Gene PTC3 in Saccharomyces cerevisiae

Synonym: YBL056W, PTC3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP002_AA protein Get Run
ScerP002_AA_2-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 4-294 3.9e-134 439.1 In-house 1-287 (287) alignment 
Range on Protein: 4-294
Range on HMM: 1-287/287.0
ILSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLEQCLIDTFLAT
.||.|...||..|....||..| .||||.|..||||||.|..||..||...||....||||||..||...|.|.|....|..|||.|.|||.|.|.||.|
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DVELLKDEKLKDDHSGCTATVILVSQLKklLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNTKL
| ||||||||||...|.||.|.|... |  |..||.||||.|||. ||.||.||||||.  |||.||.||.||||..|||||||||||.||||||.|.|.
DeellkdeklkdesaGstavvvlikeek..lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

GPHEQVVTCVPDIICHNLNyDEDEFVILACDGIWDCLTSQECVDLVHYGISQGnMTLSDISSRIVDVCCSPTTEGSGIGCDNMSISIVALL
.|.||.||.|||.....|. ..|||..||||||||.||..|.||||.. ...| ..|..|.....| |..|... .|.|||||.. ||.||
kpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvll
PP2C Protein phosphatase 2C 24-277 3e-87 285.4 Pfam-A 3-252 (255) alignment 
Range on Protein: 24-277
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSG-MLEQCLIDTFLA-TDVELLKDEKL-KDDHSGC
.| ...||.|.||||||| ..|| ..|.... ||...||||||. .|.......  |||.|.||...  .|..|...||| || || ....  ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATVILVSQLKklLICANSGDSRTVLSTGGNSK-AMSFDHKPTLLSEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNTklgphEQVVTCVPDIIC
||.|.|... |  |..|| ||||.||....|.| ....||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||.  
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HNLNYDeDEFVILACDGIWDCLTSQECVDLVHYGISQGNmTLSDISSRIVDVCCSPTTE
..|... |||.|||.||.||.|..||.||||.. .|... ...... ..|| .... .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 24-277 3e-87 285.4 In-house 3-252 (255) alignment 
Range on Protein: 24-277
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSG-MLEQCLIDTFLA-TDVELLKDEKL-KDDHSGC
.| ...||.|.||||||| ..|| ..|.... ||...||||||. .|.......  |||.|.||...  .|..|...||| || || ....  ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATVILVSQLKklLICANSGDSRTVLSTGGNSK-AMSFDHKPTLLSEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNTklgphEQVVTCVPDIIC
||.|.|... |  |..|| ||||.||....|.| ....||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||.  
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HNLNYDeDEFVILACDGIWDCLTSQECVDLVHYGISQGNmTLSDISSRIVDVCCSPTTE
..|... |||.|||.||.||.|..||.||||.. .|... ...... ..|| .... .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargse
PPM_PTC7 24-277 8.2e-87 283.9 In-house 3-256 (259) alignment 
Range on Protein: 24-277
Range on HMM: 3-256/259.0
FGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSG-MLEQCLIDTFLA--TDVELLKDEKL-KDDHSG
.| .|.||.|.|||||||...|| ..|.... ||...||||||. .|.......  |||...||...  ||..|...|||  || || ..|.  ....||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

CTATVILVSQLKklLICANSGDSRTVLSTGGNSK-AMSFDHKPTLLSEKSRIVAADGFVE---MDRVNGNLALSRAIGDFEFKSNTKlgpHEQVVTCVPD
.||.|.|... |  |..|| ||||.||...||.. ....||||.. .|..|| .|.|.|.   . ||||.||.|||.||||.|.. .   .||.|.. ||
stAvvalitgsk..lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePd

IICHNLNYDeDEFVILACDGIWDCLTSQECVDLVHYGISQGnmTLSDISSRIVDVCCSPTTE
|  ...... |||.|||.||.||....||.||||.. .|..  ...... ..|| .... .|
isstkidee.defliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargse
0034914 PP2C-like 3-293 1.9e-77 252.8 In-house 2-290 (295) alignment 
Range on Protein: 3-293
Range on HMM: 2-290/295.0
QILSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLAESDeeHLAFYGIFDGHGGSSVAEFCGSKMISILKKQ-------ESFKSGMLEQC
..||.|.... ..|   .|. .| . .||.|.|.|||..| .|||   .  .|...|.||||||...||.. . ....|...        .. . ..|..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieea

LIDTFLATDVELLKDEKL--KDDHSGCTATVILVsqLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIG
|...|||.| |||.   |  ....||.||.|.|.   .. |..|| |||| ||...|  . ...||||.  .|. ||..|.|.| ..||||.||..||.|
lrkaflaadeellelallrpelagsGtTavvali..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalG

DFEFKSNTKLGPHEQVVTCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISqGNMTLSDISSRIVDVCCSpttegsGIGCDNMSISIVAL
||..| . .| ..|..|...||.....|....|.|..||.||.||.|...|.||.|.  .. ....|.... ..|| . .      . ..||... .| |
dfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
PP2Cc_SM00332 21-291 1.1e-76 250.8 In-house 9-274 (274) alignment 
Range on Protein: 21-291
Range on HMM: 9-274/274.0
LTAFGLCAMQGWRMSMEDAHIVEPNLLaesDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSG----MLEQCLIDTFLATDVELLKDEKLKDD
  ..|...||||| ||||||.| ..|     ||  .|.|.|||||||.||.|. .|. ..||.. ..|..    . |..| . ||.|| |.|..|. | .
glsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

---HSGCTATVILVSQLKklLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNTklGPHEQVVTCV
    ||.||.|.|... .  |..|| |||| ||...|.....| ||||   .|..|| .| |.|| .||||.||.|||.||...| |   .. |...|. 
enalsGstavvallkked..lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitae

PDIICHNLnYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNMTLSDISSRIVDVCCSPTtegsGIGCDNMSISIV
||. ...|  .||||.|||.||.||.|..|| ||.|.  ...|.    .  .  .| .....    | ..||... .|
pdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 16-293 1.2e-73 240.9 In-house 6-280 (282) alignment 
Range on Protein: 16-293
Range on HMM: 6-280/282.0
SGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLaesDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFK--------SGMLEQCLIDTFLATDVEL
.. .    .|. .|||||..|||||.|  .|      .. .|. .||||.||.||... ..... . ..|..|        .  ... | . |||.| ..
qaegnglrygvssmqgwrvemEDahtvvaslg...alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeai

LKDEKLKD--DHSGCTATVILVSqlKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNTKLGP
 .... ..  |.||.||...|||  .| ||.|| ||||.||. .|... .. ||||.  .|| || .|.|.| ..||||.||.|||.||.|.|.......
relstdlktadksGsTavtvlvs..ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekka

HEQVVTCVPDIICHNLNYDEDeFVILACDGIWDCLTSQECVDLVHYGISQGnMTLSDISSRIVDVCCSpttEGSGigcDNMSISIVAL
.|| |. .|.. . . . ..| |..|||||||| |...| |.||.  ....   |. .....|| . .   .||.   ||.|. .|..
eeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkale...kgsr...DNlsvlvvlf
subfamily_PPM1G_pd Subfamily PPM1G 117-293 2.2e-60 198.0 In-house 295-470 (473) alignment 
Range on Protein: 117-293
Range on HMM: 295-470/473.0
HSGCTATVILVSqlKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMD-RVNGNLALSRAIGDFEFKSNTKLGPHEQVVTCVPD
 ||.||.|.|.   .| || || ||||.|||  |.   .| ||||    |..|| .| | |..| |||| | ||||.||. .|.|..|...||... .||
dsGttAvvaLlk..ekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPD

IICHNLNyDEDEFVILACDGIWDCLTSQECVDLVHYGISQGN-MTLSDISSRIVDVCCSPTTEGSGIGCDNMSISIVAL
|  . |  .||||..|||||||....||| || |.  ...|.  .||.|  ...| | .| |.| | |||||.. || |
ikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
0049733 PP2C-like 24-292 2.1e-48 157.6 In-house 5-232 (235) alignment 
Range on Protein: 24-292
Range on HMM: 5-232/235.0
FGLCAMQGW-RMSMEDAHIVepnllaesdeeHLAFYGIFDGHGGSSVAEFCGSKMISILKKQ-ESFKSGMLEQCLIDTFLATDVELLKDEKLK--DDHSG
.| . ..|. |  .|||..|           .|......|||||. ..|.. . ....|... ... .  ||..|...|||.. .||.  .     ...|
vgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

CTATVILVSqlKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVemdRVNGNLALSRAIGDFEFKsntklgpheqvvtcvPDIICH
.||.|.|.   .. |..|| |||| .| ..|.   ...||.|.   |. ||..|.|.|   ||.| |||.||.||...|               ||. ..
tTavvalld..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvl

NLNYDEdeFVILACDGIWDCLTSQECVDLVHYgisqgnMTLSDISSRIVDVCCSpttegsGIGCDNMSISIVA
.|. ..  |..||.||.||.|...| |||..       ..|... .|.|. ...      . |.||... .| 
elepgd..flllasDGlwdvlsdeeivdllrs......ldleeaaerlvelala......rggrDNiTvvvvr
PPM_PTC7_SpoIIE 24-263 3e-48 157.6 In-house 3-213 (230) alignment 
Range on Protein: 24-263
Range on HMM: 3-213/230.0
FGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSvaEFCGSKMISILKKQEsFKSGM-LEQCLIDTFLA--TDVELLkdeklkDDHSGC
.| .|.||.| |||||||...|. ..|..   ...|..|||||..   .. . . ..|...  |...  .|..|....||  .| |        ...||.
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede......psssga

TATVILVSQLKKLLICANSGDSRTVLSTGgNSKamsfdhkptllsEKSRIvAADGFVE----MDRVNGNLALSRAIGDFEFKSntklgpHEQVVTCVPDi
||.|.|.   .  | .|| |||. .|... . .            |. || .| |...     .||.|.||.|.|.||. ..        ..||.. || 
TavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.

ICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGnmtlsdI
  ... ...|||.|||.||.||.|..||.|||| . ...       .
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......a
subfamily_PPM1E_pd Subfamily PPM1E 26-293 2.5e-45 147.7 In-house 8-262 (265) alignment 
Range on Protein: 26-293
Range on HMM: 8-262/265.0
LCAMQGWRMSMEDAHIVEPN---LLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLeQCLIDTFLATDVELLKDEKLKDDHSGCTA
. |... |  ||| |.. ..   |.  .||.. ||...||||||.  |..  ... . | .||..|.  . . | ..| .|| ..|.  . .  .||.||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklksGsta

TVILVSQLKklLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFV---EMDRVNGNLALSRAIGDFEfksntklgpHEQVVTCVPDIICH
 |.|... .  |  |  |||...|   |.   .   |||    ||.|| .|.|.|   .. ||||.|..|||||| .         ... |.  .|.   
vvvliekdq..lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvk.........lkpyvsgeadvaev

NLNyDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNMTLSDISSRIVDVCcspTTEGSGigcDNMSISIVAL
.|. ...|..||||||.|| .. .| |.||.  ...|...||...  .|.     . .||    ||... .| |
eld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaa...keagss...Dnitvvvvfl
subfamily_PPM1L_pd Subfamily PPM1L 27-250 1.4e-42 138.8 In-house 10-233 (269) alignment 
Range on Protein: 27-250
Range on HMM: 10-233/269.0
CAMQGWRMSMEDAHIVEPNLlaeSDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQ----ESFKSGM----LEQCLIDTFLATDVELLKDEKLKDDHS
 ...| |  |||  ..| ..   ... .  |...||||||   |||. ...   .|..    .. |        .. | |  |. | .||.  | . | .
ysvlGrrprmedrfeieedi...knktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedia

GCTATVILVSQLKklLICANSGDSRTVLS-TGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMD---RVNGNLALSRAIGDFEFKSntklgphEQVVTCVP
|.|| . ||.. .  || || |||| ||  . |..  .||||||  . |. ||  | ||. ..   ||.| || |||.||. .|        ...|   |
Gttalialvqesd..livanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadp

DIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVH
||.. .|.  . ||.|||.||.||... .| |  ..
diltfdlddhkpeflilasdGlwdtfsneeavrfik
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 25-255 3.4e-42 137.5 In-house 9-225 (255) alignment 
Range on Protein: 25-255
Range on HMM: 9-225/255.0
GLCAMQGWRMSMEDAHIVEPNLLAESDEEHlafYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLEQCLIDTFLATDVELlkdeKLKDDHSGCTATV
| . | | | .|||  ..  .   .|||..   | .||||||.. |.|.  ..  ||..    ..   ...| ... .... .    . .  . |.||..
gfsdmiGrrptmedelviyGsfrdksdedy...yalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaas

ILVSQlkKLLICANSGDSRTVLS-TGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMD----RVNGNLALSRAIGDFeFksntkLGPHeqvVTCVPDIICH
.|. .  .  . || |||| ||.   | .| .|.||||.  ||. || .. |.|  .    ||||.||.|||.||  |     | |.   |.  ||.   
vliie..dkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f.....lePf...vvpdPdlsqs

NLNYDEDEFVILACDGIWDCLTSQECVDLVHyGISQ
. .. .|.|.||||||||| .. .| |..|  |||.
leiskkdkflilacdGiwdlisdeeaveiva.gisd
subfamily_ILKAP_pd Subfamily ILKAP 29-250 1.3e-40 132.4 In-house 12-240 (293) alignment 
Range on Protein: 29-250
Range on HMM: 12-240/293.0
MQGWRMSMEDAHIVEPNLLAESD-----EEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQ---ESFKS--GMLEQCLIDTFLATDVELLKDEKLKDD--
 .| |  |.|||..  .|  ..       .....|..||||.||  .||. .|.   ....   .....    . .||.|.| .|| |.||  . .    
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvW

HSGCTATVILVsqLKKLLICANSGDSRTVLSTGGNS------KAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSntkLGpheqvV
  |.||||.||  | ..|  || |||..||    ..       ... ||.|. . |. ||  | |.|. .||.| |  ||.||| .||.   ||     |
kdGstatvvlv..ldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....v

TCVPDIICHNLNYDeDEFVILACDGIWDCLTSQECVDLVH
...||.   .|. . | ||.|||||.|. .. .| |. . 
istPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfil
subfamily_PPM1K_pd Subfamily PPM1K 48-251 4e-35 114.2 In-house 25-227 (263) alignment 
Range on Protein: 48-251
Range on HMM: 25-227/263.0
AESDeEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQEsFKSGMLEQCLIDTFLATDVELLKDEKLK-----DDHSGCTATVILVSQLKKLLIcANSGDS
.| | ..| ....||||.||. |.|. .|.  |||.    |   ||. | ..|.  | .| .  ...        || |||| |. . ..| . |. |||
keld.pellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvl.aslGds

RTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEM-----DRVNGNLALSRAIGDFEFKSNTklgpheqvVTCVPDIICHNLNYDEDEFVILACDGIW
|..|   |..| .. ||.| |  || || ||.|.||.      .||| ||..|..||...|.          |   |.    ......| |..|  ||| 
railcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........viatPetkslkvdhaadsflvlitdgis

DCLTSQECVDLVHY
. ..|||  |||. 
fvvnsqelcdlvrl
subfamily_PPM1D_pd Subfamily PPM1D 28-293 1.6e-31 102.6 In-house 8-307 (309) alignment 
Range on Protein: 28-293
Range on HMM: 8-307/309.0
AMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGM---LEQCLIDTFLATDVELLKDEK-----LKDD--H
| || |  |||   .  .   .. | . || ..||||||   |.|  ....| .|||. | |     . . . ..||||  .. |  .      . .   
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllst

SGCTATVILVSQLKklLICANSGDSRTVLSTGGN------SKAMSFDHKPTLLSEKSRIVAADGFVEMD----RV---------NGN--------LALSR
.| ||.|... . |  |  |. |||..||..  .      .| .  ||||  ..|| ||  . | | .     ||         ||.        ||..|
aGttasvviirrek..lyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaR

AIGDFeFKSNTKLgpHEQVVTCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNM---TLSDISSRIVDVCCSpTTEGSGIGCDNMS
..||. .  |.|   .| ||  .||.  ..|. .|..|.||| ||.|..||... |..|.   ... .   . .......|.   . ...   . .||.|
slGDl.Wsynaks..gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskklraDnvs

ISIVAL
. .| |
vivvil
subfamily_PPM1G_pd Subfamily PPM1G 5-115 8.8e-30 97.1 In-house 2-107 (473) alignment 
Range on Protein: 5-115
Range on HMM: 2-107/473.0
LSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLlaesdEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLEQCLIDTFLATD
||.|...||.. ..   ...|  |||||| |.|||| . ..|     .|. ......|||||. ||... .|.  .||.|...| | .|..| ..||| |
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl.....dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD

VELLKDEKLKD
 .| ..| ||.
eklkaeeslke
subfamily_KAPP-like_pd Subfamily KAPP-like 31-293 5.8e-26 84.1 In-house 7-266 (266) alignment 
Range on Protein: 31-293
Range on HMM: 7-266/266.0
GWRMSMEDAHIVEPNLLAESD---EEHLAFYGIFDGHGGSSVAEFCGSKMISILKK-QES--FKSGMLEQCLIDTFLATDVELLkDEKL-KDDHSGCTAT
|  . ||| ..    || | .     ..|....|||| |  .|.     .  .|.|  .|   . |  ..      |   .. . |.|| . .. |.|||
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkev.daklkdfeyeGatat

VILVSQ--LKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKsNTKLGpheqvVTCVPDIIC
. || .   ...| .|| ||| . || | .|  .|.||| .  .|| ||   ||     .  |.|| ||.|||.||   | .  .|     ..  | .  
lalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfik.elniG.....lisepyvsn

HNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNmTLSDISSRIVDvccspTTEGSGIGCDNMSISIVAL
. |    |.|.|.| ||.|| .. .. .. |.    |.. |  ...| ...     |. .|    ||.|. .| |
rilltpfdkflivasdGlwdvisGkdaiekvkslydqqa.tedkmasslle.....taiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-293 6.3e-23 74.0 In-house 6-276 (276) alignment 
Range on Protein: 31-293
Range on HMM: 6-276/276.0
GWRMSMEDAHIVEPNLLAESD---EEHLAFYGIFDGHGGSSVAEFCGSKMISIL-KKQESFKSGMLEQ--CLIDT----FLATDVELLKDEKLKD-DHSG
|  . ||| ..    || | |     ..|....|||| |  .|.     .  .| |  .| .  . .|     .      |  |.    |.|||| .. |
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeG

CTATVILVS--------QLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKsNTKLGpheq
.|||. ||         | .. | .|| ||| . || | .|  .|.||| |  .|| ||   ||     .  |.|| ||.|||.||   | .  .|    
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfik.elniG....

vVTCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNmTLSDISSRIVDvccspTTEGSGIGCDNMSISIVAL
 ..  | .  . |    |.|.|.| ||.|| .. .. .. |.    |.. |  ...| ...     |. .|    ||.|. .| |
.lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqa.tedkmasslle.....taiqsikakdnvsvivvkl
PPM_PTC7_motif 230-278 3.3e-17 55.7 In-house 1-49 (51) alignment 
Range on Protein: 230-278
Range on HMM: 1-49/51.0
ILACDGIWDCLTSQECVDLVHYGISQ-GNmTLSDISSRIVDVCCSPTTEG
|||.||.||.|..||.||||....|. |. ..  .....|| .... .| 
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAeklvdealargseD
subfamily_PDP_pd Subfamily PDP 109-268 3.6e-17 55.5 In-house 143-326 (398) alignment 
Range on Protein: 109-268
Range on HMM: 143-326/398.0
KDEKLKDDHSGCTATVILVSQLKklLICANSGDSRTVLSTGG-----NSKAMSFDHKPTLLSEKSRIVAAD------GFVEMDRVNGNLALSRAIGDFEF
 .|.|.   || .|.. |... .  |  || ||.|.|| .       .....| |.  .  .| .|| ..         .  .|. |.|. .|| ||...
lreallvalsGacallaliegte..lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvry

KSNTKLGP---------HEQV--------VTCVPDIICHNLNyDEDEFVILACDGIWDCLTSQECVDLVHYGIsQGNMTLSDISSRIV
| ...|           . ..        .|  |... |.|.  .| |..|| ||.||.|...| |.||.  . ..... ......  
KwseelqkkvlekaylkvlepkdyktPPYltaePevtshklr.endkFLvlatDGLwdllsneevvslVgehl.akkkekepvkveea
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 52-197 1.9e-16 53.5 In-house 17-185 (292) alignment 
Range on Protein: 52-197
Range on HMM: 17-185/292.0
EEHLAF-YGIFDGHG--GSSVAEFCGSKMISILKKQESfKSGMLEQCLIDTFLATDVELlKDEKLKDDHSGCTATVILVSQLKKLLICANSGDSRTVLST
 | |.|   ..||||  |  ||..  ...   | .    .   | . |.   | .  .| ..  ..   |. ||.|  . .  . || || ||||..|  
sealtflaavldGhGvnGdkvaqlaedtlevelleltr.qlqelsealllrildiaakl.dkltidaresattavvcarvrddralilanvGdsrallgr

--GGN---SKAMSFDHKPTLLSEKSRIVAADGFVE-----------MDRV------NGNLALSRAIGDFEF
  ||.    . .| ||||    |..|| .| |.||             ||      .|.||||||.||| .
clggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_PP2D1_pd Subfamily PP2D1 129-257 3.4e-14 45.4 In-house 185-310 (492) alignment 
Range on Protein: 129-257
Range on HMM: 185-310/492.0
QLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVE----MDRVNGNLALSRAIGdfeFKSNTKLgphEQVVTCVPDIICHNLNyD
. . .|  || |. . ||  .|... .  .| |    |..|.  | . |     . .||| |   | .|   .  ..||   .. | . | ... .|. .
eelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLG...nyGdpkL...kksvipePkttsvkld.e

EDEFVILACDGIWDCLTSQECVDLVHYGISQGN
.. |..||  |.|. |. .| . ||.  . . .
aaqflvlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_PPM1H_pd Subfamily PPM1H 96-170 7.6e-11 34.4 In-house 140-210 (404) alignment 
Range on Protein: 96-170
Range on HMM: 140-210/404.0
LIDTFLATDVELLKDEKLKDDHSGCTATVILVsqLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTllSEKSRI
| . ||  |  . ....   .. |||| | ||  |.. |  ||.|||| .|.. ......|.|. |   .|. |.
lesaflemDeqiarereayrikGGCtalvalv..llgklYvanaGDsRailvrkdeiiplsadftPe..teRqRl
subfamily_PHLPP_pd Subfamily PHLPP 54-250 2.3e-10 32.8 In-house 26-213 (246) alignment 
Range on Protein: 54-250
Range on HMM: 26-213/246.0
HLAFYGIFDGHGGSSVAEFCGSKMISILKKQESfKSGMLEQCLIDTFLATDVELLK-DEKLkddhsGCTATVILVSQ-----LK-KLLICANSGDSRTVL
. | ||.|||.  . ...     | ..|| . . |.   |. .  |.|..  .| .  |||     | .| .||. .     .|   |  |. |   .||
vealyGlfdGdrneelssllqrlmkdvlkeevq.kdkneeeymkntllvaqrklGeaGekl.....gsaallilirhdkvdPaksfsLevAsvGtlqavl

STGGNskAMSFDHKPTLLSE-KSRIVAADGFVEM-DRVNGNLALSRAIGDFEFksntklGPheqVVTCVPDIICHNLNyDEDEFVILACDGIWDCLTSQE
  .|.   . . .. .. ..  .||  | ....  ...|| .. .| .| .         |   ||   | .    |. ..||..|.  . .|. |  .|
iRngk..klrlsksyviekdelkrikeakaiitednkingviestrllGytfl......fP...vvlPkphvrevlLt.eqdellivGnkalWevlside

CVDLVH
 |. |.
aveavr
Subfamily Dicty-PPM1L-like 84-194 3.2e-10 32.3 In-house 181-294 (305) alignment 
Range on Protein: 84-194
Range on HMM: 181-294/305.0
QESFKSGMLEQCLIDTFLATDVELLKDEKLKDDHsGcTATVILVSQLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADG-----FVE
..  .. .|. .|....   .  |||  . | |  . .  ..   . ..||  |...|.. ||.| |  ...|.....  . |. |.   ..     | |
eiririeslqaalynygellvnrllkksrskGdk.n.lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne

MDRVNGNLALSRAIGD
. || ...|..| .||
isrviveeavkrgsgD
subfamily_PPM1H_pd Subfamily PPM1H 180-251 1.1e-08 27.3 In-house 275-349 (404) alignment 
Range on Protein: 180-251
Range on HMM: 275-349/404.0
DRVNGNLALSRAIGDFEFKSNTKLGPHEQVVTCVPDIICHNLN---YDEDEFVILACDGIWDCLTSQECVDLVHY
 |. . .. .| .|| | |   .      ....||..   .|.    .||. .||| ||.|| |. .|   .|. 
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivre
PP2C_SIG_SM00331 51-291 1.4e-08 27.5 In-house 26-215 (217) alignment 
Range on Protein: 51-291
Range on HMM: 26-215/217.0
DEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKsgmleqcliDTFLATDV--------EllkdekLKDDHSGCTATVILVSQLKKLLICANSGDS
..|.  .. ..||.|.   |. . |.. . |... | .         ...  .          |       .......|....|.   .. |  || |||
lnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaGds

RTVLSTggnSKAMS----FdhkptllseksrivaadgfvemdrvngnlalsraigdfefKSNTKLGPHEQVVtcvpdIICHNLNYDEDEFVILACDGIWD
| .| .   .. .     .                                        ..   || ...|      .  ..|.........|. ||...
rpyllr...dgklveilkd........................................vegaplGlepevs.....vdirelelekgdllllytDGlte

CLTSQE--CVDLVHYGIS-QgNMTLSDISSRIVDVCCSPTTEGSGigCDNMSISIV
  ....    .| .   . . .... .....||.  .. ...  |   |.... .|
arsekgfaeerleeiledlv.dseaqelaqkiveellelakgsng..eDdiTvvvv
subfamily_PP2D1_pd Subfamily PP2D1 23-84 3.8e-08 25.5 In-house 2-62 (492) alignment 
Range on Protein: 23-84
Range on HMM: 2-62/492.0
AFGLCAMQ--GWRMSMEDAHIVEPNLLAESDEehlAFYGIFDGHGGSSVAEFCGSKMISILKKQ
|.|.|  .   |. .|||.. .  . . . ..   .|.||.||. |.. || . ...  .| ..
avGiCedknsrWKskmeDkrtlqdyfgndvns...cFfgiyDGynGataAeiaakelhevllee
Subfamily Dicty-PPM1L-like 181-269 6.3e-07 21.5 In-house 200-285 (305) alignment 
Range on Protein: 181-269
Range on HMM: 200-285/305.0
RVNGNLALSRAIGDFEFKSNTKlgpheqvvtCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNM------TLSDISSRIVD
.||. |  || .|| . |               .|   ....  .|.|..|| ||.|. |  |. |. |.  . .  .         .||..|| 
lvnrllkksrskGdknlkelvi.........PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrvive
Subfamily Dicty-PPM1L-like 23-82 1.2e-06 20.6 In-house 8-64 (305) alignment 
Range on Protein: 23-82
Range on HMM: 8-64/305.0
AFGLCAMQGWRMSMEDAHIVEPNLLaesDEEHLAFYGIFDGHGGSSVAEFCGSKMISILK
 ..| . .. |   || . |   |.   ....| ..|.||||.|   ||.   |.. |. 
kyelyvsansrkyqedrnkvkisle...ssqelslfGvfdGhnGdiaaeyvkkklveivn
PPM_PTC7_SpoIIE_motif 221-290 1.6e-06 21.7 In-house 7-77 (81) alignment 
Range on Protein: 221-290
Range on HMM: 7-77/81.0
LNYDEDEFVILACDGIW-------DCLTSQECVDLVHYGiSQGNmtLSDISSRIVDVCCSpttEGSGIGCDNMSISI
. . ... ..|..||..       .... .| ..|..   ....  | ... ..|| . .    |||   |.... .
fqLkpgdvllLyTDGltEardsdgelfgkeellrladra.egks..lqeladklvdevle...ngsgereDDitllv