Gene SIT4 in Saccharomyces cerevisiae

Synonym: PPH1, YDL047W, SIT4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP012_AA protein Get Run
ScerP012_AA_5-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP6C_pd Subfamily PPP6C 7-294 1.5e-166 545.7 In-house 3-288 (290) alignment 
Range on Protein: 7-294
Range on HMM: 3-288/290.0
DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYPA
|.|.|..|||..|.||..|.||..|..||.||||.|||..||||||||||||.||.|||||.| .||. .|.||||.||||||||||||.|..||.|||.
dkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdt.syvflgdfvdrgyysletftrlltlkakypd

KITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAW
.|||.||||||||||||||||.|||||||....||||..|||.||.|||||...|||||||||....||||||..||||.||.|.|.||.||||..||.|
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKdVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDY
.|||||||.||||||..||.|.| |.||.||||||.||.||.| || .||||||||||||||||||....... | ..|.|.||||..
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdek.lvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
subfamily_PPP4C_pd Subfamily PPP4C 7-292 9.9e-150 490.5 In-house 4-287 (288) alignment 
Range on Protein: 7-292
Range on HMM: 4-287/288.0
DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPdDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPA
|. .|....|. ..|.|.|.||. ..|.|.||||.| |..||||||||||||.||||||. .|  | . ||.||||.||||.||.||| ||..|||.||.
drqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvp.etnylflgdfvdrgfysvetfllllalkvrypd

KITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAW
.|||.||||||||||||||||.|||.||||..||.||..|||.|.|||||||||.||||||||.|. ||.||.. | ||||||| ..|||||||...|.|
ritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegw

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEkDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPD
 |||||||.||||.|. .||. |...||.|||||||||.|.|| |  |.||||||||||||||||.....||.|.  ||||.|.. 
avsprgagylfgsdvveqfneandielicrahqlvmegyklhfne.kvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP2C_pd Subfamily PPP2C 7-291 3.5e-141 462.5 In-house 5-287 (290) alignment 
Range on Protein: 7-291
Range on HMM: 5-287/290.0
DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPdDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPA
|...| .|.|. |.|.|.|.|||..||.|..|||.|.|..|||||||.|||||||||||.  |  | | ||.||||||||||||.|| |||..|||.|. 
dklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggksp.dtnylflgdyvdrgyysvetvtllvalkvryke

KITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAW
.||..||||||||||||||||.||| |||...||||  ..||.|.|.|..|..|.|.||||||.|  ||.|| | | ||||||| ..||||||||. . |
ritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrggw

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVP
..||||||. || .....||. |||.||||||||||||... . ...|||..||||||||||| |.....|..|. .|  | . |
gisprgagytfgkdisekfnktngltliarahqlvmegynwsh.drnvvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPG1_pd Subfamily PPG1 7-293 5.4e-123 403.0 In-house 2-299 (300) alignment 
Range on Protein: 7-293
Range on HMM: 2-299/300.0
DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDdINYIFLGDYVDRGYYSLETFTLLMCLKVKYPA
|| || ..|.. | |  .|.|.. .||||..|||.. ...|||| ||.||||.|.||.|.  |  ||  ||.|||||||||.||.|| .||..||..||.
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpd.tnylflgdyvdrglysvetisllivlklryps

KITLVRGNHESRQITQVYGFYEECLNKY-GSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPD----
.|||.|||||||||||||||| |||.|| | ..||||  ..||.|.|||||| .| ||||||||... .|||.|| | .|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------NVE--AWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKdVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDD
      . |   ..||.||||. .| .|. .| . | .| | |||||..||.. .| .| . |||||||||||||| ||.... | .|  |..... |..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnk.lstvwsapnycyrcgnkasilelyekderyfnvyeeapes
PPP_3 19-288 6.6e-116 379.0 In-house 2-270 (271) alignment 
Range on Protein: 19-288
Range on HMM: 2-270/271.0
LTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFrTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESR
|.|||.|.|....||.|..|||.. ...|||||||||||..|||||| . ||.... .|.|||||||||..|||...||..||.||| ...|.|||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelf.knggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

QITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDL-LWSDPDNVEAWQVSPRGAGWLF
||..||||..|.|.|.|...|.|....||..|.|||.||.|.|.|||||||.|..||||. |.| .|||.|| . || |.|||.. | .. |.||||.||
qinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllF

GSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPeKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
|..|..||.. | |.||.|||.|..||.....  . ||||.||||||.|..|.....|..|.|...||...
gpdvteefleknkLkliiRaHelkeeGyeilhd.gkvvtvfSapnycerasnagailkleealtsefkqle
0045823 Metallo-dependent phosphatases 6-299 2.4e-115 378.8 In-house 30-333 (473) alignment 
Range on Protein: 6-299
Range on HMM: 30-333/473.0
PDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYP
.|...|..||.. |.|.....|....||.|..|.|..... ...|.||||||..|||.|.. .|  |.| ...||||.||||..|||.. ||..||.|||
ldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfpped.rlvflGDlvDrGpdslevlelllalkikyp

AKITLVRGNHESRQITQVYGFYEECLNKYGSTtVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEA
 ...|.|||||.|.....|||..|.| |||   .......... | |||.|.||||.|||||||... ||||| . | .|.|..| . |||||||.... 
gnvfllrGNHElrllnglygfgdetlekyged.lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKD-----VVTVWSAPNYCYRCGNVASVMKVDEDLePTFKIFSAVPD
        .. ||||||.||| ....|| . |||.|| |.|. |.||....|  |      ..||.||||||.|.|| |.|...|||| ..|..| ..|.
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph

DYIREST
..|.. .
plilplf
PPP_1 20-276 1.3e-109 358.5 In-house 2-264 (264) alignment 
Range on Protein: 20-276
Range on HMM: 2-264/264.0
TENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRtAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQ
.|.|...|....||||..|.|.. |....||||||||||.|||.||. .||.... ||.|||||||||..|.|...||..||.||| ...|.||||||||
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfk.vggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrq

ITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDL--------LWSDPDNVEAWQVSPR
.|.||||..|.|.|..|....|....|||.|.|||.||.|||.||||||||...||||| ..| .|||.|| ..||        |..|... ||.. |.|
vtkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiR

GAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKV
|||.|||..|...|.. |.|.||.|||....||..... .. |||..||.||.....| ....|.
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflk.krkvvtifsasnyyeegsnrgayvkl
0049330 Metallo-dependent phosphatases 6-294 3.1e-108 354.4 In-house 17-303 (309) alignment 
Range on Protein: 6-294
Range on HMM: 17-303/309.0
PDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDdINYIFLGDYVDRGYYSLETFTLLMCLKVKYP
 |...|...|.. |.|.|...|....||.|..|.|..... ...|.||||||..|||.|.. .|  |.  ...||||.||||..|||...||..||..||
ldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevlllllalkllyp

AKITLVRGNHESRQITQVYGFYEECLNKYGsTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPD-NVE
 ...|.|||||.|.....|||..|.| |||   .|........ | |||.|.||||||||||||.. .||||| | | .|.|..| . |||||||.  .|
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

AWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDY
 .. .|||.|..||  . ..| ..|||.|| |.|..|..|....| .....||.||||||.|.||...|...||||...|..| .||  .
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltff.dgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
0053225 Metallo-dependent phosphatases 7-291 1.7e-103 339.0 In-house 10-292 (293) alignment 
Range on Protein: 7-291
Range on HMM: 10-292/293.0
DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDdINYIFLGDYVDRGYYSLETFTLLMCLKVKYPA
| ..|...... |.|.|...|....||.|..|.|..... ...|.|||||...|||.|.. .|  |.  ...||||.||||..|||...||..||..|| 
dllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllalkllypd

KITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAW
...|.|||||.......|||..|.| |||.  .|........ | |||.|.||||.|||||||..  ||||| . | ...|.|| . |||||||| .. |
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPeKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVP
  |.||.|..||  . ..| . |||.|| |.||.|..|....|  ...|||.|||||..|.||...|...||.| ..||.| .|.
lpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfd.gklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
PP2Ac_SM00156 20-288 2.4e-102 334.6 In-house 2-268 (271) alignment 
Range on Protein: 20-288
Range on HMM: 2-268/271.0
TENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGgFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQ
...|...|.| |||.|..|.|.  |..||||.||||||..|||.|...|| .|.. .|.|||||||||..|.|. .||..||..|| |..| ||||||..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

ITQVYGFYEECLNKYgSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDP-DNVEAWQVSPRGAGWLFG
....|||.||. .|| .. ... . ..|. |.|||..| ||||.|||||||.. ||.|| | |..| |.|| . ||||||| .... .| | ||.. .||
vnkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFg

SKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
.....|| . | |.|| |||..|.||... . .| .||..||||||....|.|.|.||...|..... . 
edavkeflkknnlkliiRahevvdeGyeffa.dkklvtifsapnycdefsnkaavlkveknlklsieqlk
subfamily_PPP1C_pd Subfamily PPP1C 14-288 2.2e-101 331.7 In-house 5-277 (282) alignment 
Range on Protein: 14-288
Range on HMM: 5-277/282.0
KKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTaGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRG
.|   |.|.|...|... .|.|.... .  .. ||...||||||..||| || | .|.|.. ||.|||||||||  |||| .||...|.||| .. |.||
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfet.sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrG

NHESRQITQVYGFYEECLNKYGSTtVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRG
|||| .|...||||.|| ..|... .||   .||..| |||..| ||||||||||||.. |.||| ..|  |||..|   ||||||||. |. |. . ||
nhesasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

AGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
  . ||..| ..| . | |.|| ||||.| .|... | .. .|||.|||||| . .| ..|..|||.|  .|.|. 
vsftfgkdvvekflqkndldlivrahqvvedGyef.fakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 13-288 3.8e-96 314.6 In-house 18-292 (298) alignment 
Range on Protein: 13-288
Range on HMM: 18-292/298.0
IKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTaGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVR
 | .....|.....|.|..|... . . .  |..|..||||||||. ||| ||   .||| | ||.||||||||| ..||. .||.. ||||| .. |.|
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk.agfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllr

GNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPR
||||  .| .|||||||| ..| |.....   .||. | |.|.| |.|||.|||||.... |||.| |.|... ..|    ||||.||.| |. |. . |
GnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensr

GAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
|..  ||..| ... .   ..|..||||.| .|... | || .||..|||.|| .  | |.||||||.|. .|... 
GvsvvfGedvvkdllekldidlvvrahqvvqdGyef.faekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-290 5.8e-91 297.8 In-house 22-294 (299) alignment 
Range on Protein: 17-290
Range on HMM: 22-294/299.0
QALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAgGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHE
... |.|...||.. |. ..... .  |..|. ||||||||. ||| .|  | ||| |.|..|||||||||   ||. |||.| |.||| .. ..|||||
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka.gfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRGAGW
   | .|||||||| ..| || .|    . |... |. .| ..|||.||||||... |||.| |.| |. |      ||||.|||. |  |.   ||  .
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

LFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAV
.|| .| ..  .  ...|.|||||.| .|... | .| .||..||| || .  | |..|||||.|  ||...   
vfgqdvvadvisrldidlvarahqvvqdgyef.faskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 15-288 4.1e-84 275.4 In-house 3-281 (284) alignment 
Range on Protein: 15-288
Range on HMM: 3-281/284.0
KCQAL-TENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAgGFP------DDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAK
.|| | .|.|. .||   .||. .|.  . ...||...||||||| ||| |.    |.|      .. .|.||||||||| .|.|  |||...|...| |
ncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldln.gwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdk

ITLVRGNHESRQITQVYGFYEECLNKYgSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPD-NVEAW
..|.||||||| . . ||||.|| ..| |.....     |  . |.|... ||.|.|||.| ..  |.|.  |.|  ..|  |  .|| |.||. .|| .
vfllrgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegy

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
. |||||| .||.|  .||..   |.|. ||||.||.|... | .. .||..||| || .  |.|.|..|||.|. .|... 
kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyef.fadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 15-287 1.2e-82 270.2 In-house 4-272 (280) alignment 
Range on Protein: 15-287
Range on HMM: 4-272/280.0
KCqaLTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAgGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGN
.|  . | ..... | .|..|. .. .  |..||.||||.|||. ||| ||  . .|| | ||.||||||||| . ||   ||.. ||.|| .. ..|||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv.sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYEECLNKYgSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPD-NVEAWQVSPRGA
||  .| . |||..|. ..| |  ...   ...| | |.|.. |.|||.|||||.... ||... | |  . ..|    ||||.||. .|  |  ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIF
  .||..| ... .   ..|||| ||.| .|... | .| .|||.|||.|.    | |.|..||| |. .|...
svifganvvkdltekldidliarghqvvqdgyef.fadkklvtvfsapkylgefdnsaavlivderlivsfevl
subfamily_PPP3C_pd Subfamily PPP3C 15-280 1.9e-80 263.8 In-house 37-313 (452) alignment 
Range on Protein: 15-280
Range on HMM: 37-313/452.0
KCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTaGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGN
|   |.|... .. |.. .|| .|...  |..|.||.|||||||.|||.||   || |....|.||||||||||.|.|.   |..||..|| .. |.|||
kegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfev.gGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGn

HESRQITQVYGFYEECLNKYGsTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN----V---EA-W
||.| .|. . | |||  ||.  .|.. |.. || | |||..... |||||||||||. ||.|. | | .|.|. | . ||||||| .        |.  
hecrhlteyftfkeeckikys.eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfv

QVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFP-----EKDVVTVWSAPNYCYRCGNVASVMKVDEDL
. |.||  .... | . || . | |  | |||.   .|.. .          ..|..|||||.    | |.|.|.... 
pnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
PPP_2 48-240 5e-79 257.6 In-house 1-197 (198) alignment 
Range on Protein: 48-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFHDLLELFrTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVF
||||||.|||..|||.|| . |..... .|.|||||||||..|||...||..||..|| ...|.||||||.....||||..|.|.|.|...|.|....||
vtvcGDlHGqldDLlilf.knglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

DFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDL-----LWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQL
..|.|||.||.|.|.||||||.||..||||.  .| .|.|.|| . ||     |...... | .. | ||||.|||..|..|. . | |.|| |||..
elLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPZ_pd Subfamily PPZ 15-288 1.6e-77 254.0 In-house 21-292 (300) alignment 
Range on Protein: 15-288
Range on HMM: 21-292/300.0
KCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFrTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGN
|  .| ..|. |.|   .||.. . ..  .  .| . ||.|||. ||| || |  |||   ||.|||||||||  ||||  ||.| |.||| .. |.|||
knvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlf.tkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgn

HESRQITQVYGFYEECLNKyGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDP-DNVEAWQVSPRGA
||  ..|.|||||.||  .     .||   . |. | ||||. |||.|||||||| .  .|.|| ..|  .||  |   ||||||| |. . |.   || 
hecanvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergv

GWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFS
 . .      .|    |..|..||| .| .|... | .. .|||.||||||    |  .|| | | |  .|... 
sycynkvainkflnkfgfdlvcrahmvvedgyef.fndrslvtvfsapnycgefdnwgavmsvsegllcsfelld
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 18-287 2.9e-77 252.6 In-house 6-274 (281) alignment 
Range on Protein: 18-287
Range on HMM: 6-274/281.0
A-LTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHE
  .|..|....  .|. ...||...  ...|..| ||.|.||.|| .||   |  |..  ..|||||||||  |||.. ||..||..|. .| |.|||||
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpee.vlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYEECLNKYGStTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRGAGW
  .. ..||||.||  |||   .|    . |. | ..| |. ..||.|||||||.  ||..|   .  . .. |   ||||.|||| || |. | ||...
iasvnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIF
.|| .|  .     ...|| ||||.|..|..  .  . ..||.|.||||    | |.|.||||.|. ... .
tfGknvvddvckrleveliirahqvvqdGyev.lsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_PPP5C_pd Subfamily PPP5C 9-295 4.4e-76 248.9 In-house 24-314 (322) alignment 
Range on Protein: 9-295
Range on HMM: 24-314/322.0
WLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQT----PVTVCGDIHGQFHDLLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKY
 ||..|| ..| .  . ..  ..|||| ... .  ...     .||||||||||.|||..|.  |   ..  |.| ||.|||| .|.|.  .|...|. |
llelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfklly

PAKITLVRGNHESRQITQVYGFYEECLNKYGStTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSP-EIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNV
| .. | |||||| .. ..||| .|. .|| . .| .   .||..| || .|. |.| |||||   .   ||..| ..| .. |.|| . .||||||.. 
PnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea

EAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKV-DEDLEPTFKIFSAVPDDYI
.  . | || |  ||  |...| . |.|.|| |.|.. .||.. .  .  ..||.|||||| . || ...... ..||...|| | ||.   .
nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyeveh.dGklitvfsapnycdqmgnkgafitlrgddlklkfktfeavehpdv
PPP_4 48-240 3.1e-75 245.5 In-house 1-196 (197) alignment 
Range on Protein: 48-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFHDL-LELFRtAGGFPD-DINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKyGSTTVWKYCCQ
|||.||||||..|| |.|..  ||.|. . .|.|||||||||..|||...||..||..||....|.||||||......|||..|.|.|  . ...|....
vtvvGDiHGqlddlllkllk.ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqd

VFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVP-HEGGFSDL-LWSDPD-NVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQL
|||.|.|||.||.|.|.||||||.|.. ||.|. ..|..|.| .|. . || |||||  . | .. | ||||.|||..|...| . |.|.|| |.|.|
vfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 48-240 6e-74 241.3 In-house 1-198 (199) alignment 
Range on Protein: 48-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFHDL-LELFRtAGGFPD-DINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQ
||||||.|||..|| |.||.  ||.|. . .|.|||||||||..|||...||..||..||....|.|||||..|....|||..|.|.||..  ..|....
vtvcGDlHGqlddlllilfk.eggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

VFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVP-HEGGFSDL-LWSDPD-NVEA-WQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQL
|||.|.|||.||.|.|.|||||||||. ..... . |..|.| ..|  .|| |||||  ..|  .. | ||||.||| .|...| . |.|.|| |.|.|
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 16-285 1.1e-73 240.6 In-house 7-277 (287) alignment 
Range on Protein: 16-285
Range on HMM: 7-277/287.0
CQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAgGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNH
 .|...... .. | ..|.|   . .  |..|.|..||||||..||| .|    | . ...|.|||||||||  |||   ||..||..|| |. |.||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnav.GaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnh

ESRQITQVYGFYEECLNKYGsTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQE--VPHEGGFSDLLWSDPDN-VEAWQVS-PR
| ..| ..|||.||  .|..   ..|   .||. |.| |... .|||.|||.||... ||... |.. .     .||   ||||.||..  .. ..   |
evkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkir

GAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFK
.   .|| |.  .. .  ...|| |||... ||... | .| .|||.||| |. .  |...|..|.. || .| 
aisvvfGkkevddllkkldidlivrahevseeGyaflf.dkrlvtvfsapyysgedtnlgavvvvskslelsfv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 15-287 4.4e-72 235.9 In-house 19-292 (297) alignment 
Range on Protein: 15-287
Range on HMM: 19-292/297.0
KCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRtAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGN
 .. .||. . .| ..  ...  . ..  |..|. ||||||||| ||| ||.  ||.|   ||.||||||||| .|.||  ||.. |||.|... |.|||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfh.rggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSP---EIRMLDQIRVLSRAQEVpHEGGFSDLLWSDPD-NVEAWQVSP
||   . .|||||||| ..| |  ..    .||..| |. .|  ||||.||||||   .   || .| . |..|  .|.  .||||.||   .  .    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIF
||||  ||     .      |.|..||||.| .|... |  . .||..||| || .  |.|..| .|| |. .|.|.
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyef.fagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 76-288 1.5e-71 234.2 In-house 102-313 (317) alignment 
Range on Protein: 76-288
Range on HMM: 102-313/317.0
NYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYgSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLD
.|.||||||||| .|.|  .||..||..|| |..|.||||||| . . ||||.|. ..| |.....   ..|  | |.|... ||||.|||.| |.  |.
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVM
|. .| |  ..|  |  .|| |.|||. |. .. |.|||| .||.|  .||..   |.|. ||||.|..|... | .. .||..|||.|| .  |.|.|.
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyef.fadrklvtifsapsycGqldniaavl

KVDEDLEPTFKIFS
.||..|. ..... 
svdkklkisinvlr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 11-285 4.3e-68 222.4 In-house 8-284 (290) alignment 
Range on Protein: 11-285
Range on HMM: 8-284/290.0
ETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRtAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITL
.     .|...... .. | ..|.|     .  |..|... ||||||. .||. |  | |.| .....|||||||||  |||   ||.|.|..|. |. |
lkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfd.avgyppkvkflflgdyvdrgakslevslllfcykiryskkvhl

VRGNHESRQITQVYGFYEECLNKYGStTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRA--QEVPHEGGFSDLLWSDPDN--VEAW
.||||| |.. ..|||.||   | ||  .||   .||. |.| | .. ||||.|||.|..|   . .. | .   .   .||   ||||.||..   .. 
lrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddti

QVS-PRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFK
..   |.   .|| |.  .. .  .|.|| |||..  |||.. | .| .|||.||| |. .  |. ....| | || .. 
alnkqraisvvfgkkglddllkklalslivrahevkeegfnflf.dkklvtvfsapyysgndtnlgaiatvseslelsiv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 16-286 4e-67 219.6 In-house 3-271 (280) alignment 
Range on Protein: 16-286
Range on HMM: 3-271/280.0
CQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNH
|. .|  |.  .  ||. ..|||||.   ..|. | |||| |..|.  ||   |  |.. . .|||||||||   .| . ||.|||..|  .| |.||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpee.klmflgdyvdrgpqgievlillfclkiryrdriyllrgnh

ESRQITQVYGFYEECLNKYGSTTVWKYCcQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRGAG
|.  . ..|||| ||  |||    | .   .|. . ....|  ..||.|||||||.  || || . |  |    | . ||||||| |  |.|  | ||  
etpsvnkiygfyvecqykygvglwwdfq.scfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgis

WLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKI
..||  |  .  .   ..|| ||||.| .|..  .  . ..||.| |||| .  | |.|. .. .|. .|. 
ymfgkgvveqacksleidliirahqvvqdgyem.magrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 41-286 1.1e-66 218.1 In-house 25-270 (284) alignment 
Range on Protein: 41-286
Range on HMM: 25-270/284.0
IQPVQTPVTVCGDIHGQFHDLLELFRTAgGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVW
.  |..|. .|||||||| ||| ||    |||   ||.||||||||| . |||  ||.. || .| .. ..|||||   | ..|||||||  .|   .|.
lievnspinicgdihgqfsdllrlfdkn.gfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvy

KYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFS-DLLWSDPDNVE-AWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAH
.    ||  . |.|..  .|||.|||.|  .. . |.| . |  . |    .. |.||||| |..  |.   ||  ..|||   |..     ..|. |||
vsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrah

QLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKI
|.| .|... | .. .||..||| || .  | |.|| |...|  .| .
qvvqdgyef.fanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 19-291 1.3e-61 201.5 In-house 20-291 (307) alignment 
Range on Protein: 19-291
Range on HMM: 20-291/307.0
LTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGfPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESR
 | .|....    . ..  |  .  .. |. | ||.|||| ||...|   |  | .  |.| |||||||  |||.  ||.. |. || .| |.|||||  
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgr.ppetvyvftgdyvdrgllslecilllftykicypenivllrgnheia

QITQVYGFYEECLNKYG--STTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDN-VEAWQVSPRGAGW
.. . |||||||.         .|    ..|. | ..|.|  ||||.|||||| .  ||..|   .    |  |   |.||.|||  |  |. | ||.|.
rvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgf

LFGSKVAREFNHVNGLNLIARAHQLVMEGFkYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEptFKIFSAVP
 ||..|  .  .  |..|| ||||....|. . .  . ..|..||| ||    |   |.|||| |    .. . ||
tfgtnviddvckrlgveliirahqmcfdgy.wvlsgrklitifsapmycnfyknagcvlkvdetlg..iqlvafvp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 17-279 4.1e-58 189.9 In-house 4-289 (302) alignment 
Range on Protein: 17-279
Range on HMM: 4-289/302.0
QALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTA-----------GGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYP
. ....|. .|.|.| ||| .|...  . .|||. |||||||.||. .. .             .|  |  ..|||||||||. |.|  .|...||| ||
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssd.kfvflGdyvdrGsksieciclvfalkvlyp

AKITLVRGNHESRQITQVYGFYEECLNKYGSTT---VWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRA-QEVPHEGGFSDLLWSDPD
 .  |.|||||.. |   ||| ||  |..| .    .|.   .|| |. |||..  ||||||||.|| .. |..|. ..|  .|| ..    |||..|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

NVEAWQVS----------PRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDED
.|.. ..            ||   .|     |.. .  .|.|| |||| . ||||. | .| ..|..|||.|     |  .|.||| .
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkf.fadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 17-279 6e-58 189.4 In-house 5-290 (302) alignment 
Range on Protein: 17-279
Range on HMM: 5-290/302.0
QALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTA-----------GGFPDDiNYIFLGDYVDRGYYSLETFTLLMCLKVKYP
. ....|. .|.|.| ||| .|...  . .|||. |||||||.||. .. .             .|  |  ..|||||||||. |.|  .|...||| ||
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssd.kfvflGdyvdrGsksieciclvfalkvlyp

AKITLVRGNHESRQITQVYGFYEECLNKYGSTT---VWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRA-QEVPHEGGFSDLLWSDPD
 .  |.|||||.. |   ||| ||  |..| .    .|.   .|| |. |||..  ||||||||.|| .. |..|. ..|  .|| ..    |||..|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

NVEAWQVS----------PRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDED
.|.. ..            ||   .|     |.. .  .|.|| |||| . ||||. | .| ..|..|||.|     |  .|.||| .
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkf.fadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-288 3.7e-53 173.8 In-house 121-332 (339) alignment 
Range on Protein: 76-288
Range on HMM: 121-332/339.0
NYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGStTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLD
 |.||||||||| .|.|   || .||. || .| |.||||||| .   |||| |   .| .  ...   ..|. . ..|.|.  |.|.|||.|  .  ..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRVLSRAQEVPHEGGFSDLLWSDPDNVE-AWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVM
|. |. |  |.|  | ..|| |.|||  |  .. | ||| ..||    | | .   |... | ||.| .|... |  . .||..|||||| .  | |.|.
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyef.fdgrrlvtifsapnycgqndntaavf

KVDEDLEPTFKIFS
 .|. |. . ..| 
sidkklkisinvfr
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 44-285 5.6e-52 170.0 In-house 5-251 (263) alignment 
Range on Protein: 44-285
Range on HMM: 5-251/263.0
VQTPVTVCGDIHGQFHDLLELFRTAGgFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGST----TV
.|.|. .||| |||. ||| .| ..|      .|.||||||||| .|||   ||. ||.  | |. |.||||| . | . |||. |  ...       .|
lqapinicgdthgqyndllrifnacg.aatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesv

WKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGG-FSDLLWSDPDNvEAWQVSP---RGAGWLFGSKVAREFNHVNGLNLIA
...  ||| .. |.||.  .|||.|||.|| .. ||.|| .    |  .      ||||.||.. .|  . |   |    .|| |   .. .   ..|| 
ynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLVMEGFKYhFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFK
||||.|  |. . | .. ..||.||  |     | |.|. |.. || .| 
rahqvveygyaf.fadrrlitvfsasryqielcnyaavvvvnkmlelsfv
subfamily_PPPLV_pd Subfamily PPPLV 25-277 4.8e-48 156.9 In-house 3-276 (290) alignment 
Range on Protein: 25-277
Range on HMM: 3-276/290.0
KQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLE----LFRTaGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQI
  ||..  . |..| .. ....|. | ||.||...||      |.|| |      ...||||||||| .|.|  . |. ||| ||.|. |.||||| . .
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrt.gvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

TQVYGFYEECLNKYGST--TVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLS----RAQeVPHEGG--FSDLLWSDPDNVE-----AWQ
.. . .. |.  |.| .   ||.   .|||.| |||.|| |..|||.|.   |    .|  .     | .  . .|     |.|||||.. .     . .
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk.ddidgaplaldilwsdpaedrdlslrgel

V--------SPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCgNVASVMKVD
|        . || | .|...    | ..|.|. . |||.   .|...   .  ..||.|. .||    | |... ||
vlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqq.kgrlltvfsssrycGss.neaalilvd
Metallophos Calcineurin-like phosphoesterase 47-240 3.2e-45 147.9 Pfam-A 2-198 (200) alignment 
Range on Protein: 47-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFHDL---LELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLL--MCLKVKYPAKITLVRGNHESRQITQVYGFYEECL----------
...|.||.||...||   |...  ... ..  ...||||.|||| .|.||. ||   .||...| .. |.||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------NKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIrvlsraqevpheggfsdllwsdpdnveawqv
                       .... . .. .....|..| |.|..|||||..||.||..    |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGSKVAREFNHVNGLNLIARAHQL
    ...|||... ...   .|. |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 9-182 2.5e-37 121.5 In-house 23-201 (383) alignment 
Range on Protein: 9-182
Range on HMM: 23-201/383.0
WLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTP----VTVCGDIHGQFHDLLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKY
 .|..|. . |  . . ..    |. | .  ||. |.|     ||||||.||.. ||| ..   |    . .|.| ||.||||  |.|   .|..| . |
lieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvy

PAKITLVRGNHESRQITQVYGFYEECLNKY--GSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPeIRMLDQIRVLSR
| .. | |||||   .   |||  |  .||   .. . .   .|| .| ||..|| ||| ||||.|  .  |. .  ..|
pkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisd.ktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 194-287 1.1e-14 47.0 In-house 239-332 (383) alignment 
Range on Protein: 194-287
Range on HMM: 239-332/383.0
DLLWSDPDNVEA-WQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFpEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIF
|.||||| . |  .  . ||.|  ||. |.... .  .|.|. |.|.  .||...   .| |.|..|| ||     |  . .|. .||.| .  .
dilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvh.dkkvltifsasnyyeeGsnrGayvklgkdltprivqy
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 14-72 7.7e-13 41.3 In-house 3-61 (317) alignment 
Range on Protein: 14-72
Range on HMM: 3-61/317.0
KKCQA-LTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAgGFP
||||  ..|.|. .||   .||. .|     ...|||..|||||||.||| |.    |.|
kkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldln.Gwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 19-68 3.3e-08 26.0 In-house 11-60 (339) alignment 
Range on Protein: 19-68
Range on HMM: 11-60/339.0
LTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTA
.   |. .||   .||.  |  .  ...|. | ||||||| ||| ..   
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
subfamily_YNL217W_pd Subfamily YNL217W 48-120 4.5e-08 25.9 In-house 12-79 (235) alignment 
Range on Protein: 48-120
Range on HMM: 12-79/235.0
VTVCGDIHGQFHDLLELFR-TAGGFPDDINYIFLGDYVDRGYYSLETFTLLmclkvkYPAKITLVRGNHESRQI
. | ||.|| . .|.||.   .||  ...  ...|| ...|  |.|.  ..         .   |.||||   .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvl