Gene PPM1G2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP146_AA protein Get Run
NvecP146_AA_2-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 4-286 1.8e-144 473.0 In-house 1-286 (287) alignment 
Range on Protein: 4-286
Range on HMM: 1-286/287.0
TLSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTE---ILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSC
||||||..||..||.|...|..||.|||.|.||||||..   .|....||..|...|.||||||.||.|.|..|.||||.......|.. ..||..||..
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DTDMLKDEQMKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDKKPP
|...||||..|||.||.|||||.||..|||.||.|||||....|| |..|||||||..|.|..|||||||.||.||||||||||||||||.||||.||.|
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EEQIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQMGGLGCDNMTVIILTF
|||||||.|||.||.|..|.||||||||||||||.|.||||..|.||.....|..|.||||..|||||....|.|||||||.|...
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2Cc_SM00332 16-283 1.1e-97 319.7 In-house 4-273 (274) alignment 
Range on Protein: 16-283
Range on HMM: 4-273/274.0
SCSNKSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG----NVIEALKKGFLSCDTDMLKDEQMK
| ||...  . |.||||| .|||||  ...|.| ....| ||.|||||..||..| ..| . ..... . |.    .| |||||.|||.| ..|..||.|
sgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqsk

DE---VAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDkkPPEEQIVTAM
 .    .|.||||...|...||.||||||||. |..| . ||| ||||..|.|..|| .|||.||..||||.||.|||.||...|||.  ...|...|| 
elenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitae

PDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM-ELEQICEELLTRCLAPDcqmgGLGCDNMTVII
||| | .||...|||.||.||.|||||||||||..|..||..  .  | ..|||.......    | ..||.||..
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvv
0034914 PP2C-like 3-286 1.8e-89 292.2 In-house 2-290 (295) alignment 
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTEILSLKE-DKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ-------PAWAKGNVIEALK
..|| |.... ..| .. ... .....||.| ..|||.. .|.|   .......||.||||| ..|... ..| . ....         .   ...|||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

KGFLSCDTDMLKDEQM--KDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCF
|.||..| ..|.  ..  .. . ||||||..|..||||.||||||||. ...| ..||..||||.||.| .||..|||.| ..||||.||..||||||..
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KKNDKKPPEEQIVTAMPDVIVKDLT-PDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLApdcqmgGLGCDNMTVIILTF
|.. . ...|..|.|.|||.| .|| .|..||.||.||.||||||.|.||..||.||....||...|||. ..||      . ..||.||... .
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
subfamily_PPM1A_pd Subfamily PPM1A 15-286 9.5e-89 290.5 In-house 5-280 (282) alignment 
Range on Protein: 15-286
Range on HMM: 5-280/282.0
SSCSNKSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAW--------AKGNVIEALKKGFLSCDTDMLK
|. ...... . | |||||..|||||| . ||.. |. .|  |.|||.|..||.|| ..|...| .. ..         | .| |||..|||. | .. .
sqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

DEQMKD--EVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDKKPPEEQI
... ..  . .|.|||.|......|..||.|||||. |..| .. |. |||||...|..|| .||| |  .||||.||.||||||. .|....|..||| 
lstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeql

VTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQmgglgcDNMTVIILTF
|.| |.| . . . ...||||||||||||||..|||...|.|| .  |||.....|. ..|  . .      ||..|....|
vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
PPM_PTC7 23-269 1.5e-87 286.3 In-house 2-255 (259) alignment 
Range on Protein: 23-269
Range on HMM: 2-255/259.0
KLASSCMQGWRINMEDAHTEILSLK---EDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLSCDTDMLKDE--QM-KDEVA
.. .|..||.| .|||||.    |     ... ||..|.||||| ..|.|....| .......   .. ....||.|.||..|||. ..   .. ...  
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE---FNRVNGNLALSRALGDFCFKKNDKkppEEQIVTAMPDV
|.||||..| ..|||.||||||||. |..| .  ||..|||||||.| .|| .|||.|.   ..||||.||.|||.|||..|.. .   ||| |.| ||.
GstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdi

IVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRmELEQICEELLTRCLAPDC
 . ......|||.||.||.|||.|.||.||..||.|... ... ..|.|.. ..|...
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
PP2C Protein phosphatase 2C 23-269 2.6e-85 279.1 Pfam-A 2-251 (255) alignment 
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLScDTDML--KDEQM-KDEVA
.. .|..||.| .|||||. . .|   . ... ||..|.||||| ..|.| ...|......|.   .. .| .||.|.||. |||.   ..... ...  
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskantepsks

GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDkkppeEQIVTAMPDVIV
|.||||..|...|||.||||||||. |.|.  . .|..|||||.|.|..|| .|||.|. ..||||.||.|||||||..|...     ||.|.| ||| .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDC
 .||...|||.||.||.|||||.||.||..||.| .  ......|||.. ..|. .
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PP2C Protein phosphatase 2C 23-269 2.6e-85 279.1 In-house 2-251 (255) alignment 
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLScDTDML--KDEQM-KDEVA
.. .|..||.| .|||||. . .|   . ... ||..|.||||| ..|.| ...|......|.   .. .| .||.|.||. |||.   ..... ...  
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskantepsks

GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDkkppeEQIVTAMPDVIV
|.||||..|...|||.||||||||. |.|.  . .|..|||||.|.|..|| .|||.|. ..||||.||.|||||||..|...     ||.|.| ||| .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDC
 .||...|||.||.||.|||||.||.||..||.| .  ......|||.. ..|. .
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
subfamily_PPM1G_pd Subfamily PPM1G 115-286 9.8e-76 248.6 In-house 296-470 (473) alignment 
Range on Protein: 115-286
Range on HMM: 296-470/473.0
AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDKKPPEEQIVTAMPDVIV
.||||||...|..||. ||.||||.. ...|   .|| |||| .|.|..|| .||| |.   |||| | |||||||...||| . |..||...|.||. |
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv

KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM--ELEQICEELLTRCLAPDCQMGGLGCDNMTVIILTF
. ||...|||||||||||.|.. ||||||.|..|...    |..|.||||  ||||| .  | |||||||||...
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
0049733 PP2C-like 22-285 2e-61 200.1 In-house 3-232 (235) alignment 
Range on Protein: 22-285
Range on HMM: 3-232/235.0
YKLASSCMQGW-RINMEDAHTEilslkedkNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ-PAWAKGNVIEALKKGFLSCDTDMLKDEQM--KDEVAGT
.. . ....|. | ..|||.          ......|.|||||....... ..| . ....  ..   ...|||.| || ... .|.  .   .  . ||
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgt

TAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVefnRVNGNLALSRALGDFCFKkndkkppeeqivtamPDVIVKDLT
||||... ..|||.||||||||. ...| ..||..||.|.||.| .|||.|||.|   ||.| |||.|||||...|               ||| | .|.
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlele

PDHeFLVLACDGIWDVLSNQEVVDFIRSrlaqrMELEQICEELLTRCLApdcqmgGLGCDNMTVIILT
|.. ||.||.||.|||||..|.||..||     ..||...|.|. ..||      . |.||.||... 
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvr
subfamily_PPM1E_pd Subfamily PPM1E 21-284 2e-57 187.4 In-house 3-260 (265) alignment 
Range on Protein: 21-284
Range on HMM: 3-260/265.0
SYKLASSCMQGWRINMEDAHTEILS------LKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNViEALKKGFLSCDTDMLKDEQMKDEV
.|.. . .... |  ||| |  . .      ||..|..||..|.|||||   |.|  ..|.. ...|.   .  . ||||..|  .|. .|.  . .   
eyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklk

AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWV---EFNRVNGNLALSRALGDfcfkkndkkPPEEQIVTAMPDV
.|.|||||.|....|| | .|||.|. ..|| . ||   |||..|.| .|| .||| |   .  ||||.|..|||.||         . ... |.. .||
sGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGD.........vklkpyvsgeadv

IVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM-ELEQICEELLTRCLAPDCQmgglgcDNMTVIIL
   .|. ..|.|.|||||.|||. ..|||. ... ||.   .|... ..|..     . .      ||.||.. 
aeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 20-262 1.2e-51 168.5 In-house 4-235 (255) alignment 
Range on Protein: 20-262
Range on HMM: 4-235/255.0
KSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDMlkdeQMKDEVAGTTA
. .|.. | | | |  |||  .   | .....  .. ..||||| . |..  ..|.| .|.     . | ...||| . . .| .    . .    ||||
srfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGtta

VVVVIKNNKLYCANVGDSRAIAC-KKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN----RVNGNLALSRALGDFCFKkndkkPpeeqIVTAMPDVI-V
..|.| ..| | |||||||.. | |.|  ..||.|||||.|.|..|| ..|| |  .    ||||.||.||||||  ..     |     |.. ||.   
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P....fvvpdPdlsqs

KDLTPDHEFLVLACDGIWDVLSNQEVVDFIrsrlAQRMELEQICEELLT
 . . ...||.||||||||..|..| |. .    |.  . |. .|.|  
leiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrd
subfamily_PPM1L_pd Subfamily PPM1L 23-249 7.6e-50 162.6 In-house 6-238 (269) alignment 
Range on Protein: 23-249
Range on HMM: 6-238/269.0
KLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQP---AWAKGNVI-----EALKKGFLSCDTDMLKDEQMKDEV
. |  ...| | .|||  .    .|.. .. |..|.|||||   |... . | |.| ..    . .| | .     . |..  || |...|.  . . ..
qvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi

AGTTAVVVVIKNNKLYCANVGDSRAIAC-KKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN---RVNGNLALSRALGDFCFKkndkkppEEQIVTAMPD
|||||.. ......|  ||||||| . . |.|    ||||||| . .| .||  |||.. |.   ||.| || ||||||. .|       ....| | ||
aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadpd

VIVKDLTP-DHEFLVLACDGIWDVLSNQEVVDFIRSRLAQ
..  ||   . |||.||.||.|| .||.| | ||. || .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
PPM_PTC7_SpoIIE 23-266 2.8e-48 157.7 In-house 2-223 (230) alignment 
Range on Protein: 23-266
Range on HMM: 2-223/230.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARvaQYVGQNLQKKIASQPaWAKGN-VIEALKKGFLSCDTDMLKDeqmkDEVAGTT
.. .|..||.| .|||||.    .    ..   ...|..|||||    ...   | ......   | .. . |.|....| ...|. ..    ... |.|
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaT

AVVVVIKNNK--LYCANVGDSRAIACKK--GlveqlsfdhkpsneeETRRIiAAGGWVE----FNRVNGNLALSRALGDFCFKKndkkppEEQIVTAMPD
|||..| ...  ||.||.|||... ...  |               | .|| .|||...    ..||.|.||.|.| ||. ..       ....|.| ||
avvalidpstgklyvanaGdsppllvrddgg...............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd

vIVKDLT-PDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRmeleqICEELLTRCLA
  . ...  ..|||.||.||.|||||.||.||..|..| .      ..|.||. ...
.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit
subfamily_ILKAP_pd Subfamily ILKAP 26-257 5.9e-43 140.1 In-house 9-253 (293) alignment 
Range on Protein: 26-257
Range on HMM: 9-253/293.0
SSCMQGWRINMEDAHTEILSLKED--------KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAW----A-KGNVIEALKKGFLSCDTDMLKDEQMKD
 .. .| | .|.|||. . .|.|.        .. .. .|.|||.| | .... ..|.||| .. .     | . ..  .| . |   | ..||  . . 
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskak

EV--AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQ------LSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDkkppeeqi
 |   |.||.||.. .| || ||.|||.|. ..|    .      |. ||.| ..|| .||  ||| |. .||.| |  ||..||  ||.          
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG........

VTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQIC
|.. |||   .||..  |.||||||.|.|.|..|||.|| . | .. . ..| 
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkik
subfamily_PPM1K_pd Subfamily PPM1K 28-247 1.1e-38 125.9 In-house 10-229 (263) alignment 
Range on Protein: 28-247
Range on HMM: 10-229/263.0
CMQGWRINMEDAhTEILSLkeDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPaWAKGNVIEALKKGFLSCDTDMLKDEQMK-----DEVAGTTAVVV
 ..| | . ||   ... |  |..  ...|.|||.|.  |..| ..|.| .         .. . ||. |. .|... .  ...      . .|||| |.
sliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvs

VIKN-NKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN-----RVNGNLALSRALGDFCFKKNDkkppeeqiVTAMPDVIVKDL
.... ..|  |..|||||| |..|  ..|. ||.|. ||| .|| |||| ||.|     .||| ||..|.|||. .|.          | | |.    ..
llrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........viatPetkslkv

-TPDHEFLVLACDGIWDVLSNQEVVDFIRSRL
   .  ||||  ||| .|...||. |..|   
dhaadsflvlitdgisfvvnsqelcdlvrlch
subfamily_PPM1D_pd Subfamily PPM1D 24-174 1.5e-30 99.3 In-house 4-173 (309) alignment 
Range on Protein: 24-174
Range on HMM: 4-173/309.0
LASSCMQGWRINMEDAHTEILSLKED---KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWA---KGNVIEALKKGFLSCDTDMLKDEQ-------M
..|.. || |  |||  .  |. .|    .. ||..|.|||||   |... ..| ..|  |  .    . .|.||....||.. . | |  .        
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

KDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGL------VEQLSFDHKPSNEEETRRIIAAGGWVEF
.   ||||| ||.|...||| |.||||...  .|         ..|  ||||.. ||..||  .|| |  
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_PPM1G_pd Subfamily PPM1G 5-112 1.7e-30 99.4 In-house 2-107 (473) alignment 
Range on Protein: 5-112
Range on HMM: 2-107/473.0
LSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTEILSLkeDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDM
||.| . ||..  ||.. . . | ||||| ..||||..|. |  |..|....|||||||. ||.|| ..| . .  | ....|.| .||.. ||..|. .
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

LKDEQMKD
 ..|..|.
kaeeslke
subfamily_KAPP-like_pd Subfamily KAPP-like 31-285 4.6e-28 91.0 In-house 7-265 (266) alignment 
Range on Protein: 31-285
Range on HMM: 7-265/266.0
GWRINMEDAHTEILSLKEDKN------TAFLGVYDGHGGARVAQ----YVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDMlkDEQM-KDEVAGTTA
|  ..||| .  |  | ..|.       |...|.||| |  .|.     . ..|.|.. |      |. |   .| ..    ..  |... . |  |.||
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkev..daklkdfeyeGata

VVVVIKN----NKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEF--NRVNGnLALSRALGDFCFKKNDKKPPEEQIVTAMpdviv
 .... .      | .|||||| |. ..     .||.|||  ..|| .||   |  .     |.|| ||.||||||   |. .     |  |.       
tlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnr.....

KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLtrclapDCQMG-GLGCDNMTVIILT
  ||| ..||..| ||.|||.| .. .. ..|   |.   ..... ||      .. ..  .  ||..||...
illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassll......etaiqsikakdnvsvivvk
subfamily_PDP_pd Subfamily PDP 88-256 6.8e-27 87.6 In-house 114-321 (398) alignment 
Range on Protein: 88-256
Range on HMM: 114-321/398.0
NVIEALKKGFLSCDTDMLKDEQ-----------MKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKK---G--LVEQLSFDHKPSNEEETRRIIAAGG-
.| |||||.||..| |. .. .           ..  ..|..|....|....|. ||.||.||. ...   |   . .|| |.  .|||| .|| ..   
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPg

-----WVEFNRVNGNLALSRALGDFCFKKND---KKPPEE--------------QIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLA
      .  .|. |.|. .|| ||. .| .    ||. |.                .|| |.|. . |...  ||||| ||.||.|||.|||. .   ||
eesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehla

QRMELEQI
...| |..
kkkekepv
subfamily_TAB1_pd Subfamily TAB1 110-237 9.4e-25 80.1 In-house 123-263 (333) alignment 
Range on Protein: 110-237
Range on HMM: 123-263/333.0
MKDEV-AGTTAVVVVIKNNKLYCANVGDSRAIACK---KGLVEQLSFDHKPSNEEETRRIIAAG---GWVEFNRVNGNLALSRALGDFCFKKNDK-----
...|.  ||||||..| ||||| ||||||||...|   .  |.||| ||.  ||.|  |.   |     .. |.. |.    |..||.. ||  |     
leeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdil

KPPEEQIVTAMPDVIVK-DLTPDHEFLVLACDGIWDVLSNQ
.  ... | | ||..   ....   ||||  ||.   | . 
ssakgePviaePdiqgaypiddityflvlmSdGvyktLeev
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-285 2.6e-24 78.5 In-house 6-275 (276) alignment 
Range on Protein: 31-285
Range on HMM: 6-275/276.0
GWRINMEDAHTEILSLKEDKN------TAFLGVYDGHGGARVAQ----YVGQNLQKKIAS-----QPAWAKGNVIEALKKGFLSCDTDMlkDEQMKD-EV
|  ..||| .  |  | ..|.       |...|.||| |  .|.       ..|.| . |           |. |   .| .|    ..  |...|| | 
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkev..daklkdfey

AGTTAVVVVIKNNK----------LYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEF--NRVNGnLALSRALGDFCFKKNDKKPPEE
 |.|| .... ..           | .|||||| |. ..     .||.||| .. || .||   |  .     |.|| ||.||||||   |. .     |
eGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise

QIVTAMpdvivKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLtrclapDCQMG-GLGCDNMTVIILT
  |.         ||| ..||..| ||.|||.| .. .. ..|   |.   ..... ||      .. ..  .  ||..||...
pyvsnr.....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassll......etaiqsikakdnvsvivvk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 49-192 2.1e-22 73.0 In-house 17-185 (292) alignment 
Range on Protein: 49-192
Range on HMM: 17-185/292.0
DKNTAF-LGVYDGHG--GARVAQYVGQNLQKKIASQPAwAKGNVIEALKKGFLSCDTDMLKDEQMKDEVAGTTAVVVVIKNN-KLYCANVGDSRAIACK-
 .  .|   |.||||  | .|||.  ..|.... .     . .. ||| .. |.  . . |    . | |.|..|  ..... .|. ||||||||.  . 
sealtflaavldGhGvnGdkvaqlaedtlevelleltr.qlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrc

----KGLVEQLSFDHKPSNEEETRRIIAAGGWVE-----------FNRV------NGNLALSRALGDFCF
    .  .  || ||||.. .| .|| .||| ||             ||      .|.|||||||||| .
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_PP2D1_pd Subfamily PP2D1 117-252 3.6e-21 68.4 In-house 178-314 (492) alignment 
Range on Protein: 117-252
Range on HMM: 178-314/492.0
TTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVE----FNRVNGNLALSRALGDFCfkkndkKPPEEQIVTAMPDVI
 .  |  ..   || ||.|. .|. |..|   .|  .| | |..| .|.  ||. |       .||| |   | || .        |  .. |   | ..
ngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG......dpkLkksvipePktt

VKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM---E
   |.    |||||  |.|.|||..||.  ... ||.     .
svkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvr
PPM_PTC7_motif 224-269 3.7e-17 55.6 In-house 1-47 (51) alignment 
Range on Protein: 224-269
Range on HMM: 1-47/51.0
VLACDGIWDVLSNQEVVDFIRSRLA-QRMELEQICEELLTRCLAPDC
.||.||.|||||.||.||..|..|. .. ......|.| ...||. .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs
subfamily_PPM1H_pd Subfamily PPM1H 89-162 5.2e-17 54.7 In-house 136-209 (404) alignment 
Range on Protein: 89-162
Range on HMM: 136-209/404.0
VIEALKKGFLSCDTDMLKDEQMKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEET
|| || . ||..|  . ....      | ||.|... ..||| || |||||| ..|. . .||.|. |  | . 
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqR
subfamily_PPM1D_pd Subfamily PPM1D 181-286 1.2e-14 47.1 In-house 201-307 (309) alignment 
Range on Protein: 181-286
Range on HMM: 201-307/309.0
LALSRALGDFCFKKNDKkppEEQIVTAMPDVIVKDLTPDHE-FLVLACDGIWDVLSNQEVVDFIRSRLAQRMEL----EQICEELLTRCLApDCQMGGLG
||..|.|||.   .. .   .| .|   ||| |. |.|..| |..|| ||.|.||. ...|.....  ....      ... . |... |    .   | 
LavaRslGDlWsynaks...gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskklr

CDNMTVIILTF
.||..||....
aDnvsvivvil
PP2C_SIG_SM00331 49-285 2.1e-13 43.3 In-house 26-216 (217) alignment 
Range on Protein: 49-285
Range on HMM: 26-216/217.0
DKN-TAFLGVYDGHG----GARVAQYVGQNLQKKIASQpawakgnviEALKKGFLSCDTDMLKDeqMKDEVAGTTAVVVVI--KNNKLYCANVGDSRAIA
... . .| | ||.|    .| ..  . . |.. . ..         |.|.. .  ..  . .    ...  ..|... ..  ...||. ||.|||| . 
lnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyl

CK-KGLVEQLSFdhkpsneeetrriiaaggwvefnrvngnlalsralgdfcfkknDKKPPEEQIVTAMPDVIVKDLTPdHEFLVLACDGIWDVL-----S
   ..|||.|..                                            . .|   ... ..|.   .| .  ..|.|. ||....       
lrdgklveilkd...........................................vegaplGlepevsvdirelelek.gdllllytDGltearsekgfa

NQEVVDFIRSRLaqRMELEQICE----ELLTRCLAPDCqmgglgCDNMTVIILT
.... ..... .   .|.... .    |||..  ..         |..||... 
eerleeiledlv..dseaqelaqkiveellelakgsng......eDdiTvvvvk
subfamily_PHLPP_pd Subfamily PHLPP 50-245 6.4e-12 37.9 In-house 25-214 (246) alignment 
Range on Protein: 50-245
Range on HMM: 25-214/246.0
KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQpAWAKGNVIEALKKGFLSCDTDMLKDeqmkDEVAGTTAVVVVIKNNK--------LYCANVGDSRAIA
.. |  |..||.    ... . . ... .. .    . |. | .|. .| .  .. ..     |  |..|... |...|        |  |.||   |. 
svealyGlfdGdrneelssllqrlmkdvlkee.vqkdkneeeymkntllvaqrklGea....GeklgsaallilirhdkvdPaksfsLevAsvGtlqavl

CKKGLVEQLSFDHKPSNEeETRRIIAAGGWV-EFNRVNGNLALSRALGDFCFKkndkkPpeeqIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVV
...|   .||  .. ... | .||  | . . | |..|| .. .| || .        |    .|   | |    ||.. |.|..  . .|.||| .|.|
iRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflf.....P....vvlPkphvrevlLteqdellivGnkalWevlsideav

DFIRS
. .| 
eavrk
subfamily_PPM1H_pd Subfamily PPM1H 175-250 1.1e-10 33.9 In-house 275-354 (404) alignment 
Range on Protein: 175-250
Range on HMM: 275-354/404.0
NRVNGNLALSRALGDFCFKKNDKKPPEEQIVTAMPDVIVKDLTP----DHEFLVLACDGIWDVLSNQEVVDFIRSRLAQR
.|. . .. .| |||   |  |..     .....|.| | |||     . . |.|| ||.||||||.||   .|. |.. 
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
PP2C_2 Protein phosphatase 2C 46-248 8.6e-10 31.3 Pfam-A 18-196 (212) alignment 
Range on Protein: 46-248
Range on HMM: 18-196/212.0
LKEDKNTAFLGVYDGHGGARV--------AQYVGQNLQKKIASQPAWAKGNVIEALKKGFLS-C---DTDMLKdeQMKDEVAGTTAVVVVIKNNKLYCAN
 .|...  .| | ||.| |.         .. .|. |.|..... . ..  ........ |  .   .  . .  |.. .  .|| ...||.........
ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffq

VGDSRA-IACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFnrvngnlalsralgdfcfkkndkkppeeqivtampdvIVKDL-TPDHEFLVLACDGIW
.||... .  . | |..|. ...   . ||...  .  . |.                                      .. | ... . |.|  ||..
iGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlklepgdalllmTDGvs

DVLSNQE-VVDFIRSRLA
| |...| . .... .|.
dslrkeepfrellaelle
PP2C_2 Protein phosphatase 2C 46-248 8.6e-10 31.3 In-house 18-196 (212) alignment 
Range on Protein: 46-248
Range on HMM: 18-196/212.0
LKEDKNTAFLGVYDGHGGARV--------AQYVGQNLQKKIASQPAWAKGNVIEALKKGFLS-C---DTDMLKdeQMKDEVAGTTAVVVVIKNNKLYCAN
 .|...  .| | ||.| |.         .. .|. |.|..... . ..  ........ |  .   .  . .  |.. .  .|| ...||.........
ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffq

VGDSRA-IACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFnrvngnlalsralgdfcfkkndkkppeeqivtampdvIVKDL-TPDHEFLVLACDGIW
.||... .  . | |..|. ...   . ||...  .  . |.                                      .. | ... . |.|  ||..
iGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlklepgdalllmTDGvs

DVLSNQE-VVDFIRSRLA
| |...| . .... .|.
dslrkeepfrellaelle
PPM_PTC7_SpoIIE_motif 221-285 1.5e-09 31.4 In-house 13-79 (81) alignment 
Range on Protein: 221-285
Range on HMM: 13-79/81.0
EFLVLACDGIW-------DVLSNQEVVDFIRSRlaQRMELEQICEELLTRCLApdcQMGGLGCDNMTVIILT
. |.|..||..       ......|........  . ..|......|. ..|.   . .|   |..|...| 
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlr
Subfamily Dicty-PPM1L-like 28-76 4.1e-09 28.7 In-house 13-61 (305) alignment 
Range on Protein: 28-76
Range on HMM: 13-61/305.0
CMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQK
  .. | . || .   .||.....  ..||.|||.| . |.|| ..| .
vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklve
subfamily_PP2D1_pd Subfamily PP2D1 32-81 2.7e-08 26.0 In-house 13-62 (492) alignment 
Range on Protein: 32-81
Range on HMM: 13-62/492.0
WRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ
|. .|||..|      .| |..|.|.|||. ||  |.   ..|.. ....
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevllee
Subfamily Dicty-PPM1L-like 176-285 5.2e-08 25.1 In-house 200-302 (305) alignment 
Range on Protein: 176-285
Range on HMM: 200-302/305.0
RVNGNLALSRALGDFCFKKNDKkPPEEQIVTampdVIVKdltPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQI---CEElLTRCLAPDCQMG
.||. |  ||  ||   |.    |.... .     |. |   .. .||||| ||.|.|||.|.||....  | ...  ..|    .| . |  .      
lvnrllkksrskGdknlkelvi.Pnndspll....vvak...anDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne.isrviveeavkr

GLGcDNMTVIILT
| | ||.|..|. 
gsg.Dnitlviik
Subfamily Dicty-PPM1L-like 117-189 8.8e-07 21.0 In-house 216-294 (305) alignment 
Range on Protein: 117-189
Range on HMM: 216-294/305.0
TTAVVVVIKNNK-LYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGG---W--VEFNRVNGNLALSRALGD
.. .|.  .... |  |. .|.. . .. || | ||..... . .|  |.   ..   |   |  || ...|..|  ||
lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 211-245 9.8e-07 21.6 In-house 238-272 (292) alignment 
Range on Protein: 211-245
Range on HMM: 238-272/292.0
VIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRS
 . |.|  | .||||| ||. |||.|.||| ..  
klekeldsddaflvlasdGvldvllnaevvlllak
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 116-270 1.6e-06 19.6 In-house 135-305 (317) alignment 
Range on Protein: 116-270
Range on HMM: 135-305/317.0
GTTAVV-VVIKNNKLYCANVGDSRAIAC---------KKGL-VEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLAL-SRALGDFCF---KKNDKKPP
|||||| ||. . .. .|| ||. |.           . || || ||  |.   ..|  |.  . .       .| ||    || ..     |   .|  
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkll

EEQIVTAMPDVIVKDLTPDHEFLVLAC-DGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQ
.   |.| |.| .. |  |  | |... ||| | |....|.| .    . .   |..|..    .|. .. 
kraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsi
subfamily_PDP_pd Subfamily PDP 36-81 2.7e-06 19.8 In-house 11-54 (398) alignment 
Range on Protein: 36-81
Range on HMM: 11-54/398.0
MEDAHTEILSLKEDknTAFLGVYDGHGGARVAQYVGQNLQKKIASQ
.|| ..|  .|...    ..|| ||||||  |. | ..| | .| .
iEDrrseakllesn..gvlfgvfDGHggaacaeavskrLlkyvaas