Gene PTC1 in Saccharomyces cerevisiae

Synonym: CWH47, KCS2, TPD1, YDL006W, PTC1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP009_AA protein Get Run
ScerP009_AA_14-281 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 16-281 8.3e-91 297.2 In-house 9-280 (282) alignment 
Range on Protein: 16-281
Range on HMM: 9-280/282.0
DITYRVGVAENKNskFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQ-------NILADETRDVRDVLNDSFLAIDEEINTKL
....|.||.....  .|..||| ||.|...... ||..||||||||| ...|.. |||.. | .       .. |.|...|...|...|||.||.|... 
gnglrygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels

VGNS-----GCTAAVCVLRwelpdsvsddsmdlaqhQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGD
  ..     |.|| .....                 ...|..||.||||.||.|||....||.|||.|.. |..|.||||| ...|||||.|||.|.|||
tdlktadksGsTavtvlvs.................ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGD

KFFDS---------LVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDI----TEPNEAAKVLVRYALENGTTDNVTVMVVFL
.....         ||...| .||.|...||.||.|||||.|||..|....||...     .|..| || ||..|||.|..||..|.||..
yeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
PPM_PTC7 23-274 2.4e-81 266.0 In-house 3-259 (259) alignment 
Range on Protein: 23-274
Range on HMM: 3-259/259.0
VAENKNSKFRRTMEDVHTYVKNFA---SRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLA--IDEEINT---K-LVGNSG
.  .....||..|||.|.. .|..   .. ....|||||||.| .|.|....||..|.....  .|.... ..|..||||  .|||...   . .  .||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

CTAAVCVLRWELpdsvsddsmdlaqhqrkLYTANVGDSRIVLFRNGNSI-RLTYDHKASDTLEMQRVEQAGGLIM---KSRVNGMLAVTRSLGDKFFDS-
.|| |.... .                  ||.|||||||.||.|.||.. .||.|||.|.. |..|.|.||| ..   ..||||.|||.|..||..... 
stAvvalitgsk.................lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpk

-----LVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITE---PNEAAKVLVRYALENGTTDNV
     ||. .| ..|..|..||.|||||.||||||..||.|..|...  .   |.|||. ||..|...|..||.
eteeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 23-274 4.7e-81 265.1 Pfam-A 3-255 (255) alignment 
Range on Protein: 23-274
Range on HMM: 3-255/255.0
VAENKNSKFRRTMEDVHTYVKNFA---SRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLA-IDEEINT---K-LVGNSGC
|  ......|..||| |.. ||.    .. ....|||||||.| .|.|....||..|.....  .| ..|...|..|||| .|||...   . .  .||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAAVCVLRWELpdsvsddsmdlaqhqrkLYTANVGDSRIVLFRNGNSI-RLTYDHKASDTLEMQRVEQAGGLIM-KSRVNGMLAVTRSLGDKFFDS----
|| |...| .                  ||.|||||||.||.|..|.. .||.|||.||. |..|.|.||| .. . ||||.|||.|.|||... .    
tavvalirgkk.................lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeq

LVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITE----PNEAAKVLVRYALENGTTDNV
||. .| .|||..|.||.|||||.||||||..||.|..|...  .    |.|||. ||..|...|..||.
lvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 23-274 4.7e-81 265.1 In-house 3-255 (255) alignment 
Range on Protein: 23-274
Range on HMM: 3-255/255.0
VAENKNSKFRRTMEDVHTYVKNFA---SRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLA-IDEEINT---K-LVGNSGC
|  ......|..||| |.. ||.    .. ....|||||||.| .|.|....||..|.....  .| ..|...|..|||| .|||...   . .  .||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAAVCVLRWELpdsvsddsmdlaqhqrkLYTANVGDSRIVLFRNGNSI-RLTYDHKASDTLEMQRVEQAGGLIM-KSRVNGMLAVTRSLGDKFFDS----
|| |...| .                  ||.|||||||.||.|..|.. .||.|||.||. |..|.|.||| .. . ||||.|||.|.|||... .    
tavvalirgkk.................lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeq

LVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITE----PNEAAKVLVRYALENGTTDNV
||. .| .|||..|.||.|||||.||||||..||.|..|...  .    |.|||. ||..|...|..||.
lvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
0034914 PP2C-like 15-281 6.2e-75 244.6 In-house 17-290 (295) alignment 
Range on Protein: 15-281
Range on HMM: 17-290/295.0
YDITYRVGVAENKNSkfRRTMEDVHTYVKNFAS-RLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQN------ILADETRDVRDVLNDSFLAIDEEINTK
.   .||||| ...   |...|| ...| |. |   |...|.||||| | .|.... ..|.... ..      .| ... |....| ..|||.|||. ..
lllllrvgvasdqGr..rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

LVGN-----SGCTAAVCVLRWElpdsvsddsmdlaqhqrKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLG
.. .     ||.|| |...| .                 |||.|||||||.||.|||  ..||.||| .. ||..|...||| .. .||||.|||||.||
allrpelagsGtTavvalirgn.................klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalG

DKFFD---------SLVVGSPFTTSVEIT-SEDKFLILACDGLWDVIDDQDACELIKD----ITEPNEAAKVLVRYALENGTTDNVTVMVVFL
| ..           ||.  | .|..|.| ..|.||.||.||||||............     ....|||. ||..||..| .||.||.||.|
dfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
PP2Cc_SM00332 17-279 4.8e-74 242.2 In-house 8-274 (274) alignment 
Range on Protein: 17-279
Range on HMM: 8-274/274.0
ITYRVGVaeNKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADET---RDVRDVLNDSFLAIDEEINTKLVG---
  .. |.  ... . |..|||.|  | .. .. ||..|.|||||.| ...|.. |.|. ......  ...    || ..|...||..||||...      
lglsygk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

---NSGCTAAVCVLRWELpdsvsddsmdlaqhqrkLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFD
   .||.|| |..|. |                  || |||||||.||.|||....|..|||..|  |..|...||| ..| ||||.|||.|..||.|. 
enalsGstavvallkked.................lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflk

-------SLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDIT------EPNEAAKVLVRYALEN-GTTDNVTVMVV
         ..  | .. |..||||.|||||.||||||...|.........       .| |||. |...|... | .||.||.||
knkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 29-279 3.3e-61 199.8 In-house 14-251 (255) alignment 
Range on Protein: 29-279
Range on HMM: 14-251/255.0
SKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETrDVRDVLNDSFLAIDEEIntklvgnsgctaavcvlrWELPDS
   | ||||  .   .|  . |  |.|.||||.| .|.|.. ..|. |... . . .. .  ..|.... .|.  |                   | |  
iGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqi..................serpkf

VSDDSMDLAQHQRKLYTANVGDSRIVLF-RNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKS----RVNGMLAVTRSLGDKFFDSLVVGSPFTT-SVEIT
.   .. .   . | | |||||||.||  ..| . ||..||| |.  | .|....|| ....    ||||.|||.|.||| |..  ||  |  . |.||.
iGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleis

SEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVV
 .||||||||||.||.| |..|.|.. .|..|..||. |  .| ..|.|||..|.|.
kkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivi
0049733 PP2C-like 30-281 4.6e-60 195.7 In-house 13-233 (235) alignment 
Range on Protein: 30-281
Range on HMM: 13-233/235.0
KFRRTMEDVHTYvknfasrlDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGN-----SGCTAAVCVLRWE
..|...|| . .        ....|||.||| | .|.... ..|.... . .|. .. |....| ..|||..|..  . . .     .|.||.|..|. .
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalldgg

LpdsvsddsmdlaqhqrkLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLImksRVNGMLAVTRSLGDKFFDslvvgsPFTTSVEITSE
                  ||.|||||||..|.|.|. ..||.||. .. ||.||...||| .   ||.|.||.||.||| ...      | .|..|....
k.................lyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk......pdvtvlelepg

DkFLILACDGLWDVIDDQDACELIKDiTEPNEAAKVLVRYALENGTTDNVTVMVVFL
| ||.||.||||||..|.....|... ....|||. ||..||..|..||.||.||.|
d.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 25-281 3.1e-56 183.5 In-house 10-262 (265) alignment 
Range on Protein: 25-281
Range on HMM: 10-262/265.0
ENKNSkfRRTMEDVHTYVKNFASRLD------WGYFAVFDGHAGIQASKWCGKHLHTIIEQNilADETRDVRDVLNDSFLAIDEEINTK---LVGNSGCT
  ||   ||.||| |  .... . ..        .|||||||.|..|.|.  .|||. . ..   . ..|  . |...| ..||.. .|      .||.|
avknk..rrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrq..eklkedpaealkeafkltDerflqkaereklksGst

AAVCVLRwelpdsvsDDSmdlaqhqrkLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMK---SRVNGMLAVTRSLGDKFFDSLVVG
| |....         |          || | .|||. .| |.|. ..|.  || ..  | .|.|.||||...    ||||.|.|.|..||.     |.|
avvvlie........kdq.........lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsg

SPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPN-----EAAKVLVRYALENGTTDNVTVMVVFL
 . ...||.......|||||||||||........|...  . .     |.||.||  | |.| .||.||.||||
eadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1K_pd Subfamily PPM1K 50-280 2.6e-47 154.1 In-house 30-257 (263) alignment 
Range on Protein: 50-280
Range on HMM: 30-257/263.0
DWGYFAVFDGHAGIQASKWCGKHLHTIIEQNIlaDETRDVRDVLNDSFLAIDEEINTKLVGNSGCTaavcvlrwELPDSVSDDSMDLAQHQRKLYTANVG
.  |.||||||||  | ... ..|..|...    .. .|.. ||...|. .|....  |  .   .        ||  | .  .. | ..  .|  |..|
ellyvavfdGhaGsaaadfvhdklekilkrll..ekekdleivlknafeeldkklkrylefsvaea........ellssGttatvsllrdGtelvlaslG

DSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIM-----KSRVNGMLAVTRSLGDKFF-DSLVVGSPFTTSVEI-TSEDKFLILACDGLWDVIDDQ
||| .| |||.. .|| ||. .   | .|. .||| .      | .|||.||.||||||  .  . |.  | | |...  ..| ||.|  ||. .|...|
dsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsq

DACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVF
. |.|..  ..|.|||..|.  ||. |. ||.|..|| 
elcdlvrlchdpeeaahalteqalqygsednatavvvp
subfamily_PPM1G2_pd Subfamily PPM1G2 28-281 6.4e-47 152.9 In-house 26-286 (287) alignment 
Range on Protein: 28-281
Range on HMM: 26-286/287.0
NSKFRRTMEDVHTYVKNFAS---RLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADeTRDVRDVLNDSFLAIDEEINTK-LV--GNSGCTAAVCVL
   .|..||| |.  ... .     .  .||||||| | ...|..||.|. .|...   .    .. .|.|.||..|||.  .  .   ..|.|| | ..
mqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.egaleqilkdafletDeellkdeklkdesaGstavvvli

RwelpdsvsddsmdlaqhQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFD---------SLVVG
.                 ..||| ||.|||| ||  .||.  |..||| ... | .|...|||..   |||| ||. |.|||  |           .|  
k.................eeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivta

SPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKD----ITEPNEAAKVLVRYALENGTT------DNVTVMVVFL
 |  .  .....| ||.|||||.|||. ... ..|..      ....| .. |.  .| . .       ||.||..| |
vPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PPM_PTC7_SpoIIE 24-273 2.5e-43 141.5 In-house 4-229 (230) alignment 
Range on Protein: 24-273
Range on HMM: 4-229/230.0
AENKNSKFRRTMEDVHTYVKNFA---SRLDWGYFAVFDGHAGIQasKWCGKHLHTIIEQNIlADETRDVRDVLNDSFLAIDEEINTKlVGNSGCTAAVCV
  ......|..|||.|.. .|..    .  . .....||| | .  ... ..|.|... ..   ..... ..|....||.. ..... ...||.|| |..
gasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede.psssgaTavval

lrwelpdsvsddsmdLAQHQRKLYTANVGDSRIVLFRNgNSIrltydhkasdtlEMQRVeQAGGLIM----KSRVNGMLAVTRSLGDKFFDS---LVVGS
               .  ...|||.||.|||...|.|. .              |  |. .||||..      ||.| |||... ||...     .|  .
...............idpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveae

PFtTSVEIT-SEDKFLILACDGLWDVIDDQDACELIKDITEPNeAAKVLVRYALENGTTDN
|  || ... ..|.|||||.|||||| ..|....|..|  |.. ||. |.....  .....
pd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv
subfamily_KAPP-like_pd Subfamily KAPP-like 49-280 1.7e-40 131.7 In-house 32-265 (266) alignment 
Range on Protein: 49-280
Range on HMM: 32-265/266.0
LDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILA-------DETRDVRDVLNDSFLAIDEEINTklVGNSGCTAAVCVLrWELPdsvsddsmdlaqHQR
 . . |||||||||  |..   | .  ..|. .         |.  | ...|...|  .|....       |.||..... |.              .||
snialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkd..feyeGatatlalv.wsdG............qqr

KLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIM--KSRVNGmLAVTRSLGDKFFDSLVVG---SPFT-TSVEITSEDKFLILACDGL
 | .||||||   | |  .|. |..|||| |  | ||. . |  .   ..|.|| |||.|.|||.|   | .|    |.    . .|  |||||.| |||
ylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGl

WDVIDDQDACELIKDITE----PNEAAKVLVRYALENG-TTDNVTVMVVF
||||. .|| | .| . .     .. |. |.. |..   . |||.|.|| 
wdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_ILKAP_pd Subfamily ILKAP 32-259 1.9e-40 131.8 In-house 16-270 (293) alignment 
Range on Protein: 32-259
Range on HMM: 16-270/293.0
RRTMEDVHTYVKNFASR--------LDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADET----RDVRDVLNDSFLAIDEEINT-----KLVGNSGC
| .|.|.|. .... ..            |.|||||||| .||... ..||  | ...  ...    ....  | ||| . |||  .     | |   |.
reemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGs

TAAVCVlrwelpdsVSDDSmdlaqhqrkLYTANVGDSRIVLFRNGN------SIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDS
||.|..        | |.          ||.||.|||. || |. .      |..|| ||.. .  | .|...||| . ..||.|.| |.||.||  | .
tatvvl........vldnv.........lyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr

L-VVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAA--------------------K
| |.  |... .|.|  |.|..|||||||.|.. ... . | .. | .|                      .
lGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacn
subfamily_PPM1L_pd Subfamily PPM1L 32-280 1.9e-40 131.8 In-house 16-265 (269) alignment 
Range on Protein: 32-280
Range on HMM: 16-265/269.0
RRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNIL---ADETRDV----RDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLrwe
|  |||  .. .. . . .  .||||||| |  |.... . |   | ....   ||  . .      .|.|  |..||.. .|.  .   . . ...   
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttali...

lpdsvsddsmDLAQhQRKLYTANVGDSRIVLF-RNGNSIRLTYDHKASDTLEMQRVEQAGGLIMK---SRVNGMLAVTRSLGDKFFD--SLVVGSPFTTS
           | | ...|  ||||||| ||. ..|..| |..|||  .  | .|...|||.|      ||.|.||..|.|||  .    ||. .|   .
..........alvq.esdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdilt

VEITS-EDKFLILACDGLWDVIDDQDACELIKD-ITEPNEAAKVLVRYALENGTTDNVTVMVVF
 ..   . .|||||.||||| . ...|.. ||. . ||.  || ||  .   |..||.||.|| 
fdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 49-280 4.8e-39 126.9 In-house 31-275 (276) alignment 
Range on Protein: 49-280
Range on HMM: 31-275/276.0
LDWGYFAVFDGHAGIQAS----KWCGKHLHTIIEQ--------NILADETRDVRDVLNDSFLAIDEEINTklVGNSGCTAAVCVLrWelpdsvSDDSMDL
 . . |||||||||  |.    |   | |  ...         .   |.  | ...|.| |  .|....       |.||..... |      ||   . 
snialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkd..feyeGatatlalv.w......sdGeeqq

AQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIM--KSRVNGmLAVTRSLGDKFFDSLVVG---SPFT-TSVEITSEDKFLIL
 |.|| | .||||||   | |  .|. |..||||.|  |.||. . |  .   ..|.|| |||.|.|||.|   | .|    |.    . .|  |||||.
qqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkfliv

ACDGLWDVIDDQDACELIKDITE----PNEAAKVLVRYALENG-TTDNVTVMVVF
| |||||||. .|| | .| . .     .. |. |.. |..   . |||.|.|| 
asdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PPM1D_pd Subfamily PPM1D 26-281 1.5e-29 96.1 In-house 7-307 (309) alignment 
Range on Protein: 26-281
Range on HMM: 7-307/309.0
NKNSKFRRTMEDVHTYVKNF---ASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQ--NILADETRDVRDVLNDSFLAIDEEINTKLVGNSGcTAavcv
. ..  |. |||| . | .    | .|.. ..|||||| | .|.|.  .|| . |..  ..|..| .||.. ....|||. |... ||   .  |.    
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpk.tk....

lRWELPDSVSDDSMDLAqHQRKLYTANVGDSRIVLFRNGN------SIRLTYDHKASDTLEMQRVEQAGGLIMKS----RV---------NGM-------
 . .|  . .  |. .   ..|||.|.||||.|||  . .      .  || ||| ..  | .|.|..|| ....    ||         ||        
.sgllstaGttasvvii.rreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiP

-LAVTRSLGD-----KFFDSLVV-GSPFTTSVEITSE-DKFLILACDGLWDVIDDQDACELIKDITEPNEA--------AKVLVRYALENGTT-----DN
 |||.|||||     .. .. ||  .| .. .... . .||.||| ||||.|.  .|| .....  | .|         ||.||. ||..  .     ||
FLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDn

VTVMVVFL
|.|.||.|
vsvivvil
subfamily_PPM1G_pd Subfamily PPM1G 139-256 1.7e-29 96.1 In-house 306-433 (473) alignment 
Range on Protein: 139-256
Range on HMM: 306-433/473.0
HQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIM-KSRVNGMLAVTRSLGDKFF---------DSLVVGSPFTTSVEITSEDKFL
...||. ||.|||| || |||. . | .|||  |  |..|.|.||| .    |||| | . | ||| ..         . ..   |     ..|.||.||
kekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFl

ILACDGLWDVIDDQDACELIKDITEPNE
.|||||.|.|.. |.  . ...  . .|
vlAcDGiWnvmesqevvdfvraklkkge
subfamily_PP2D1_pd Subfamily PP2D1 88-251 2e-28 92.3 In-house 113-305 (492) alignment 
Range on Protein: 88-251
Range on HMM: 113-305/492.0
DVRDVLNDSFLAIDEEINT-----KLVGNSGCTAAVCVLR-----------WELPDSV---SDDSM--DL-AQHQRKLYTANVGDSRIVLFRNGNSIRLT
.|.  .. |.| .|. ...      .|  ||| |  ..|.           .|  ||     ..|   ..  . .  || ||.|. . || |.|..|.||
kvkkAfrksylrldrlLsygieeesrvrWsGCsAltllleGnkreteatekeekkdseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLt

YDHKASDTLEMQRVEQAGGLIMKS----RVNGMLAVTRSLG---DKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDI
 .|   .. | .|||.||. ..||    .|||.| .|| ||   |    . |.  | ||||... ...||.||  |||.|.....  .|.|..
reHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqt
subfamily_PHLPP_pd Subfamily PHLPP 18-280 2.1e-26 85.3 In-house 4-244 (246) alignment 
Range on Protein: 18-280
Range on HMM: 4-244/246.0
TYRVGVAENKNSKFRRTMEDVhtyvknfasrLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADEtrDVRDVLNDSFLAIDEEINTKlVGNSGCTAA
....|..| .  | .  .. .           .   . .|||..  . |.   . .. ... ..  |.  .... ..  .|..  .. ..     | .| 
vfsiGlsesaGvknklcvaal..........svealyGlfdGdrneelssllqrlmkdvlkeevqkdk..neeeymkntllvaqrklGea.Geklgsaal

VCVLRwelPDSVSDDSMdlaqhqRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTlEMQRVEQAGGLIMK-SRVNGMLAVTRSLGDKFFDSLVVGSPFT
.. .|   .| |   .        .|  |.||    || |||. .||.  .. ..  |..|. .| ..|   ...||... || ||  |    |. .|  
lilir...hdkvdPaks......fsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPkphv

TSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVF
 .| .|..| .||.  . ||.|.. ..| | ...  .|  ||| ||  |   |..|.|.|.|| 
revlLteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvr
PPM_PTC7_motif 229-274 2.5e-18 59.3 In-house 1-51 (51) alignment 
Range on Protein: 229-274
Range on HMM: 1-51/51.0
ILACDGLWDVIDDQDACELIKDITE-----PNEAAKVLVRYALENGTTDNV
|||.||||||..||.|..|..|  .     |.|||. ||..||..|..||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_SIG_SM00331 53-280 5.3e-15 48.6 In-house 32-216 (217) alignment 
Range on Protein: 53-280
Range on HMM: 32-216/217.0
YFAVFDGHA-GIQASKWCGkHLHTIIEQNILADetRDVRDVLNDSFLAIDEEintKLVGNSGCTAAVCVLrwelpdsvsddsmdlAQHQRKLYTANVGDS
 ..|.||.  |..|.   .  |.| ... . ..   .. ..|.    ||.||   | ......|. ....                  ..||. ||.|||
llvvaDgmGkGlaAaaass.qlrtalrellseg..eelsqalkrlnraiyee...keekgmfaTlllaly...............dfssgklsyanaGds

RIVLFRNGNSIRLTYDhkasdtlemqrveqaggliMKS---------RvngmlavtrslgdkffdslvvgsPFTTSVEITSeDKFLILACDGLWDV----
|..|.|.|. .  . |                    ..         .                       . ....|.   . .|.|. |||...    
rpyllrdgklveilkd...................vegaplGlepevs.......................vdirelelek.gdllllytDGltearsek

-IDDQDACELIKDIT--EPNEAAK----VLVRYALENGTTDNVTVMVVF
 ..... .|...| .  |. | |.     |...| .... |..||.||.
gfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PP2D1_pd Subfamily PP2D1 21-92 9.5e-15 47.2 In-house 3-79 (492) alignment 
Range on Protein: 21-92
Range on HMM: 3-79/492.0
VGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILA-DE----TRDVRDV
||. |.|||... .||| .| . .|.   . ..|...||. |  | . . |.||... ...   ||    | .|. .
vGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnli
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-195 1.9e-14 46.9 In-house 24-174 (292) alignment 
Range on Protein: 54-195
Range on HMM: 24-174/292.0
FAVFDGHA--GIQASKWCGKHLHTIIEQniLADETRDVRDVLNDSFLAIDEEINTKL--VGNSGCTAAVCVLrwelpdsVSDDsmdlaqhqRKLYTANVG
 ||.|||   | . ..   ..|   . .  |  . ... . |    | |  ...      ..|. ||.||         | ||        |.|. ||||
aavldGhGvnGdkvaqlaedtlevelle..ltrqlqelsealllrildiaakldkltidaresattavvcar.......vrdd........ralilanvG

DSRIVLFR-----NGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNG-----------------ML
||| .|.|     . . | |. ||| .|  | .|. .||| .  .|| |                  |
dsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdl
subfamily_PPM1G_pd Subfamily PPM1G 31-107 2.6e-14 46.1 In-house 29-102 (473) alignment 
Range on Protein: 31-107
Range on HMM: 29-102/473.0
FRRTMEDVHTYVKNFASrlDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADEtRDVRDVLNDSFLAIDEEINTK
.|  .||.|. . .. .  |.  |||.||| | . .|.. |.|  .. ..   .|  ||.  |...|||.||.....
wrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgyke.gdvekaleeaflalDeklkae
Subfamily Dicty-PPM1L-like 178-281 9.2e-13 40.7 In-house 185-303 (305) alignment 
Range on Protein: 178-281
Range on HMM: 185-303/305.0
RVEQAGGLIMK---SRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEIT-SEDKFLILACDGLWDVIDDQDACELIKDITE-----------PNEAAKVLV
|.| ... ...    .||..| . || |||    ||.  .      .. ..|.||.|| ||||.|.. ||  | .|.. .           .||  .| |
rieslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviv

RYALENGTTDNVTVMVVFL
  |.. |  ||.|.....|
eeavkrgsgDnitlviikl
PPM_PTC7_SpoIIE_motif 224-279 8.7e-11 35.4 In-house 11-78 (81) alignment 
Range on Protein: 224-279
Range on HMM: 11-78/81.0
EDKFLILACDGLW-------DVIDDQDACELIKDItE---PNEAAKVLVRYALENG---TTDNVTVMVV
..  |.|..|||.       ..........|...  |   . |.|. ||. .||||   ..|..|..|.
pgdvllLyTDGltEardsdgelfgkeellrladra.egkslqeladklvdevlengsgereDDitllvl
subfamily_PDP_pd Subfamily PDP 212-258 2e-10 33.3 In-house 272-318 (398) alignment 
Range on Protein: 212-258
Range on HMM: 272-318/398.0
GSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAA
 .|  || .....||||.|| |||||....... .|... .. ....
aePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
subfamily_PDP_pd Subfamily PDP 79-204 6.4e-10 31.7 In-house 105-238 (398) alignment 
Range on Protein: 79-204
Range on HMM: 105-238/398.0
QNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCvlrwELPDSVSDDSMDLA-QHQRKLYTANVGDSRIVLFRNG-----NSIRLTYDHKASD
|..|  |...|...|. .|| .|..| |. . ..  .        .|  ..|     ||  ....|. ||.||.| || ..      ....|. |. |. 
qelleaevekvkealkkaFlklDkdistealkklkekslre....allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadn

TLEMQRVEQA------GGLIMKSRVNGMLAVTRSLGDK
. |..|....        .|...|. | |. .|  || 
eeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdv
subfamily_TAB1_pd Subfamily TAB1 140-204 4.1e-08 25.4 In-house 140-210 (333) alignment 
Range on Protein: 140-204
Range on HMM: 140-210/333.0
QRKLYTANVGDSRIVLFR---NGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVN---GMLAVTRSLGDK
  ||| ||||||| .| .   . .   |  ||.     |..|... |  | . . |   |    |||.|| 
nnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdy
subfamily_PPTC7_pd Subfamily PPTC7 136-256 8.9e-08 24.8 In-house 96-198 (252) alignment 
Range on Protein: 136-256
Range on HMM: 96-198/252.0
LAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGlimksrvngmlavtrSLGDKFFDSLVVGSpfTTSVEITSEDkFLILACDGL
| ....||..||.||| .. .|.|. .  .   . .     |   .. |                 |.   |.   ..  ..|... ..|  ..|| |||
ldksdkklesanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapeg...............regkvildkpeaad..sksfavkkgD.iivlatDGl

WDVIDDQDACELIKDITEPNE
.| . ...  | .|...| ..
fDNlledeileilkelkesek
subfamily_PPM1H_pd Subfamily PPM1H 37-81 1.3e-07 23.8 In-house 48-92 (404) alignment 
Range on Protein: 37-81
Range on HMM: 48-92/404.0
DVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNI
. ..  |.....|.  ||..||||||  |.  . | ||.......
tskpkekseeeklplayfglfDGhaGsgaalvaskllhkhlkekl
subfamily_PPM1H_pd Subfamily PPM1H 188-255 3e-07 22.5 In-house 274-354 (404) alignment 
Range on Protein: 188-255
Range on HMM: 274-354/404.0
KSRVNGMLAVTRSLGDK---FFDSLVVGSPFTTSV-EI---------TSEDKFLILACDGLWDVIDDQDACELIKDITEPN
|.|. . ..||| |||      |. .   || ..| |.         ..||. |||| ||||||...... |..... . .
kaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 217-271 1.2e-06 21.3 In-house 239-291 (292) alignment 
Range on Protein: 217-271
Range on HMM: 239-291/292.0
TSVEITSEDKFLILACDGLWDVIDDQDACELIKDitEPNEAAKVLVRYALENGTT
 . |. |.|.||.|| ||. ||. ...   |..    .. |.||.   ||| |..
lekeldsddaflvlasdGvldvllnaevvlllak..sqeaadkvitelaleygls
subfamily_PPM1H_pd Subfamily PPM1H 140-170 7.3e-06 18.0 In-house 173-203 (404) alignment 
Range on Protein: 140-170
Range on HMM: 173-203/404.0
QRKLYTANVGDSRIVLFRNGNSIRLTYDHKA
. ||| || |||| .| |....| |  |.  
lgklYvanaGDsRailvrkdeiiplsadftP