on HMM: 276-355/404.0
RVNGGLNLSRALGDHSYKGQSELGAHEQQITAMPDIRQTTLTE----ADEFMVIACDGIWNVKNSQEVVDFVKQEMKNGE
|. . .  .| ||||. |  ..       ....|..|.. ||.     |. ...| ||.|.| . .||   |.. ... |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
Subfamily Dicty-PPM1L-like 273-341 3.6e-09 28.9 In-house 205-273 (305) alignment 
Range on Protein: 273-341
Range on HMM: 205-273/305.0
LVKSDEVGyDSGTTAIVALVKDNNL-TVANVGDSRCVLCRNGIALDMSIDHKPEDEKELNRIHKAGGKVT
| || ..| | ... .|.  .|..|  ||. .|.. ||...|..  .| ....|. ||| |... ..|. 
lkksrskG.dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkie
subfamily_ILKAP_pd Subfamily ILKAP 28-104 4.6e-09 28.8 In-house 11-102 (293) alignment 
Range on Protein: 28-104
Range on HMM: 11-102/293.0
AMQGWRVSMEDAHTCLLDFDED----------TSLFAVYDGHGGQEVAEYVSKHLPDVL-----RGDIGYKEGNTKQALIDTFLKVDESIVS
  .| |  |.|||. | |.||.           | .||.|||.|.  .|.....|  ..     ..|.  || . |..|.|.| |.||  ..
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLk
PPM_PTC7_SpoIIE_motif 387-456 5.9e-08 26.3 In-house 10-80 (81) alignment 
Range on Protein: 387-456
Range on HMM: 10-80/81.0
EADEFMVIACDGIW-------NVKNSQEVVDFVKQEmkNG-EenLSSICEKLFDACLApdtSGDGAGCDNMTCVIVSF
.... .....||..       .... .|........   | .  | ....||.|..|.    |.|   |..| ... .
kpgdvllLyTDGltEardsdgelfgkeellrladra..egks..lqeladklvdevle...ngsgereDDitllvlrv
subfamily_PP2D1_pd Subfamily PP2D1 32-78 1.4e-07 23.6 In-house 13-61 (492) alignment 
Range on Protein: 32-78
Range on HMM: 13-61/492.0
WRVSMEDAHTCLLDFDEDT--SLFAVYDGHGGQEVAEYVSKHLPDVLRG
|. .|||..|   .| .|.  . |..|||. |.  ||  .|.|..||  
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlle
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 281-443 3.6e-07 21.7 In-house 132-308 (317) alignment 
Range on Protein: 281-443
Range on HMM: 132-308/317.0
YDSGTTAIVALVKDNN-LTVANVGD--SRCVL-------CRNGIALD-MSIDHKPEDEKELNRIHKAGGKVTCEGRVNGGLNLSRALGDHSYKGQSELGA
 | ||||.||.| |.  ..||| ||  .  .|        |.|. .. .|. |. . ..| .|.... .. .     .    |  || ..  .    || 
ldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGh

HE---QQITAMPDIRQTTLTEADEFMVIAC-DGIWNVKNSQEVVDFVKQEMkNGEENLSSICEKLFDACLAPDTSGDG
.      ..| |..|  .|   . | |... ||| .  . ..|.| | .      |    .|.   | .|. ... | 
kllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraa.taleasevlcddaqdylldetsidda
Subfamily Dicty-PPM1L-like 332-418 4.9e-07 21.9 In-house 185-265 (305) alignment 
Range on Protein: 332-418
Range on HMM: 185-265/305.0
RIHKAGGKVTCEGR--VNGGLNLSRALGDhsyKGQSELGAheqqitAMPDIRQTTL-TEADEFMVIACDGIWNVKNSQEVVDFVKQEMKN
||  ... .   |.  ||. |. ||  ||   |.  || .        .|     .    |.|.|.| ||.|.| . |.||..||. ...
rieslqaalynygellvnrllkksrskGd...knlkelvi......PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrd
PP2C_2 Protein phosphatase 2C 277-421 1.2e-06 21.0 Pfam-A 91-200 (212) alignment 
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.|   | .|| ..|....... ....||... |  |.| .  ...... | . |.... ..  ....                                 
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................

itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
     .||. . .|. .  ..  ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee
PP2C_2 Protein phosphatase 2C 277-421 1.2e-06 21.0 In-house 91-200 (212) alignment 
Range on Protein: 277-421
Range on HMM: 91-200/212.0
DEVGYDSGTTAIVALVKDNNLTVANVGDSRC-VLCRNGIALDMSIDHKPEDEKELNRIHKA--GGKVtcegrvngglnlsralgdhsykgqselgaheqq
.|   | .|| ..|....... ....||... |  |.| .  ...... | . |.... ..  ....                                 
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.................................

itampDIRQTTlTEADEFMVIACDGIW-NVKNSQEVVDFVKQEMKNGEE
     .||. . .|. .  ..  ||.. ........ ..... ... ||
.....rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletlee
Subfamily Dicty-PPM1L-like 23-76 2.2e-06 19.7 In-house 8-63 (305) alignment 
Range on Protein: 23-76
Range on HMM: 8-63/305.0
SYGASAMQGWRVSMEDAHTCLLD--FDEDTSLFAVYDGHGGQEVAEYVSKHLPDVL
 |.  . .. |   || .   .    ... ||| |.|||.|.  |||| |.| ...
kyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveiv
subfamily_PDP_pd Subfamily PDP 36-74 7.2e-06 18.3 In-house 11-49 (398) alignment 
Range on Protein: 36-74
Range on HMM: 11-49/398.0
MEDAHTCLLDFDEDTSLFAVYDGHGGQEVAEYVSKHLPD
.|| ..     ...  ||.| |||||.  || |||.|..
iEDrrseakllesngvlfgvfDGHggaacaeavskrLlk